Aliases for TNFRSF25 Gene
Aliases for TNFRSF25 Gene
- TNF Receptor Superfamily Member 25 2 3 5
- Tumor Necrosis Factor Receptor Superfamily, Member 12 (Translocating Chain-Association Membrane Protein) 2 3
- Lymphocyte-Associated Receptor Of Death 3 4
- Apoptosis-Mediating Receptor TRAMP 3 4
- Apoptosis-Mediating Receptor DR3 3 4
- Apoptosis-Inducing Receptor AIR 3 4
- Protein WSL-1 3 4
- TNFRSF12 3 4
- APO-3 3 4
- DDR3 3 4
- LARD 3 4
- DR3 3 4
- Tumor Necrosis Factor Receptor Superfamily, Member 25 2
- Tumor Necrosis Factor Receptor Superfamily Member 25 3
External Ids for TNFRSF25 Gene
- HGNC: 11910
- Entrez Gene: 8718
- Ensembl: ENSG00000215788
- OMIM: 603366
- UniProtKB: Q93038
Previous HGNC Symbols for TNFRSF25 Gene
- TNFRSF12
Previous GeneCards Identifiers for TNFRSF25 Gene
- GC01M006330
- GC01M006117
- GC01M006230
- GC01M006455
- GC01M005668
Summaries for TNFRSF25 Gene
-
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF25 Gene
TNFRSF25 (TNF Receptor Superfamily Member 25) is a Protein Coding gene. Diseases associated with TNFRSF25 include Punctate Epithelial Keratoconjunctivitis and Juvenile Dermatitis Herpetiformis. Among its related pathways are TRAF Pathway and PEDF Induced Signaling. GO annotations related to this gene include receptor activity and tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF1A.
UniProtKB/Swiss-Prot for TNFRSF25 Gene
-
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF25 Gene
Genomics for TNFRSF25 Gene
Regulatory Elements for TNFRSF25 Gene
Enhancers for TNFRSF25 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TNFRSF25 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TNFRSF25 gene promoter:
Regulatory Element Products
Genomic Location for TNFRSF25 Gene
- Chromosome:
- 1
- Start:
- 6,461,151 bp from pter
- End:
- 6,466,195 bp from pter
- Size:
- 5,045 bases
- Orientation:
- Minus strand
Genomic View for TNFRSF25 Gene
Genes around TNFRSF25 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.31 by Ensembl
- 1p36.31 by Entrez Gene
- 1p36.31 by HGNC
TNFRSF25 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TNFRSF25 Gene
Proteins for TNFRSF25 Gene
-
Protein details for TNFRSF25 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q93038-TNR25_HUMAN
- Recommended name:
- Tumor necrosis factor receptor superfamily member 25
- Protein Accession:
- Q93038
- B1ALX2
- B1ALX3
- B7ZLL7
- O00275
- O00276
- O00277
- O00278
- O00279
- O00280
- O14865
- O14866
- P78507
- P78515
- Q17RU4
- Q92983
- Q93036
- Q93037
- Q99722
- Q99830
- Q99831
- Q9BY86
- Q9UME0
- Q9UME1
- Q9UME5
Protein attributes for TNFRSF25 Gene
- Size:
- 417 amino acids
- Molecular mass:
- 45385 Da
- Quaternary structure:
-
- Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.
Protein Expression for TNFRSF25 Gene
Post-translational modifications for TNFRSF25 Gene
- Glycosylated.
