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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TNFRSF1B Gene

protein-coding GIFtS: 71
GCID: GC01P012161

tumor necrosis factor receptor superfamily, member 1B

(Previous symbol: TNFR2)

Explore 197 diseases affiliated with
TNFRSF1B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 1B¹ ²		P80 TNF-Alpha Receptor² ³
TNFBR¹ ² ³ ⁵		TBPII²
TNFR2¹ ² ³ ⁵		TNFR1B²
P75¹		P75 TNF Receptor²
CD120b¹ ²		P75TNFR¹
TNF-R-II¹ ²		Soluble TNFR1B Variant 1²
TNF-R75¹ ²		Tumor Necrosis Factor Beta Receptor²
TNFR80¹ ²		Tumor Necrosis Factor Binding Protein 2²
Tumor Necrosis Factor Receptor 2² ³		Tumor Necrosis Factor Receptor Superfamily Member 1B²
Tumor Necrosis Factor Receptor Type II² ³		Etanercept³
TNF-R2² ³		TNFR-II³
TNF-RII² ³		CD120b Antigen³

External Ids:	HGNC: 11917¹	Entrez Gene: 7133²	Ensembl: ENSG00000028137⁷	OMIM: 191191⁵	UniProtKB: P20333³

Export aliases for TNFRSF1B gene to outside databases

Previous GC identifers: GC01P012291 GC01P012071 GC01P011836 GC01P011936 GC01P011380

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF1B:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a

heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3

ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to

potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which

mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons

from apoptosis by stimulating antioxidative pathways. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333

Function: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric

TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to

TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced

apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity

Gene Wiki entry for TNFRSF1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_021937.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNFRSF1B gene promoter:
AML1a STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNFRSF1B promoter sequence

Search SABiosciences Chromatin IP Primers for TNFRSF1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.22

TNFRSF1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF1B gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P012161: view genomic region (about GC identifiers)

Start:	12,227,060 bp from pter	End:	12,269,285 bp from pter
Size:	42,226 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 1B precursor

Size: 461 amino acids; 48291 Da

Subunit: Binds to TRAF2. Interacts with BMX

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

Subcellular location: Tumor necrosis factor-binding protein 2: Secreted

2 PDB 3D structures from and Proteopedia for TNFRSF1B:

1CA9 (3D)

3ALQ (3D)

Secondary accessions: B1AJZ3 Q16042 Q6YI29 Q9UIH1

Alternative splicing: 2 isoforms: P20333-1 P20333-2

Explore the universe of human proteins at neXtProt for TNFRSF1B: NX_P20333

Post-translational modifications:

Phosphorylated; mainly on serine residues and with a very low level on threonine residues¹

A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20333

TNFRSF1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001057.1

ENSEMBL proteins:

ENSP00000365435 ENSP00000440425

Human Recombinant Protein Products:

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	Novus Biologicals TNFRSF1B Proteins Novus Biologicals TNFRSF1B Lysates
	Sino Biological Recombinant Protein for TNFRSF1B
	ProSpec Recombinant Protein for TNFRSF1B
	Uscn Proteins for TNFRSF1B

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--

TNFRSF1B for ontologies About GeneDecksing

TNFRSF1B Antibody Products:

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	Uscn Antibodies for TNFRSF1B
	ThermoFisher Antibodies for TNFRSF1B

Assay Products for TNFRSF1B:

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	GenScript Custom Assay Services for TNFRSF1B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TNFRSF1B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNFRSF1B for domains About GeneDecksing

2 InterPro domains/families:

IPR001368 TNFR/NGFR_Cys_rich_reg

IPR020411 TNFR_1B

Graphical View of Domain Structure for InterPro Entry P20333

ProtoNet protein and cluster: P20333

1 Blocks protein family: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333

Similarity: Contains 4 TNFR-Cys repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333

Function: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric

TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to

TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced

apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity

Genatlas biochemistry entry for TNFRSF1B:

tumor necrosis factor receptor superfamily,member 1B,deleted in neuroblastoma,associated with susceptibility to

systemic lupus erythematosus

miRNA Products:		OriGene 3'-UTR Clone: TNFRSF1B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFRSF1B
		8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFRSF1B (see all 37):
		hsa-miR-3938 hsa-let-7d hsa-miR-301a hsa-miR-486-3p hsa-let-7g hsa-let-7a hsa-miR-130b hsa-miR-301b

		SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF1B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFRSF1B (see all 7) OriGene shRNA RFP: TNFRSF1B OriGene siRNA: TNFRSF1B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFRSF1B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TNFRSF1B

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF1B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF1B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TNFRSF1B (NM_001066)
		Sino Biological Human cDNA Clone for TNFRSF1B
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF1B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TNFRSF1B
		Search LifeMap BioReagents cell lines for TNFRSF1B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF1B

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005031	tumor necrosis factor-activated receptor activity	IEA	--
GO:0005515	protein binding	IPI	10848577
GO:0031625	ubiquitin protein ligase binding	IPI	11279055

TNFRSF1B for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TNFRSF1B:

Decreased Hepatitis C virus re

Animal Models:
Mouse knock-outs for TNFRSF1B: Tnfrsf1b^tm1Imx Tnfrsf1b^tm1Mwm
15/19 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tnfrsf1b) (see all 19):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	immune system	integument
liver/biliary system	mortality/aging	muscle	nervous system	renal/urinary system

TNFRSF1B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway	1.00			Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway	0.46
	Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway	1.00			Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway	0.46

TGF-Beta Pathway

	TGF-Beta Pathway	1.00			JAK-STAT Pathway	0.57
	MAPK Family Pathway	0.60			JNK Pathway	0.50

PEDF Induced Signaling

	STAT3 Pathway	0.47			Glucocorticoid Receptor Signaling	0.27
	PGC1Alpha Pathway	0.33			Cytokine-cytokine receptor interaction	0.26

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

TRAF Pathway

	TRAF Pathway	1.00			TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions	0.08
	TNF Superfamily Pathway	0.42

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for TNFRSF1B

	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
	Apoptosis and survival Apoptotic TNF-family pathways
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

3 R&D Systems Pathways for TNFRSF1B

	TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF1B (see all 28)

	Caspase Cascade
	MAPK Signaling
	THC Differentiation Pathway
	TRAF Pathway
	Molecular Mechanisms of Cancer

2 Cell Signaling Technology (CST) Pathways for TNFRSF1B

	Apoptosis and Autophagy
	NF-kappaB Signaling

4 GeneGo (Thomson Reuters) Pathways for TNFRSF1B

	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
	Apoptosis and survival Apoptotic TNF-family pathways
	Transcription NF-kB signaling pathway
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

