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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF19 Gene

protein-coding   GIFtS: 63
GCID: GC13P024144

tumor necrosis factor receptor superfamily, member 19
 Explore 13 diseases affiliated with
TNFRSF19 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TNFRSF19    

Aliases
for TNFRSF19 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 191 2     TAJ-Alpha1
TAJ1 2 3 5     Toxicity And JNK Inducer2 3
TROY1 2 3 5     Tumor Necrosis Factor Receptor Superfamily Member 192
TRADE1 2 3     

External Ids:    HGNC: 119151   Entrez Gene: 555042   Ensembl: ENSG000001278637   OMIM: 6061225   UniProtKB: Q9NS683   

Export aliases for TNFRSF19 gene to outside databases

Previous GC identifers: GC13P022133 GC13P018133 GC13P023074 GC13P021942 GC13P023042 GC13P004956


Summaries
for TNFRSF19 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TNFRSF19:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during
embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway
when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it
is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding
distinct isoforms have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNR19_HUMAN, Q9NS68
Function: Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death

Gene Wiki entry for TNFRSF19


Genomic Views
for TNFRSF19 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF19 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF19 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.11-q12.3   Ensembl cytogenetic band:  13q12.12   HGNC cytogenetic band: 13q12.11-q12.3

TNFRSF19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF19 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P024144:  view genomic region     (about GC identifiers)

Start:
 24,144,509 bp from pter      End:
 24,250,232 bp from pter
Size:
 105,724 bases      Orientation:
 plus strand

Proteins
for TNFRSF19 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TNR19_HUMAN, Q9NS68 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 19 precursor  
Size: 423 amino acids; 46015 Da
Subunit: Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1
Subcellular location: Membrane; Single-pass type I membrane protein (Probable)
Secondary accessions: B1AM40 B1AM41 B4E2I6 Q9BXZ9 Q9BY00 Q9NZV2
Alternative splicing: 3 isoforms:  Q9NS68-1   Q9NS68-2   Q9NS68-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNFRSF19: NX_Q9NS68

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NS68

    • TNFRSF19 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001191387.1  NP_001191388.1  NP_061117.2  NP_683760.1  

    ENSEMBL proteins: 
     ENSP00000248484   ENSP00000371693   ENSP00000371698   ENSP00000385408  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 3): TNFRSF19
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    Novus Biologicals TNFRSF19 Proteins
    Novus Biologicals TNFRSF19 Lysates
    Sino Biological Recombinant Protein for TNFRSF19
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TNFRSF19

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane NAS10809768


    TNFRSF19 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TNFRSF19

    Protein Domains /
    Families
    for TNFRSF19 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TNFRSF19 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR022342 TNFR_19

    Graphical View of Domain Structure for InterPro Entry Q9NS68

    ProtoNet protein and cluster: Q9NS68

    1 Blocks protein family: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNR19_HUMAN, Q9NS68
    Similarity: Contains 3 TNFR-Cys repeats


    Function
    for TNFRSF19 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TNR19_HUMAN, Q9NS68
    Function: Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death

    miRNA
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    hsa-miR-548j hsa-miR-330-5p hsa-miR-548k hsa-miR-3616-5p hsa-miR-218-1* hsa-miR-578 hsa-miR-766 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): TNFRSF19 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFRSF19 (see all 7)
    OriGene shRNA RFP: TNFRSF19
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    Gene Editing
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    Clone
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    Cell Line
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    LifeMap BioReagents: cell line associated with TNFRSF19: PureStem 7PEND24, NCr-fac & Meso-prx Progenitor

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005031tumor necrosis factor-activated receptor activity NAS10809768


    TNFRSF19 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TNFRSF19:
     Increased cell number in G1, s 

    Animal Models:
         Mouse knock-out Tnfrsf19tm1Shmi for TNFRSF19
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tnfrsf19):
     cardiovascular system  craniofacial  endocrine/exocrine gland  homeostasis/metabolism  integument 
     nervous system  reproductive system 

    TNFRSF19 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TNFRSF19 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF Pathway
    		TNF Superfamily Pathway0.42
    		TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.08
    2PEDF Induced Signaling
    		Cytokine-cytokine receptor interaction0.26

