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Aliases for TNFRSF4 Gene

Aliases for TNFRSF4 Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 4 2 3
  • TAX Transcriptionally-Activated Glycoprotein 1 Receptor 3 4
  • OX40L Receptor 3 4
  • ACT35 Antigen 3 4
  • CD134 Antigen 3 4
  • TXGP1L 3 4
  • Tax-Transcriptionally Activated Glycoprotein 1 Receptor 3
  • Lymphoid Activation Antigene ACT35 3
  • OX40 Cell Surface Antigen 3
  • OX40 Homologue 3
  • ATC35 Antigen 3
  • OX40 Antigen 3
  • ACT35 3
  • CD134 3
  • IMD16 3
  • OX40 3

External Ids for TNFRSF4 Gene

Previous HGNC Symbols for TNFRSF4 Gene

  • TXGP1L

Previous GeneCards Identifiers for TNFRSF4 Gene

  • GC01M000673
  • GC01M000898
  • GC01M001023
  • GC01M001052
  • GC01M001186
  • GC01M001136
  • GC01M000418

Summaries for TNFRSF4 Gene

Entrez Gene Summary for TNFRSF4 Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF4 Gene

TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4) is a Protein Coding gene. Diseases associated with TNFRSF4 include immunodeficiency 16 and combined immunodeficiency due to ox40 deficiency. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include tumor necrosis factor-activated receptor activity.

UniProtKB/Swiss-Prot for TNFRSF4 Gene

  • Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.

  • (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.

Gene Wiki entry for TNFRSF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF4 Gene

Genomics for TNFRSF4 Gene

Regulatory Elements for TNFRSF4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNFRSF4 Gene

1,211,326 bp from pter
1,214,638 bp from pter
3,313 bases
Minus strand

Genomic View for TNFRSF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF4 Gene

Proteins for TNFRSF4 Gene

  • Protein details for TNFRSF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 4
    Protein Accession:
    Secondary Accessions:
    • Q13663
    • Q2M312
    • Q5T7M0

    Protein attributes for TNFRSF4 Gene

    277 amino acids
    Molecular mass:
    29341 Da
    Quaternary structure:
    • Interacts with TRAF2, TRAF3 and TRAF5. (Microbial infection) Interacts with Human herpesvirus 6B/HHV-6B gQ1:gQ2 proteins (PubMed:23674671).
    • Sequence=AAB33944.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNFRSF4 Gene

neXtProt entry for TNFRSF4 Gene

Proteomics data for TNFRSF4 Gene at MOPED

Post-translational modifications for TNFRSF4 Gene

  • Glycosylation at Asn 146 and Asn 160

Other Protein References for TNFRSF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFRSF4 (OX40/TNFRSF4)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF4 (TNFRSF4)

No data available for DME Specific Peptides for TNFRSF4 Gene

Domains & Families for TNFRSF4 Gene

Gene Families for TNFRSF4 Gene

Protein Domains for TNFRSF4 Gene

Suggested Antigen Peptide Sequences for TNFRSF4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 TNFR-Cys repeats.
  • Contains 4 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF4: view

Function for TNFRSF4 Gene

Molecular function for TNFRSF4 Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 4,tax-transcriptionally activated glycoprotein 1 receptor
UniProtKB/Swiss-Prot Function:
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.

Gene Ontology (GO) - Molecular Function for TNFRSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005031 tumor necrosis factor-activated receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TNFRSF4: view
genes like me logo Genes that share phenotypes with TNFRSF4: view

Animal Models for TNFRSF4 Gene

MGI Knock Outs for TNFRSF4:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for TNFRSF4 Gene

Localization for TNFRSF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TNFRSF4 Gene COMPARTMENTS Subcellular localization image for TNFRSF4 gene
Compartment Confidence
plasma membrane 4
cytosol 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TNFRSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7510240
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface ISS --
genes like me logo Genes that share ontologies with TNFRSF4: view

Pathways & Interactions for TNFRSF4 Gene

genes like me logo Genes that share pathways with TNFRSF4: view

Pathways by source for TNFRSF4 Gene

PCR Array Products

SIGNOR curated interactions for TNFRSF4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TNFRSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA --
GO:0006955 immune response TAS 7510240
GO:0006968 cellular defense response IEA --
GO:0007275 multicellular organismal development IBA --
GO:0030890 positive regulation of B cell proliferation ISS --
genes like me logo Genes that share ontologies with TNFRSF4: view

Drugs & Compounds for TNFRSF4 Gene

(2) Drugs for TNFRSF4 Gene - From: IUPHAR, DGIdb, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
OX-40 ligand Pharma 0
Cyclosporin A Pharma Inhibition, Inhibitor Immunosuppressive agent, Calcineurin inhibitor 0

(1) Additional Compounds for TNFRSF4 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF4: view

Transcripts for TNFRSF4 Gene

mRNA/cDNA for TNFRSF4 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFRSF4 Gene

Tumor necrosis factor receptor superfamily, member 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF4 Gene

No ASD Table

Relevant External Links for TNFRSF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF4 Gene

mRNA expression in normal human tissues for TNFRSF4 Gene

mRNA differential expression in normal tissues according to GTEx for TNFRSF4 Gene

This gene is overexpressed in Spleen (x6.3) and Whole Blood (x5.4).

