Aliases for TNFRSF1B Gene
Aliases for TNFRSF1B Gene
- TNF Receptor Superfamily Member 1B 2 3 5
- Tumor Necrosis Factor Receptor Type II 3 4
- Tumor Necrosis Factor Receptor 2 3 4
- P80 TNF-Alpha Receptor 3 4
- TNF-RII 3 4
- TNF-R2 3 4
- TNFR2 3 4
- TNFBR 3 4
- P75 3 4
- Tumor Necrosis Factor Receptor Superfamily, Member 1B 2
- Tumor Necrosis Factor Receptor Superfamily Member 1B 3
- Tumor Necrosis Factor Binding Protein 2 3
- Tumor Necrosis Factor Beta Receptor 3
External Ids for TNFRSF1B Gene
- HGNC: 11917
- Entrez Gene: 7133
- Ensembl: ENSG00000028137
- OMIM: 191191
- UniProtKB: P20333
Previous HGNC Symbols for TNFRSF1B Gene
- TNFR2
Previous GeneCards Identifiers for TNFRSF1B Gene
- GC01P012291
- GC01P012071
- GC01P011836
- GC01P011936
- GC01P012161
- GC01P011380
- GC01P012227
Summaries for TNFRSF1B Gene
-
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF1B Gene
TNFRSF1B (TNF Receptor Superfamily Member 1B) is a Protein Coding gene. Diseases associated with TNFRSF1B include Mycosis Fungoides and Sezary's Disease. Among its related pathways are PEDF Induced Signaling and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF21.
UniProtKB/Swiss-Prot for TNFRSF1B Gene
-
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Additional gene information for TNFRSF1B Gene
- Monarch Initiative
- Search for TNFRSF1B at DataMed
- Search for TNFRSF1B at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF1B Gene
Genomics for TNFRSF1B Gene
GeneHancer (GH) Regulatory Elements for TNFRSF1B Gene
Promoters and enhancers for TNFRSF1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TNFRSF1B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TNFRSF1B Gene
Genomic Locations for TNFRSF1B Gene
- chr1:12,166,949-12,209,228
- (GRCh38/hg38)
- Size:
- 42,280 bases
- Orientation:
- Plus strand
- chr1:12,227,060-12,269,285
- (GRCh37/hg19)
Genomic View for TNFRSF1B Gene
Genes around TNFRSF1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.22 by Ensembl
- 1p36.22 by Entrez Gene
- 1p36.22 by HGNC
TNFRSF1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TNFRSF1B Gene
Proteins for TNFRSF1B Gene
-
Protein details for TNFRSF1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20333-TNR1B_HUMAN
- Recommended name:
- Tumor necrosis factor receptor superfamily member 1B
- Protein Accession:
- P20333
- B1AJZ3
- Q16042
- Q6YI29
- Q9UIH1
Protein attributes for TNFRSF1B Gene
- Size:
- 461 amino acids
- Molecular mass:
- 48291 Da
- Quaternary structure:
-
- Binds to TRAF2. Interacts with BMX.