5/6 BioSystems Pathways for TNFRSF1B (see all 6)

	Apoptosis Modulation and Signaling
	Apoptosis
	IL-3 Signaling Pathway
	TNF-alpha/NF-kB Signaling Pathway
	TNF receptor signaling pathway

3 Kegg Pathways (Kegg details for TNFRSF1B):

	Cytokine-cytokine receptor interaction
	Adipocytokine signaling pathway
	Amyotrophic lateral sclerosis (ALS)

TNFRSF1B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TNFRSF1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/135 Interacting proteins for TNFRSF1B (P20333^{2, 3} ENSP00000365435⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 135)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALM2	P62158²^,³	MINT-49428 I2D: score=2
CALM3	P62158²^,³	MINT-49428 I2D: score=2
FANCD2	Q9BXW9²^,³	MINT-49427 MINT-48047 I2D: score=4
AIFM1	O95831²^,³, ENSP00000287295⁴	MINT-49368 I2D: score=2 STRING: ENSP00000287295
C1QBP	Q07021²^,³, ENSP00000225698⁴	MINT-49395 I2D: score=2 STRING: ENSP00000225698

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	IEA	--
GO:0007166	cell surface receptor signaling pathway	--	--
GO:0008219	cell death	--	--

TNFRSF1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TNFRSF1B for compounds About GeneDecksing

EMD Millipore small molecules for TNFRSF1B:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNFRSF1B
UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333

Pharmaceutical: Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid

arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc

chain. It binds to TNF-alpha and blocks its interactions with receptors

1 DrugBank Compound for TNFRSF1B About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Etanercept	CD120b (see all 7)	185243-69-0	target	--	11752352

10/80 Novoseek chemical compound relationships for TNFRSF1B gene (see all 80) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
etanercept	69.4	34	11574988 (1), 12110156 (1), 16796629 (1), 10904249 (1) (see all 29)
infliximab	54.4	13	19370184 (2), 12110156 (1), 19136378 (1), 12421092 (1) (see all 10)
tapi	52.1	4	7869036 (2)
neopterin	48.3	9	9764776 (2), 15642275 (2), 16273760 (1), 10973464 (1) (see all 6)
gp 130	41.1	7	10575186 (2), 19631179 (1), 19107325 (1), 10414448 (1) (see all 5)
il 10	29.6	9	12011375 (3), 8891726 (1), 11508666 (1), 19186969 (1)
fmlp	29.4	8	7998940 (3), 8946217 (1), 9886420 (1)
endotoxin	27.9	5	1322942 (1), 7622886 (1), 17244513 (1), 9185243 (1) (see all 5)
rantes	26.8	8	11562425 (2), 11504986 (2), 10843668 (1), 12376864 (1) (see all 6)
cuprophan	25.7	2	16988495 (1), 11509797 (1)

Search CenterWatch for drugs/clinical trials and news about TNFRSF1B / TNR1B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNFRSF1B gene:

NM_001066.2

Unigene Cluster for TNFRSF1B:

Tumor necrosis factor receptor superfamily, member 1B

Hs.256278 [show with all ESTs]

Unigene Representative Sequence: BC052977

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000376259(uc001att.3 uc009vnk.3) ENST00000492361(uc001atu.3)

ENST00000489921 ENST00000536782

miRNA Products:		OriGene 3'-UTR Clone: TNFRSF1B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFRSF1B
		8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFRSF1B (see all 37):
		hsa-miR-3938 hsa-let-7d hsa-miR-301a hsa-miR-486-3p hsa-let-7g hsa-let-7a hsa-miR-130b hsa-miR-301b

		SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF1B 3' UTR sequence

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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFRSF1B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF1B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF1B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TNFRSF1B (NM_001066)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF1B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF1B

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TNFRSF1B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF1B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF1B

Additional cDNA sequence:

AY148473.1 BC011844.2 BC042167.1 BC052977.1 BT019927.1 EU826615.1 M32315.1 M35857.1

M55994.1 S63368.1

7 DOTS entries:

DT.415651 DT.100823263 DT.100823260 DT.95169202 DT.100823259 DT.100823262 DT.101984571

24/183 AceView cDNA sequences (see all 183):

AA470868 F01858 BE138861 AI307670 AJ346375 AA972749 BU899219 CB069666

AI762184 BU158001 AA533208 AI247670 CA435681 BM993941 AI422018 T78122

CD610462 BC042167 BM129147 AW170706 S63368 AW468069 AI659001 NM_001066

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF1B About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b
SP1:											-
SP2:											-										-		-
SP3:									-		-
SP4:

ECgene alternative splicing isoforms for TNFRSF1B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNFRSF1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGAGCGCA

About this image

TNFRSF1B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 9 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Syncytiotrophoblast-like cells (Generation of syncyt...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TNFRSF1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFRSF1B

SOURCE GeneReport for Unigene cluster: Hs.256278

SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF1B (see all 12):

HIV Host Response in human mouse rat

NFKB Signaling Targets in human mouse rat

Multiple Sclerosis in human mouse rat

Lymphoma in human mouse rat

Apoptosis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFRSF1B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TNFRSF1B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF1B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF1B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF1B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF1B gene from 2/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TNFRSF1B¹	tumor necrosis factor receptor superfamily, member more	48.02(n) 38.37(a)		395083 NM_204439.2 NP_989770.2
zebrafish (Danio rerio)	Actinopterygii	zgc:163064¹	zgc:163064	41.4(n) 31.84(a)		100037357 NM_001089510.1 NP_001082979.1

ENSEMBL Gene Tree for TNFRSF1B (if available)
TreeFam Gene Tree for TNFRSF1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TNFRSF1B gene

