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TNFRSF25 Gene

protein-coding   GIFtS: 63
GCID: GC01M006521

Tumor Necrosis Factor Receptor Superfamily, Member 25

(Previous names: tumor necrosis factor receptor superfamily, member 12 (translocating...)
(Previous symbol: TNFRSF12)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 251 2     TRAMP2
TNFRSF121 2 3 5     WSL-12
DR32 3 5     WSL-LR2
LARD2 3 5     Apoptosis Inducing Receptor2
Tumor Necrosis Factor Receptor Superfamily, Member 12 (Translocating
Chain-Association Membrane Protein)1 2
     Death Domain Receptor 3 Soluble Form2
Apoptosis-Inducing Receptor AIR2 3     Death Receptor Beta2
Apoptosis-Mediating Receptor DR32 3     Tumor Necrosis Factor Receptor Superfamily Member 252
Apoptosis-Mediating Receptor TRAMP2 3     APO33
Lymphocyte-Associated Receptor Of Death2 3     Apo-33
Protein WSL-12 3     WSL3
DDR32 3     WSL13
APO-32     Death Receptor 33
TR32     Protein WSL3

External Ids:    HGNC: 119101   Entrez Gene: 87182   Ensembl: ENSG000002157887   OMIM: 6033665   UniProtKB: Q930383   

Export aliases for TNFRSF25 gene to outside databases

Previous GC identifers: GC01M006330 GC01M006117 GC01M006230 GC01M006455 GC01M005668


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFRSF25 Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed
preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte
homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The
signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout
studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple
alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of
which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a
programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and
is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TNFRSF25 Gene:
TNFRSF25 (tumor necrosis factor receptor superfamily, member 25) is a protein-coding gene. Diseases associated with TNFRSF25 include immunoglobulin alpha deficiency, and hypersensitivity reaction type ii disease. GO annotations related to this gene include tumor necrosis factor-activated receptor activity and receptor activity. An important paralog of this gene is TNFRSF1A.

UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038
Function: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of
NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis

Gene Wiki entry for TNFRSF25 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFRSF25 gene promoter:
         p53   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFRSF25 promoter sequence
   Search Chromatin IP Primers for TNFRSF25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2   Ensembl cytogenetic band:  1p36.31   HGNC cytogenetic band: 1p36.2

TNFRSF25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF25 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M006521:  view genomic region     (about GC identifiers)

Start:
6,521,211 bp from pter      End:
6,526,255 bp from pter
Size:
5,045 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 25 precursor  
Size: 417 amino acids; 45385 Da
Subunit: Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two
distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4
Secondary accessions: B1ALX2 B1ALX3 B7ZLL7 O00275 O00276 O00277 O00278 O00279 O00280 O14865
O14866 P78507 P78515 Q17RU4 Q92983 Q93036 Q93037 Q99722 Q99830 Q99831 Q9BY86 Q9UME0 Q9UME1
Q9UME5
Alternative splicing: 12 isoforms:  Q93038-1   Q93038-2   Q93038-3   Q93038-4   Q93038-5   Q93038-6   Q93038-7   Q93038-8   
Q93038-9   Q93038-10   Q93038-11   Q93038-12   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for TNFRSF25: NX_Q93038

Explore proteomics data for TNFRSF25 at MOPED

Post-translational modifications: 

  • Glycosylated (Probable)1
  • Glycosylation2 at Asn67, Asn106

  • See TNFRSF25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001034753.1  NP_003781.1  NP_683866.1  NP_683867.1  NP_683868.1  NP_683871.1  

    ENSEMBL proteins: 
     ENSP00000431554   ENSP00000434129   ENSP00000367013   ENSP00000349341   ENSP00000337713  
     ENSP00000404274   ENSP00000326762   ENSP00000314451   ENSP00000423121   ENSP00000421976  
     ENSP00000424071   ENSP00000465381  

    TNFRSF25 Human Recombinant Protein Products:

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    Novus Biologicals TNFRSF25 Lysate
    Sino Biological Recombinant Protein for TNFRSF25
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    TNFRSF25 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: death receptor 3
    Tumour necrosis factor (TNF) receptor family

    4 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR011029 DEATH-like_dom
     IPR000488 Death_domain
     IPR022329 TNFR_25

