Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TNFRSF1A Gene

protein-coding   GIFtS: 71
GCID: GC12M006412

Tumor Necrosis Factor Receptor Superfamily, Member 1A


(Previous symbol: TNFR1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 1A1 2     TNF-R552
TNFR11 2 3 5     TNFR1-d22
TNFAR2 3 5     TNFR552
TNF-R12 3     TNFR602
TNF-RI2 3     p55-R2
TNFR-I2 3     Tumor Necrosis Factor Binding Protein 12
p552 3     Tumor Necrosis Factor Receptor 1A Isoform Beta2
p602 3     Tumor Necrosis Factor Receptor Superfamily Member 1A2
FPF2 5     Tumor Necrosis Factor Receptor Type 12
MS52 5     Tumor Necrosis Factor-Alpha Receptor2
CD120a2     CD120a Antigen3
TBP12     Tumor Necrosis Factor Receptor 13
TNF-R2     Tumor Necrosis Factor Receptor Type I3
TNF-R-I2     

External Ids:    HGNC: 119161   Entrez Gene: 71322   Ensembl: ENSG000000671827   OMIM: 1911905   UniProtKB: P194383   

Export aliases for TNFRSF1A gene to outside databases

Previous GC identifers: GC12M006292 GC12M006308


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TNFRSF1A Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major
receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and
function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and
adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles
in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this
receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor
clearance is thought to be a mechanism of the disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFRSF1A Gene:
TNFRSF1A (tumor necrosis factor receptor superfamily, member 1A) is a protein-coding gene. Diseases associated with TNFRSF1A include periodic fever, familial, autosomal dominant, and multiple sclerosis 5. GO annotations related to this gene include protein complex binding and tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF25.

UniProtKB/Swiss-Prot: TNR1A_HUMAN, P19438
Function: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD
recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs
caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine
proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral
state and activation of the acid sphingomyelinase

Gene Wiki entry for TNFRSF1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009759.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFRSF1A gene promoter:
         CREB   STAT1   AP-1   deltaCREB   STAT1beta   STAT3   STAT5A   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): TNFRSF1A promoter sequence
   Search Chromatin IP Primers for TNFRSF1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.2

TNFRSF1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF1A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M006412:  view genomic region     (about GC identifiers)

Start:
6,437,923 bp from pter      End:
6,451,283 bp from pter
Size:
13,361 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TNR1A_HUMAN, P19438 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 1A precursor  
Size: 455 amino acids; 50495 Da
Subunit: Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains
provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various
TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their
association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B
signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. Interacts
with human cytomegalovirus/HHV-5 protein UL138
5 PDB 3D structures from and Proteopedia for TNFRSF1A:
1EXT (3D)        1FT4 (3D)        1ICH (3D)        1NCF (3D)        1TNR (3D)    
Secondary accessions: A8K4X3 B2RDE4 B3KPQ1 B4DQB7 B4E309 B5M0B5 D3DUR1 Q9UCA4
Alternative splicing: 5 isoforms:  P19438-1   P19438-2   P19438-4   P19438-3   P19438-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNFRSF1A: NX_P19438

Explore proteomics data for TNFRSF1A at MOPED

Post-translational modifications: 

  • The soluble form is produced from the membrane form by proteolytic processing1
  • Glycosylation2 at Asn54, Asn145, Asn151
  • Modification sites at PhosphoSitePlus

  • See TNFRSF1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001056.1  
    ENSEMBL proteins: 
     ENSP00000441803   ENSP00000162749   ENSP00000442405   ENSP00000438343   ENSP00000442059  
     ENSP00000380389   ENSP00000439981   ENSP00000413224   ENSP00000442919  
    Reactome Protein details: P19438

    TNFRSF1A Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant TNFRSF1A Protein
    R&D Systems Recombinant & Natural Proteins for TNFRSF1A (TNF RI/TNFRSF1A)
    Enzo Life Sciences proteins for TNFRSF1A
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TNFRSF1A
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TNFRSF1A
    GenScript Custom Purified and Recombinant Proteins Services for TNFRSF1A
    Novus Biologicals TNFRSF1A Proteins
    Novus Biologicals TNFRSF1A Lysate
    Sino Biological Recombinant Protein for TNFRSF1A
    Sino Biological Cell Lysate for TNFRSF1A
    ProSpec Recombinant Protein for TNFRSF1A
    Cloud-Clone Corp. Proteins for TNFRSF1A