TNFRSF21² TNFRSF6B² CD40² TNFRSF4² TNFRSF11A² TNFRSF9² NGFR² TNFRSF14²

TNFRSF11B² LTBR²

3 SIMAP similar genes for TNFRSF1B using alignment to 2 protein entries: TNR1B_HUMAN (see all proteins):

TNFR1B CD40 TNFRSF6B

TNFRSF1B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5745937^1,2	C,F,H,	--	11378594(+)	`CAGTCT/CGTTGG`	1	--	us2k¹		6		NS EA	510
rs652625^1,2	C,F,A,H,	--	11378600(-)	`ATGGGA/TCCAAC`	1	--	us2k¹		37		EA NA NS WA CSA	3630
rs5745938^1,2	C,F,	--	11378623(+)	`GTGTGG/TGGGAC`	1	--	us2k¹		5		NS NA	360
rs652599^1,2	C,F,	--	11378624(-)	`TGTCCC/TCCACA`	1	--	us2k¹		24		EA NA NS WA CSA	2748
rs5745940^1,2	C,F,	--	11379169(+)	`CTGGCA/CCTCAA`	1	--	us2k¹ tfbs³		6		NS NA WA	368
rs5745941^1,2	C,	--	11379183(+)	`GGGGAT/CGGGGG`	1	--	us2k¹		1		NS	156
rs5745942^1,2	C,F,	--	11379218(+)	`CTCGGT/CCATGA`	1	--	us2k¹		5		NS WA CSA	280
rs11807973^1,2	C,F,H,	--	11379222(+)	`GTCATG/TATGTA`	1	--	us2k¹ tfbs³		11		NS NA WA	870
rs56386304^1,2	C	--	11379472(+)	`GTAGAC/TACTTA`	1	--	us2k¹		1		WA	2
rs3753576^1,2	C,F,H,	--	11379519(-)	`AGATAT/CGTAAT`	1	--	us2k¹		4		EA NS NA	609
rs5745943^1,2	C,F,	--	11379637(+)	`AGCACC/ATTGGG`	1	--	us2k¹		5		NS NA	266
rs17881258^1,2	C,	--	11379875(+)	`CAAAAA/GAAATT`	1	--	us2k¹ tfbs³		2		NS	72
rs5745944^1,2	C,F,	--	11379921(+)	`TAAATA/GAGTGA`	1	--	us2k¹		4		NS WA CSA	185
rs76913963^1,2	F,	--	11379944(+)	`TCTCTT/CGGTTC`	1	--	us2k¹		1		WA	118
rs625847^1,2	C,F,	--	11379967(-)	`CAAAGC/TTGACA`	1	--	us2k¹		12		NS CSA NA	1958
rs5745945^1,2	C,	--	11379997(+)	`AGTGCC/TTCACC`	1	--	us2k¹		2		NS WA	246
rs36205948^1,2	C,	--	11380155(+)	`GGTATC/TGGCCC`	1	--	us2k¹		0	--	--	--	--
rs3079750^1,2	C,F	--	11380197(+)	`GCAGC-/AGCGTCTG`	1	--	us2k¹		1		NS	168
rs111566691^1,2	C,	--	11380216(+)	`CGTGGG/AGGAGG`	1	--	us2k¹		1		WA	2
rs17886039^1,2	C,F,	--	11380249(+)	`CGCCCC/TGCCCC`	1	--	us2k¹		2		NS	92
rs5745949^1,2	C,	--	11380324(+)	`GCGGAG/TCCTGG`	1	--	ut5¹		1		NS	164
rs5745951^1,2	F	--	11380370(+)	`AGGGC-/GCG AGGGCAGGGG`	1	--	ut5¹		1		NS	150
rs5745952^1,2	C,F	--	11380552(+)	`GTGCCC/GGGGCC`	1	--	int¹		2		NS WA	182
rs111314380^1,2	F	--	11381071(+)	`CGATGC/TGTCCG`	1	--	int¹		2		CSA	4
rs5745954^1,2	C,F,H,	--	11381091(+)	`GCAGAG/CTCTGT`	1	--	int¹		16		NS EA NA WA	1436
rs5745955^1,2	C,F,A,	--	11381115(+)	`TGGGGA/GCAGGG`	1	--	int¹		6		NS NA WA	354
rs5745956^1,2	C,F,A,	--	11381121(+)	`CAGGGC/GAAGCG`	1	--	int¹		8		NS EA NA WA	538
rs5745957^1,2	C,F,	--	11381483(+)	`GCTGCG/AGGGAA`	1	--	int¹		1		NS	180
rs72863459^1,2	C,	--	11381515(+)	`AGAGCC/TGCCCC`	1	--	int¹		1		WA	2
rs5745958^1,2	C,	--	11381564(+)	`TGACCG/AAGGAG`	1	--	int¹ trp³		1		NS	180
rs17880179^1,2	C,F,	--	11381841(+)	`CTGGCC/TTCAGA`	1	--	int¹		2		NS	92
rs11799476^1,2	H	--	11382019(+)	`TCCTGA/CGGCAG`	1	--	int¹		0	--	--	--	--
rs595254^1,2	C,F,A,	--	11382060(-)	`GGGGTC/GGTGGG`	1	--	int¹		12		EA NA MN NS WA CSA	434
rs112356758^1,2	F	--	11382120(+)	`TCTCCC/AGCTGA`	1	--	int¹		2		CSA	4
rs17884595^1,2	C,F,	--	11382260(+)	`TTCCTC/TGCGCC`	1	--	int¹		5		NS NA	218
rs480602^1,2	C,F,	--	11382689(-)	`agttgC/Ttgtaa`	1	--	int¹		4		NA NS	98
rs113058379^1,2	F,	--	11383287(+)	`CTGGAC/TGTCAA`	1	--	int¹		2		CSA	4
rs17883094^1,2	C,F,	--	11383331(+)	`CCTGGG/AGGCTC`	1	--	int¹		6		NS NA CSA WA	336
rs61582400^1,2	C,	--	11383555(+)	`GCTCTG/CGGGAC`	1	--	int¹		1		WA	2
rs17878920^1,2	C,	--	11383644(+)	`CCAACT/AGCCCT`	1	--	int¹		2		NS	94
rs17878610^1,2	C,F,	--	11383695(+)	`TGGTTG/TTGGAA`	1	--	int¹		11		NS WA	1818
rs674846^1,2	C,F,	--	11383772(-)	`TCTGAC/TGTAAG`	1	--	int¹		7		EA NA NS	152
rs1476242^1,2		--	11383799(-)	`GCCAGA/GTGCCA`	1	--	int¹		0	--	--	--	--
rs559011^1,2	C,F,A,H,	--	11383881(-)	`CTCCTC/GCAGAA`	1	--	int¹		17		NS EA NA WA CSA	2134
rs4570435^1,2	H	--	11384831(+)	`tttgtA/Tttcct`	1	--	int¹		4		NS EA	396
rs12062134^1,2	C,F,H,	--	11384904(+)	`agtacC/Tgtgag`	1	--	int¹		12		NS EA NA WA	1308
