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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF21 Gene

protein-coding   GIFtS: 68
GCID: GC06M047246

Tumor Necrosis Factor Receptor Superfamily, Member 21

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 211 2     CD3582
Death Receptor 61 2 3     TNFR-Related Death Receptor 62
DR62 3     Tumor Necrosis Factor Receptor Superfamily Member 212
BM-0182     CD358 Antigen3

External Ids:    HGNC: 134691   Entrez Gene: 272422   Ensembl: ENSG000001460727   OMIM: 6057325   UniProtKB: O755093   

Export aliases for TNFRSF21 gene to outside databases

Previous GC identifers: GC06M047199 GC06M047307 GC06M046922


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF21 Gene:
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates
nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and
induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor
receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor
necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell
activation, and may be involved in inflammation and immune regulation. (provided by RefSeq, Jul 2013)

GeneCards Summary for TNFRSF21 Gene: 
TNFRSF21 (tumor necrosis factor receptor superfamily, member 21) is a protein-coding gene. Diseases associated with TNFRSF21 include juvenile myoclonic epilepsy, and panic disorder, and among its related super-pathways are TNF Signaling and STAT3 Pathway. GO annotations related to this gene include protein binding. An important paralog of this gene is TNFRSF11A.

UniProtKB/Swiss-Prot: TNR21_HUMAN, O75509
Function: May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell
differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers
the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an
N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both
neuronal cell bodies (via caspase-3) and axons (via caspase-6)

Gene Wiki entry for TNFRSF21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF21 gene promoter:
         HFH-3   IRF-1   FOXI1   MZF-1   CREB   Ik-2   deltaCREB   IRF-7A   Meis-1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF21 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p21.1

TNFRSF21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF21 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M047246:  view genomic region     (about GC identifiers)

Start:
47,199,268 bp from pter      End:
47,277,680 bp from pter
Size:
78,413 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNR21_HUMAN, O75509 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 21 precursor  
Size: 655 amino acids; 71845 Da
Subunit: Associates with TRADD. Interacts with N-APP (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein (Probable)
Caution: It is uncertain whether Met-1 or Met-25 is the initiator
Sequence caution: Sequence=AAH10241.1; Type=Erroneous initiation;
6/7 PDB 3D structures from and Proteopedia for TNFRSF21 (see all 7):
2DBH (3D)        3QO4 (3D)        3U3P (3D)        3U3Q (3D)        3U3S (3D)        3U3T (3D)    
Secondary accessions: B2RDI9 Q0D2P5 Q96D86

Explore the universe of human proteins at neXtProt for TNFRSF21: NX_O75509

Explore proteomics data for TNFRSF21 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75509

  • TNFRSF21 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNFRSF21 Protein Expression
    REFSEQ proteins: NP_055267.1  
    ENSEMBL proteins: 
     ENSP00000296861  
    Reactome Protein details: O75509
    Human Recombinant Protein Products for TNFRSF21: 
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    Sino Biological Recombinant Protein for TNFRSF21
    Sino Biological Cell Lysate for TNFRSF21 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNFRSF21 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0030424axon IEA--

    TNFRSF21 for ontologies           About GeneDecksing



    TNFRSF21 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: death receptor 6 
    Tumour necrosis factor (TNF) receptor family

    4 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR022330 TNFR_21
     IPR011029 DEATH-like_dom
     IPR000488 Death_domain

    Graphical View of Domain Structure for InterPro Entry O75509

    ProtoNet protein and cluster: O75509

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNR21_HUMAN, O75509
    Similarity: Contains 1 death domain
    Similarity: Contains 4 TNFR-Cys repeats


    TNFRSF21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR21_HUMAN, O75509
    Function: May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell
    differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers
    the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an
    N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both
    neuronal cell bodies (via caspase-3) and axons (via caspase-6)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19225519
         
    TNFRSF21 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNFRSF21:
     G0/1 arrest  Increased G1 DNA content 

         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tnfrsf21):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     nervous system  no phenotypic analysis 

    TNFRSF21 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TNFRSF21: Tnfrsf21tm1Ddy Tnfrsf21tm1Vmd

