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Aliases for TNFRSF25 Gene

Aliases for TNFRSF25 Gene

  • TNF Receptor Superfamily Member 25 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 12 (Translocating Chain-Association Membrane Protein) 2 3
  • Lymphocyte-Associated Receptor Of Death 3 4
  • Apoptosis-Mediating Receptor TRAMP 3 4
  • Apoptosis-Mediating Receptor DR3 3 4
  • Apoptosis-Inducing Receptor AIR 3 4
  • Protein WSL-1 3 4
  • TNFRSF12 3 4
  • APO-3 3 4
  • DDR3 3 4
  • LARD 3 4
  • DR3 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 25 2
  • Tumor Necrosis Factor Receptor Superfamily Member 25 3
  • Death Domain Receptor 3 Soluble Form 3
  • Apoptosis Inducing Receptor 3
  • Death Receptor Beta 3
  • Death Receptor 3 4
  • Protein WSL 4
  • WSL-LR 3
  • TRAMP 3
  • WSL-1 3
  • APO3 4
  • WSL1 4
  • TR3 3
  • WSL 4

External Ids for TNFRSF25 Gene

Previous HGNC Symbols for TNFRSF25 Gene

  • TNFRSF12

Previous GeneCards Identifiers for TNFRSF25 Gene

  • GC01M006330
  • GC01M006117
  • GC01M006230
  • GC01M006455
  • GC01M005668

Summaries for TNFRSF25 Gene

Entrez Gene Summary for TNFRSF25 Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF25 Gene

TNFRSF25 (TNF Receptor Superfamily Member 25) is a Protein Coding gene. Diseases associated with TNFRSF25 include Punctate Epithelial Keratoconjunctivitis and Juvenile Dermatitis Herpetiformis. Among its related pathways are TRAF Pathway and PEDF Induced Signaling. GO annotations related to this gene include receptor activity and tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF1A.

UniProtKB/Swiss-Prot for TNFRSF25 Gene

  • Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.

Gene Wiki entry for TNFRSF25 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF25 Gene

Genomics for TNFRSF25 Gene

Regulatory Elements for TNFRSF25 Gene

Enhancers for TNFRSF25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G005990 1.8 FANTOM5 ENCODE dbSUPER 21.2 +473.0 473028 4.6 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A ZNF766 ZNF143 ZNF207 TNFRSF25 NPHP4 PHF13 ZBTB48 KCNAB2 CHD5 GC01M006038
GH01G006487 1.6 Ensembl ENCODE dbSUPER 20.8 -24.4 -24363 6.0 HDGF AGO1 ARID4B FEZF1 DMAP1 ZNF2 ZNF143 FOS ZNF263 SP3 PLEKHG5 TNFRSF25 KLHL21 PHF13 THAP3 ESPN
GH01G006024 1.7 FANTOM5 ENCODE dbSUPER 3.1 +438.8 438837 5.3 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF48 ZNF121 ELK1 KCNAB2 NPHP4 TNFRSF25 GC01M006038
GH01G006464 1.2 Ensembl ENCODE dbSUPER 0.7 +0.8 775 2.6 CTCF KLF1 SAP130 ARID4B ZIC2 RAD21 GATA2 POLR2A SMC3 GATAD2A ESPN TNFRSF25 ENSG00000231868
GH01G006446 1.5 Ensembl ENCODE dbSUPER 0.4 +17.2 17200 6.3 ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 GLIS2 SP3 SP5 ZHX2 ESPN PLEKHG5 RPL22 RNF207 LOC102724450 ACOT7 ENSG00000231868 TNFRSF25
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFRSF25 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TNFRSF25 gene promoter:

Genomic Location for TNFRSF25 Gene

Chromosome:
1
Start:
6,461,151 bp from pter
End:
6,466,195 bp from pter
Size:
5,045 bases
Orientation:
Minus strand

Genomic View for TNFRSF25 Gene

Genes around TNFRSF25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF25 Gene

