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TNFRSF1B Gene

protein-coding   GIFtS: 71
GCID: GC01P012227

Tumor Necrosis Factor Receptor Superfamily, Member 1B


(Previous symbol: TNFR2)
  See TNFRSF1B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 1B1 2     TNF-R752
TNFR21 2 3 5     TNFR1B2
TNFBR2 3 5     TNFR802
Tumor Necrosis Factor Receptor 22 3     P75 TNF Receptor2
Tumor Necrosis Factor Receptor Type II2 3     p75TNFR2
TNF-R22 3     Soluble TNFR1B Variant 12
TNF-RII2 3     Tumor Necrosis Factor Beta Receptor2
p752 3     Tumor Necrosis Factor Binding Protein 22
P80 TNF-Alpha Receptor2 3     Tumor Necrosis Factor Receptor Superfamily Member 1B2
CD120b2     Etanercept3
TBPII2     TNFR-II3
TNF-R-II2     CD120b Antigen3

External Ids:    HGNC: 119171   Entrez Gene: 71332   Ensembl: ENSG000000281377   OMIM: 1911915   UniProtKB: P203333   

Export aliases for TNFRSF1B gene to outside databases

Previous GC identifers: GC01P012291 GC01P012071 GC01P011836 GC01P011936 GC01P012161 GC01P011380


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFRSF1B Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form
a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3
ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought
to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2,
which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting
neurons from apoptosis by stimulating antioxidative pathways. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFRSF1B Gene:
TNFRSF1B (tumor necrosis factor receptor superfamily, member 1B) is a protein-coding gene. Diseases associated with TNFRSF1B include guillain-barre syndrome, and palindromic rheumatism. GO annotations related to this gene include tumor necrosis factor-activated receptor activity and ubiquitin protein ligase binding. An important paralog of this gene is TNFRSF21.

UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333
Function: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for
homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3
to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks
TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological
activity

Gene Wiki entry for TNFRSF1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFRSF1B gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFRSF1B promoter sequence
   Search Chromatin IP Primers for TNFRSF1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

TNFRSF1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF1B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P012227:  view genomic region     (about GC identifiers)

Start:
12,227,060 bp from pter      End:
12,269,285 bp from pter
Size:
42,226 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 1B precursor  
Size: 461 amino acids; 48291 Da
Subunit: Binds to TRAF2. Interacts with BMX
2 PDB 3D structures from and Proteopedia for TNFRSF1B:
1CA9 (3D)        3ALQ (3D)    
Secondary accessions: B1AJZ3 Q16042 Q6YI29 Q9UIH1
Alternative splicing: 2 isoforms:  P20333-1   P20333-2   

Explore the universe of human proteins at neXtProt for TNFRSF1B: NX_P20333

Explore proteomics data for TNFRSF1B at MOPED

Post-translational modifications: 

  • Phosphorylated; mainly on serine residues and with a very low level on threonine residues1
  • A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic
    processing1
  • Glycosylation2 at Asn171, Asn193, Ser208, Ser221, Thr222
  • Modification sites at PhosphoSitePlus

  • See TNFRSF1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001057.1  
    ENSEMBL proteins: 
     ENSP00000365435   ENSP00000440425  

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    Cloud-Clone Corp. Proteins for TNFRSF1B

     
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    Cloud-Clone Corp. ELISAs for TNFRSF1B
    Cloud-Clone Corp. CLIAs for TNFRSF1B
    eBioscience ELISAs for TNFRSF1B: (see all 2
                        Human sTNF-R (80kDa) Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: tumor necrosis factor receptor 2
    Tumour necrosis factor (TNF) receptor family

    2 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR020411 TNFR_1B

    Graphical View of Domain Structure for InterPro Entry P20333

    ProtoNet protein and cluster: P20333

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333
    Similarity: Contains 4 TNFR-Cys repeats


    Find genes that share domains with TNFRSF1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR1B_HUMAN, P20333
    Function: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for
    homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3
    to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks
    TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological
    activity