- Glycosylation at Asn67 and Asn106
Other Protein References for TNFRSF25 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TNFRSF25 (DR3/TNFRSF25)
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-
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-
Abcam antibodies for TNFRSF25
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- antibodies-online Antibodies for TNFRSF25: See all 189
- GeneTex TNFRSF25 antibody for TNFRSF25
-
Custom Antibody ServicesProSci Antibodies for TNFRSF25
-
Santa Cruz Biotechnology (SCBT) Antibodies for TNFRSF25
Protein Products
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-
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- antibodies-online Proteins for TNFRSF25: See all 4
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-
ProSci Proteins for TNFRSF25
-
Abcam proteins for TNFRSF25
Assay Products
- R&D Systems Luminex Assays, ELISAs, and other biochemical assays for TNFRSF25 (DR3/TNFRSF25)
- antibodies-online Kits for TNFRSF25: See all 1
No data available for DME Specific Peptides for TNFRSF25 Gene
Domains & Families for TNFRSF25 Gene
Gene Families for TNFRSF25 Gene
- HGNC:
- IUPHAR :
Protein Domains for TNFRSF25 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TNFRSF25 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TNFRSF25 Gene
Function for TNFRSF25 Gene
Molecular function for TNFRSF25 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004872 | receptor activity | NAS | 9114039 |
| GO:0005031 | tumor necrosis factor-activated receptor activity | TAS | 9052839 |
Phenotypes for TNFRSF25 Gene
- MGI mutant phenotypes for TNFRSF25:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for TNFRSF25:
Animal Model Products
-
Taconic Biosciences Mouse Models for TNFRSF25
- Cyagen custom Knockout/knockin (KOKI) mouse models for TNFRSF25
-
- Search ViGene Biosciences for TNFRSF25
CRISPR Products
-
OriGene CRISPR knockouts for TNFRSF25
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNFRSF25
- GenScript: Design CRISPR guide RNA sequences for TNFRSF25
miRNA for TNFRSF25 Gene
- miRTarBase miRNAs that target TNFRSF25
miRNA Products
- Search ViGene Biosciences for TNFRSF25
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for TNFRSF25
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Clone Products
-
OriGene ORF clones in human for TNFRSF25
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for TNFRSF25 (DR3/TNFRSF25)
Cell Line Products
-
Horizon Cell Lines for TNFRSF25
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF25 Gene
Localization for TNFRSF25 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF25 Gene
- Isoform 1: Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Cell membrane; Single-pass type I membrane protein.
- Isoform 9: Cell membrane; Single-pass type I membrane protein.
- Isoform 11: Cell membrane; Single-pass type I membrane protein.
- Isoform 3: Secreted.
- Isoform 4: Secreted.
- Isoform 5: Secreted.
- Isoform 6: Secreted.
- Isoform 7: Secreted.
- Isoform 8: Secreted.
- Isoform 10: Secreted.
- Isoform 12: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| mitochondrion | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005829 | cytosol | NAS | 9114039 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 9052839 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for TNFRSF25 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis Modulation and Signaling |
.41
|
|
| 2 | PEDF Induced Signaling |
.47
|
|
| 3 | Akt Signaling |
.60
.60
|
|
| 4 | TNFR1 Pathway |
.87
.87
|
|
| 5 | TGF-Beta Pathway |
.60
.57
|
.51
|
Pathways by source for TNFRSF25 Gene
1 Sino Biological pathway for TNFRSF25 Gene
2 Cell Signaling Technology pathways for TNFRSF25 Gene
2 BioSystems pathways for TNFRSF25 Gene
4 Reactome pathways for TNFRSF25 Gene
1 KEGG pathway for TNFRSF25 Gene
2 GeneGo (Thomson Reuters) pathways for TNFRSF25 Gene
3 R&D Systems pathways for TNFRSF25 Gene
15 Qiagen pathways for TNFRSF25 Gene
Interacting Proteins for TNFRSF25 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | TAS,NAS | 9114039 |
| GO:0006954 | inflammatory response | IBA | -- |
| GO:0006955 | immune response | IBA | -- |
| GO:0007165 | signal transduction | TAS | 8875942 |
| GO:0007166 | cell surface receptor signaling pathway | TAS | 9052839 |
Drugs & Compounds for TNFRSF25 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| TL1A | Pharma | 0 |
Transcripts for TNFRSF25 Gene
mRNA/cDNA for TNFRSF25 Gene
- (9) REFSEQ mRNAs :
- (20) Additional mRNA sequences :
- (180) Selected AceView cDNA sequences:
- (20) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TNFRSF25 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TNFRSF25
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNFRSF25
- GenScript: Design CRISPR guide RNA sequences for TNFRSF25
miRNA Products
- Search ViGene Biosciences for TNFRSF25
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for TNFRSF25
- Browse OriGene Inhibitory RNA Products For TNFRSF25
Clone Products
-
OriGene ORF clones in human for TNFRSF25
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TNFRSF25
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TNFRSF25
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TNFRSF25
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for TNFRSF25 (DR3/TNFRSF25)
Expression for TNFRSF25 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
- T Helper Cells Thymus
- Double Positive Thymocytes Thymus
- T-Cytotoxic Cells Thymus
- cd4+ cells
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- Double Positive Thymocytes Thymus
- T-Cytotoxic Cells Thymus
- Brain (Nervous System)
- Umbilical Cord (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for TNFRSF25 Gene
This gene is overexpressed in Brain - Cerebellum (x9.3) and Brain - Cerebellar Hemisphere (x8.5).
