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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TNFRSF25 Gene

protein-coding GIFtS: 61
GCID: GC01M006521

Tumor Necrosis Factor Receptor Superfamily, Member 25

(Previous names: tumor necrosis factor receptor superfamily, member 12 (translocating...)
(Previous symbol: TNFRSF12)

18 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 25¹ ²		TRAMP²
TNFRSF12¹ ² ³ ⁵		WSL-1²
DR3² ³ ⁵		WSL-LR²
LARD² ³ ⁵		Apoptosis Inducing Receptor²
Tumor Necrosis Factor Receptor Superfamily, Member 12 (Translocating Chain-Association Membrane Protein)¹ ²		Death Domain Receptor 3 Soluble Form²
Apoptosis-Inducing Receptor AIR² ³		Death Receptor Beta²
Apoptosis-Mediating Receptor DR3² ³		Tumor Necrosis Factor Receptor Superfamily Member 25²
Apoptosis-Mediating Receptor TRAMP² ³		APO3³
Lymphocyte-Associated Receptor Of Death² ³		Apo-3³
Protein WSL-1² ³		WSL³
DDR3² ³		WSL1³
APO-3²		Death Receptor 3³
TR3²		Protein WSL³

External Ids:	HGNC: 11910¹	Entrez Gene: 8718²	Ensembl: ENSG00000215788⁷	OMIM: 603366⁵	UniProtKB: Q93038³

Export aliases for TNFRSF25 gene to outside databases

Previous GC identifers: GC01M006330 GC01M006117 GC01M006230 GC01M006455 GC01M005668

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF25 Gene:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed

preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte

homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The

signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout

studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple

alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of

which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a

programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and

is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. (provided by

RefSeq, Jul 2008)

GeneCards Summary for TNFRSF25 Gene:

TNFRSF25 (tumor necrosis factor receptor superfamily, member 25) is a protein-coding gene. Diseases associated with TNFRSF25 include immunoglobulin alpha deficiency, and hypersensitivity reaction type ii disease, and among its related super-pathways are TNF Signaling and Apoptosis Signaling Pathways. GO annotations related to this gene include tumor necrosis factor-activated receptor activity and receptor activity. An important paralog of this gene is TNFRSF1A.

UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038

Function: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of

NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis

Gene Wiki entry for TNFRSF25 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NT_021937.19 NC_018912.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNFRSF25 gene promoter:
p53 AP-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNFRSF25 promoter sequence

Search SABiosciences Chromatin IP Primers for TNFRSF25

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF25

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2 Ensembl cytogenetic band: 1p36.31 HGNC cytogenetic band: 1p36.2

TNFRSF25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF25 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M006521: view genomic region (about GC identifiers)

Start:	6,521,211 bp from pter	End:	6,526,255 bp from pter
Size:	5,045 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 25 precursor

Size: 417 amino acids; 45385 Da

Subunit: Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two

distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 9: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 11: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 3: Secreted

Subcellular location: Isoform 4: Secreted

Subcellular location: Isoform 5: Secreted

Subcellular location: Isoform 6: Secreted

Subcellular location: Isoform 7: Secreted

Subcellular location: Isoform 8: Secreted

Subcellular location: Isoform 10: Secreted

Subcellular location: Isoform 12: Secreted

Secondary accessions: B1ALX2 B1ALX3 B7ZLL7 O00275 O00276 O00277 O00278 O00279 O00280 O14865

O14866 P78507 P78515 Q17RU4 Q92983 Q93036 Q93037 Q99722 Q99830 Q99831 Q9BY86 Q9UME0 Q9UME1

Q9UME5

Alternative splicing: 12 isoforms: Q93038-1 Q93038-2 Q93038-3 Q93038-4 Q93038-5 Q93038-6 Q93038-7 Q93038-8

Q93038-9 Q93038-10 Q93038-11 Q93038-12 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for TNFRSF25: NX_Q93038

Explore proteomics data for TNFRSF25 at MOPED

Post-translational modifications:

UniProtKB: Glycosylated (Probable)

View neXtProt modification sites for NX_Q93038

TNFRSF25 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (6 alternative transcripts):

NP_001034753.1 NP_003781.1 NP_683866.1 NP_683867.1 NP_683868.1 NP_683871.1

ENSEMBL proteins:

ENSP00000431554 ENSP00000434129 ENSP00000367013 ENSP00000349341 ENSP00000337713

ENSP00000404274 ENSP00000326762 ENSP00000314451 ENSP00000423121 ENSP00000421976

ENSP00000424071 ENSP00000465381

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Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005829	cytosol	NAS	9114039
GO:0005886	plasma membrane	IDA	11911831
GO:0005887	integral to plasma membrane	TAS	9052839

