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TNFRSF25 Gene

protein-coding GIFtS: 63
GCID: GC01M006521

Tumor Necrosis Factor Receptor Superfamily, Member 25

(Previous names: tumor necrosis factor receptor superfamily, member 12 (translocating...)
(Previous symbol: TNFRSF12)

See TNFRSF25-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 25¹ ²		TRAMP²
TNFRSF12¹ ² ³ ⁵		WSL-1²
DR3² ³ ⁵		WSL-LR²
LARD² ³ ⁵		Apoptosis Inducing Receptor²
Tumor Necrosis Factor Receptor Superfamily, Member 12 (Translocating Chain-Association Membrane Protein)¹ ²		Death Domain Receptor 3 Soluble Form²
Apoptosis-Inducing Receptor AIR² ³		Death Receptor Beta²
Apoptosis-Mediating Receptor DR3² ³		Tumor Necrosis Factor Receptor Superfamily Member 25²
Apoptosis-Mediating Receptor TRAMP² ³		APO3³
Lymphocyte-Associated Receptor Of Death² ³		Apo-3³
Protein WSL-1² ³		WSL³
DDR3² ³		WSL1³
APO-3²		Death Receptor 3³
TR3²		Protein WSL³

External Ids:	HGNC: 11910¹	Entrez Gene: 8718²	Ensembl: ENSG00000215788⁷	OMIM: 603366⁵	UniProtKB: Q93038³

Export aliases for TNFRSF25 gene to outside databases

Previous GC identifers: GC01M006330 GC01M006117 GC01M006230 GC01M006455 GC01M005668

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFRSF25 Gene:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed

preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte

homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The

signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout

studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple

alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of

which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a

programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and

is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. (provided by

RefSeq, Jul 2008)

GeneCards Summary for TNFRSF25 Gene:

TNFRSF25 (tumor necrosis factor receptor superfamily, member 25) is a protein-coding gene. Diseases associated with TNFRSF25 include type 1 diabetes mellitus. GO annotations related to this gene include tumor necrosis factor-activated receptor activity and receptor activity. An important paralog of this gene is TNFRSF1A.

UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038

Function: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of

NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis

Gene Wiki entry for TNFRSF25 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10 NC_018912.2 NT_032977.10

Regulatory elements:

Regulatory transcription factor binding sites in the TNFRSF25 gene promoter:
p53 AP-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNFRSF25 promoter sequence

Search Chromatin IP Primers for TNFRSF25

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF25

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2 Ensembl cytogenetic band: 1p36.31 HGNC cytogenetic band: 1p36.2

TNFRSF25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF25 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M006521: view genomic region (about GC identifiers)

Start:	6,521,211 bp from pter	End:	6,526,255 bp from pter
Size:	5,045 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 25 precursor

Size: 417 amino acids; 45385 Da

Subunit: Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two

distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4

Secondary accessions: B1ALX2 B1ALX3 B7ZLL7 O00275 O00276 O00277 O00278 O00279 O00280 O14865

O14866 P78507 P78515 Q17RU4 Q92983 Q93036 Q93037 Q99722 Q99830 Q99831 Q9BY86 Q9UME0 Q9UME1

Q9UME5

Alternative splicing: 12 isoforms: Q93038-1 Q93038-2 Q93038-3 Q93038-4 Q93038-5 Q93038-6 Q93038-7 Q93038-8

Q93038-9 Q93038-10 Q93038-11 Q93038-12 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for TNFRSF25: NX_Q93038

Explore proteomics data for TNFRSF25 at MOPED

Post-translational modifications:

Glycosylated (Probable)¹

Glycosylation² at Asn67, Asn106

See TNFRSF25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (6 alternative transcripts):

NP_001034753.1 NP_003781.1 NP_683866.1 NP_683867.1 NP_683868.1 NP_683871.1

ENSEMBL proteins:

ENSP00000431554 ENSP00000434129 ENSP00000367013 ENSP00000349341 ENSP00000337713

ENSP00000404274 ENSP00000326762 ENSP00000314451 ENSP00000423121 ENSP00000421976

ENSP00000424071 ENSP00000465381

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	Sino Biological Recombinant Protein for TNFRSF25 Sino Biological Cell Lysate for TNFRSF25
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for TNFRSF25
	Search eBioscience for Proteins for TNFRSF25
	antibodies-online proteins for TNFRSF25 (3 products)
	antibodies-online peptides for TNFRSF25

