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TNFRSF1B Gene

protein-coding GIFtS: 71
GCID: GC01P012227

Tumor Necrosis Factor Receptor Superfamily, Member 1B

(Previous symbol: TNFR2)

Microbiology & Infectious Diseases Congress

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 1B¹ ²		TNF-R75²
TNFR2¹ ² ³ ⁵		TNFR1B²
TNFBR² ³ ⁵		TNFR80²
Tumor Necrosis Factor Receptor 2² ³		P75 TNF Receptor²
Tumor Necrosis Factor Receptor Type II² ³		p75TNFR²
TNF-R2² ³		Soluble TNFR1B Variant 1²
TNF-RII² ³		Tumor Necrosis Factor Beta Receptor²
p75² ³		Tumor Necrosis Factor Binding Protein 2²
P80 TNF-Alpha Receptor² ³		Tumor Necrosis Factor Receptor Superfamily Member 1B²
CD120b²		Etanercept³
TBPII²		TNFR-II³
TNF-R-II²		CD120b Antigen³

External Ids:	HGNC: 11917¹	Entrez Gene: 7133²	Ensembl: ENSG00000028137⁷	OMIM: 191191⁵	UniProtKB: P20333³

Export aliases for TNFRSF1B gene to outside databases

Previous GC identifers: GC01P012291 GC01P012071 GC01P011836 GC01P011936 GC01P012161 GC01P011380

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFRSF1B Gene:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form

a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3

ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought

to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2,

which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting

neurons from apoptosis by stimulating antioxidative pathways. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFRSF1B Gene:

TNFRSF1B (tumor necrosis factor receptor superfamily, member 1B) is a protein-coding gene. Diseases associated with TNFRSF1B include marek disease, and scleritis. GO annotations related to this gene include tumor necrosis factor-activated receptor activity and ubiquitin protein ligase binding. An important paralog of this gene is TNFRSF21.

UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333

Function: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for

homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3

to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks

TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological

activity

Gene Wiki entry for TNFRSF1B Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000001.11 NC_018912.2 NT_032977.10

Regulatory elements:

Regulatory transcription factor binding sites in the TNFRSF1B gene promoter:
AML1a STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNFRSF1B promoter sequence

Search Chromatin IP Primers for TNFRSF1B

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.22

TNFRSF1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF1B gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P012227: view genomic region (about GC identifiers)

Start:	12,227,060 bp from pter	End:	12,269,285 bp from pter
Size:	42,226 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 1B precursor

Size: 461 amino acids; 48291 Da

Subunit: Binds to TRAF2. Interacts with BMX

2 PDB 3D structures from and Proteopedia for TNFRSF1B:

1CA9 (3D)

3ALQ (3D)

Secondary accessions: B1AJZ3 Q16042 Q6YI29 Q9UIH1

Alternative splicing: 2 isoforms: P20333-1 P20333-2

Explore the universe of human proteins at neXtProt for TNFRSF1B: NX_P20333

Explore proteomics data for TNFRSF1B at MOPED

Post-translational modifications:

Phosphorylated; mainly on serine residues and with a very low level on threonine residues¹

A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic

processing¹

Glycosylation² at Asn171, Asn193, Ser208, Ser221, Thr222

Modification sites at PhosphoSitePlus

See TNFRSF1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001057.1

ENSEMBL proteins:

ENSP00000365435 ENSP00000440425

TNFRSF1B Human Recombinant Protein Products:

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	Browse Kits and Assays available from EMD Millipore
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	Cloud-Clone Corp. ELISAs for TNFRSF1B Cloud-Clone Corp. CLIAs for TNFRSF1B

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

CD: CD molecules

TNFRSF: Tumor necrosis factor receptor superfamily

IUPHAR Guide to PHARMACOLOGY protein family classification: tumor necrosis factor receptor 2

Tumour necrosis factor (TNF) receptor family

2 InterPro protein domains:

IPR001368 TNFR/NGFR_Cys_rich_reg

IPR020411 TNFR_1B

Graphical View of Domain Structure for InterPro Entry P20333

ProtoNet protein and cluster: P20333

1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333

Similarity: Contains 4 TNFR-Cys repeats

TNFRSF1B for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: TNR1B_HUMAN, P20333