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNFRSF21 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNFRSF21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF21 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF21 

    miRNA
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    hsa-miR-495 hsa-miR-106a hsa-miR-519a hsa-miR-9 hsa-miR-93 hsa-miR-7-1* hsa-miR-526b* hsa-miR-17
    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF21 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TNFRSF21 (NM_014452)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF21
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                         Customized lentivirus expression plasmids for stable overexpression of TNFRSF21 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF21


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNFRSF21 About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.74
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    PPARA Activates Gene Expression0.74
    5Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TNFRSF21
        Apoptosis and survival Apoptotic TNF-family pathways

    1 R&D Systems Pathway for TNFRSF21
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF21 (see all 8)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling
    Apoptosis through Death Receptors

    1 Cell Signaling Technology (CST) Pathway for TNFRSF21
        Apoptosis and Autophagy

    1 GeneGo (Thomson Reuters) Pathway for TNFRSF21
        Apoptosis and survival Apoptotic TNF-family pathways

    1 BioSystems Pathway for TNFRSF21
        Apoptosis

    3 Sino Biological Pathways for TNFRSF21 
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    5        Reactome Pathways for TNFRSF21
        Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Metabolism
    PPARA Activates Gene Expression
    Fatty acid, triacylglycerol, and ketone body metabolism
    Metabolism of lipids and lipoproteins


    1         Kegg Pathway  (Kegg details for TNFRSF21):
        Cytokine-cytokine receptor interaction


    TNFRSF21 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/17 Interacting proteins for TNFRSF21 (O755091, 2, 3 ENSP000002968614) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MATR3P432432, 3, ENSP000003543464MINT-8274599 I2D: score=2 STRING: ENSP00000354346
    APPP050671, 3, ENSP000002849814EBI-2313231,EBI-77613 I2D: score=1 STRING: ENSP00000284981
    WASH2PQ6VEQ52, 3MINT-8274621 I2D: score=1 
    STX11O755582, 3, ENSP000003565404MINT-8274610 I2D: score=2 STRING: ENSP00000356540
    TRADDQ156283, ENSP000003412684I2D: score=3 STRING: ENSP00000341268
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0044255cellular lipid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0051402neuron apoptotic process IEA--

    TNFRSF21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNFRSF21 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFRSF21 (TNR21)

    1 Novoseek inferred chemical compound relationship for TNFRSF21 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 13.8 1 15255181 (1)

    Search CenterWatch for drugs/clinical trials and news about TNFRSF21 / TNR21

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNFRSF21 gene: 
    NM_014452.4  

    Unigene Cluster for TNFRSF21:

    Tumor necrosis factor receptor superfamily, member 21
    Hs.443577  [show with all ESTs]
    Unigene Representative Sequence: AB209394
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000296861(uc003oyv.3)
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    Additional mRNA sequence: 

    AB209394.1 AF068868.1 AF208860.1 AJ420531.1 AK001504.1 AK025399.1 AK315560.1 AY358304.1 
    BC005192.1 BC010241.1 BC015466.1 BC017730.2 BC021572.1 BT007420.1 CR457190.1 

    8 DOTS entries:

    DT.99977377  DT.213002  DT.99981959  DT.95307093  DT.121364844  DT.121364863  DT.91757160  DT.99953782 

    24/180 AceView cDNA sequences (see all 180):

    BC017730 BM717168 AA351536 BQ575082 BQ272175 AY358304 AF068868 AA554244 
    AI926602 NM_014452 CA454584 AW170605 BQ688267 AA490494 AA621819 AI863142 
    AA555059 CB266687 AK025399 CB850836 BQ233192 BQ019036 AA993112 BM977896 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF21    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
    SP1:              -                                       
    SP2:              -                                       
    SP3:                                                      


    ECgene alternative splicing isoforms for TNFRSF21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFRSF21 expression in normal human tissues (normalized intensities)      TNFRSF21 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGAAACTT
    TNFRSF21 Expression
    About this image


    TNFRSF21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 5 entries
             PureStem Progenitor W10
     
     Endothelium (Cardiovascular System)    fully expand to see all 4 entries
             Adult Endothelial Cells Blood Brain Barrier
             Peripheral blood-derived endothelial progenitor cells
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             visceral organ/lung/right lung   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
             Meninges
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose/nasal cavity   

