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Aliases for TNFRSF21 Gene

Aliases for TNFRSF21 Gene

  • TNF Receptor Superfamily Member 21 2 3 5
  • Death Receptor 6 2 3 4
  • DR6 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 21 2
  • Tumor Necrosis Factor Receptor Superfamily Member 21 3
  • TNFR-Related Death Receptor 6 3
  • CD358 Antigen 4
  • BM-018 3
  • CD358 3

External Ids for TNFRSF21 Gene

Previous GeneCards Identifiers for TNFRSF21 Gene

  • GC06M047199
  • GC06M047246
  • GC06M046922

Summaries for TNFRSF21 Gene

Entrez Gene Summary for TNFRSF21 Gene

  • This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]

GeneCards Summary for TNFRSF21 Gene

TNFRSF21 (TNF Receptor Superfamily Member 21) is a Protein Coding gene. Diseases associated with TNFRSF21 include Diffuse Infiltrative Lymphocytosis Syndrome and Alzheimer Disease. Among its related pathways are Akt Signaling and Metabolism. An important paralog of this gene is TNFRSF1B.

UniProtKB/Swiss-Prot for TNFRSF21 Gene

  • Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.

Gene Wiki entry for TNFRSF21 Gene

Additional gene information for TNFRSF21 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF21 Gene

Genomics for TNFRSF21 Gene

GeneHancer (GH) Regulatory Elements for TNFRSF21 Gene

Promoters and enhancers for TNFRSF21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I047307 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.9 873 2.9 HDGF FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 TNFRSF21 SLC25A27 TDRD6 LOC105375081
GH06I047046 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.8 +262.4 262369 1.6 ATF1 CLOCK FOXA2 ARID4B SIN3A FEZF1 ZNF2 YY1 GATA2 ZNF143 TNFRSF21 ADGRF5 PLA2G7 ADGRF1 LOC105375081
GH06I047245 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.1 +62.3 62312 3.3 THRB CHAMP1 ZNF766 EGR2 SMAD5 RXRA NCOA1 CEBPB ELF1 ZNF592 TNFRSF21 LOC105375081
GH06I047061 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.9 +248.1 248071 1.1 ELF3 SOX13 TFAP4 ESRRA SAP130 ZNF644 KMT2B RAD21 RARA NR2F6 TNFRSF21 ADGRF1 LOC105375081
GH06I047096 Enhancer 1.1 Ensembl ENCODE 11.7 +212.1 212095 3.5 MLX ARID4B ARID2 ZNF143 RUNX3 DEK NCOA1 REST KAT8 NFIL3 TNFRSF21 LOC105375081 ADGRF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFRSF21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFRSF21 gene promoter:

Genomic Locations for TNFRSF21 Gene

Genomic Locations for TNFRSF21 Gene
chr6:47,231,527-47,309,976
(GRCh38/hg38)
Size:
78,450 bases
Orientation:
Minus strand
chr6:47,199,268-47,277,680
(GRCh37/hg19)

Genomic View for TNFRSF21 Gene

Genes around TNFRSF21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF21 Gene

Proteins for TNFRSF21 Gene

  • Protein details for TNFRSF21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75509-TNR21_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 21
    Protein Accession:
    O75509
    Secondary Accessions:
    • B2RDI9
    • Q0D2P5
    • Q96D86

    Protein attributes for TNFRSF21 Gene

    Size:
    655 amino acids
    Molecular mass:
    71845 Da
    Quaternary structure:
    • Interacts with N-APP (By similarity). Associates with TRADD. Interacts with NGFR.
    SequenceCaution:
    • Sequence=AAH10241.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNFRSF21 Gene

neXtProt entry for TNFRSF21 Gene

Post-translational modifications for TNFRSF21 Gene

  • Glycosylation at isoforms=82, isoforms=141, isoforms=252, isoforms=257, posLast=278278, and posLast=289289

Other Protein References for TNFRSF21 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFRSF21 (DR6/TNFRSF21)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF21 (DR6)
  • Abcam antibodies for TNFRSF21
  • Santa Cruz Biotechnology (SCBT) Antibodies for TNFRSF21

No data available for DME Specific Peptides for TNFRSF21 Gene

Domains & Families for TNFRSF21 Gene

Gene Families for TNFRSF21 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TNFRSF21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFRSF21: view

No data available for UniProtKB/Swiss-Prot for TNFRSF21 Gene

Function for TNFRSF21 Gene

Molecular function for TNFRSF21 Gene

UniProtKB/Swiss-Prot Function:
Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.
UniProtKB/Swiss-Prot Induction:
Up-regulated by TNF.