TNFRSF25 Antibody Products:

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TNFRSF25 Assay Products:

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	Cloud-Clone Corp. ELISAs for TNFRSF25 Cloud-Clone Corp. CLIAs for TNFRSF25
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

TNFRSF: Tumor necrosis factor receptor superfamily

IUPHAR Guide to PHARMACOLOGY protein family classification: death receptor 3

Tumour necrosis factor (TNF) receptor family

4 InterPro protein domains:

IPR001368 TNFR/NGFR_Cys_rich_reg

IPR011029 DEATH-like_dom

IPR000488 Death_domain

IPR022329 TNFR_25

Graphical View of Domain Structure for InterPro Entry Q93038

ProtoNet protein and cluster: Q93038

2 Blocks protein domains:

IPB000488 Death domain

IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038

Similarity: Contains 1 death domain

Similarity: Contains 4 TNFR-Cys repeats

Find genes that share domains with TNFRSF25 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: TNR25_HUMAN, Q93038

Function: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of

NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	NAS	9114039
GO:0005031	tumor necrosis factor-activated receptor activity	TAS	9052839
GO:0005515	protein binding	--	--

Find genes that share ontologies with TNFRSF25 About GenesLikeMe

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tnfrsf25):

cellular

hematopoietic system

immune system

Find genes that share phenotypes with TNFRSF25 About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for TNFRSF25

miRNA Products:		miRTarBase miRNAs that target TNFRSF25: hsa-mir-124-3p (MIRT022463)

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		hsa-miR-3163 hsa-miR-3618 hsa-miR-934 hsa-miR-2909 hsa-miR-3918 hsa-miR-374c hsa-miR-3158-3p hsa-miR-655

		SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF25 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TNFRSF25
		Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF25

Gene Editing
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Clone Products:		OriGene clones in human, mouse for TNFRSF25 (see all 32) OriGene ORF clones in mouse, rat for TNFRSF25 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): TNFRSF25 (NM_003790)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF25

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

TNR25_HUMAN, Q93038: Isoform 1: Cell membrane; Single-pass type I membrane protein

TNR25_HUMAN, Q93038: Isoform 2: Cell membrane; Single-pass type I membrane protein

TNR25_HUMAN, Q93038: Isoform 9: Cell membrane; Single-pass type I membrane protein

TNR25_HUMAN, Q93038: Isoform 11: Cell membrane; Single-pass type I membrane protein

TNR25_HUMAN, Q93038: Isoform 3: Secreted

TNR25_HUMAN, Q93038: Isoform 4: Secreted

TNR25_HUMAN, Q93038: Isoform 5: Secreted

TNR25_HUMAN, Q93038: Isoform 6: Secreted

TNR25_HUMAN, Q93038: Isoform 7: Secreted

TNR25_HUMAN, Q93038: Isoform 8: Secreted

TNR25_HUMAN, Q93038: Isoform 10: Secreted

TNR25_HUMAN, Q93038: Isoform 12: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	5
extracellular	5
plasma membrane	5
endoplasmic reticulum	1
lysosome	1

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Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005829	cytosol	NAS	9114039
GO:0005886	plasma membrane	IDA	11911831
GO:0005887	integral component of plasma membrane	TAS	9052839

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TNFRSF25 About (see all 6)

See pathways by source

Powered
by

SuperPath

Contained pathways About

TNF Signaling

	TNF Signaling	0.50			TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions	0.49
	Death Receptor Signaling	0.50			NF-kB (NFkB) Pathway	0.46

Apoptosis Signaling Pathways

Apoptosis Signaling Pathways

0.35

Apoptosis and survival Apoptotic TNF-family pathways

0.35

Apoptosis (WikiPathways)

Apoptosis Modulation and Signaling

0.38

Apoptosis

0.38

Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

0.46

PEDF Induced Signaling

Cytokine-cytokine receptor interaction

0.43

Find genes that share SuperPaths with TNFRSF25 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