This gene is overexpressed in Adipocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF25 Gene
NURSA nuclear receptor signaling pathways regulating expression of TNFRSF25 Gene:
TNFRSF25SOURCE GeneReport for Unigene cluster for TNFRSF25 Gene:
Hs.462529mRNA Expression by UniProt/SwissProt for TNFRSF25 Gene:
Q93038-TNR25_HUMAN
Tissue specificity:
Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
Evidence on tissue expression from TISSUES for TNFRSF25 Gene
- Nervous system(4.5)
- Heart(4.3)
- Lung(4.3)
- Blood(2.8)
- Skin(2.8)
- Thyroid gland(2.5)
- Intestine(2.4)
- Spleen(2.4)
- Lymph node(2.2)
- Pancreas(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for TNFRSF25
-
OriGene qPCR primer pairs for TNFRSF25
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF25 Gene
Orthologs for TNFRSF25 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TNFRSF25 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | TNFRSF25 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | TNFRSF25 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Tnfrsf25 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tnfrsf25 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TNFRSF25 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TNFRSF25 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TNFRSF25 34 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | TNFRSF25 35 |
|
OneToOne |
- Species where no ortholog for TNFRSF25 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TNFRSF25 Gene
Variants for TNFRSF25 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs114619322 | Likely benign | 6,468,009(+) | GCAGC(C/G)GACTA | intron-variant, upstream-variant-2KB, reference, missense | |
| rs3176900 | Likely benign | 6,466,866(-) | CCACA(C/T)TCAGG | upstream-variant-2KB, utr-variant-3-prime | |
| rs45574533 | Likely benign | 6,466,250(-) | GGGCT(C/T)GGGCG | upstream-variant-2KB, utr-variant-3-prime | |
| rs45604837 | Likely benign | 6,466,259(-) | GACTC(A/G)GTTGG | upstream-variant-2KB, utr-variant-3-prime | |
| rs538175057 | Likely benign | 6,466,798(+) | GTATT(A/T)AAAAA | upstream-variant-2KB, utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2n27 | CNV | loss | 19166990 |
| dgv80n54 | CNV | loss | 21841781 |
| dgv9n67 | CNV | gain | 20364138 |
| esv25412 | CNV | gain+loss | 19812545 |
| nsv1009548 | CNV | loss | 25217958 |
| nsv462061 | CNV | loss | 19166990 |
| nsv470690 | CNV | gain | 18288195 |
| nsv470691 | CNV | loss | 18288195 |
| nsv508836 | CNV | insertion | 20534489 |
| nsv545240 | CNV | loss | 21841781 |
| nsv545264 | CNV | loss | 21841781 |
| nsv545265 | CNV | loss | 21841781 |
| nsv545266 | CNV | loss | 21841781 |
| nsv7880 | CNV | gain+loss | 18304495 |
| nsv831536 | CNV | loss | 17160897 |
| nsv954048 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.56;
65.00% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TNFRSF25 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF25 Gene
Disorders for TNFRSF25 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| punctate epithelial keratoconjunctivitis |
|
|
| juvenile dermatitis herpetiformis |
|
|
| heart block, congenital |
|
|
| autoimmune disease of gastrointestinal tract |
|
|
| superficial keratitis |
|
|
Search TNFRSF25 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for TNFRSF25
No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF25 Gene
Publications for TNFRSF25 Gene
- TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). (PMID: 9052839) Bodmer J.-L. … Tschopp J. (Immunity 1997) 2 3 4 64
- A death-domain-containing receptor that mediates apoptosis. (PMID: 8934525) Kitson J. … Farrow S.N. (Nature 1996) 2 3 4 64
- Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. (PMID: 8875942) Chinnaiyan A.M. … Dixit V.M. (Science 1996) 3 4 22 64
- Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee K.M. … Lan Q. (Am. J. Hematol. 2010) 3 46 64
- Immunology: TL1A in the inflammatory network in autoimmune diseases. (PMID: 20125169) Bayry J. (Nat Rev Rheumatol 2010) 3 22 64
Products for TNFRSF25 Gene
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for TNFRSF25: See all 189
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- antibodies-online Proteins for TNFRSF25: See all 4
- Search antibodies-online for peptides
- GeneTex TNFRSF25 antibody for TNFRSF25
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- VectorBuilder custom plasmid, inducible vectors for TNFRSF25
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TNFRSF25
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TNFRSF25 Gene
- (1) GeneCards
- (2) HGNC
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