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Aliases for TNFRSF1B Gene

Aliases for TNFRSF1B Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 1B 2 3
  • TNFR2 3 4 6
  • TNFBR 3 4 6
  • Tumor Necrosis Factor Receptor Type II 3 4
  • Tumor Necrosis Factor Receptor 2 3 4
  • P80 TNF-Alpha Receptor 3 4
  • TNF-RII 3 4
  • TNF-R2 3 4
  • P75 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 1B 3
  • Tumor Necrosis Factor Binding Protein 2 3
  • Tumor Necrosis Factor Beta Receptor 3
  • Soluble TNFR1B Variant 1 3
  • P75 TNF Receptor 3
  • CD120b Antigen 4
  • Etanercept 4
  • TNF-R-II 3
  • TNF-R75 3
  • P75TNFR 3
  • TNFR-II 4
  • CD120b 3
  • TNFR1B 3
  • TNFR80 3
  • TBPII 3

External Ids for TNFRSF1B Gene

Previous Symbols for TNFRSF1B Gene

  • TNFR2

Summaries for TNFRSF1B Gene

Entrez Gene Summary for TNFRSF1B Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF1B Gene

TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B) is a Protein Coding gene. Diseases associated with TNFRSF1B include post-transplant lymphoproliferative disease and pneumococcal meningitis. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include ubiquitin protein ligase binding and tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF14.

UniProtKB/Swiss-Prot for TNFRSF1B Gene

  • Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Gene Wiki entry for TNFRSF1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF1B Gene

Genomics for TNFRSF1B Gene

Genomic Location for TNFRSF1B Gene

12,167,003 bp from pter
12,209,228 bp from pter
42,226 bases
Plus strand

Genomic View for TNFRSF1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF1B Gene

Regulatory Elements for TNFRSF1B Gene

Transcription factor binding sites by QIAGEN in the TNFRSF1B gene promoter:

Proteins for TNFRSF1B Gene

  • Protein details for TNFRSF1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 1B
    Protein Accession:
    Secondary Accessions:
    • B1AJZ3
    • Q16042
    • Q6YI29
    • Q9UIH1

    Protein attributes for TNFRSF1B Gene

    461 amino acids
    Molecular mass:
    48291 Da
    Quaternary structure:
    • Binds to TRAF2. Interacts with BMX.

    Three dimensional structures from OCA and Proteopedia for TNFRSF1B Gene

    Alternative splice isoforms for TNFRSF1B Gene


neXtProt entry for TNFRSF1B Gene

Proteomics data for TNFRSF1B Gene at MOPED

Post-translational modifications for TNFRSF1B Gene

  • A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing
  • Phosphorylated; mainly on serine residues and with a very low level on threonine residues
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn171, Asn193, Ser208, Ser221, and Thr222

Other Protein References for TNFRSF1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFRSF1B Gene

Domains for TNFRSF1B Gene

Gene Families for TNFRSF1B Gene

  • CD :CD molecules
  • TNFRSF :Tumor necrosis factor receptor superfamily

Protein Domains for TNFRSF1B Gene


  • Contains 4 TNFR-Cys repeats.:
    • P20333
genes like me logo Genes that share domains with TNFRSF1B: view

Function for TNFRSF1B Gene

Molecular function for TNFRSF1B Gene

GENATLAS Biochemistry: tumor necrosis factor receptor superfamily,member 1B,deleted in neuroblastoma,associated with susceptibility to systemic lupus erythematosus
UniProtKB/Swiss-Prot Function: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Gene Ontology (GO) - Molecular Function for TNFRSF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005031 tumor necrosis factor-activated receptor activity IEA --
GO:0005515 protein binding IPI 10848577
GO:0031625 ubiquitin protein ligase binding IPI 11279055
genes like me logo Genes that share ontologies with TNFRSF1B: view
genes like me logo Genes that share phenotypes with TNFRSF1B: view

Animal Models for TNFRSF1B Gene

MGI Knock Outs for TNFRSF1B:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TNFRSF1B Gene

Localization for TNFRSF1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF1B Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Tumor necrosis factor-binding protein 2: Secreted.

Subcellular locations from

Jensen Localization Image for TNFRSF1B Gene COMPARTMENTS Subcellular localization image for TNFRSF1B gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 2
cytoskeleton 1
cytosol 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TNFRSF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF1B: view

Pathways for TNFRSF1B Gene

genes like me logo Genes that share pathways with TNFRSF1B: view

Gene Ontology (GO) - Biological Process for TNFRSF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0007166 cell surface receptor signaling pathway --
GO:0007568 aging IEA --
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA --
genes like me logo Genes that share ontologies with TNFRSF1B: view

Compounds for TNFRSF1B Gene


Pharmaceutical: Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors

(1) Drugbank Compounds for TNFRSF1B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • CD120b
185243-69-0 target

(2) IUPHAR Ligand for TNFRSF1B Gene

Ligand Type Action Affinity Pubmed IDs
lymphotoxin-alpha None None
tumour necrosis factor membrane form None None

