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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF1A Gene

protein-coding   GIFtS: 70
GCID: GC12M006412

Tumor Necrosis Factor Receptor Superfamily, Member 1A


(Previous symbol: TNFR1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 1A1 2     TNF-R552
TNFR11 2 3 5     TNFR1-d22
TNFAR2 3 5     TNFR552
TNF-R12 3     TNFR602
TNF-RI2 3     p55-R2
TNFR-I2 3     Tumor Necrosis Factor Binding Protein 12
p552 3     Tumor Necrosis Factor Receptor 1A Isoform Beta2
p602 3     Tumor Necrosis Factor Receptor Superfamily Member 1A2
FPF2 5     Tumor Necrosis Factor Receptor Type 12
CD120a2     Tumor Necrosis Factor-Alpha Receptor2
MS52     CD120a Antigen3
TBP12     Tumor Necrosis Factor Receptor 13
TNF-R2     Tumor Necrosis Factor Receptor Type I3
TNF-R-I2     

External Ids:    HGNC: 119161   Entrez Gene: 71322   Ensembl: ENSG000000671827   OMIM: 1911905   UniProtKB: P194383   

Export aliases for TNFRSF1A gene to outside databases

Previous GC identifers: GC12M006292 GC12M006308


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF1A Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major
receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and
function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and
adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles
in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this
receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor
clearance is thought to be a mechanism of the disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFRSF1A Gene: 
TNFRSF1A (tumor necrosis factor receptor superfamily, member 1A) is a protein-coding gene. Diseases associated with TNFRSF1A include periodic fever, familial, autosomal dominant, and intermittent hydrarthrosis, and among its related super-pathways are HIV-1 Nef- Negative effector of Fas and TNF-alpha and TNF Signaling. GO annotations related to this gene include protein complex binding and tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF25.

UniProtKB/Swiss-Prot: TNR1A_HUMAN, P19438
Function: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD
recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs
caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine
proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral
state and activation of the acid sphingomyelinase

Gene Wiki entry for TNFRSF1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009759.16  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF1A gene promoter:
         CREB   STAT1   AP-1   deltaCREB   STAT1beta   STAT3   STAT5A   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): TNFRSF1A promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.2

TNFRSF1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF1A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M006412:  view genomic region     (about GC identifiers)

Start:
6,437,923 bp from pter      End:
6,451,283 bp from pter
Size:
13,361 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNR1A_HUMAN, P19438 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 1A precursor  
Size: 455 amino acids; 50495 Da
Subunit: Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains
provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various
TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their
association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B
signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. Interacts
with human cytomegalovirus/HHV-5 protein UL138
Subcellular location: Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass
type I membrane protein. Secreted. Note=A secreted form is produced through proteolytic processing
Subcellular location: Isoform 4: Secreted. Note=Lacks a Golgi-retention motif, is not membrane bound and therefore
is secreted
5 PDB 3D structures from and Proteopedia for TNFRSF1A:
1EXT (3D)        1FT4 (3D)        1ICH (3D)        1NCF (3D)        1TNR (3D)    
Secondary accessions: A8K4X3 B2RDE4 B3KPQ1 B4DQB7 B4E309 B5M0B5 D3DUR1 Q9UCA4
Alternative splicing: 5 isoforms:  P19438-1   P19438-2   P19438-4   P19438-3   P19438-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNFRSF1A: NX_P19438

Explore proteomics data for TNFRSF1A at MOPED 

Post-translational modifications:

  • UniProtKB: The soluble form is produced from the membrane form by proteolytic processing
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P19438

  • TNFRSF1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNFRSF1A Protein Expression
    REFSEQ proteins: NP_001056.1  
    ENSEMBL proteins: 
     ENSP00000441803   ENSP00000162749   ENSP00000442405   ENSP00000438343   ENSP00000442059  
     ENSP00000380389   ENSP00000439981   ENSP00000413224   ENSP00000442919  
    Reactome Protein details: P19438
    Human Recombinant Protein Products for TNFRSF1A: 
    EMD Millipore Purified and/or Recombinant TNFRSF1A Protein
    R&D Systems Recombinant & Natural Proteins for TNFRSF1A (TNF RI/TNFRSF1A)
    Enzo Life Sciences proteins for TNFRSF1A
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TNFRSF1A
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TNFRSF1A
    GenScript Custom Purified and Recombinant Proteins Services for TNFRSF1A
    Novus Biologicals TNFRSF1A Proteins
    Novus Biologicals TNFRSF1A Lysate
    Sino Biological Recombinant Protein for TNFRSF1A
    Sino Biological Cell Lysate for TNFRSF1A 
    ProSpec Recombinant Protein for TNFRSF1A
    Cloud-Clone Corp. Proteins for TNFRSF1A 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IDA--
    GO:0005576extracellular region NAS12189246
    GO:0005615extracellular space IDA13130484
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane TAS--

