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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF21 Gene

protein-coding   GIFtS: 66
GCID: GC06M047246

tumor necrosis factor receptor superfamily, member 21
 Explore 10 diseases affiliated with
TNFRSF21 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TNFRSF21    

Aliases
for TNFRSF21 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 211 2     BM-0182
DR61 2 3     TNFR-Related Death Receptor 62
CD3581 2     Tumor Necrosis Factor Receptor Superfamily Member 212
Death Receptor 62 3     CD358 Antigen3

External Ids:    HGNC: 134691   Entrez Gene: 272422   Ensembl: ENSG000001460727   OMIM: 6057325   UniProtKB: O755093   

Export aliases for TNFRSF21 gene to outside databases

Previous GC identifers: GC06M047199 GC06M047307 GC06M046922


Summaries
for TNFRSF21 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TNFRSF21:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate
NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD
protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in
mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune
regulation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNR21_HUMAN, O75509
Function: May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation.
Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of
surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP
(N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via
caspase-3) and axons (via caspase-6)

Gene Wiki entry for TNFRSF21


Genomic Views
for TNFRSF21 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF21 gene promoter:
         HFH-3   IRF-1   FOXI1   MZF-1   CREB   Ik-2   deltaCREB   IRF-7A   Meis-1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF21 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p21.1

TNFRSF21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF21 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M047246:  view genomic region     (about GC identifiers)

Start:
 47,199,268 bp from pter      End:
 47,277,680 bp from pter
Size:
 78,413 bases      Orientation:
 minus strand

Proteins
for TNFRSF21 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TNR21_HUMAN, O75509 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 21 precursor  
Size: 655 amino acids; 71845 Da
Subunit: Associates with TRADD. Interacts with N-APP (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein (Probable)
Caution: It is uncertain whether Met-1 or Met-25 is the initiator
Sequence caution: Sequence=AAH10241.1; Type=Erroneous initiation;
6/7 PDB 3D structures from and Proteopedia for TNFRSF21 (see all 7):
2DBH (3D)        3QO4 (3D)        3U3P (3D)        3U3Q (3D)        3U3S (3D)        3U3T (3D)    
Secondary accessions: B2RDI9 Q0D2P5 Q96D86

Explore the universe of human proteins at neXtProt for TNFRSF21: NX_O75509

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75509

    • TNFRSF21 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055267.1  
    ENSEMBL proteins: 
     ENSP00000296861  
    Reactome Protein details: O75509
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for TNFRSF21 (DR6/TNFRSF21)
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    OriGene Protein Over-expression Lysate: TNFRSF21
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    Novus Biologicals TNFRSF21 Proteins
    Novus Biologicals TNFRSF21 Lysates
    Sino Biological Recombinant Protein for TNFRSF21
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TNFRSF21

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0030424axon IEA--


    TNFRSF21 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TNFRSF21 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TNFRSF21 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR022330 TNFR_21
     IPR011029 DEATH-like_dom
     IPR000488 Death_domain

    Graphical View of Domain Structure for InterPro Entry O75509

    ProtoNet protein and cluster: O75509

    1 Blocks protein family: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNR21_HUMAN, O75509
    Similarity: Contains 1 death domain
    Similarity: Contains 4 TNFR-Cys repeats


    Function
    for TNFRSF21 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TNR21_HUMAN, O75509
    Function: May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation.
    Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of
    surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP
    (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via
    caspase-3) and axons (via caspase-6)

    miRNA
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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFRSF21 (see all 18):
    hsa-miR-495 hsa-miR-106a hsa-miR-519a hsa-miR-9 hsa-miR-93 hsa-miR-7-1* hsa-miR-526b* hsa-miR-17
    SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF21 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFRSF21 (see all 7)
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF21 (see all 3)
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    Cell Line
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    LifeMap BioReagents: cell line associated with TNFRSF21: PureStem Z11, Meso Progenitor

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI19225519


    TNFRSF21 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for TNFRSF21:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
         Mouse knock-outs for TNFRSF21: Tnfrsf21tm1Ddy Tnfrsf21tm1Vmd
         7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Tnfrsf21):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     nervous system  no phenotypic analysis 

    TNFRSF21 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TNFRSF21 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    		PPARA Activates Gene Expression0.74
    2Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    3Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    4Apoptosis and survival_Apoptotic TNF-family pathways
    		Apoptosis and survival_Apoptotic TNF-family pathways1.00
    		Apoptosis and survival Apoptotic TNF-family pathways1.00
    5PEDF Induced Signaling
    		STAT3 Pathway0.47
    		Cytokine-cytokine receptor interaction0.26