Proteins for TNFRSF25 Gene

  • Protein details for TNFRSF25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93038-TNR25_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 25
    Protein Accession:
    Q93038
    Secondary Accessions:
    • B1ALX2
    • B1ALX3
    • B7ZLL7
    • O00275
    • O00276
    • O00277
    • O00278
    • O00279
    • O00280
    • O14865
    • O14866
    • P78507
    • P78515
    • Q17RU4
    • Q92983
    • Q93036
    • Q93037
    • Q99722
    • Q99830
    • Q99831
    • Q9BY86
    • Q9UME0
    • Q9UME1
    • Q9UME5

    Protein attributes for TNFRSF25 Gene

    Size:
    417 amino acids
    Molecular mass:
    45385 Da
    Quaternary structure:
    • Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.

    Alternative splice isoforms for TNFRSF25 Gene

neXtProt entry for TNFRSF25 Gene

Post-translational modifications for TNFRSF25 Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF25 (DR3/TNFRSF25)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF25 (TNFRSF25)
  • Abcam antibodies for TNFRSF25

No data available for DME Specific Peptides for TNFRSF25 Gene

Domains & Families for TNFRSF25 Gene

Gene Families for TNFRSF25 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFRSF25: view

No data available for UniProtKB/Swiss-Prot for TNFRSF25 Gene

Function for TNFRSF25 Gene

Molecular function for TNFRSF25 Gene

UniProtKB/Swiss-Prot Function:
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.

Gene Ontology (GO) - Molecular Function for TNFRSF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity NAS 9114039
GO:0005031 tumor necrosis factor-activated receptor activity TAS 9052839
genes like me logo Genes that share ontologies with TNFRSF25: view
genes like me logo Genes that share phenotypes with TNFRSF25: view

Animal Models for TNFRSF25 Gene

MGI Knock Outs for TNFRSF25:

Animal Model Products

  • Taconic Biosciences Mouse Models for TNFRSF25

CRISPR Products

miRNA for TNFRSF25 Gene

miRTarBase miRNAs that target TNFRSF25

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF25 Gene

Localization for TNFRSF25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF25 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 9: Cell membrane; Single-pass type I membrane protein.
Isoform 11: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.
Isoform 4: Secreted.
Isoform 5: Secreted.
Isoform 6: Secreted.
Isoform 7: Secreted.
Isoform 8: Secreted.
Isoform 10: Secreted.
Isoform 12: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF25 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
nucleus 2
endoplasmic reticulum 2
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TNFRSF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005829 cytosol NAS 9114039
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9052839
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF25: view

Pathways & Interactions for TNFRSF25 Gene

genes like me logo Genes that share pathways with TNFRSF25: view

SIGNOR curated interactions for TNFRSF25 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TNFRSF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS,NAS 9114039
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007165 signal transduction TAS 8875942
GO:0007166 cell surface receptor signaling pathway TAS 9052839
genes like me logo Genes that share ontologies with TNFRSF25: view

Drugs & Compounds for TNFRSF25 Gene

(1) Drugs for TNFRSF25 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TL1A Pharma 0
genes like me logo Genes that share compounds with TNFRSF25: view

Transcripts for TNFRSF25 Gene

Unigene Clusters for TNFRSF25 Gene

Tumor necrosis factor receptor superfamily, member 25:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF25 Gene

No ASD Table

Relevant External Links for TNFRSF25 Gene

GeneLoc Exon Structure for
TNFRSF25
ECgene alternative splicing isoforms for
TNFRSF25

Expression for TNFRSF25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF25 Gene

This gene is overexpressed in Brain - Cerebellum (x9.3) and Brain - Cerebellar Hemisphere (x8.5).

Protein differential expression in normal tissues from HIPED for TNFRSF25 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF25 Gene



Protein tissue co-expression partners for TNFRSF25 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF25 Gene:

TNFRSF25

SOURCE GeneReport for Unigene cluster for TNFRSF25 Gene:

Hs.462529

mRNA Expression by UniProt/SwissProt for TNFRSF25 Gene:

Q93038-TNR25_HUMAN
Tissue specificity: Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.