(80) Novoseek inferred chemical compound relationships for TNFRSF1B Gene

Compound -log(P) Hits PubMed IDs
etanercept 69.4 29
infliximab 54.4 11
tapi 52.1 2
neopterin 48.3 8
gp 130 41.1 6
genes like me logo Genes that share compounds with TNFRSF1B: view

Transcripts for TNFRSF1B Gene

Unigene Clusters for TNFRSF1B Gene

Tumor necrosis factor receptor superfamily, member 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF1B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - - -
SP3: - -

Relevant External Links for TNFRSF1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF1B Gene

mRNA expression in normal human tissues for TNFRSF1B Gene

mRNA differential expression in normal tissues according to GTEx for TNFRSF1B Gene

This gene is overexpressed in Whole Blood (24.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNFRSF1B Gene

SOURCE GeneReport for Unigene cluster for TNFRSF1B Gene Hs.256278

genes like me logo Genes that share expressions with TNFRSF1B: view

Orthologs for TNFRSF1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFRSF1B 36
  • 96.4 (n)
  • 95.81 (a)
  • 99 (a)
(Bos Taurus)
Mammalia TNFRSF1B 36
  • 78.19 (n)
  • 70.93 (a)
  • 71 (a)
(Canis familiaris)
Mammalia TNFRSF1B 36
  • 79.89 (n)
  • 72.62 (a)
  • 69 (a)
(Mus musculus)
Mammalia Tnfrsf1b 36
  • 74.25 (n)
  • 64.11 (a)
Tnfrsf1b 16
Tnfrsf1b 37
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia TNFRSF1B 37
  • 38 (a)
(Rattus norvegicus)
Mammalia Tnfrsf1b 36
  • 72.65 (n)
  • 62.8 (a)
(Gallus gallus)
Aves TNFRSF1B 36
  • 45.34 (n)
  • 35.78 (a)
  • 34 (a)
(Danio rerio)
Actinopterygii tnfrsf1b 37
  • 26 (a)
Species with no ortholog for TNFRSF1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF1B Gene

Gene Tree for TNFRSF1B (if available)
Gene Tree for TNFRSF1B (if available)

Paralogs for TNFRSF1B Gene

Paralogs for TNFRSF1B Gene

Selected SIMAP similar genes for TNFRSF1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TNFRSF1B: view

Variants for TNFRSF1B Gene

Sequence variations from dbSNP and Humsavar for TNFRSF1B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3397 -- 12,207,235(+) CATGG(C/T)GTGTC utr-variant-3-prime
rs170958 -- 12,197,599(+) ccatt(C/T)ttcct intron-variant
rs189283 -- 12,198,935(-) tggtc(A/C)ccgaa intron-variant
rs189284 -- 12,198,711(-) tcttt(C/T)tcaaa intron-variant
rs235216 -- 12,209,567(+) CCACT(C/T)GGGGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF1B Gene

Variant ID Type Subtype PubMed ID
nsv469830 CNV Complex 16826518
nsv508891 CNV Insertion 20534489
nsv471622 CNV Gain+Loss 15918152
dgv143n71 CNV Gain 21882294
nsv527024 CNV Loss 19592680
nsv870819 CNV Gain 21882294
nsv871005 CNV Gain 21882294
dgv144n71 CNV Loss 21882294
nsv871537 CNV Loss 21882294
nsv871714 CNV Loss 21882294

Relevant External Links for TNFRSF1B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for TNFRSF1B Gene

(93) Novoseek inferred disease relationships for TNFRSF1B Gene

Disease -log(P) Hits PubMed IDs
necrosis 88.9 163
tumors 76.6 169
rheumatoid arthritis 63.4 37
inflammation 48.6 16
arthritis psoriatic 45 4

Relevant External Links for TNFRSF1B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TNFRSF1B: view

No data available for UniProtKB/Swiss-Prot for TNFRSF1B Gene

Publications for TNFRSF1B Gene

  1. New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus. (PMID: 11197692) Tsuchiya N. … Tokunaga K. (Genes Immun. 2000) 3 4 23 49
  2. Association of tumor necrosis factor receptor type II polymorphism 196R with systemic lupus erythematosus in the Japanese: molecular and functional analysis. (PMID: 11762942) Morita C. … Niho Y. (Arthritis Rheum. 2001) 3 4 23 49
  3. Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism. (PMID: 12161545) Peral B. … Escobar-Morreale H.F. (J. Clin. Endocrinol. Metab. 2002) 3 4 23 49
  4. Association between tumor necrosis factor receptor II and familial, but not sporadic, rheumatoid arthritis: evidence for genetic heterogeneity. (PMID: 12209506) DieudAc P. … CornAclis F. (Arthritis Rheum. 2002) 3 23 49
  5. Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis. (PMID: 11961180) Zeggini E. … Donn R. (Rheumatology (Oxford) 2002) 3 23 49

Products for TNFRSF1B Gene

Sources for TNFRSF1B Gene

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