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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF25 Gene

protein-coding   GIFtS: 59
GCID: GC01M006521

tumor necrosis factor receptor superfamily, member 25

(Previous names: tumor necrosis factor receptor superfamily, member 12 (translocating...)
(Previous symbol: TNFRSF12)
 Explore 15 diseases affiliated with
TNFRSF25 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TNFRSF25    

Aliases
for TNFRSF25 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 251 2     Apoptosis-Mediating Receptor TRAMP2 3
DR31 2 3 5     Lymphocyte-Associated Receptor Of Death2 3
LARD1 2 3 5     Protein WSL-12 3
TNFRSF121 2 3 5     Apoptosis Inducing Receptor2
DDR31 2 3     Death Domain Receptor 3 Soluble Form2
APO-31 2     Death Receptor Beta2
TR31 2     Tumor Necrosis Factor Receptor Superfamily Member 252
TRAMP1 2     APO33
WSL-11 2     Apo-33
WSL-LR1 2     WSL3
Tumor Necrosis Factor Receptor Superfamily, Member 12 (Translocating
Chain-Association Membrane Protein)1 2
     WSL13
Apoptosis-Inducing Receptor AIR2 3     Death Receptor 33
Apoptosis-Mediating Receptor DR32 3     Protein WSL3

External Ids:    HGNC: 119101   Entrez Gene: 87182   Ensembl: ENSG000002157887   OMIM: 6033665   UniProtKB: Q930383   

Export aliases for TNFRSF25 gene to outside databases

Previous GC identifers: GC01M006330 GC01M006117 GC01M006230 GC01M006455 GC01M005668


Summaries
for TNFRSF25 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TNFRSF25:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially
in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has
been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is
mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene
in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene
encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative
splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly
produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation
induced by T-cell activation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038
Function: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of
NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis

Gene Wiki entry for TNFRSF25


Genomic Views
for TNFRSF25 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF25 gene promoter:
         p53   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNFRSF25 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF25

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2   Ensembl cytogenetic band:  1p36.31   HGNC cytogenetic band: 1p36.2

TNFRSF25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF25 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M006521:  view genomic region     (about GC identifiers)

Start:
 6,521,211 bp from pter      End:
 6,526,255 bp from pter
Size:
 5,045 bases      Orientation:
 minus strand

Proteins
for TNFRSF25 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 25 precursor  
Size: 417 amino acids; 45385 Da
Subunit: Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct
signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 9: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 11: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 3: Secreted
Subcellular location: Isoform 4: Secreted
Subcellular location: Isoform 5: Secreted
Subcellular location: Isoform 6: Secreted
Subcellular location: Isoform 7: Secreted
Subcellular location: Isoform 8: Secreted
Subcellular location: Isoform 10: Secreted
Subcellular location: Isoform 12: Secreted
Secondary accessions: B1ALX2 B1ALX3 B7ZLL7 O00275 O00276 O00277 O00278 O00279 O00280 O14865 O14866
P78507 P78515 Q17RU4 Q92983 Q93036 Q93037 Q99722 Q99830 Q99831 Q9BY86 Q9UME0 Q9UME1 Q9UME5
Alternative splicing: 12 isoforms:  Q93038-1   Q93038-2   Q93038-3   Q93038-4   Q93038-5   Q93038-6   Q93038-7   Q93038-8   
Q93038-9   Q93038-10   Q93038-11   Q93038-12   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for TNFRSF25: NX_Q93038

Post-translational modifications:

  • Glycosylated (Probable)1
  • View neXtProt modification sites for NX_Q93038

    • TNFRSF25 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001034753.1  NP_003781.1  NP_683866.1  NP_683867.1  NP_683868.1  NP_683871.1  

    ENSEMBL proteins: 
     ENSP00000431554   ENSP00000434129   ENSP00000367013   ENSP00000349341   ENSP00000337713  
     ENSP00000404274   ENSP00000326762   ENSP00000314451   ENSP00000423121   ENSP00000421976  
     ENSP00000424071   ENSP00000465381  

