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Aliases for TNFRSF25 Gene

Aliases for TNFRSF25 Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 25 2 3
  • TNFRSF12 3 4 6
  • LARD 3 4 6
  • DR3 3 4 6
  • Tumor Necrosis Factor Receptor Superfamily, Member 12 (Translocating Chain-Association Membrane Protein) 2 3
  • Lymphocyte-Associated Receptor Of Death 3 4
  • Apoptosis-Mediating Receptor TRAMP 3 4
  • Apoptosis-Mediating Receptor DR3 3 4
  • Apoptosis-Inducing Receptor AIR 3 4
  • Protein WSL-1 3 4
  • APO-3 3 4
  • DDR3 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 25 3
  • Death Domain Receptor 3 Soluble Form 3
  • Apoptosis Inducing Receptor 3
  • Death Receptor Beta 3
  • Death Receptor 3 4
  • Protein WSL 4
  • WSL-LR 3
  • TRAMP 3
  • WSL-1 3
  • APO3 4
  • WSL1 4
  • TR3 3
  • WSL 4

External Ids for TNFRSF25 Gene

Previous HGNC Symbols for TNFRSF25 Gene

  • TNFRSF12

Previous GeneCards Identifiers for TNFRSF25 Gene

  • GC01M006330
  • GC01M006117
  • GC01M006230
  • GC01M006455
  • GC01M005668

Summaries for TNFRSF25 Gene

Entrez Gene Summary for TNFRSF25 Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF25 Gene

TNFRSF25 (Tumor Necrosis Factor Receptor Superfamily, Member 25) is a Protein Coding gene. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include receptor activity and tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF1A.

UniProtKB/Swiss-Prot for TNFRSF25 Gene

  • Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis

Gene Wiki entry for TNFRSF25 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF25 Gene

Genomics for TNFRSF25 Gene

Regulatory Elements for TNFRSF25 Gene

Transcription factor binding sites by QIAGEN in the TNFRSF25 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNFRSF25 Gene

6,461,151 bp from pter
6,466,195 bp from pter
5,045 bases
Minus strand

Genomic View for TNFRSF25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF25 Gene

Proteins for TNFRSF25 Gene

  • Protein details for TNFRSF25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 25
    Protein Accession:
    Secondary Accessions:
    • B1ALX2
    • B1ALX3
    • B7ZLL7
    • O00275
    • O00276
    • O00277
    • O00278
    • O00279
    • O00280
    • O14865
    • O14866
    • P78507
    • P78515
    • Q17RU4
    • Q92983
    • Q93036
    • Q93037
    • Q99722
    • Q99830
    • Q99831
    • Q9BY86
    • Q9UME0
    • Q9UME1
    • Q9UME5

    Protein attributes for TNFRSF25 Gene

    417 amino acids
    Molecular mass:
    45385 Da
    Quaternary structure:
    • Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.

    Alternative splice isoforms for TNFRSF25 Gene

neXtProt entry for TNFRSF25 Gene

Proteomics data for TNFRSF25 Gene at MOPED

Post-translational modifications for TNFRSF25 Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF25 (DR3/TNFRSF25)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF25 (TNFRSF25)

Protein Products

  • Enzo Life Sciences proteins for TNFRSF25
  • Cloud-Clone Corp. Proteins for TNFRSF25

No data available for DME Specific Peptides for TNFRSF25 Gene

Domains for TNFRSF25 Gene

Gene Families for TNFRSF25 Gene

  • TNFRSF :Tumor necrosis factor receptor superfamily

Graphical View of Domain Structure for InterPro Entry



  • Q93038
  • Contains 1 death domain.
  • Contains 4 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF25: view

Function for TNFRSF25 Gene

Molecular function for TNFRSF25 Gene

UniProtKB/Swiss-Prot Function: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis

Gene Ontology (GO) - Molecular Function for TNFRSF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity NAS 9114039
GO:0005031 tumor necrosis factor-activated receptor activity TAS 9052839
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TNFRSF25: view

Phenotypes for TNFRSF25 Gene

genes like me logo Genes that share phenotypes with TNFRSF25: view

Animal Model Products

CRISPR Products

miRNA for TNFRSF25 Gene

miRTarBase miRNAs that target TNFRSF25

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TNFRSF25 Gene

Localization for TNFRSF25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF25 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 9: Cell membrane; Single-pass type I membrane protein.
Isoform 11: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.
Isoform 4: Secreted.
Isoform 5: Secreted.
Isoform 6: Secreted.
Isoform 7: Secreted.
Isoform 8: Secreted.
Isoform 10: Secreted.
Isoform 12: Secreted.