    Graphical View of Domain Structure for InterPro Entry Q93038

    ProtoNet protein and cluster: Q93038

    2 Blocks protein domains:
    IPB000488 Death domain
    IPB001368 TNFR/CD27/30/40/95 cysteine-rich region


    UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038
    Similarity: Contains 1 death domain
    Similarity: Contains 4 TNFR-Cys repeats


    TNFRSF25 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR25_HUMAN, Q93038
    Function: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of
    NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity NAS9114039
    GO:0005031tumor necrosis factor-activated receptor activity TAS9052839
    GO:0005515protein binding ----
         
    TNFRSF25 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tnfrsf25):
     cellular  hematopoietic system  immune system 

    TNFRSF25 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFRSF25
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF25
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF25

    miRNA
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    miRTarBase miRNAs that target TNFRSF25:
    hsa-mir-124-3p (MIRT022463)

    Block miRNA regulation of human, mouse, rat TNFRSF25 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNFRSF25 (see all 10):
    hsa-miR-3163 hsa-miR-3618 hsa-miR-934 hsa-miR-2909 hsa-miR-3918 hsa-miR-374c hsa-miR-3158-3p hsa-miR-655
    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF25 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF25

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    GenScript: all cDNA clones in your preferred vector (see all 6): TNFRSF25 (NM_003790)
    Sino Biological Human cDNA Clone for TNFRSF25
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF25

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF25


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNR25_HUMAN, Q93038: Isoform 1: Cell membrane; Single-pass type I membrane protein
    TNR25_HUMAN, Q93038: Isoform 2: Cell membrane; Single-pass type I membrane protein
    TNR25_HUMAN, Q93038: Isoform 9: Cell membrane; Single-pass type I membrane protein
    TNR25_HUMAN, Q93038: Isoform 11: Cell membrane; Single-pass type I membrane protein
    TNR25_HUMAN, Q93038: Isoform 3: Secreted
    TNR25_HUMAN, Q93038: Isoform 4: Secreted
    TNR25_HUMAN, Q93038: Isoform 5: Secreted
    TNR25_HUMAN, Q93038: Isoform 6: Secreted
    TNR25_HUMAN, Q93038: Isoform 7: Secreted
    TNR25_HUMAN, Q93038: Isoform 8: Secreted
    TNR25_HUMAN, Q93038: Isoform 10: Secreted
    TNR25_HUMAN, Q93038: Isoform 12: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular5
    plasma membrane5
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005829cytosol NAS9114039
    GO:0005886plasma membrane IDA11911831
    GO:0005887integral component of plasma membrane TAS9052839

    TNFRSF25 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFRSF25 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2Apoptosis Signaling Pathways
    Apoptosis and survival Apoptotic TNF family pathways0.35
    Apoptosis Signaling Pathways0.35
    3Apoptosis (WikiPathways)
    Apoptosis0.38
    Apoptosis Modulation and Signaling0.38
    4Apoptosis and survival Anti apoptotic TNFs NF kB Bcl 2 pathway
    Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway0.46
    5PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for TNFRSF25
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF25 (see all 15)
        TWEAK Pathway
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Glucocorticoid Receptor Signaling

    1 Cell Signaling Technology (CST) Pathway for TNFRSF25
        Apoptosis and Autophagy

    2 GeneGo (Thomson Reuters) Pathways for TNFRSF25
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival Apoptotic TNF-family pathways

    2 BioSystems Pathways for TNFRSF25
        Apoptosis
    Apoptosis Modulation and Signaling

    3 Sino Biological Pathways for TNFRSF25
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1 Kegg Pathway  (Kegg details for TNFRSF25):
        Cytokine-cytokine receptor interaction


    TNFRSF25 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF25: 
              TNF Ligands & Receptors in human mouse rat
              Neurotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat
              Necrosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFRSF25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for TNFRSF25 (Q930383 ENSP000003670134) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRADDQ156283, ENSP000003412684I2D: score=3 STRING: ENSP00000341268
    BAG4O954293, ENSP000002873224I2D: score=2 STRING: ENSP00000287322
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    NOL3O609363, ENSP000002686054I2D: score=1 STRING: ENSP00000268605
    TNFSF15O951503, ENSP000003631574I2D: score=2 STRING: ENSP00000363157
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process NAS9114039
    GO:0007165signal transduction TAS8875942
    GO:0007166cell surface receptor signaling pathway TAS9052839
    GO:0033209tumor necrosis factor-mediated signaling pathway TAS9052839
    GO:0042981regulation of apoptotic process NAS9114039