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    Uscn Proteins for TNFRSF25

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005829cytosol NAS9114039
    GO:0005886plasma membrane IDA11911831
    GO:0005887integral to plasma membrane TAS9052839


    TNFRSF25 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TNFRSF25 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TNFRSF25 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR011029 DEATH-like_dom
     IPR000488 Death_domain
     IPR022329 TNFR_25

    Graphical View of Domain Structure for InterPro Entry Q93038

    ProtoNet protein and cluster: Q93038

    2 Blocks protein families:
    IPB000488 Death domain
    IPB001368 TNFR/CD27/30/40/95 cysteine-rich region


    UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038
    Similarity: Contains 1 death domain
    Similarity: Contains 4 TNFR-Cys repeats


    Function
    for TNFRSF25 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038
    Function: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of
    NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis

    miRNA
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    hsa-miR-3163 hsa-miR-3618 hsa-miR-934 hsa-miR-2909 hsa-miR-3918 hsa-miR-374c hsa-miR-3158-3p hsa-miR-655
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity NAS9114039
    GO:0005031tumor necrosis factor-activated receptor activity TAS9052839


    TNFRSF25 for ontologies           About GeneDecksing


    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tnfrsf25):
     cellular  hematopoietic system  immune system 

    TNFRSF25 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TNFRSF25 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptosis and survival_Apoptotic TNF-family pathways
    		Apoptosis and survival_Apoptotic TNF-family pathways1.00
    		Apoptosis Signaling Pathways0.35
    		Apoptosis and survival Apoptotic TNF-family pathways1.00
    2Apoptosis Modulation and Signaling
    		Apoptosis Modulation and Signaling1.00
    		Apoptosis0.38
    3Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    		Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway0.46
    		Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway0.46
    4Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    5PEDF Induced Signaling
    		Cytokine-cytokine receptor interaction0.26

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for TNFRSF25
        Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

    2 R&D Systems Pathways for TNFRSF25
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    Apoptosis Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for TNFRSF25
        Apoptosis and Autophagy

    2 GeneGo (Thomson Reuters) Pathways for TNFRSF25
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival Apoptotic TNF-family pathways

    2 BioSystems Pathways for TNFRSF25 
        Apoptosis Modulation and Signaling
    Apoptosis


    1         Kegg Pathway  (Kegg details for TNFRSF25):
        Cytokine-cytokine receptor interaction


    TNFRSF25 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/20 Interacting proteins for TNFRSF25 (Q930383 ENSP000003670134) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRADDQ156283, ENSP000003412684I2D: score=3 STRING: ENSP00000341268
    BAG4O954293, ENSP000002873224I2D: score=2 STRING: ENSP00000287322
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    NOL3O609363, ENSP000002686054I2D: score=1 STRING: ENSP00000268605
    TNFSF15O951503, ENSP000003631574I2D: score=2 STRING: ENSP00000363157
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process NAS9114039
    GO:0006917induction of apoptosis TAS8875942
    GO:0007165signal transduction TAS8994832
    GO:0007166cell surface receptor signaling pathway TAS9052839
    GO:0033209tumor necrosis factor-mediated signaling pathway TAS9052839


    TNFRSF25 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TNFRSF25 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TNFRSF25
    Search CenterWatch for drugs/clinical trials and news about TNFRSF25 / TNR25 

    Transcripts
    for TNFRSF25 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TNFRSF25 gene (9 alternative transcripts): 
    NM_001039664.1  NM_003790.2  NM_148965.1  NM_148966.1  NM_148967.1  NM_148970.1  NM_148968.1  NM_148969.1  
    NM_148974.1  

    Unigene Cluster for TNFRSF25:

    Tumor necrosis factor receptor superfamily, member 25
    Hs.462529  [show with all ESTs]
    Unigene Representative Sequence: Y09392
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000473343 ENST00000513135 ENST00000485036 ENST00000480393 ENST00000377782(uc001anh.3)
    ENST00000356876(uc001ana.3 uc001anb.3 uc001anc.3 uc001and.3 uc009vlz.3 uc001ane.3 uc001anf.3 uc001ang.3)
    ENST00000351959 ENST00000414040 ENST00000351748 ENST00000348333 ENST00000502588
    ENST00000502730 ENST00000510563 ENST00000453260 ENST00000475730 ENST00000469691
    ENST00000481401 ENST00000461703

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFRSF25 (see all 10):
    hsa-miR-3163 hsa-miR-3618 hsa-miR-934 hsa-miR-2909 hsa-miR-3918 hsa-miR-374c hsa-miR-3158-3p hsa-miR-655
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    Additional cDNA sequence: 

    AB308321.1 AF026070.1 AY358309.1 BC117189.1 BC143886.1 U72763.1 U74611.1 U75380.1 
    U75381.1 U78029.1 U83597.1 U83598.1 U94501.1 U94502.1 U94508.1 U94509.1 
    U94510.1 U94511.1 U94512.1 Y09392.1 

    14 DOTS entries:

    DT.92431005  DT.86847342  DT.100790315  DT.99933149  DT.97763290  DT.100790318  DT.86847340  DT.121426091 
    DT.121426124  DT.75112427  DT.95250774  DT.101984073  DT.92005786  DT.99948401 

    24/180 AceView cDNA sequences (see all 180):

    AI805704 NM_148970 U74611 BM794760 CD674411 NM_148972 U94508 BC042606 
    AK131074 BU500889 U94502 NM_148971 AK094463 BM792178 NM_148973 CR619991 
    BM850652 AI275938 U78029 AW273007 BM783979 BE563566 U94503 AK024676 

    GeneLoc Exon Structure


    Expression
    for TNFRSF25 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFRSF25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGCTGGACG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TNFRSF25 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFRSF25

    SOURCE GeneReport for Unigene cluster: Hs.462529

    UniProtKB/Swiss-Prot: TNR25_HUMAN, Q93038
    Tissue specificity: Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as
    thymus, colon, intestine, and spleen. Also found in the prostate

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF25: 
              TNF Ligands & Receptors in human mouse rat
              Neurotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat
              Necrosis in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for TNFRSF25 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF25 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TNFRSF251 tumor necrosis factor receptor superfamily, member more 52.34(n)
    41.01(a)    		   425564  XM_423315.3  XP_423315.3 
    zebrafish
    (Danio rerio)    		 Actinopterygii CR339046.26
    		 --
    		 21(a)
    		 1 ↔ 1
    		 23(21060592-21068774)


    ENSEMBL Gene Tree for TNFRSF25 (if available)
    TreeFam Gene Tree for TNFRSF25 (if available) 

    Paralogs
    for TNFRSF25 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFRSF25 gene
    TNFRSF1A2  

    TNFRSF25 for paralogs           About GeneDecksing



    Genomic Variants
    for TNFRSF25 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/164 NCBI SNPs in TNFRSF25 are shown (see all 164)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs456259371,2
    		C,--5668485(-) AGGGTC/AGGGAT 1 -- ut311Minor allele frequency- A:0.01NS 178
    rs29867581,2
    		C,F,H,--5668693(-) AGGGAT/GTCGAA 1 -- ds500119Minor allele frequency- G:0.30MN EA NS NA WA CSA 2254
    rs31381571,2
    		C,F,--5668713(-) AGTGGA/TCTGGA 1 -- ds50012Minor allele frequency- T:0.02NS NA 294
    rs454814031,2
    		C,F,--5668821(-) CTCAAC/TTTCTC 1 -- ds50012Minor allele frequency- T:0.02NS WA 274
    rs115568161,2
    		C--5668854(+) CATTCG/TTTCGT 1 -- ds50012Minor allele frequency- T:0.00NA 4
    rs790966211,2
    		--5673285(+) GCCCCA/GGGCAG 8 -- ds50010--------
    rs456260391,2
    		C,--5673368(-) GGGCTG/CGTAAG 8 -- ds50013Minor allele frequency- C:0.05NS CSA WA 296
    rs15365931,2
    		C,F,--5673458(+) ACTGAT/CAATGC 8 -- ds50018Minor allele frequency- C:0.08MN NA NS WA CSA 644
    rs115746601,2
    		C,F,--5673463(-) GCAGAG/ACATTA 8 -- ds50013Minor allele frequency- A:0.08NA NS 336
    rs30074161,2
    		C,F,--5673551(+) CGGAAA/GGNNNN 8 -- ds50019Minor allele frequency- G:0.25NA NS WA CSA 464

