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TNFRSF4 Gene

protein-coding   GIFtS: 62
GCID: GC01M001136

Tumor Necrosis Factor Receptor Superfamily, Member 4


(Previous symbol: TXGP1L)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 41 2     CD1342
TXGP1L1 2 3 5     ATC35 Antigen2
ACT35 Antigen2 3     Lymphoid Activation Antigene ACT352
CD134 Antigen2 3     OX40 Antigen2
OX40L Receptor2 3     OX40 Cell Surface Antigen2
TAX Transcriptionally-Activated Glycoprotein 1 Receptor2 3     OX40 Homologue2
ACT352 5     Tax-Transcriptionally Activated Glycoprotein 1 Receptor2
IMD162 5     Tumor Necrosis Factor Receptor Superfamily Member 42
OX402 5     

External Ids:    HGNC: 119181   Entrez Gene: 72932   Ensembl: ENSG000001868277   OMIM: 6003155   UniProtKB: P434893   

Export aliases for TNFRSF4 gene to outside databases

Previous GC identifers: GC01M000673 GC01M000898 GC01M001023 GC01M001052 GC01M001186 GC01M000418


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFRSF4 Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to
activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice
suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus
suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as
well as in T cell-dependent B cell proliferation and differentiation. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFRSF4 Gene:
TNFRSF4 (tumor necrosis factor receptor superfamily, member 4) is a protein-coding gene. Diseases associated with TNFRSF4 include graft versus host disease, and acute graft versus host disease. GO annotations related to this gene include tumor necrosis factor-activated receptor activity.

UniProtKB/Swiss-Prot: TNR4_HUMAN, P43489
Function: Receptor for TNFSF4/OX40L/GP34

Gene Wiki entry for TNFRSF4 (CD134) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFRSF4 gene promoter:
         GR   STAT1   p53   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFRSF4 promoter sequence
   Search Chromatin IP Primers for TNFRSF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36

TNFRSF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001136:  view genomic region     (about GC identifiers)

Start:
1,146,706 bp from pter      End:
1,149,548 bp from pter
Size:
2,843 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TNR4_HUMAN, P43489 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 4 precursor  
Size: 277 amino acids; 29341 Da
Subunit: Interacts with TRAF2, TRAF3 and TRAF5
Sequence caution: Sequence=AAB33944.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for TNFRSF4:
1D0A (3D)        2HEV (3D)        2HEY (3D)    
Secondary accessions: Q13663 Q2M312 Q5T7M0

Explore the universe of human proteins at neXtProt for TNFRSF4: NX_P43489

Explore proteomics data for TNFRSF4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn146, Asn160

  • See TNFRSF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003318.1  
    ENSEMBL proteins: 
     ENSP00000368538  

    TNFRSF4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for TNFRSF4
    Cloud-Clone Corp. CLIAs for TNFRSF4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: OX40
    Tumour necrosis factor (TNF) receptor family

    2 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR020445 TNFR_4

    Graphical View of Domain Structure for InterPro Entry P43489

    ProtoNet protein and cluster: P43489

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNR4_HUMAN, P43489
    Similarity: Contains 4 TNFR-Cys repeats


    TNFRSF4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR4_HUMAN, P43489
    Function: Receptor for TNFSF4/OX40L/GP34

         Genatlas biochemistry entry for TNFRSF4:
    tumor necrosis factor receptor superfamily,member 4,tax-transcriptionally activated glycoprotein 1 receptor

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005031tumor necrosis factor-activated receptor activity IEA--
    GO:0005515protein binding ----
         
    TNFRSF4 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tnfrsf4):
     cellular  digestive/alimentary  growth/size/body  hematopoietic system  immune system 
     liver/biliary system  normal  respiratory system 

    TNFRSF4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TNFRSF4: Tnfrsf4tm1Nik Tnfrsf4tm1Mfb

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFRSF4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNFRSF4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNR4_HUMAN, P43489: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0005887integral component of plasma membrane TAS7510240
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface ISS--

    TNFRSF4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFRSF4 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    5ERK Signaling
    Molecular Mechanisms of Cancer0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFRSF4
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF4 (see all 8)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling
    OX40 Pathway

    1 GeneGo (Thomson Reuters) Pathway for TNFRSF4
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    1 BioSystems Pathway for TNFRSF4
        Downstream signaling in naive CD8+ T cells

    3 Sino Biological Pathways for TNFRSF4
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1 Kegg Pathway  (Kegg details for TNFRSF4):
        Cytokine-cytokine receptor interaction