Protein Expression for TNFRSF1B Gene
Post-translational modifications for TNFRSF1B Gene
- A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
- Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
- Glycosylation at isoforms=230, isoforms=2171, posLast=193193, isoforms=2206, isoforms=2221, and isoforms=2222
Other Protein References for TNFRSF1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TNFRSF1B (TNF RII/TNFRSF1B)
- Cell Signaling Technology (CST) Antibodies for TNFRSF1B (TNF-R2)
-
Custom Antibody ServicesOriGene Antibodies for TNFRSF1B
- AM01240PU-N
- AM20827PU-L
- AM20827PU-N
- AM20827PU-S
- TA347564
- TA347563
- TA328459
- TA326923
- TA321270
- TA321269
- TA311834
- PP1222P2
- PP1222P1
- PP1222B2
- PP1222B1
- BM4054X
- BM4054B
- BM4054
- AP33327SU-S
- AP33327SU-N
- AP31209PU-N
- AP26380PU-N
- AP23408PU-N
- AM26300PU-N
- AM26300FC-N
- AM26300BT-N
- AM26290PU-N
- AM26290FC-N
- AM26290BT-N
- Novus Biologicals Antibodies for TNFRSF1B
-
Abcam antibodies for TNFRSF1B
-
Cloud-Clone Corp. Antibodies for TNFRSF1B
- Invitrogen Antibodies for TNFRSF1B
- antibodies-online: Search results for 293 available TNFRSF1B Antibodies ranked by validation data
- Compare Top TNFRSF1B Antibodies
-
Recommended
- 105 WB Antibodies (anti-human)
- 34 FACS Antibodies (anti-human)
- 16 IHC (fro) Antibodies (anti-human)
- 9 IP Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 90 WB Antibodies (anti-mouse)
- 24 FACS Antibodies (anti-mouse)
- 6 IP Antibodies (anti-mouse)
- 3 Neut Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 CC Antibody (anti-mouse)
- 1 ICFC Antibody (anti-mouse)
- 2 IHC (p) Antibodies (anti-rat)
- 5 IP Antibodies (anti-rat)
- 42 WB Antibodies (anti-rat)
- GeneTex TNFRSF1B antibody for TNFRSF1B
-
Santa Cruz Biotechnology (SCBT) Antibodies for TNFRSF1B
- Sino Biological Antibodies for TNFRSF1B
Protein Products
- R&D Systems Proteins and Enzymes for TNFRSF1B (TNF RII/TNFRSF1B)
-
OriGene Purified Proteins for TNFRSF1B
- Search Origene for MassSpec and Protein Over-expression Lysates for TNFRSF1B
- Origene Custom Protein Services for TNFRSF1B
- Sino Biological Cell Lysates for TNFRSF1B
- Sino Biological Recombinant Proteins for TNFRSF1B
- ProSpec Recombinant Proteins for TNFRSF1B
-
Cloud-Clone Corp. Proteins for TNFRSF1B
- GeneTex Proteins for TNFRSF1B
-
ProSci Proteins for TNFRSF1B
- "tumor necrosis factor receptor superfamily, member 1B" [96-731]
- tumor necrosis factor receptor superfamily member 1B [92-700]
- "tumor necrosis factor receptor superfamily, member 1B" [40-304]
- tumor necrosis factor receptor superfamily member 1B [92-344]
- tumor necrosis factor receptor superfamily member 1B [91-624]
-
Abcam proteins for TNFRSF1B
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for TNFRSF1B
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for TNFRSF1B (TNF RII/TNFRSF1B)
-
Cloud-Clone Corp. Assay Kits for TNFRSF1B
-
Abcam assays for TNFRSF1B
- Sino Biological Assays for TNFRSF1B
No data available for DME Specific Peptides for TNFRSF1B Gene
Domains & Families for TNFRSF1B Gene
Gene Families for TNFRSF1B Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- CD markers
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for TNFRSF1B Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TNFRSF1B Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TNFRSF1B Gene
Function for TNFRSF1B Gene
Molecular function for TNFRSF1B Gene
- GENATLAS Biochemistry:
- tumor necrosis factor receptor superfamily,member 1B,deleted in neuroblastoma,associated with susceptibility to systemic lupus erythematosus
- UniProtKB/Swiss-Prot Function:
- Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Phenotypes From GWAS Catalog for TNFRSF1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005031 | tumor necrosis factor-activated receptor activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 8069916 |
| GO:0031625 | ubiquitin protein ligase binding | IPI | 11279055 |
Phenotypes for TNFRSF1B Gene
- MGI mutant phenotypes for TNFRSF1B:
-
inferred from 3 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- integument phenotype
- hematopoietic system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for TNFRSF1B:
Animal Models for TNFRSF1B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TNFRSF1B
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TNFRSF1B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TNFRSF1B gene
- Search ViGene Biosciences for TNFRSF1B
CRISPR Products
-
OriGene CRISPR knockouts for TNFRSF1B
- genomics-online: gRNA clones - Search results for 127 available TNFRSF1B gene related products
- Overview of 127 available TNFRSF1B gene related products
- Applied Biological Materials CRISPR for TNFRSF1B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNFRSF1B
- GenScript: Design CRISPR guide RNA sequences for TNFRSF1B