Evidence on tissue expression from TISSUES for TNFRSF25 Gene

  • Nervous system(4.5)
  • Heart(4.3)
  • Lung(4.3)
  • Blood(2.8)
  • Skin(2.8)
  • Thyroid gland(2.5)
  • Intestine(2.4)
  • Spleen(2.4)
  • Lymph node(2.2)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with TNFRSF25: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF25 Gene

Orthologs for TNFRSF25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF25 35 34
  • 96.25 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TNFRSF25 35 34
  • 80.53 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TNFRSF25 34 35
  • 78.35 (n)
mouse
(Mus musculus)
Mammalia Tnfrsf25 35 16 34
  • 75.7 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfrsf25 34
  • 73.67 (n)
oppossum
(Monodelphis domestica)
Mammalia TNFRSF25 35
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFRSF25 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNFRSF25 34 35
  • 54.17 (n)
zebrafish
(Danio rerio)
Actinopterygii TNFRSF25 35
  • 22 (a)
OneToOne
Species where no ortholog for TNFRSF25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF25 Gene

ENSEMBL:
Gene Tree for TNFRSF25 (if available)
TreeFam:
Gene Tree for TNFRSF25 (if available)

Paralogs for TNFRSF25 Gene

Paralogs for TNFRSF25 Gene

genes like me logo Genes that share paralogs with TNFRSF25: view

Variants for TNFRSF25 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF25 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs114619322 Likely benign 6,468,009(+) GCAGC(C/G)GACTA intron-variant, upstream-variant-2KB, reference, missense
rs3176900 Likely benign 6,466,866(-) CCACA(C/T)TCAGG upstream-variant-2KB, utr-variant-3-prime
rs45574533 Likely benign 6,466,250(-) GGGCT(C/T)GGGCG upstream-variant-2KB, utr-variant-3-prime
rs45604837 Likely benign 6,466,259(-) GACTC(A/G)GTTGG upstream-variant-2KB, utr-variant-3-prime
rs538175057 Likely benign 6,466,798(+) GTATT(A/T)AAAAA upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF25 Gene

Variant ID Type Subtype PubMed ID
dgv2n27 CNV loss 19166990
dgv80n54 CNV loss 21841781
dgv9n67 CNV gain 20364138
esv25412 CNV gain+loss 19812545
nsv1009548 CNV loss 25217958
nsv462061 CNV loss 19166990
nsv470690 CNV gain 18288195
nsv470691 CNV loss 18288195
nsv508836 CNV insertion 20534489
nsv545240 CNV loss 21841781
nsv545264 CNV loss 21841781
nsv545265 CNV loss 21841781
nsv545266 CNV loss 21841781
nsv7880 CNV gain+loss 18304495
nsv831536 CNV loss 17160897
nsv954048 CNV deletion 24416366

Variation tolerance for TNFRSF25 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 65.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF25 Gene

Human Gene Mutation Database (HGMD)
TNFRSF25
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF25 Gene

Disorders for TNFRSF25 Gene

MalaCards: The human disease database

(29) MalaCards diseases for TNFRSF25 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFRSF25

Genetic Association Database (GAD)
TNFRSF25
Human Genome Epidemiology (HuGE) Navigator
TNFRSF25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFRSF25
genes like me logo Genes that share disorders with TNFRSF25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF25 Gene

Publications for TNFRSF25 Gene

  1. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). (PMID: 9052839) Bodmer J.-L. … Tschopp J. (Immunity 1997) 2 3 4 64
  2. A death-domain-containing receptor that mediates apoptosis. (PMID: 8934525) Kitson J. … Farrow S.N. (Nature 1996) 2 3 4 64
  3. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. (PMID: 8875942) Chinnaiyan A.M. … Dixit V.M. (Science 1996) 3 4 22 64
  4. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee K.M. … Lan Q. (Am. J. Hematol. 2010) 3 46 64
  5. Immunology: TL1A in the inflammatory network in autoimmune diseases. (PMID: 20125169) Bayry J. (Nat Rev Rheumatol 2010) 3 22 64

Products for TNFRSF25 Gene

Sources for TNFRSF25 Gene

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