TNFRSF25 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

TNFRSF: Tumor necrosis factor receptor superfamily

IUPHAR Guide to PHARMACOLOGY protein family classification: death receptor 3

Tumour necrosis factor (TNF) receptor family

4 InterPro protein domains:

IPR001368 TNFR/NGFR_Cys_rich_reg

IPR011029 DEATH-like_dom

IPR000488 Death_domain

IPR022329 TNFR_25

Graphical View of Domain Structure for InterPro Entry Q93038

ProtoNet protein and cluster: Q93038

2 Blocks protein domains:

IPB000488 Death domain

IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038

Similarity: Contains 1 death domain

Similarity: Contains 4 TNFR-Cys repeats

TNFRSF25 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TNR25_HUMAN, Q93038

Function: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of

NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	NAS	9114039
GO:0005031	tumor necrosis factor-activated receptor activity	TAS	9052839
GO:0005515	protein binding	--	--

TNFRSF25 for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tnfrsf25):

cellular

hematopoietic system

immune system

TNFRSF25 for phenotypes About GeneDecksing

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TNFRSF25 About (see all 6)

See pathways by source

SuperPath

Contained pathways About

TNF Signaling

	TNF Signaling	0.50			TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions	0.49
	Death Receptor Signaling	0.50			NF-kB (NFkB) Pathway	0.46

Apoptosis and survival Apoptotic TNF-family pathways

Apoptosis and survival Apoptotic TNF-family pathways

0.35

Apoptosis Signaling Pathways

0.35

Apoptosis Modulation and Signaling

Apoptosis

0.38

Apoptosis Modulation and Signaling

0.38

Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

0.46

PEDF Induced Signaling

Cytokine-cytokine receptor interaction

0.43

Pathways by source See SuperPaths
Show all pathways

2 EMD Millipore Pathways for TNFRSF25

	Apoptosis and survival Apoptotic TNF-family pathways
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

2 R&D Systems Pathways for TNFRSF25

	TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
	Apoptosis Signaling Pathways

1 Cell Signaling Technology (CST) Pathway for TNFRSF25

Apoptosis and Autophagy

2 GeneGo (Thomson Reuters) Pathways for TNFRSF25

	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
	Apoptosis and survival Apoptotic TNF-family pathways

2 BioSystems Pathways for TNFRSF25

	Apoptosis
	Apoptosis Modulation and Signaling

3 Sino Biological Pathways for TNFRSF25

	TNF Signaling
	Death Receptor Signaling
	NF-kB (NFkB) Pathway

1 Kegg Pathway (Kegg details for TNFRSF25):

Cytokine-cytokine receptor interaction

TNFRSF25 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TNFRSF25

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/20 Interacting proteins for TNFRSF25 (Q93038³ ENSP00000367013⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRADD	Q15628³, ENSP00000341268⁴	I2D: score=3 STRING: ENSP00000341268
BAG4	O95429³, ENSP00000287322⁴	I2D: score=2 STRING: ENSP00000287322
MAPK1	P28482³, ENSP00000215832⁴	I2D: score=2 STRING: ENSP00000215832
NOL3	O60936³, ENSP00000268605⁴	I2D: score=1 STRING: ENSP00000268605
TNFSF15	O95150³, ENSP00000363157⁴	I2D: score=2 STRING: ENSP00000363157

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	NAS	9114039
GO:0007165	signal transduction	TAS	8875942
GO:0007166	cell surface receptor signaling pathway	TAS	9052839
GO:0033209	tumor necrosis factor-mediated signaling pathway	TAS	9052839
GO:0042981	regulation of apoptotic process	NAS	9114039

TNFRSF25 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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1 IUPHAR Ligand for TNFRSF25 (death receptor 3) About this table

Ligand	Type	Action	Affinity	Pubmed IDs
TL1A	None	None		--

Search CenterWatch for drugs/clinical trials and news about TNFRSF25 / TNR25

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNFRSF25 gene (9 alternative transcripts):

NM_001039664.1 NM_003790.2 NM_148965.1 NM_148966.1 NM_148967.1 NM_148970.1 NM_148968.1 NM_148969.1

NM_148974.1

Unigene Cluster for TNFRSF25:

Tumor necrosis factor receptor superfamily, member 25

Hs.462529 [show with all ESTs]

Unigene Representative Sequence: Y09392

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000473343 ENST00000513135 ENST00000485036 ENST00000480393 ENST00000377782(uc001anh.3)

