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protein-coding   GIFtS: 71
GCID: GC01P012227

Tumor Necrosis Factor Receptor Superfamily, Member 1B

(Previous symbol: TNFR2)
  See TNFRSF1B-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Tumor Necrosis Factor Receptor Superfamily, Member 1B1 2     TNF-R752
TNFR21 2 3 5     TNFR1B2
TNFBR2 3 5     TNFR802
Tumor Necrosis Factor Receptor 22 3     P75 TNF Receptor2
Tumor Necrosis Factor Receptor Type II2 3     p75TNFR2
TNF-R22 3     Soluble TNFR1B Variant 12
TNF-RII2 3     Tumor Necrosis Factor Beta Receptor2
p752 3     Tumor Necrosis Factor Binding Protein 22
P80 TNF-Alpha Receptor2 3     Tumor Necrosis Factor Receptor Superfamily Member 1B2
CD120b2     Etanercept3
TNF-R-II2     CD120b Antigen3

External Ids:    HGNC: 119171   Entrez Gene: 71332   Ensembl: ENSG000000281377   OMIM: 1911915   UniProtKB: P203333   

Export aliases for TNFRSF1B gene to outside databases

Previous GC identifiers: GC01P012291 GC01P012071 GC01P011836 GC01P011936 GC01P012161 GC01P011380

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF1B Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form
a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3
ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought
to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2,
which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting
neurons from apoptosis by stimulating antioxidative pathways. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFRSF1B Gene:
TNFRSF1B (tumor necrosis factor receptor superfamily, member 1B) is a protein-coding gene. Diseases associated with TNFRSF1B include post-transplant lymphoproliferative disease, and pneumococcal meningitis. GO annotations related to this gene include tumor necrosis factor-activated receptor activity and ubiquitin protein ligase binding. An important paralog of this gene is TNFRSF21.

UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333
Function: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for
homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3
to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks
TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological

Gene Wiki entry for TNFRSF1B Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFRSF1B gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFRSF1B promoter sequence
   Search Chromatin IP Primers for TNFRSF1B

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

TNFRSF1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF1B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P012227:  view genomic region     (about GC identifiers)

12,227,060 bp from pter      End:
12,269,285 bp from pter
42,226 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 1B precursor  
Size: 461 amino acids; 48291 Da
Subunit: Binds to TRAF2. Interacts with BMX
2 PDB 3D structures from and Proteopedia for TNFRSF1B:
1CA9 (3D)        3ALQ (3D)    
Secondary accessions: B1AJZ3 Q16042 Q6YI29 Q9UIH1
Alternative splicing: 2 isoforms:  P20333-1   P20333-2   

Explore the universe of human proteins at neXtProt for TNFRSF1B: NX_P20333

Explore proteomics data for TNFRSF1B at MOPED

Post-translational modifications: 

  • Phosphorylated; mainly on serine residues and with a very low level on threonine residues1
  • A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic
  • Glycosylation2 at Asn171, Asn193, Ser208, Ser221, Thr222
  • Modification sites at PhosphoSitePlus

  • See TNFRSF1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001057.1  
    ENSEMBL proteins: 
     ENSP00000365435   ENSP00000440425  

    TNFRSF1B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TNFRSF1B (TNF RII/TNFRSF1B)
    Enzo Life Sciences proteins for TNFRSF1B
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TNFRSF1B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TNFRSF1B
    GenScript Custom Purified and Recombinant Proteins Services for TNFRSF1B
    Novus Biologicals TNFRSF1B Proteins
    Novus Biologicals TNFRSF1B Lysates
    Sino Biological Recombinant Protein for TNFRSF1B
    Sino Biological Cell Lysate for TNFRSF1B
    ProSpec Recombinant Protein for TNFRSF1B
    Cloud-Clone Corp. Proteins for TNFRSF1B

    Search eBioscience for Proteins for TNFRSF1B 

    antibodies-online proteins for TNFRSF1B (21 products) 

    antibodies-online peptides for TNFRSF1B

    GeneTex Proteins for TNFRSF1B:  
                        Soluble TNF Receptor Type II Recombinant Protein (Active) (GTX48346-PRO)

    TNFRSF1B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TNFRSF1B (TNF RII/TNFRSF1B)
    Cell Signaling Technology (CST) Antibodies for TNFRSF1B  (TNF-R2)
    OriGene Antibodies for TNFRSF1B
    OriGene Custom Antibody Services for TNFRSF1B
    Novus Biologicals TNFRSF1B Antibodies
    Abcam antibodies for TNFRSF1B
    Cloud-Clone Corp. Antibodies for TNFRSF1B
    ThermoFisher Antibodies for TNFRSF1B
    antibodies-online antibodies for TNFRSF1B (147 products) 

    GeneTex Antibodies for TNFRSF1B:  
                        TNFRSF1B Antibodies

    TNFRSF1B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TNFRSF1B
    R&D Systems ELISAs for TNFRSF1B (TNF RII/TNFRSF1B)         (see all)
    GenScript Custom Assay Services for TNFRSF1B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TNFRSF1B
    Cloud-Clone Corp. CLIAs for TNFRSF1B
    eBioscience ELISAs for TNFRSF1B: (see all 2
                        Human sTNF-R (80kDa) Platinum ELISA 96 tests
    antibodies-online kits for TNFRSF1B (19 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    HGNC Gene Families:
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: tumor necrosis factor receptor 2
    Tumour necrosis factor (TNF) receptor family

    2 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR020411 TNFR_1B

    Graphical View of Domain Structure for InterPro Entry P20333

    ProtoNet protein and cluster: P20333

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333
    Similarity: Contains 4 TNFR-Cys repeats

    Find genes that share domains with TNFRSF1B           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR1B_HUMAN, P20333
    Function: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for
    homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3
    to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks
    TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological

         Genatlas biochemistry entry for TNFRSF1B:
    tumor necrosis factor receptor superfamily,member 1B,deleted in neuroblastoma,associated with susceptibility to
    systemic lupus erythematosus

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005031tumor necrosis factor-activated receptor activity IEA--
    GO:0005515protein binding IPI10848577
    GO:0031625ubiquitin protein ligase binding IPI11279055
    Find genes that share ontologies with TNFRSF1B           About GenesLikeMe

         1 GenomeRNAi human phenotype for TNFRSF1B:
     Decreased Hepatitis C virus re 

         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tnfrsf1b) (see all 19):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system  integument 
     liver/biliary system  mortality/aging  muscle  nervous system  renal/urinary system 

    Find genes that share phenotypes with TNFRSF1B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TNFRSF1B: Tnfrsf1btm1Imx Tnfrsf1btm1Mwm

       genOway: Develop your customized and physiologically relevant rodent model for TNFRSF1B

        Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study 

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for TNFRSF1B

    Block miRNA regulation of human, mouse, rat TNFRSF1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNFRSF1B (see all 37):
    hsa-miR-3938 hsa-let-7d hsa-miR-301a hsa-miR-486-3p hsa-let-7g hsa-let-7a hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF1B 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for TNFRSF1B
    Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF1B

    OriGene clones in human, mouse for TNFRSF1B (see all 7)
    OriGene ORF clones in mouse, rat for TNFRSF1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNFRSF1B (NM_001066)
    Sino Biological Human cDNA Clone for TNFRSF1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF1B

    Cell Line
    GenScript Custom overexpressing Cell Line Services for TNFRSF1B
    Browse ESI BIO Cell Lines and PureStem Progenitors for TNFRSF1B 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF1B

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    TNR1B_HUMAN, P20333: Isoform 1: Cell membrane; Single-pass type I membrane protein
    TNR1B_HUMAN, P20333: Isoform 2: Secreted
    TNR1B_HUMAN, P20333: Tumor necrosis factor-binding protein 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    plasma membrane5
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TNFRSF1B           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for TNFRSF1B About   (see all 30)  
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    PGC1Alpha Pathway0.51
    Glucocorticoid Receptor Signaling0.43
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5NF-KappaB Family Pathway
    NF-KappaB (p50-p65) Pathway0.72
    NF-KappaB Family Pathway0.72

    Find genes that share SuperPaths with TNFRSF1B           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for TNFRSF1B
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF1B (see all 28)
        Caspase Cascade
    MAPK Signaling
    THC Differentiation Pathway
    TRAF Pathway
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for TNFRSF1B
        Apoptosis and Autophagy
    NF-kappaB Signaling

    4 GeneGo (Thomson Reuters) Pathways for TNFRSF1B
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival Apoptotic TNF-family pathways
    Transcription NF-kB signaling pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    Selected BioSystems Pathways for TNFRSF1B (see all 6)
    Apoptosis Modulation and Signaling
    TNF-alpha/NF-kB Signaling Pathway
    IL-3 Signaling Pathway
    TNF receptor signaling pathway

    3 Sino Biological Pathways for TNFRSF1B
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    4 Kegg Pathways  (Kegg details for TNFRSF1B):
        Cytokine-cytokine receptor interaction
    TNF signaling pathway
    Adipocytokine signaling pathway
    Amyotrophic lateral sclerosis (ALS)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF1B (see all 12): 
              HIV Host Response in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Multiple Sclerosis in human mouse rat
              Lymphoma in human mouse rat
              Apoptosis in human mouse rat


        GeneGlobe Interaction Network for TNFRSF1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNFRSF1B (P203331, 2, 3 ENSP000003654354) via UniProtKB, MINT, STRING, and/or I2D (see all 155)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206439P013751, 2, 3EBI-358983,EBI-359977 MINT-48048 MINT-49370 I2D: score=10 
    ENSG00000223952P013751, 2, 3EBI-358983,EBI-359977 MINT-48048 MINT-49370 I2D: score=10 
    ENSG00000230108P013751, 2, 3EBI-358983,EBI-359977 MINT-48048 MINT-49370 I2D: score=10 
    ENSG00000204490P013751, 2, 3, ENSP000003652904EBI-358983,EBI-359977 MINT-48048 MINT-49370 I2D: score=10 STRING: ENSP00000365290
    TNFP013751, 2, 3, ENSP000003986984EBI-358983,EBI-359977 MINT-48048 MINT-49370 I2D: score=10 STRING: ENSP00000398698
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process ----
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007568aging IEA--

    Find genes that share ontologies with TNFRSF1B           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFRSF1B (TNR1B)

    UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333
    Pharmaceutical: Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe
    rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an
    immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors

    1 DrugBank Compound for TNFRSF1B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    EtanerceptCD120b (see all 7)185243-69-0target--11752352

    2 IUPHAR Ligands for TNFRSF1B (tumor necrosis factor receptor 2)    About this table
    LigandTypeActionAffinityPubmed IDs
    tumour necrosis factor membrane form

    Selected Novoseek inferred chemical compound relationships for TNFRSF1B gene (see all 80)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    etanercept 69.4 34 11574988 (1), 12110156 (1), 16796629 (1), 10904249 (1) (see all 29)
    infliximab 54.4 13 19370184 (2), 12110156 (1), 19136378 (1), 12421092 (1) (see all 10)
    tapi 52.1 4 7869036 (2)
    neopterin 48.3 9 9764776 (2), 15642275 (2), 16273760 (1), 10973464 (1) (see all 6)
    gp 130 41.1 7 10575186 (2), 19631179 (1), 19107325 (1), 10414448 (1) (see all 5)
    il 10 29.6 9 12011375 (3), 8891726 (1), 11508666 (1), 19186969 (1)
    fmlp 29.4 8 7998940 (3), 8946217 (1), 9886420 (1)
    endotoxin 27.9 5 1322942 (1), 7622886 (1), 17244513 (1), 9185243 (1) (see all 5)
    rantes 26.8 8 11562425 (2), 11504986 (2), 10843668 (1), 12376864 (1) (see all 6)
    cuprophan 25.7 2 16988495 (1), 11509797 (1)

    Find genes that share compounds with TNFRSF1B           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for TNFRSF1B gene: 

    Unigene Cluster for TNFRSF1B:

    Tumor necrosis factor receptor superfamily, member 1B
    Hs.256278  [show with all ESTs]
    Unigene Representative Sequence: BC052977
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376259(uc001att.3 uc009vnk.3) ENST00000492361(uc001atu.3)
    ENST00000489921 ENST00000536782
    Block miRNA regulation of human, mouse, rat TNFRSF1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNFRSF1B (see all 37):
    hsa-miR-3938 hsa-let-7d hsa-miR-301a hsa-miR-486-3p hsa-let-7g hsa-let-7a hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF1B 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for TNFRSF1B
    Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF1B
    OriGene clones in human, mouse for TNFRSF1B (see all 7)
    OriGene ORF clones in mouse, rat for TNFRSF1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNFRSF1B (NM_001066)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF1B
    OriGene qPCR primer pairs and template standards for TNFRSF1B
    OriGene qSTAR qPCR primer pairs in human, mouse for TNFRSF1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNFRSF1B
      QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF1B
      QuantiFast Probe-based Assays in human, mouse, rat TNFRSF1B

    Additional mRNA sequence: 

    AY148473.1 BC011844.2 BC042167.1 BC052977.1 BT019927.1 EU826615.1 M32315.1 M35857.1 
    M55994.1 S63368.1 

    7 DOTS entries:

    DT.415651  DT.100823263  DT.100823260  DT.95169202  DT.100823259  DT.100823262  DT.101984571 

    Selected AceView cDNA sequences (see all 183):

    AA533208 AI422018 CA435681 AW170706 AW468069 AA972749 BE466601 H26148 
    AI985195 BC011844 NM_001066 BQ690571 AI360418 CD610466 CD610462 BQ632532 
    BF222736 AI659001 BU158001 AI140025 T78122 AI632561 BE138861 AI762184 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF1B    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                -                                                         
    SP2:                                -                             -     -                     
    SP3:                          -     -                                                         

    ECgene alternative splicing isoforms for TNFRSF1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFRSF1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    TNFRSF1B Expression
    About this image

    TNFRSF1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
    TNFRSF1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFRSF1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.256278
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF1B (see all 12): 
              HIV Host Response in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Multiple Sclerosis in human mouse rat
              Lymphoma in human mouse rat
              Apoptosis in human mouse rat