         Genatlas biochemistry entry for TNFRSF1B:
    tumor necrosis factor receptor superfamily,member 1B,deleted in neuroblastoma,associated with susceptibility to
    systemic lupus erythematosus

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005031tumor necrosis factor-activated receptor activity IEA--
    GO:0005515protein binding IPI10848577
    GO:0031625ubiquitin protein ligase binding IPI11279055
         
    Find genes that share ontologies with TNFRSF1B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TNFRSF1B:
     Decreased Hepatitis C virus re 

         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tnfrsf1b) (see all 19):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system  integument 
     liver/biliary system  mortality/aging  muscle  nervous system  renal/urinary system 

    Find genes that share phenotypes with TNFRSF1B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TNFRSF1B: Tnfrsf1btm1Imx Tnfrsf1btm1Mwm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFRSF1B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF1B

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    Selected qRT-PCR Assays for microRNAs that regulate TNFRSF1B (see all 37):
    hsa-miR-3938 hsa-let-7d hsa-miR-301a hsa-miR-486-3p hsa-let-7g hsa-let-7a hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF1B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF1B

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    GenScript: all cDNA clones in your preferred vector: TNFRSF1B (NM_001066)
    Sino Biological Human cDNA Clone for TNFRSF1B
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNR1B_HUMAN, P20333: Isoform 1: Cell membrane; Single-pass type I membrane protein
    TNR1B_HUMAN, P20333: Isoform 2: Secreted
    TNR1B_HUMAN, P20333: Tumor necrosis factor-binding protein 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    nucleus2
    cytoskeleton1
    cytosol1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TNFRSF1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFRSF1B About   (see all 29)  
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    PGC1Alpha Pathway0.51
    Glucocorticoid Receptor Signaling0.43
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5NF-KappaB Family Pathway
    NF-KappaB (p50-p65) Pathway0.72
    NF-KappaB Family Pathway0.72


    Find genes that share SuperPaths with TNFRSF1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for TNFRSF1B
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF1B (see all 28)
        Caspase Cascade
    MAPK Signaling
    THC Differentiation Pathway
    TRAF Pathway
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for TNFRSF1B
        Apoptosis and Autophagy
    NF-kappaB Signaling

    4 GeneGo (Thomson Reuters) Pathways for TNFRSF1B
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival Apoptotic TNF-family pathways
    Transcription NF-kB signaling pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    Selected BioSystems Pathways for TNFRSF1B (see all 6)
        Apoptosis
    Apoptosis Modulation and Signaling
    TNF-alpha/NF-kB Signaling Pathway
    IL-3 Signaling Pathway
    TNF receptor signaling pathway

    3 Sino Biological Pathways for TNFRSF1B
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    4 Kegg Pathways  (Kegg details for TNFRSF1B):
        Cytokine-cytokine receptor interaction
    TNF signaling pathway
    Adipocytokine signaling pathway
    Amyotrophic lateral sclerosis (ALS)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF1B (see all 12): 
              HIV Host Response in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Multiple Sclerosis in human mouse rat
              Lymphoma in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFRSF1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNFRSF1B (P203331, 2, 3 ENSP000003654354) via UniProtKB, MINT, STRING, and/or I2D (see all 155)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206439P013751, 2, 3EBI-358983,EBI-359977 MINT-48048 MINT-49370 I2D: score=10 
    ENSG00000223952P013751, 2, 3EBI-358983,EBI-359977 MINT-48048 MINT-49370 I2D: score=10 
    ENSG00000230108P013751, 2, 3EBI-358983,EBI-359977 MINT-48048 MINT-49370 I2D: score=10 
    ENSG00000204490P013751, 2, 3, ENSP000003652904EBI-358983,EBI-359977 MINT-48048 MINT-49370 I2D: score=10 STRING: ENSP00000365290
    TNFP013751, 2, 3, ENSP000003986984EBI-358983,EBI-359977 MINT-48048 MINT-49370 I2D: score=10 STRING: ENSP00000398698
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process ----
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007568aging IEA--