    TNFRSF1A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TNFRSF1A
    R&D Systems Antibodies for TNFRSF1A (TNF RI/TNFRSF1A)
    Cell Signaling Technology (CST) Antibodies for TNFRSF1A  (TNF-R1)
    OriGene Antibodies for TNFRSF1A
    OriGene Custom Antibody Services for TNFRSF1A
    Novus Biologicals TNFRSF1A Antibodies
    Abcam antibodies for TNFRSF1A (P19438, Q15628)
    Cloud-Clone Corp. Antibodies for TNFRSF1A
    ThermoFisher Antibodies for TNFRSF1A
    LSBio Antibodies in human, mouse, rat for TNFRSF1A

    TNFRSF1A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TNFRSF1A
    R&D Systems ELISAs for TNFRSF1A (TNF RI/TNFRSF1A)         (see all)
    GenScript Custom Assay Services for TNFRSF1A
    Enzo Life Sciences assays for TNFRSF1A
    Cloud-Clone Corp. ELISAs for TNFRSF1A
    Cloud-Clone Corp. CLIAs for TNFRSF1A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: tumor necrosis factor receptor 1
    Tumour necrosis factor (TNF) receptor family

    4 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR020419 TNFR_1A
     IPR011029 DEATH-like_dom
     IPR000488 Death_domain

    Graphical View of Domain Structure for InterPro Entry P19438

    ProtoNet protein and cluster: P19438

    2 Blocks protein domains:
    IPB000488 Death domain
    IPB001368 TNFR/CD27/30/40/95 cysteine-rich region


    UniProtKB/Swiss-Prot: TNR1A_HUMAN, P19438
    Domain: The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain
    (NSD) is both necessary and sufficient for activation of N-SMASE
    Domain: Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are
    involved in the interaction with TRPC4AP (By similarity)
    Similarity: Contains 1 death domain
    Similarity: Contains 4 TNFR-Cys repeats


    TNFRSF1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR1A_HUMAN, P19438
    Function: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD
    recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs
    caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine
    proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral
    state and activation of the acid sphingomyelinase

         Genatlas biochemistry entry for TNFRSF1A:
    tumor necrosis factor receptor superfamily,member 1A,involved at least in two independent pathways,acidic
    sphingomyelinase controlling expression of multiple TNF-responsive genes,including the apoptotic pathway,neutral
    sphingomyelinase critical for the inflammatory and proliferative responses induced by TNF

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IEA--
    GO:0005031tumor necrosis factor-activated receptor activity TAS2158863
    GO:0005515protein binding IPI10848577
    GO:0032403protein complex binding IEA--
    GO:0043120tumor necrosis factor binding IEA--
         
    TNFRSF1A for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TNFRSF1A:
     Cell cycle / mitosis defect  Decreased viability  Increased TP53 protein express  Lamellipodia and high actin ra 

         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Tnfrsf1a) (see all 24):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    TNFRSF1A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TNFRSF1A: Tnfrsf1atm1Blt Tnfrsf1atm1Imx Tnfrsf1atm2Gkl Tnfrsf1atm1Gkl Tnfrsf1atm1Mak

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFRSF1A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNFRSF1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF1A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF1A

    miRNA
    Products:
        
    miRTarBase miRNAs that target TNFRSF1A:
    hsa-let-7e-5p (MIRT051697)

    Block miRNA regulation of human, mouse, rat TNFRSF1A using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate TNFRSF1A:
    hsa-miR-4251 hsa-miR-539 hsa-miR-29c hsa-miR-29a hsa-miR-4280 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF1A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TNFRSF1A
    Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF1A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TNFRSF1A

    Clone
    Products:
         