    OriGene qPCR primer pairs and template standards for TNFRSF1B
    OriGene qSTAR qPCR primer pairs in human, mouse for TNFRSF1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNFRSF1B
    QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF1B
    QuantiFast Probe-based Assays in human, mouse, rat TNFRSF1B
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF1B gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Tnfrsf1b1 , 5 tumor necrosis factor receptor superfamily, member more1, 5 74.25(n)1
      4 (78.17 cM)5
    219381  NM_011610.31  NP_035740.21 
    (Gallus gallus)
    Aves TNFRSF1B1 tumor necrosis factor receptor superfamily, member more 45.34(n)
      395083  NM_204439.3  NP_989770.2 
    (Danio rerio)
    Actinopterygii tnfrsf1b6
    tumor necrosis factor receptor superfamily, member...
    1 ↔ 1
    11(41910114-41933153) ENSDARG00000070165

    ENSEMBL Gene Tree for TNFRSF1B (if available)
    TreeFam Gene Tree for TNFRSF1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for TNFRSF1B gene
    3 SIMAP similar genes for TNFRSF1B using alignment to 2 protein entries:     TNR1B_HUMAN (see all proteins):
    TNFR1B    CD40    TNFRSF6B

    Find genes that share paralogs with TNFRSF1B           About GenesLikeMe

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    Selected SNPs for TNFRSF1B (see all 1124)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 1 posSequence#AA
    C--11396922(+) TATCT-/ATC   
    1 -- int10--------
    --11396963(+) TTATC-/TATTT 
    1 -- int10--------
    C,F--11401495(+) TCACATG/-AGTGT 1 -- int14Minor allele frequency- -:0.09NS CSA 244
    C--11410251(+) TTTTTT/-CTTTC 1 -- int11Minor allele frequency- -:0.00CSA 2
    C,F--11415953(+) CTACTG/AATAAT 1 -- int18Minor allele frequency- A:0.15NS NA WA EA 630
    C,F,H--11415954(+) TACTGA/CTAATT 1 -- int19Minor allele frequency- C:0.18NS EA NA 664
    C,F--12229032(+) TCCCCC/-GCCTC 1 -- int12Minor allele frequency- -:0.11NS 88
    C,F--12230234(+) CATTCATTC/-  
    1 -- int12Minor allele frequency- -:0.22NS 94
    F--12234229(+) CTTCTC/TCTTCT 1 -- int11Minor allele frequency- T:0.50NA 2
    F--12234235(+) CTTCTC/TCTTCT 1 -- int11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for TNFRSF1B (12227060 - 12269285 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for TNFRSF1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508891CNV Insertion20534489
    nsv871537CNV Loss21882294
    nsv527024CNV Loss19592680
    nsv871714CNV Loss21882294
    dgv144n71CNV Loss21882294
    dgv143n71CNV Gain21882294
    nsv871005CNV Gain21882294
    nsv870819CNV Gain21882294
    nsv471622CNV Gain+Loss15918152
    nsv469830CNV Complex16826518

    Human Gene Mutation Database (HGMD): TNFRSF1B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFRSF1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 191191    OMIM disorders: --

    14 diseases for TNFRSF1B:    
    About MalaCards
    post-transplant lymphoproliferative disease    pneumococcal meningitis    palindromic rheumatism    exanthem
    guillain-barre syndrome    connective tissue disease    schizophrenia    narcolepsy
    spondylitis    behcet's disease    mixed connective tissue disease    rheumatoid arthritis
    insulin resistance    malaria

    18 inferred disease relationships from the University of Copenhagen DISEASES database for TNFRSF1B:
    Rheumatoid arthritis     Psoriasis     Psoriatic arthritis     Ankylosing spondylitis
    Crohn's disease     Tuberculosis     Hypersensitivity reaction type II disease     Vasculitis
    Uveitis     Arthropathy     Dermatitis     Synovitis
    Exanthem     Hidradenitis suppurativa     Sarcoidosis     adult-onset Still's disease
    Pneumonia     Myositis

    Find genes that share disorders with TNFRSF1B           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TNFRSF1B gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 88.9 718 7573266 (5), 10561634 (4), 1324217 (3), 1655619 (2) (see all 99)
    tumors 76.6 638 7573266 (5), 9669810 (4), 10561634 (4), 9677439 (3) (see all 99)
    rheumatoid arthritis 63.4 46 9290265 (3), 10765919 (2), 15022314 (2), 15603867 (2) (see all 30)
    inflammation 48.6 18 19343543 (1), 18848768 (1), 11156356 (1), 16947419 (1) (see all 16)
    arthritis psoriatic 45 6 17502870 (1), 19222252 (1), 17394851 (1), 12011375 (1)
    spondylitis ankylosing 43.4 4 19177266 (1), 11986408 (1), 17502870 (1), 17394851 (1)
    fibroma shope 43.3 1 8590321 (1)
    lupus erythematosus systemic 35.6 35 12739039 (3), 11762942 (2), 15642275 (2), 11197692 (2) (see all 18)
    autoimmune diseases 32.2 7 11169260 (4), 17785864 (1), 20225650 (1), 10436260 (1)
    shock septic 31 4 8627066 (1), 11084543 (1), 11253333 (1), 15526005 (1)

    Genetic Association Database (GAD): TNFRSF1B
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF1B (154 documents)

    Export disorders for TNFRSF1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFRSF1B gene, integrated from 10 sources (see all 863) (see top 10):
    (articles sorted by number of sources associating them with TNFRSF1B)