miRNA for TNFRSF1B Gene
- miRTarBase miRNAs that target TNFRSF1B
-
- hsa-mir-193a-3p (MIRT129887)
- hsa-mir-193b-3p (MIRT129893)
- hsa-mir-19a-3p (MIRT129958)
- hsa-mir-19b-3p (MIRT129959)
- hsa-mir-6852-3p (MIRT717187)
- hsa-mir-3909 (MIRT717188)
- hsa-mir-6891-3p (MIRT717189)
- hsa-mir-6072 (MIRT717190)
- hsa-mir-6884-3p (MIRT717191)
- hsa-mir-3607-5p (MIRT717192)
- hsa-mir-299-3p (MIRT717193)
- hsa-mir-96-3p (MIRT717194)
miRNA Products
- Search ViGene Biosciences for TNFRSF1B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TNFRSF1B
- Browse OriGene Inhibitory RNA Products For TNFRSF1B
- genomics-online: shRNA clones - Search results for 127 available TNFRSF1B gene related products
- Overview of 127 available TNFRSF1B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TNFRSF1B gene
Clone Products
-
OriGene ORF clones in human for TNFRSF1B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TNFRSF1B
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TNFRSF1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TNFRSF1B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TNFRSF1B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for TNFRSF1B (TNF RII/TNFRSF1B)
Cell Line Products
-
Horizon Cell Lines for TNFRSF1B
-
ViGene Biosciences adenoviral particle packaged cDNA for TNFRSF1B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TNFRSF1B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TNFRSF1B gene
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNFRSF1B Gene
Localization for TNFRSF1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF1B Gene
- Isoform 1: Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Secreted.
- Tumor necrosis factor-binding protein 2: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 3 |
| cytosol | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFRSF1B Gene
Pathways & Interactions for TNFRSF1B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.47
|
|
| 2 | TGF-Beta Pathway |
.60
|
.57
.51
|
| 3 | Akt Signaling |
.60
.60
|
|
| 4 | TNFR1 Pathway |
.55
|
|
| 5 | Innate Immune System |
.61
|
|
Pathways by source for TNFRSF1B Gene
2 Cell Signaling Technology pathways for TNFRSF1B Gene
5 BioSystems pathways for TNFRSF1B Gene
9 Reactome pathways for TNFRSF1B Gene
4 KEGG pathways for TNFRSF1B Gene
4 GeneGo (Thomson Reuters) pathways for TNFRSF1B Gene
1 R&D Systems pathway for TNFRSF1B Gene
28 Qiagen pathways for TNFRSF1B Gene
Interacting Proteins for TNFRSF1B Gene
Selected Interacting proteins:
P20333-TNR1B_HUMAN
ENSP00000365435
for TNFRSF1B Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006954 | inflammatory response | IBA | -- |
| GO:0006955 | immune response | IEA,IBA | -- |
| GO:0007166 | cell surface receptor signaling pathway | IEA | -- |
| GO:0007275 | multicellular organism development | IBA | -- |
Drugs & Compounds for TNFRSF1B Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| lymphotoxin-alpha |
|
|
|
Transcripts for TNFRSF1B Gene
mRNA/cDNA for TNFRSF1B Gene
- (8) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (183) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TNFRSF1B Gene
CRISPR Products
-
OriGene CRISPR knockouts for TNFRSF1B
- genomics-online: gRNA clones - Search results for 127 available TNFRSF1B gene related products
- Overview of 127 available TNFRSF1B gene related products
- Applied Biological Materials CRISPR for TNFRSF1B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNFRSF1B
- GenScript: Design CRISPR guide RNA sequences for TNFRSF1B
miRNA Products
- Search ViGene Biosciences for TNFRSF1B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TNFRSF1B
- Browse OriGene Inhibitory RNA Products For TNFRSF1B
- genomics-online: shRNA clones - Search results for 127 available TNFRSF1B gene related products
- Overview of 127 available TNFRSF1B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TNFRSF1B gene
Clone Products
-
OriGene ORF clones in human for TNFRSF1B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TNFRSF1B
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TNFRSF1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TNFRSF1B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TNFRSF1B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for TNFRSF1B (TNF RII/TNFRSF1B)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: |
Expression for TNFRSF1B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- T Helper Cells Thymus
- Double Positive Thymocytes Thymus
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- Double Positive Thymocytes Thymus
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells
- Neural Crest (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
- Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for TNFRSF1B Gene
This gene is overexpressed in Whole Blood (x24.5).