    See TNFRSF21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFRSF21

    SOURCE GeneReport for Unigene cluster: Hs.443577

    UniProtKB/Swiss-Prot: TNR21_HUMAN, O75509
    Tissue specificity: Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate.
    Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone
    marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF21: 
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF21
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF21 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf211 , 5 tumor necrosis factor receptor superfamily, member more1, 5 87.41(n)1
    89.14(a)1
      17 (19.69 cM)5
    941851  NM_178589.31  NP_848704.11 
     430165555 
    chicken
    (Gallus gallus)
    Aves TNFRSF211 tumor necrosis factor receptor superfamily, member more 73.12(n)
    75.48(a)
      422062  NM_001031103.1  NP_001026274.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNFRSF216
    tumor necrosis factor receptor superfamily, member...
    68(a)
    1 ↔ 1
    1(138299461-138348807)
    zebrafish
    (Danio rerio)
    Actinopterygii tnfrsf211 tumor necrosis factor receptor superfamily, member more 60.61(n)
    61.42(a)
      564874  NM_001042688.2  NP_001036153.2 


    ENSEMBL Gene Tree for TNFRSF21 (if available)
    TreeFam Gene Tree for TNFRSF21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFRSF21 gene
    TNFRSF11A2  TNFRSF6B2  LTBR2  TNFRSF11B2  TNFRSF142  CD402  TNFRSF1B2  

    TNFRSF21 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1617 SNPs in TNFRSF21 are shown (see all 1617)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445960891,2
    --47198841(+) AATAAA/GGACAA 1 -- ds50010--------
    rs1165846241,2
    F--47198878(+) ATCCAA/GAAGAC 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1828247661,2
    --47199005(+) ATTCAC/TTGCAT 1 -- ds50010--------
    rs728619871,2
    --47199013(+) CATGTC/TTCCCT 1 -- ds50010--------
    rs734736101,2
    C,F--47199082(+) TCCTCC/TTTCAG 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1385350141,2
    --47199108(+) GGATGC/TCCTGC 1 -- ds50010--------
    rs728619881,2
    C--47199113(+) CCCTGA/CCTGAA 1 -- ds50010--------
    rs745880591,2
    --47199136(+) TTCCAC/TGATTT 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1160448721,2
    F--47199187(+) TTGCAA/GAAGAC 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs767959751,2
    F--47199241(+) TTCAAC/TGATTA 1 -- ds50011Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for TNFRSF21 (47199268 - 47277680 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TNFRSF21:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv267438CNV Insertion20981092
    nsv885871CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605732    OMIM disorders: --

    9 diseases for TNFRSF21:    About MalaCards
    juvenile myoclonic epilepsy    panic disorder    migraine    leiomyoma
    hepatitis b    sarcoma    hepatitis    prostatitis
    neuronitis


    TNFRSF21 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TNFRSF21 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 31.1 7 15019980 (1), 17962943 (1), 15656986 (1), 11455969 (1) (see all 5)
    tumors 13.2 9 17962943 (3), 15019980 (1), 15656986 (1), 11455969 (1)
    cancer 1.01 1 9714541 (1)

    Genetic Association Database (GAD): TNFRSF21
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF21 (5 documents)

    Export disorders for TNFRSF21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFRSF21 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with TNFRSF21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. (PubMed id 9714541)1, 2, 3, 9 Pan G.... Dixit V.M. (1998)
    2. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    3. Genome-wide association study of panic disorder in the Japanese population. (PubMed id 19165232)1, 4 Otowa T....Okazaki Y. (2009)
    4. Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG. (PubMed id 16378686)1, 4 Norberg A....Holmberg M. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PubMed id 15301860)1, 4 Cho S.M....Lee J.K. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    10. Tumor-derived death receptor 6 modulates dendritic cell development. (PubMed id 17962943)1, 9 Derosa D.C....Benschop R.J. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27242 HGNC: 13469 AceView: TNFRSF21 Ensembl:ENSG00000146072 euGenes: HUgn27242
    ECgene: TNFRSF21 Kegg: 27242 H-InvDB: TNFRSF21

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFRSF21 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF21 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNFRSF21 gene:
    Search GeneIP for patents involving TNFRSF21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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