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Aliases for TNFRSF1B Gene

Aliases for TNFRSF1B Gene

  • Tumor Necrosis Factor Receptor Superfamily Member 1B 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 1B 2 3
  • Tumor Necrosis Factor Receptor Type II 3 4
  • Tumor Necrosis Factor Receptor 2 3 4
  • P80 TNF-Alpha Receptor 3 4
  • TNF-RII 3 4
  • TNF-R2 3 4
  • TNFR2 3 4
  • TNFBR 3 4
  • P75 3 4
  • Tumor Necrosis Factor Binding Protein 2 3
  • Tumor Necrosis Factor Beta Receptor 3
  • Soluble TNFR1B Variant 1 3
  • P75 TNF Receptor 3
  • CD120b Antigen 4
  • Etanercept 4
  • TNF-R-II 3
  • TNF-R75 3
  • P75TNFR 3
  • TNFR-II 4
  • CD120b 3
  • TNFR1B 3
  • TNFR80 3
  • TBPII 3

External Ids for TNFRSF1B Gene

Previous HGNC Symbols for TNFRSF1B Gene

  • TNFR2

Previous GeneCards Identifiers for TNFRSF1B Gene

  • GC01P012291
  • GC01P012071
  • GC01P011836
  • GC01P011936
  • GC01P012161
  • GC01P011380
  • GC01P012227

Summaries for TNFRSF1B Gene

Entrez Gene Summary for TNFRSF1B Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF1B Gene

TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily Member 1B) is a Protein Coding gene. Diseases associated with TNFRSF1B include Classic Mycosis Fungoides and Sezary's Disease. Among its related pathways are TNF Signaling (sino) and TNF signaling pathway. GO annotations related to this gene include ubiquitin protein ligase binding and tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF14.

UniProtKB/Swiss-Prot for TNFRSF1B Gene

  • Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Gene Wiki entry for TNFRSF1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF1B Gene

Genomics for TNFRSF1B Gene

Regulatory Elements for TNFRSF1B Gene

Enhancers for TNFRSF1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TNFRSF1B on UCSC Golden Path with GeneCards custom track

Promoters for TNFRSF1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNFRSF1B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TNFRSF1B gene promoter:

Genomic Location for TNFRSF1B Gene

Chromosome:
1
Start:
12,166,949 bp from pter
End:
12,209,228 bp from pter
Size:
42,280 bases
Orientation:
Plus strand

Genomic View for TNFRSF1B Gene

Genes around TNFRSF1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF1B Gene

Proteins for TNFRSF1B Gene

  • Protein details for TNFRSF1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20333-TNR1B_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 1B
    Protein Accession:
    P20333
    Secondary Accessions:
    • B1AJZ3
    • Q16042
    • Q6YI29
    • Q9UIH1

    Protein attributes for TNFRSF1B Gene

    Size:
    461 amino acids
    Molecular mass:
    48291 Da
    Quaternary structure:
    • Binds to TRAF2. Interacts with BMX.

    Three dimensional structures from OCA and Proteopedia for TNFRSF1B Gene

    Alternative splice isoforms for TNFRSF1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFRSF1B Gene

Proteomics data for TNFRSF1B Gene at MOPED

Post-translational modifications for TNFRSF1B Gene

  • A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
  • Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
  • Glycosylation at Thr 30, Asn 171, Asn 193, Thr 206, Ser 221, and Thr 222
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFRSF1B (TNF RII/TNFRSF1B)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF1B (TNF-R2)

No data available for DME Specific Peptides for TNFRSF1B Gene

Domains & Families for TNFRSF1B Gene

Protein Domains for TNFRSF1B Gene

Graphical View of Domain Structure for InterPro Entry

P20333

UniProtKB/Swiss-Prot:

TNR1B_HUMAN :
  • Contains 4 TNFR-Cys repeats.
Similarity:
  • Contains 4 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF1B: view

Function for TNFRSF1B Gene

Molecular function for TNFRSF1B Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 1B,deleted in neuroblastoma,associated with susceptibility to systemic lupus erythematosus
UniProtKB/Swiss-Prot Function:
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
genes like me logo Genes that share phenotypes with TNFRSF1B: view

Animal Models for TNFRSF1B Gene

MGI Knock Outs for TNFRSF1B:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF1B Gene

Localization for TNFRSF1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF1B Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Tumor necrosis factor-binding protein 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFRSF1B Gene COMPARTMENTS Subcellular localization image for TNFRSF1B gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 3
cytosol 2
cytoskeleton 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TNFRSF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
GO:0043025 neuronal cell body IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with TNFRSF1B: view

Pathways & Interactions for TNFRSF1B Gene

genes like me logo Genes that share pathways with TNFRSF1B: view

Pathways by source for TNFRSF1B Gene

SIGNOR curated interactions for TNFRSF1B Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TNFRSF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA,IBA --
GO:0007275 multicellular organism development IBA --
GO:0007568 aging IEA --
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA --
GO:0032496 response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with TNFRSF1B: view

Drugs & Compounds for TNFRSF1B Gene

(41) Drugs for TNFRSF1B Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Etanercept Approved, Investigational Pharma Target 389
Infliximab Approved Pharma 358
tumour necrosis factor membrane form Pharma 0
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
CYT-6091 Pharma 0

(44) Additional Compounds for TNFRSF1B Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
lymphotoxin-alpha
genes like me logo Genes that share compounds with TNFRSF1B: view

Transcripts for TNFRSF1B Gene

Unigene Clusters for TNFRSF1B Gene

Tumor necrosis factor receptor superfamily, member 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF1B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for TNFRSF1B Gene

GeneLoc Exon Structure for
TNFRSF1B
ECgene alternative splicing isoforms for
TNFRSF1B

Expression for TNFRSF1B Gene

mRNA expression in normal human tissues for TNFRSF1B Gene

mRNA differential expression in normal tissues according to GTEx for TNFRSF1B Gene

This gene is overexpressed in Whole Blood (x24.5).