    OriGene clones in human, mouse for TNFRSF1A (see all 8)
    OriGene ORF clones in mouse, rat for TNFRSF1A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNFRSF1A (NM_001065)
    Sino Biological Human cDNA Clone for TNFRSF1A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF1A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TNFRSF1A
    Browse ESI BIO Cell Lines and PureStem Progenitors for TNFRSF1A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TNR1A_HUMAN, P19438: Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass
    type I membrane protein. Secreted. Note=A secreted form is produced through proteolytic processing
    TNR1A_HUMAN, P19438: Isoform 4: Secreted. Note=Lacks a Golgi-retention motif, is not membrane bound and therefore
    is secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus5
    plasma membrane5
    cytoskeleton2
    cytosol2
    mitochondrion2
    nucleus2
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IDA--
    GO:0005576extracellular region NAS12189246
    GO:0005615extracellular space IDA13130484
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane TAS--

    TNFRSF1A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TNFRSF1A About   (see all 55)  
    See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    TNFR1 Pathway0.56
    Apoptotic Pathways Triggered By HIV10.42
    TNF Signaling0.55
    Apoptosis through Death Receptors0.42
    Apoptosis and survival TNFR1 signaling pathway0.52
    Apoptosis Modulation by HSP700.35
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    2TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    3PEDF Induced Signaling
    PGC1Alpha Pathway0.51
    Glucocorticoid Receptor Signaling0.43
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    4Amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS)0.63
    Amyotrophic lateral sclerosis (ALS)0.63
    5Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 R&D Systems Pathways for TNFRSF1A
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    Apoptosis Signaling Pathways
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF1A (see all 40)
        Caspase Cascade
    THC Differentiation Pathway
    14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    2 Cell Signaling Technology (CST) Pathways for TNFRSF1A
        Apoptosis and Autophagy
    NF-kappaB Signaling

    Selected GeneGo (Thomson Reuters) Pathways for TNFRSF1A (see all 9)
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival Caspase cascade
    Immune response IL-9 signaling pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival TNFR1 signaling pathway

    Selected BioSystems Pathways for TNFRSF1A (see all 14)
        Apoptosis
    Apoptosis Modulation and Signaling
    Amyotrophic lateral sclerosis (ALS)
    TNF-alpha/NF-kB Signaling Pathway
    Apoptosis Modulation by HSP70

    3 Sino Biological Pathways for TNFRSF1A
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    1 Reactome Pathway for TNFRSF1A
        TNF signaling


    Selected Kegg Pathways  (Kegg details for TNFRSF1A) (see all 17):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    NF-kappa B signaling pathway
    Apoptosis
    Osteoclast differentiation


    TNFRSF1A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF1A (see all 14): 
              Multiple Sclerosis in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Apoptosis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFRSF1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNFRSF1A (P194381, 2, 3 ENSP000001627494) via UniProtKB, MINT, STRING, and/or I2D (see all 277)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000228849P013751, 2, 3, ENSP000004106684EBI-299451,EBI-359977 MINT-48045 MINT-49295 I2D: score=12 STRING: ENSP00000410668
    ENSG00000204490P013751, 2, 3EBI-299451,EBI-359977 MINT-48045 MINT-49295 I2D: score=12 
    ENSG00000206439P013751, 2, 3EBI-299451,EBI-359977 MINT-48045 MINT-49295 I2D: score=12 
    ENSG00000223952P013751, 2, 3EBI-299451,EBI-359977 MINT-48045 MINT-49295 I2D: score=12 
    ENSG00000230108P013751, 2, 3EBI-299451,EBI-359977 MINT-48045 MINT-49295 I2D: score=12 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0006693prostaglandin metabolic process IEA--
    GO:0006915apoptotic process TAS--
    GO:0006952defense response ----
    GO:0006954inflammatory response ISS--

    TNFRSF1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFRSF1A (TNR1A)

    1 DrugBank Compound for TNFRSF1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One-- --target--17139284 17016423 10592235