    TNFRSF4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF4 (see all 8): 
              Cell Surface Markers in human mouse rat
              Th1/Th2 Response in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Necrosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFRSF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for TNFRSF4 (P434893 ENSP000003685384) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF5O004633, ENSP000002614644I2D: score=4 STRING: ENSP00000261464
    TNFRSF9Q070113, ENSP000003667294I2D: score=3 STRING: ENSP00000366729
    SIVA1O153043, ENSP000003292134I2D: score=2 STRING: ENSP00000329213
    TNFSF4P235103, ENSP000002818344I2D: score=2 STRING: ENSP00000281834
    TRAF1Q130773, ENSP000003629944I2D: score=4 STRING: ENSP00000362994
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0006955immune response TAS7510240
    GO:0006968cellular defense response IEA--
    GO:0030890positive regulation of B cell proliferation ISS--
    GO:0033209tumor necrosis factor-mediated signaling pathway ----

    TNFRSF4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFRSF4 (TNR4)

    1 IUPHAR Ligand for TNFRSF4 (OX40)    About this table
    LigandTypeActionAffinityPubmed IDs
    OX-40 ligand
    NoneNone--

    2 Novoseek inferred chemical compound relationships for TNFRSF4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ionomycin 14.6 1 9766631 (1)
    cyclosporin a 3.8 7 12296857 (2), 9766631 (1), 15808546 (1)



    TNFRSF4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TNFRSF4 gene: 
    NM_003327.3  

    Unigene Cluster for TNFRSF4:

    Tumor necrosis factor receptor superfamily, member 4
    Hs.129780  [show with all ESTs]
    Unigene Representative Sequence: NM_003327
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379236(uc001ade.3) ENST00000497869(uc001adf.3) ENST00000453580

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QuantiFast Probe-based Assays in human, mouse, rat TNFRSF4

    Additional mRNA sequence: 

    BC105070.1 BC105072.1 S76792.1 

    3 DOTS entries:

    DT.305181  DT.100731762  DT.101979188 

    1 AceView cDNA sequence:

    X75962 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFRSF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATACCTCCT
    TNFRSF4 Expression
    About this image

    TNFRSF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFRSF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.129780
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF4 (see all 8): 
              Cell Surface Markers in human mouse rat
              Th1/Th2 Response in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Necrosis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF4 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf41 , 5 tumor necrosis factor receptor superfamily, member 4 less1, 5 71.68(n)1
    65.04(a)1
      4 (87.68 cM)5
    221631  NM_011659.21  NP_035789.11 
     1560138435 
    chicken
    (Gallus gallus)
    Aves TNFRSF41 tumor necrosis factor receptor superfamily, member 4 less 44.9(n)
    37.14(a)
      101751037  XM_004947423.1  XP_004947480.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNFRSF46
    tumor necrosis factor receptor superfamily, member...
    27(a)
    1 ↔ 1
    GL343647.1(363763-368985)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tnfrsf41 tumor necrosis factor receptor superfamily, member 4 less 45.21(n)
    33.75(a)
      101734890  XM_004916536.1  XP_004916593.1 


    ENSEMBL Gene Tree for TNFRSF4 (if available)
    TreeFam Gene Tree for TNFRSF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFRSF4 (see all 178)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358877851,2
    C,F--1146250(-) CTGAGC/TCCCGG 1 -- ds50015Minor allele frequency- T:0.00NS 188
    rs356265751,2
    C,F--1146276(-) CAGGCG/ACTGAC 1 -- ds50018Minor allele frequency- A:0.03NS WA EA 428
    rs350384611,2
    C,F--1146339(-) GGGAGC/TGGGGG 1 -- ds50017Minor allele frequency- T:0.02NS NA 312
    rs22982081,2
    C,F--1146399(+) GACCCC/TGCTAC 1 -- ds50016Minor allele frequency- T:0.04NS EA 310
    rs345413811,2
    C--1146418(-) GGCCAG/AGGTGG 1 -- ds50015Minor allele frequency- A:0.01NS 190
    rs343083081,2
    C,F--1146696(-) GGGCTG/ACACAC 1 -- ds50017Minor allele frequency- A:0.11NS CSA WA 309
    rs355029611,2
    C,F--1146710(-) CCGACC/TGGCAC 1 -- ut315Minor allele frequency- T:0.01NS 190
    rs1490141081,2
    --1146714(+) CGGTCA/GGAGAC 1 -- ut310--------
    rs22982091,2
    C,F,H--1146785(+) AAGCAG/CAGAGC 1 -- ut31 ese315Minor allele frequency- C:0.11EA NS NA WA 2456
    rs22982101,2
    C,F--1146853(+) CAGGCG/AGCCTG 1 -- ut31 ese38Minor allele frequency- A:0.01EA NS NA 1926