rs17884395^1,2	C,	--	11385391(+)	`AGTGAG/AGGATG`	1	--	int¹		4		NS NA	98
rs17882445^1,2	C	--	11385594(+)	`TCTGAA/GTCAGA`	1	--	int¹		2		NS	88
rs11809661^1,2	C,F,H,	--	11385766(+)	`GCTATT/ATGAGC`	1	--	int¹		20		NS EA NA CSA WA	1958
rs79823881^1,2	F,	--	11385904(+)	`CCTGCA/GGTTGC`	1	--	int¹		1		EA	120
rs113827931^1,2	F	--	11385953(+)	`TCAGAG/AAGCAA`	1	--	int¹		2		CSA	4
rs5745959^1,2	H	--	11386210(+)	`AGATGG/AGCACG`	1	--	int¹		5		NS EA	576
rs5745960^1,2	H	--	11386248(+)	`TCTTCC/TATCTC`	1	--	int¹		5		NS EA	600
rs111787782^1,2		--	11386255(+)	`TCTCCG/AACCTC`	1	--	int¹		1		CSA	2
rs494964^1,2	C,F,H,	--	11386258(-)	`ACAGAG/AGTTGG`	1	--	int¹		21		NS EA NA WA	2312
rs112865510^1,2		--	11386512(+)	`CCTAAC/TAACCC`	1	--	int¹		1		CSA	2
rs5745961^1,2	C,F,H,	--	11386554(+)	`AGTGTC/TGGCTT`	1	--	int¹		10		NS EA NA	802
rs17881100^1,2	C	--	11387049(+)	`TGCCCC/TCTTCC`	1	--	int¹		2		NS	90
rs976880^1,2		--	11387324(-)	`CTCCCC/TCCGCA`	1	--	int¹ trp³		1		NA	2
rs816052^1,2		--	11387569(-)	`agaagG/Aagaag`	1	--	int¹ trp³		2		NA	4
rs28370455^1,2		--	11387575(+)	`CTTCTT/CCTTCT`	1	--	int¹ trp³		2		NA	4
rs5745964^1,2	C,F,	--	11387774(+)	`CAGGCT/AGGTCT`	1	--	int¹		6		NS NA	264
rs5745965^1,2	C,F,	--	11387781(+)	`GTCTCG/CAACTC`	1	--	int¹		5		NS NA	258
rs598492^1,2	C,F,	--	11387878(-)	`CTACTT/CTNNNN`	1	--	int¹		13		NA NS WA EA	1100
rs597991^1,2	C,F,	--	11388023(-)	`CTGGGG/TCCTGA`	1	--	int¹		6		EA NA NS	148
rs5745966^1,2	C,	--	11388033(+)	`GGAGGG/ACCAGC`	1	--	int¹		1		NS	176
rs17883924^1,2	C,	--	11388051(+)	`CCTACC/TCCCTC`	1	--	int¹ trp³		3		NS NA	92
rs597519^1,2	C,F,A,H,	--	11388141(-)	`AGTACA/GTCTGA`	1	--	int¹		23		EA NA NS WA	2602
rs12090385^1,2	C,F,H,	--	11388239(+)	`ACAGCG/ACAGAA`	1	--	int¹		15		NS EA NA WA	1268
rs17881374^1,2	C,	--	11388388(+)	`AGAGCG/AGGAGG`	1	--	int¹		2		NS	90
rs5745967^1,2	C,F,	--	11388427(+)	`GGGAGG/AGGGGA`	1	--	int¹ trp³		5		NS NA	392
rs5745968^1,2	C,H,	--	11388575(+)	`GGAGAA/GCTTGG`	1	--	int¹		5		NS EA	590
rs5745969^1,2	C,F,	--	11388687(+)	`GGTGGA/GGTGCA`	1	--	int¹		5		NS NA	272
rs113533746^1,2	C,	--	11388704(+)	`ACTGCC/TACGTC`	1	--	int¹		2		WA	120
rs5745971^1,2	C,F,	--	11388712(+)	`GTCACC/TCAGCT`	1	--	int¹		7		NS NA EA	514
rs17881148^1,2	C,	--	11388980(+)	`CCCAGC/GTCCCT`	1	--	int¹		4		NS NA	94
rs78080119^1,2	F,	--	11388988(+)	`CCTCAA/GGCCCC`	1	--	int¹		1		EA	120
rs112014585^1,2	C,	--	11389416(+)	`AGTCCC/TAGCTA`	1	--	int¹		1		WA	2
rs61196697^1,2		--	11389486(+)	`GAGATC/TGCACC`	1	--	int¹		0	--	--	--	--
rs111721409^1,2	C,	--	11389583(+)	`TGTTAG/-GACTG`	1	--	int¹		1		CSA	2
rs12568440^1,2	H	--	11390290(+)	`CCTGAA/GCCCTG`	1	--	int¹		0	--	--	--	--
rs17880241^1,2	C,F	--	11390307(+)	`AGCCCTGAG CCC/-AATGG`	1	--	int¹		2		NS	88
rs17885672^1,2	C,F,	--	11390461(+)	`CAGGCG/ATGCCC`	1	--	int¹		2		NS	86
rs17882727^1,2	C,	--	11390626(+)	`CAGTGG/AACTGA`	1	--	int¹		3		NS WA	206
rs72863473^1,2	C,	--	11390677(+)	`CAGTCG/AGTCAC`	1	--	int¹		2		WA	120
rs17884298^1,2	C,F,	--	11390833(+)	`CGCTGC/TTACCC`	1	--	int¹		4		NS CSA WA	210
rs111730934^1,2	C,	--	11391030(+)	`TGAACC/TTGGGA`	1	--	int¹		1		WA	2
rs17885967^1,2	C,F,	--	11391234(+)	`AACATC/TATCCC`	1	--	int¹		9		NS NA WA CSA	336
rs17884096^1,2	C,	--	11391239(+)	`CATCCC/ACATTT`	1	--	int¹		3		NS WA	206
rs113060175^1,2	F	--	11391403(+)	`GAGCCG/ACTGTC`	1	--	int¹		2		CSA	4
rs112156978^1,2	C,	--	11391452(+)	`CGCCGC/TCCCCT`	1	--	int¹		2		WA	120
rs72642617^1,2		--	11391872(+)	`CGGGTA/GTGGGC`	1	--	int¹		0	--	--	--	--
rs17879922^1,2	C	--	11391994(+)	`GGTCGG/AGGGTG`	1	--	int¹		2		NS	90
rs17879634^1,2	C,F,	--	11392002(+)	`GTGGCG/AGGTCA`	1	--	int¹		3		NS CSA	91
rs5745972^1,2	C,F,	--	11392085(+)	`TGTGAC/GAGCAA`	1	--	int¹		4		NS WA CSA	172
rs645984^1,2	C,F,A,	--	11392143(-)	`CCTGCG/ACAACC`	1	--	int¹		9		NS EA NA WA CSA	444
