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Aliases for TNFRSF1B Gene

Aliases for TNFRSF1B Gene

  • TNF Receptor Superfamily Member 1B 2 3 5
  • Tumor Necrosis Factor Receptor Type II 3 4
  • Tumor Necrosis Factor Receptor 2 3 4
  • P80 TNF-Alpha Receptor 3 4
  • TNF-RII 3 4
  • TNF-R2 3 4
  • TNFBR 3 4
  • TNFR2 3 4
  • P75 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 1B 2
  • Tumor Necrosis Factor Receptor Superfamily Member 1B 3
  • Tumor Necrosis Factor Binding Protein 2 3
  • Tumor Necrosis Factor Beta Receptor 3
  • Soluble TNFR1B Variant 1 3
  • P75 TNF Receptor 3
  • CD120b Antigen 4
  • Etanercept 4
  • TNF-R-II 3
  • TNFR-II 4
  • TNF-R75 3
  • P75TNFR 3
  • CD120b 3
  • TNFR1B 3
  • TNFR80 3
  • TBPII 3

External Ids for TNFRSF1B Gene

Previous HGNC Symbols for TNFRSF1B Gene

  • TNFR2

Previous GeneCards Identifiers for TNFRSF1B Gene

  • GC01P012291
  • GC01P012071
  • GC01P011836
  • GC01P011936
  • GC01P012161
  • GC01P011380
  • GC01P012227

Summaries for TNFRSF1B Gene

Entrez Gene Summary for TNFRSF1B Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF1B Gene

TNFRSF1B (TNF Receptor Superfamily Member 1B) is a Protein Coding gene. Diseases associated with TNFRSF1B include Mycosis Fungoides and Sezary's Disease. Among its related pathways are TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions and mTOR signaling pathway (KEGG). GO annotations related to this gene include ubiquitin protein ligase binding and tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF21.

UniProtKB/Swiss-Prot for TNFRSF1B Gene

  • Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Gene Wiki entry for TNFRSF1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF1B Gene

Genomics for TNFRSF1B Gene

Regulatory Elements for TNFRSF1B Gene

Enhancers for TNFRSF1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F012156 1.6 FANTOM5 ENCODE 35.6 -6.3 -6319 7.3 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 FEZF1 YY1 ZNF766 CBX5 TNFRSF1B UBIAD1 MTHFR TNFRSF8 CLCN6 AGTRAP FBXO6 MFN2 MIR7846 RPL23AP89
GH01F012140 1.8 FANTOM5 Ensembl ENCODE 24 -19.2 -19192 15.3 HDGF PKNOX1 ARNT SIN3A ZNF2 YY1 ZNF143 ZNF207 FOS REST TNFRSF1B UBIAD1 MTHFR TNFRSF8 CLCN6 AGTRAP NPPA-AS1 FBXO6 MFN2 MIR7846
GH01F012166 1.8 FANTOM5 Ensembl ENCODE 21.2 +10.3 10277 21.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A YY1 ZNF143 ZNF207 FOS MTHFR TNFRSF1B UBIAD1 TNFRSF8 CLCN6 VPS13D DHRS3 AGTRAP MIIP MFN2
GH01F011978 1.8 FANTOM5 Ensembl ENCODE 16.9 -184.2 -184212 8.6 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 ZNF143 MCM3 SP3 NFYC MFN2 MIIP TNFRSF1B PLOD1 KIAA2013 RNU5E-1 RNU5E-4P DHRS3 EXOSC10 NPPB
GH01F011735 1.5 FANTOM5 ENCODE 14.6 -430.1 -430057 3.4 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 AGTRAP TNFRSF1B MAD2L2 DRAXIN EXOSC10 C1orf127 MTHFR CLCN6 TNFRSF8 FBXO6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFRSF1B on UCSC Golden Path with GeneCards custom track

Promoters for TNFRSF1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001517457 857 2401 PKNOX1 CREB3L1 WRNIP1 YY1 GATA2 ZNF143 ZNF207 KLF13 ZNF263 JUNB

Transcription factor binding sites by QIAGEN in the TNFRSF1B gene promoter:

