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Aliases for TNFRSF21 Gene

Aliases for TNFRSF21 Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 21 2 3
  • Death Receptor 6 2 3 4
  • DR6 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 21 3
  • TNFR-Related Death Receptor 6 3
  • CD358 Antigen 4
  • BM-018 3
  • CD358 3

External Ids for TNFRSF21 Gene

Previous GeneCards Identifiers for TNFRSF21 Gene

  • GC06M047199
  • GC06M047246
  • GC06M046922

Summaries for TNFRSF21 Gene

Entrez Gene Summary for TNFRSF21 Gene

  • This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]

GeneCards Summary for TNFRSF21 Gene

TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21) is a Protein Coding gene. Among its related pathways are Akt Signaling and Akt Signaling. An important paralog of this gene is TNFRSF14.

UniProtKB/Swiss-Prot for TNFRSF21 Gene

  • Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.

Gene Wiki entry for TNFRSF21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF21 Gene

Genomics for TNFRSF21 Gene

Regulatory Elements for TNFRSF21 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNFRSF21 Gene

Start:
47,231,527 bp from pter
End:
47,309,947 bp from pter
Size:
78,421 bases
Orientation:
Minus strand

Genomic View for TNFRSF21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF21 Gene

Proteins for TNFRSF21 Gene

  • Protein details for TNFRSF21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75509-TNR21_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 21
    Protein Accession:
    O75509
    Secondary Accessions:
    • B2RDI9
    • Q0D2P5
    • Q96D86

    Protein attributes for TNFRSF21 Gene

    Size:
    655 amino acids
    Molecular mass:
    71845 Da
    Quaternary structure:
    • Interacts with N-APP (By similarity). Associates with TRADD. Interacts with NGFR.
    SequenceCaution:
    • Sequence=AAH10241.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNFRSF21 Gene

neXtProt entry for TNFRSF21 Gene

Proteomics data for TNFRSF21 Gene at MOPED

Post-translational modifications for TNFRSF21 Gene

  • Glycosylation at Asn82, Asn141, Asn252, Asn257, Asn278, and Asn289
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF21 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFRSF21 (DR6/TNFRSF21)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF21 (DR6)

Protein Products

  • Enzo Life Sciences proteins for TNFRSF21
  • Cloud-Clone Corp. Proteins for TNFRSF21

No data available for DME Specific Peptides for TNFRSF21 Gene

Domains for TNFRSF21 Gene

Gene Families for TNFRSF21 Gene

HGNC:
  • CD :CD molecules
  • TNFRSF :Tumor necrosis factor receptor superfamily
IUPHAR :

Protein Domains for TNFRSF21 Gene

Suggested Antigen Peptide Sequences for TNFRSF21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75509

UniProtKB/Swiss-Prot:

TNR21_HUMAN :
  • O75509
Domain:
  • Contains 1 death domain.
Similarity:
  • Contains 4 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF21: view

Function for TNFRSF21 Gene

Molecular function for TNFRSF21 Gene

UniProtKB/Swiss-Prot Function: Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.
UniProtKB/Swiss-Prot Induction: Up-regulated by TNF.

Gene Ontology (GO) - Molecular Function for TNFRSF21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19225519
genes like me logo Genes that share ontologies with TNFRSF21: view
genes like me logo Genes that share phenotypes with TNFRSF21: view

Animal Models for TNFRSF21 Gene

MGI Knock Outs for TNFRSF21:

Animal Model Products

CRISPR Products

miRNA for TNFRSF21 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF21

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TNFRSF21 Gene

Localization for TNFRSF21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF21 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFRSF21 Gene COMPARTMENTS Subcellular localization image for TNFRSF21 gene
Compartment Confidence
plasma membrane 4
cytosol 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TNFRSF21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 19654028
GO:0030424 axon IEA --
GO:0031226 intrinsic component of plasma membrane ISS --
genes like me logo Genes that share ontologies with TNFRSF21: view

Pathways for TNFRSF21 Gene

genes like me logo Genes that share pathways with TNFRSF21: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TNFRSF21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001783 B cell apoptotic process ISS --
GO:0002250 adaptive immune response ISS --
GO:0006915 apoptotic process IMP 22761420
GO:0006959 humoral immune response ISS --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with TNFRSF21: view