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TNFRSF21
        Apoptosis and survival Apoptotic TNF-family pathways

    1 R&D Systems Pathway for TNFRSF21
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF21 (see all 8)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling
    Apoptosis through Death Receptors

    1 Cell Signaling Technology (CST) Pathway for TNFRSF21
        Apoptosis and Autophagy

    1 GeneGo (Thomson Reuters) Pathway for TNFRSF21
        Apoptosis and survival Apoptotic TNF-family pathways

    1 BioSystems Pathway for TNFRSF21 
        Apoptosis

    5/6        Reactome Pathways for TNFRSF21 (see all 6)
        Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Expression of TNFRSF21
    Metabolism
    PPARA Activates Gene Expression
    Fatty acid, triacylglycerol, and ketone body metabolism


    1         Kegg Pathway  (Kegg details for TNFRSF21):
        Cytokine-cytokine receptor interaction


    TNFRSF21 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/17 Interacting proteins for TNFRSF21 (O755091, 2, 3 ENSP000002968614) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MATR3P432432, 3, ENSP000003543464MINT-8274599 I2D: score=2 STRING: ENSP00000354346
    APPP050671, 3, ENSP000002849814EBI-2313231,EBI-77613 I2D: score=1 STRING: ENSP00000284981
    WASH2PQ6VEQ52, 3MINT-8274621 I2D: score=1 
    STX11O755582, 3, ENSP000003565404MINT-8274610 I2D: score=2 STRING: ENSP00000356540
    TRADDQ156283, ENSP000003412684I2D: score=3 STRING: ENSP00000341268
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0044255cellular lipid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0051402neuron apoptotic process IEA--


    TNFRSF21 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TNFRSF21 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNFRSF21 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFRSF21
    1 Novoseek chemical compound relationship for TNFRSF21 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 13.8 1 15255181 (1)

    Search CenterWatch for drugs/clinical trials and news about TNFRSF21 / TNR21 

    Transcripts
    for TNFRSF21 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TNFRSF21 gene: 
    NM_014452.3  

    Unigene Cluster for TNFRSF21:

    Tumor necrosis factor receptor superfamily, member 21
    Hs.443577  [show with all ESTs]
    Unigene Representative Sequence: AB209394
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000296861(uc003oyv.3)

    miRNA
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    hsa-miR-495 hsa-miR-106a hsa-miR-519a hsa-miR-9 hsa-miR-93 hsa-miR-7-1* hsa-miR-526b* hsa-miR-17
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB209394.1 AF068868.1 AF208860.1 AJ420531.1 AK001504.1 AK025399.1 AK315560.1 AY358304.1 
    BC005192.1 BC010241.1 BC015466.1 BC017730.2 BC021572.1 BT007420.1 CR457190.1 

    8 DOTS entries:

    DT.99977377  DT.213002  DT.99981959  DT.95307093  DT.121364844  DT.121364863  DT.91757160  DT.99953782 

    24/180 AceView cDNA sequences (see all 180):

    CB850836 BM701729 AF208860 BQ233192 AA554244 CB266687 AK025399 AA351536 
    AA555059 BQ688267 BQ019036 AY358304 AI926602 BC017730 AA621819 BT007420 
    BQ575082 CA419857 AF068868 CA454584 BM989084 AA993112 AI690623 BM977896 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF21    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
    SP1:              -                                       
    SP2:              -                                       
    SP3:                                                      


    ECgene alternative splicing isoforms for TNFRSF21

    Expression
    for TNFRSF21 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFRSF21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTGAAACTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TNFRSF21 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    BrainMeningesBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    Extraembryonic endoderm-like cells (Generation of extrae...)