Genomic Location for TNFRSF1B Gene

Chromosome:
1
Start:
12,166,943 bp from pter
End:
12,209,228 bp from pter
Size:
42,286 bases
Orientation:
Plus strand

Genomic View for TNFRSF1B Gene

Genes around TNFRSF1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF1B Gene

Proteins for TNFRSF1B Gene

  • Protein details for TNFRSF1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20333-TNR1B_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 1B
    Protein Accession:
    P20333
    Secondary Accessions:
    • B1AJZ3
    • Q16042
    • Q6YI29
    • Q9UIH1

    Protein attributes for TNFRSF1B Gene

    Size:
    461 amino acids
    Molecular mass:
    48291 Da
    Quaternary structure:
    • Binds to TRAF2. Interacts with BMX.
    • Binds to TRAF2. Interacts with BMX.

    Three dimensional structures from OCA and Proteopedia for TNFRSF1B Gene

    Alternative splice isoforms for TNFRSF1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFRSF1B Gene

Post-translational modifications for TNFRSF1B Gene

  • A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
  • Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
  • Glycosylation at Thr 30, Asn 171, Asn 193, Thr 206, Ser 221, and Thr 222
  • Modification sites at PhosphoSitePlus

Protein Products

  • Enzo Life Sciences proteins for TNFRSF1B
  • Cloud-Clone Corp. Proteins for TNFRSF1B

No data available for DME Specific Peptides for TNFRSF1B Gene

Domains & Families for TNFRSF1B Gene

Protein Domains for TNFRSF1B Gene

Graphical View of Domain Structure for InterPro Entry

P20333

UniProtKB/Swiss-Prot:

TNR1B_HUMAN :
  • Contains 4 TNFR-Cys repeats.
Similarity:
  • Contains 4 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF1B: view

Function for TNFRSF1B Gene

Molecular function for TNFRSF1B Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 1B,deleted in neuroblastoma,associated with susceptibility to systemic lupus erythematosus
UniProtKB/Swiss-Prot Function:
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Gene Ontology (GO) - Molecular Function for TNFRSF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005031 tumor necrosis factor-activated receptor activity IEA --
GO:0005515 protein binding IPI 8069916
GO:0031625 ubiquitin protein ligase binding IPI 11279055
genes like me logo Genes that share ontologies with TNFRSF1B: view
genes like me logo Genes that share phenotypes with TNFRSF1B: view

Animal Models for TNFRSF1B Gene

MGI Knock Outs for TNFRSF1B:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for TNFRSF1B (TNF RII/TNFRSF1B)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF1B Gene

Localization for TNFRSF1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF1B Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Tumor necrosis factor-binding protein 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF1B gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 3
cytosol 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TNFRSF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF1B: view

Pathways & Interactions for TNFRSF1B Gene

genes like me logo Genes that share pathways with TNFRSF1B: view

SIGNOR curated interactions for TNFRSF1B Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TNFRSF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with TNFRSF1B: view

Drugs & Compounds for TNFRSF1B Gene

(45) Drugs for TNFRSF1B Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Etanercept Approved, Investigational Pharma Target 397
Infliximab Approved Pharma 378
tumour necrosis factor membrane form Pharma 0
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
CYT-6091 Pharma 0

(40) Additional Compounds for TNFRSF1B Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
lymphotoxin-alpha
genes like me logo Genes that share compounds with TNFRSF1B: view

Transcripts for TNFRSF1B Gene

Unigene Clusters for TNFRSF1B Gene

Tumor necrosis factor receptor superfamily, member 1B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for TNFRSF1B (TNF RII/TNFRSF1B)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF1B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for TNFRSF1B Gene

GeneLoc Exon Structure for
TNFRSF1B
ECgene alternative splicing isoforms for
TNFRSF1B

Expression for TNFRSF1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFRSF1B Gene

mRNA differential expression in normal tissues according to GTEx for TNFRSF1B Gene

This gene is overexpressed in Whole Blood (x24.5).