    1. Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism. (PubMed id 12161545)1, 2, 4, 9 Peral B....Escobar-Morreale H.F. (J. Clin. Endocrinol. Metab. 2002)
    2. Association of tumor necrosis factor receptor type II polymorphism 196R with systemic lupus erythematosus in the Japanese: molecular and functional analysis. (PubMed id 11762942)1, 2, 4, 9 Morita C.... Niho Y. (Arthritis Rheum. 2001)
    3. New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus. (PubMed id 11197692)1, 2, 4, 9 Tsuchiya N.... Tokunaga K. (Genes Immun. 2000)
    4. Bone structural effects of variation in the TNFRSF1B gene encoding the tumor necrosis factor receptor 2. (PubMed id 18038243)1, 4, 9 Mullin B.H....Wilson S.G. (Osteoporos Int 2008)
    5. The biallelic variable number of tandem repeats of the tumor necrosis factor receptor 2 promoter in systemic lupus erythematosus. (PubMed id 12739039)1, 4, 9 Lee Y.H....Song G.G. (Rheumatol. Int. 2003)
    6. Tumor necrosis factor receptor 2 gene (TNFRSF1B) in genetic basis of coronary artery disease. (PubMed id 11357933)1, 4, 9 Benjafield A.V....Morris B.J. (J. Mol. Med. 2001)
    7. A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: a case-control study and a meta-analysis. (PubMed id 17028114)1, 4, 9 Horiuchi T....Harada M. (Ann. Rheum. Dis. 2007)
    8. Association between TNFRSF1B polymorphisms and bone mineral density, bone loss and fracture. (PubMed id 15071724)1, 4, 9 Tasker P.N....Ralston S.H. (Osteoporos Int 2004)
    9. Single nucleotide polymorphisms in TNF-alpha, TNFR2 gene and TNF-alpha production in Asian Indians. (PubMed id 19811435)1, 4, 9 Gupta R....Das S.N. (Immunol. Invest. 2009)
    10. Polymorphisms of the tumor necrosis factor-alpha receptor 2 gene are associated with obesity phenotypes among 405 Caucasian nuclear families. (PubMed id 18685868)1, 4, 9 Zhao L.J....Deng H.W. (Hum. Genet. 2008)
    11. No association with hypertension of CLCNKB and TNFRSF1B polymorphisms at a hypertension locus on chromosome 1p36. (PubMed id 16003175)1, 4, 9 Speirs H.J....Morris B.J. (J. Hypertens. 2005)
    12. A functional polymorphism of the tumor necrosis factor receptor-II gene associated with the survival and relapse prediction of breast carcinoma. (PubMed id 15863392)1, 4, 9 Mestiri S....Chouchane L. (Cytokine 2005)
    13. Association of polymorphisms of the tumour necrosis factor receptors I and II and rheumatoid arthritis. (PubMed id 12730509)1, 4, 9 Bayley J.P....Verweij C.L. (Rheumatology (Oxford) 2003)
    14. Polymorphisms in TNFA and TNFR2 affect outcome of unrelated bone marrow transplantation. (PubMed id 11979305)1, 4, 9 Ishikawa Y....Juji T. (Bone Marrow Transplant. 2002)
    15. Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design. (PubMed id 19557004)1, 4, 9 Eguchi T....Saruta T. (Hypertens. Res. 2009)
    16. -238 and +489 TNF-alpha along with TNF-RII gene polymorphisms associate with the diffuse phenotype in patients with Systemic Sclerosis. (PubMed id 15585313)1, 4, 9 Tolusso B....Ferraccioli G. (Immunol. Lett. 2005)
    17. Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis. (PubMed id 16277675)1, 4, 9 Glossop J.R....Mattey D.L. (amp 2005)
    18. Relationship between the tumor necrosis factor receptor II (TNF-RII) gene polymorphism and sTNF-RII plasma levels in healthy controls and in rheumatoid arthritis. (PubMed id 15603867)1, 4, 9 Tolusso B....Ferraccioli G.F. (Hum. Immunol. 2004)
    19. Physical mapping and genomic structure of the human TNFR2 gene. (PubMed id 8661109)1, 2, 9 Beltinger C.P....Brodeur G.M. (Genomics 1996)
    20. The role of tumor necrosis factor (TNF)-alpha and TNF receptor polymorphisms in susceptibility to ankylosing spondylitis. (PubMed id 19772798)1, 4, 9 Chatzikyriakidou A....Drosos A.A. (Clin. Exp. Rheumatol. 2009)
    21. A potential role of TNFR gene polymorphisms in autoimmune thyroid diseases in the Tunisian population. (PubMed id 18571427)1, 4, 9 Kammoun-Krichen M....Ayadi H. (Cytokine 2008)
    22. Association analysis of TNFRSF1B polymorphisms with type 2 diabetes and its related traits in North India. (PubMed id 19343543)1, 4, 9 Tabassum R....Bharadwaj D. (Genomic Med 2008)
    23. Linkage and association between CA repeat polymorphism of the TNFR2 gene and obesity phenotypes in two independent Caucasian populations. (PubMed id 16980123)1, 4, 9 Huang Q.Y....Deng H.W. (Yi Chuan Xue Bao 2006)
    24. Anemia in rheumatoid arthritis: association with polymorphism in the tumor necrosis factor receptor I and II genes. (PubMed id 16142859)1, 4, 9 Glossop J.R....Mattey D.L. (J. Rheumatol. 2005)
    25. Tumor necrosis factor receptor gene polymorphisms in Crohn's disease: association with clinical phenotypes. (PubMed id 15842589)1, 4, 9 Waschke K.A....Wild G.E. (Am. J. Gastroenterol. 2005)
    26. TNFR2 gene polymorphism in coronary artery disease. (PubMed id 15805680)1, 4, 9 Sankar V.H....Agrawal S. (Indian J Med Sci 2005)
    27. [Potential effect of tumor necrosis factor-alpha and tumor necrosis factor receptor II gene polymorphisms on the pathogenesis of silicosis]. (PubMed id 15555301)1, 4, 9 Li L....Liu B.C. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2004)
    28. [Potential effect of tumor necrosis factor-alpha and its receptor II gene polymorphisms on the pathogenesis of coal worker's pneumoconiosis]. (PubMed id 15355698)1, 4, 9 Li L....Wang H.L. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2004)
    29. Tumour necrosis factor-alpha polymorphism and the HLA-Cw*0602 allele in psoriatic arthritis. (PubMed id 12011375)1, 4, 9 Al-Heresh A.M....McHugh N. (Rheumatology (Oxford) 2002)
    30. Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis. (PubMed id 12370298)1, 2, 9 Pan S.... Min W. (Mol. Cell. Biol. 2002)
    31. Tumor necrosis factor receptor 2 polymorphism in systemic lupus erythematosus: no association with disease. (PubMed id 11600223)1, 4, 9 Lee E.B....Song Y.W. (Hum. Immunol. 2001)
    32. Association between rheumatoid arthritis and polymorphism of tumor necrosis factor receptor II, but not tumor necrosis factor receptor I, in Caucasians. (PubMed id 11212177)1, 4, 9 Barton A....Worthington J. (Arthritis Rheum. 2001)
    33. Tumor necrosis factor receptor-II: heritability and effect on brain morphology in schizophrenia. (PubMed id 11126399)1, 4, 9 Wassink T.H....Andreasen N.C. (Mol. Psychiatry 2000)
    34. Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation. (PubMed id 1328224)1, 2, 9 Pennica D.... Goeddel D.V. (J. Biol. Chem. 1992)
    35. Polymorphism of interleukin-10 promoter and tumor necrosis factor receptor II in Vietnamese patients with systemic lupus erythematosus. (PubMed id 15674653)1, 4, 9 Khoa P.D....Yokochi T. (Clin. Rheumatol. 2005)
    36. Tumor necrosis factor receptor II gene polymorphism and severity of rheumatoid arthritis. (PubMed id 15022314)1, 4, 9 Constantin A....Cantagrel A. (Arthritis Rheum. 2004)
    37. Genetic contribution of tumor necrosis factor (TNF)-alpha gene promoter (-1031, -863 and -857) and TNF receptor 2 gene polymorphisms in endometriosis susceptibility. (PubMed id 15212671)1, 4, 9 Teramoto M....Honjo H. (Am. J. Reprod. Immunol. 2004)
    38. Association of tumor necrosis factor receptor type 2 +587 gene polymorphism with severe chronic periodontitis. (PubMed id 15142217)1, 4, 9 Shimada Y....Yamazaki K. (J. Clin. Periodontol. 2004)
    39. No association between tumour necrosis factor receptor type 2 gene polymorphism and rheumatoid arthritis severity: a comparison of the extremes of phenotypes. (PubMed id 15252214)1, 4, 9 van der Helm-van Mil A.H....Huizinga T.W. (Rheumatology (Oxford) 2004)
    40. Tumor necrosis factor receptor 2 microsatellite and exon 6 polymorphisms in rheumatoid arthritis in Taiwan. (PubMed id 12610797)1, 4, 9 Yen J.H....Liu H.W. (J. Rheumatol. 2003)
    41. Association between tumor necrosis factor receptor II and familial, but not sporadic, rheumatoid arthritis: evidence for genetic heterogeneity. (PubMed id 12209506)1, 4, 9 DieudAc P....CornAclis F. (Arthritis Rheum. 2002)
    42. TNFRSF1B in genetic predisposition to clinical neuropathy and effect on HDL cholesterol and glycosylated hemoglobin in type 2 diabetes. (PubMed id 11315843)1, 4, 9 Benjafield A.V....Morris B.J. (Diabetes Care 2001)
    43. Analysis of tumor necrosis factor-alpha, lymphotoxin-alpha, tumor necrosis factor receptor II, and interleukin-6 polymorphisms in patients with idiopathic pulmonary fibrosis. (PubMed id 11371414)1, 4, 9 Pantelidis P....Du Bois R.M. (Am. J. Respir. Crit. Care Med. 2001)
    44. Tumor necrosis factor, tumor necrosis factor receptors type 1 and 2, lymphotoxin-alpha, and HLA-DRB1 gene polymorphisms in human T-cell lymphotropic virus type I associated myelopathy. (PubMed id 11163081)1, 4, 9 Nishimura M....Uchiyama T. (Hum. Immunol. 2000)
    45. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. (PubMed id 8069916)1, 2, 9 Rothe M.... Goeddel D.V. (Cell 1994)
    46. A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations. (PubMed id 20007930)1, 4, 9 MAPller M....Franke A. (Am. J. Respir. Crit. Care Med. 2010)
    47. Polymorphisms spanning the TNFR2 and TACE genes do not contribute towards variable anti-TNF treatment response. (PubMed id 20300049)1, 4, 9 Potter C....Barton A. (Pharmacogenet. Genomics 2010)
    48. Cigarette smoking, STAT4 and TNFRSF1B polymorphisms, and systemic lupus erythematosus in a Japanese population. (PubMed id 19684152)1, 4, 9 Kiyohara C....Takahashi H. (J. Rheumatol. 2009)
    49. Tumor necrosis factor (TNF)-TNF receptor gene polymorphisms and their serum levels in Korean women with endometriosis. (PubMed id 19238748)1, 4, 9 Chae S.J....Kim J.G. (Am. J. Reprod. Immunol. 2008)
    50. Influence of FCGR3A-V212F and TNFRSF1B-M196R genotypes in patients with rheumatoid arthritis treated with infliximab therapy. (PubMed id 18565259)1, 4, 9 Rooryck C....Schaeverbeke T. (Clin. Exp. Rheumatol. 2008)
    51. Association of TNF-alpha and TNFR1 promoters and 3' UTR region of TNFR2 gene polymorphisms with genetic susceptibility to tobacco-related oral carcinoma in Asian Indians. (PubMed id 18206417)1, 4, 9 Gupta R....Das S.N. (Oral Oncol. 2008)
    52. Variable number of tandem repeats of TNF receptor type 2 promoter as genetic biomarker of susceptibility to develop invasive pulmonary aspergillosis. (PubMed id 17207711)1, 4, 9 Sainz J....Jurado M. (Hum. Immunol. 2007)
    53. Tumor necrosis factor receptor 2 M196R polymorphism in rheumatoid arthritis and osteoarthritis: relationship with sTNFR2 levels and clinical features. (PubMed id 16871413)1, 4, 9 OregA^n-Romero E....MuA+oz-Valle J.F. (Rheumatol. Int. 2006)
    54. Tumour necrosis factor receptors (TNFRs) in Type 2 diabetes. Analysis of soluble plasma fractions and genetic variations of TNFR2 gene in a case-control study. (PubMed id 15787661)1, 4, 9 Vendrell J....Richart C. (Diabet. Med. 2005)
    55. Tumour necrosis factor-alpha receptor 1 and 2 polymorphisms in inflammatory bowel disease and their association with response to infliximab. (PubMed id 15274667)1, 4, 9 Pierik M....Rutgeerts P. (amp 2004)
    56. A TNFR1 genotype with a protective role in familial rheumatoid arthritis. (PubMed id 14872483)1, 4, 9 DieudAc P....CornAclis F. (Arthritis Rheum. 2004)
    57. TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study. (PubMed id 15526005)1, 4, 9 Gordon A.C....Hinds C.J. (Genes Immun. 2004)
    58. Genetic variants in the tumor necrosis factor receptor II gene in patients with multiple sclerosis. (PubMed id 14651520)1, 4, 9 Ehling R....Berger T. (Tissue Antigens 2004)
    59. The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. (PubMed id 15457442)1, 4, 9 Criswell L.A....Bridges S.L. (Arthritis Rheum. 2004)
    60. Polymorphisms of the tumor necrosis factor receptors: no association with narcolepsy in German patients. (PubMed id 12601524)1, 4, 9 Wieczorek S....Gencik M. (J. Mol. Med. 2003)
    61. TNF and TNF receptor polymorphisms in Korean Behcet's disease patients. (PubMed id 12770792)1, 4, 9 Lee E.B....Song Y.W. (Hum. Immunol. 2003)
    62. No association of polymorphisms in the tumor necrosis factor receptor I and receptor II genes with disease severity in rheumatoid arthritis. (PubMed id 12858434)1, 4, 9 Glossop J.R....Mattey D.L. (J. Rheumatol. 2003)
    63. Tumour necrosis factor receptor type II 196M/R genotype correlates with circulating soluble receptor levels in normal subjects and with graft-versus-host disease after sibling allogeneic bone marrow transplantation. (PubMed id 14688526)1, 4, 9 Stark G.L....Middleton P.G. (Transplantation 2003)
    64. Association analysis of bone mineral density and single nucleotide polymorphisms in two candidate genes on chromosome 1p36. (PubMed id 14565595)1, 4, 9 Spotila L.D....Devoto M. (Calcif. Tissue Int. 2003)
    65. Tumor necrosis factor-alpha receptor II polymorphism in patients from southern Europe with mild-moderate and severe rheumatoid arthritis. (PubMed id 12233877)1, 4, 9 Fabris M....Ferraccioli G. (J. Rheumatol. 2002)
    66. Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis. (PubMed id 11961180)1, 4, 9 Zeggini E....Donn R. (Rheumatology (Oxford) 2002)
    67. Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese. (PubMed id 11169260)1, 4, 9 Takahashi M....Kimura A. (Tissue Antigens 2001)
    68. Case-control study with narcoleptic patients and healthy controls who, like the patients, possess both HLA-DRB1*1501 and -DQB1*0602. (PubMed id 11285131)1, 4, 9 Hohjoh H....Tokunaga K. (Tissue Antigens 2001)
    69. Structural basis for self-association and receptor recognition of human TRAF2. (PubMed id 10206649)1, 2, 9 Park Y.C.... Wu H. (Nature 1999)
    70. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    71. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. (PubMed id 20811626)1, 4 Hildebrandt M.A....Wu X. (PLoS ONE 2010)
    72. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    73. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    74. Lack of association between tumour necrosis factor receptor types 1 and 2 gene polymorphism and severe acute alcoholic hepatitis. (PubMed id 19641466)1, 4 Nguyen-Khac E....Naassila M. (amp 2010)
