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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TNFRSF1B Gene

protein-coding GIFtS: 71
GCID: GC01P012161

tumor necrosis factor receptor superfamily, member 1B

(Previous symbol: TNFR2)

Explore 197 diseases affiliated with
TNFRSF1B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 1B¹ ²		P80 TNF-Alpha Receptor² ³
TNFBR¹ ² ³ ⁵		TBPII²
TNFR2¹ ² ³ ⁵		TNFR1B²
P75¹		P75 TNF Receptor²
CD120b¹ ²		P75TNFR¹
TNF-R-II¹ ²		Soluble TNFR1B Variant 1²
TNF-R75¹ ²		Tumor Necrosis Factor Beta Receptor²
TNFR80¹ ²		Tumor Necrosis Factor Binding Protein 2²
Tumor Necrosis Factor Receptor 2² ³		Tumor Necrosis Factor Receptor Superfamily Member 1B²
Tumor Necrosis Factor Receptor Type II² ³		Etanercept³
TNF-R2² ³		TNFR-II³
TNF-RII² ³		CD120b Antigen³

External Ids:	HGNC: 11917¹	Entrez Gene: 7133²	Ensembl: ENSG00000028137⁷	OMIM: 191191⁵	UniProtKB: P20333³

Export aliases for TNFRSF1B gene to outside databases

Previous GC identifers: GC01P012291 GC01P012071 GC01P011836 GC01P011936 GC01P011380

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF1B:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a

heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3

ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to

potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which

mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons

from apoptosis by stimulating antioxidative pathways. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333

Function: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric

TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to

TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced

apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity

Gene Wiki entry for TNFRSF1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_021937.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNFRSF1B gene promoter:
AML1a STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNFRSF1B promoter sequence

Search SABiosciences Chromatin IP Primers for TNFRSF1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.22

TNFRSF1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF1B gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P012161: view genomic region (about GC identifiers)

Start:	12,227,060 bp from pter	End:	12,269,285 bp from pter
Size:	42,226 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 1B precursor

Size: 461 amino acids; 48291 Da

Subunit: Binds to TRAF2. Interacts with BMX

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

Subcellular location: Tumor necrosis factor-binding protein 2: Secreted

2 PDB 3D structures from and Proteopedia for TNFRSF1B:

1CA9 (3D)

3ALQ (3D)

Secondary accessions: B1AJZ3 Q16042 Q6YI29 Q9UIH1

Alternative splicing: 2 isoforms: P20333-1 P20333-2

Explore the universe of human proteins at neXtProt for TNFRSF1B: NX_P20333

Post-translational modifications:

Phosphorylated; mainly on serine residues and with a very low level on threonine residues¹

A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20333

TNFRSF1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001057.1

ENSEMBL proteins:

ENSP00000365435 ENSP00000440425

Human Recombinant Protein Products for TNFRSF1B:

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	Sino Biological Recombinant Protein for TNFRSF1B
	ProSpec Recombinant Protein for TNFRSF1B
	Uscn Proteins for TNFRSF1B

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--

TNFRSF1B for ontologies About GeneDecksing

TNFRSF1B Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TNFRSF1B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNFRSF1B for domains About GeneDecksing

2 InterPro domains/families:

IPR001368 TNFR/NGFR_Cys_rich_reg

IPR020411 TNFR_1B

Graphical View of Domain Structure for InterPro Entry P20333

ProtoNet protein and cluster: P20333

1 Blocks protein family: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333

Similarity: Contains 4 TNFR-Cys repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TNR1B_HUMAN, P20333

Function: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric

TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to

TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced

apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity

Genatlas biochemistry entry for TNFRSF1B:

tumor necrosis factor receptor superfamily,member 1B,deleted in neuroblastoma,associated with susceptibility to

systemic lupus erythematosus

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005031	tumor necrosis factor-activated receptor activity	IEA	--
GO:0005515	protein binding	IPI	10848577
GO:0031625	ubiquitin protein ligase binding	IPI	11279055

TNFRSF1B for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for TNFRSF1B:

Decreased Hepatitis C virus re

15/19 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tnfrsf1b) (see all 19):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	immune system	integument
liver/biliary system	mortality/aging	muscle	nervous system	renal/urinary system

TNFRSF1B for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for TNFRSF1B: Tnfrsf1b^tm1Imx Tnfrsf1b^tm1Mwm