rs5745973^1,2	C,F,H,	--	11392226(+)	`AGGGAC/TAGAAG`	1	--	int¹		16		NS EA NA WA	1444
rs17885508^1,2	C,F,	--	11392283(+)	`GGGCAG/TCGAGG`	1	--	int¹		3		NS WA	212
rs112768017^1,2		--	11392285(+)	`GCAGCG/AAGGAG`	1	--	int¹		1		CSA	2
rs5745974^1,2	H	--	11392299(+)	`GGGTCG/ATGGGA`	1	--	int¹		5		NS EA	580
rs499646^1,2	C,F,A,H,	--	11392345(-)	`CCCACC/TGTCAC`	1	--	int¹		13		NS EA NA WA CSA	936
rs5745975^1,2	C,F,	--	11392407(+)	`ATGCCC/TGGCGT`	1	--	int¹		5		NS NA	394
rs632756^1,2	C,F,A,H,	--	11392776(-)	`ACCACG/ATCATT`	1	--	int¹		16		NS EA NA	1534
rs5745977^1,2	C,F,H,	--	11392786(+)	`TTTCCG/ACATTG`	1	--	int¹		18		NS EA NA CSA WA	1992
rs632656^1,2	C,F,	--	11392839(-)	`AGGTAT/CCTGCC`	1	--	int¹		5		NA NS	274
rs111320489^1,2		--	11392860(+)	`CCACAG/CCTTTG`	1	--	int¹		1		CSA	2
rs112865440^1,2	F,	--	11392944(+)	`GTTCAC/TAGAAG`	1	--	int¹		2		CSA	4
rs5745978^1,2	C,	--	11393254(+)	`AGTCTC/TTGTTC`	1	--	int¹		1		NS	176
rs5745979^1,2	F	--	11393305(+)	`CTGAAG/ACTTCT`	1	--	int¹		1		NS	176
rs5745980^1,2	C,F,H,	--	11393353(+)	`TCAGCG/AGGTAG`	1	--	int¹		6		NS EA WA	596
rs5745981^1,2	C,F,H,	--	11393402(+)	`GCATGA/TCCTCT`	1	--	int¹		11		NS EA NA	1730
rs77209231^1,2	F,	--	11393465(+)	`AGGCCG/AGGCAC`	1	--	int¹		1		EA	120
rs5745982^1,2	H	--	11393596(+)	`AAAATA/TATAAT`	1	--	int¹		5		NS EA	582
rs5745985^1,2	C,F,H,	--	11393852(+)	`GACGCA/TAACTC`	1	--	int¹		8		NS EA NA WA	598
rs17880448^1,2	C,F,	--	11393948(+)	`ACCTGC/TAGCCC`	1	--	int¹		3		NS CSA	82
rs5745987^1,2	C,F,	--	11393978(+)	`CTGAGT/GCCTCC`	1	--	int¹		7		NS NA CSA WA	378
rs3766728^1,2	C,H,	--	11394146(-)	`GACGAT/CGCGGC`	1	--	int¹		6		EA NS	1990
rs3766727^1,2	H	--	11394201(-)	`TCTGGG/ATGAGT`	1	--	int¹		4		NS EA	406
rs550132^1,2	C,F,A,H,	--	11394306(-)	`AGTGCA/GACAGG`	1	--	int¹		23		NS EA NA WA CSA	2702
rs527189^1,2	C,F,	--	11394518(-)	`GTGTTA/GGATGG`	1	--	int¹		3		NS WA CSA	162
rs525283^1,2	C,F,A,	--	11394725(-)	`GCCCCT/CGGGGA`	1	--	int¹		9		NS NA WA CSA	487
rs17884036^1,2	C,	--	11394848(+)	`GACCCA/GCTACC`	1	--	int¹		3		NS WA	212
rs5745988^1,2	H	--	11394867(+)	`CTGGCG/AGTGCA`	1	--	int¹		5		NS EA	556
rs5745989^1,2	C,F,H,	--	11394928(+)	`TCAGCG/ACCCCT`	1	--	int¹		9		NS EA NA	790
rs17880756^1,2	C,F,	--	11395109(+)	`GCCCAA/GCTCTG`	1	--	int¹		5		NS NA	206
rs5745991^1,2	C,F,	--	11395111(+)	`CCAACT/GCTGCC`	1	--	int¹		16		NS NA WA CSA	1087
rs5745992^1,2	C,F	--	11395242(+)	`AAGAAC/TCCAGG`	1	--	int¹		5		NS NA	254
rs72863484^1,2	C,	--	11395335(+)	`ACTGCC/TCACAG`	1	--	int¹		1		WA	2
rs519064^1,2	C,F,H,	--	11395352(-)	`CTCAAG/ATGTCT`	1	--	int¹		17		NS EA NA CSA	1446
rs17880104^1,2	C,F,	--	11395765(+)	`TTGAAC/TGTGCA`	1	--	int¹		8		NS	732
rs17885226^1,2	F	--	11395896(+)	`TGAAT-/GAAT CACTG`	1	--	int¹		2		NS	80
rs17881409^1,2	C,	--	11396015(+)	`TTTTAT/AACAGT`	1	--	int¹		4		NS NA	200
rs17878859^1,2	C,F,	--	11396397(+)	`TAACAC/TGCACA`	1	--	int¹		4		NS CSA	92
rs12043781^1,2	H	--	11396673(+)	`ATCTCA/CTCTGT`	1	--	int¹		4		NS EA	398
rs680537^1,2		--	11397010(-)	`gatagA/Ctagat`	1	--	int¹		0	--	--	--	--
rs1201133^1,2	A,	--	11397063(-)	`gctagC/Atagat`	1	--	int¹		2		NA	4
rs113299493^1,2		--	11397075(+)	`AGCTAT/GCTAGC`	1	--	int¹		1		CSA	1
rs76769120^1,2	C,	--	11397079(+)	`AGCTAG/TCTATC`	1	--	int¹		1		WA	2
rs17885609^1,2	C,F,	--	11397422(+)	`CCCCAA/GTCCAA`	1	--	int¹		9		NS WA	838
rs17880321^1,2	C,F,	--	11397492(+)	`TGGGGA/-CCTCC`	1	--	int¹		2		NS	86
rs72863491^1,2	C,	--	11397754(+)	`CACAGG/AGCCAG`	1	--	int¹		1		WA	2
rs78400727^1,2		--	11397958(+)	`GCCCTC/TGTCCA`	1	--	int¹		0	--	--	--	--
rs17885692^1,2	C,F,	--	11397968(+)	`ATTGCG/AGCTCT`	1	--	int¹		4		NS NA	98
rs12048984^1,2	H	--	11398406(+)	`CTGCCG/ACAGTT`	1	--	int¹		4		NS EA	390
rs4845897^1,2	C,F,A,	--	11398986(+)	`GGGCCT/ACCGGG`	1	--	int¹		7		NS NA WA EA	450
rs17885470^1,2	C	--	11399032(+)	`TTTGCG/AGCCCT`	1	--	int¹		2		NS	88
