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TNFRSF21 Gene

protein-coding   GIFtS: 68
GCID: GC06M047246

Tumor Necrosis Factor Receptor Superfamily, Member 21

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 211 2     CD3582
Death Receptor 61 2 3     TNFR-Related Death Receptor 62
DR62 3     Tumor Necrosis Factor Receptor Superfamily Member 212
BM-0182     CD358 Antigen3

External Ids:    HGNC: 134691   Entrez Gene: 272422   Ensembl: ENSG000001460727   OMIM: 6057325   UniProtKB: O755093   

Export aliases for TNFRSF21 gene to outside databases

Previous GC identifers: GC06M047199 GC06M047307 GC06M046922


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFRSF21 Gene:
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates
nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and
induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor
receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor
necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell
activation, and may be involved in inflammation and immune regulation. (provided by RefSeq, Jul 2013)

GeneCards Summary for TNFRSF21 Gene:
TNFRSF21 (tumor necrosis factor receptor superfamily, member 21) is a protein-coding gene. An important paralog of this gene is TNFRSF11A.

UniProtKB/Swiss-Prot: TNR21_HUMAN, O75509
Function: Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote
apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a
role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required
for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface
APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP
(N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies
(via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and
myelination. Plays a role in signaling cascades triggered by stimulation of T cell receptors, in the adaptive
immune response and in the regulation of T cell differentiation and proliferation. Negatively regulates T-cell
responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates
the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T
cell stimulation

Gene Wiki entry for TNFRSF21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFRSF21 gene promoter:
         HFH-3   IRF-1   FOXI1   MZF-1   CREB   Ik-2   deltaCREB   IRF-7A   Meis-1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF21 promoter sequence
   Search Chromatin IP Primers for TNFRSF21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p21.1

TNFRSF21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF21 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M047246:  view genomic region     (about GC identifiers)

Start:
47,199,268 bp from pter      End:
47,277,680 bp from pter
Size:
78,413 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TNR21_HUMAN, O75509 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 21 precursor  
Size: 655 amino acids; 71845 Da
Subunit: Interacts with N-APP (By similarity). Associates with TRADD. Interacts with NGFR
Caution: It is uncertain whether Met-1 or Met-25 is the initiator
Sequence caution: Sequence=AAH10241.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Selected PDB 3D structures from and Proteopedia for TNFRSF21 (see all 7):
2DBH (3D)        3QO4 (3D)        3U3P (3D)        3U3Q (3D)        3U3S (3D)        3U3T (3D)    
Secondary accessions: B2RDI9 Q0D2P5 Q96D86

Explore the universe of human proteins at neXtProt for TNFRSF21: NX_O75509

Explore proteomics data for TNFRSF21 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn82, Asn141, Asn252, Asn257, Asn278, Asn289
  • Modification sites at PhosphoSitePlus

  • See TNFRSF21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055267.1  
    ENSEMBL proteins: 
     ENSP00000296861  
    Reactome Protein details: O75509

    TNFRSF21 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TNFRSF21
    OriGene Custom MassSpec
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    Novus Biologicals TNFRSF21 Proteins
    Novus Biologicals TNFRSF21 Lysates
    Sino Biological Recombinant Protein for TNFRSF21
    Sino Biological Cell Lysate for TNFRSF21
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNFRSF21

     
    Search eBioscience for Proteins for TNFRSF21 

     
    antibodies-online proteins for TNFRSF21 (34 products) 

     
    antibodies-online peptides for TNFRSF21

    TNFRSF21 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Antibodies for TNFRSF21
    OriGene Custom Antibody Services for TNFRSF21
    Novus Biologicals TNFRSF21 Antibodies
    Abcam antibodies for TNFRSF21
    Cloud-Clone Corp. Antibodies for TNFRSF21
    ThermoFisher Antibodies for TNFRSF21
    antibodies-online antibodies for TNFRSF21 (108 products) 

    TNFRSF21 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TNFRSF21
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TNFRSF21
    Cloud-Clone Corp. CLIAs for TNFRSF21
    Search eBioscience for ELISAs for TNFRSF21 
    antibodies-online kits for TNFRSF21 (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: death receptor 6
    Tumour necrosis factor (TNF) receptor family

    4 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR022330 TNFR_21
     IPR011029 DEATH-like_dom
     IPR000488 Death_domain

    Graphical View of Domain Structure for InterPro Entry O75509

    ProtoNet protein and cluster: O75509

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNR21_HUMAN, O75509
    Similarity: Contains 1 death domain
    Similarity: Contains 4 TNFR-Cys repeats


    Find genes that share domains with TNFRSF21           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR21_HUMAN, O75509
    Function: Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote
    apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a
    role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required
    for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface
    APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP
    (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies
    (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and
    myelination. Plays a role in signaling cascades triggered by stimulation of T cell receptors, in the adaptive
    immune response and in the regulation of T cell differentiation and proliferation. Negatively regulates T-cell
    responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates
    the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T
    cell stimulation
    Induction: Up-regulated by TNF