2 R&D Systems Pathways for TNFRSF25

	TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
	Apoptosis Signaling Pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF25 (see all 15)

	TWEAK Pathway
	STAT3 Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Glucocorticoid Receptor Signaling

1 Cell Signaling Technology (CST) Pathway for TNFRSF25

Apoptosis and Autophagy

2 GeneGo (Thomson Reuters) Pathways for TNFRSF25

	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
	Apoptosis and survival Apoptotic TNF-family pathways

2 BioSystems Pathways for TNFRSF25

	Apoptosis
	Apoptosis Modulation and Signaling

3 Sino Biological Pathways for TNFRSF25

	TNF Signaling
	Death Receptor Signaling
	NF-kB (NFkB) Pathway

1 Kegg Pathway (Kegg details for TNFRSF25):

Cytokine-cytokine receptor interaction

Pathway & Disease-focused RT² Profiler PCR Arrays including TNFRSF25:

TNF Ligands & Receptors in human mouse rat

Neurotoxicity in human mouse rat

Apoptosis 384HT in human mouse rat

Apoptosis in human mouse rat

Necrosis in human mouse rat

Interactions:

GeneGlobe Interaction Network for TNFRSF25

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

Selected Interacting proteins for TNFRSF25 (Q93038³ ENSP00000367013⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRADD	Q15628³, ENSP00000341268⁴	I2D: score=3 STRING: ENSP00000341268
BAG4	O95429³, ENSP00000287322⁴	I2D: score=2 STRING: ENSP00000287322
MAPK1	P28482³, ENSP00000215832⁴	I2D: score=2 STRING: ENSP00000215832
NOL3	O60936³, ENSP00000268605⁴	I2D: score=1 STRING: ENSP00000268605
TNFSF15	O95150³, ENSP00000363157⁴	I2D: score=2 STRING: ENSP00000363157

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Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	NAS	9114039
GO:0007165	signal transduction	TAS	8875942
GO:0007166	cell surface receptor signaling pathway	TAS	9052839
GO:0033209	tumor necrosis factor-mediated signaling pathway	TAS	9052839
GO:0042981	regulation of apoptotic process	NAS	9114039

Find genes that share ontologies with TNFRSF25 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for TNFRSF25 (TNR25)

1 IUPHAR Ligand for TNFRSF25 (death receptor 3) About this table

Ligand	Type	Action	Affinity	Pubmed IDs
TL1A	None	None		--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TNFRSF25 gene (9 alternative transcripts):

NM_001039664.1 NM_003790.2 NM_148965.1 NM_148966.1 NM_148967.1 NM_148970.1 NM_148968.1 NM_148969.1

NM_148974.1

Unigene Cluster for TNFRSF25:

Tumor necrosis factor receptor superfamily, member 25

Hs.462529 [show with all ESTs]

Unigene Representative Sequence: Y09392

Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000473343 ENST00000513135 ENST00000485036 ENST00000480393 ENST00000377782(uc001anh.3)

ENST00000356876(uc001ana.3 uc001anb.3 uc001anc.3 uc001and.3 uc009vlz.3 uc001ane.3 uc001anf.3 uc001ang.3)

ENST00000351959 ENST00000414040 ENST00000351748 ENST00000348333 ENST00000502588

ENST00000502730 ENST00000510563 ENST00000453260 ENST00000475730 ENST00000469691

ENST00000481401 ENST00000461703

miRNA Products:		Block miRNA regulation of human, mouse, rat TNFRSF25 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TNFRSF25 (see all 10):
		hsa-miR-3163 hsa-miR-3618 hsa-miR-934 hsa-miR-2909 hsa-miR-3918 hsa-miR-374c hsa-miR-3158-3p hsa-miR-655

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		QuantiFast Probe-based Assays in human, mouse, rat TNFRSF25

Additional mRNA sequence:

AB308321.1 AF026070.1 AY358309.1 BC117189.1 BC143886.1 U72763.1 U74611.1 U75380.1

U75381.1 U78029.1 U83597.1 U83598.1 U94501.1 U94502.1 U94508.1 U94509.1

U94510.1 U94511.1 U94512.1 Y09392.1

14 DOTS entries:

DT.92431005 DT.86847342 DT.100790315 DT.99933149 DT.97763290 DT.100790318 DT.86847340 DT.121426091

DT.121426124 DT.75112427 DT.95250774 DT.101984073 DT.92005786 DT.99948401

Selected AceView cDNA sequences (see all 180):