    3 IUPHAR Ligands for TNFRSF1A (tumor necrosis factor receptor 1)    About this table
    LigandTypeActionAffinityPubmed IDs
    tumour necrosis factor shed form
    NoneNone--
    lymphotoxin-alpha
    NoneNone--
    tumour necrosis factor membrane form
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for TNFRSF1A gene (see all 108)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    solamargine 68.7 7 8954074 (2), 18078328 (1), 11108802 (1)
    etanercept 67.5 33 11458980 (2), 12452839 (2), 18408954 (2), 10949736 (1) (see all 25)
    tab-1 62.9 2 17439942 (1), 17673602 (1)
    tri (d) 60 4 16631736 (1), 15357952 (1)
    bcma 56 7 9846698 (2), 10903733 (2), 16357320 (1), 14720511 (1)
    infliximab 43.3 12 16265686 (2), 19180495 (2), 17618693 (1), 15372221 (1) (see all 7)
    ceramide 42.1 12 15721320 (2), 9810003 (1), 15817701 (1), 9743381 (1) (see all 9)
    endotoxin 36.9 23 9950912 (3), 9684796 (3), 9075062 (2), 10353534 (2) (see all 10)
    cysteine 30.1 27 7567962 (3), 9921712 (2), 10964568 (1), 11175303 (1) (see all 20)
    gp 130 27.9 7 10622477 (1), 9890661 (1), 10414448 (1), 18779056 (1) (see all 5)



    TNFRSF1A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TNFRSF1A gene: 
    NM_001065.3  

    Unigene Cluster for TNFRSF1A:

    Tumor necrosis factor receptor superfamily, member 1A
    Hs.279594  [show with all ESTs]
    Unigene Representative Sequence: NM_001065
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534885(uc010sez.2) ENST00000162749(uc001qnt.3 uc001qnu.3 uc010sey.2 uc009zek.3)
    ENST00000536717 ENST00000543995 ENST00000540022 ENST00000543359 ENST00000537842
    ENST00000535038 ENST00000539372 ENST00000366159(uc010sfa.2) ENST00000437813
    ENST00000543048 ENST00000440083 ENST00000536194 ENST00000535958 ENST00000538363

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TNFRSF1A using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate TNFRSF1A:
    hsa-miR-4251 hsa-miR-539 hsa-miR-29c hsa-miR-29a hsa-miR-4280 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF1A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TNFRSF1A
    Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF1A
    Clone
    Products:
         
    OriGene clones in human, mouse for TNFRSF1A (see all 8)
    OriGene ORF clones in mouse, rat for TNFRSF1A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNFRSF1A (NM_001065)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF1A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TNFRSF1A
    OriGene qSTAR qPCR primer pairs in human, mouse for TNFRSF1A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNFRSF1A
      QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF1A
      QuantiFast Probe-based Assays in human, mouse, rat TNFRSF1A

    Additional mRNA sequence: 

    AK056611.1 AK291088.1 AK308061.1 AK315509.1 AY182755.1 BC010140.2 EU927389.1 JN172914.1 
    M33294.1 M58286.1 M60275.1 M63121.1 

    Selected DOTS entries (see all 33):

    DT.100834768  DT.100834760  DT.100834763  DT.95320606  DT.100834766  DT.100834775  DT.100834769  DT.65286582 
    DT.100837461  DT.121189379  DT.100840631  DT.121189284  DT.121189378  DT.121189349  DT.91847911  DT.121189298 
    DT.121189408  DT.121189292  DT.121189354  DT.95137577  DT.121189228  DT.121189242  DT.121189380  DT.40208840 

    Selected AceView cDNA sequences (see all 368):

    AI920999 AI802543 BG180101 BI769006 AI926747 BX282526 BM847870 CB131061 
    R52225 AI814001 BQ881180 BM763879 BM839984 CA446987 BI821169 AL577008 
    CB105436 BM708362 CD014069 CD515445 BQ027050 AU142163 BQ880824 CN481303 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF1A (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^
    SP1:                                      -                 -                                                           -           -     -                     
    SP2:                                      -                 -                             -     -                       -           -     -                     
    SP3:                                      -           -     -     -     -                                               -           -     -                     
    SP4:                                                                                                                    -                 -                     
    SP5:                                                                                                                    -           -     -     -               

    ExUns: 12 ^ 13 ^ 14
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for TNFRSF1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TNFRSF1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACACTAAT
    TNFRSF1A Expression
    About this image