    See TNFRSF21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFRSF21

    SOURCE GeneReport for Unigene cluster: Hs.443577

    UniProtKB/Swiss-Prot: TNR21_HUMAN, O75509
    Tissue specificity: Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at
    lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal
    liver. Very low levels were found in adult liver and peripheral blood leukocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF21: 
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              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF21

    Orthologs
    for TNFRSF21 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF21 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TNFRSF211 tumor necrosis factor receptor superfamily, member more 73.12(n)
    75.48(a)    		   422062  NM_001031103.1  NP_001026274.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TNFRSF216
    		 --
    		 65(a)
    		 1 ↔ 1
    		 1(138321758-138347206)
    zebrafish
    (Danio rerio)    		 Actinopterygii tnfrsf211 tumor necrosis factor receptor superfamily, member more 60.61(n)
    61.42(a)    		   564874  NM_001042688.2  NP_001036153.2 


    ENSEMBL Gene Tree for TNFRSF21 (if available)
    TreeFam Gene Tree for TNFRSF21 (if available) 

    Paralogs
    for TNFRSF21 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFRSF21 gene
    TNFRSF6B2  CD402  TNFRSF1B2  TNFRSF42  TNFRSF11A2  TNFRSF92  NGFR2  TNFRSF142  
    TNFRSF11B2  LTBR2  

    TNFRSF21 for paralogs           About GeneDecksing



    Genomic Variants
    for TNFRSF21 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1333 NCBI SNPs in TNFRSF21 are shown (see all 1333)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1445960891,2
    		--47198841(+) AATAAA/GGACAA 1 -- ds50010--------
    rs1165846241,2
    		F,--47198878(+) ATCCAA/GAAGAC 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1828247661,2
    		--47199005(+) ATTCAC/TTGCAT 1 -- ds50010--------
    rs728619871,2
    		--47199013(+) CATGTC/TTCCCT 1 -- ds50010--------
    rs734736101,2
    		C,--47199082(+) TCCTCC/TTTCAG 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1385350141,2
    		--47199108(+) GGATGC/TCCTGC 1 -- ds50010--------
    rs728619881,2
    		C,--47199113(+) CCCTGA/CCTGAA 1 -- ds50010--------
    rs745880591,2
    		--47199136(+) TTCCAC/TGATTT 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1160448721,2
    		--47199187(+) TTGCAA/GAAGAC 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs767959751,2
    		F,--47199241(+) TTCAAC/TGATTA 1 -- ds50011Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for TNFRSF21 (47199268 - 47277680 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TNFRSF21: --

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFRSF21
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    Disorders / Diseases
    for TNFRSF21 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TNFRSF21 for disorders           About GeneDecksing

    OMIM gene information: 605732    OMIM disorders: --

    10 diseases for TNFRSF21:    About MalaCards
    juvenile myoclonic epilepsy    panic disorder    huntington's disease    hepatitis b
    migraine    leiomyoma    hepatitis    prostatitis
    neuronitis    carcinoma

    3 Novoseek disease relationships for TNFRSF21 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 31.1 7 15019980 (1), 17962943 (1), 15656986 (1), 11455969 (1) (see all 5)
    tumors 13.2 9 17962943 (3), 15019980 (1), 15656986 (1), 11455969 (1)
    cancer 1.01 1 9714541 (1)

    Genetic Association Database (GAD): TNFRSF21
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF21 (5 documents)

    Export disorders for TNFRSF21 gene to outside databases

    Publications
    for TNFRSF21 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFRSF21 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with TNFRSF21)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. (PubMed id 9714541)1, 2, 3, 9 Pan G.... Dixit V.M. (1998)
    2. Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG. (PubMed id 16378686)1, 4 Norberg A....Holmberg M. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Tumor-derived death receptor 6 modulates dendritic cell development. (PubMed id 17962943)1, 9 Derosa D.C....Benschop R.J. (2008)
    8. Functional analysis of the posttranslational modifica tions of the death receptor 6. (PubMed id 19654028)1, 9 KlA-ma M....Andera L. (2009)
    9. S-SAD phasing study of death receptor 6 and its soluti on conformation revealed by SAXS. (PubMed id 22525750)1 Ru H....Liu Z.J. (2012)
    10. Death receptor 6 induces apoptosis not through type I or type II pathways, but via a unique mitochondria-dependent pathway by interact ing with Bax protein. (PubMed id 22761420)1 Zeng L....Xu X. (2012)

    External Searches for TNFRSF21 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TNFRSF21 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27242 HGNC: 13469 AceView: TNFRSF21 Ensembl:ENSG00000146072 euGenes: HUgn27242
    ECgene: TNFRSF21 Kegg: 27242 H-InvDB: TNFRSF21

    Other Databases showing TNFRSF21 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TNFRSF21 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFRSF21 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF21 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TNFRSF21 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TNFRSF21 gene:
    Search GeneIP for patents involving TNFRSF21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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