rs72642622^1,2		--	11399063(+)	`ACAGGA/GAAGGA`	1	--	int¹		0	--	--	--	--
rs17883216^1,2	C,	--	11399435(+)	`AGGAAG/TCCCCA`	1	--	int¹		2		NS	70
rs74053354^1,2	C,	--	11399437(+)	`GAAGCC/ACCAGC`	1	--	int¹		2		WA	120
rs1201131^1,2		--	11399716(-)	`GCACCG/ACTGGG`	1	--	int¹		3		MN NA	188
rs5745994^1,2	C,F,H,	--	11400382(+)	`GAGACC/TCGAGA`	1	--	int¹		9		NS EA NA	734
rs5745995^1,2	C,H,	--	11400516(+)	`TGGAAG/ATGCAG`	1	--	int¹		5		NS EA	594
rs55744188^1,2	C,	--	11400521(+)	`GTGCAG/ATGGCA`	1	--	int¹		1		WA	2
rs5745997^1,2	C,F,	--	11400620(+)	`CCACTA/GTGCCG`	1	--	int¹		2		NS WA	176
rs606380^1,2		--	11400749(-)	`tggtgA/Gctcac`	1	--	int¹		0	--	--	--	--
rs17881487^1,2	C,	--	11400764(+)	`TGGCCC/TTCTCT`	1	--	int¹ trp³		3		NS WA	186
rs529932^1,2	H,	--	11400781(-)	`GTGATG/AAATGA`	1	--	int¹		4		NS EA	410
rs2301258^1,2	C,F,	--	11401194(+)	`TTGTAC/TCAGGG`	1	--	int¹		8		NS NA WA	1308
rs5745999^1,2	C,F,H,	--	11401197(+)	`TACCAG/TGGTGG`	1	--	int¹		6		NS EA WA	568
rs603686^1,2	H,	--	11401361(-)	`tgaagC/Aactgc`	1	--	int¹		6		NS EA NA	418
rs5746000^1,2	C,F,H,	--	11401604(+)	`CCCACG/ATTTAG`	1	--	int¹		5		NS EA	582
rs59033706^1,2	C,	--	11401751(+)	`TCCTCA/GGCAGA`	1	--	int¹		2		WA	120
rs17884281^1,2	C,F,	--	11401781(+)	`ACCCCC/TGTTCT`	1	--	int¹		3		NS CSA	92
rs5746002^1,2	C,F,H,	--	11401812(+)	`TTCTGG/AATATC`	1	--	int¹		10		NS EA NA WA	790
rs17883721^1,2	C,	--	11401847(+)	`CCCAGC/TACTGG`	1	--	int¹		3		NS WA	206
rs590943^1,2	C,F,H,	--	11401939(-)	`GAGCTC/TGTGCC`	1	--	int¹		16		EA NA NS CSA WA	932
rs5746003^1,2	C,F,H,	--	11401993(+)	`TCATCA/TGTGCA`	1	--	int¹		15		NS EA NA WA	1458
rs5746004^1,2	C,F,H,	--	11402338(+)	`CCCTGC/GTGCTT`	1	--	int¹		6		NS EA CSA	598
rs5746005^1,2	C,F,H,	--	11402380(+)	`TGGCAC/TACTTC`	1	--	int¹		5		NS EA	598
rs74053356^1,2	C,F,	--	11402468(+)	`CCTGCC/ACCATA`	1	--	int¹		2		WA CSA	4
rs5746007^1,2	C,F,	--	11402559(+)	`GCACTC/TAGCTT`	1	--	int¹		6		NS NA	332
rs5746008^1,2	C,H,	--	11402628(+)	`TCTTTC/TCTTGC`	1	--	int¹ trp³		5		NS EA	584
rs5746009^1,2	C,F,H,	--	11402822(+)	`NNNNCA/CGTTGG`	1	--	int¹		16		NS EA WA CSA NA	1494
rs56143124^1,2	C,F,	--	11403070(+)	`TAAGGC/TGGGGG`	1	--	int¹		2		WA CSA	4
rs113904142^1,2		--	11403137(+)	`AGGTGG/ACATTT`	1	--	int¹		1		CSA	2
rs5746011^1,2	C,F,H,	--	11403258(+)	`GTGAGT/CTGGAG`	1	--	int¹		6		NS EA NA	704
rs17883858^1,2	C,	--	11403336(+)	`GGAGTG/AAGCAG`	1	--	int¹		5		NS NA	210
rs681906^1,2	C,F,H,	--	11403348(-)	`TTACCA/Gtggtc`	1	--	int¹		10		NS EA NA CSA	660
rs5746012^1,2	C,F,H,	--	11403442(+)	`GTCACC/AGTCCC`	1	--	int¹		9		NS EA NA	684
rs5746013^1,2	H	--	11403923(+)	`CCCCTA/GTCATT`	1	--	int¹		5		NS EA	568
rs5746014^1,2	C,F,H,	--	11404142(+)	`GGAATT/CGGAAC`	1	--	int¹		26		NS EA NA	2750
rs5746015^1,2	C,F,	--	11404148(+)	`GGAACT/GCCACA`	1	--	int¹		7		NS NA WA	376
rs17880212^1,2	C	--	11404212(+)	`TGAGCC/TCAGGG`	1	--	int¹		2		NS	92
rs11121885^1,2	C,F,	--	11404532(+)	`CTGTTT/CACCCC`	1	--	int¹		3		NA NS	92
rs5746017^1,2	C,F,	--	11404595(+)	`GGGGCA/CGGCGG`	1	--	int¹		7		NS NA WA CSA	248
rs17880213^1,2	C	--	11404739(+)	`GACTTC/TGGGGA`	1	--	int¹		3		NS NA	94
rs5746019^1,2	C,F,	--	11404754(+)	`CGGCAC/TTGCGG`	1	--	int¹		2		NS NA	276
rs111378612^1,2		--	11404776(+)	`ACTGCG/AGGGAG`	1	--	int¹		1		CSA	1
rs5746023^1,2	H	--	11405297(+)	`CCTTGC/TAGTGT`	1	--	int¹		5		NS EA	582
rs5746024^1,2	H	--	11405315(+)	`ATCAAC/TCCATT`	1	--	int¹		5		NS EA	584
rs13306721^1,2	H	--	11405470(+)	`TCAGAC/ACAAGC`	1	--	int¹		4		NS EA	420
rs17881199^1,2	C,	--	11405556(+)	`ACAGGA/CATCTG`	1	--	int¹		2		NS	86
rs5746029^1,2	H	--	11406552(+)	`TGAGAC/TTGCTT`	1	--	int¹		5		NS EA	594
rs17883608^1,2	C,F,	--	11407046(+)	`CTGGGG/ATAGAA`	1	--	int¹		4		NS NA	80
rs17882921^1,2	C,F,	--	11407153(+)	`AGACTC/TGCCCC`	1	--	int¹		3		NS WA	78
rs17879042^1,2	C	--	11407283(+)	`GTGTGA/CCAGCC`	2	T P	mis¹ ese³		4		NS NA	78
rs111772337^1,2	F	--	11407485(+)	`AAGGCG/CTGGGG`	1	--	int¹		2		CSA	4
