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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF4 Gene

protein-coding   GIFtS: 63
GCID: GC01M001136

Tumor Necrosis Factor Receptor Superfamily, Member 4


(Previous symbol: TXGP1L)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 41 2     CD1342
TXGP1L1 2 3 5     ATC35 Antigen2
ACT35 Antigen2 3     Lymphoid Activation Antigene ACT352
CD134 Antigen2 3     OX40 Antigen2
OX40L Receptor2 3     OX40 Cell Surface Antigen2
TAX Transcriptionally-Activated Glycoprotein 1 Receptor2 3     OX40 Homologue2
ACT352 5     Tax-Transcriptionally Activated Glycoprotein 1 Receptor2
OX402 5     Tumor Necrosis Factor Receptor Superfamily Member 42

External Ids:    HGNC: 119181   Entrez Gene: 72932   Ensembl: ENSG000001868277   OMIM: 6003155   UniProtKB: P434893   

Export aliases for TNFRSF4 gene to outside databases

Previous GC identifers: GC01M000673 GC01M000898 GC01M001023 GC01M001052 GC01M001186 GC01M000418


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF4 Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to
activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice
suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus
suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as
well as in T cell-dependent B cell proliferation and differentiation. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFRSF4 Gene: 
TNFRSF4 (tumor necrosis factor receptor superfamily, member 4) is a protein-coding gene. Diseases associated with TNFRSF4 include graft versus host disease, and chronic graft versus host disease, and among its related super-pathways are TNF Signaling and STAT3 Pathway. GO annotations related to this gene include tumor necrosis factor-activated receptor activity.

UniProtKB/Swiss-Prot: TNR4_HUMAN, P43489
Function: Receptor for TNFSF4/OX40L/GP34

Gene Wiki entry for TNFRSF4 (CD134) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004350.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF4 gene promoter:
         GR   STAT1   p53   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFRSF4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36

TNFRSF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001136:  view genomic region     (about GC identifiers)

Start:
1,146,706 bp from pter      End:
1,149,548 bp from pter
Size:
2,843 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNR4_HUMAN, P43489 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 4 precursor  
Size: 277 amino acids; 29341 Da
Subunit: Interacts with TRAF2, TRAF3 and TRAF5
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAB33944.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for TNFRSF4:
1D0A (3D)        2HEV (3D)        2HEY (3D)    
Secondary accessions: Q13663 Q2M312 Q5T7M0

Explore the universe of human proteins at neXtProt for TNFRSF4: NX_P43489

Explore proteomics data for TNFRSF4 at MOPED 

TNFRSF4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TNFRSF4 Protein Expression

REFSEQ proteins: NP_003318.1  
ENSEMBL proteins: 
 ENSP00000368538  

Human Recombinant Protein Products for TNFRSF4: 
Browse Purified and Recombinant Proteins at EMD Millipore
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OriGene Protein Over-expression Lysate for TNFRSF4
OriGene MassSpec for TNFRSF4 
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GenScript Custom Purified and Recombinant Proteins Services for TNFRSF4
Novus Biologicals TNFRSF4 Proteins
Novus Biologicals TNFRSF4 Lysate
Sino Biological Recombinant Protein for TNFRSF4
Sino Biological Cell Lysate for TNFRSF4 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for TNFRSF4 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane ----
GO:0005887integral to plasma membrane TAS7510240
GO:0009897external side of plasma membrane IEA--
GO:0009986cell surface ISS--

TNFRSF4 for ontologies           About GeneDecksing



TNFRSF4 Antibody Products: 
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Assay Products for TNFRSF4: 
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Cloud-Clone Corp. ELISAs for TNFRSF4 
Cloud-Clone Corp. CLIAs for TNFRSF4


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CD: CD molecules
TNFRSF: Tumor necrosis factor receptor superfamily

IUPHAR Guide to PHARMACOLOGY protein family classification: OX40 
Tumour necrosis factor (TNF) receptor family

2 InterPro protein domains:
 IPR001368 TNFR/NGFR_Cys_rich_reg
 IPR020445 TNFR_4

Graphical View of Domain Structure for InterPro Entry P43489

ProtoNet protein and cluster: P43489

1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNR4_HUMAN, P43489
Similarity: Contains 4 TNFR-Cys repeats


