TNFRSF25 Gene

Aliases
for TNFRSF25 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC01M006330 GC01M006117 GC01M006230 GC01M006455 GC01M005668

Summaries
for TNFRSF25 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for TNFRSF25 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10  NC_018912.2  NT_032977.10  

SwitchGear Promoter luciferase reporter plasmid: TNFRSF25 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF25

TNFRSF25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M006521:  view genomic region     (about GC identifiers)

Proteins
for TNFRSF25 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for TNFRSF25: NX_Q93038

Explore proteomics data for TNFRSF25 at MOPED

Post-translational modifications: 

TNFRSF25 Human Recombinant Protein Products:

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	antibodies-online proteins for TNFRSF25 (3 products)
	antibodies-online peptides for TNFRSF25

TNFRSF25 Antibody Products:

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	antibodies-online antibodies for TNFRSF25 (121 products)

TNFRSF25 Assay Products:

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	Cloud-Clone Corp. ELISAs for TNFRSF25 Cloud-Clone Corp. CLIAs for TNFRSF25
	Search eBioscience for ELISAs for TNFRSF25
	antibodies-online kits for TNFRSF25 (2 products)

Domains /
Families
for TNFRSF25 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q93038

Find genes that share domains with TNFRSF25           About GenesLikeMe

Function
for TNFRSF25 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Tnfrsf25)

genOway: Develop your customized and physiologically relevant rodent model for TNFRSF25

miRNA Products:		miRTarBase miRNAs that target TNFRSF25: hsa-mir-124-3p (MIRT022463)
		Block miRNA regulation of human, mouse, rat TNFRSF25 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TNFRSF25 (see all 10):
		hsa-miR-3163 hsa-miR-3618 hsa-miR-934 hsa-miR-2909 hsa-miR-3918 hsa-miR-374c hsa-miR-3158-3p hsa-miR-655
		SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF25 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TNFRSF25
		Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF25

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TNFRSF25

Clone Products:		OriGene clones in human, mouse for TNFRSF25 (see all 32) OriGene ORF clones in mouse, rat for TNFRSF25 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): TNFRSF25 (NM_003790)
		Sino Biological Human cDNA Clone for TNFRSF25
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF25
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF25

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TNFRSF25
		Browse ESI BIO Cell Lines and PureStem Progenitors for TNFRSF25

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF25

Localization
for TNFRSF25 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	5
extracellular	5
plasma membrane	5
endoplasmic reticulum	1
lysosome	1

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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for TNFRSF25 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for TNFRSF25 About   (see all 6)   See pathways by source

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	SuperPath	Contained pathways About
1	TNF Signaling	TNF Signaling 0.50 TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions 0.49 Death Receptor Signaling 0.50 NF-kB (NFkB) Pathway 0.46
2	Apoptosis Signaling Pathways	Apoptosis Signaling Pathways 0.35 Apoptosis and survival Apoptotic TNF-family pathways 0.35
3	Apoptosis (WikiPathways)	Apoptosis Modulation and Signaling 0.38 Apoptosis 0.38
4	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway 0.46
5	PEDF Induced Signaling	Cytokine-cytokine receptor interaction 0.43

2 R&D Systems Pathways for TNFRSF25

	TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
	Apoptosis Signaling Pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF25

	TWEAK Pathway
	STAT3 Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Glucocorticoid Receptor Signaling

1 Cell Signaling Technology (CST) Pathway for TNFRSF25

Apoptosis and Autophagy

2 GeneGo (Thomson Reuters) Pathways for TNFRSF25

	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
	Apoptosis and survival Apoptotic TNF-family pathways

2 BioSystems Pathways for TNFRSF25

	Apoptosis
	Apoptosis Modulation and Signaling

3 Sino Biological Pathways for TNFRSF25

	TNF Signaling
	Death Receptor Signaling
	NF-kB (NFkB) Pathway

1 Kegg Pathway  (Kegg details for TNFRSF25)

Cytokine-cytokine receptor interaction

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

Drugs & Compounds
for TNFRSF25 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for TNFRSF25 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for TNFRSF25 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TNFRSF25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGGCTGGACG

About this image

Blood (Cardiovascular System)    fully expand to see all 10 entries
T Helper Cells Peripheral Blood
Peripheral blood Pan-T Cells
cd4+ t cells
Thymus (Hematopoietic System)    fully expand to see all 3 entries
T Helper Cells Thymus
Umbilical Cord (Extraembryonic Tissues)
Cord Blood Pan-T Cells
Brain (Nervous System)
Cerebellum
Spleen (Hematopoietic System)