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TNFRSF1B

miRNA Products:		OriGene 3'-UTR Clone: TNFRSF1B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFRSF1B
		8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFRSF1B (see all 37):
		hsa-miR-3938 hsa-let-7d hsa-miR-301a hsa-miR-486-3p hsa-let-7g hsa-let-7a hsa-miR-130b hsa-miR-301b

		SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF1B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFRSF1B (see all 7) OriGene shRNA RFP: TNFRSF1B OriGene siRNA: TNFRSF1B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFRSF1B
		Sirion Biotech Custom design and validation of potent shRNA sequences against TNFRSF1B

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TNFRSF1B
			Sirion Biotech Customized adenovirus for overexpression of TNFRSF1B Sirion Biotech Customized adenovirus for potent knockdown of TNFRSF1B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF1B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF1B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TNFRSF1B (NM_001066)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TNFRSF1B
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF1B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway	1.00			Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway	0.46
	Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway	1.00			Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway	0.46

TGF-Beta Pathway

	TGF-Beta Pathway	1.00			JAK-STAT Pathway	0.57
	MAPK Family Pathway	0.60			JNK Pathway	0.50

PEDF Induced Signaling

	STAT3 Pathway	0.47			Glucocorticoid Receptor Signaling	0.27
	PGC1Alpha Pathway	0.33			Cytokine-cytokine receptor interaction	0.26

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

TRAF Pathway

	TRAF Pathway	1.00			TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions	0.08
	TNF Superfamily Pathway	0.42

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for TNFRSF1B

	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
	Apoptosis and survival Apoptotic TNF-family pathways
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

3 R&D Systems Pathways for TNFRSF1B

	TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF1B (see all 28)

	Caspase Cascade
	MAPK Signaling
	THC Differentiation Pathway
	TRAF Pathway
	Molecular Mechanisms of Cancer

2 Cell Signaling Technology (CST) Pathways for TNFRSF1B

	Apoptosis and Autophagy
	NF-kappaB Signaling

4 GeneGo (Thomson Reuters) Pathways for TNFRSF1B

	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
	Apoptosis and survival Apoptotic TNF-family pathways
	Transcription NF-kB signaling pathway
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

5/6 BioSystems Pathways for TNFRSF1B (see all 6)

	Apoptosis Modulation and Signaling
	Apoptosis
	IL-3 Signaling Pathway
	TNF-alpha/NF-kB Signaling Pathway
	TNF receptor signaling pathway

3 Kegg Pathways (Kegg details for TNFRSF1B):

	Cytokine-cytokine receptor interaction
	Adipocytokine signaling pathway
	Amyotrophic lateral sclerosis (ALS)

TNFRSF1B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TNFRSF1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/135 Interacting proteins for TNFRSF1B (P20333^{2, 3} ENSP00000365435⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 135)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALM2	P62158²^,³	MINT-49428 I2D: score=2
CALM3	P62158²^,³	MINT-49428 I2D: score=2
FANCD2	Q9BXW9²^,³	MINT-49427 MINT-48047 I2D: score=4
AIFM1	O95831²^,³, ENSP00000287295⁴	MINT-49368 I2D: score=2 STRING: ENSP00000287295
C1QBP	Q07021²^,³, ENSP00000225698⁴	MINT-49395 I2D: score=2 STRING: ENSP00000225698

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	IEA	--
GO:0007166	cell surface receptor signaling pathway	--	--
GO:0008219	cell death	--	--

TNFRSF1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TNFRSF1B for compounds About GeneDecksing

EMD Millipore small molecules for TNFRSF1B:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNFRSF1B
UniProtKB/Swiss-Prot: TNR1B_HUMAN, P20333

Pharmaceutical: Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid

arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc

chain. It binds to TNF-alpha and blocks its interactions with receptors

1 DrugBank Compound for TNFRSF1B About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Etanercept	CD120b (see all 7)	185243-69-0	target	--	11752352

10/80 Novoseek chemical compound relationships for TNFRSF1B gene (see all 80) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
etanercept	69.4	34	11574988 (1), 12110156 (1), 16796629 (1), 10904249 (1) (see all 29)
infliximab	54.4	13	19370184 (2), 12110156 (1), 19136378 (1), 12421092 (1) (see all 10)
tapi	52.1	4	7869036 (2)
neopterin	48.3	9	9764776 (2), 15642275 (2), 16273760 (1), 10973464 (1) (see all 6)
gp 130	41.1	7	10575186 (2), 19631179 (1), 19107325 (1), 10414448 (1) (see all 5)
il 10	29.6	9	12011375 (3), 8891726 (1), 11508666 (1), 19186969 (1)
fmlp	29.4	8	7998940 (3), 8946217 (1), 9886420 (1)
endotoxin	27.9	5	1322942 (1), 7622886 (1), 17244513 (1), 9185243 (1) (see all 5)
rantes	26.8	8	11562425 (2), 11504986 (2), 10843668 (1), 12376864 (1) (see all 6)
cuprophan	25.7	2	16988495 (1), 11509797 (1)