TNFRSF4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TNR4_HUMAN, P43489
Function: Receptor for TNFSF4/OX40L/GP34

     Genatlas biochemistry entry for TNFRSF4:
tumor necrosis factor receptor superfamily,member 4,tax-transcriptionally activated glycoprotein 1 receptor

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005031tumor necrosis factor-activated receptor activity IEA--
GO:0005515protein binding ----
     
TNFRSF4 for ontologies           About GeneDecksing


Phenotypes:
     8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tnfrsf4):
 cellular  digestive/alimentary  growth/size  hematopoietic system  immune system 
 liver/biliary system  normal  respiratory system 

TNFRSF4 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for TNFRSF4: Tnfrsf4tm1Nik Tnfrsf4tm1Mfb

   inGenious Targeting Laboratory - Custom generated mouse model solutions for TNFRSF4 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNFRSF4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF4 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF4 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFRSF4
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SwitchGear 3'UTR luciferase reporter plasmidTNFRSF4 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of TNFRSF4

Clone
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OriGene clones in human, mouse for TNFRSF4 (see all 6)
OriGene ORF clones in mouse, rat for TNFRSF4
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GenScript: all cDNA clones in your preferred vector: TNFRSF4 (NM_003327)
Sino Biological Human cDNA Clone for TNFRSF4
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF4
Sirion Biotech Customized lentivirus for stable overexpression of TNFRSF4 
                     Customized lentivirus expression plasmids for stable overexpression of TNFRSF4 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF4


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TNFRSF4 About   (see all 9)                                                                                              See pathways by source

SuperPathContained pathways About
1TNF Signaling
TNF Signaling0.50
TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.49
Death Receptor Signaling0.50
NF-kB (NFkB) Pathway0.46
2PEDF Induced Signaling
STAT3 Pathway0.47
Cytokine-cytokine receptor interaction0.43
3Akt Signaling
Akt Signaling0.60
Tec Kinases Signaling0.55
p38 Signaling0.60
4PAK Pathway
Antioxidant Action of Vitamin-C0.56
5Rho Family GTPases
Molecular Mechanisms of Cancer0.51

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for TNFRSF4
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

1 R&D Systems Pathway for TNFRSF4
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF4 (see all 8)
    STAT3 Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
Tec Kinases Signaling
OX40 Pathway

1 GeneGo (Thomson Reuters) Pathway for TNFRSF4
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

1 BioSystems Pathway for TNFRSF4
    Downstream signaling in naive CD8+ T cells

3 Sino Biological Pathways for TNFRSF4 
    TNF Signaling
Death Receptor Signaling
NF-kB (NFkB) Pathway


1         Kegg Pathway  (Kegg details for TNFRSF4):
    Cytokine-cytokine receptor interaction


TNFRSF4 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF4

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/12 Interacting proteins for TNFRSF4 (P434893 ENSP000003685384) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
InteractantInteraction Details
GeneCardExternal ID(s)
TRAF5O004633, ENSP000002614644I2D: score=4 STRING: ENSP00000261464
TNFRSF9Q070113, ENSP000003667294I2D: score=3 STRING: ENSP00000366729
SIVA1O153043, ENSP000003292134I2D: score=2 STRING: ENSP00000329213
TNFSF4P235103, ENSP000002818344I2D: score=2 STRING: ENSP00000281834
TRAF1Q130773, ENSP000003629944I2D: score=4 STRING: ENSP00000362994
About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006954inflammatory response IEA--
GO:0006955immune response TAS7510240
GO:0006968cellular defense response IEA--
GO:0030890positive regulation of B cell proliferation ISS--
GO:0033209tumor necrosis factor-mediated signaling pathway ----

TNFRSF4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TNFRSF4 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNFRSF4 (TNR4)

1 IUPHAR Ligand for TNFRSF4 (OX40)    About this table 
LigandTypeActionAffinityPubmed IDs
OX-40 ligand
NoneNone--

2 Novoseek inferred chemical compound relationships for TNFRSF4 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
ionomycin 14.6 1 9766631 (1)
cyclosporin a 3.8 7 12296857 (2), 9766631 (1), 15808546 (1)

Search CenterWatch for drugs/clinical trials and news about TNFRSF4 / TNR4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNFRSF4 gene: 
NM_003327.3  