Primer Products:		OriGene qPCR primer pairs and template standards for TNFRSF25 OriGene qSTAR qPCR primer pairs in human, mouse for TNFRSF25
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNFRSF25
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		QuantiFast Probe-based Assays in human, mouse, rat TNFRSF25

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF25

Orthologs
for TNFRSF25 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for TNFRSF25 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for TNFRSF25 gene

TNFRSF1A²  

Find genes that share paralogs with TNFRSF25           About GenesLikeMe

Genomic Variants
for TNFRSF25 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TNFRSF25 (see all 188)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1406429351,2		--	6524252(+)	TAAGGC/TGGATC	6	--	int1 ut31		0	--	--	--	--
rs455998321,2	C,F	--	6524367(-)	TGGGGC/AAGGTG	6	--	int1 ut31		2		NS WA	284
rs1155393001,2	C	--	6524415(+)	CCATCC/TCACGA	6	--	int1 ut31		1		WA	118
rs1829220431,2	C	--	6524490(+)	GGTCCA/CACAGT	11	G W	mis1 int1		0	--	--	--	--
rs118004621,2,,4	C,F,A,H	--	6524501(+)	CAGTAT/CCTCTG	11	/D /G	mis1 int1		24		NS EA NA CSA WA EU	8137
rs1996348921,2	C	--	6524519(+)	CTGCAA/GTCCAG	6	--	int1		0	--	--	--	--
rs455586321,2	C	--	6524596(-)	CCACCC/TAGGGC	6	--	int1		1		NS	162
rs2016389461,2		--	6524600(+)	TGGGTA/GGGGGT	6	--	int1		0	--	--	--	--
rs773883721,2	C	--	6524639(+)	CAGGGC/GCCCGC	11	P A	mis1 int1		0	--	--	--	--
rs351372931,2	C,F	--	6524649(+)	CAGTCT/CAGGCA	11	/L	syn1 int1		8		NA NS CSA WA EU	5422

HapMap Linkage Disequilibrium report for TNFRSF25 (6521211 - 6526255 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for TNFRSF25 (see all 19):    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv508836	CNV	Insertion	20534489
nsv470691	CNV	Loss	18288195
nsv871698	CNV	Loss	21882294
nsv462061	CNV	Loss	19166990
nsv871719	CNV	Loss	21882294
nsv870465	CNV	Loss	21882294
dgv127n71	CNV	Loss	21882294
dgv119n71	CNV	Loss	21882294
dgv125n71	CNV	Loss	21882294
nsv831536	CNV	Loss	17160897

Human Gene Mutation Database (HGMD): TNFRSF25

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TNFRSF25

DNA2.0 Custom Variant and Variant Library Synthesis for TNFRSF25

Disorders / Diseases
for TNFRSF25 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

1 disease for TNFRSF25

2 Novoseek inferred disease relationships for TNFRSF25 gene    About this table

Publications
for TNFRSF25 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). (PubMed id 9052839)^{1, 2, 3} Bodmer J.-L.... Tschopp J. (Immunity 1997)
2. A death-domain-containing receptor that mediates apoptosis. (PubMed id 8934525)^{1, 2, 3} Kitson J.... Farrow S.N. (Nature 1996)
3. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. (PubMed id 8875942)^{1, 2, 9} Chinnaiyan A.M.... Dixit V.M. (Science 1996)
4. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)^{1, 4} Lee K.M....Lan Q. (Am. J. Hematol. 2010)
5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)^{1, 4} Hosgood H.D....Lan Q. (Occup Environ Med 2009)
6. An unappreciated role for RNA surveillance. (PubMed id 14759258)^{1, 2} Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
7. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PubMed id 15301860)^{1, 4} Cho S.M....Lee J.K. (Hum. Immunol. 2004)
8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (Genome Res. 2003)
9. Relationship of large multifunctional proteasome 7 gene polymorphism with susceptibility to type 1 diabetes mellitus and DR3 gene. (PubMed id 11793848)^{1, 4} Ding H....Yang G. (Chin. Med. J. 2001)
10. The relationship of lmp2 and DR3 genes with susceptibility to type I diabetes mellitus in south China Han population. (PubMed id 11819535)^{1, 4} Ding H.L....Yan T. (World J. Gastroenterol. 2000)

External Searches for TNFRSF25 gene

Genome Databases showing TNFRSF25 gene

Other Databases showing TNFRSF25 gene

Specialized Databases showing TNFRSF25 gene

Products
for TNFRSF25 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section