    75. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    76. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    77. TNFRSF1B A1466G genotype is predictive of clinical efficacy after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma. (PubMed id 20646319)1, 4 Kuwahara A....Sakaeda T. (amp 2010)
    78. SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine. (PubMed id 20217072)1, 4 Dhiman N....Poland G.A. (Immunogenetics 2010)
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    209. TNF receptor 2 protects oligodendrocyte progenitor cells against oxidative stress. (PubMed id 24076392)1 Maier O....Pfizenmaier K. (Biochem. Biophys. Res. Commun. 2013)
    210. Quantitative flow cytometric analysis of expression of tumor necrosis factor receptor types I and II on mononuclear cells. (PubMed id 23316846)1 Lopatnikova J.A....Sennikov S.V. (J. Recept. Signal Transduct. Res. 2013)
    211. Amyloid betaa88a88a88a88 (AI^a88a88) up-regulates the expression of sortilin via the p75(NTR)/RhoA signaling pathway. (PubMed id 23895422)1 Saadipour K....Zhou X.F. (J. Neurochem. 2013)
    212. Overexpression of TNF-I+ in mitochondrial diseases caused by mutations in mtDNA: evidence for signaling through its receptors on mitochondria. (PubMed id 23619127)1 Vattemi G....Tomelleri G. (amp 2013)
    213. Levels of TNF-I+, soluble TNF receptors (sTNFR1, sTNFR2), and cognition in bipolar disorder. (PubMed id 23532748)1 Doganavsargil-Baysal O....Davran F. (Hum Psychopharmacol 2013)
    214. Release of nonmuscle myosin II from the cytosolic domain of tumor necrosis factor receptor 2 is required for target gene expression. (PubMed id 23861542)1 Chandrasekharan U.M....DiCorleto P.E. (Sci Signal 2013)
    215. Association analysis of TNFRSF1B polymorphism with susceptibility for migraine in the Chinese Han population. (PubMed id 22342236)1 Dong W....Ni J. (J Clin Neurosci 2012)
    216. Association of TNFI+, TNFR1, and TNFR2 polymorphisms with sperm concentration and motility. (PubMed id 21350240)1 Lazaros L.A....Georgiou I.A. (J. Androl. 2012)
    217. Genetic polymorphisms in TNFA/TNFR2 genes and Chagas disease in a Colombian endemic population. (PubMed id 22221522)1 Criado L....GonzA!lez C.I. (Cytokine 2012)
    218. Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease. (PubMed id 22860894)1 Steenholdt C....Bendtzen K. (amp 2012)
    219. [TNF-I+ and soluble receptor TNF-I+ type 1 in children with diabetes mellitus type 1]. (PubMed id 22525685)1 Szalecki M....Janas R. (Pediatr Endocrinol Diabetes Metab 2012)
    220. Increased tumor necrosis factor receptor 1 expression in human colorectal adenomas. (PubMed id 23082052)1 Hosono K....Nakajima A. (World J. Gastroenterol. 2012)
    221. Distribution of P75 neurotrophin receptor in adult human cochlea--an immunohistochemical study. (PubMed id 22461090)1 Liu W....Rask-Andersen H. (Cell Tissue Res. 2012)
    222. Both internalization and AIP1 association are required for tumor necrosis factor receptor 2-mediated JNK signaling. (PubMed id 22743059)1 Ji W....Min W. (Arterioscler. Thromb. Vasc. Biol. 2012)
    223. The methionine 196 arginine polymorphism of the TNF receptor 2 gene (TNFRSF1B) is not associated with worse outcomes in heart failure. (PubMed id 22921902)1 McTiernan C.F....McNamara D. (Cytokine 2012)
    224. Arecoline-induced death of human leukemia K562 cells is associated with surface up-modulation of TNFR2. (PubMed id 21809341)1 Chen Y.J. and Chang L.S. (J. Cell. Physiol. 2012)
    225. Hippocampal membrane-associated p75NTR levels are increased in Alzheimer's disease. (PubMed id 22451321)1 Chakravarthy B....Whitfield J. (J. Alzheimers Dis. 2012)
    226. Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort. (PubMed id 22617158)1 Grote V.A....HalkjA ( 2012)
    227. The tumor necrosis factor receptor stalk regions define responsiveness to soluble versus membrane-bound ligand. (PubMed id 22547679)1 Richter C....Krippner-Heidenreich A. (Mol. Cell. Biol. 2012)
    228. Circulating levels of TNF receptor II are prognostic for patients with peripheral T-cell non-Hodgkin lymphoma. (PubMed id 22573350)1 Heemann C....Kube D. (Clin. Cancer Res. 2012)
    229. Tumour necrosis factor alpha and oxidative stress as maintaining factors in the evolution of anorexia nervosa. (PubMed id 23086255)1 Agnello E....Palmo A. (Eat Weight Disord 2012)
    230. Effect of aerobic training on plasma cytokines and soluble receptors in elderly women with knee osteoarthritis, in response to acute exercise. (PubMed id 22215119)1 Gomes W.F....Brito-Melo G.E. (Clin. Rheumatol. 2012)
    231. A positive correlation between hydrogen peroxide and soluble TNF-alpha receptor 2 early in maternal blood and at term in placenta of pregnant women with preeclampsia. (PubMed id 21174572)1 Leblanc S....Aris A. (Hypertens Pregnancy 2012)
    232. Salivary cortisol and soluble tumor necrosis factor-I+ receptor II responses to multiple experimental modalities of acute pain. (PubMed id 21895688)1 Goodin B.R....McGuire L. (Psychophysiology 2012)
    233. Myometrial tumor necrosis factor-I+ receptors increase with gestation and labor and modulate gene expression through mitogen-activated kinase and nuclear factor-I_B. (PubMed id 22228740)1 Alexander H.A....Johnson M.R. (Reprod Sci 2012)
    234. NF-kappaB signal triggering and termination by tumor necrosis factor receptor 2. (PubMed id 21558270)1 RodrA-guez M....Lazo P.S. (J. Biol. Chem. 2011)
    235. TNFR2 - target for therapeutics against neurodegenerative diseases? (PubMed id 21153362)1 Nijholt I.M....Eisel U.L. (Adv. Exp. Med. Biol. 2011)
    236. Tumor necrosis factor-I+ signaling via TNFR1/p55 is deleterious whereas TNFR2/p75 signaling is protective in adult infarct myocardium. (PubMed id 21153348)1 Kishore R....Goukassian D.A. (Adv. Exp. Med. Biol. 2011)
    237. TNFR2 interposes the proliferative and NF-I_B-mediated inflammatory response by podocytes to TNF-I+. (PubMed id 21221075)1 Bruggeman L.A....Nelson P.J. ( a journal of technical methods and pathology 2011)
    238. TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms. (PubMed id 21850048)1 Rauert H....Siegmund D. (amp 2011)
    239. Lower frequency of CD62L(high) and higher frequency of TNFR2(+) Tregs are associated with inflammatory conditions in type 1 diabetic patients. (PubMed id 21584225)1 Ryba M....MyA9liwska J. (Mediators Inflamm. 2011)
    240. A TNF receptor 2 selective agonist rescues human neurons from oxidative stress-induced cell death. (PubMed id 22110694)1 Fischer R....Pfizenmaier K. (PLoS ONE 2011)
    241. Necdin and neurotrophin receptors: interactors of relevance for neuronal resistance to oxidant stress. (PubMed id 21150695)1 Ingraham C.A....Schor N.F. (Pediatr. Res. 2011)
    242. The effect of P75 on Trk receptors in neuroblastomas. (PubMed id 21419569)1 Ho R....Brodeur G.M. (Cancer Lett. 2011)
    243. Association of the Met-196-Arg variation of human tumor necrosis factor receptor 2 (TNFR2) with paranoid schizophrenia. (PubMed id 20842464)1 Thabet S....Jrad B.B. (J. Mol. Neurosci. 2011)
    244. Relationship between TNFA, TNFB and TNFRII gene polymorphisms and outcome after unrelated hematopoietic cell transplantation in a Chinese population. (PubMed id 20548340)1 Xiao H.W....Huang H. (Bone Marrow Transplant. 2011)
    245. Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom. (PubMed id 20401725)1 Ghelani A.M....Mastana S.S. (Rheumatol. Int. 2011)
    246. TNFRSF1B +676 T&gt;G polymorphism predicts survival of non-small cell lung cancer patients treated with chemoradiotherapy. (PubMed id 21995493)1 Guan X....Wei Q. (BMC Cancer 2011)
    247. Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells. (PubMed id 21994466)1 Hamilton K.E....Lund P.K. (Mol. Cancer Res. 2011)
    248. Evaluation of serum level of tumor necrosis factor receptor II in hepatitis C virus (genotype 4)-infected middle-aged men with and without diabetes and its complications in Egypt: a pilot study. (PubMed id 22068019)1 Said E.S....Mosaad N.A. (J. Investig. Med. 2011)
    249. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. (PubMed id 21393509)1 Tang W....Liu C.J. (Science 2011)
    250. Polymorphism of 3'UTR region of TNFR2 coding gene and its role in clinical tuberculosis in Han Chinese pediatric population. (PubMed id 21554999)1 Mokrousov I....Shen A. (Infect. Genet. Evol. 2011)
    251. Tumor necrosis factor-I+ levels correlate with postoperative pain severity in lumbar disc hernia patients: opposite clinical effects between tumor necrosis factor receptor 1 and 2. (PubMed id 21920667)1 Andrade P....Hoogland G. (Pain 2011)
    252. Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis. (PubMed id 21523796)1 Tarrats N....MarA- M. (Hepatology 2011)
    253. Human lymphatic filariasis: genetic polymorphism of endothelin-1 and tumor necrosis factor receptor II correlates with development of chronic disease. (PubMed id 21673044)1 Panda A.K....Satapathy A.K. (J. Infect. Dis. 2011)
    254. Association of tumor necrosis factor alpha and its receptor polymorphisms with rheumatoid arthritis in female patients. (PubMed id 21777909)1 Hussein Y.M....Alzahrani S.S. (Cell. Immunol. 2011)
    255. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    256. No association of TNFRSF1B variants with type 2 diabetes in Indians of Indo-European origin. (PubMed id 21849023)1 Tabassum R....Bharadwaj D. (BMC Med. Genet. 2011)
    257. Association between serum soluble TNFI+ receptors and renal dysfunction in type 2 diabetic patients without proteinuria. (PubMed id 21288590)1 Miyazawa I....Maegawa H. (Diabetes Res. Clin. Pract. 2011)
    258. Association of anti-CCP positivity and carriage of TNFRII susceptibility variant with anti-TNF-I+ response in rheumatoid arthritis. (PubMed id 21813066)1 Vasilopoulos Y....Mamouris Z. (Clin. Exp. Rheumatol. 2011)
    259. Tumor necrosis factor-receptor 2 and TROY gene expression patterns in cutaneous squamous cell carcinoma in a Tunisian population. (PubMed id 22057614)1 Zidi I.T....Nouira R.B. (Saudi Med J 2011)
    260. TNFR 2 M196R polymorphism and acne vulgaris in Han Chinese: a case-control study. (PubMed id 20556591)1 Tian L....Wang W. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2010)
    261. Soluble TNF receptors are associated with AI^ metabolism and conversion to dementia in subjects with mild cognitive impairment. (PubMed id 19070941)1 Buchhave P....Hansson O. (Neurobiol. Aging 2010)
    262. Plasma soluble tumour necrosis factor-alpha receptor 2 is elevated in obesity: specific contribution of visceral adiposity. (PubMed id 19650780)1 Cartier A....DesprAcs J.P. (Clin. Endocrinol. (Oxf) 2010)
    263. Altered expression of TNF-alpha signaling pathway proteins in systemic lupus erythematosus. (PubMed id 20516030)1 Zhu L.J....Wither J.E. (J. Rheumatol. 2010)
    264. Endothelial-specific transgenesis of TNFR2 promotes adaptive arteriogenesis and angiogenesis. (PubMed id 20395596)1 Luo Y....Min W. (Arterioscler. Thromb. Vasc. Biol. 2010)
    265. Tumor necrosis factor alpha and its soluble receptors in obese children with NAFLD. (PubMed id 20371430)1 Lebensztejn D.M....Kaczmarski M. (Adv Med Sci 2010)
    266. Levels of salivary IFN-gamma, TNF-alfa, and TNF receptor-2 as prognostic markers in (erosive) oral lichen planus. (PubMed id 21403886)1 Ghallab N.A....Shaker O.G. (Mediators Inflamm. 2010)
    267. TNF activates a NF-kappaB-regulated cellular program in human CD45RA- regulatory T cells that modulates their suppressive function. (PubMed id 20181891)1 Nagar M....Goldstein I. (J. Immunol. 2010)
    268. Elevated levels of soluble TNF receptors 1 and 2 correlate with Plasmodium falciparum parasitemia in pregnant women: potential markers for malaria-associated inflammation. (PubMed id 20980627)1 ThAcvenon A.D....Taylor D.W. (J. Immunol. 2010)
    269. [Gene polymorphism of tumor necrosis factor-alpha receptor II in 196 site and premature births in Chinese Han Population]. (PubMed id 20369486)1 Pu J. and Zeng W.Y. (Sichuan Da Xue Xue Bao Yi Xue Ban 2010)
    270. Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1 or TNFR2. (PubMed id 20045350)1 Shibata H....Tsutsumi Y. (Cytokine 2010)
    271. Impact of genomic risk factors on outcome after hematopoietic stem cell transplantation for patients with chronic myeloid leukemia. (PubMed id 20305143)1 Dickinson A.M....Gratwohl A. (Haematologica 2010)
    272. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    273. Association study of tumor necrosis factor receptor type 2 M196R and toll-like receptor 2 Arg753Gln polymorphisms with acne vulgaris in a Chinese Han ethnic group. (PubMed id 20861605)1 Tian L.M....Wang W.Z. (Dermatology (Basel) 2010)
    274. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    275. The association of tumor necrosis factor alpha receptor 2 and tumor necrosis factor alpha with insulin resistance and the influence of adipose tissue biomarkers in humans. (PubMed id 19846171)1 Hivert M.F....Meigs J.B. (Metab. Clin. Exp. 2010)
    276. Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. (PubMed id 19262425)1 Bowes J.D....Barton A. (Pharmacogenet. Genomics 2009)
    277. MEK, p38, and PI-3K mediate cross talk between EGFR and TNFR in enhancing hepatocyte growth factor production from human mesenchymal stem cells. (PubMed id 19692652)1 Wang Y....Meldrum D.R. (Am. J. Physiol., Cell Physiol. 2009)
    278. Role of TNF-I+, sTNF-R55 and sTNF-R75 in inflammation of acute exacerbations of chronic obstructive pulmonary disease. (PubMed id 19339767)1 Zeng M....Huang X. ( international review of thoracic diseases 2009)
    279. Circulating levels of TNF-alpha and its soluble receptors in the plasma of patients with epithelial ovarian cancer. (PubMed id 19825522)1 Dobrzycka B....Kinalski M. (Eur. Cytokine Netw. 2009)
    280. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    281. Plasma concentrations of TNF-alpha and its soluble receptors sTNFR1 and sTNFR2 in patients with coronary artery disease. (PubMed id 19845893)1 Safranow K....Chlubek D. (Tissue Antigens 2009)
    282. Monogenic and polygenic models detected in steroid 21-hydroxylase deficiency-related paediatric hyperandrogenism. (PubMed id 19039234)4 Ezquieta B....BellA^n J.M. (Horm. Res. 2009)
    283. Serum levels of TNF-alpha, TNF-alphaRI, TNF-alphaRII and IL-12 in treated rheumatoid arthritis patients. (PubMed id 19801788)1 Ebrahimi A.A....Ghojazadeh M. (Iran J Immunol 2009)