Unigene Cluster for TNFRSF4:

Tumor necrosis factor receptor superfamily, member 4
Hs.129780  [show with all ESTs]
Unigene Representative Sequence: NM_003327
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000379236(uc001ade.3) ENST00000497869(uc001adf.3) ENST00000453580

Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFRSF4
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TNFRSF4
SwitchGear 3'UTR luciferase reporter plasmidTNFRSF4 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for TNFRSF4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFRSF4
Clone
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OriGene ORF clones in mouse, rat for TNFRSF4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TNFRSF4 (NM_003327)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF4
Sirion Biotech Customized lentivirus for stable overexpression of TNFRSF4 
                     Customized lentivirus expression plasmids for stable overexpression of TNFRSF4 
Primer
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OriGene qPCR primer pairs and template standards for TNFRSF4
OriGene qSTAR qPCR primer pairs in human, mouse for TNFRSF4
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNFRSF4
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF4

Additional mRNA sequence: 

BC105070.1 BC105072.1 S76792.1 

3 DOTS entries:

DT.305181  DT.100731762  DT.101979188 

1 AceView cDNA sequence:

X75962 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNFRSF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CATACCTCCT
TNFRSF4 Expression
About this image


See TNFRSF4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFRSF4

SOURCE GeneReport for Unigene cluster: Hs.129780
    SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF4 (see all 8): 
          Cell Surface Markers in human mouse rat
          Th1/Th2 Response in human mouse rat
          TNF Ligands & Receptors in human mouse rat
          T-Cell Anergy & Immune Tolerance in human mouse rat
          Necrosis in human mouse rat

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF4 gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tnfrsf41 , 5 tumor necrosis factor receptor superfamily, member 4 less1, 5 71.28(n)1
65.38(a)1
  4 (87.68 cM)5
221631  NM_011659.21  NP_035789.11 
 1560138435 
chicken
(Gallus gallus)
Aves TNFRSF46
tumor necrosis factor receptor superfamily, member...
30(a)
1 ↔ 1
21(2547202-2552218)
lizard
(Anolis carolinensis)
Reptilia TNFRSF46
tumor necrosis factor receptor superfamily, member...
20(a)
1 ↔ 1
GL343647.1(363763-368985)


ENSEMBL Gene Tree for TNFRSF4 (if available)
TreeFam Gene Tree for TNFRSF4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/178 SNPs in TNFRSF4 are shown (see all 178)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs358877851,2
C,F--1146250(-) CTGAGC/TCCCGG 1 -- ds50015Minor allele frequency- T:0.00NS 188
rs356265751,2
C,F--1146276(-) CAGGCG/ACTGAC 1 -- ds50018Minor allele frequency- A:0.03NS WA EA 428
rs350384611,2
C,F--1146339(-) GGGAGC/TGGGGG 1 -- ds50017Minor allele frequency- T:0.02NS NA 312
rs22982081,2
C,F--1146399(+) GACCCC/TGCTAC 1 -- ds50016Minor allele frequency- T:0.04NS EA 310
rs345413811,2
C--1146418(-) GGCCAG/AGGTGG 1 -- ds50015Minor allele frequency- A:0.01NS 190
rs343083081,2
C,F--1146696(-) GGGCTG/ACACAC 1 -- ds50017Minor allele frequency- A:0.11NS CSA WA 309
rs355029611,2
C,F--1146710(-) CCGACC/TGGCAC 1 -- ut315Minor allele frequency- T:0.01NS 190
rs1490141081,2
--1146714(+) CGGTCA/GGAGAC 1 -- ut310--------
rs22982091,2
C,F,H--1146785(+) AAGCAG/CAGAGC 1 -- ut31 ese315Minor allele frequency- C:0.11EA NS NA WA 2456
rs22982101,2
C,F--1146853(+) CAGGCG/AGCCTG 1 -- ut31 ese38Minor allele frequency- A:0.01EA NS NA 1926