Search CenterWatch for drugs/clinical trials and news about TNFRSF1B / TNR1B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNFRSF1B gene:

NM_001066.2

Unigene Cluster for TNFRSF1B:

Tumor necrosis factor receptor superfamily, member 1B

Hs.256278 [show with all ESTs]

Unigene Representative Sequence: BC052977

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000376259(uc001att.3 uc009vnk.3) ENST00000492361(uc001atu.3)

ENST00000489921 ENST00000536782

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		8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFRSF1B (see all 37):
		hsa-miR-3938 hsa-let-7d hsa-miR-301a hsa-miR-486-3p hsa-let-7g hsa-let-7a hsa-miR-130b hsa-miR-301b

		SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF1B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against TNFRSF1B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF1B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF1B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TNFRSF1B (NM_001066)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF1B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF1B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFRSF1B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TNFRSF1B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF1B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF1B

Additional cDNA sequence:

AY148473.1 BC011844.2 BC042167.1 BC052977.1 BT019927.1 EU826615.1 M32315.1 M35857.1

M55994.1 S63368.1

7 DOTS entries:

DT.415651 DT.100823263 DT.100823260 DT.95169202 DT.100823259 DT.100823262 DT.101984571

24/183 AceView cDNA sequences (see all 183):

AA470868 F01858 BE138861 AI307670 AJ346375 AA972749 BU899219 CB069666

AI762184 BU158001 AA533208 AI247670 CA435681 BM993941 AI422018 T78122

CD610462 BC042167 BM129147 AW170706 S63368 AW468069 AI659001 NM_001066

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF1B About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b
SP1:											-
SP2:											-										-		-
SP3:									-		-
SP4:

ECgene alternative splicing isoforms for TNFRSF1B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNFRSF1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGAGCGCA

About this image

TNFRSF1B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 9 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

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PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

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PureStem™ progenitor W10 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Syncytiotrophoblast-like cells (Generation of syncyt...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TNFRSF1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFRSF1B

SOURCE GeneReport for Unigene cluster: Hs.256278

SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF1B (see all 12):

HIV Host Response in human mouse rat

NFKB Signaling Targets in human mouse rat

Multiple Sclerosis in human mouse rat

Lymphoma in human mouse rat

Apoptosis in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF1B gene from 2/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TNFRSF1B¹	tumor necrosis factor receptor superfamily, member more	48.02(n) 38.37(a)		395083 NM_204439.2 NP_989770.2
zebrafish (Danio rerio)	Actinopterygii	zgc:163064¹	zgc:163064	41.4(n) 31.84(a)		100037357 NM_001089510.1 NP_001082979.1

ENSEMBL Gene Tree for TNFRSF1B (if available)
TreeFam Gene Tree for TNFRSF1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TNFRSF1B gene

TNFRSF21² TNFRSF6B² CD40² TNFRSF4² TNFRSF11A² TNFRSF9² NGFR² TNFRSF14²

TNFRSF11B² LTBR²

3 SIMAP similar genes for TNFRSF1B using alignment to 2 protein entries: TNR1B_HUMAN (see all proteins):

TNFR1B CD40 TNFRSF6B

TNFRSF1B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5745937^1,2	C,F,H	--	11378594(+)	`CAGTCT/CGTTGG`	1	--	us2k¹		6	NS EA	510
rs652625^1,2	C,F,A,H	--	11378600(-)	`ATGGGA/TCCAAC`	1	--	us2k¹		37	EA NA NS WA CSA	3630
rs5745938^1,2	C,F	--	11378623(+)	`GTGTGG/TGGGAC`	1	--	us2k¹		5	NS NA	360
rs652599^1,2	C,F	--	11378624(-)	`TGTCCC/TCCACA`	1	--	us2k¹		24	EA NA NS WA CSA	2748
rs5745940^1,2	C,F	--	11379169(+)	`CTGGCA/CCTCAA`	1	--	us2k¹ tfbs³		6	NS NA WA	368
rs5745941^1,2	C	--	11379183(+)	`GGGGAT/CGGGGG`	1	--	us2k¹		1	NS	156
rs5745942^1,2	C,F	--	11379218(+)	`CTCGGT/CCATGA`	1	--	us2k¹		5	NS WA CSA	280
rs11807973^1,2	C,F,H	--	11379222(+)	`GTCATG/TATGTA`	1	--	us2k¹ tfbs³		11	NS NA WA	870
rs56386304^1,2	C	--	11379472(+)	`GTAGAC/TACTTA`	1	--	us2k¹		1	WA	2
rs3753576^1,2	C,F,H	--	11379519(-)	`AGATAT/CGTAAT`	1	--	us2k¹		4	EA NS NA	609