    HapMap Linkage Disequilibrium report for TNFRSF4 (1146706 - 1149548 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TNFRSF4 (see all 29):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv24n71CNV Loss21882294
    dgv17n71CNV Loss21882294
    nsv470680CNV Loss18288195
    nsv871680CNV Loss21882294
    nsv482937CNV Loss15286789
    nsv871512CNV Loss21882294
    dgv12n71CNV Loss21882294
    dgv25n71CNV Loss21882294
    dgv21n71CNV Loss21882294
    dgv19n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): TNFRSF4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFRSF4
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFRSF4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600315   
    OMIM disorders: 615593  
    Selected diseases for TNFRSF4 (see all 57):    
    About MalaCards
    graft versus host disease    acute graft versus host disease    chronic graft versus host disease    cutaneous malignant melanoma
    thymoma    myasthenia gravis    htlv-1 associated myelopathy/tropical spastic paraparesis    hepatitis e
    graves' disease    htlv-1 associated myelopathy    wegener's granulomatosis    hematopoietic stem cell transplantation
    goiter    adult t-cell leukemia    tropical spastic paraparesis    polymyositis
    encephalomyelitis    lupus nephritis    spastic paraparesis    inflammatory bowel disease

    1 disease from the University of Copenhagen DISEASES database for TNFRSF4:
    Hepatitis E

    TNFRSF4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for TNFRSF4 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 58.4 54 9488716 (2), 15591118 (2), 10483869 (1), 16443547 (1) (see all 34)
    graft-versus-host disease 49.3 7 15808546 (2), 10373067 (1), 16367941 (1), 15591118 (1)
    autoimmune diseases 46.4 3 11470287 (1), 9547794 (1), 11809163 (1)
    autoimmunity 45 4 18197805 (2), 20510730 (1), 9766631 (1)
    goiter nodular 42.3 2 16232366 (1), 16459462 (1)
    tumors 41.9 70 16148096 (5), 16634867 (3), 9324133 (2), 9488716 (2) (see all 38)
    leukemia t-cell 40.5 2 8613423 (2)
    acute graft-versus-host disease 27.4 2 10373067 (1)
    rheumatoid arthritis 26.3 2 16367941 (1)
    myasthenia gravis 25.5 3 11071109 (1), 16367941 (1)

    Genetic Association Database (GAD): TNFRSF4
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF4 (12 documents)

    Export disorders for TNFRSF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFRSF4 gene, integrated from 10 sources (see all 186):
    (articles sorted by number of sources associating them with TNFRSF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen. (PubMed id 7510240)1, 2, 3, 9 Latza U.... Stein H. (Eur. J. Immunol. 1994)
    2. The HTLV-I protein transcriptionally modulates OX40 antigen expression. (PubMed id 10861060)1, 2, 9 Pankow R....Bulfone-Paus S. (J. Immunol. 2000)
    3. Human genetic evidence that OX40 is implicated in myocardial infarction. (PubMed id 16329997)1, 4, 9 Ria M....Lagercrantz J. (Biochem. Biophys. Res. Commun. 2006)
    4. Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5- mediated NF-kappaB activation. (PubMed id 9488716)1, 2, 9 Kawamata S.... Uchiyama T. (J. Biol. Chem. 1998)
    5. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    6. [Association of rs2298212 polymorphism in OX40 gene with coronary atherosclerotic disease in Chinese Han population]. (PubMed id 20376799)1, 4 Cheng G.H....Liu Q.J. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2010)
    7. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    8. Association of TNFRSF4 gene polymorphisms with essential hypertension. (PubMed id 18398332)1, 4 Mashimo Y....Hata A. (J. Hypertens. 2008)
    9. [Correlation of OX40 gene rs17568A/G polymorphism with acute coronary syndrome in Chinese Han population]. (PubMed id 18798503)1, 4 Chen Y.C....Zeng Z. (Sichuan Da Xue Xue Bao Yi Xue Ban 2008)
    10. Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. (PubMed id 18987746)1, 4 Kimman T.G....Kerkhof M. (PLoS ONE 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7293 HGNC: 11918 AceView: TNFRSF4.1 Ensembl:ENSG00000186827 euGenes: HUgn7293
    ECgene: TNFRSF4 Kegg: 7293 H-InvDB: TNFRSF4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNFRSF4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF4 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFRSF4 gene:
    Search GeneIP for patents involving TNFRSF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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