HapMap Linkage Disequilibrium report for TNFRSF4 (1146706 - 1149548 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/29 variations for TNFRSF4 (see all 29):    About this table     
Variant IDTypeSubtypePubMed ID
dgv24n71CNV Loss21882294
dgv17n71CNV Loss21882294
nsv470680CNV Loss18288195
nsv871680CNV Loss21882294
nsv482937CNV Loss15286789
nsv871512CNV Loss21882294
dgv12n71CNV Loss21882294
dgv25n71CNV Loss21882294
dgv21n71CNV Loss21882294
dgv19n71CNV Loss21882294


Human Gene Mutation Database (HGMD): TNFRSF4
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing TNFRSF4
DNA2.0 Custom Variant and Variant Library Synthesis for TNFRSF4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 600315    OMIM disorders: --

20/49 diseases for TNFRSF4 (see all 49):    About MalaCards
graft versus host disease    chronic graft versus host disease    acute graft versus host disease    hepatitis e
thymoma    graves' disease    cutaneous malignant melanoma    myasthenia gravis
hematopoietic stem cell transplantation    wegener's granulomatosis    goiter    adult t-cell leukemia
hiv type 1    cerebral infarction    polymyositis    lupus nephritis
encephalomyelitis    pertussis    ulcerative colitis    inflammatory bowel disease

1 disease from the University of Copenhagen DISEASES database for TNFRSF4:
Hepatitis E

TNFRSF4 for disorders           About GeneDecksing

10/22 Novoseek inferred disease relationships for TNFRSF4 gene (see all 22)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis 58.4 54 9488716 (2), 15591118 (2), 10483869 (1), 16443547 (1) (see all 34)
graft-versus-host disease 49.3 7 15808546 (2), 10373067 (1), 16367941 (1), 15591118 (1)
autoimmune diseases 46.4 3 11470287 (1), 9547794 (1), 11809163 (1)
autoimmunity 45 4 18197805 (2), 20510730 (1), 9766631 (1)
goiter nodular 42.3 2 16232366 (1), 16459462 (1)
tumors 41.9 70 16148096 (5), 16634867 (3), 9324133 (2), 9488716 (2) (see all 38)
leukemia t-cell 40.5 2 8613423 (2)
acute graft-versus-host disease 27.4 2 10373067 (1)
rheumatoid arthritis 26.3 2 16367941 (1)
myasthenia gravis 25.5 3 11071109 (1), 16367941 (1)

Genetic Association Database (GAD): TNFRSF4
Human Genome Epidemiology (HuGE) Navigator: TNFRSF4 (12 documents)

Export disorders for TNFRSF4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TNFRSF4 gene, integrated from 9 sources (see all 182):
(articles sorted by number of sources associating them with TNFRSF4)
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  1. The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen. (PubMed id 7510240)1, 2, 3, 9 Latza U.... Stein H. (1994)
  2. The HTLV-I protein transcriptionally modulates OX40 antigen expression. (PubMed id 10861060)1, 2, 9 Pankow R....Bulfone-Paus S. (2000)
  3. Human genetic evidence that OX40 is implicated in myocardial infarction. (PubMed id 16329997)1, 4, 9 Ria M....Lagercrantz J. (2006)
  4. Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5- mediated NF-kappaB activation. (PubMed id 9488716)1, 2, 9 Kawamata S.... Uchiyama T. (1998)
  5. Common polymorphisms in ITGA2, PON1 and THBS2 are ass ociated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (2010)
  6. [Association of rs2298212 polymorphism in OX40 gene w ith coronary atherosclerotic disease in Chinese Han population] (PubMed id 20376799)1, 4 Cheng G.H....Liu Q.J. (2010)
  7. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
  8. Association of TNFRSF4 gene polymorphisms with essential hypertension. (PubMed id 18398332)1, 4 Mashimo Y....Hata A. (2008)
  9. [Correlation of OX40 gene rs17568A/G polymorphism with acute coronary syndrome in Chinese Han population] (PubMed id 18798503)1, 4 Chen Y.C....Zeng Z. (2008)
  10. Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. (PubMed id 18987746)1, 4 Kimman T.G....Kerkhof M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 7293 HGNC: 11918 AceView: TNFRSF4.1 Ensembl:ENSG00000186827 euGenes: HUgn7293
ECgene: TNFRSF4 Kegg: 7293 H-InvDB: TNFRSF4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TNFRSF4 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFRSF4 Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf4/

(Patent information from GeneIP,
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Patent Information for TNFRSF4 gene:
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