    284. Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men. (PubMed id 19141999)4 Giedraitis V....Glaser A. (Dement Geriatr Cogn Disord 2009)
    285. Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor. (PubMed id 19839997)1 Hope S....Andreassen O.A. (Bipolar Disord 2009)
    286. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    287. TNFR gene-modified mesenchymal stem cells attenuate inflammation and cardiac dysfunction following MI. (PubMed id 17852784)1 Bao C....Hu Z. (Scand. Cardiovasc. J. 2008)
    288. Soluble tumour necrosis factor receptors sTNFR1 and sTNFR2 are produced at sites of inflammation and are markers of arthritis activity in BehAset's disease. (PubMed id 18415772)1 Turan B....Villiger P.M. (Scand. J. Rheumatol. 2008)
    289. Comparing Type D personality and older age as correlates of tumor necrosis factor-alpha dysregulation in chronic heart failure. (PubMed id 18068948)1 Denollet J....Conraads V.M. (Brain Behav. Immun. 2008)
    290. Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (PubMed id 18593464)1 Jin P.... Paleolog E.M. (Arthritis Res. Ther. 2008)
    291. Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism. (PubMed id 18755894)1 Ban L....Faustman D.L. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    292. Oxidative stress promotes ligand-independent and enhanced ligand-dependent tumor necrosis factor receptor signaling. (PubMed id 18544535)1 Ozsoy H.Z....Mann D.L. (J. Biol. Chem. 2008)
    293. Increased serum levels of inflammatory markers in chronic institutionalized patients with schizophrenia. (PubMed id 18679053)1 Coelho F.M....Teixeira A.L. (Neuroimmunomodulation 2008)
    294. The role of IL-12 and TNF-alpha in AIDP and AMAN. (PubMed id 18717726)1 Deng H....Zhu J. (Eur. J. Neurol. 2008)
    295. Simple and highly sensitive assay system for TNFR2-mediated soluble- and transmembrane-TNF activity. (PubMed id 18417150)1 Abe Y....Tsutsumi Y. (J. Immunol. Methods 2008)
    296. Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation. (PubMed id 18671942)1 Carpentier I....Beyaert R. (Biochem. Biophys. Res. Commun. 2008)
    297. Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children. (PubMed id 18337349)1 GarcA-a M.M....Cardoni R.L. (Am. J. Trop. Med. Hyg. 2008)
    298. Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1. (PubMed id 18429822)1 Kato T. Jr.... Ono Y. (Genes Cells 2008)
    299. Cytokine levels of TGF-beta, IL-10, and sTNFalphaRII in type C chronic liver disease. (PubMed id 18080762)1 Verma V....Kar P. (Dig. Dis. Sci. 2008)
    300. Tumour necrosis factor receptor 2 (TNFRSF1B) association study in SjAPgren's syndrome. (PubMed id 17998218)1 Miceli-Richard C....Mariette X. (Ann. Rheum. Dis. 2007)
    301. Protein and gene expression of tumour necrosis factor receptors I and II and their promoter gene polymorphisms in Alzheimer's disease. (PubMed id 17267158)1 Culpan D....Wilcock G.K. (Exp. Gerontol. 2007)
    302. Combined tumour necrosis factor-alpha and tumour necrosis factor receptor genotypes could predict rheumatoid arthritis patients' response to anti-TNF-alpha therapy and explain controversies of studies based on a single polymorphism. (PubMed id 17409133)4 Chatzikyriakidou A....Drosos A.A. (Rheumatology (Oxford) 2007)
    303. Soluble vascular cell adhesion molecule-1 is independently associated with soluble tumor necrosis factor receptor 2 in Japanese type 2 diabetic patients. (PubMed id 17258924)1 Nabeya D....Seino Y. (amp 2007)
    304. Genetic disregulation of TNF alpha and TNF alpha type II receptors in colon cancer at the II and III stage of disease. (PubMed id 18088549)1 Muc-Wierzgon M....Wierzgon J. (J. Biol. Regul. Homeost. Agents 2006)
    305. Divergent relationships among soluble tumor necrosis factor-alpha receptors 1 and 2, insulin resistance, and endothelial function. (PubMed id 16732051)1 Esteve E....FernA!ndez-Real J.M. (Diabetes Care 2006)
    306. An alternatively spliced soluble TNF-alpha receptor is associated with metabolic disorders: a replication study. (PubMed id 16979382)1 FernA!ndez-Real J.M....Delgado E. (Clin. Immunol. 2006)
    307. Soluble tumor necrosis factor receptor 2 is independently associated with brachial-ankle pulse-wave velocity in nonobese Japanese type 2 diabetic patients. (PubMed id 16732050)1 Ohgushi M....Seino Y. (Diabetes Care 2006)
    308. HIV-1 gp120 up-regulation of the mu opioid receptor in TPA-differentiated HL-60 cells. (PubMed id 16846840)1 Beltran J.A....Chang S.L. (Int. Immunopharmacol. 2006)
    309. An alternative spliced variant of circulating soluble tumor necrosis factor-alpha receptor-2 is paradoxically associated with insulin action. (PubMed id 16645020)1 FernA!ndez-Real J.M....Ricart W. (Eur. J. Endocrinol. 2006)
    310. Impact of infliximab on serum leptin levels in patients with Crohn's disease. (PubMed id 15784704)1 Franchimont D....Van Gossum A. (J. Clin. Endocrinol. Metab. 2005)
    311. The (CA)n polymorphism of the TNFR2 gene is associated with peak bone density in Chinese nuclear families. (PubMed id 15886863)1 Xu H....Deng H.W. (J. Hum. Genet. 2005)
    312. A prospective study of soluble tumor necrosis factor-alpha receptor II (sTNF-RII) and risk of coronary heart disease among women with type 2 diabetes. (PubMed id 15920055)1 Shai I....Hu F.B. (Diabetes Care 2005)
    313. Up-regulation of soluble tumor necrosis factor receptor two in plasma of HIV-seropositive individuals who use opiates. (PubMed id 15000697)1 Ryan L.A....Zheng J. (AIDS Res. Hum. Retroviruses 2004)
    314. Genetic disregulation of gene coding tumor necrosis factor alpha receptors (TNFalpha Rs) in colorectal cancer cells. (PubMed id 15743036)1 Muc-Wierzgon M....Sosada K. (amp 2004)
    315. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PubMed id 14743216)1 Bouwmeester T....Superti-Furga G. (Nat. Cell Biol. 2004)
    316. NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach. (PubMed id 15485837)1 Kuai J.... Lin L.-L. (J. Biol. Chem. 2004)
    317. Tumor necrosis factor (TNF)alpha and its soluble receptor (sTNFR) p75 during acute human parvovirus B19 infection in children. (PubMed id 12880679)1 Barash J....Hahn T. (Immunol. Lett. 2003)
    318. Distinct regulation of cytosolic phospholipase A2 phosphorylation, translocation, proteolysis and activation by tumour necrosis factor-receptor subtypes. (PubMed id 12786601)1 Jupp O.J....MacEwan D.J. (Biochem. J. 2003)
    319. [A study on early activation of T lymphocytes and soluble tumor necrosis factor receptor in patients with myelodysplastic syndrome]. (PubMed id 14728878)1 Shen R....Li J. (Zhonghua Nei Ke Za Zhi 2003)
    320. TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells. (PubMed id 12882979)1 Wen L....Wei P. (J. Biol. Chem. 2003)
    321. Soluble tumor necrosis factor-alpha receptors in young obese subjects with normal and impaired glucose tolerance. (PubMed id 12610052)1 Dzienis-Straczkowska S....Kinalska I. (Diabetes Care 2003)
    322. A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. (PubMed id 14532286)1 Chan F.K....Lenardo M.J. (J. Biol. Chem. 2003)
    323. Elevated serum levels of the type I and type II receptors for tumor necrosis factor-alpha as predictive factors for ARF in patients with septic shock. (PubMed id 12500222)1 Iglesias J....Levine J.S. (Am. J. Kidney Dis. 2003)
    324. Serum levels of soluble TNF-alpha receptor-II (P75), circulating gammadelta T-cells and Adamantiades-BehAset's disease activity. (PubMed id 12918703)1 Elezoglou A.V....Kaklamanis P.G. (Adv. Exp. Med. Biol. 2003)
    325. Genetic disregulation of gene coding tumor necrosis factor alpha receptors (TNF alpha Rs) in follicular thyroid cancer--preliminary report. (PubMed id 12144133)1 Zubelewicz B....Podwinska E. (J. Biol. Regul. Homeost. Agents 2002)
    326. Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments. (PubMed id 12220546)1 Kollias G. and Kontoyiannis D. (amp 2002)
    327. TTD: Therapeutic Target Database. (PubMed id 11752352)7 Chen X....Chen Y.Z. (Nucleic Acids Res. 2002)
    328. Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 (TNFR1)- and TNFR2-mediated apoptosis in HIV infection: relation to expression of Bcl-2 and active caspase-8 and caspase-3. (PubMed id 11861282)1 de Oliveira Pinto L.M....Gougeon M.L. (Blood 2002)
    329. Genetic approaches to the investigation of rheumatoid arthritis. (PubMed id 11981324)4 Barton A. and Ollier W. (Curr Opin Rheumatol 2002)
    330. Elevation of serum eosinophil cationic protein, soluble tumor necrosis factor receptors and soluble intercellular adhesion molecule-1 levels in acute bronchial asthma. (PubMed id 12530121)1 KokuludaA9 A....Sebik F. (amp 2002)
    331. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    332. Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus. (PubMed id 11882518)1 Fernandez-Real J.M....Ricart W. (Am. J. Physiol. Endocrinol. Metab. 2002)
    333. The emerging distinct role of TNF-receptor 2 (p80) signaling in chronic inflammatory disorders. (PubMed id 12371624)1 Holtmann M.H....Neurath M.F. (Arch. Immunol. Ther. Exp. (Warsz.) 2002)
    334. An update on genetic studies of systemic lupus erythematosus. (PubMed id 12126589)4 Tsao B.P. (Curr Rheumatol Rep 2002)
    335. A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2. (PubMed id 11804591)1 Oukka M....Glimcher L.H. (Mol. Cell 2002)
    336. Increased plasma-soluble tumor necrosis factor-alpha receptor 2 level in lean nondiabetic offspring of type 2 diabetic subjects. (PubMed id 12351485)1 Straczkowski M....Kinalska I. (Diabetes Care 2002)
    337. Plasma interleukin-8 concentrations are increased in obese subjects and related to fat mass and tumor necrosis factor-alpha system. (PubMed id 12364441)1 Straczkowski M....Kinalska I. (J. Clin. Endocrinol. Metab. 2002)
    338. Relationships between fibrinolytic and inflammatory parameters in human adipose tissue: strong contribution of TNFalpha receptors to PAI-1 levels. (PubMed id 12353079)1 Bastelica D....Alessi M.C. (Thromb. Haemost. 2002)
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    409. Distinct effects of p75 in mediating actions of neurotrophins on basal forebrain oligodendrocytes. (PubMed id 16356734)9 Du Y....Dreyfus C.F. (Mol. Cell. Neurosci. 2006)
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    489. Both tumor necrosis factor receptors, TNFR60 and TNFR80, are involved in signaling endothelial tissue factor expression by juxtacrine tumor necrosis factor alpha. (PubMed id 7544644)9 Schmid E.F....Pfizenmaier K. (Blood 1995)
    490. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. (PubMed id 8521496)9 Grell M....Scheurich P. (Cell 1995)
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    494. A human tumor necrosis factor (TNF) alpha mutant that binds exclusively to the p55 TNF receptor produces toxicity in the baboon. (PubMed id 8145037)9 Van Zee K.J....StA1ber D. (J. Exp. Med. 1994)
    495. The TNF Receptors p55 and p75 Mediate Chemotaxis of PMN Induced by TNFalpha and a TNFalpha 36-62 Peptide. (PubMed id 18475579)9 Rekdal O....Osterud B. (Mediators Inflamm. 1994)
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    497. p55 and p75 tumor necrosis factor receptors in patients with chronic lymphocytic leukemia. (PubMed id 1384790)9 Waage A....Espevik T. (Blood 1992)
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    499. Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints. (PubMed id 1320571)9 Brennan F.M....Feldmann M. (Eur. J. Immunol. 1992)
    500. Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1. (PubMed id 1662415)9 Milatovich A....Francke U. (Somat. Cell Mol. Genet. 1991)
    501. Fluorescence correlation spectroscopy reveals topological segregation of the two tumor necrosis factor membrane receptors. (PubMed id 20188063)9 Gerken M....Scheurich P. (Biochim. Biophys. Acta 2010)
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    504. Blocking TNF in vitro with infliximab determines the inhibition of expansion and interferon gamma production of Vgamma9/Vdelta2 T lymphocytes from patients with active rheumatoid arthritis. A role in the susceptibility to tuberculosis? (PubMed id 19370184)9 Giardina A.R....Triolo G. (Reumatismo 2009)
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    508. Nanoscale arrangement of apoptotic ligands reveals a demand for a minimal lateral distance for efficient death receptor activation. (PubMed id 19772290)9 Ranzinger J....Scheurich P. (Nano Lett. 2009)
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    512. Tumor necrosis factor receptors (TNFRs) on T lymphocytes and soluble TNFRs in different clinical courses of sarcoidosis. (PubMed id 16889950)9 Kieszko R....Milanowski J. (Respir Med 2007)
    513. Plasma cytokine and soluble receptor signature predicts outcome of patients with classical Hodgkin's lymphoma: a study from the Groupe d'Etude des Lymphomes de l'Adulte. (PubMed id 17389336)9 Casasnovas R.O....Salles G. (J. Clin. Oncol. 2007)
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    515. Thioredoxin and thioredoxin-binding protein-2 in cancer and metabolic syndrome. (PubMed id 17697931)9 Kaimul A.M....Yodoi J. (amp 2007)
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    518. Serum neopterin, tumor necrosis factor-alpha and soluble tumor necrosis factor receptor II (p75) levels and disease activity in Egyptian female patients with systemic lupus erythematosus. (PubMed id 15642275)9 Mahmoud R.A....Ahmed H.H. (Clin. Biochem. 2005)
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    521. Altered expression and activation of the nerve growth factor receptors TrkA and p75 provide the first evidence of tumor progression to effusion in breast carcinoma. (PubMed id 14997042)9 Davidson B....Nesland J.M. (Breast Cancer Res. Treat. 2004)
    522. Expression of nerve growth factor (NGF), and its receptors trkA and p75 in ovaries of the cyclic golden hamster (Mesocricetus auratus) and the regulation of their production by luteinizing hormone. (PubMed id 15647611)9 Shi Z....Taya K. (J. Reprod. Dev. 2004)
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    524. Circulating tumour necrosis factor alpha &amp; soluble TNF receptors in patients with Guillain-Barre syndrome. (PubMed id 14609050)9 Radhakrishnan V.V....Nair M.D. (Indian J. Med. Res. 2003)