HapMap Linkage Disequilibrium report for TNFRSF1B (12227060 - 12269285 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TNFRSF1B
1 CNV: 0676
Human Gene Mutation Database (HGMD): TNFRSF1B

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TNFRSF1B for disorders           About GeneDecksing

OMIM gene information: 191191    OMIM disorders: --

20/197 diseases for TNFRSF1B (see all 197):    About MalaCards

post-transplant lymphoproliferative disease guillain-barre syndrome mixed connective tissue disease adult-onset still's disease

relapsing-remitting multiple sclerosis connective tissue disease hypersensitivity reaction type ii disease amyotrophic lateral sclerosis (als)

hidradenitis suppurativa patent ductus arteriosus microscopic polyangiitis graft versus host disease

amyotrophic lateral sclerosis lichen planus palindromic rheumatism common variable immunodeficiency

oral lichen planus pre-eclampsia nonalcoholic steatohepatitis systemic lupus erythematosus

16 diseases from the University of Copenhagen DISEASES database for TNFRSF1B (see first 20):

Rheumatoid arthritis Psoriasis Psoriatic arthritis Ankylosing spondylitis

Crohn's disease Tuberculosis Hypersensitivity reaction type II disease Vasculitis

Arthropathy Uveitis Dermatitis Synovitis

Hidradenitis suppurativa Sarcoidosis adult-onset Still's disease Pneumonia

10/93 Novoseek disease relationships for TNFRSF1B gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	88.9	718	7573266 (5), 10561634 (4), 1324217 (3), 1655619 (2) (see all 99)
tumors	76.6	638	7573266 (5), 9669810 (4), 10561634 (4), 9677439 (3) (see all 99)
rheumatoid arthritis	63.4	46	9290265 (3), 10765919 (2), 15022314 (2), 15603867 (2) (see all 30)
inflammation	48.6	18	19343543 (1), 18848768 (1), 11156356 (1), 16947419 (1) (see all 16)
arthritis psoriatic	45	6	17502870 (1), 19222252 (1), 17394851 (1), 12011375 (1)
spondylitis ankylosing	43.4	4	19177266 (1), 11986408 (1), 17502870 (1), 17394851 (1)
fibroma shope	43.3	1	8590321 (1)
lupus erythematosus systemic	35.6	35	12739039 (3), 11762942 (2), 15642275 (2), 11197692 (2) (see all 18)
autoimmune diseases	32.2	7	11169260 (4), 17785864 (1), 20225650 (1), 10436260 (1)
shock septic	31	4	8627066 (1), 11084543 (1), 11253333 (1), 15526005 (1)

Genetic Association Database (GAD): TNFRSF1B
Human Genome Epidemiology (HuGE) Navigator: TNFRSF1B (154 documents)

Export disorders for TNFRSF1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TNFRSF1B gene, integrated from 9 sources (see all 838):
(articles sorted by number of sources associating them with TNFRSF1B)