ENST00000356876(uc001ana.3 uc001anb.3 uc001anc.3 uc001and.3 uc009vlz.3 uc001ane.3 uc001anf.3 uc001ang.3)

ENST00000351959 ENST00000414040 ENST00000351748 ENST00000348333 ENST00000502588

ENST00000502730 ENST00000510563 ENST00000453260 ENST00000475730 ENST00000469691

ENST00000481401 ENST00000461703

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Additional mRNA sequence:

AB308321.1 AF026070.1 AY358309.1 BC117189.1 BC143886.1 U72763.1 U74611.1 U75380.1

U75381.1 U78029.1 U83597.1 U83598.1 U94501.1 U94502.1 U94508.1 U94509.1

U94510.1 U94511.1 U94512.1 Y09392.1

14 DOTS entries:

DT.92431005 DT.86847342 DT.100790315 DT.99933149 DT.97763290 DT.100790318 DT.86847340 DT.121426091

DT.121426124 DT.75112427 DT.95250774 DT.101984073 DT.92005786 DT.99948401

24/180 AceView cDNA sequences (see all 180):

BM695193 AW050746 NM_148973 U94507 BM770798 NM_148974 BM792178 AB018263

BE670189 BM783979 AI275938 U94504 NM_148967 U94505 U74611 NM_148965

CR619991 BF063258 AK024676 NM_020631 U94510 U94509 U94503 BE563566

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNFRSF25 expression in normal human tissues (normalized intensities) TNFRSF25 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGGCTGGACG

About this image

TNFRSF25 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/5 selected tissues (see all 5) fully expand


Blood (Cardiovascular System) fully expand to see all 9 entries
T Helper Cells Thymus
Peripheral blood Pan-T Cells
t cells

Brain (Nervous System) fully expand to see all 3 entries
Cerebellum
cerebellum

Thymus (Hematopoietic System) fully expand to see all 3 entries
T Helper Cells Thymus

Umbilical Cord (Extraembryonic Tissues)
Cord Blood Pan-T Cells

Spleen (Hematopoietic System)

See TNFRSF25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFRSF25

SOURCE GeneReport for Unigene cluster: Hs.462529

UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038

Tissue specificity: Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such

as thymus, colon, intestine, and spleen. Also found in the prostate

SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF25:

TNF Ligands & Receptors in human mouse rat

Neurotoxicity in human mouse rat

Apoptosis 384HT in human mouse rat

Apoptosis in human mouse rat

Necrosis in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF25 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tnfrsf25^{1 , 5}	tumor necrosis factor receptor superfamily, member more^{1, 5}	75.64(n)¹ 69.12(a)¹		4 (82.89 cM)⁵ 85030¹ NM_033042.3¹ NP_149031.2¹ 152115934⁵
chicken (Gallus gallus)	Aves	TNFRSF25¹	tumor necrosis factor receptor superfamily, member more	52.34(n) 41.01(a)		425564 XM_423315.3 XP_423315.3
zebrafish (Danio rerio)	Actinopterygii	TNFRSF25⁶	tumor necrosis factor receptor superfamily, member...	17(a)	1 ↔ 1	23(21060592-21068774)

ENSEMBL Gene Tree for TNFRSF25 (if available)
TreeFam Gene Tree for TNFRSF25 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TNFRSF25 gene

TNFRSF1A²

TNFRSF25 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140642935^1,2		--	6524252(+)	`TAAGGC/TGGATC`	6	--	int¹ ut3¹		0	--	--	--	--
rs45599832^1,2	C,F	--	6524367(-)	`TGGGGC/AAGGTG`	6	--	int¹ ut3¹		2		NS WA	284
rs115539300^1,2	C	--	6524415(+)	`CCATCC/TCACGA`	6	--	int¹ ut3¹		1		WA	118
rs182922043^1,2	C	--	6524490(+)	`GGTCCA/CACAGT`	11	G W	mis¹ int¹		0	--	--	--	--
rs11800462^1,2,4	C,F,A,H	--	6524501(+)	`CAGTAT/CCTCTG`	11	/D /G	mis¹ int¹		24		NS EA NA CSA WA EU	8137
rs199634892^1,2	C	--	6524519(+)	`CTGCAA/GTCCAG`	6	--	int¹		0	--	--	--	--
rs45558632^1,2	C	--	6524596(-)	`CCACCC/TAGGGC`	6	--	int¹		1		NS	162
rs201638946^1,2		--	6524600(+)	`TGGGTA/GGGGGT`	6	--	int¹		0	--	--	--	--
rs77388372^1,2	C	--	6524639(+)	`CAGGGC/GCCCGC`	11	P A	mis¹ int¹		0	--	--	--	--
rs35137293^1,2	C,F	--	6524649(+)	`CAGTCT/CAGGCA`	11	/L	syn¹ int¹		8		NA NS CSA WA EU	5422