    Find genes that share ontologies with TNFRSF1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for TNFRSF1B (TNR1B)

    UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333
    Pharmaceutical: Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe
    rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an
    immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors

    1 DrugBank Compound for TNFRSF1B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    EtanerceptCD120b (see all 7)185243-69-0target--11752352

    2 IUPHAR Ligands for TNFRSF1B (tumor necrosis factor receptor 2)    About this table
    LigandTypeActionAffinityPubmed IDs
    lymphotoxin-alpha
    NoneNone--
    tumour necrosis factor membrane form
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for TNFRSF1B gene (see all 80)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    etanercept 69.4 34 11574988 (1), 12110156 (1), 16796629 (1), 10904249 (1) (see all 29)
    infliximab 54.4 13 19370184 (2), 12110156 (1), 19136378 (1), 12421092 (1) (see all 10)
    tapi 52.1 4 7869036 (2)
    neopterin 48.3 9 9764776 (2), 15642275 (2), 16273760 (1), 10973464 (1) (see all 6)
    gp 130 41.1 7 10575186 (2), 19631179 (1), 19107325 (1), 10414448 (1) (see all 5)
    il 10 29.6 9 12011375 (3), 8891726 (1), 11508666 (1), 19186969 (1)
    fmlp 29.4 8 7998940 (3), 8946217 (1), 9886420 (1)
    endotoxin 27.9 5 1322942 (1), 7622886 (1), 17244513 (1), 9185243 (1) (see all 5)
    rantes 26.8 8 11562425 (2), 11504986 (2), 10843668 (1), 12376864 (1) (see all 6)
    cuprophan 25.7 2 16988495 (1), 11509797 (1)



    Find genes that share compounds with TNFRSF1B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNFRSF1B gene: 
    NM_001066.2  

    Unigene Cluster for TNFRSF1B:

    Tumor necrosis factor receptor superfamily, member 1B
    Hs.256278  [show with all ESTs]
    Unigene Representative Sequence: BC052977
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376259(uc001att.3 uc009vnk.3) ENST00000492361(uc001atu.3)
    ENST00000489921 ENST00000536782
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TNFRSF1B (see all 37):
    hsa-miR-3938 hsa-let-7d hsa-miR-301a hsa-miR-486-3p hsa-let-7g hsa-let-7a hsa-miR-130b hsa-miR-301b
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      QuantiFast Probe-based Assays in human, mouse, rat TNFRSF1B

    Additional mRNA sequence: 

    AY148473.1 BC011844.2 BC042167.1 BC052977.1 BT019927.1 EU826615.1 M32315.1 M35857.1 
    M55994.1 S63368.1 

    7 DOTS entries:

    DT.415651  DT.100823263  DT.100823260  DT.95169202  DT.100823259  DT.100823262  DT.101984571 

    Selected AceView cDNA sequences (see all 183):

    AA533208 AI422018 CA435681 AW170706 AW468069 AA972749 BE466601 H26148 
    AI985195 BC011844 NM_001066 BQ690571 AI360418 CD610466 CD610462 BQ632532 
    BF222736 AI659001 BU158001 AI140025 T78122 AI632561 BE138861 AI762184 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF1B    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                -                                                         
    SP2:                                -                             -     -                     
    SP3:                          -     -                                                         
    SP4:                                                                                          


    ECgene alternative splicing isoforms for TNFRSF1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TNFRSF1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGAGCGCA
    TNFRSF1B Expression
    About this image


    TNFRSF1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
    TNFRSF1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFRSF1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.256278
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF1B (see all 12): 
              HIV Host Response in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Multiple Sclerosis in human mouse rat
              Lymphoma in human mouse rat
              Apoptosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF1B gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf1b1 , 5 tumor necrosis factor receptor superfamily, member more1, 5 74.25(n)1
    64.11(a)1
      4 (78.17 cM)5
    219381  NM_011610.31  NP_035740.21 
     1452134635 
    chicken
    (Gallus gallus)
    Aves TNFRSF1B1 tumor necrosis factor receptor superfamily, member more 45.34(n)
    35.78(a)
      395083  NM_204439.3  NP_989770.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tnfrsf1b6
    tumor necrosis factor receptor superfamily, member...
    26(a)
    1 ↔ 1
    11(41910114-41933153) ENSDARG00000070165


