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Aliases for TNFRSF19 Gene

Aliases for TNFRSF19 Gene

  • TNF Receptor Superfamily Member 19 2 3 5
  • Toxicity And JNK Inducer 2 3 4
  • TRADE 3 4
  • TROY 3 4
  • TAJ 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 19 2
  • Tumor Necrosis Factor Receptor Superfamily Member 19 3
  • TAJ-Alpha 3

External Ids for TNFRSF19 Gene

Previous GeneCards Identifiers for TNFRSF19 Gene

  • GC13P022133
  • GC13P018133
  • GC13P023074
  • GC13P021942
  • GC13P023042
  • GC13P024144
  • GC13P004956

Summaries for TNFRSF19 Gene

Entrez Gene Summary for TNFRSF19 Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF19 Gene

TNFRSF19 (TNF Receptor Superfamily Member 19) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions. GO annotations related to this gene include tumor necrosis factor-activated receptor activity. An important paralog of this gene is EDA2R.

UniProtKB/Swiss-Prot for TNFRSF19 Gene

  • Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.

Gene Wiki entry for TNFRSF19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF19 Gene

Genomics for TNFRSF19 Gene

Regulatory Elements for TNFRSF19 Gene

Enhancers for TNFRSF19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F023629 1.2 Ensembl ENCODE 19.7 +59.6 59627 1.7 ELF3 MLX ARID4B FEZF1 DMAP1 ZSCAN9 RAD21 RARA ZNF121 GATA4 TNFRSF19 LOC105370114
GH13F023637 1.1 Ensembl ENCODE 18 +67.9 67931 1.0 ELF3 SOX13 SAP130 ZNF644 RAD21 YY1 RARA POLR2A HNF4G NR2F6 TNFRSF19 LOC105370114
GH13F023616 0.9 Ensembl ENCODE 20 +48.0 47997 3.2 ARID1B RFX1 JUND TAL1 JUN HLF FOS ZIC2 TNFRSF19 LOC105370114
GH13F023614 0.9 ENCODE 19.9 +45.3 45349 1.8 ELF3 ATF1 MLX ARID4B ZNF48 RAD21 RARA CREM MIXL1 THAP11 TNFRSF19 LOC105370114
GH13F023655 1.1 Ensembl ENCODE 16.1 +87.2 87163 3.2 HDAC1 FEZF1 RAD21 RARA ZNF121 EGR1 SCRT2 FOS ETV6 CREM TNFRSF19 LOC105370114
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFRSF19 on UCSC Golden Path with GeneCards custom track

Promoters for TNFRSF19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000512888 1730 3000 ELF3 TBP MLX ARID4B RAD21 ZBTB40 RARA YY1 SLC30A9 GATA4

Transcription factor binding sites by QIAGEN in the TNFRSF19 gene promoter:

Genomic Location for TNFRSF19 Gene

Chromosome:
13
Start:
23,570,370 bp from pter
End:
23,676,105 bp from pter
Size:
105,736 bases
Orientation:
Plus strand

Genomic View for TNFRSF19 Gene

Genes around TNFRSF19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF19 Gene

Proteins for TNFRSF19 Gene

  • Protein details for TNFRSF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS68-TNR19_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 19
    Protein Accession:
    Q9NS68
    Secondary Accessions:
    • A8KA09
    • A8KA26
    • B1AM40
    • B1AM41
    • B4E2I6
    • Q9BXZ9
    • Q9BY00
    • Q9NZV2

    Protein attributes for TNFRSF19 Gene

    Size:
    423 amino acids
    Molecular mass:
    46015 Da
    Quaternary structure:
    • Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.

    Alternative splice isoforms for TNFRSF19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFRSF19 Gene

Post-translational modifications for TNFRSF19 Gene

  • Glycosylation at Asn 105
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for TNFRSF19 (TROY/TNFRSF19)
  • Abcam antibodies for TNFRSF19
  • Cloud-Clone Corp. Antibodies for TNFRSF19

Protein Products

  • Enzo Life Sciences proteins for TNFRSF19
  • Cloud-Clone Corp. Proteins for TNFRSF19
  • Abcam proteins for TNFRSF19

No data available for DME Specific Peptides for TNFRSF19 Gene

Domains & Families for TNFRSF19 Gene

Gene Families for TNFRSF19 Gene

Protein Domains for TNFRSF19 Gene

Suggested Antigen Peptide Sequences for TNFRSF19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS68

UniProtKB/Swiss-Prot:

TNR19_HUMAN :
  • Contains 3 TNFR-Cys repeats.
Similarity:
  • Contains 3 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF19: view

Function for TNFRSF19 Gene

Molecular function for TNFRSF19 Gene

UniProtKB/Swiss-Prot Function:
Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.