    TNFRSF1A for ontologies           About GeneDecksing



    TNFRSF1A Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TNFRSF1A
    R&D Systems Antibodies for TNFRSF1A (TNF RI/TNFRSF1A)
    Cell Signaling Technology (CST) Antibodies for TNFRSF1A  (TNF-R1)
    OriGene Antibodies for TNFRSF1A
    OriGene Custom Antibody Services for TNFRSF1A
    GenScript Custom Superior Antibodies Services for TNFRSF1A
    Novus Biologicals TNFRSF1A Antibodies
    Abcam antibodies for TNFRSF1A
    Cloud-Clone Corp. Antibodies for TNFRSF1A 
    ThermoFisher Antibodies for TNFRSF1A
    LSBio Antibodies in human, mouse, rat for TNFRSF1A 

    Assay Products for TNFRSF1A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TNFRSF1A
    R&D Systems ELISAs for TNFRSF1A (TNF RI/TNFRSF1A)         (see all)
    GenScript Custom Assay Services for TNFRSF1A
    Enzo Life Sciences assays for TNFRSF1A
    Cloud-Clone Corp. ELISAs for TNFRSF1A 
    Cloud-Clone Corp. CLIAs for TNFRSF1A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: tumor necrosis factor receptor 1 
    Tumour necrosis factor (TNF) receptor family

    4 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR020419 TNFR_1A
     IPR011029 DEATH-like_dom
     IPR000488 Death_domain

    Graphical View of Domain Structure for InterPro Entry P19438

    ProtoNet protein and cluster: P19438

    2 Blocks protein domains:
    IPB000488 Death domain
    IPB001368 TNFR/CD27/30/40/95 cysteine-rich region


    UniProtKB/Swiss-Prot: TNR1A_HUMAN, P19438
    Domain: The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain
    (NSD) is both necessary and sufficient for activation of N-SMASE
    Domain: Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are
    involved in the interaction with TRPC4AP (By similarity)
    Similarity: Contains 1 death domain
    Similarity: Contains 4 TNFR-Cys repeats


    TNFRSF1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR1A_HUMAN, P19438
    Function: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD
    recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs
    caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine
    proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral
    state and activation of the acid sphingomyelinase

         Genatlas biochemistry entry for TNFRSF1A:
    tumor necrosis factor receptor superfamily,member 1A,involved at least in two independent pathways,acidic
    sphingomyelinase controlling expression of multiple TNF-responsive genes,including the apoptotic pathway,neutral
    sphingomyelinase critical for the inflammatory and proliferative responses induced by TNF

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IEA--
    GO:0005031tumor necrosis factor-activated receptor activity TAS2158863
    GO:0005515protein binding IPI10848577
    GO:0032403protein complex binding IEA--
    GO:0043120tumor necrosis factor binding IEA--
         
    TNFRSF1A for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TNFRSF1A:
     Cell cycle / mitosis defect  Decreased viability  Increased TP53 protein express  Lamellipodia and high actin ra 

         15/24 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Tnfrsf1a) (see all 24):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    TNFRSF1A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TNFRSF1A: Tnfrsf1atm1Blt Tnfrsf1atm1Imx Tnfrsf1atm2Gkl Tnfrsf1atm1Gkl Tnfrsf1atm1Mak