Compounds for TNFRSF21 Gene

(1) Novoseek inferred chemical compound relationships for TNFRSF21 Gene

Compound -log(P) Hits PubMed IDs
serine 13.8 1
genes like me logo Genes that share compounds with TNFRSF21: view

Transcripts for TNFRSF21 Gene

mRNA/cDNA for TNFRSF21 Gene

(180) Selected AceView cDNA sequences:
(15) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFRSF21 Gene

Tumor necrosis factor receptor superfamily, member 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF21

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF21 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: -
SP3:

Relevant External Links for TNFRSF21 Gene

GeneLoc Exon Structure for
TNFRSF21
ECgene alternative splicing isoforms for
TNFRSF21

Expression for TNFRSF21 Gene

mRNA expression in normal human tissues for TNFRSF21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF21 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNFRSF21 Gene

SOURCE GeneReport for Unigene cluster for TNFRSF21 Gene Hs.443577

mRNA Expression by UniProt/SwissProt for TNFRSF21 Gene

O75509-TNR21_HUMAN
Tissue specificity: Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
genes like me logo Genes that share expressions with TNFRSF21: view

In Situ Assay Products

Orthologs for TNFRSF21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF21 35
  • 99.59 (n)
  • 99.39 (a)
TNFRSF21 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNFRSF21 35
  • 89.37 (n)
  • 90.95 (a)
TNFRSF21 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
TNFRSF21 35
  • 90.62 (n)
  • 92.58 (a)
mouse
(Mus musculus)
Mammalia Tnfrsf21 35
  • 87.41 (n)
  • 89.14 (a)
Tnfrsf21 16
Tnfrsf21 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNFRSF21 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFRSF21 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfrsf21 35
  • 87.51 (n)
  • 89.3 (a)
chicken
(Gallus gallus)
Aves TNFRSF21 35
  • 72.73 (n)
  • 74.71 (a)
TNFRSF21 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFRSF21 36
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tnfrsf21 35
  • 59.52 (n)
  • 59.52 (a)
tnfrsf21 36
  • 54 (a)
OneToOne
Species with no ortholog for TNFRSF21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF21 Gene

ENSEMBL:
Gene Tree for TNFRSF21 (if available)
TreeFam:
Gene Tree for TNFRSF21 (if available)

Paralogs for TNFRSF21 Gene

Paralogs for TNFRSF21 Gene

genes like me logo Genes that share paralogs with TNFRSF21: view

Variants for TNFRSF21 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF21 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs714373 -- 47,261,890(-) ATACA(A/G)ATTTT intron-variant
rs910554 -- 47,236,021(-) AGCCA(C/T)AGTCA intron-variant
rs993612 -- 47,276,062(-) ATCTC(A/G)TCTTT intron-variant
rs1048689 -- 47,231,675(-) ACCTT(C/T)TAATG utr-variant-3-prime
rs1057415 -- 47,309,650(-) GGCCG(C/T)AGCAG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF21 Gene

Variant ID Type Subtype PubMed ID
nsv885871 CNV Gain 21882294
esv267438 CNV Insertion 20981092

Relevant External Links for TNFRSF21 Gene

HapMap Linkage Disequilibrium report
TNFRSF21
Human Gene Mutation Database (HGMD)
TNFRSF21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF21 Gene

Disorders for TNFRSF21 Gene

(3) Novoseek inferred disease relationships for TNFRSF21 Gene

Disease -log(P) Hits PubMed IDs
necrosis 31.1 5
tumors 13.2 6
cancer 1.01 1

Relevant External Links for TNFRSF21

Genetic Association Database (GAD)
TNFRSF21
Human Genome Epidemiology (HuGE) Navigator
TNFRSF21
genes like me logo Genes that share disorders with TNFRSF21: view

No data available for UniProtKB/Swiss-Prot for TNFRSF21 Gene

Publications for TNFRSF21 Gene

  1. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. (PMID: 9714541) Pan G. … Dixit V.M. (FEBS Lett. 1998) 2 3 4 23
  2. Functional analysis of the posttranslational modifications of the death receptor 6. (PMID: 19654028) KlA-ma M. … Andera L. (Biochim. Biophys. Acta 2009) 3 4 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TNFRSF21 Gene

Sources for TNFRSF21 Gene

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