    525. Novel functional interactions between Trk kinase and p75 neurotrophin receptor in neuroblastoma cells. (PubMed id 12503079)9 Lachyankar M.B....Ross A.H. (J. Neurosci. Res. 2003)
    526. Development of androgen receptor and p75(NTR) mRNAs and peptides in the lumbar spinal cord of the gerbil. (PubMed id 12220702)9 Fraley G.S. and Ulibarri C. (Brain Res. Dev. Brain Res. 2002)
    527. GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia. (PubMed id 11745618)9 Josephson A....Spenger C. (J. Comp. Neurol. 2001)
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    530. A menstrual cycle pattern for cytokine levels exists in HIV-positive women: implication for HIV vaginal and plasma shedding. (PubMed id 11504986)9 Al-Harthi L....Landay A. (AIDS 2001)
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    537. Tumor necrosis factor-alpha mediates orthopedic implant osteolysis. (PubMed id 9916934)9 Merkel K.D....Teitelbaum S.L. (Am. J. Pathol. 1999)
    538. Relationship between plasma leptin levels and the tumor necrosis factor-alpha system in obese subjects. (PubMed id 10340812)9 Corica F....Ceruso D. (Int. J. Obes. Relat. Metab. Disord. 1999)
    539. Suppression of growth and dissemination in human pre-B leukemia cells by tumor necrosis factor-alpha in scid mice. (PubMed id 10194127)9 Yoshida N....Miyazaki S. (amp 1999)
    540. Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements. (PubMed id 9764776)9 Fahey J.L....Detels R. (AIDS 1998)
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    543. Differential expression of a tumor necrosis factor receptor-related transcript in gestational trophoblastic diseases in women. (PubMed id 9716562)9 Dumur C.I.... Patrito L.C. (Biol. Reprod. 1998)
    544. Maternal serum levels of interleukin-6 and clinical characteristics of normal delivery at term. (PubMed id 9033245)9 Arntzen K.J....Austgulen R. (Acta Obstet Gynecol Scand 1997)
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    549. In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis. (PubMed id 9394812)9 KA1sters S....Grell M. (Eur. J. Immunol. 1997)
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    551. Tumour necrosis factor alpha and its soluble receptors parallel clinical disease and autoimmune activity in systemic lupus erythematosus. (PubMed id 8948291)9 Studnicka-Benke A....Smolen J.S. (Br. J. Rheumatol. 1996)
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    553. Structural and biological features of the TNF receptor and TNF ligand superfamilies: interactive signals in the pathobiology of Hodgkin's disease. (PubMed id 8836404)9 Gruss H.J....Herrmann F. (Ann. Oncol. 1996)
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    557. Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour necrosis factor (TNF) receptor is mediated by endogenous murine TNF. (PubMed id 7578985)9 Vercammen D....Fiers W. (Cytokine 1995)
    558. Soluble tumour necrosis factor receptors p55 and p75 in the urine monitor disease activity and the efficacy of treatment of inflammatory bowel disease. (PubMed id 7557578)9 Hadziselimovic F....Gallati H. (Gut 1995)
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    604. BDNF in RA: downregulated in plasma following anti-TNF treatment but no correlation with inflammatory parameters. (PubMed id 18484150)9 Grimsholm O....Forsgren S. (Clin. Rheumatol. 2008)
    605. TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. (PubMed id 18313334)9 Gardam S....Brink R. (Immunity 2008)
    606. Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2. (PubMed id 18794145)9 Zheng M....Sun Y. (Cancer Res. 2008)
    607. Non-response to infliximab may be due to innate neutralizing anti-tumour necrosis factor-alpha antibodies. (PubMed id 18826498)9 Ebert E.C....Rezac C. (Clin. Exp. Immunol. 2008)
    608. TL1A both promotes and protects from renal inflammation and injury. (PubMed id 18287561)9 Al-Lamki R.S....Bradley J.R. (J. Am. Soc. Nephrol. 2008)
    609. Human idiopathic epiretinal membranes express NGF and NGF receptors. (PubMed id 18398367)9 Minchiotti S....Bonini S. (Retina (Philadelphia, Pa.) 2008)
    610. Neurotrophin receptor expression in human primary retinoblastomas and retinoblastoma cell lines. (PubMed id 17973327)9 Stephan H....Eggert A. (amp 2008)
    611. Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection. (PubMed id 18426996)9 Schnabel R....Benjamin E.J. (Hypertension 2008)
    612. TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. (PubMed id 18925972)9 McCoy M.K. and Tansey M.G. (J Neuroinflammation 2008)
    613. Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese. (PubMed id 18753313)9 Qi Q....Lin X. (Eur. J. Endocrinol. 2008)
    614. Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent. (PubMed id 17295438)9 Bondeson J....Caterson B. (J. Rheumatol. 2007)
    615. A dual role for the API2 moiety in API2-MALT1-dependent NF-kappaB activation: heterotypic oligomerization and TRAF2 recruitment. (PubMed id 17334391)9 Lucas P.C....McAllister-Lucas L.M. (Oncogene 2007)
    616. Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children. (PubMed id 17997848)9 Armah H.B....Stiles J.K. (Malar. J. 2007)
    617. Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1. (PubMed id 17872973)9 Canault M....Nalbone G. (Am. J. Pathol. 2007)
    618. Tumor necrosis factor blockade in the management of children with orphan diseases. (PubMed id 17219021)9 Brik R....Berkovitz D. (Clin. Rheumatol. 2007)
    619. Correlates for disease progression and prognosis during concurrent HIV/TB infection. (PubMed id 17446108)9 Djoba Siawaya J.F....Walzl G. (Int. J. Infect. Dis. 2007)
    620. [Expression peculiarities of EGR1, neurotrophins and their receptor genes in human lung cancer and in normal lung tissue]. (PubMed id 17600921)9 Dergunoa L.V....Limborskaia S.A. (Mol. Gen. Mikrobiol. Virusol. 2007)
    621. Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study. (PubMed id 17389308)9 Jefferson A.L....DeCarli C. (Neurology 2007)
    622. Construction and purification of the murine p75-murine IgG1 fusion protein. (PubMed id 17502870)9 Kim H.Y....Kohno T. (J. Investig. Dermatol. Symp. Proc. 2007)
    623. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. (PubMed id 17709633)9 Pou K.M....Fox C.S. (Circulation 2007)
    624. Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1. (PubMed id 17724081)9 Fujino G.... Ichijo H. (Mol. Cell. Biol. 2007)
    625. TrkC: a new predictive marker in breast cancer? (PubMed id 17882651)9 Blasco-GutiAcrrez M.J....GarcA-a-AtarAcs N. (Cancer Invest. 2007)
    626. The Trk tyrosine kinase inhibitor K252a regulates growth of lung adenocarcinomas. (PubMed id 16862449)9 Perez-Pinera P....Vega J.A. (Mol. Cell. Biochem. 2007)
    627. Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling. (PubMed id 17314283)9 Henn I.H....Winklhofer K.F. (J. Neurosci. 2007)
    628. Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells. (PubMed id 17413467)9 Abe Y....Masuda K. (Spine 2007)
    629. TRAF1 and its biological functions. (PubMed id 17633014)9 Lee S.Y. and Choi Y. (Adv. Exp. Med. Biol. 2007)
    630. Predominant activation of MAP kinases and pro-destructive/pro-inflammatory features by TNF alpha in early-passage synovial fibroblasts via TNF receptor-1: failure of p38 inhibition to suppress matrix metalloproteinase-1 in rheumatoid arthritis. (PubMed id 17223661)9 Kunisch E....Kinne R.W. (Ann. Rheum. Dis. 2007)
    631. Systemic inflammatory mediators and bone homeostasis in intestinal failure. (PubMed id 17308255)9 Compher C....Hise M. (JPEN J Parenter Enteral Nutr 2007)
    632. Retinoic acid enhances Erk phosphorylation in the chick retina. (PubMed id 17881122)9 Kampmann E. and Mey J. (Neurosci. Lett. 2007)
    633. [Autoimmune aspects of treatment with TNF-alpha inhibitors]. (PubMed id 17786135)9 Kolarz B....Majdan M. (Postepy Hig Med Dosw (Online) 2007)
    634. Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system. (PubMed id 17172268)9 Berndt C....Holmgren A. (Am. J. Physiol. Heart Circ. Physiol. 2007)
    635. Different TNFalpha expression elicited by glucose in monocytes from type 2 diabetes mellitus patients. (PubMed id 17244513)9 ChacA^n M.R....Garcia-EspaA+a A. (Atherosclerosis 2007)
    636. Novel action of n-3 polyunsaturated fatty acids: inhibition of arachidonic acid-induced increase in tumor necrosis factor receptor expression on neutrophils and a role for proteases. (PubMed id 17328054)9 Moghaddami N....Ferrante A. (Arthritis Rheum. 2007)
    637. Association of classical and related inflammatory markers with high-sensitivity C-reactive protein in healthy individuals: results from the Stanislas cohort. (PubMed id 17727316)9 Berrahmoune H....Visvikis-Siest S. (Clin. Chem. Lab. Med. 2007)
    638. Characterization of porcine tumor necrosis factor receptor 2: implications for xenotransplantation. (PubMed id 17889214)9 Costa C....Fodor W.L. (Transplant. Proc. 2007)
    639. Physiological roles and mechanisms of signaling by TRAF2 and TRAF5. (PubMed id 17633015)9 Au P.Y. and Yeh W.C. (Adv. Exp. Med. Biol. 2007)
    640. The role of TNF-alpha and its receptors in the production of NGF and GDNF by astrocytes. (PubMed id 16956589)9 Kuno R....Suzumura A. (Brain Res. 2006)
    641. Activation of toll-like receptor-9 induces matrix metalloproteinase-9 expression through Akt and tumor necrosis factor-alpha signaling. (PubMed id 16870179)9 Lim E.J....Baek S.H. (FEBS Lett. 2006)
    642. Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals. (PubMed id 16636664)9 Wu Y....Yin Z. (Oncogene 2006)
    643. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. (PubMed id 16219905)9 Aggarwal S....Aggarwal B.B. (Mol. Pharmacol. 2006)
    644. Etanercept decreases tumor necrosis factor-alpha activity in chronic wound fluid. (PubMed id 16939569)9 Cowin A.J....Belford D.A. (Wound Repair Regen 2006)
    645. Expression of TWEAK and its receptor Fn14 in human subcutaneous adipose tissue. Relationship with other inflammatory cytokines in obesity. (PubMed id 16503147)9 ChacA^n M.R....Vendrell J. (Cytokine 2006)
    646. Expression of TNF-alpha and related signaling molecules in the peripheral blood mononuclear cells of rheumatoid arthritis patients. (PubMed id 16951485)9 Raghav S.K....Das H.R. (Mediators Inflamm. 2006)
    647. Increased levels of soluble TNF-alpha receptors and cellular adhesion molecules in patients undergoing bioincompatible hemodialysis. (PubMed id 16988495)9 Rysz J....Baj Z. (Am. J. Nephrol. 2006)
    648. Expression of thioredoxin and thioredoxin-binding protein-2 in the liver of patients with chronic hepatitis C as a predictor of response to interferon therapy. (PubMed id 16685406)9 Hamano K....Kasuga M. (Int. J. Mol. Med. 2006)
    649. Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor alpha. (PubMed id 16947419)9 Edwards C.K....Dinarello C.A. (Arthritis Rheum. 2006)
    650. Thioredoxin in cancer--role of histone deacetylase inhibitors. (PubMed id 17095247)9 Marks P.A. (Semin. Cancer Biol. 2006)
    651. TNFR-Fc fusion protein expressed by in vivo electroporation improves survival rates and myocardial injury in coxsackievirus induced murine myocarditis. (PubMed id 16631119)9 Kim J.M....Jeon E.S. (Biochem. Biophys. Res. Commun. 2006)
    652. Use of etanercept in human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) patients. (PubMed id 16796629)9 Ting P.T. and Koo J.Y. (Int. J. Dermatol. 2006)
    653. Extracellular thioredoxin and thioredoxin-binding protein 2 in control of cancer. (PubMed id 17095246)9 Nakamura H....Yodoi J. (Semin. Cancer Biol. 2006)
    654. [Changes in gene expression in the course of proliferative processes in the parathyroid gland]. (PubMed id 16888677)9 Szende B....Perner F. (Magy Onkol 2006)
    655. Allogeneic activation is attenuated in a model of mouse lung perfused with magnesium-deficient blood. (PubMed id 17138054)9 Sabbagh F....German-Fattal M. (Transpl. Immunol. 2006)
    656. Thioredoxin-binding protein-2-like inducible membrane protein is a novel vitamin D3 and peroxisome proliferator-activated receptor (PPAR)gamma ligand target protein that regulates PPARgamma signaling. (PubMed id 16269462)9 Oka S....Yodoi J. (Endocrinology 2006)
    657. TNF and TNF receptor expression and insulin sensitivity in human omental and subcutaneous adipose tissue--influence of BMI and adipose distribution. (PubMed id 16784178)9 Good M....Prins J.B. (amp 2006)
    658. Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia. (PubMed id 16414245)9 Bowden N.A....Tooney P.A. (Schizophr. Res. 2006)
    659. Trophic factors in cerebrospinal fluid and spinal cord of patients with tropical spastic paraparesis, HIV, and Creutzfeldt-Jakob disease. (PubMed id 16545011)9 Albrecht D....Valenzuela M.A. (AIDS Res. Hum. Retroviruses 2006)
    660. Relationship between plasma concentrations of cytokines, ratio of CD4 and CD8, lymphocyte proliferative responses, and depressive and anxiety state in bulimia nervosa. (PubMed id 16380316)9 Nagata T....Kiriike N. (J Psychosom Res 2006)
    661. Successful antidepressant therapy restores the disturbed interplay between TNF-alpha system and HPA axis. (PubMed id 16989778)9 Himmerich H....Ising M. (Biol. Psychiatry 2006)
    662. Interferon induces NF-kappa B-inducing kinase/tumor necrosis factor receptor-associated factor-dependent NF-kappa B activation to promote cell survival. (PubMed id 16009713)9 Yang C.H....Pfeffer L.M. (J. Biol. Chem. 2005)
    663. Pneumococcal meningitis and etanercept--chance or association? (PubMed id 16038750)9 Killingley B....Pasvol G. (J. Infect. 2005)
    664. Apoptotic markers on lymphocytes and monocytes are unchanged during single hemodialysis sessions using either regenerated cellulose or polysulfone membranes. (PubMed id 16175944)9 Wu C.C....Lin Y.F. (Clin. Nephrol. 2005)
    665. TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. (PubMed id 15708970)9 Hauer J....Engelmann H. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    666. Tumor necrosis factor alpha promotes invasiveness of cholangiocarcinoma cells via its receptor, TNFR2. (PubMed id 15723721)9 Tanimura Y....Hamaguchi M. (Cancer Lett. 2005)