This gene is overexpressed in CD8 Tcells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF1B Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TNFRSF1B Gene:
TNFRSF1BSOURCE GeneReport for Unigene cluster for TNFRSF1B Gene:
Hs.256278Evidence on tissue expression from TISSUES for TNFRSF1B Gene
- Nervous system(4.5)
- Urine(4.2)
- Blood(3.5)
- Intestine(2.8)
- Skin(2.8)
- Spleen(2.7)
- Bone marrow(2.6)
- Lymph node(2.6)
- Lung(2.5)
- Heart(2.4)
- Liver(2.4)
- Muscle(2.2)
- Kidney(2)
- Pancreas(2)
Primer Products
-
OriGene qPCR primer pairs for TNFRSF1B
-
OriGene qPCR primer pairs and template standards for TNFRSF1B
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF1B Gene
Orthologs for TNFRSF1B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TNFRSF1B 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TNFRSF1B 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TNFRSF1B 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tnfrsf1b 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tnfrsf1b 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TNFRSF1B 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TNFRSF1B 33 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tnfrsf1b 34 |
|
OneToOne |
- Species where no ortholog for TNFRSF1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TNFRSF1B Gene
Variants for TNFRSF1B Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000021009 | -- | 12,169,090(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000128688 | -- | 12,188,559(+) | A/C | intron_variant | |
| rs1000211263 | -- | 12,206,381(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000319007 | -- | 12,199,838(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000414082 | -- | 12,199,513(+) | C/G | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv112n54 | CNV | loss | 21841781 |
| dgv113n54 | CNV | loss | 21841781 |
| esv3584475 | CNV | gain | 24956385 |
| nsv1145321 | CNV | deletion | 24896259 |
| nsv469830 | CNV | loss | 16826518 |
| nsv471622 | CNV | gain+loss | 15918152 |
| nsv508891 | CNV | insertion | 20534489 |
| nsv527024 | CNV | loss | 19592680 |
| nsv545437 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.95;
79.83% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TNFRSF1B Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF1B Gene
Disorders for TNFRSF1B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mycosis fungoides |
|
|
| sezary's disease |
|
|
| juvenile rheumatoid arthritis |
|
|
| esophageal tuberculosis |
|
|
| orbital plasma cell granuloma |
|
|
Search TNFRSF1B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TNFRSF1B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF1B Gene
Publications for TNFRSF1B Gene
- Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism. (PMID: 12161545) Peral B … Escobar-Morreale HF (The Journal of clinical endocrinology and metabolism 2002) 3 4 22 44 58
- Association of tumor necrosis factor receptor type II polymorphism 196R with Systemic lupus erythematosus in the Japanese: molecular and functional analysis. (PMID: 11762942) Morita C … Niho Y (Arthritis and rheumatism 2001) 3 4 22 44 58
- New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus. (PMID: 11197692) Tsuchiya N … Tokunaga K (Genes and immunity 2000) 3 4 22 44 58
- Single nucleotide polymorphisms in TNF-alpha, TNFR2 gene and TNF-alpha production in Asian Indians. (PMID: 19811435) Gupta R … Das SN (Immunological investigations 2009) 3 22 44 58
- Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design. (PMID: 19557004) Eguchi T … Saruta T (Hypertension research : official journal of the Japanese Society of Hypertension 2009) 3 22 44 58
Products for TNFRSF1B Gene
- R&D Systems Antibodies for TNFRSF1B (TNF RII/TNFRSF1B)
- R&D Systems Proteins and Enzymes for TNFRSF1B (TNF RII/TNFRSF1B)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for TNFRSF1B (TNF RII/TNFRSF1B)
- R&D Systems cDNA Clones for TNFRSF1B (TNF RII/TNFRSF1B)
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- Custom Antibody ServicesOriGene Antibodies for TNFRSF1B
- AM01240PU-N
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- AP23408PU-N
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- AP33327SU-N
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- BM4054
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- PP1222B1