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNFRSF1A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNFRSF1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF1A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF1A 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFRSF1A
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFRSF1A:
    hsa-miR-4251 hsa-miR-539 hsa-miR-29c hsa-miR-29a hsa-miR-4280 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF1A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TNFRSF1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFRSF1A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TNFRSF1A
    Sirion Biotech Customized adenovirus for overexpression of TNFRSF1A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TNFRSF1A (see all 8)
    OriGene ORF clones in mouse, rat for TNFRSF1A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNFRSF1A (NM_001065)
    Sino Biological Human cDNA Clone for TNFRSF1A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF1A
    Sirion Biotech Customized lentivirus for stable overexpression of TNFRSF1A 
                         Customized lentivirus expression plasmids for stable overexpression of TNFRSF1A 

    Cell Line
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    Search LifeMap BioReagents cell lines for TNFRSF1A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF1A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNFRSF1A About   (see all 54)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    TNFR1 Pathway0.56
    Apoptotic Pathways Triggered By HIV10.42
    TNF Signaling0.55
    Apoptosis through Death Receptors0.42
    Apoptosis and survival TNFR1 signaling pathway0.52
    Apoptosis Modulation by HSP700.35
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    2TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    3PEDF Induced Signaling
    PGC1Alpha Pathway0.51
    Glucocorticoid Receptor Signaling0.43
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Alzheimer's disease0.46
    Non-alcoholic fatty liver disease (NAFLD)0.41
    Alzheimers Disease0.44
    5Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    Caspase cascade in apoptosis0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 EMD Millipore Pathways for TNFRSF1A (see all 9)
        Transcription NF-kB signaling pathway
    Apoptosis and survival TNFR1 signaling pathway
    Apoptosis and survival Caspase cascade
    Immune response IL-9 signaling pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    4 R&D Systems Pathways for TNFRSF1A
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    Apoptosis Signaling Pathways
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

    5/40 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF1A (see all 40)
        Caspase Cascade
    THC Differentiation Pathway
    14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    2 Cell Signaling Technology (CST) Pathways for TNFRSF1A
        Apoptosis and Autophagy
    NF-kappaB Signaling

    5/9 GeneGo (Thomson Reuters) Pathways for TNFRSF1A (see all 9)
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival Caspase cascade
    Immune response IL-9 signaling pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival TNFR1 signaling pathway

    5/13 BioSystems Pathways for TNFRSF1A (see all 13)
        Apoptosis
    Apoptosis Modulation and Signaling
    TNF-alpha/NF-kB Signaling Pathway
    Apoptosis Modulation by HSP70
    Alzheimers Disease

    3 Sino Biological Pathways for TNFRSF1A 
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    4        Reactome Pathways for TNFRSF1A
        Death Receptor Signalling
    TNF signaling
    Extrinsic Pathway for Apoptosis
    Apoptosis


    5/17         Kegg Pathways  (Kegg details for TNFRSF1A) (see all 17):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    NF-kappa B signaling pathway
    Apoptosis
    Osteoclast differentiation


    TNFRSF1A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/271 Interacting proteins for TNFRSF1A (P194381, 2, 3 ENSP000001627494) via UniProtKB, MINT, STRING, and/or I2D (see all 271)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000228849P013751, 2, 3, ENSP000004106684EBI-299451,EBI-359977 MINT-48045 MINT-49295 I2D: score=12 STRING: ENSP00000410668
    ENSG00000204490P013751, 2, 3EBI-299451,EBI-359977 MINT-48045 MINT-49295 I2D: score=12 
    ENSG00000206439P013751, 2, 3EBI-299451,EBI-359977 MINT-48045 MINT-49295 I2D: score=12 
    ENSG00000223952P013751, 2, 3EBI-299451,EBI-359977 MINT-48045 MINT-49295 I2D: score=12 
    ENSG00000230108P013751, 2, 3EBI-299451,EBI-359977 MINT-48045 MINT-49295 I2D: score=12 
    About this table

    Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0006693prostaglandin metabolic process IEA--
    GO:0006915apoptotic process TAS--
    GO:0006952defense response ----
    GO:0006954inflammatory response ISS--

    TNFRSF1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNFRSF1A for compounds           About GeneDecksing

    EMD Millipore small molecules for TNFRSF1A:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFRSF1A (TNR1A)

    1 DrugBank Compound for TNFRSF1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One-- --target--17139284 17016423 10592235

    3 IUPHAR Ligands for TNFRSF1A (tumor necrosis factor receptor 1)    About this table 
    LigandTypeActionAffinityPubmed IDs
    tumour necrosis factor shed form
    NoneNone--
    lymphotoxin-α
    NoneNone--
    tumour necrosis factor membrane form
    NoneNone--