    TNFRSF25 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFRSF25 (TNR25)

    1 IUPHAR Ligand for TNFRSF25 (death receptor 3)    About this table
    LigandTypeActionAffinityPubmed IDs
    TL1A
    NoneNone--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TNFRSF25 gene (9 alternative transcripts): 
    NM_001039664.1  NM_003790.2  NM_148965.1  NM_148966.1  NM_148967.1  NM_148970.1  NM_148968.1  NM_148969.1  
    NM_148974.1  

    Unigene Cluster for TNFRSF25:

    Tumor necrosis factor receptor superfamily, member 25
    Hs.462529  [show with all ESTs]
    Unigene Representative Sequence: Y09392
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000473343 ENST00000513135 ENST00000485036 ENST00000480393 ENST00000377782(uc001anh.3)
    ENST00000356876(uc001ana.3 uc001anb.3 uc001anc.3 uc001and.3 uc009vlz.3 uc001ane.3 uc001anf.3 uc001ang.3)
    ENST00000351959 ENST00000414040 ENST00000351748 ENST00000348333 ENST00000502588
    ENST00000502730 ENST00000510563 ENST00000453260 ENST00000475730 ENST00000469691
    ENST00000481401 ENST00000461703
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    hsa-miR-3163 hsa-miR-3618 hsa-miR-934 hsa-miR-2909 hsa-miR-3918 hsa-miR-374c hsa-miR-3158-3p hsa-miR-655
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      QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF25
      QuantiFast Probe-based Assays in human, mouse, rat TNFRSF25

    Additional mRNA sequence: 

    AB308321.1 AF026070.1 AY358309.1 BC117189.1 BC143886.1 U72763.1 U74611.1 U75380.1 
    U75381.1 U78029.1 U83597.1 U83598.1 U94501.1 U94502.1 U94508.1 U94509.1 
    U94510.1 U94511.1 U94512.1 Y09392.1 

    14 DOTS entries:

    DT.92431005  DT.86847342  DT.100790315  DT.99933149  DT.97763290  DT.100790318  DT.86847340  DT.121426091 
    DT.121426124  DT.75112427  DT.95250774  DT.101984073  DT.92005786  DT.99948401 

    Selected AceView cDNA sequences (see all 180):

    BM794760 BC042606 AI963243 AW050746 AB018263 AK024676 AK125550 U94506 
    U94501 AW134494 AK096347 NM_148965 AI805704 AK131074 NM_148973 NM_148974 
    U94502 Z39975 NM_198681 AK128021 NM_148971 BC015231 AW452241 AI275938 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFRSF25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTGGACG
    TNFRSF25 Expression
    About this image


    TNFRSF25 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 10 entries
             T Helper Cells Peripheral Blood
             Peripheral blood Pan-T Cells   
             cd4+ t cells   
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             T Helper Cells Thymus
     
     Umbilical Cord (Extraembryonic Tissues)
             Cord Blood Pan-T Cells   
     
     Brain (Nervous System)
             Cerebellum
     
     Spleen (Hematopoietic System)
    TNFRSF25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFRSF25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.462529

    UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038
    Tissue specificity: Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such
    as thymus, colon, intestine, and spleen. Also found in the prostate

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF25: 
              TNF Ligands & Receptors in human mouse rat
              Neurotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat
              Necrosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF25 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf251 , 5 tumor necrosis factor receptor superfamily, member more1, 5 75.7(n)1
    69.16(a)1
      4 (82.89 cM)5
    850301  NM_033042.31  NP_149031.21 
     1521159345 
    chicken
    (Gallus gallus)
    Aves TNFRSF251 tumor necrosis factor receptor superfamily, member more 54.17(n)
    42.9(a)
      425564  XM_423315.4  XP_423315.4 
    zebrafish
    (Danio rerio)
    Actinopterygii TNFRSF256
    tumor necrosis factor receptor superfamily, member...
    22(a)
    1 ↔ 1
    23(21060592-21068774) ENSDARG00000089868


    ENSEMBL Gene Tree for TNFRSF25 (if available)
    TreeFam Gene Tree for TNFRSF25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNFRSF25 gene
    TNFRSF1A2  