    667. A shift to a peripheral Th2-type cytokine pattern during the carcinogenesis of cervical cancer becomes manifest in CIN III lesions. (PubMed id 16189158)9 Bais A.G....Helmerhorst T.J. (J. Clin. Pathol. 2005)
    668. Relationship between exercise intolerance and levels of neurohormonal factors and proinflammatory cytokines in patients with stable chronic heart failure. (PubMed id 16394601)9 Itoh K....Miyake F. (Int Heart J 2005)
    669. Evidence of a mechanism by which etanercept increased TNF-alpha in multiple myeloma: new insights into the biology of TNF-alpha giving new treatment opportunities--the role of bupropion. (PubMed id 15964626)9 Kast R.E. (Leuk. Res. 2005)
    670. Exercise training in chronic heart failure: effects on pro-inflammatory markers. (PubMed id 15701465)9 Niebauer J....Coats A.J. (Eur. J. Heart Fail. 2005)
    671. Cytokines, cytokine antagonists and soluble adhesion molecules in patients with ocular BehAset's disease treated with human recombinant interferon-alpha2a. Results of an open study and review of the literature. (PubMed id 16273760)9 KAPtter I....StA1biger N. (Clin. Exp. Rheumatol. 2005)
    672. Protection of human cerebral neurons from neurodegenerative insults by gene delivery of soluble tumor necrosis factor p75 receptor. (PubMed id 15827736)9 Williams M.A....Drachman D.B. (Exp Brain Res 2005)
    673. Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptors. (PubMed id 15852477)9 Balosso S....Vezzani A. (Ann. Neurol. 2005)
    674. Amino-terminal TACE prodomain attenuates TNFR2 cleavage independently of the cysteine switch. (PubMed id 15749738)9 Buckley C.A....Levine S.J. (Am. J. Physiol. Lung Cell Mol. Physiol. 2005)
    675. Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival. (PubMed id 16049186)9 Kuwako K....Yoshikawa K. (J. Neurosci. 2005)
    676. Anti-TNF-alpha therapy in ankylosing spondylitis. (PubMed id 15212600)9 Wendling D. and Toussirot E. (Expert Opin Pharmacother 2004)
    677. Etanercept for the treatment of psoriasis and psoriatic arthritis. (PubMed id 15379775)9 Gottlieb A.B. (Dermatol Ther 2004)
    678. Upregulation and colocalization of p75 and Nav1.8 in Purkinje neurons in experimental autoimmune encephalomyelitis. (PubMed id 15464262)9 Damarjian T.G....Waxman S.G. (Neurosci. Lett. 2004)
    679. Marek's disease is a natural model for lymphomas overexpressing Hodgkin's disease antigen (CD30). (PubMed id 15356338)9 Burgess S.C....Davison T.F. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    680. Circulating cytokines in primary SjAPgren's syndrome determined by a multiplex cytokine array system. (PubMed id 15182255)9 Szodoray P....Jonsson R. (Scand. J. Immunol. 2004)
    681. A pilot study of the safety and tolerability of etanercept in patients with alcoholic hepatitis. (PubMed id 15046213)9 Menon K.V....Shah V. (Am. J. Gastroenterol. 2004)
    682. Nerve growth factor-induced protein kinase C stimulation contributes to TrkA-dependent inhibition of p75 neurotrophin receptor sphingolipid signaling. (PubMed id 15264216)9 Plo I....Laurent G. (J. Neurosci. Res. 2004)
    683. Correlation of serum soluble TNF-alpha receptors I and II levels with disease activity in patients with ulcerative colitis. (PubMed id 15307873)9 Hanai H....Saniabadi A. (Am. J. Gastroenterol. 2004)
    684. Lipodystrophy in patients with HIV-1 infection: effect of stopping protease inhibitors on TNF-alpha and TNF-receptor levels, and on metabolic parameters. (PubMed id 15651746)9 Maher B....Pirmohamed M. (Antivir. Ther. (Lond.) 2004)
    685. Lowered tumor necrosis factor receptors, but not increased insulin sensitivity, with infliximab. (PubMed id 15090644)9 Di Rocco P....Mingrone G. (Obes. Res. 2004)
    686. Serum tumour necrosis factor-alpha and soluble tumour necrosis factor receptors levels in patients with Guillain-Barre syndrome. (PubMed id 14653854)9 Radhakrishnan V.V....Nair M.D. (Acta Neurol. Scand. 2004)
    687. Overexpression of tumor necrosis factor (TNF)alpha and TNFalpha receptor I in human viral myocarditis: clinicopathologic correlations. (PubMed id 15218506)9 Calabrese F....Thiene G. (Mod. Pathol. 2004)
    688. Inflammatory cytokines in acute renal failure. (PubMed id 15461705)9 Ramesh G. and Reeves W.B. (Kidney Int. Suppl. 2004)
    689. A low serum level of soluble tumor necrosis factor receptor p55 predicts response to thalidomide in advanced multiple myeloma. (PubMed id 15136218)9 Brenne A.T....Waage A. (Haematologica 2004)
    690. P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasis. (PubMed id 14745712)9 Magez S....De Baetselier P. (J. Infect. Dis. 2004)
    691. Etanercept: in ankylosing spondylitis. (PubMed id 15161337)9 McCormack P.L. and Wellington K. (BioDrugs 2004)
    692. Lymphotoxin and LIGHT signaling pathways and target genes. (PubMed id 15546385)9 Schneider K....Ware C.F. (Immunol. Rev. 2004)
    693. Correlations among neural cell adhesion molecule, nerve growth factor, and its receptors, TrkA, TrkB, TrkC, and p75, in perineural invasion by basal cell and cutaneous squamous cell carcinomas. (PubMed id 15209791)9 Chen-Tsai C.P....Wagner R.F. (Dermatol Surg 2004)
    694. Cardiomyocyte death in patients with end-stage heart failure before and after support with a left ventricular assist device: low incidence of apoptosis despite ubiquitous mediators. (PubMed id 12957613)9 de Jonge Weger R.A. (J. Heart Lung Transplant. 2003)
    695. Unique effect of arachidonic acid on human neutrophil TNF receptor expression: up-regulation involving protein kinase C, extracellular signal-regulated kinase, and phospholipase A2. (PubMed id 12928414)9 Moghaddami N....Ferrante A. (J. Immunol. 2003)
    696. Innate immune system is implicated in recurrent aphthous ulcer pathogenesis. (PubMed id 12901729)9 Lewkowicz N....TchA^rzewski H. (amp 2003)
    697. Synergy between all-trans retinoic acid and tumor necrosis factor pathways in acute leukemia cells. (PubMed id 12586626)9 Witcher M....Miller W.H. (Blood 2003)
    698. Meningeal cells enhance limited CNS remyelination by transplanted olfactory ensheathing cells. (PubMed id 12566281)9 Lakatos A....Franklin R.J. (Brain 2003)
    699. Tumor necrosis factor-induced nuclear factor kappaB activation is impaired in focal adhesion kinase-deficient fibroblasts. (PubMed id 12748169)9 Funakoshi-Tago M....Kasahara T. (J. Biol. Chem. 2003)
    700. Comparative analysis of genes regulated by PML/RAR alpha and PLZF/RAR alpha in response to retinoic acid using oligonucleotide arrays. (PubMed id 12893766)9 Park D.J....Koeffler H.P. (Blood 2003)
    701. Vgamma9/Vdelta2 T lymphocytes in Italian patients with BehAset's disease: evidence for expansion, and tumour necrosis factor receptor II and interleukin-12 receptor beta1 expression in active disease. (PubMed id 12932289)9 Triolo G....Licata G. (amp 2003)
    702. Influence of leptin and the TNF system on insulin resistance in pregnancy and their effect on anthropometric parameters of newborns. (PubMed id 12752073)9 Melczer Z....Cseh K. (Acta Obstet Gynecol Scand 2003)
    703. Modulation by caspases of tumor necrosis factor-stimulated c-Jun N-terminal kinase activation but not nuclear factor-kappaB signaling. (PubMed id 12473383)9 Littlejohn A.F....MacEwan D.J. (Biochem. Pharmacol. 2003)
    704. In situ localization of TNFalpha/beta, TACE and TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue. (PubMed id 12849708)9 Ermert M....Ermert L. (Cytokine 2003)
    705. Genetic determinants of susceptibility to osteoporosis. (PubMed id 12699293)9 Albagha O.M. and Ralston S.H. (Endocrinol. Metab. Clin. North Am. 2003)
    706. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and TNF-alpha promote the NF-kappaB-dependent maturation of normal and leukemic myeloid cells. (PubMed id 12885939)9 Secchiero P....Zauli G. (J. Leukoc. Biol. 2003)
    707. Cytokine and cytokine receptor serum levels in adult bone sarcoma patients: correlations with local tumor extent and prognosis. (PubMed id 14598359)9 Rutkowski P....Steffen J. (J Surg Oncol 2003)
    708. The role of nuclear factor kappaB in tumor necrosis factor-regulated transcription of the human mu-opioid receptor gene. (PubMed id 14500744)9 Kraus J....HAPllt V. (Mol. Pharmacol. 2003)
    709. ErbB-2/HER-2 protein expression, serum tumour necrosis factor-alpha (TFM-alpha) and soluble tumour necrosis factor receptor-2 (TNFR-2) concentrations in human carcinoma of the uterine cervix. (PubMed id 12701963)9 Melczer Z....Cseh K. (Eur. J. Gynaecol. Oncol. 2003)
    710. Apoptotic response to 5-fluorouracil treatment is mediated by reduced polyamines, non-autocrine Fas ligand and induced tumor necrosis factor receptor 2. (PubMed id 14614330)9 Zhang W....Hamilton S.R. (amp 2003)
    711. Pilot study of recombinant human soluble tumor necrosis factor (TNF) receptor (p75) fusion protein (TNFR:Fc; Enbrel) in patients with refractory multiple myeloma: increase in plasma TNF alpha levels during treatment. (PubMed id 12620287)9 Tsimberidou A.M....Giles F.J. (Leuk. Res. 2003)
    712. Activation of mitogen-activated protein kinase and NF-kappaB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein. (PubMed id 12915550)9 Brinkmann M.M....Schulz T.F. (J. Virol. 2003)
    713. Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis. (PubMed id 12441346)9 Vanden Berghe T....Vandenabeele P. (J. Biol. Chem. 2003)
    714. Preferential induction of prodestructive matrix metalloproteinase-1 and proinflammatory interleukin 6 and prostaglandin E2 in rheumatoid arthritis synovial fibroblasts via tumor necrosis factor receptor-55. (PubMed id 12913922)9 Alsalameh S....Kinne R.W. (J. Rheumatol. 2003)
    715. Effect of acute hyperglycaemia on selected plasma and urinary cytokine antagonists in Type 1 diabetes mellitus. (PubMed id 12679866)9 PelikA!novA! T....Jirsa M. (Diabetologia 2003)
    716. NGF rescues human B lymphocytes from anti-IgM induced apoptosis by activation of PKCzeta. (PubMed id 11754354)9 Kronfeld I....Brodie C. (Eur. J. Immunol. 2002)
    717. Neurotropins and their receptors are expressed in the human fetal ovary. (PubMed id 11836338)9 Anderson R.A....Spears N. (J. Clin. Endocrinol. Metab. 2002)
    718. Psoriatic arthritis: the role of TNF inhibition and the effect of its inhibition with etanercept. (PubMed id 12463460)9 Mease P. (Clin. Exp. Rheumatol. 2002)
    719. Chloroquine decreases cell-surface expression of tumour necrosis factor receptors in human histiocytic U-937 cells. (PubMed id 11849318)9 Jeong J.Y....Jue D.M. (Immunology 2002)
    720. Serum cholesterol levels in neutropenic patients with fever. (PubMed id 12005222)9 Fraunberger P....Seidel D. (Clin. Chem. Lab. Med. 2002)
    721. Oxidative stress modulates tyrosine kinase receptor A and p75 receptor (low-affinity nerve growth factor receptor) expression in SHSY5Y neuroblastoma cells. (PubMed id 12028822)9 Olivieri G....Savaskan E. (amp 2002)
    722. Pharmacogenomics of response to anti-tumor necrosis factor therapy in patients with Crohn's disease. (PubMed id 12421092)9 Shetty A. and Forbes A. (Am J Pharmacogenomics 2002)
    723. Testosterone and diurnal rhythmicity of leptin, TNF-alpha and TNF-II receptor in insulin-resistant myotonic dystrophy patients. (PubMed id 12355336)9 Johansson A....Olsson T. (Int. J. Obes. Relat. Metab. Disord. 2002)
    724. Does NGF binding to p75 and trkA receptors activate independent signalling pathways to sensitize nociceptors? (PubMed id 12381805)9 Mendell L.M. (J. Physiol. (Lond.) 2002)
    725. Signaling molecules of the NF-kappa B pathway shuttle constitutively between cytoplasm and nucleus. (PubMed id 11801607)9 Birbach A....Schmid J.A. (J. Biol. Chem. 2002)
    726. Resection of pancreatic cancer normalizes the preoperative increase of tumor necrosis factor alpha gene expression. (PubMed id 12378118)9 Ariapart P....Lundkvist I. (Pancreatology 2002)
    727. Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha. (PubMed id 11986408)9 Gorman J.D....Davis J.C. (N. Engl. J. Med. 2002)
    728. Emerging role of anti-tumor necrosis factor therapy in rheumatic diseases. (PubMed id 12110156)9 Kalden J.R. (Arthritis Res. 2002)
    729. The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin. (PubMed id 12189205)9 Butler L.M....Richon V.M. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    730. [cDNA array approach to cytokine expression profile of aseptic loosened hip arthroplasty]. (PubMed id 12376864)9 Gentzsch C....Delling G. (Pathologe 2002)
    731. TNF-alpha receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurones. (PubMed id 11750919)9 Pollock J....Scott R.H. (Neuropharmacology 2002)
    732. Variations in immune response genes and their associations with multifactorial immune disorders. (PubMed id 12493014)9 Tsuchiya N....Tokunaga K. (Immunol. Rev. 2002)
    733. Role of low-affinity p75 receptor in nerve growth factor-inducible growth arrest of PC12 cells. (PubMed id 12210831)9 Ito H....Furukawa S. (J. Neurosci. Res. 2002)
    734. Effects of dexamethasone on cytokine plasma levels and white blood cell counts in depressed patients. (PubMed id 11070335)9 Schuld A....PollmAocher T. (Psychoneuroendocrinology 2001)
    735. Nerve growth factor signaling of p75 induces differentiation and ceramide-mediated apoptosis in Schwann cells cultured from degenerating nerves. (PubMed id 11746763)9 Hirata H....Uchida A. (Glia 2001)
    736. Quantitative flow cytometry shows activation of the TNF-alpha system but not of the IL-2 system at the single cell level in renal replacement therapy. (PubMed id 11427636)9 van Riemsdijk-Van Overbeeke I.C....Weimar W. (Nephrol. Dial. Transplant. 2001)
    737. Does diabetes target ganglion neurones? Progressive sensory neurone involvement in long-term experimental diabetes. (PubMed id 11673332)9 Zochodne D.W....Johnston J. (Brain 2001)
    738. Nerve growth factor exerts differential effects on the growth of human pancreatic cancer cells. (PubMed id 11205897)9 Zhu Z.W....BA1chler M.W. (Clin. Cancer Res. 2001)
    739. [Measurement of the serum concentrations of tumor necrosis factor alpha and its soluble receptors in normal and pre-eclamptic pregnant patients]. (PubMed id 11552506)9 NA_A+ez-GonzA!lez J.R....Romero-AdriA!n T. (Invest Clin 2001)