Function: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for

homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3

to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks

TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological

activity

Genatlas biochemistry entry for TNFRSF1B:

tumor necrosis factor receptor superfamily,member 1B,deleted in neuroblastoma,associated with susceptibility to

systemic lupus erythematosus

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005031	tumor necrosis factor-activated receptor activity	IEA	--
GO:0005515	protein binding	IPI	10848577
GO:0031625	ubiquitin protein ligase binding	IPI	11279055

TNFRSF1B for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for TNFRSF1B:

Decreased Hepatitis C virus re

Selected MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tnfrsf1b) (see all 19):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	immune system	integument
liver/biliary system	mortality/aging	muscle	nervous system	renal/urinary system

TNFRSF1B for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for TNFRSF1B: Tnfrsf1b^tm1Imx Tnfrsf1b^tm1Mwm

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFRSF1B

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNFRSF1B

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF1B

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF1B

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		Selected qRT-PCR Assays for microRNAs that regulate TNFRSF1B (see all 37):
		hsa-miR-3938 hsa-let-7d hsa-miR-301a hsa-miR-486-3p hsa-let-7g hsa-let-7a hsa-miR-130b hsa-miR-301b

		SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF1B 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TNFRSF1B
		Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF1B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TNFRSF1B

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		GenScript: all cDNA clones in your preferred vector: TNFRSF1B (NM_001066)
		Sino Biological Human cDNA Clone for TNFRSF1B
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF1B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF1B

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		Browse ESI BIO Cell Lines and PureStem Progenitors for TNFRSF1B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF1B

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

TNR1B_HUMAN, P20333: Isoform 1: Cell membrane; Single-pass type I membrane protein

TNR1B_HUMAN, P20333: Isoform 2: Secreted

TNR1B_HUMAN, P20333: Tumor necrosis factor-binding protein 2: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
plasma membrane	5
nucleus	2
cytoskeleton	1
cytosol	1
golgi apparatus	1
mitochondrion	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0016020	membrane	--	--
GO:0016021	integral component of membrane	IEA	--

TNFRSF1B for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TNFRSF1B About (see all 29)

See pathways by source

SuperPath

Contained pathways About

TNF Signaling

	TNF Signaling	0.50			TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions	0.49
	Death Receptor Signaling	0.50			NF-kB (NFkB) Pathway	0.46

PEDF Induced Signaling

	PGC1Alpha Pathway	0.51			Glucocorticoid Receptor Signaling	0.43
	STAT3 Pathway	0.47			Cytokine-cytokine receptor interaction	0.43

TGF-Beta Pathway

	TGF-Beta Pathway	0.60			JAK-STAT Pathway	0.57
	MAPK Family Pathway	0.60			JNK Pathway	0.51

Akt Signaling

	Akt Signaling	0.60			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

NF-KappaB Family Pathway

NF-KappaB (p50-p65) Pathway

0.72

NF-KappaB Family Pathway

0.72

Pathways by source See SuperPaths
Show all pathways

3 R&D Systems Pathways for TNFRSF1B

	TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF1B (see all 28)

	Caspase Cascade
	MAPK Signaling
	THC Differentiation Pathway
	TRAF Pathway
	Molecular Mechanisms of Cancer

2 Cell Signaling Technology (CST) Pathways for TNFRSF1B

	Apoptosis and Autophagy
	NF-kappaB Signaling

4 GeneGo (Thomson Reuters) Pathways for TNFRSF1B

	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
	Apoptosis and survival Apoptotic TNF-family pathways
	Transcription NF-kB signaling pathway
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

Selected BioSystems Pathways for TNFRSF1B (see all 6)

	Apoptosis
	Apoptosis Modulation and Signaling
	TNF-alpha/NF-kB Signaling Pathway
	IL-3 Signaling Pathway
	TNF receptor signaling pathway

3 Sino Biological Pathways for TNFRSF1B

	TNF Signaling
	Death Receptor Signaling
	NF-kB (NFkB) Pathway

4 Kegg Pathways (Kegg details for TNFRSF1B):

	Cytokine-cytokine receptor interaction
	TNF signaling pathway
	Adipocytokine signaling pathway
	Amyotrophic lateral sclerosis (ALS)

TNFRSF1B for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including TNFRSF1B (see all 12):

HIV Host Response in human mouse rat

NFKB Signaling Targets in human mouse rat

Multiple Sclerosis in human mouse rat

Lymphoma in human mouse rat

Apoptosis in human mouse rat

Interactions:

GeneGlobe Interaction Network for TNFRSF1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TNFRSF1B (P20333^{1, 2, 3} ENSP00000365435⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 155)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000206439	P01375¹^,²^,³	EBI-358983,EBI-359977 MINT-48048 MINT-49370 I2D: score=10
ENSG00000223952	P01375¹^,²^,³	EBI-358983,EBI-359977 MINT-48048 MINT-49370 I2D: score=10
ENSG00000230108	P01375¹^,²^,³	EBI-358983,EBI-359977 MINT-48048 MINT-49370 I2D: score=10
ENSG00000204490	P01375¹^,²^,³, ENSP00000365290⁴	EBI-358983,EBI-359977 MINT-48048 MINT-49370 I2D: score=10 STRING: ENSP00000365290
TNF	P01375¹^,²^,³, ENSP00000398698⁴	EBI-358983,EBI-359977 MINT-48048 MINT-49370 I2D: score=10 STRING: ENSP00000398698

About this table

Gene Ontology (GO): Selected biological process terms (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	--	--
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	IEA	--
GO:0007166	cell surface receptor signaling pathway	--	--
GO:0007568	aging	IEA	--

TNFRSF1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for TNFRSF1B (TNR1B)

UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333

Pharmaceutical: Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe

rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an

immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors

1 DrugBank Compound for TNFRSF1B About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Etanercept	CD120b (see all 7)	185243-69-0	target	--	11752352

2 IUPHAR Ligands for TNFRSF1B (tumor necrosis factor receptor 2) About this table

Ligand	Type	Action	Affinity	Pubmed IDs
lymphotoxin-alpha	None	None		--
tumour necrosis factor membrane form	None	None		--

Selected Novoseek inferred chemical compound relationships for TNFRSF1B gene (see all 80) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
etanercept	69.4	34	11574988 (1), 12110156 (1), 16796629 (1), 10904249 (1) (see all 29)
infliximab	54.4	13	19370184 (2), 12110156 (1), 19136378 (1), 12421092 (1) (see all 10)
tapi	52.1	4	7869036 (2)
neopterin	48.3	9	9764776 (2), 15642275 (2), 16273760 (1), 10973464 (1) (see all 6)
gp 130	41.1	7	10575186 (2), 19631179 (1), 19107325 (1), 10414448 (1) (see all 5)
il 10	29.6	9	12011375 (3), 8891726 (1), 11508666 (1), 19186969 (1)
fmlp	29.4	8	7998940 (3), 8946217 (1), 9886420 (1)
endotoxin	27.9	5	1322942 (1), 7622886 (1), 17244513 (1), 9185243 (1) (see all 5)
rantes	26.8	8	11562425 (2), 11504986 (2), 10843668 (1), 12376864 (1) (see all 6)
cuprophan	25.7	2	16988495 (1), 11509797 (1)

TNFRSF1B for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TNFRSF1B gene:

NM_001066.2

Unigene Cluster for TNFRSF1B:

Tumor necrosis factor receptor superfamily, member 1B

Hs.256278 [show with all ESTs]

Unigene Representative Sequence: BC052977

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000376259(uc001att.3 uc009vnk.3) ENST00000492361(uc001atu.3)

ENST00000489921 ENST00000536782

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat TNFRSF1B using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TNFRSF1B (see all 37):
		hsa-miR-3938 hsa-let-7d hsa-miR-301a hsa-miR-486-3p hsa-let-7g hsa-let-7a hsa-miR-130b hsa-miR-301b

		SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF1B 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TNFRSF1B
		Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF1B

Clone Products:		OriGene clones in human, mouse for TNFRSF1B (see all 7) OriGene ORF clones in mouse, rat for TNFRSF1B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TNFRSF1B (NM_001066)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF1B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF1B

Primer Products:		OriGene qPCR primer pairs and template standards for TNFRSF1B OriGene qSTAR qPCR primer pairs in human, mouse for TNFRSF1B
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TNFRSF1B
		QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF1B
		QuantiFast Probe-based Assays in human, mouse, rat TNFRSF1B

Additional mRNA sequence:

AY148473.1 BC011844.2 BC042167.1 BC052977.1 BT019927.1 EU826615.1 M32315.1 M35857.1

M55994.1 S63368.1

7 DOTS entries:

DT.415651 DT.100823263 DT.100823260 DT.95169202 DT.100823259 DT.100823262 DT.101984571

Selected AceView cDNA sequences (see all 183):