    TNFRSF1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    TNFRSF1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFRSF1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279594
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF1A (see all 14): 
              Multiple Sclerosis in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Apoptosis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Diabetes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TNFRSF1A
    OriGene qSTAR qPCR primer pairs in human, mouse for TNFRSF1A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNFRSF1A
    QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF1A
    QuantiFast Probe-based Assays in human, mouse, rat TNFRSF1A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF1A gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf1a1 , 5 tumor necrosis factor receptor superfamily, member more1, 5 73.24(n)1
    66.21(a)1
      6 (59.32 cM)5
    219371  NM_011609.41  NP_035739.21 
     1253493625 
    chicken
    (Gallus gallus)
    Aves TNFRSF1A1 tumor necrosis factor receptor superfamily, member more 50.61(n)
    39.09(a)
      418325  NM_001030779.1  NP_001025950.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNFRSF1A6
    tumor necrosis factor receptor superfamily, member...
    31(a)
    1 ↔ 1
    GL343473.1(582963-619074)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tnfrsf1a1 tumor necrosis factor receptor superfamily, member more 48.29(n)
    41.27(a)
      100144930  NM_001126504.1  NP_001119976.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tnfrsf1a1 tumor necrosis factor receptor superfamily, member more 45.14(n)
    29.78(a)
      406471  NM_213190.1  NP_998355.1 


    ENSEMBL Gene Tree for TNFRSF1A (if available)
    TreeFam Gene Tree for TNFRSF1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TNFRSF1A gene
    TNFRSF252  

    TNFRSF1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TNFRSF1A (see all 597)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs41495841,2,,4
    C,F,HFamilial hibernian fever (FHF)4 pathogenic16373443(-) GGACCA/C/GGGACA 2 P R mis1 ese314NS EA NA EU 6947
    rs41496371,2,,4
    C,F,HFamilial hibernian fever (FHF)4 --6373801(-) AGGCCC/TGGGGC 2 P L mis1 ese318Minor allele frequency- T:0.04NS EA NA CSA WA EU 7347
    VAR_0193314
    Familial hibernian fever (FHF)4--see VAR_0193312 S G mis40--------
    VAR_0193034
    Familial hibernian fever (FHF)4--see VAR_0193032 C G mis40--------
    VAR_0134154
    Familial hibernian fever (FHF)4--see VAR_0134152 C Y mis40--------
    VAR_0134104
    Familial hibernian fever (FHF)4--see VAR_0134102 C R mis40--------
    VAR_0193024
    Familial hibernian fever (FHF)4--see VAR_0193022 C S mis40--------
    VAR_0134134
    Familial hibernian fever (FHF)4--see VAR_0134132 C F mis40--------
    VAR_0193294
    Familial hibernian fever (FHF)4--see VAR_0193292 H Q mis40--------
    VAR_0193044
    Familial hibernian fever (FHF)4--see VAR_0193042 C S mis40--------

    HapMap Linkage Disequilibrium report for TNFRSF1A (6437923 - 6451283 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TNFRSF1A: --
    Human Gene Mutation Database (HGMD): TNFRSF1A
    Locus Specific Mutation Databases (LSDB): TNFRSF1A

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFRSF1A
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFRSF1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 191190   
    OMIM disorders: 142680  614810  
    UniProtKB/Swiss-Prot: TNR1A_HUMAN, P19438
  • Familial hibernian fever (FHF) [MIM:142680]: A hereditary periodic fever syndrome characterized by
    recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main
    complication and occurs in 25% of cases. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Multiple sclerosis 5 (MS5) [MIM:614810]: A multifactorial, inflammatory, demyelinating disease of the
    central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and
    lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological
    mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral
    immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of
    sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors
    influence susceptibility to the disease. Note=Disease susceptibility is associated with variations affecting the
    gene represented in this entry. An intronic mutation affecting alternative splicing and skipping of exon 6
    directs increased expression of isoform 4 a transcript encoding a C-terminally truncated protein which is
    secreted and may function as a TNF antagonist