    HapMap Linkage Disequilibrium report for TNFRSF25 (6521211 - 6526255 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for TNFRSF25
         6 CNVs: 70912 84031 53700 74316 30364 4201
    Human Gene Mutation Database (HGMD): TNFRSF25

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    Disorders / Diseases
    for TNFRSF25 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TNFRSF25 for disorders           About GeneDecksing

    OMIM gene information: 603366    OMIM disorders: --

    15 diseases for TNFRSF25:    About MalaCards
    immunoglobulin alpha deficiency    hypersensitivity reaction type ii disease    non-hodgkin lymphoma    type 1 diabetes mellitus
    hodgkin's lymphoma    diabetes mellitus    addison's disease    multiple myeloma
    rheumatoid arthritis    polycythemia    myeloma    arthritis
    neuroblastoma    leukemia    prostatitis

    2 Novoseek disease relationships for TNFRSF25 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 48.4 7 18824582 (1), 11216825 (1), 14965271 (1), 11455969 (1) (see all 7)
    tumors 31.3 7 18824582 (1), 11216825 (1), 14965271 (1), 15694416 (1) (see all 7)

    Genetic Association Database (GAD): TNFRSF25
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF25 (6 documents)

    Export disorders for TNFRSF25 gene to outside databases

    Publications
    for TNFRSF25 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFRSF25 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with TNFRSF25)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). (PubMed id 9052839)1, 2, 3 Bodmer J.-L.... Tschopp J. (1997)
    2. A death-domain-containing receptor that mediates apoptosis. (PubMed id 8934525)1, 2, 3 Kitson J....Farrow S.N. (1996)
    3. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. (PubMed id 8875942)1, 2, 9 Chinnaiyan A.M.... Dixit V.M. (1996)
    4. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Relationship of large multifunctional proteasome 7 gene polymorphism with susceptibility to type 1 diabetes mellitus and DR3 gene. (PubMed id 11793848)1, 4 Ding H....Yang G. (2001)
    7. The relationship of lmp2 and DR3 genes with susceptibility to type I diabetes mellitus in south China Han population. (PubMed id 11819535)1, 4 Ding H.L....Yan T. (2000)
    8. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. (PubMed id 9915703)1, 2 Jiang Y....Goeddel D.V. (1999)
    9. A new death receptor 3 isoform: expression in human lymphoid cell lines and non-Hodgkin's lymphomas. (PubMed id 9446802)1, 2 Warzocha K....Salles G. (1998)
    10. LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing. (PubMed id 9114039)1, 2 Screaton G.R.... Bell J.I. (1997)

    External Searches for TNFRSF25 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TNFRSF25 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8718 HGNC: 11910 AceView: TNFRSF25andKIAA0720 Ensembl:ENSG00000215788 euGenes: HUgn8718
    ECgene: TNFRSF25 Kegg: 8718 H-InvDB: TNFRSF25

    Other Databases showing TNFRSF25 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TNFRSF25 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFRSF25 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF25 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf25/

    Intellectual Property
    for TNFRSF25 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TNFRSF25 gene:
    Search GeneIP for patents involving TNFRSF25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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