SOURCE GeneReport for Unigene cluster for TNFRSF4 Gene Hs.129780

genes like me logo Genes that share expression patterns with TNFRSF4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TNFRSF4 Gene

Orthologs for TNFRSF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNFRSF4 35
  • 74.4 (n)
  • 63.41 (a)
  • 62 (a)
(Canis familiaris)
Mammalia TNFRSF4 35
  • 72.01 (n)
  • 64.18 (a)
  • 63 (a)
(Mus musculus)
Mammalia Tnfrsf4 35
  • 71.68 (n)
  • 65.04 (a)
Tnfrsf4 16
Tnfrsf4 36
  • 62 (a)
(Pan troglodytes)
Mammalia TNFRSF4 35
  • 87.96 (n)
  • 83.58 (a)
(Rattus norvegicus)
Mammalia Tnfrsf4 35
  • 68.97 (n)
  • 61.38 (a)
(Monodelphis domestica)
Mammalia TNFRSF4 36
  • 50 (a)
(Gallus gallus)
Aves TNFRSF4 35
  • 44.9 (n)
  • 37.14 (a)
  • 30 (a)
(Anolis carolinensis)
Reptilia TNFRSF4 36
  • 27 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfrsf4 35
  • 45.21 (n)
  • 33.75 (a)
Species with no ortholog for TNFRSF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFRSF4 Gene

Gene Tree for TNFRSF4 (if available)
Gene Tree for TNFRSF4 (if available)

Paralogs for TNFRSF4 Gene

No data available for Paralogs for TNFRSF4 Gene

Variants for TNFRSF4 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs17568 -- 1,212,042(-) CAGGA(A/G)ACCCA synonymous-codon, reference
rs1055324 -- 1,211,443(-) CAACT(C/T)TGCAC utr-variant-3-prime
rs1055326 -- 1,211,433(-) CCGTT(C/T)TAGGT utr-variant-3-prime
rs2298208 -- 1,211,019(+) GACCC(C/T)GCTAC downstream-variant-500B
rs2298209 -- 1,211,405(+) AAGCA(C/G)AGAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF4 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
nsv517709 CNV Gain+Loss 19592680
nsv428334 CNV Gain 18775914
dgv2n67 CNV Gain 20364138
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
dgv11n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
nsv871553 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv469848 CNV Gain 16826518
dgv21n71 CNV Loss 21882294
nsv871744 CNV Gain 21882294
nsv482937 CNV Loss 15286789
dgv22n71 CNV Loss 21882294
nsv871107 CNV Loss 21882294
dgv23n71 CNV Loss 21882294
nsv871427 CNV Loss 21882294
nsv871680 CNV Loss 21882294
dgv24n71 CNV Loss 21882294
nsv871329 CNV Gain 21882294
dgv25n71 CNV Loss 21882294
dgv26n71 CNV Loss 21882294
nsv871512 CNV Loss 21882294
dgv27n71 CNV Loss 21882294

Variation tolerance for TNFRSF4 Gene

Residual Variation Intolerance Score: 84.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF4 Gene

Disorders for TNFRSF4 Gene

MalaCards: The human disease database

(11) MalaCards diseases for TNFRSF4 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 16
  • ox40 deficiency
combined immunodeficiency due to ox40 deficiency
  • combined immunodeficiency with childhood onset kaposi sarcoma
classic kaposi sarcoma
  • hhv8
childhood oligodendroglioma
  • pediatric oligodendroglioma
graft-versus-host disease, protection against
  • graft versus host disease
- elite association


  • Immunodeficiency 16 (IMD16) [MIM:615593]: An autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency. {ECO:0000269 PubMed:23897980}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TNFRSF4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TNFRSF4: view

No data available for Genatlas for TNFRSF4 Gene

Publications for TNFRSF4 Gene

  1. The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen. (PMID: 7510240) Latza U. … Stein H. (Eur. J. Immunol. 1994) 2 23 67
  2. TNF activates a NF-kappaB-regulated cellular program in human CD45RA- regulatory T cells that modulates their suppressive function. (PMID: 20181891) Nagar M. … Goldstein I. (J. Immunol. 2010) 23 67
  3. OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology. (PMID: 20510730) Ishii N. … Sugamura K. (Adv. Immunol. 2010) 23 67
  4. Decreased 4-1BB expression on HIV-specific CD4+ T cells is associated with sustained viral replication and reduced IL-2 production. (PMID: 19406689) Kassu A. … Palmer B.E. (Clin. Immunol. 2009) 23 67
  5. The role of OX40-mediated co-stimulation in T-cell activation and survival. (PMID: 19538134) Redmond W.L. … Weinberg A.D. (Crit. Rev. Immunol. 2009) 23 67

Products for TNFRSF4 Gene

Sources for TNFRSF4 Gene

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