  • Selected diseases for TNFRSF1A (see all 201):    
    About MalaCards
    periodic fever, familial, autosomal dominant    multiple sclerosis 5    periodic fever, familial    tumor necrosis factor receptor-associated periodic syndrome
    idiopathic recurrent pericarditis    intermittent hydrarthrosis    sympathetic ophthalmia    hydrarthrosis
    muckle-wells syndrome    hyper-igd syndrome    cowpox    palindromic rheumatism
    wells syndrome    paratyphoid fever    paracoccidioidomycosis    relapsing fever
    pericarditis    post-transplant lymphoproliferative disease    tendinosis    intestinal disease

    7 diseases from the University of Copenhagen DISEASES database for TNFRSF1A:
    Arthritis     Cancer     Inflammatory bowel disease     Multiple sclerosis
    Hypersensitivity reaction type II disease     Lung disease     Vascular disease

    TNFRSF1A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for TNFRSF1A gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumor necrosis factor receptor-associated periodic syndrome 92.3 36 11817598 (2), 15492850 (2), 15570662 (2), 11318938 (1) (see all 26)
    necrosis 92 1452 10561634 (6), 7573266 (5), 1648538 (5), 12406325 (4) (see all 99)
    tumors 82.5 1294 10561634 (6), 7573266 (5), 14598359 (5), 1648538 (5) (see all 99)
    hereditary periodic fever syndromes 71.6 1 15071491 (1)
    relapsing fever 61 12 11953985 (3), 10902757 (2), 15071491 (1), 11175303 (1) (see all 6)
    rheumatoid arthritis 59.8 41 9391689 (6), 9219699 (2), 7621589 (2), 9290265 (2) (see all 27)
    inflammation 59.3 55 9391689 (2), 17852784 (2), 9865650 (2), 9330935 (1) (see all 44)
    familial mediterranean fever 56.6 8 11318938 (1), 16019157 (1), 12209523 (1), 15502081 (1) (see all 6)
    muckle-wells syndrome 53.4 1 16019157 (1)
    autoimmune diseases 41.8 21 15280569 (1), 19386778 (1), 20173385 (1), 11007755 (1) (see all 15)

    Genetic Association Database (GAD): TNFRSF1A
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF1A (132 documents)