    740. Leukocyte, platelet and endothelial activation in patients with acute renal failure treated by intermittent hemodialysis. (PubMed id 11509797)9 de SA! H.M....Marques A.A. (Am. J. Nephrol. 2001)
    741. Molecular interactions between neurotrophin receptors. (PubMed id 11545260)9 Dechant G. (Cell Tissue Res. 2001)
    742. Genetic analysis as a valuable key to diagnosis and treatment of periodic Fever. (PubMed id 11700162)9 Simon A....Drenth J.P. (Arch. Intern. Med. 2001)
    743. Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine. (PubMed id 11726207)9 Zhang C....Kitajima S. (Biochem. Biophys. Res. Commun. 2001)
    744. Tumor necrosis factor inhibitors: new options for treating rheumatoid arthritis. (PubMed id 11574988)9 Moreland L.W. (Isr. Med. Assoc. J. 2001)
    745. Proinflammatory cytokine inhibitors, TNF-alpha and oxidative burst of polymorphonuclear leukocytes in the pathogenesis of sepsis in newborns. (PubMed id 11348020)9 Sikora J.P....Chrul S. (Arch. Immunol. Ther. Exp. (Warsz.) 2001)
    746. Expression of proinflammatory cytokines and their inhibitors during the course of spontaneous bacterial peritonitis. (PubMed id 11508666)9 RodrA-guez-Ramos C....GirA^n-GonzA!lez J.A. (Dig. Dis. Sci. 2001)
    747. Endogenous nitric oxide and soluble tumor necrosis factor receptor levels are enhanced in infants with congenital heart disease. (PubMed id 11700425)9 Buchhorn R....Loppnow H. (Crit. Care Med. 2001)
    748. Activation of peripheral blood neutrophils from patients with active advanced tuberculosis. (PubMed id 11414749)9 AlemA!n M....Sasiain M.C. (Clin. Immunol. 2001)
    749. Effects of sleep on endotoxin-induced host responses in healthy men. (PubMed id 11485110)9 Haack M....PollmAocher T. (Psychosom Med 2001)
    750. Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. (PubMed id 11732005)9 Crespo J....Pons-Romero F. (Hepatology 2001)
    751. Expression of different NF-kappaB pathway genes in dendritic cells (DCs) or macrophages assessed by gene expression profiling. (PubMed id 11573245)9 Baltathakis I....Boldt D.H. (J. Cell. Biochem. 2001)
    752. TNF blockade in the treatment of rheumatoid arthritis: infliximab versus etanercept. (PubMed id 11336570)9 Mikuls T.R. and Moreland L.W. (Expert Opin Pharmacother 2001)
    753. Limited efficacy of thalidomide in the treatment of febrile attacks of the hyper-IgD and periodic fever syndrome: a randomized, double-blind, placebo-controlled trial. (PubMed id 11504824)9 Drenth J.P....van der Meer J.W. (J. Pharmacol. Exp. Ther. 2001)
    754. Cytokines in rheumatoid arthritis: trials and tribulations. (PubMed id 10904249)9 Carteron N.L. (Mol Med Today 2000)
    755. Non-linear cortico-cortical interactions modulated by cholinergic afferences from the rat basal forebrain. (PubMed id 11164650)9 Villa A.E....Vantini G. (BioSystems 2000)
    756. Modulation of endometrial steroid receptors and growth regulatory genes by tamoxifen. (PubMed id 10775732)9 Elkas J....Gray K. (Obstet Gynecol 2000)
    757. [TNF alpha and heart failure]. (PubMed id 11253333)9 Pergola V....Iacono A. (Minerva Cardioangiol 2000)
    758. Systemic lupus erythematosus candidate genes in the Italian population: evidence for a significant association with interleukin-10. (PubMed id 10643707)9 D'Alfonso S....Momigliano-Richardi P. (Arthritis Rheum. 2000)
    759. Toremifene increases the expression of intercellular adhesion molecule-1 (ICAM-1) on MCF-7 breast cancer cells and Jurkat cells. (PubMed id 10632979)9 Komi J. and Lassila O. (Scand. J. Immunol. 2000)
    760. An analysis of 14 molecular markers for monitoring osteoarthritis: segregation of the markers into clusters and distinguishing osteoarthritis at baseline. (PubMed id 10806045)9 Otterness I.G....Weiner E. (Osteoarthr. Cartil. 2000)
    761. Highly active antiretroviral therapy (HAART) and circulating markers of immune activation: specific effect of HAART on neopterin. (PubMed id 10973464)9 Amirayan-Chevillard N....Capo C. (Clin. Diagn. Lab. Immunol. 2000)
    762. Gene expression of TNF-receptors in peripheral blood mononuclear cells of patients with alcoholic cirrhosis. (PubMed id 10673067)9 Hanck C....Rossol S. (J. Hepatol. 2000)
    763. Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group. (PubMed id 10717011)9 Lovell D.J....Finck B.K. (N. Engl. J. Med. 2000)
    764. Lupus susceptibility genes on human chromosome 1. (PubMed id 11016422)9 Tsao B.P. (Int. Rev. Immunol. 2000)
    765. Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2. (PubMed id 10617615)9 Leonardi A....Siebenlist U. (J. Biol. Chem. 2000)
    766. Neurotrophin regulation of sodium and calcium channels in human neuroblastoma cells. (PubMed id 10683584)9 Urbano F.J. and BuA+o W. (Neuroscience 2000)
    767. TNF-alpha-induced secretion of C-C chemokines modulates C-C chemokine receptor 5 expression on peripheral blood lymphocytes. (PubMed id 10843668)9 Hornung F....Lenardo M.J. (J. Immunol. 2000)
    768. TNF-alpha and its receptors mediate graft rejection and loss after liver transplantation. (PubMed id 11156356)9 Grenz A....Viebahn R. (Clin. Chem. Lab. Med. 2000)
    769. Expression of genes coding for the tumor necrosis factor and lymphotoxin ligand-receptor system in non-Hodgkin's lymphomas. (PubMed id 11092613)9 Warzocha K....Salles G. (Cancer Immunol. Immunother. 2000)
    770. Effect of coadministration of clozapine and fluvoxamine versus clozapine monotherapy on blood cell counts, plasma levels of cytokines and body weight. (PubMed id 10805611)9 Hinze-Selch D....PollmAocher T. (Psychopharmacology (Berl.) 2000)
    771. Tumor necrosis factor-alpha-induced lung cell expression of antiapoptotic genes TRAF1 and cIAP2. (PubMed id 10657935)9 Pryhuber G.S....O'Reilly M.A. (Am. J. Respir. Cell Mol. Biol. 2000)
    772. Activation of p55 tumor necrosis factor-alpha receptor-1 coupled to tumor necrosis factor receptor-associated factor 2 stimulates intercellular adhesion molecule-1 expression by modulating a thapsigargin-sensitive pathway in human tracheal smooth muscle cells. (PubMed id 10860946)9 Amrani Y....Panettieri R.A. (Mol. Pharmacol. 2000)
    773. Ablation of tumor necrosis factor receptor type I (p55) alters oxygen-induced lung injury. (PubMed id 10781441)9 Pryhuber G.S....Nahm M.H. (Am. J. Physiol. Lung Cell Mol. Physiol. 2000)
    774. High cytosolic pool of p75 TNF receptors and delayed surface downmodulation by mononuclear cells from non-hodgkin's lymphoma patients. (PubMed id 10880265)9 Rathore V.B....Nadkarni J.J. (Cytokine 2000)
    775. Soluble cytokine receptors: novel immunotherapeutic agents. (PubMed id 11060691)9 Fernandez-Botran R. (Expert Opin Investig Drugs 2000)
    776. [Analysis of susceptibility genes to rheumatic diseases]. (PubMed id 10077998)9 Tsuchiya N. and Tokunaga K. (Nippon Rinsho 1999)
    777. A prospective randomized study of the systemic immune response after laparoscopic and conventional Nissen fundoplication. (PubMed id 10418585)9 Sietses C....Cuesta M.A. (Surgery 1999)
    778. Occurrence of cytokine receptors on different lymphoid leukaemic cells. (PubMed id 10414448)9 Koubek K....Filipec M. (Eur. J. Haematol. 1999)
    779. Progressive and selective changes in neurotrophic factor expression and substance p axonal transport induced by perinatal diabetes: protective action of antioxidant treatment. (PubMed id 10440901)9 Germani E....Gorio A. (J. Neurosci. Res. 1999)
    780. LPS mediated production of IL-1, PGE2 and PGF2alpha from term decidua involves tumour necrosis factor and tumour necrosis factor receptor p55. (PubMed id 10674980)9 Arntzen K.J....Austgulen R. (J. Reprod. Immunol. 1999)
    781. Etanercept and methotrexate combination therapy. (PubMed id 10589361)9 Bankhurst A.D. (Clin. Exp. Rheumatol. 1999)
    782. A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. (PubMed id 9920948)9 Weinblatt M.E....Burge D.J. (N. Engl. J. Med. 1999)
    783. Cytokine gene expression in peripheral blood mononuclear cells reflects a systemic immune response in alcoholic chronic pancreatitis. (PubMed id 10732290)9 Hanck C....Singer M.V. (Int. J. Pancreatol. 1999)
    784. Tumor necrosis factor receptor and Fas signaling mechanisms. (PubMed id 10358762)9 Wallach D....Boldin M.P. (Annu. Rev. Immunol. 1999)
    785. Binding of tumour necrosis factor-alpha (TNF-alpha) to TNF-RI induces caspase(s)-dependent apoptosis in human cholangiocarcinoma cell lines. (PubMed id 10209503)9 Utaisincharoen P....Sirisinha S. (Clin. Exp. Immunol. 1999)
    786. Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial. (PubMed id 10075615)9 Moreland L.W....Weinblatt M.E. (Ann. Intern. Med. 1999)
    787. Role of the 75-kDa TNF receptor in TNF-induced activation of neutrophil respiratory burst. (PubMed id 9886420)9 Dri P....Patriarca P. (J. Immunol. 1999)
    788. The Fanconi anemia group C gene product modulates apoptotic responses to tumor necrosis factor-alpha and Fas ligand but does not suppress expression of receptors of the tumor necrosis factor receptor superfamily. (PubMed id 9923438)9 Koh P.S....Bagby G.C. (Exp. Hematol. 1999)
    789. Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF. (PubMed id 10357816)9 Grell M....Strasser A. (EMBO J. 1999)
    790. Detection of macrophage inflammatory protein (MIP)-1alpha and MIP-1beta during experimental endotoxemia and human sepsis. (PubMed id 9841832)9 O'Grady N.P....Suffredini A.F. (J. Infect. Dis. 1999)
    791. Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis. (PubMed id 10090426)9 Goldenberg M.M. (Clin Ther 1999)
    792. A p75 tumor necrosis factor receptor-specific mutant of murine tumor necrosis factor alpha expressed from an adenovirus vector induces an antitumor response with reduced toxicity. (PubMed id 10505857)9 Marr R.A....Graham F.L. (Cancer Gene Ther. 1999)
    793. Plasma levels of the soluble fraction of tumor necrosis factor receptor 2 and insulin resistance. (PubMed id 9792545)9 FernA!ndez-Real J.M....Richart C. (Diabetes 1998)
    794. Multiple sclerosis: expression of molecules of the tumor necrosis factor ligand and receptor families in relationship to the demyelinated plaque. (PubMed id 9809372)9 Raine C.S....Cannella B. (Rev. Neurol. (Paris) 1998)
    795. Soluble tumor necrosis factor receptor (p75) fusion protein (ENBREL) as a therapy for rheumatoid arthritis. (PubMed id 9710888)9 Moreland L.W. (Rheum. Dis. Clin. North Am. 1998)
    796. Neural architecture in transected rabbit sciatic nerve after prolonged nonreinnervation. (PubMed id 9723980)9 Bradley J.L....Thomas P.K. (J. Anat. 1998)
    797. Shedding of tumour necrosis factor receptors from purified villous term trophoblasts and cytotrophoblastic BeWo cells. (PubMed id 9756317)9 KnAPfler M....Husslein P. (Hum. Reprod. 1998)
    798. The mRNA expression of cytokines and their receptors in cultured iris pigment epithelial cells: a comparison with retinal pigment epithelial cells. (PubMed id 9733590)9 Kociok N....Heimann K. (Exp. Eye Res. 1998)
    799. Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. (PubMed id 9500555)9 Relaix F....Sassoon D.A. (Nat. Genet. 1998)
    800. Induction of tumour necrosis factor (TNF) receptor type p55 and p75 in patients with chronic hepatitis C virus (HCV) infection. (PubMed id 9486392)9 Kallinowski B....Rossol S. (Clin. Exp. Immunol. 1998)
    801. Gene expression by single Reed-Sternberg cells: pathways of apoptosis and activation. (PubMed id 9516144)9 Messineo C....Cossman J. (Blood 1998)
    802. TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. (PubMed id 9626059)9 Krajewska M.... Reed J.C. (Am. J. Pathol. 1998)
    803. Cloning and sequencing of cDNA encoding bovine tumor necrosis factor (TNF)-receptor I. (PubMed id 9613449)9 Lee E.K....Taylor M.J. (Vet. Immunol. Immunopathol. 1998)
    804. Neurotrophins: the biological paradox of survival factors eliciting apoptosis. (PubMed id 10200484)9 Casaccia-Bonnefil P....Chao M.V. (Cell Death Differ. 1998)
    805. Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor. (PubMed id 10023437)9 Mageed R.A....Chernajovsky Y. (Gene Ther. 1998)
    806. The influence of human endotoxemia on CD95-induced apoptosis. (PubMed id 9865650)9 Lin E....Lowry S.F. (Arch Surg 1998)
    807. A metalloproteinase inhibitor blocks the shedding of soluble cytokine receptors and processing of transmembrane cytokine precursors in human monocytic cells. (PubMed id 9195133)9 Gallea-Robache S....Roman-Roman S. (Cytokine 1997)
    808. Analysis of myeloid-associated genes in human hematopoietic progenitor cells. (PubMed id 9328452)9 Bello-FernA!ndez C....Knapp W. (Exp. Hematol. 1997)
    809. A matrix metalloproteinase inhibitor prevents processing of tumor necrosis factor alpha (TNF alpha) and abrogates endotoxin-induced lethality. (PubMed id 9185243)9 Solorzano C.C....Moldawer L.L. (Shock 1997)
    810. Polymorphisms of tumor necrosis factor receptor 2 are not associated with insulin-dependent diabetes mellitus or Graves' disease. (PubMed id 9174153)9 Rau H....Badenhoop K. (Tissue Antigens 1997)
    811. Neurotrophins and their receptors in nerve injury and repair. (PubMed id 9106250)9 Ebadi M....Lassi N.K. (Neurochem. Int. 1997)
    812. Involvement of a common 10-amino-acid segment in the cytoplasmic region of CD40 but different MAP kinases in different CD40-mediated responses. (PubMed id 9144420)9 Hara T....Uede T. (Biochem. Biophys. Res. Commun. 1997)
    813. A recombinant tumor necrosis factor-alpha p80 receptor:Fc fusion protein decreases circulating bioactive tumor necrosis factor-alpha but not lung injury or mortality during immunosuppression-related gram-negative bacteremia. (PubMed id 9075062)9 Lechner A.J....Matuschak G.M. (J Crit Care 1997)
    814. A differential role for interleukin-6 and tumor necrosis factor-alpha in schizophrenia? (PubMed id 9323355)9 Naudin J....Azorin J.M. (Schizophr. Res. 1997)
    815. [Neurotrophic factors and their receptor expressions in human neuropathies]. (PubMed id 9577659)9 Sobue G. (Rinsho Shinkeigaku 1997)

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    Entrez Gene: 7133 HGNC: 11917 AceView: TNFRSF1B Ensembl:ENSG00000028137 euGenes: HUgn7133
    ECgene: TNFRSF1B Kegg: 7133 H-InvDB: TNFRSF1B

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