rs56286668^1,2	C,	--	11407704(+)	`TGGGGG/TACTGG`	1	--	int¹		1		WA	2
rs5746034^1,2	H	--	11408037(+)	`TGTCAG/TGAGGT`	1	--	int¹		5		NS EA	532
rs5746036^1,2	C,F,H,	--	11408442(+)	`GTAGAG/TGCTGT`	1	--	int¹		5		NS EA	576
rs5746037^1,2	H	--	11408530(+)	`TTAGAG/CACAGA`	1	--	int¹		5		NS EA	584
rs76468815^1,2	F,	--	11408812(+)	`GTCACC/GTCTAA`	1	--	int¹		1		WA	118
rs5746038^1,2	C,H,	--	11408879(+)	`AAATCG/AGATGC`	1	--	int¹		5		NS EA	566
rs5746039^1,2	H	--	11408882(+)	`TCGGAT/CGCCTT`	1	--	int¹		5		NS EA	564
rs5746041^1,2	C,F,H,	--	11409058(+)	`ACATAC/GGTCTG`	1	--	int¹		6		NS EA WA	682
rs72864906^1,2	C,	--	11409318(+)	`TTTTTT/AAAAAG`	1	--	int¹		1		WA	2
rs235253^1,2	C,F,H,	--	11409425(+)	`tggccA/Gtcatg`	1	--	int¹		9		NS EA NA CSA	514
rs17881105^1,2	C,F,	--	11410044(+)	`CCGGCG/AAGCGA`	1	--	int¹		2		NS	92
rs235252^1,2		--	11410093(+)	`ACTGAC/TGGTTG`	1	--	int¹		6		EA NA CSA	60
rs75362147^1,2	F,	--	11410124(+)	`AGCAGG/TTGTCT`	1	--	int¹		1		WA	118
rs17883122^1,2	C,F,	--	11410195(+)	`CAATCC/GTCTGT`	1	--	int¹		5		NS NA	212
rs113856503^1,2	C,	--	11410251(+)	`TTCCAT/-TTTTT`	1	--	int¹		1		CSA	2
rs235251^1,2	C,F,A,H,	--	11410644(+)	`AGTGCA/GGAAAA`	1	--	int¹		11		NS EA NA CSA WA	854
rs170958^1,2	F,H,	--	11410910(+)	`ccattT/Cttcct`	1	--	int¹		8		NS EA NA CSA WA	510
rs77315368^1,2	F,	--	11411019(+)	`GAGGCC/TAGTGG`	1	--	int¹		1		EA	120
rs112443907^1,2		--	11411023(+)	`CCAGTG/AGAGAG`	1	--	int¹		1		CSA	2
rs74548359^1,2	F,	--	11411107(+)	`GTCCAG/CGGCAT`	1	--	int¹		1		WA	118
rs17881895^1,2	C,	--	11411296(+)	`CCGGGC/TGTGGT`	1	--	int¹		2		NS	74
rs17885868^1,2	C,F,	--	11411309(+)	`CGGGCG/ACCCGT`	1	--	int¹		2		NS	76
rs17881602^1,2	C,F,	--	11411357(+)	`GAACCC/TGGGAG`	1	--	int¹		2		NS	76
rs235250^1,2	C,F,A,	--	11411428(+)	`actccA/Gtctca`	1	--	int¹		6		NA NS CSA	79
rs17883976^1,2	C,F,	--	11411541(+)	`TTTATC/TGGGTG`	1	--	int¹		4		NS NA	88
rs71647033^1,2	C	--	11411910(+)	`TGGCTT/CTGCTG`	1	--	int¹		2		NA	4
rs1889793^1,2		--	11412458(-)	`AGGTCA/GCGGCC`	1	--	int¹		1		MN	184
rs235248^1,2	C,F,	--	11412637(+)	`CCACCT/CGGGCG`	1	--	int¹		13		NS NA WA CSA	880
rs80340895^1,2		--	11413438(+)	`CGTGAC/GCTTGG`	1	--	int¹		1		NA	120
rs75369812^1,2	F,	--	11413488(+)	`GCAAGG/CATAAC`	1	--	int¹		1		NA	120
rs17881379^1,2	C,F,	--	11413601(+)	`ATTCTA/GCGGGA`	1	--	int¹		8		NS	742
rs17880252^1,2	C,F,	--	11413644(+)	`GTGGGC/TGGACT`	1	--	int¹		3		NS CSA	96
rs17880518^1,2	C,F,	--	11413663(+)	`AGAGGC/TTGAGG`	1	--	int¹		5		NS NA	218
rs113521532^1,2		--	11413741(+)	`TGCACG/ACTTTC`	1	--	int¹		1		CSA	2
rs5746046^1,2	H	--	11413944(+)	`CCGCAA/GATTAT`	1	--	int¹		5		NS EA	558
rs5746048^1,2	C,F,	--	11414131(+)	`GAGACG/AGGGTT`	1	--	int¹		1		NS	162
rs12134694^1,2	C	--	11414463(+)	`gtggtC/Ttcagc`	1	--	int¹		1		NA	2
rs17881207^1,2	C,F,	--	11414877(+)	`GCACTT/CGTGTG`	1	--	int¹		4		NS NA	74
rs17885670^1,2	C,F,	--	11415054(+)	`CCTCAT/CAGGAC`	1	--	int¹		4		NS NA WA	210
rs5746050^1,2	H	--	11415106(+)	`AACCAC/TGGAGA`	1	--	int¹		5		NS EA	588
rs17883432^1,2	C	--	11415289(+)	`CCAGCC/GTCACT`	2	P R	mis¹ ese³		4		NS NA	96
rs111941714^1,2		--	11415823(+)	`CCTTTG/CACAGG`	1	--	int¹		1		CSA	2
rs113380808^1,2		--	11415874(+)	`CCCACG/ACCAGG`	1	--	int¹		1		CSA	2
rs5746055^1,2	C,F,	--	11415940(+)	`CAACAC/TGGCCC`	1	--	int¹		6		NS NA CSA	272
rs235224^1,2	C,F,	--	11416179(+)	`gctgtC/Tgggct`	1	--	int¹		6		NA NS WA CSA	100
rs17884378^1,2	C,F,	--	11416781(+)	`GCCACC/ACCTGC`	1	--	int¹		4		NS NA	216
rs17884213^1,2	C,F,	--	11416809(+)	`ACCTGC/TCCCCA`	1	--	int¹		17		NS NA CSA WA EA	2067
rs17883933^1,2	C,F,	--	11416850(+)	`TGTCTG/ACCCCA`	1	--	int¹		3		NS CSA	96
rs235223^1,2	H	--	11416998(+)	`AGTGCG/ACTCCA`	1	--	int¹		6		NS EA NA	414
rs235222^1,2	C	--	11417059(+)	`tttttA/Taatgg`	1	--	int¹		2		NA WA	4
rs235220^1,2	C,F,A,	--	11417183(+)	`gtaggC/Tgggat`	1	--	int¹		12		EA NA NS WA CSA	465