AA533208 AI422018 CA435681 AW170706 AW468069 AA972749 BE466601 H26148

AI985195 BC011844 NM_001066 BQ690571 AI360418 CD610466 CD610462 BQ632532

BF222736 AI659001 BU158001 AI140025 T78122 AI632561 BE138861 AI762184

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF1B About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b
SP1:											-
SP2:											-										-		-
SP3:									-		-
SP4:

ECgene alternative splicing isoforms for TNFRSF1B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TNFRSF1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATGGAGCGCA

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TNFRSF1B expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 8) fully expand


Blood (Cardiovascular System) fully expand to see all 4 entries
Hematopoietic Stem Cells Hematopoietic Bone Marrow

Thymus (Hematopoietic System) fully expand to see all 2 entries
T Helper Cells Thymus

Bone (Muscoskeletal System) fully expand to see all 2 entries
Bone marrow-derived mesenchymal stem cells

Mesenchymal Stem Cells
Bone marrow-derived mesenchymal stem cells

Paraxial Mesoderm (Gastrulation Derivatives)
PureStem 7PEND24, NCr-fac & Meso-prx Progenitor

TNFRSF1B Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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TNFRSF1B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.256278

Pathway & Disease-focused RT² Profiler PCR Arrays including TNFRSF1B (see all 12):

HIV Host Response in human mouse rat

NFKB Signaling Targets in human mouse rat

Multiple Sclerosis in human mouse rat

Lymphoma in human mouse rat

Apoptosis in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for TNFRSF1B OriGene qSTAR qPCR primer pairs in human, mouse for TNFRSF1B
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF1B gene from Selected species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tnfrsf1b^{1 , 5}	tumor necrosis factor receptor superfamily, member more^{1, 5}	74.25(n)¹ 64.11(a)¹		4 (78.17 cM)⁵ 21938¹ NM_011610.3¹ NP_035740.2¹ 145213463⁵
chicken (Gallus gallus)	Aves	TNFRSF1B¹	tumor necrosis factor receptor superfamily, member more	45.34(n) 35.78(a)		395083 NM_204439.3 NP_989770.2
zebrafish (Danio rerio)	Actinopterygii	tnfrsf1b⁶	tumor necrosis factor receptor superfamily, member...	26(a)	1 ↔ 1	11(41910114-41933153) ENSDARG00000070165

ENSEMBL Gene Tree for TNFRSF1B (if available)
TreeFam Gene Tree for TNFRSF1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TNFRSF1B gene

TNFRSF21² TNFRSF11A² TNFRSF6B² LTBR² TNFRSF11B² TNFRSF14² CD40²

3 SIMAP similar genes for TNFRSF1B using alignment to 2 protein entries: TNR1B_HUMAN (see all proteins):

TNFR1B CD40 TNFRSF6B

TNFRSF1B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201734788^1,2	C	--	11396922(+)	`TATCT-/ATC TGTTTGTCTG`	1	--	int¹		0	--	--	--	--
rs149904799^1,2		--	11396963(+)	`TTATC-/TATTT TATCT`	1	--	int¹		0	--	--	--	--
rs3216795^1,2	C,F	--	11401495(+)	`TCACATG/-AGTGT`	1	--	int¹		4		NS CSA	244
rs113856503^1,2	C	--	11410251(+)	`TTTTTT/-CTTTC`	1	--	int¹		1		CSA	2
rs5746056^1,2	C,F	--	11415953(+)	`CTACTG/AATAAT`	1	--	int¹		8		NS NA WA EA	630
rs5746057^1,2	C,F,H	--	11415954(+)	`TACTGA/CTAATT`	1	--	int¹		9		NS EA NA	664
rs17882580^1,2	C,F	--	12229032(+)	`TCCCCC/-GCCTC`	1	--	int¹		2		NS	88
rs17879153^1,2	C,F	--	12230234(+)	`CATTCATTC/- CCCAA`	1	--	int¹		2		NS	94
rs61774888^1,2	F	--	12234229(+)	`CTTCTC/TCTTCT`	1	--	int¹		1		NA	2
rs61774889^1,2	F	--	12234235(+)	`CTTCTC/TCTTCT`	1	--	int¹		1		NA	2

HapMap Linkage Disequilibrium report for TNFRSF1B (12227060 - 12269285 bp)

Structural Variations
Database of Genomic Variants (DGV) 10 variations for TNFRSF1B: About this table