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19225519
         
    Find genes that share ontologies with TNFRSF21           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNFRSF21:
     G0/1 arrest  Increased G1 DNA content 

         7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Tnfrsf21):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     nervous system  no phenotypic analysis 

    Find genes that share phenotypes with TNFRSF21           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TNFRSF21: Tnfrsf21tm1Ddy Tnfrsf21tm1Arte Tnfrsf21tm1Vmd

       genOway: Develop your customized and physiologically relevant rodent model for TNFRSF21

    miRNA
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    miRTarBase miRNAs that target TNFRSF21:
    hsa-mir-93-5p (MIRT028037), hsa-mir-98-5p (MIRT027534), hsa-mir-124-3p (MIRT002620), hsa-mir-130b-3p (MIRT020190), hsa-mir-193b-3p (MIRT016429)

    Block miRNA regulation of human, mouse, rat TNFRSF21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNFRSF21 (see all 18):
    hsa-miR-495 hsa-miR-106a hsa-miR-519a hsa-miR-9 hsa-miR-93 hsa-miR-7-1* hsa-miR-526b* hsa-miR-17
    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF21 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TNFRSF21
    Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF21

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TNFRSF21 (NM_014452)
    Sino Biological Human cDNA Clone for TNFRSF21
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF21

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    ESI BIO PureStem Progenitor for TNFRSF21: 
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNR21_HUMAN, O75509: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol3
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA19654028
    GO:0016021integral component of membrane ----
    GO:0030424axon IEA--

    Find genes that share ontologies with TNFRSF21           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFRSF21 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37


    Find genes that share SuperPaths with TNFRSF21           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFRSF21
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF21 (see all 8)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling
    Apoptosis through Death Receptors

    1 Cell Signaling Technology (CST) Pathway for TNFRSF21
        Apoptosis and Autophagy

    1 GeneGo (Thomson Reuters) Pathway for TNFRSF21
        Apoptosis and survival Apoptotic TNF-family pathways

    1 BioSystems Pathway for TNFRSF21
        Apoptosis

    3 Sino Biological Pathways for TNFRSF21
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    1 Reactome Pathway for TNFRSF21
        PPARA activates gene expression


    1 Kegg Pathway  (Kegg details for TNFRSF21):
        Cytokine-cytokine receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF21: 
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFRSF21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for TNFRSF21 (O755091, 2, 3 ENSP000002968614) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MATR3P432432, 3, ENSP000003543464MINT-8274599 I2D: score=2 STRING: ENSP00000354346
    APPP050671, 3, ENSP000002849814EBI-2313231,EBI-77613 I2D: score=1 STRING: ENSP00000284981
    WASH2PQ6VEQ52, 3MINT-8274621 I2D: score=1 
    STX11O755582, 3, ENSP000003565404MINT-8274610 I2D: score=2 STRING: ENSP00000356540
    TRADDQ156283, ENSP000003412684I2D: score=3 STRING: ENSP00000341268
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001783B cell apoptotic process ISS--
    GO:0002250adaptive immune response ISS--
    GO:0006915apoptotic process IMP--
    GO:0006959humoral immune response ISS--
    GO:0007165signal transduction ----

    Find genes that share ontologies with TNFRSF21           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFRSF21 (TNR21)

    1 Novoseek inferred chemical compound relationship for TNFRSF21 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 13.8 1 15255181 (1)



    Find genes that share compounds with TNFRSF21           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNFRSF21 gene: 
    NM_014452.4  

    Unigene Cluster for TNFRSF21:

    Tumor necrosis factor receptor superfamily, member 21
    Hs.443577  [show with all ESTs]
    Unigene Representative Sequence: AB209394
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000296861(uc003oyv.3)
    miRNA
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    hsa-miR-495 hsa-miR-106a hsa-miR-519a hsa-miR-9 hsa-miR-93 hsa-miR-7-1* hsa-miR-526b* hsa-miR-17
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      QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF21
      QuantiFast Probe-based Assays in human, mouse, rat TNFRSF21

    Additional mRNA sequence: 

    AB209394.1 AF068868.1 AF208860.1 AJ420531.1 AK001504.1 AK025399.1 AK315560.1 AY358304.1 
    BC005192.1 BC010241.1 BC015466.1 BC017730.2 BC021572.1 BT007420.1 CR457190.1 

    8 DOTS entries:

    DT.99977377  DT.213002  DT.99981959  DT.95307093  DT.121364844  DT.121364863  DT.91757160  DT.99953782 

    Selected AceView cDNA sequences (see all 180):

    AA621819 BM977896 BM701729 BM717168 CB850836 BQ233192 CA419857 AA351536 
    AF068868 BI711312 AA993112 AI863142 AA490494 BQ688267 AK025399 BF512756 
    BQ272175 AI926602 NM_014452 BQ575082 AY358304 AA554244 BQ019036 CB266687 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF21    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
    SP1:              -                                       
    SP2:              -                                       
    SP3:                                                      