Subcellular locations from

Jensen Localization Image for TNFRSF25 Gene COMPARTMENTS Subcellular localization image for TNFRSF25 gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 5
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TNFRSF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005829 cytosol NAS 9114039
GO:0005886 plasma membrane IDA 11911831
GO:0005887 integral component of plasma membrane TAS 9052839
genes like me logo Genes that share ontologies with TNFRSF25: view

Pathways for TNFRSF25 Gene

genes like me logo Genes that share pathways with TNFRSF25: view

Pathways by source for TNFRSF25 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for TNFRSF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process NAS 9114039
GO:0007165 signal transduction TAS 8875942
GO:0007166 cell surface receptor signaling pathway TAS 9052839
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS 9052839
GO:0042981 regulation of apoptotic process NAS 9114039
genes like me logo Genes that share ontologies with TNFRSF25: view

Compounds for TNFRSF25 Gene

(1) IUPHAR Ligand for TNFRSF25 Gene

Ligand Type Action Affinity Pubmed IDs
TL1A None None
genes like me logo Genes that share compounds with TNFRSF25: view

Transcripts for TNFRSF25 Gene

Unigene Clusters for TNFRSF25 Gene

Tumor necrosis factor receptor superfamily, member 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF25

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF25 Gene

No ASD Table

Relevant External Links for TNFRSF25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF25 Gene

mRNA expression in normal human tissues for TNFRSF25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF25 Gene

This gene is overexpressed in Brain - Cerebellum (9.3) and Brain - Cerebellar Hemisphere (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNFRSF25 Gene

SOURCE GeneReport for Unigene cluster for TNFRSF25 Gene Hs.462529

mRNA Expression by UniProt/SwissProt for TNFRSF25 Gene

Tissue specificity: Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate
genes like me logo Genes that share expressions with TNFRSF25: view

In Situ Assay Products

Orthologs for TNFRSF25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFRSF25 35
  • 96.25 (n)
  • 95.31 (a)
  • 95 (a)
(Bos Taurus)
Mammalia TNFRSF25 35
  • 78.35 (n)
  • 72.16 (a)
  • 69 (a)
(Canis familiaris)
Mammalia TNFRSF25 35
  • 80.53 (n)
  • 73.9 (a)
  • 69 (a)
(Mus musculus)
Mammalia Tnfrsf25 35
  • 75.7 (n)
  • 69.16 (a)
Tnfrsf25 16
Tnfrsf25 36
  • 59 (a)
(Monodelphis domestica)
Mammalia TNFRSF25 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia TNFRSF25 36
  • 46 (a)
(Rattus norvegicus)
Mammalia Tnfrsf25 35
  • 73.67 (n)
  • 65.75 (a)
(Gallus gallus)
Aves TNFRSF25 35
  • 54.17 (n)
  • 42.9 (a)
  • 30 (a)
(Danio rerio)
Actinopterygii TNFRSF25 36
  • 22 (a)
Species with no ortholog for TNFRSF25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF25 Gene

Gene Tree for TNFRSF25 (if available)
Gene Tree for TNFRSF25 (if available)

Paralogs for TNFRSF25 Gene

Paralogs for TNFRSF25 Gene

genes like me logo Genes that share paralogs with TNFRSF25: view

Variants for TNFRSF25 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF25 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1059333 - 6,461,546(-) CAAGC(A/G)CTGGC missense, reference
rs1059334 -- 6,461,581(-) ATCGG(C/T)CGCTT reference, synonymous-codon
rs1064590 - 6,461,579(-) CGGCC(G/T)CTTCC reference, missense
rs2274510 -- 6,465,275(+) CCCCC(A/G)ACCTG intron-variant
rs2986755 -- 6,463,765(-) CTGTA(A/G)CTATT downstream-variant-500B, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF25 Gene

Variant ID Type Subtype PubMed ID
nsv871698 CNV Loss 21882294
dgv119n71 CNV Loss 21882294
dgv122n71 CNV Loss 21882294
dgv125n71 CNV Loss 21882294
dgv2n27 CNV Loss 19166990
nsv508836 CNV Insertion 20534489
esv25412 CNV Gain+Loss 19812545
nsv871719 CNV Loss 21882294
nsv7880 CNV Gain+Loss 18304495
nsv831536 CNV Loss 17160897
dgv9n67 CNV Gain 20364138
nsv470690 CNV Gain 18288195
nsv870465 CNV Loss 21882294
dgv126n71 CNV Loss 21882294
dgv127n71 CNV Loss 21882294
nsv470691 CNV Loss 18288195
dgv128n71 CNV Loss 21882294
nsv870716 CNV Loss 21882294
nsv462061 CNV Loss 19166990

Relevant External Links for TNFRSF25 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF25 Gene

Disorders for TNFRSF25 Gene

(2) Novoseek inferred disease relationships for TNFRSF25 Gene

Disease -log(P) Hits PubMed IDs
necrosis 48.4 7
tumors 31.3 7

Relevant External Links for TNFRSF25

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TNFRSF25: view

No data available for UniProtKB/Swiss-Prot for TNFRSF25 Gene

Publications for TNFRSF25 Gene

  1. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. (PMID: 8875942) Chinnaiyan A.M. … Dixit V.M. (Science 1996) 3 4 23
  2. A death-domain-containing receptor that mediates apoptosis. (PMID: 8934525) Kitson J. … Farrow S.N. (Nature 1996) 2 3 4
  3. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). (PMID: 9052839) Bodmer J.-L. … Tschopp J. (Immunity 1997) 2 3 4
  4. LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing. (PMID: 9114039) Screaton G.R. … Bell J.I. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 4
  5. A new death receptor 3 isoform: expression in human lymphoid cell lines and non-Hodgkin's lymphomas. (PMID: 9446802) Warzocha K. … Salles G. (Biochem. Biophys. Res. Commun. 1998) 3 4

Products for TNFRSF25 Gene

Sources for TNFRSF25 Gene

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