    10/108 Novoseek inferred chemical compound relationships for TNFRSF1A gene (see all 108)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    solamargine 68.7 7 8954074 (2), 18078328 (1), 11108802 (1)
    etanercept 67.5 33 11458980 (2), 12452839 (2), 18408954 (2), 10949736 (1) (see all 25)
    tab-1 62.9 2 17439942 (1), 17673602 (1)
    tri (d) 60 4 16631736 (1), 15357952 (1)
    bcma 56 7 9846698 (2), 10903733 (2), 16357320 (1), 14720511 (1)
    infliximab 43.3 12 16265686 (2), 19180495 (2), 17618693 (1), 15372221 (1) (see all 7)
    ceramide 42.1 12 15721320 (2), 9810003 (1), 15817701 (1), 9743381 (1) (see all 9)
    endotoxin 36.9 23 9950912 (3), 9684796 (3), 9075062 (2), 10353534 (2) (see all 10)
    cysteine 30.1 27 7567962 (3), 9921712 (2), 10964568 (1), 11175303 (1) (see all 20)
    gp 130 27.9 7 10622477 (1), 9890661 (1), 10414448 (1), 18779056 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about TNFRSF1A / TNR1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNFRSF1A gene: 
    NM_001065.3  

    Unigene Cluster for TNFRSF1A:

    Tumor necrosis factor receptor superfamily, member 1A
    Hs.279594  [show with all ESTs]
    Unigene Representative Sequence: NM_001065
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534885(uc010sez.2) ENST00000162749(uc001qnt.3 uc001qnu.3 uc010sey.2 uc009zek.3)
    ENST00000536717 ENST00000543995 ENST00000540022 ENST00000543359 ENST00000537842
    ENST00000535038 ENST00000539372 ENST00000366159(uc010sfa.2) ENST00000437813
    ENST00000543048 ENST00000440083 ENST00000536194 ENST00000535958 ENST00000538363

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK056611.1 AK291088.1 AK308061.1 AK315509.1 AY182755.1 BC010140.2 EU927389.1 JN172914.1 
    M33294.1 M58286.1 M60275.1 M63121.1 

    24/33 DOTS entries (see all 33):

    DT.100834768  DT.100834760  DT.100834763  DT.95320606  DT.100834766  DT.100834775  DT.100834769  DT.65286582 
    DT.100837461  DT.121189379  DT.100840631  DT.121189284  DT.121189378  DT.121189349  DT.91847911  DT.121189298 
    DT.121189408  DT.121189292  DT.121189354  DT.95137577  DT.121189228  DT.121189242  DT.121189380  DT.40208840 

    24/368 AceView cDNA sequences (see all 368):

    CD671768 BM756214 BU632029 CN483482 BM982071 BM694442 BM820201 BM742388 
    AU124156 AI288658 AI744147 BX397891 CA310058 BM847925 BE857215 CR593985 
    CD515445 CD014069 BG035257 BE673247 BG056664 CD672265 AU125680 CB131061 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF1A (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^
    SP1:                                      -                 -                                                           -           -     -                     
    SP2:                                      -                 -                             -     -                       -           -     -                     
    SP3:                                      -           -     -     -     -                                               -           -     -                     
    SP4:                                                                                                                    -                 -                     
    SP5:                                                                                                                    -           -     -     -               

    ExUns: 12 ^ 13 ^ 14
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for TNFRSF1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFRSF1A expression in normal human tissues (normalized intensities)      TNFRSF1A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACACTAAT
    TNFRSF1A Expression
    About this image


    TNFRSF1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Blood Brain Barrier (Nervous System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             leukocytes   

    See TNFRSF1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFRSF1A

    SOURCE GeneReport for Unigene cluster: Hs.279594
        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF1A (see all 14): 
              Multiple Sclerosis in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Apoptosis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Diabetes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF1A gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf1a1 , 5 tumor necrosis factor receptor superfamily, member more1, 5 73.47(n)1
    66.21(a)1
      6 (59.32 cM)5
    219371  NM_011609.41  NP_035739.21 
     1253493625 
    chicken
    (Gallus gallus)
    Aves TNFRSF1A1 tumor necrosis factor receptor superfamily, member more 50.24(n)
    39.66(a)
      418325  NM_001030779.1  NP_001025950.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNFRSF1A6
    tumor necrosis factor receptor superfamily, member...
    29(a)
    1 ↔ 1
    GL343473.1(582963-619074)
    zebrafish
    (Danio rerio)
    Actinopterygii tnfrsf1a1 tumor necrosis factor receptor superfamily, member more 45.01(n)
    29.62(a)
      406471  NM_213190.1  NP_998355.1 