    TNFRSF25 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFRSF25 (see all 188)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406429351,2
    --6524252(+) TAAGGC/TGGATC 6 -- int1 ut310--------
    rs455998321,2
    C,F--6524367(-) TGGGGC/AAGGTG 6 -- int1 ut312Minor allele frequency- A:0.02NS WA 284
    rs1155393001,2
    C--6524415(+) CCATCC/TCACGA 6 -- int1 ut311Minor allele frequency- T:0.01WA 118
    rs1829220431,2
    C--6524490(+) GGTCCA/CACAGT 11 G W mis1 int10--------
    rs118004621,2,,4
    C,F,A,H--6524501(+) CAGTAT/CCTCTG 11 /D /G mis1 int124Minor allele frequency- C:0.12NS EA NA CSA WA EU 8137
    rs1996348921,2
    C--6524519(+) CTGCAA/GTCCAG 6 -- int10--------
    rs455586321,2
    C--6524596(-) CCACCC/TAGGGC 6 -- int11Minor allele frequency- T:0.01NS 162
    rs2016389461,2
    --6524600(+) TGGGTA/GGGGGT 6 -- int10--------
    rs773883721,2
    C--6524639(+) CAGGGC/GCCCGC 11 P A mis1 int10--------
    rs351372931,2
    C,F--6524649(+) CAGTCT/CAGGCA 11 /L syn1 int18Minor allele frequency- C:0.03NA NS CSA WA EU 5422

    HapMap Linkage Disequilibrium report for TNFRSF25 (6521211 - 6526255 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TNFRSF25 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508836CNV Insertion20534489
    nsv470691CNV Loss18288195
    nsv871698CNV Loss21882294
    nsv462061CNV Loss19166990
    nsv871719CNV Loss21882294
    nsv870465CNV Loss21882294
    dgv127n71CNV Loss21882294
    dgv119n71CNV Loss21882294
    dgv125n71CNV Loss21882294
    nsv831536CNV Loss17160897

    Human Gene Mutation Database (HGMD): TNFRSF25
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFRSF25
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFRSF25

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603366    OMIM disorders: --

    18 diseases for TNFRSF25:    
    About MalaCards
    immunoglobulin alpha deficiency    hypersensitivity reaction type ii disease    type 1 diabetes mellitus    addison's disease
    type 1 diabetes    polycythemia    hodgkin's lymphoma    non-hodgkin lymphoma
    diabetes mellitus    multiple myeloma    myeloma    neuroblastoma
    rheumatoid arthritis    arthritis    endotheliitis    leukemia
    prostatitis    breast cancer


    TNFRSF25 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TNFRSF25 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 48.4 7 18824582 (1), 11216825 (1), 14965271 (1), 11455969 (1) (see all 7)
    tumors 31.3 7 18824582 (1), 11216825 (1), 14965271 (1), 15694416 (1) (see all 7)

    Genetic Association Database (GAD): TNFRSF25
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF25 (6 documents)

    Export disorders for TNFRSF25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFRSF25 gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with TNFRSF25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). (PubMed id 9052839)1, 2, 3 Bodmer J.-L.... Tschopp J. (Immunity 1997)
    2. A death-domain-containing receptor that mediates apoptosis. (PubMed id 8934525)1, 2, 3 Kitson J.... Farrow S.N. (Nature 1996)
    3. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. (PubMed id 8875942)1, 2, 9 Chinnaiyan A.M.... Dixit V.M. (Science 1996)
    4. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    6. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    7. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PubMed id 15301860)1, 4 Cho S.M....Lee J.K. (Hum. Immunol. 2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    9. Relationship of large multifunctional proteasome 7 gene polymorphism with susceptibility to type 1 diabetes mellitus and DR3 gene. (PubMed id 11793848)1, 4 Ding H....Yang G. (Chin. Med. J. 2001)
    10. The relationship of lmp2 and DR3 genes with susceptibility to type I diabetes mellitus in south China Han population. (PubMed id 11819535)1, 4 Ding H.L....Yan T. (World J. Gastroenterol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8718 HGNC: 11910 AceView: TNFRSF25andKIAA0720 Ensembl:ENSG00000215788 euGenes: HUgn8718
    ECgene: TNFRSF25 Kegg: 8718 H-InvDB: TNFRSF25

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNFRSF25 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF25 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf25/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFRSF25 gene:
    Search GeneIP for patents involving TNFRSF25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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