    ENSEMBL Gene Tree for TNFRSF1B (if available)
    TreeFam Gene Tree for TNFRSF1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNFRSF1B gene
    TNFRSF212  TNFRSF11A2  TNFRSF6B2  LTBR2  TNFRSF11B2  TNFRSF142  CD402  
    3 SIMAP similar genes for TNFRSF1B using alignment to 2 protein entries:     TNR1B_HUMAN (see all proteins):
    TNFR1B    CD40    TNFRSF6B

    Find genes that share paralogs with TNFRSF1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFRSF1B (see all 1124)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017347881,2
    C--11396922(+) TATCT-/ATC   
       TGTTT
    GTCTG
    1 -- int10--------
    rs1499047991,2
    --11396963(+) TTATC-/TATTT 
            
    TATCT
    1 -- int10--------
    rs32167951,2
    C,F--11401495(+) TCACATG/-AGTGT 1 -- int14Minor allele frequency- -:0.09NS CSA 244
    rs1138565031,2
    C--11410251(+) TTTTTT/-CTTTC 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs57460561,2
    C,F--11415953(+) CTACTG/AATAAT 1 -- int18Minor allele frequency- A:0.15NS NA WA EA 630
    rs57460571,2
    C,F,H--11415954(+) TACTGA/CTAATT 1 -- int19Minor allele frequency- C:0.18NS EA NA 664
    rs178825801,2
    C,F--12229032(+) TCCCCC/-GCCTC 1 -- int12Minor allele frequency- -:0.11NS 88
    rs178791531,2
    C,F--12230234(+) CATTCATTC/-  
            
    CCCAA
    1 -- int12Minor allele frequency- -:0.22NS 94
    rs617748881,2
    F--12234229(+) CTTCTC/TCTTCT 1 -- int11Minor allele frequency- T:0.50NA 2
    rs617748891,2
    F--12234235(+) CTTCTC/TCTTCT 1 -- int11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for TNFRSF1B (12227060 - 12269285 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for TNFRSF1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508891CNV Insertion20534489
    nsv871537CNV Loss21882294
    nsv527024CNV Loss19592680
    nsv871714CNV Loss21882294
    dgv144n71CNV Loss21882294
    dgv143n71CNV Gain21882294
    nsv871005CNV Gain21882294
    nsv870819CNV Gain21882294
    nsv471622CNV Gain+Loss15918152
    nsv469830CNV Complex16826518

    Human Gene Mutation Database (HGMD): TNFRSF1B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFRSF1B
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFRSF1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 191191    OMIM disorders: --

    13 diseases for TNFRSF1B:    
    About MalaCards
    guillain-barre syndrome    palindromic rheumatism    post-transplant lymphoproliferative disease    pneumococcal meningitis
    connective tissue disease    exanthem    mixed connective tissue disease    spondylitis
    narcolepsy    behcet's disease    rheumatoid arthritis    schizophrenia
    malaria

    18 diseases from the University of Copenhagen DISEASES database for TNFRSF1B:
    Rheumatoid arthritis     Psoriasis     Psoriatic arthritis     Ankylosing spondylitis
    Crohn's disease     Tuberculosis     Hypersensitivity reaction type II disease     Vasculitis
    Uveitis     Arthropathy     Dermatitis     Synovitis
    Exanthem     Hidradenitis suppurativa     Sarcoidosis     adult-onset Still's disease
    Pneumonia     Myositis