    ENSEMBL Gene Tree for TNFRSF1A (if available)
    TreeFam Gene Tree for TNFRSF1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFRSF1A gene
    TNFRSF252  

    TNFRSF1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/597 SNPs in TNFRSF1A are shown (see all 597)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0193314
    Familial hibernian fever (FHF)4--see VAR_0193312 S G mis40--------
    VAR_0193034
    Familial hibernian fever (FHF)4--see VAR_0193032 C G mis40--------
    VAR_0134154
    Familial hibernian fever (FHF)4--see VAR_0134152 C Y mis40--------
    VAR_0134104
    Familial hibernian fever (FHF)4--see VAR_0134102 C R mis40--------
    VAR_0193024
    Familial hibernian fever (FHF)4--see VAR_0193022 C S mis40--------
    VAR_0134134
    Familial hibernian fever (FHF)4--see VAR_0134132 C F mis40--------
    VAR_0193294
    Familial hibernian fever (FHF)4--see VAR_0193292 H Q mis40--------
    VAR_0193044
    Familial hibernian fever (FHF)4--see VAR_0193042 C S mis40--------
    VAR_0134124
    Familial hibernian fever (FHF)4--see VAR_0134122 T M mis40--------
    VAR_0134114
    Familial hibernian fever (FHF)4--see VAR_0134112 C Y mis40--------

    HapMap Linkage Disequilibrium report for TNFRSF1A (6437923 - 6451283 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TNFRSF1A: --

    Human Gene Mutation Database (HGMD): TNFRSF1A

    Locus Specific Mutation Databases (LSDB): TNFRSF1A
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 191190   
    OMIM disorders: 142680  
    UniProtKB/Swiss-Prot: TNR1A_HUMAN, P19438
  • Familial hibernian fever (FHF) [MIM:142680]: A hereditary periodic fever syndrome characterized by
    recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main
    complication and occurs in 25% of cases. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Multiple sclerosis 5 (MS5) [MIM:614810]: A multifactorial, inflammatory, demyelinating disease of the
    central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and
    lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological
    mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral
    immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of
    sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors
    influence susceptibility to the disease. Note=Disease susceptibility is associated with variations affecting the
    gene represented in this entry. An intronic mutation affecting alternative splicing and skipping of exon 6
    directs increased expression of isoform 4 a transcript encoding a C-terminally truncated protein which is
    secreted and may function as a TNF antagonist

  • 20/196 diseases for TNFRSF1A (see all 196):    About MalaCards
    periodic fever, familial, autosomal dominant    intermittent hydrarthrosis    idiopathic recurrent pericarditis    sympathetic ophthalmia
    hyper-igd syndrome    palindromic rheumatism    wells syndrome    paracoccidioidomycosis
    pediatric systemic lupus erythematosus    cowpox    paratyphoid fever    muckle-wells syndrome
    relapsing fever    post-transplant lymphoproliferative disease    intestinal disease    familial mediterranean fever
    ankylosis    uveitis    adult-onset still's disease    spondylitis

    7 diseases from the University of Copenhagen DISEASES database for TNFRSF1A:
    Arthritis     Cancer     Inflammatory bowel disease     Multiple sclerosis
    Hypersensitivity reaction type II disease     Lung disease     Vascular disease