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for TNFRSF19
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TNFRSF19
        TNF Superfamily Pathway


    1         Kegg Pathway  (Kegg details for TNFRSF19):
        Cytokine-cytokine receptor interaction


    TNFRSF19 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF19

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for TNFRSF19 (Q9NS683 ENSP000003716934) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF5O004633, ENSP000002614644I2D: score=2 STRING: ENSP00000261464
    TRAF1Q130773, ENSP000003629944I2D: score=2 STRING: ENSP00000362994
    TRAF2Q129333, ENSP000002476684I2D: score=2 STRING: ENSP00000247668
    TRAF3Q131143, ENSP000003324684I2D: score=1 STRING: ENSP00000332468
    TRAF6Q9Y4K33I2D: score=3 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001942hair follicle development IEA--
    GO:0006915apoptotic process IEA--
    GO:0006917induction of apoptosis NAS10809768
    GO:0007254JNK cascade NAS10809768
    GO:0033209tumor necrosis factor-mediated signaling pathway NAS10809768


    TNFRSF19 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TNFRSF19 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFRSF19
    Search CenterWatch for drugs/clinical trials and news about TNFRSF19 / TNR19 

    Transcripts
    for TNFRSF19 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TNFRSF19 gene (4 alternative transcripts): 
    NM_001204458.1  NM_001204459.1  NM_018647.3  NM_148957.3  

    Unigene Cluster for TNFRSF19:

    Tumor necrosis factor receptor superfamily, member 19
    Hs.149168  [show with all ESTs]
    Unigene Representative Sequence: NM_148957
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248484 ENST00000464735(uc001uou.3) ENST00000382258(uc001uov.2)
    ENST00000382263(uc001uot.3 uc010tcu.2 uc001uow.3) ENST00000403372


    miRNA
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    hsa-miR-548j hsa-miR-330-5p hsa-miR-548k hsa-miR-3616-5p hsa-miR-218-1* hsa-miR-578 hsa-miR-766 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): TNFRSF19 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFRSF19 (see all 7)
    OriGene shRNA RFP: TNFRSF19
    OriGene siRNA: TNFRSF19
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFRSF19
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF19
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF19

    Additional cDNA sequence: 

    AB040434.1 AF086276.1 AF167555.1 AF246998.1 AF246999.1 AK292874.1 AK292891.1 AK304290.1 
    AY358888.1 BC035796.1 BC047321.1 

    10 DOTS entries:

    DT.428579  DT.97829284  DT.212397  DT.40118607  DT.120762477  DT.97820899  DT.100016231  DT.120762447 
    DT.120762456  DT.120762457 

    24/115 AceView cDNA sequences (see all 115):

    BM564417 AA025737 BM555827 BU153396 AB040434 BM556223 AL120773 BE765875 
    BF971156 BE765901 BF507719 NM_018647 NM_148957 AI091645 BM474863 BF793201 
    AL036001 CA420904 BC047321 BF968836 AA464800 AI873370 BE855469 BF432648 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF19 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b
    SP1:                                -                 -                                               -               
    SP2:        -     -     -     -     -                 -                                               -               
    SP3:                                                  -                                                               
    SP4:                                                                                                                  
    SP5:                                -     -     -     -                 -     -                                       


    ECgene alternative splicing isoforms for TNFRSF19

    Expression
    for TNFRSF19 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFRSF19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATTTTCTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TNFRSF19 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    Paraxial MesodermParaxial MesodermParaxial Mesoderm CellsMesoderm
    LungStem BronchiProximal Lung Epithelial CellsLung
    BrainCerebral CortexBrain
    KidneyUreteric BudKidney
    LungLung MesodermLung
    LungStem BronchiLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

    See TNFRSF19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFRSF19

    SOURCE GeneReport for Unigene cluster: Hs.149168

    UniProtKB/Swiss-Prot: TNR19_HUMAN, Q9NS68
    Tissue specificity: Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small
    intestine, colon and peripheral blood leukocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF19: 
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              Polycomb & Trithorax Target Genes in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for TNFRSF19 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF19 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TNFRSF191 tumor necrosis factor receptor superfamily, member more 69.74(n)
    66.41(a)    		   418943  NM_001080103.1  NP_001073572.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TNFRSF196
    		 --
    		 78(a)
    		 1 ↔ 1
    		 3(188730232-188763977)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa04d102 wufa04d10 85.09(n)   334820  AA495217.1 