    ECgene alternative splicing isoforms for TNFRSF21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TNFRSF21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGAAACTT
    TNFRSF21 Expression
    About this image


    TNFRSF21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
             Meninges
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
    TNFRSF21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFRSF21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.443577

    UniProtKB/Swiss-Prot: TNR21_HUMAN, O75509
    Tissue specificity: Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer
    disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and
    prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon,
    spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF21: 
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF21 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf211 , 5 tumor necrosis factor receptor superfamily, member more1, 5 87.41(n)1
    89.14(a)1
      17 (19.69 cM)5
    941851  NM_178589.31  NP_848704.11 
     430165555 
    chicken
    (Gallus gallus)
    Aves TNFRSF211 tumor necrosis factor receptor superfamily, member more 72.73(n)
    74.71(a)
      422062  NM_001031103.1  NP_001026274.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNFRSF216
    tumor necrosis factor receptor superfamily, member...
    69(a)
    1 ↔ 1
    1(138299461-138348807)
    zebrafish
    (Danio rerio)
    Actinopterygii tnfrsf211 tumor necrosis factor receptor superfamily, member more 59.52(n)
    59.52(a)
      564874  NM_001042688.2  NP_001036153.2 


    ENSEMBL Gene Tree for TNFRSF21 (if available)
    TreeFam Gene Tree for TNFRSF21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNFRSF21 gene
    TNFRSF11A2  TNFRSF6B2  LTBR2  TNFRSF11B2  TNFRSF142  CD402  TNFRSF1B2  

    Find genes that share paralogs with TNFRSF21           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFRSF21 (see all 1617)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445960891,2
    --47198841(+) AATAAA/GGACAA 1 -- ds50010--------
    rs1165846241,2
    F--47198878(+) ATCCAA/GAAGAC 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1828247661,2
    --47199005(+) ATTCAC/TTGCAT 1 -- ds50010--------
    rs728619871,2
    --47199013(+) CATGTC/TTCCCT 1 -- ds50010--------
    rs734736101,2
    C,F--47199082(+) TCCTCC/TTTCAG 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1385350141,2
    --47199108(+) GGATGC/TCCTGC 1 -- ds50010--------
    rs728619881,2
    C--47199113(+) CCCTGA/CCTGAA 1 -- ds50010--------
    rs745880591,2
    --47199136(+) TTCCAC/TGATTT 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1160448721,2
    F--47199187(+) TTGCAA/GAAGAC 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs767959751,2
    F--47199241(+) TTCAAC/TGATTA 1 -- ds50011Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for TNFRSF21 (47199268 - 47277680 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TNFRSF21:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv267438CNV Insertion20981092
    nsv885871CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605732    OMIM disorders: --


    Find genes that share disorders with TNFRSF21           About GenesLikeMe

    3 Novoseek inferred disease relationships for TNFRSF21 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 31.1 7 15019980 (1), 17962943 (1), 15656986 (1), 11455969 (1) (see all 5)
    tumors 13.2 9 17962943 (3), 15019980 (1), 15656986 (1), 11455969 (1)
    cancer 1.01 1 9714541 (1)

    Genetic Association Database (GAD): TNFRSF21
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF21 (5 documents)

    Export disorders for TNFRSF21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFRSF21 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with TNFRSF21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. (PubMed id 9714541)1, 2, 3, 9 Pan G.... Dixit V.M. (FEBS Lett. 1998)
    2. Functional analysis of the posttranslational modifications of the death receptor 6. (PubMed id 19654028)1, 2, 9 KlA-ma M....Andera L. (Biochim. Biophys. Acta 2009)
    3. S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS. (PubMed id 22525750)1, 2 Ru H....Liu Z.J. (Acta Crystallogr. D Biol. Crystallogr. 2012)
    4. Death receptor 6 induces apoptosis not through type I or type II pathways, but via a unique mitochondria-dependent pathway by interacting with Bax protein. (PubMed id 22761420)1, 2 Zeng L....Xu X. (J. Biol. Chem. 2012)
    5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    6. Genome-wide association study of panic disorder in the Japanese population. (PubMed id 19165232)1, 4 Otowa T....Okazaki Y. (J. Hum. Genet. 2009)
    7. Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG. (PubMed id 16378686)1, 4 Norberg A....Holmberg M. (Neurosci. Lett. 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PubMed id 15301860)1, 4 Cho S.M....Lee J.K. (Hum. Immunol. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27242 HGNC: 13469 AceView: TNFRSF21 Ensembl:ENSG00000146072 euGenes: HUgn27242
    ECgene: TNFRSF21 Kegg: 27242 H-InvDB: TNFRSF21

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNFRSF21 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF21 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFRSF21 gene:
    Search GeneIP for patents involving TNFRSF21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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