Protein differential expression in normal tissues from HIPED for TNFRSF1B Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF1B Gene



SOURCE GeneReport for Unigene cluster for TNFRSF1B Gene Hs.256278

genes like me logo Genes that share expression patterns with TNFRSF1B: view

Protein tissue co-expression partners for TNFRSF1B Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TNFRSF1B Gene

Orthologs for TNFRSF1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TNFRSF1B 35
  • 78.19 (n)
  • 70.93 (a)
TNFRSF1B 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNFRSF1B 35
  • 79.89 (n)
  • 72.62 (a)
TNFRSF1B 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnfrsf1b 35
  • 74.25 (n)
  • 64.11 (a)
Tnfrsf1b 16
Tnfrsf1b 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF1B 35
  • 96.4 (n)
  • 95.81 (a)
TNFRSF1B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfrsf1b 35
  • 72.65 (n)
  • 62.8 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia TNFRSF1B 36
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNFRSF1B 35
  • 45.34 (n)
  • 35.78 (a)
TNFRSF1B 36
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tnfrsf1b 36
  • 26 (a)
OneToOne
Species with no ortholog for TNFRSF1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF1B Gene

ENSEMBL:
Gene Tree for TNFRSF1B (if available)
TreeFam:
Gene Tree for TNFRSF1B (if available)

Paralogs for TNFRSF1B Gene

Paralogs for TNFRSF1B Gene

(3) SIMAP similar genes for TNFRSF1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TNFRSF1B: view

Variants for TNFRSF1B Gene

Sequence variations from dbSNP and Humsavar for TNFRSF1B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1061622 - 12,192,898(+) AAGCA(G/T)GGATG reference, missense
rs5746026 - 12,193,005(+) CTCCA(A/G)AACCC reference, missense
rs2228494 - 12,192,870(+) GTAAC(A/G)TGGTG reference, missense
rs5746027 - 12,193,017(+) GCACT(A/G)CTCCA reference, missense
rs2229700 - 12,193,958(+) AGGAC(C/T)GATTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF1B Gene

Variant ID Type Subtype PubMed ID
nsv469830 CNV Complex 16826518
nsv508891 CNV Insertion 20534489
nsv471622 CNV Gain+Loss 15918152
dgv143n71 CNV Gain 21882294
nsv527024 CNV Loss 19592680
nsv870819 CNV Gain 21882294
nsv871005 CNV Gain 21882294
dgv144n71 CNV Loss 21882294
nsv871537 CNV Loss 21882294
nsv871714 CNV Loss 21882294

Variation tolerance for TNFRSF1B Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.95; 79.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF1B Gene

Human Gene Mutation Database (HGMD)
TNFRSF1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF1B Gene

Disorders for TNFRSF1B Gene

MalaCards: The human disease database

(69) MalaCards diseases for TNFRSF1B Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
classic mycosis fungoides
  • mycosis fungoides, alibert-bazin type
sezary's disease
  • sezary disease
bone inflammation disease
  • bone inflammatory disease
juvenile rheumatoid arthritis
  • rheumatoid arthritis, systemic juvenile
scleral disease
  • scleral diseases
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFRSF1B

Genetic Association Database (GAD)
TNFRSF1B
Human Genome Epidemiology (HuGE) Navigator
TNFRSF1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFRSF1B
genes like me logo Genes that share disorders with TNFRSF1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF1B Gene

Publications for TNFRSF1B Gene

  1. Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism. (PMID: 12161545) Peral B. … Escobar-Morreale H.F. (J. Clin. Endocrinol. Metab. 2002) 3 4 23 48 67
  2. Genetic determinants of circulating levels of tumor necrosis factor receptor II and their association with TNF-RII gene polymorphisms. (PMID: 20488723) Vistoropsky Y. … Livshits G. (Cytokine 2010) 3 23
  3. FOXO3a regulates oxygen-responsive expression of tumor necrosis factor receptor 2 in human dermal microvascular endothelial cells. (PMID: 19473970) Ding B. … Pober J.S. (J. Biol. Chem. 2009) 3 23
  4. Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design. (PMID: 19557004) Eguchi T. … Saruta T. (Hypertens. Res. 2009) 3 23
  5. Single nucleotide polymorphisms in TNF-alpha, TNFR2 gene and TNF-alpha production in Asian Indians. (PMID: 19811435) Gupta R. … Das S.N. (Immunol. Invest. 2009) 3 23

Products for TNFRSF1B Gene

Sources for TNFRSF1B Gene

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