    ENSEMBL Gene Tree for TNFRSF19 (if available)
    TreeFam Gene Tree for TNFRSF19 (if available) 

    Paralogs
    for TNFRSF19 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFRSF19 gene
    EDAR2  EDA2R2  
    1 SIMAP similar gene for TNFRSF19 using alignment to 1 protein entry:     TNR19_HUMAN:
    EDA2R

    TNFRSF19 for paralogs           About GeneDecksing



    Genomic Variants
    for TNFRSF19 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1939 NCBI SNPs in TNFRSF19 are shown (see all 1939)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs761455591,2
    		--24142677(+) GAACTA/GCAAAG 2 -- us2k12Minor allele frequency- G:0.04CSA WA 120
    rs1831129841,2
    		--24142789(+) AACCCA/GAATTC 2 -- us2k10--------
    rs1150965831,2
    		C,F,--24142860(+) GCCAAT/CGAGCC 2 -- us2k11Minor allele frequency- C:0.06WA 118
    rs758674561,2
    		--24142873(+) ACAGAA/GTGTCT 2 -- us2k10--------
    rs95530011,2
    		C,F,A,H,--24143006(+) CTTCTT/GGTAAA 2 -- us2k1 tfbs314Minor allele frequency- G:0.16NS EA NA WA 1188
    rs1861731051,2
    		--24143020(+) TTTGTC/TTTTGT 2 -- us2k10--------
    rs1162966641,2
    		--24143136(+) CACACC/TTGCCA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1920735581,2
    		--24143218(+) TGGAAA/GAATCA 2 -- us2k10--------
    rs1836332021,2
    		--24143242(+) AATGTG/TATACA 2 -- us2k10--------
    rs777648121,2
    		F,--24143336(+) ATAACG/ATTTTC 2 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for TNFRSF19 (24144509 - 24250232 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for TNFRSF19
         3 CNVs: 4899 5317 9216

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    Disorders / Diseases
    for TNFRSF19 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TNFRSF19 for disorders           About GeneDecksing

    OMIM gene information: 606122    OMIM disorders: --

    13 diseases for TNFRSF19:    About MalaCards
    crimean-congo hemorrhagic fever    hypohidrotic ectodermal dysplasia    ectodermal dysplasia    hemorrhagic fever
    vascular dementia    multiple sclerosis    dementia    hepatitis b
    nasopharyngitis    glioblastoma    hepatitis    melanoma
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for TNFRSF19:
    Crimean-Congo hemorrhagic fever
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF19 (4 documents)

    Export disorders for TNFRSF19 gene to outside databases

    Publications
    for TNFRSF19 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFRSF19 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with TNFRSF19)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles. (PubMed id 10764796)1, 2, 3, 9 Kojima T.... Kitamura T. (2000)
    2. TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase- independent cell death. (PubMed id 10809768)1, 2, 3 Eby M.T.... Chaudhary P.M. (2000)
    3. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. (PubMed id 15694321)1, 2, 9 Park J.B....He Z. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Novel associations for hypothyroidism include known au toimmune risk loci. (PubMed id 22493691)1 Eriksson N....Do C.B. (2012)
    8. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    9. Tumor necrosis factor-receptor 2 and TROY gene express ion patterns in cutaneous squamous cell carcinoma in a Tunisian population. (PubMed id 22057614)1 Zidi I.T....Nouira R.B. (2011)
    10. A strong synergistic epistasis between FAM134B and TN FRSF19 on the susceptibility to vascular dementia. (PubMed id 21127458)1 Kong M....Lee C. (2011)

    External Searches for TNFRSF19 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TNFRSF19 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55504 HGNC: 11915 AceView: TNFRSF19 Ensembl:ENSG00000127863 euGenes: HUgn55504
    ECgene: TNFRSF19 Kegg: 55504 H-InvDB: TNFRSF19

    Other Databases showing TNFRSF19 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TNFRSF19 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFRSF19 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF19 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TNFRSF19 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TNFRSF19 gene:
    Search GeneIP for patents involving TNFRSF19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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