Aliases for TNFRSF4 Gene
- Tumor Necrosis Factor Receptor Superfamily Member 4 2 3 5
- TAX Transcriptionally-Activated Glycoprotein 1 Receptor 3 4
- Tumor Necrosis Factor Receptor Superfamily, Member 4 2 3
- OX40L Receptor 3 4
- ACT35 Antigen 3 4
- CD134 Antigen 3 4
- TXGP1L 3 4
- Tax-Transcriptionally Activated Glycoprotein 1 Receptor 3
- Lymphoid Activation Antigene ACT35 3
External Ids for TNFRSF4 Gene
Previous HGNC Symbols for TNFRSF4 Gene
Previous GeneCards Identifiers for TNFRSF4 Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF4 Gene
TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily Member 4) is a Protein Coding gene. Diseases associated with TNFRSF4 include Immunodeficiency 16 and Combined Immunodeficiency Due To Ox40 Deficiency. Among its related pathways are TNF Signaling (sino) and ERK Signaling. GO annotations related to this gene include tumor necrosis factor-activated receptor activity.
UniProtKB/Swiss-Prot for TNFRSF4 Gene
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.