BM794760 BC042606 AI963243 AW050746 AB018263 AK024676 AK125550 U94506

U94501 AW134494 AK096347 NM_148965 AI805704 AK131074 NM_148973 NM_148974

U94502 Z39975 NM_198681 AK128021 NM_148971 BC015231 AW452241 AI275938

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TNFRSF25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGGCTGGACG

About this image

TNFRSF25 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 5) fully expand


Blood (Cardiovascular System) fully expand to see all 10 entries
T Helper Cells Peripheral Blood
Peripheral blood Pan-T Cells
cd4+ t cells

Thymus (Hematopoietic System) fully expand to see all 3 entries
T Helper Cells Thymus

Umbilical Cord (Extraembryonic Tissues)
Cord Blood Pan-T Cells

Brain (Nervous System)
Cerebellum

Spleen (Hematopoietic System)

TNFRSF25 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TNFRSF25 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.462529

UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038

Tissue specificity: Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such

as thymus, colon, intestine, and spleen. Also found in the prostate

Pathway & Disease-focused RT² Profiler PCR Arrays including TNFRSF25:

TNF Ligands & Receptors in human mouse rat

Neurotoxicity in human mouse rat

Apoptosis 384HT in human mouse rat

Apoptosis in human mouse rat

Necrosis in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for TNFRSF25 OriGene qSTAR qPCR primer pairs in human, mouse for TNFRSF25
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF25

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF25 gene from Selected species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tnfrsf25^{1 , 5}	tumor necrosis factor receptor superfamily, member more^{1, 5}	75.7(n)¹ 69.16(a)¹		4 (82.89 cM)⁵ 85030¹ NM_033042.3¹ NP_149031.2¹ 152115934⁵
chicken (Gallus gallus)	Aves	TNFRSF25¹	tumor necrosis factor receptor superfamily, member more	54.17(n) 42.9(a)		425564 XM_423315.4 XP_423315.4
zebrafish (Danio rerio)	Actinopterygii	TNFRSF25⁶	tumor necrosis factor receptor superfamily, member...	22(a)	1 ↔ 1	23(21060592-21068774) ENSDARG00000089868

ENSEMBL Gene Tree for TNFRSF25 (if available)
TreeFam Gene Tree for TNFRSF25 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TNFRSF25 gene

TNFRSF1A²

Find genes that share paralogs with TNFRSF25 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140642935^1,2		--	6524252(+)	`TAAGGC/TGGATC`	6	--	int¹ ut3¹		0	--	--	--	--
rs45599832^1,2	C,F	--	6524367(-)	`TGGGGC/AAGGTG`	6	--	int¹ ut3¹		2		NS WA	284
rs115539300^1,2	C	--	6524415(+)	`CCATCC/TCACGA`	6	--	int¹ ut3¹		1		WA	118
rs182922043^1,2	C	--	6524490(+)	`GGTCCA/CACAGT`	11	G W	mis¹ int¹		0	--	--	--	--
rs11800462^1,2,,4	C,F,A,H	--	6524501(+)	`CAGTAT/CCTCTG`	11	/D /G	mis¹ int¹		24		NS EA NA CSA WA EU	8137
rs199634892^1,2	C	--	6524519(+)	`CTGCAA/GTCCAG`	6	--	int¹		0	--	--	--	--
rs45558632^1,2	C	--	6524596(-)	`CCACCC/TAGGGC`	6	--	int¹		1		NS	162
rs201638946^1,2		--	6524600(+)	`TGGGTA/GGGGGT`	6	--	int¹		0	--	--	--	--
rs77388372^1,2	C	--	6524639(+)	`CAGGGC/GCCCGC`	11	P A	mis¹ int¹		0	--	--	--	--
rs35137293^1,2	C,F	--	6524649(+)	`CAGTCT/CAGGCA`	11	/L	syn¹ int¹		8		NA NS CSA WA EU	5422

HapMap Linkage Disequilibrium report for TNFRSF25 (6521211 - 6526255 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for TNFRSF25 (see all 19): About this table