Protein differential expression in normal tissues from HIPED for TNFRSF1B Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF1B Gene



Protein tissue co-expression partners for TNFRSF1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF1B Gene:

TNFRSF1B

SOURCE GeneReport for Unigene cluster for TNFRSF1B Gene:

Hs.256278
genes like me logo Genes that share expression patterns with TNFRSF1B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TNFRSF1B Gene

Orthologs for TNFRSF1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF1B 34 35
  • 96.4 (n)
dog
(Canis familiaris)
Mammalia TNFRSF1B 34 35
  • 79.89 (n)
cow
(Bos Taurus)
Mammalia TNFRSF1B 34 35
  • 78.19 (n)
mouse
(Mus musculus)
Mammalia Tnfrsf1b 34 16 35
  • 74.25 (n)
rat
(Rattus norvegicus)
Mammalia Tnfrsf1b 34
  • 72.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TNFRSF1B 35
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNFRSF1B 34 35
  • 45.34 (n)
zebrafish
(Danio rerio)
Actinopterygii tnfrsf1b 35
  • 26 (a)
OneToOne
Species where no ortholog for TNFRSF1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF1B Gene

ENSEMBL:
Gene Tree for TNFRSF1B (if available)
TreeFam:
Gene Tree for TNFRSF1B (if available)

Paralogs for TNFRSF1B Gene

Paralogs for TNFRSF1B Gene

(3) SIMAP similar genes for TNFRSF1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TNFRSF1B: view

Variants for TNFRSF1B Gene

Sequence variations from dbSNP and Humsavar for TNFRSF1B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10157774 -- 12,207,445(+) CTTTT(C/T)TGCAG utr-variant-3-prime
rs1061622 -- 12,192,898(+) AAGCA(G/T)GGATG reference, missense
rs1061624 -- 12,207,208(+) CAGCG(A/G)GTTGT utr-variant-3-prime
rs1061628 -- 12,207,942(+) AATGC(C/T)AACTT utr-variant-3-prime
rs1061631 -- 12,208,442(+) GTGTC(A/G)TGGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF1B Gene

Variant ID Type Subtype PubMed ID
nsv545437 CNV loss 21841781
nsv527024 CNV loss 19592680
nsv508891 CNV insertion 20534489
nsv471622 CNV gain+loss 15918152
nsv469830 CNV loss 16826518
nsv1145321 CNV deletion 24896259
esv3584475 CNV gain 24956385
dgv113n54 CNV loss 21841781
dgv112n54 CNV loss 21841781

Variation tolerance for TNFRSF1B Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.95; 79.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF1B Gene

Human Gene Mutation Database (HGMD)
TNFRSF1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF1B Gene

Disorders for TNFRSF1B Gene

MalaCards: The human disease database

(58) MalaCards diseases for TNFRSF1B Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mycosis fungoides
  • mf
sezary's disease
  • sezary disease
orbital plasma cell granuloma
  • orbital myositis
esophageal tuberculosis
  • tuberculosis of esophagus
chronic orbital inflammation
  • chronic inflammation of orbit
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFRSF1B

Genetic Association Database (GAD)
TNFRSF1B
Human Genome Epidemiology (HuGE) Navigator
TNFRSF1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFRSF1B
genes like me logo Genes that share disorders with TNFRSF1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF1B Gene

Publications for TNFRSF1B Gene

  1. Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism. (PMID: 12161545) Peral B. … Escobar-Morreale H.F. (J. Clin. Endocrinol. Metab. 2002) 3 4 22 46 64
  2. Association of tumor necrosis factor receptor type II polymorphism 196R with systemic lupus erythematosus in the Japanese: molecular and functional analysis. (PMID: 11762942) Morita C. … Niho Y. (Arthritis Rheum. 2001) 3 4 22 46 64
  3. New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus. (PMID: 11197692) Tsuchiya N. … Tokunaga K. (Genes Immun. 2000) 3 4 22 46 64
  4. Single nucleotide polymorphisms in TNF-alpha, TNFR2 gene and TNF-alpha production in Asian Indians. (PMID: 19811435) Gupta R. … Das S.N. (Immunol. Invest. 2009) 3 22 46 64
  5. Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design. (PMID: 19557004) Eguchi T. … Saruta T. (Hypertens. Res. 2009) 3 22 46 64

Products for TNFRSF1B Gene

Sources for TNFRSF1B Gene

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