    TNFRSF1A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/91 Novoseek inferred disease relationships for TNFRSF1A gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumor necrosis factor receptor-associated periodic syndrome 92.3 36 11817598 (2), 15492850 (2), 15570662 (2), 11318938 (1) (see all 26)
    necrosis 92 1452 10561634 (6), 7573266 (5), 1648538 (5), 12406325 (4) (see all 99)
    tumors 82.5 1294 10561634 (6), 7573266 (5), 14598359 (5), 1648538 (5) (see all 99)
    hereditary periodic fever syndromes 71.6 1 15071491 (1)
    relapsing fever 61 12 11953985 (3), 10902757 (2), 15071491 (1), 11175303 (1) (see all 6)
    rheumatoid arthritis 59.8 41 9391689 (6), 9219699 (2), 7621589 (2), 9290265 (2) (see all 27)
    inflammation 59.3 55 9391689 (2), 17852784 (2), 9865650 (2), 9330935 (1) (see all 44)
    familial mediterranean fever 56.6 8 11318938 (1), 16019157 (1), 12209523 (1), 15502081 (1) (see all 6)
    muckle-wells syndrome 53.4 1 16019157 (1)
    autoimmune diseases 41.8 21 15280569 (1), 19386778 (1), 20173385 (1), 11007755 (1) (see all 15)

    Genetic Association Database (GAD): TNFRSF1A
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF1A (132 documents)

    Export disorders for TNFRSF1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFRSF1A gene, integrated from 9 sources (see all 1408):
    (articles sorted by number of sources associating them with TNFRSF1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a receptor for human tumor necrosis factor. (PubMed id 2158863)1, 2, 3, 9 Schall T.J....Raab H. (1990)
    2. Heterogeneity among patients with tumor necrosis factor receptor- associated periodic syndrome phenotypes. (PubMed id 13130484)1, 2, 4, 9 Aganna E.... McDermott M.F. (2003)
    3. A TNFR1 genotype with a protective role in familial rheumatoid arthritis. (PubMed id 14872483)1, 4, 9 Dieude P....Cornelis F. (2004)
    4. A novel missense mutation (C30S) in the gene encoding tumor necrosis factor receptor 1 linked to autosomal-dominant recurrent fever with localized myositis in a French family. (PubMed id 10902757)1, 2, 9 Dode C.... Grateau G. (2000)
    5. Association of polymorphisms of the tumour necrosis factor receptors I and II and rheumatoid arthritis. (PubMed id 12730509)1, 4, 9 Bayley J.P....Verweij C.L. (2003)
    6. Structure of the human TNF receptor 1 (p60) gene (TNFR1) and localization to chromosome 12p13. (PubMed id 1315717)1, 2, 9 Fuchs P.... Ambros P.F. (1992)
    7. The role of tumor necrosis factor (TNF)-alpha and TNF receptor polymorphisms in susceptibility to ankylosing spondylitis. (PubMed id 19772798)1, 4, 9 Chatzikyriakidou A....Drosos A.A. (2009)
    8. A potential role of TNFR gene polymorphisms in autoimmune thyroid diseases in the Tunisian population. (PubMed id 18571427)1, 4, 9 Kammoun-Krichen M....Ayadi H. (2008)
    9. Tumor necrosis factor receptor gene polymorphisms in Crohn's disease: association with clinical phenotypes. (PubMed id 15842589)1, 4, 9 Waschke K.A....Wild G.E. (2005)
    10. Anemia in rheumatoid arthritis: association with polymorphism in the tumor necrosis factor receptor I and II genes. (PubMed id 16142859)1, 4, 9 Glossop J.R....Mattey D.L. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7132 HGNC: 11916 AceView: TNFRSF1A Ensembl:ENSG00000067182 euGenes: HUgn7132
    ECgene: TNFRSF1A Kegg: 7132 H-InvDB: TNFRSF1A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFRSF1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF1A Genetics and Cytogenetics in Oncology and Haematology
    INFEVERShttp://fmf.igh.cnrs.fr/ISSAID/infevers/search.php?n=2
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TNFRSF1A
    SeattleSNPshttp://pga.gs.washington.edu/data/tnfrsf1a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNFRSF1A gene:
    Search GeneIP for patents involving TNFRSF1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF1A
     SwitchGear 3'UTR luciferase reporter plasmids for TNFRSF1A
     SwitchGear Promoter luciferase reporter plasmids for TNFRSF1A
     ThermoFisher Antibodies for TNFRSF1A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF1A
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TNFRSF1A
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNFRSF1A
    Customized:
     lentivirus for stable overexpression of TNFRSF1A
     lentivirus expression plasmids for stable overexpression of TNFRSF1A
     adenovirus for overexpression of TNFRSF1A
     LSBio Antibodies in human, mouse, rat for TNFRSF1A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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