rs17886043^1,2	C,F,	--	11417487(+)	`CCGTGT/CCCCTG`	1	--	int¹		5		NS NA	174
rs17884550^1,2	C,F,	--	11417586(+)	`GTCCCC/GCATCC`	1	--	int¹		4		NS NA	182
rs17886580^1,2	C,F,	--	11417725(+)	`TGCTTG/AGGGCT`	1	--	int¹		4		NS NA	202
rs235218^1,2	C,A,	--	11418135(+)	`caccaC/AcaACA`	1	--	int¹		2		NA	4
rs75701676^1,2	F,	--	11418340(+)	`AAAAAA/GATAAA`	1	--	int¹		1		NA	120
rs74389328^1,2	F,	--	11418643(+)	`TGTGGC/TTGGAA`	1	--	int¹		1		EA	120
rs17883882^1,2	C,	--	11418839(+)	`AGCCAG/AGACAG`	1	--	int¹		3		NS NA	94
rs2077000^1,2	C,F,	--	11419717(-)	`TAGTGA/GGACCC`	1	--	int¹		6		NS NA WA	340
rs5746061^1,2	C,F,H,	--	11419855(+)	`ATGCTA/GTTCTT`	1	--	int¹		19		NS EA NA WA CSA	1571
rs5746063^1,2	C,F,	--	11419920(+)	`ACACAG/TCAGAG`	1	--	int¹		2		NS NA	260
rs13306715^1,2	C,F,	--	11419946(+)	`ggtctC/Tggctc`	1	--	int¹		1		WA	118
rs200873417^1,2	C	--	11420479(+)	`TGCCCC/TCCACA`	1	--	ut3¹		0	--	--	--	--
rs5030792^1,2	C,	--	11420534(+)	`AGTTGT/GGGAAA`	1	--	ut3¹		2		NA	122
rs5746066^1,2	C,F,	--	11420794(+)	`GAGGGA/GTGCTG`	1	--	ut3¹ ese³ trp³		3		NS	242
rs5746067^1,2	C	--	11420813(+)	`ACCCAT/CGAAGA`	1	--	ut3¹ ese³		3		NS NA	152
rs5746068^1,2	C,F,H,	--	11420819(+)	`GAAGAC/GAGGAC`	1	--	ut3¹ ese³		19		NS EA NA WA	1906
rs17880792^1,2	C,F	--	11420862(+)	`GGTCCT/CGGGGC`	1	--	ut3¹		3		NS NA	96
rs17881445^1,2	C,F,H	--	11420915(+)	`CTTCAA/GGTTAG`	1	--	ut3¹ ese³		5		NS NA	382
rs17880332^1,2	C,	--	11420970(+)	`TCACGC/TCTATG`	1	--	ut3¹ ese³		2		NS	94
rs5746069^1,2	C,	--	11421001(+)	`TGAGGC/TGGGTG`	1	--	ut3¹ ese³		1		NS	166
rs5746071^1,2	C,F	--	11421292(+)	`GTGAA-/TGAA AGTCA`	1	--	ut3¹		1		NS	152
rs6668561^1,2	H	--	11421422(+)	`GCCAAC/TGACAA`	1	--	ut3¹ ese³		4		NS EA	416
rs61774891^1,2		--	11421474(+)	`TTGCAT/CCCTCC`	1	--	ut3¹		1		NA	2
rs113401157^1,2		--	11421490(+)	`CACTCC/TGGTGT`	1	--	ut3¹		1		CSA	2
rs5746072^1,2	C,H,	--	11421519(+)	`CCTTCC/TTTGCT`	1	--	ut3

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TNFRSF1B Gene

tumor necrosis factor receptor superfamily, member 1B

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for TNFRSF1B gene

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for TNFRSF1B gene

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for TNFRSF1B gene

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for TNFRSF1B gene

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for TNFRSF1B gene

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TNFRSF1B Gene

tumor necrosis factor receptor superfamily, member 1B

Aliasesfor TNFRSF1B gene

Summariesfor TNFRSF1B gene

Genomic Viewsfor TNFRSF1B gene

Proteinsfor TNFRSF1B gene

Protein Domains /Familiesfor TNFRSF1B gene

Functionfor TNFRSF1B gene

Pathways & Interactionsfor TNFRSF1B gene

Drugs & Compoundsfor TNFRSF1B gene

Transcriptsfor TNFRSF1B gene

Expression for TNFRSF1B gene

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for TNFRSF1B gene

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for TNFRSF1B gene

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for TNFRSF1B gene

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for TNFRSF1B gene

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for TNFRSF1B gene

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for TNFRSF1B gene

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for TNFRSF1B gene

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for TNFRSF1B gene

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for TNFRSF1B gene

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for TNFRSF1B gene

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for TNFRSF1B gene

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for TNFRSF1B gene

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for TNFRSF1B gene