Variant ID	Type	Subtype	PubMed ID
nsv508891	CNV	Insertion	20534489
nsv871537	CNV	Loss	21882294
nsv527024	CNV	Loss	19592680
nsv871714	CNV	Loss	21882294
dgv144n71	CNV	Loss	21882294
dgv143n71	CNV	Gain	21882294
nsv871005	CNV	Gain	21882294
nsv870819	CNV	Gain	21882294
nsv471622	CNV	Gain+Loss	15918152
nsv469830	CNV	Complex	16826518

Human Gene Mutation Database (HGMD): TNFRSF1B

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TNFRSF1B

DNA2.0 Custom Variant and Variant Library Synthesis for TNFRSF1B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 191191 OMIM disorders: --

Selected diseases for TNFRSF1B (see all 188):
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marek disease scleritis palindromic rheumatism guillain-barre syndrome

post-transplant lymphoproliferative disease pneumococcal meningitis mixed connective tissue disease microscopic polyangiitis

narcolepsy exanthem paranoid schizophrenia hidradenitis

meningococcal infection hidradenitis suppurativa spondylitis q fever

ganglioneuroblastoma hemorrhagic fever with renal syndrome pneumoconiosis septic arthritis

18 diseases from the University of Copenhagen DISEASES database for TNFRSF1B:

Rheumatoid arthritis Psoriasis Psoriatic arthritis Ankylosing spondylitis

Crohn's disease Tuberculosis Hypersensitivity reaction type II disease Vasculitis

Uveitis Arthropathy Dermatitis Synovitis

Exanthem Hidradenitis suppurativa Sarcoidosis adult-onset Still's disease

Pneumonia Myositis

TNFRSF1B for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Selected Novoseek inferred disease relationships for TNFRSF1B gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	88.9	718	7573266 (5), 10561634 (4), 1324217 (3), 1655619 (2) (see all 99)
tumors	76.6	638	7573266 (5), 9669810 (4), 10561634 (4), 9677439 (3) (see all 99)
rheumatoid arthritis	63.4	46	9290265 (3), 10765919 (2), 15022314 (2), 15603867 (2) (see all 30)
inflammation	48.6	18	19343543 (1), 18848768 (1), 11156356 (1), 16947419 (1) (see all 16)
arthritis psoriatic	45	6	17502870 (1), 19222252 (1), 17394851 (1), 12011375 (1)
spondylitis ankylosing	43.4	4	19177266 (1), 11986408 (1), 17502870 (1), 17394851 (1)
fibroma shope	43.3	1	8590321 (1)
lupus erythematosus systemic	35.6	35	12739039 (3), 11762942 (2), 15642275 (2), 11197692 (2) (see all 18)
autoimmune diseases	32.2	7	11169260 (4), 17785864 (1), 20225650 (1), 10436260 (1)
shock septic	31	4	8627066 (1), 11084543 (1), 11253333 (1), 15526005 (1)

Genetic Association Database (GAD): TNFRSF1B
Human Genome Epidemiology (HuGE) Navigator: TNFRSF1B (154 documents)

Export disorders for TNFRSF1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TNFRSF1B gene, integrated from 10 sources (see all 863):
(articles sorted by number of sources associating them with TNFRSF1B)