    Export disorders for TNFRSF1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TNFRSF1A gene, integrated from 10 sources (see all 1432):
    (articles sorted by number of sources associating them with TNFRSF1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a receptor for human tumor necrosis factor. (PubMed id 2158863)1, 2, 3, 9 Schall T.J.... Goeddel D.V. (Cell 1990)
    2. Heterogeneity among patients with tumor necrosis factor receptor- associated periodic syndrome phenotypes. (PubMed id 13130484)1, 2, 4, 9 Aganna E.... McDermott M.F. (Arthritis Rheum. 2003)
    3. A TNFR1 genotype with a protective role in familial rheumatoid arthritis. (PubMed id 14872483)1, 4, 9 DieudAc P....CornAclis F. (Arthritis Rheum. 2004)
    4. A novel missense mutation (C30S) in the gene encoding tumor necrosis factor receptor 1 linked to autosomal-dominant recurrent fever with localized myositis in a French family. (PubMed id 10902757)1, 2, 9 Dode C.... Grateau G. (Arthritis Rheum. 2000)
    5. Association of polymorphisms of the tumour necrosis factor receptors I and II and rheumatoid arthritis. (PubMed id 12730509)1, 4, 9 Bayley J.P....Verweij C.L. (Rheumatology (Oxford) 2003)
    6. Structure of the human TNF receptor 1 (p60) gene (TNFR1) and localization to chromosome 12p13. (PubMed id 1315717)1, 2, 9 Fuchs P.... Ambros P.F. (Genomics 1992)
    7. The role of tumor necrosis factor (TNF)-alpha and TNF receptor polymorphisms in susceptibility to ankylosing spondylitis. (PubMed id 19772798)1, 4, 9 Chatzikyriakidou A....Drosos A.A. (Clin. Exp. Rheumatol. 2009)
    8. A potential role of TNFR gene polymorphisms in autoimmune thyroid diseases in the Tunisian population. (PubMed id 18571427)1, 4, 9 Kammoun-Krichen M....Ayadi H. (Cytokine 2008)
    9. Tumor necrosis factor receptor gene polymorphisms in Crohn's disease: association with clinical phenotypes. (PubMed id 15842589)1, 4, 9 Waschke K.A....Wild G.E. (Am. J. Gastroenterol. 2005)
    10. Anemia in rheumatoid arthritis: association with polymorphism in the tumor necrosis factor receptor I and II genes. (PubMed id 16142859)1, 4, 9 Glossop J.R....Mattey D.L. (J. Rheumatol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7132 HGNC: 11916 AceView: TNFRSF1A Ensembl:ENSG00000067182 euGenes: HUgn7132
    ECgene: TNFRSF1A Kegg: 7132 H-InvDB: TNFRSF1A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TNFRSF1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF1A Genetics and Cytogenetics in Oncology and Haematology
    INFEVERShttp://fmf.igh.cnrs.fr/ISSAID/infevers/search.php?n=2
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=TNFRSF1A[genesymbol]
    SeattleSNPshttp://pga.gs.washington.edu/data/tnfrsf1a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TNFRSF1A gene:
    Search GeneIP for patents involving TNFRSF1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TNFRSF1A
     EMD Millipore Purified and/or Recombinant TNFRSF1A Protein
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for TNFRSF1A (TNF RI/TNFRSF1A)   Browse Cell Culture Products  
     ELISAs for TNFRSF1A (TNF RI/TNFRSF1A)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Luminex Assays for TNFRSF1A (TNF RI/TNFRSF1A)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for TNFRSF1A (TNF RI/TNFRSF1A)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for TNFRSF1A (TNF RI/TNFRSF1A)  
     OriGene Antibodies for TNFRSF1A   OriGene RNAi products in human, mouse, rat for TNFRSF1A  
     OriGene qPCR primer pairs and template standards for TNFRSF1A   OriGene Protein Over-expression Lysate for TNFRSF1A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TNFRSF1A  
     OriGene qSTAR qPCR primer pairs in human, mouse for TNFRSF1A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TNFRSF1A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TNFRSF1A   OriGene Custom Protein Services for TNFRSF1A  

     
     
     Block miRNA regulation of human, mouse, rat TNFRSF1A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TNFRSF1A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF1A Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF1A
     QuantiFast Probe-based Assays in human, mouse, rat TNFRSF1A QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF1A
     PCR Arrays including human, mouse, rat TNFRSF1A Search Chromatin IP Primers for TNFRSF1A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNFRSF1A  GeneGlobe Interaction Network for TNFRSF1A
     Regulatory tfbs in TNFRSF1A promoter
     GenScript Custom Purified and Recombinant Proteins Services for TNFRSF1A GenScript cDNA clones with any tag delivered in your preferred vector for TNFRSF1A
     GenScript Custom Assay Services for TNFRSF1A GenScript Custom overexpressing Cell Line Services for TNFRSF1A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for TNFRSF1A  (TNF-R1)

     Search Tocris compounds for TNFRSF1A (TNR1A)
     Proteins for TNFRSF1A
     Cell Lysates for TNFRSF1A
     cDNA Clones for TNFRSF1A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays/Proteins for TNFRSF1A
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TNFRSF1A antibodies
     TNFRSF1A proteins
     TNFRSF1A lysates
     Antibodies for TNFRSF1A
     See all of Abcam's Antibodies, Kits and Proteins for TNFRSF1A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TNFRSF1A
     Proteins for TNFRSF1A
     Antibodies for TNFRSF1A
     ELISAs for TNFRSF1A
     CLIAs for TNFRSF1A



     Browse ESI BIO Cell Lines and PureStem Progenitors for TNFRSF1A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF1A
     SwitchGear 3'UTR luciferase reporter plasmids for TNFRSF1A
     SwitchGear Promoter luciferase reporter plasmids for TNFRSF1A
     ThermoFisher Antibodies for TNFRSF1A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF1A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFRSF1A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNFRSF1A
     LSBio Antibodies in human, mouse, rat for TNFRSF1A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TNFRSF1A gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4