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- Custom Assay ServicesOriGene ELISA Kits for TNFRSF1B
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- OriGene CRISPR knockouts for TNFRSF1B
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TNFRSF1B
- GenScript: Next-day shipping of latest version cDNA ORF clones for TNFRSF1B in any vector
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- Cell Signaling Technology (CST) Antibodies for TNFRSF1B (TNF-R2)
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- Sino Biological Human cDNA Clone for TNFRSF1B
- Sino Biological Cell Lysates for TNFRSF1B
- Sino Biological Recombinant Proteins for TNFRSF1B
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- Sino Biological Assays for TNFRSF1B
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- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for TNFRSF1B
- Novus Biologicals proteins and lysates for TNFRSF1B
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- Novus Biologicals Tissue Microarrays
- Abcam antibodies for TNFRSF1B
- Abcam proteins for TNFRSF1B
- Abcam assays for TNFRSF1B
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- ProSpec Recombinant Proteins for TNFRSF1B
- Cloud-Clone Corp. Antibodies for TNFRSF1B
- Cloud-Clone Corp. Proteins for TNFRSF1B
- Cloud-Clone Corp. Assay Kits for TNFRSF1B
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for TNFRSF1B
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for TNFRSF1B
- VectorBuilder custom plasmid, inducible vectors for TNFRSF1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TNFRSF1B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 293 available TNFRSF1B Antibodies ranked by validation data
- Compare Top TNFRSF1B Antibodies
- Recommended
- 105 WB Antibodies (anti-human)
- 34 FACS Antibodies (anti-human)
- 16 IHC (fro) Antibodies (anti-human)
- 9 IP Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 90 WB Antibodies (anti-mouse)
- 24 FACS Antibodies (anti-mouse)
- 6 IP Antibodies (anti-mouse)
- 3 Neut Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 CC Antibody (anti-mouse)
- 1 ICFC Antibody (anti-mouse)
- 42 WB Antibodies (anti-rat)
- 5 IP Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- antibodies-online: Search results for 51 available TNFRSF1B Elisa Kits ranked by validation data
- Compare Top TNFRSF1B Elisa Kits
- antibodies-online: Search results for 47 available TNFRSF1B Proteins ranked by validation data
- Compare Top TNFRSF1B Proteins
- GeneTex TNFRSF1B antibody for TNFRSF1B
- GeneTex Proteins for TNFRSF1B
- ViGene Biosciences adenoviral particle packaged cDNA for TNFRSF1B gene
- ViGene Biosciences lentiviral particle packaged cDNA for TNFRSF1B gene
- ViGene Biosciences ready-to-package AAV shRNAs for TNFRSF1B gene
- Search ViGene Biosciences for TNFRSF1B
- Santa Cruz Biotechnology (SCBT) Antibodies for TNFRSF1B
- Search Santa Cruz Biotechnology (SCBT) for TNFRSF1B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TNFRSF1B
- Search for TNFRSF1B Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for TNFRSF1B
- "tumor necrosis factor receptor superfamily, member 1B" [96-731]
- tumor necrosis factor receptor superfamily member 1B [91-624]
- tumor necrosis factor receptor superfamily member 1B [92-344]
- tumor necrosis factor receptor superfamily member 1B [92-700]
- "tumor necrosis factor receptor superfamily, member 1B" [40-304]
- Horizon Cell Lines for TNFRSF1B
- genomics-online: cdna clones - Search results for 127 available TNFRSF1B gene related products
- Overview of 127 available TNFRSF1B gene related products
- orf clones - Search results for 127 available TNFRSF1B gene related products
- Overview of 127 available TNFRSF1B gene related products
- genomics-online: gRNA clones - Search results for 127 available TNFRSF1B gene related products
- Overview of 127 available TNFRSF1B gene related products
- genomics-online: primer clones - Search results for 127 available TNFRSF1B gene related products
- Overview of 127 available TNFRSF1B gene related products
- genomics-online: shRNA clones - Search results for 127 available TNFRSF1B gene related products
- Overview of 127 available TNFRSF1B gene related products
Sources for TNFRSF1B Gene
- (1) GeneCards
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- (157) EPDnew