Utopia: connect your pdf to the dynamic
world of online information

Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism. (PubMed id 12161545)^{1, 2, 4, 9} Peral B....Escobar-Morreale H.F. (J. Clin. Endocrinol. Metab. 2002)
Association of tumor necrosis factor receptor type II polymorphism 196R with systemic lupus erythematosus in the Japanese: molecular and functional analysis. (PubMed id 11762942)^{1, 2, 4, 9} Morita C.... Niho Y. (Arthritis Rheum. 2001)
New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus. (PubMed id 11197692)^{1, 2, 4, 9} Tsuchiya N.... Tokunaga K. (Genes Immun. 2000)
Bone structural effects of variation in the TNFRSF1B gene encoding the tumor necrosis factor receptor 2. (PubMed id 18038243)^{1, 4, 9} Mullin B.H....Wilson S.G. (Osteoporos Int 2008)
The biallelic variable number of tandem repeats of the tumor necrosis factor receptor 2 promoter in systemic lupus erythematosus. (PubMed id 12739039)^{1, 4, 9} Lee Y.H....Song G.G. (Rheumatol. Int. 2003)
Tumor necrosis factor receptor 2 gene (TNFRSF1B) in genetic basis of coronary artery disease. (PubMed id 11357933)^{1, 4, 9} Benjafield A.V....Morris B.J. (J. Mol. Med. 2001)
A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: a case-control study and a meta-analysis. (PubMed id 17028114)^{1, 4, 9} Horiuchi T....Harada M. (Ann. Rheum. Dis. 2007)
Association between TNFRSF1B polymorphisms and bone mineral density, bone loss and fracture. (PubMed id 15071724)^{1, 4, 9} Tasker P.N....Ralston S.H. (Osteoporos Int 2004)
Single nucleotide polymorphisms in TNF-alpha, TNFR2 gene and TNF-alpha production in Asian Indians. (PubMed id 19811435)^{1, 4, 9} Gupta R....Das S.N. (Immunol. Invest. 2009)
Polymorphisms of the tumor necrosis factor-alpha receptor 2 gene are associated with obesity phenotypes among 405 Caucasian nuclear families. (PubMed id 18685868)^{1, 4, 9} Zhao L.J....Deng H.W. (Hum. Genet. 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7133	HGNC: 11917	AceView: TNFRSF1B	Ensembl:ENSG00000028137	euGenes: HUgn7133
ECgene: TNFRSF1B	Kegg: 7133	H-InvDB: TNFRSF1B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TNFRSF1B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFRSF1B	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/tnfrsf1b/
NIEHS-SNPs	http://egp.gs.washington.edu/data/tnfrsf1b/
Enbrel	http://www.enbrel.com/index.jspx

Intellectual Property for TNFRSF1B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TNFRSF1B gene:
Search GeneIP for patents involving TNFRSF1B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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TNFRSF1B Gene

Tumor Necrosis Factor Receptor Superfamily, Member 1B

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TNFRSF1B (Gene Symbol)
Tumor Necrosis Factor Receptor Superfamily, Member 1B
TNFR2
TNFBR
Tumor Necrosis Factor Receptor 2
Tumor Necrosis Factor Receptor Type II
TNF-R2
TNF-RII
p75
P80 TNF-Alpha Receptor
CD120b
TBPII
TNF-R-II
TNF-R75
TNFR1B
TNFR80
P75 TNF Receptor
p75TNFR
Soluble TNFR1B Variant 1
Tumor Necrosis Factor Beta Receptor
Tumor Necrosis Factor Binding Protein 2
Tumor Necrosis Factor Receptor Superfamily Member 1B
Etanercept
TNFR-II
CD120b Antigen

Spondylitis Ankylosing
Dementia
Genetic Susceptibility
Parasitemia
Retinoblastoma
sepsis
essential hypertension
Endometriosis
Herpes Simplex
NEUROPATHY, PAINFUL
Colitis Ulcerative
Fibroma Shope
ADENOCARCINOMA LUNG
insulin sensitivity
Breast Cancer
Edema
primary tumor
Rheumatic Diseases
Schizophrenia
cell damage
Cancer
Lymphoma
Guillain-Barre Syndrome
effusion
Osteolysis
Colorectal Cancer
Multiple Sclerosis
Inflammation
Tuberculosis
Neutropenia
Hyperglycemia
Psoriasis
Anemia
MYELOMA
Renal Failure
Sarcoidosis
Rheumatoid Arthritis
Pneumonia
Tumors
Cardiovascular Diseases
Metastasis
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Fibrosarcoma
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Glioblastoma
Preeclampsia
Shock Septic
Colitis
Neurodegenerative Diseases
Encephalomyelitis
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BREAST CARCINOMA
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Vasculitis
Hyperplasia
Arthritis Juvenile Rheumatoid
Demyelination
Systemic Inflammatory Response Syndrome
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Carcinoma
Narcolepsy
Osteoarthritis
Mixed Connective Tissue Disease
Infectious disease
Sjogrens Syndrome
Myocarditis
Lymphopenia
Pancreatic Cancer
Cancer Lung
Inflammatory Bowel Diseases
Coronary Artery Disease
Arthritis Psoriatic
Aortic Aneurysm Abdominal
Wasting Syndrome
Heart Diseases
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Insulin Resistance
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Cholangiocarcinoma
OVARIAN CARCINOMA
OBESITY
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STROKE
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TNFRSF1B Gene

Tumor Necrosis Factor Receptor Superfamily, Member 1B

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