Variant ID	Type	Subtype	PubMed ID
nsv508836	CNV	Insertion	20534489
nsv470691	CNV	Loss	18288195
nsv871698	CNV	Loss	21882294
nsv462061	CNV	Loss	19166990
nsv871719	CNV	Loss	21882294
nsv870465	CNV	Loss	21882294
dgv127n71	CNV	Loss	21882294
dgv119n71	CNV	Loss	21882294
dgv125n71	CNV	Loss	21882294
nsv831536	CNV	Loss	17160897

Human Gene Mutation Database (HGMD): TNFRSF25

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603366 OMIM disorders: --

1 disease for TNFRSF25:
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type 1 diabetes mellitus

Find genes that share disorders with TNFRSF25 About GenesLikeMe

2 Novoseek inferred disease relationships for TNFRSF25 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	48.4	7	18824582 (1), 11216825 (1), 14965271 (1), 11455969 (1) (see all 7)
tumors	31.3	7	18824582 (1), 11216825 (1), 14965271 (1), 15694416 (1) (see all 7)

Genetic Association Database (GAD): TNFRSF25
Human Genome Epidemiology (HuGE) Navigator: TNFRSF25 (6 documents)

Export disorders for TNFRSF25 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TNFRSF25 gene, integrated from 10 sources (see all 72):
(articles sorted by number of sources associating them with TNFRSF25)

Utopia: connect your pdf to the dynamic
world of online information

TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). (PubMed id 9052839)^{1, 2, 3} Bodmer J.-L.... Tschopp J. (Immunity 1997)
A death-domain-containing receptor that mediates apoptosis. (PubMed id 8934525)^{1, 2, 3} Kitson J.... Farrow S.N. (Nature 1996)
Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. (PubMed id 8875942)^{1, 2, 9} Chinnaiyan A.M.... Dixit V.M. (Science 1996)
Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)^{1, 4} Lee K.M....Lan Q. (Am. J. Hematol. 2010)
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)^{1, 4} Hosgood H.D....Lan Q. (Occup Environ Med 2009)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{1, 2} Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PubMed id 15301860)^{1, 4} Cho S.M....Lee J.K. (Hum. Immunol. 2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (Genome Res. 2003)
Relationship of large multifunctional proteasome 7 gene polymorphism with susceptibility to type 1 diabetes mellitus and DR3 gene. (PubMed id 11793848)^{1, 4} Ding H....Yang G. (Chin. Med. J. 2001)
The relationship of lmp2 and DR3 genes with susceptibility to type I diabetes mellitus in south China Han population. (PubMed id 11819535)^{1, 4} Ding H.L....Yan T. (World J. Gastroenterol. 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8718	HGNC: 11910	AceView: TNFRSF25andKIAA0720	Ensembl:ENSG00000215788	euGenes: HUgn8718
ECgene: TNFRSF25	Kegg: 8718	H-InvDB: TNFRSF25

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TNFRSF25	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFRSF25	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/tnfrsf25/

Intellectual Property for TNFRSF25 gene
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Patent Information for TNFRSF25 gene:
Search GeneIP for patents involving TNFRSF25

GeneCards and IP:
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TNFRSF25 Gene

Tumor Necrosis Factor Receptor Superfamily, Member 25

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TNFRSF25 (Gene Symbol)
Tumor Necrosis Factor Receptor Superfamily, Member 25
TNFRSF12
DR3
LARD
Tumor Necrosis Factor Receptor Superfamily, Member 12 (Translocating Chain-Association Membrane Protein)
Apoptosis-Inducing Receptor AIR
Apoptosis-Mediating Receptor DR3
Apoptosis-Mediating Receptor TRAMP
Lymphocyte-Associated Receptor Of Death
Protein WSL-1
DDR3
APO-3
TR3
TRAMP
WSL-1
WSL-LR
Apoptosis Inducing Receptor
Death Domain Receptor 3 Soluble Form
Death Receptor Beta
Tumor Necrosis Factor Receptor Superfamily Member 25
APO3
Apo-3
WSL
WSL1
Death Receptor 3
Protein WSL

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TNFRSF25 Gene

Tumor Necrosis Factor Receptor Superfamily, Member 25

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