HapMap Linkage Disequilibrium report for TNFRSF25 (6521211 - 6526255 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/19 variations for TNFRSF25 (see all 19): About this table

Variant ID	Type	Subtype	PubMed ID
nsv508836	CNV	Insertion	20534489
nsv470691	CNV	Loss	18288195
nsv871698	CNV	Loss	21882294
nsv462061	CNV	Loss	19166990
nsv871719	CNV	Loss	21882294
nsv870465	CNV	Loss	21882294
dgv127n71	CNV	Loss	21882294
dgv119n71	CNV	Loss	21882294
dgv125n71	CNV	Loss	21882294
nsv831536	CNV	Loss	17160897

Human Gene Mutation Database (HGMD): TNFRSF25

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 603366 OMIM disorders: --

18 diseases for TNFRSF25: About MalaCards

immunoglobulin alpha deficiency hypersensitivity reaction type ii disease type 1 diabetes mellitus addison's disease

type 1 diabetes polycythemia multiple myeloma non-hodgkin lymphoma

hodgkin's lymphoma myeloma diabetes mellitus neuroblastoma

rheumatoid arthritis endotheliitis arthritis colon cancer

leukemia prostatitis

TNFRSF25 for disorders About GeneDecksing

2 Novoseek inferred disease relationships for TNFRSF25 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	48.4	7	18824582 (1), 11216825 (1), 14965271 (1), 11455969 (1) (see all 7)
tumors	31.3	7	18824582 (1), 11216825 (1), 14965271 (1), 15694416 (1) (see all 7)

Genetic Association Database (GAD): TNFRSF25
Human Genome Epidemiology (HuGE) Navigator: TNFRSF25 (6 documents)

Export disorders for TNFRSF25 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TNFRSF25 gene, integrated from 9 sources (see all 71):
(articles sorted by number of sources associating them with TNFRSF25)

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world of online information

TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). (PubMed id 9052839)^{1, 2, 3} Bodmer J.-L.... Tschopp J. (1997)
A death-domain-containing receptor that mediates apoptosis. (PubMed id 8934525)^{1, 2, 3} Kitson J....Farrow S.N. (1996)
Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. (PubMed id 8875942)^{1, 2, 9} Chinnaiyan A.M.... Dixit V.M. (1996)
Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)^{1, 4} Lee K.M....Lan Q. (2010)
Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)^{1, 4} Hosgood H.D....Lan Q. (2009)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{1, 2} Hillman R.T.... Brenner S.E. (2004)
Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PubMed id 15301860)^{1, 4} Cho S.M....Lee J.K. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Relationship of large multifunctional proteasome 7 gene polymorphism with susceptibility to type 1 diabetes mellitus and DR3 gene. (PubMed id 11793848)^{1, 4} Ding H....Yang G. (2001)
The relationship of lmp2 and DR3 genes with susceptibility to type I diabetes mellitus in south China Han population. (PubMed id 11819535)^{1, 4} Ding H.L....Yan T. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8718	HGNC: 11910	AceView: TNFRSF25andKIAA0720	Ensembl:ENSG00000215788	euGenes: HUgn8718
ECgene: TNFRSF25	Kegg: 8718	H-InvDB: TNFRSF25

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TNFRSF25	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFRSF25	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/tnfrsf25/

Intellectual Property for TNFRSF25 gene
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Patent Information for TNFRSF25 gene:
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GeneCards and IP:
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TNFRSF25 Gene

Tumor Necrosis Factor Receptor Superfamily, Member 25

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TNFRSF25 (Gene Symbol)
Tumor Necrosis Factor Receptor Superfamily, Member 25
TNFRSF12
DR3
LARD
Tumor Necrosis Factor Receptor Superfamily, Member 12 (Translocating Chain-Association Membrane Protein)
Apoptosis-Inducing Receptor AIR
Apoptosis-Mediating Receptor DR3
Apoptosis-Mediating Receptor TRAMP
Lymphocyte-Associated Receptor Of Death
Protein WSL-1
DDR3
APO-3
TR3
TRAMP
WSL-1
WSL-LR
Apoptosis Inducing Receptor
Death Domain Receptor 3 Soluble Form
Death Receptor Beta
Tumor Necrosis Factor Receptor Superfamily Member 25
APO3
Apo-3
WSL
WSL1
Death Receptor 3
Protein WSL

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TNFRSF25 Gene

Tumor Necrosis Factor Receptor Superfamily, Member 25

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