Phenotypes From GWAS Catalog for TNFRSF21 Gene

Gene Ontology (GO) - Molecular Function for TNFRSF21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005031 tumor necrosis factor-activated receptor activity IBA --
genes like me logo Genes that share ontologies with TNFRSF21: view
genes like me logo Genes that share phenotypes with TNFRSF21: view

Animal Models for TNFRSF21 Gene

MGI Knock Outs for TNFRSF21:

Animal Model Products

Clone Products

Cell Line Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF21 Gene

Localization for TNFRSF21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF21 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF21 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 3
extracellular 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TNFRSF21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 19654028
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with TNFRSF21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFRSF21 Gene

Pathways & Interactions for TNFRSF21 Gene

genes like me logo Genes that share pathways with TNFRSF21: view

SIGNOR curated interactions for TNFRSF21 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TNFRSF21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001783 B cell apoptotic process ISS --
GO:0002250 adaptive immune response ISS --
GO:0002376 immune system process IEA --
GO:0006915 apoptotic process IMP 22761420
GO:0006954 inflammatory response IBA --
genes like me logo Genes that share ontologies with TNFRSF21: view

Drugs & Compounds for TNFRSF21 Gene

(1) Drugs for TNFRSF21 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TNFRSF21: view

Transcripts for TNFRSF21 Gene

mRNA/cDNA for TNFRSF21 Gene

Unigene Clusters for TNFRSF21 Gene

Tumor necrosis factor receptor superfamily, member 21:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF21 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: -
SP3:

Relevant External Links for TNFRSF21 Gene

GeneLoc Exon Structure for
TNFRSF21
ECgene alternative splicing isoforms for
TNFRSF21

Expression for TNFRSF21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF21 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.0).

Protein differential expression in normal tissues from HIPED for TNFRSF21 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNFRSF21 Gene



Protein tissue co-expression partners for TNFRSF21 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF21 Gene:

TNFRSF21

SOURCE GeneReport for Unigene cluster for TNFRSF21 Gene:

Hs.443577

mRNA Expression by UniProt/SwissProt for TNFRSF21 Gene:

O75509-TNR21_HUMAN
Tissue specificity: Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for TNFRSF21 Gene

  • Nervous system(4.9)
  • Eye(4.2)
  • Intestine(4.2)
  • Blood(3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with TNFRSF21: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF21 Gene

Orthologs for TNFRSF21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF21 34 33
  • 99.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 95 (a)
OneToMany
TNFRSF21 33
  • 90.62 (n)
-- 34
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TNFRSF21 34 33
  • 89.37 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfrsf21 33
  • 87.51 (n)
mouse
(Mus musculus)
Mammalia Tnfrsf21 34 16 33
  • 87.41 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNFRSF21 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFRSF21 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNFRSF21 34 33
  • 72.73 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFRSF21 34
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tnfrsf21 34 33
  • 59.52 (n)
OneToOne
Species where no ortholog for TNFRSF21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF21 Gene

ENSEMBL:
Gene Tree for TNFRSF21 (if available)
TreeFam:
Gene Tree for TNFRSF21 (if available)

Paralogs for TNFRSF21 Gene

Paralogs for TNFRSF21 Gene

genes like me logo Genes that share paralogs with TNFRSF21: view

Variants for TNFRSF21 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF21 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000006354 -- 47,245,969(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000036567 -- 47,260,895(-) T/A genic_downstream_transcript_variant, intron_variant
rs1000088474 -- 47,261,098(-) C/G genic_downstream_transcript_variant, intron_variant
rs1000104077 -- 47,301,148(-) T/A intron_variant
rs1000161358 -- 47,243,200(-) C/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF21 Gene

Variant ID Type Subtype PubMed ID
nsv1017113 CNV gain 25217958

Variation tolerance for TNFRSF21 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFRSF21 Gene

Human Gene Mutation Database (HGMD)
TNFRSF21
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF21 Gene

Disorders for TNFRSF21 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TNFRSF21 Gene - From: HGMD, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFRSF21

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNFRSF21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF21 Gene

Publications for TNFRSF21 Gene

  1. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. (PMID: 9714541) Pan G … Dixit VM (FEBS letters 1998) 2 3 4 22 58
  2. Functional analysis of the posttranslational modifications of the death receptor 6. (PMID: 19654028) Klíma M … Andera L (Biochimica et biophysica acta 2009) 3 4 22 58
  3. S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS. (PMID: 22525750) Ru H … Liu ZJ (Acta crystallographica. Section D, Biological crystallography 2012) 3 4 58
  4. Death receptor 6 induces apoptosis not through type I or type II pathways, but via a unique mitochondria-dependent pathway by interacting with Bax protein. (PMID: 22761420) Zeng L … Xu X (The Journal of biological chemistry 2012) 3 4 58
  5. Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination. (PMID: 21725297) Mi S … Pepinsky RB (Nature medicine 2011) 3 4 58

Products for TNFRSF21 Gene

Sources for TNFRSF21 Gene

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