Aliases for TNFRSF4 Gene
External Ids for TNFRSF4 Gene
Previous HGNC Symbols for TNFRSF4 Gene
Previous GeneCards Identifiers for TNFRSF4 Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF4 Gene
TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4) is a Protein Coding gene. Diseases associated with TNFRSF4 include immunodeficiency 16 and tropical spastic paraparesis. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include tumor necrosis factor-activated receptor activity.
UniProtKB/Swiss-Prot for TNFRSF4 Gene
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.