    Find genes that share disorders with TNFRSF1B           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TNFRSF1B gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 88.9 718 7573266 (5), 10561634 (4), 1324217 (3), 1655619 (2) (see all 99)
    tumors 76.6 638 7573266 (5), 9669810 (4), 10561634 (4), 9677439 (3) (see all 99)
    rheumatoid arthritis 63.4 46 9290265 (3), 10765919 (2), 15022314 (2), 15603867 (2) (see all 30)
    inflammation 48.6 18 19343543 (1), 18848768 (1), 11156356 (1), 16947419 (1) (see all 16)
    arthritis psoriatic 45 6 17502870 (1), 19222252 (1), 17394851 (1), 12011375 (1)
    spondylitis ankylosing 43.4 4 19177266 (1), 11986408 (1), 17502870 (1), 17394851 (1)
    fibroma shope 43.3 1 8590321 (1)
    lupus erythematosus systemic 35.6 35 12739039 (3), 11762942 (2), 15642275 (2), 11197692 (2) (see all 18)
    autoimmune diseases 32.2 7 11169260 (4), 17785864 (1), 20225650 (1), 10436260 (1)
    shock septic 31 4 8627066 (1), 11084543 (1), 11253333 (1), 15526005 (1)

    Genetic Association Database (GAD): TNFRSF1B
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF1B (154 documents)

    Export disorders for TNFRSF1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFRSF1B gene, integrated from 10 sources (see all 863):
    (articles sorted by number of sources associating them with TNFRSF1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism. (PubMed id 12161545)1, 2, 4, 9 Peral B....Escobar-Morreale H.F. (J. Clin. Endocrinol. Metab. 2002)
    2. Association of tumor necrosis factor receptor type II polymorphism 196R with systemic lupus erythematosus in the Japanese: molecular and functional analysis. (PubMed id 11762942)1, 2, 4, 9 Morita C.... Niho Y. (Arthritis Rheum. 2001)
    3. New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus. (PubMed id 11197692)1, 2, 4, 9 Tsuchiya N.... Tokunaga K. (Genes Immun. 2000)
    4. Bone structural effects of variation in the TNFRSF1B gene encoding the tumor necrosis factor receptor 2. (PubMed id 18038243)1, 4, 9 Mullin B.H....Wilson S.G. (Osteoporos Int 2008)
    5. The biallelic variable number of tandem repeats of the tumor necrosis factor receptor 2 promoter in systemic lupus erythematosus. (PubMed id 12739039)1, 4, 9 Lee Y.H....Song G.G. (Rheumatol. Int. 2003)
    6. Tumor necrosis factor receptor 2 gene (TNFRSF1B) in genetic basis of coronary artery disease. (PubMed id 11357933)1, 4, 9 Benjafield A.V....Morris B.J. (J. Mol. Med. 2001)
    7. A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: a case-control study and a meta-analysis. (PubMed id 17028114)1, 4, 9 Horiuchi T....Harada M. (Ann. Rheum. Dis. 2007)
    8. Association between TNFRSF1B polymorphisms and bone mineral density, bone loss and fracture. (PubMed id 15071724)1, 4, 9 Tasker P.N....Ralston S.H. (Osteoporos Int 2004)
    9. Single nucleotide polymorphisms in TNF-alpha, TNFR2 gene and TNF-alpha production in Asian Indians. (PubMed id 19811435)1, 4, 9 Gupta R....Das S.N. (Immunol. Invest. 2009)
    10. Polymorphisms of the tumor necrosis factor-alpha receptor 2 gene are associated with obesity phenotypes among 405 Caucasian nuclear families. (PubMed id 18685868)1, 4, 9 Zhao L.J....Deng H.W. (Hum. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7133 HGNC: 11917 AceView: TNFRSF1B Ensembl:ENSG00000028137 euGenes: HUgn7133
    ECgene: TNFRSF1B Kegg: 7133 H-InvDB: TNFRSF1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNFRSF1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF1B Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/tnfrsf1b/
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf1b/
    Enbrelhttp://www.enbrel.com/index.jspx

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFRSF1B gene:
    Search GeneIP for patents involving TNFRSF1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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