Utopia: connect your pdf to the dynamic
world of online information

Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism. (PubMed id 12161545)^{1, 2, 4, 9} Peral B....Escobar-Morreale H.F. (2002)
Association of tumor necrosis factor receptor type II polymorphism 196R with systemic lupus erythematosus in the Japanese: molecular and functional analysis. (PubMed id 11762942)^{1, 2, 4, 9} Morita C.... Niho Y. (2001)
New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus. (PubMed id 11197692)^{1, 2, 4, 9} Tsuchiya N.... Tokunaga K. (2000)
The biallelic variable number of tandem repeats of the tumor necrosis factor receptor 2 promoter in systemic lupus erythematosus. (PubMed id 12739039)^{1, 4, 9} Lee Y.H....Song G.G. (2003)
Association between TNFRSF1B polymorphisms and bone mineral density, bone loss and fracture. (PubMed id 15071724)^{1, 4, 9} Tasker P.N....Ralston S.H. (2004)
No association with hypertension of CLCNKB and TNFRSF1B polymorphisms at a hypertension locus on chromosome 1p36. (PubMed id 16003175)^{1, 4, 9} Speirs H.J....Morris B.J. (2005)
A functional polymorphism of the tumor necrosis factor receptor-II gene associated with the survival and relapse prediction of breast carcinoma. (PubMed id 15863392)^{1, 4, 9} Mestiri S....Chouchane L. (2005)
Association of polymorphisms of the tumour necrosis factor receptors I and II and rheumatoid arthritis. (PubMed id 12730509)^{1, 4, 9} Bayley J.P....Verweij C.L. (2003)
-238 and +489 TNF-alpha along with TNF-RII gene polymorphisms associate with the diffuse phenotype in patients with Systemic Sclerosis. (PubMed id 15585313)^{1, 4, 9} Tolusso B....Ferraccioli G. (2005)
Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis. (PubMed id 16277675)^{1, 4, 9} Glossop J.R....Mattey D.L. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7133	HGNC: 11917	AceView: TNFRSF1B	Ensembl:ENSG00000028137	euGenes: HUgn7133
ECgene: TNFRSF1B	Kegg: 7133	H-InvDB: TNFRSF1B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TNFRSF1B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFRSF1B	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/tnfrsf1b/
NIEHS-SNPs	http://egp.gs.washington.edu/data/tnfrsf1b/
Enbrel	http://www.enbrel.com/index.jspx

Intellectual Property for TNFRSF1B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TNFRSF1B gene:
Search GeneIP for patents involving TNFRSF1B

GeneCards and IP:
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TNFRSF1B Gene

tumor necrosis factor receptor superfamily, member 1B

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TNFRSF1B (Gene Symbol)
Tumor Necrosis Factor Receptor Superfamily, Member 1B
TNFBR
TNFR2
P75
CD120b
TNF-R-II
TNF-R75
TNFR80
Tumor Necrosis Factor Receptor 2
Tumor Necrosis Factor Receptor Type II
TNF-R2
TNF-RII
P80 TNF-Alpha Receptor
TBPII
TNFR1B
P75 TNF Receptor
P75TNFR
Soluble TNFR1B Variant 1
Tumor Necrosis Factor Beta Receptor
Tumor Necrosis Factor Binding Protein 2
Tumor Necrosis Factor Receptor Superfamily Member 1B
Etanercept
TNFR-II
CD120b Antigen

Spondylitis Ankylosing
Dementia
Genetic Susceptibility
Parasitemia
Retinoblastoma
sepsis
essential hypertension
Endometriosis
Herpes Simplex
NEUROPATHY, PAINFUL
Colitis Ulcerative
Fibroma Shope
ADENOCARCINOMA LUNG
insulin sensitivity
Breast Cancer
Edema
primary tumor
Rheumatic Diseases
Schizophrenia
cell damage
Cancer
Lymphoma
Guillain-Barre Syndrome
effusion
Osteolysis
Colorectal Cancer
Multiple Sclerosis
Inflammation
Tuberculosis
Neutropenia
Hyperglycemia
Psoriasis
Anemia
MYELOMA
Renal Failure
Sarcoidosis
Rheumatoid Arthritis
Pneumonia
Tumors
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Fibrosarcoma
Sarcoma
Glioblastoma
Preeclampsia
Shock Septic
Colitis
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Encephalomyelitis
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BREAST CARCINOMA
Neurological Disorders
Vasculitis
Hyperplasia
Arthritis Juvenile Rheumatoid
Demyelination
Systemic Inflammatory Response Syndrome
Hodgkin Disease
Carcinoma
Narcolepsy
Osteoarthritis
Mixed Connective Tissue Disease
Infectious disease
Sjogrens Syndrome
Myocarditis
Lymphopenia
Pancreatic Cancer
Cancer Lung
Inflammatory Bowel Diseases
Coronary Artery Disease
Arthritis Psoriatic
Aortic Aneurysm Abdominal
Wasting Syndrome
Heart Diseases
HIV Infections
Insulin Resistance
BEHCET DISEASE
Cholangiocarcinoma
OVARIAN CARCINOMA
OBESITY
solid tumor
Carcinoma Squamous Cell
SKIN LESION
Hepatitis C Chronic
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STROKE
Lupus Nephritis
Lymphoma Non-Hodgkins
Synovitis
Polymyositis
Arthritis
Lupus Erythematosus Systemic

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TNFRSF1B Gene

tumor necrosis factor receptor superfamily, member 1B

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