Aliases for TNFRSF4 Gene
- Tumor Necrosis Factor Receptor Superfamily Member 4 2 3 5
- TAX Transcriptionally-Activated Glycoprotein 1 Receptor 3 4
- Tumor Necrosis Factor Receptor Superfamily, Member 4 2 3
- OX40L Receptor 3 4
- ACT35 Antigen 3 4
- CD134 Antigen 3 4
- TXGP1L 3 4
- Tax-Transcriptionally Activated Glycoprotein 1 Receptor 3
- Lymphoid Activation Antigene ACT35 3
External Ids for TNFRSF4 Gene
Previous HGNC Symbols for TNFRSF4 Gene
Previous GeneCards Identifiers for TNFRSF4 Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF4 Gene
TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily Member 4) is a Protein Coding gene. Diseases associated with TNFRSF4 include immunodeficiency 16 and combined immunodeficiency due to ox40 deficiency. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include tumor necrosis factor-activated receptor activity.
UniProtKB/Swiss-Prot for TNFRSF4 Gene
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.