Gene Ontology (GO) - Molecular Function for TNFRSF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005031 tumor necrosis factor-activated receptor activity NAS 10809768
genes like me logo Genes that share ontologies with TNFRSF19: view
genes like me logo Genes that share phenotypes with TNFRSF19: view

Animal Models for TNFRSF19 Gene

MGI Knock Outs for TNFRSF19:

Animal Model Products

  • Taconic Biosciences Mouse Models for TNFRSF19

miRNA for TNFRSF19 Gene

miRTarBase miRNAs that target TNFRSF19

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF19 Gene

Localization for TNFRSF19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF19 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF19 gene
Compartment Confidence
plasma membrane 5
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for TNFRSF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 10809768
genes like me logo Genes that share ontologies with TNFRSF19: view

Pathways & Interactions for TNFRSF19 Gene

genes like me logo Genes that share pathways with TNFRSF19: view

Pathways by source for TNFRSF19 Gene

Gene Ontology (GO) - Biological Process for TNFRSF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development IEA --
GO:0006915 apoptotic process NAS 10809768
GO:0007254 JNK cascade NAS 10809768
GO:0009888 tissue development IBA --
GO:0033209 tumor necrosis factor-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with TNFRSF19: view

No data available for SIGNOR curated interactions for TNFRSF19 Gene

Transcripts for TNFRSF19 Gene

Unigene Clusters for TNFRSF19 Gene

Tumor necrosis factor receptor superfamily, member 19:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF19 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b
SP1: - - -
SP2: - - - - - - -
SP3: -
SP4:
SP5: - - - - - -
SP6: -

Relevant External Links for TNFRSF19 Gene

GeneLoc Exon Structure for
TNFRSF19
ECgene alternative splicing isoforms for
TNFRSF19

Expression for TNFRSF19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFRSF19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF19 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x7.8), Skin - Sun Exposed (Lower leg) (x6.9), and Heart - Atrial Appendage (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF19 Gene



NURSA nuclear receptor signaling pathways regulating expression of TNFRSF19 Gene:

TNFRSF19

SOURCE GeneReport for Unigene cluster for TNFRSF19 Gene:

Hs.149168

mRNA Expression by UniProt/SwissProt for TNFRSF19 Gene:

Q9NS68-TNR19_HUMAN
Tissue specificity: Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with TNFRSF19: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for TNFRSF19 Gene

Orthologs for TNFRSF19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF19 34 35
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia TNFRSF19 34 35
  • 84.18 (n)
rat
(Rattus norvegicus)
Mammalia Tnfrsf19 34
  • 77.1 (n)
mouse
(Mus musculus)
Mammalia Tnfrsf19 34 16 35
  • 76.29 (n)
cow
(Bos Taurus)
Mammalia TNFRSF19 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFRSF19 35
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNFRSF19 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNFRSF19 34 35
  • 69.74 (n)
lizard
(Anolis carolinensis)
Reptilia TNFRSF19 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfrsf19 34
  • 66.37 (n)
zebrafish
(Danio rerio)
Actinopterygii tnfrsf19 34 35
  • 62.4 (n)
wufa04d10 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2275 35
  • 24 (a)
OneToMany
Species where no ortholog for TNFRSF19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF19 Gene

ENSEMBL:
Gene Tree for TNFRSF19 (if available)
TreeFam:
Gene Tree for TNFRSF19 (if available)

Paralogs for TNFRSF19 Gene

Paralogs for TNFRSF19 Gene

(1) SIMAP similar genes for TNFRSF19 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNFRSF19: view

Variants for TNFRSF19 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF19 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1034068 -- 23,656,672(+) TTTGA(C/G)CAAAA intron-variant, nc-transcript-variant
rs10454654 -- 23,657,701(+) ttctt(C/T)ttttt intron-variant, nc-transcript-variant
rs10595406 -- 23,633,530(+) GCAAA(-/CTC)CTCAT intron-variant
rs10609624 -- 23,586,176(+) TGGTG(-/TG)AACCT intron-variant
rs10615843 -- 23,644,843(+) TATAT(-/AT)ATTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF19 Gene

Variant ID Type Subtype PubMed ID
nsv974235 CNV duplication 23825009
nsv962 CNV deletion 18451855
nsv832565 CNV gain 17160897
nsv561292 CNV loss 21841781
nsv525965 CNV gain 19592680
nsv455837 CNV gain 19166990
nsv1151909 OTHER inversion 26484159
nsv1140246 OTHER inversion 24896259
nsv1078303 OTHER inversion 25765185
nsv1041095 CNV loss 25217958
esv5325 OTHER complex 18987735
esv3892320 CNV loss 25118596
esv3892319 CNV gain 25118596
esv3892311 CNV gain 25118596
esv3631529 CNV gain 21293372
esv3631528 CNV loss 21293372
esv3631523 CNV gain 21293372
esv3580576 CNV loss 25503493
esv3580574 CNV loss 25503493
esv2751136 CNV loss 17911159
esv2422502 CNV duplication 17116639
dgv3084n54 CNV gain 21841781
dgv1615n100 CNV gain 25217958

Variation tolerance for TNFRSF19 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.56; 86.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF19 Gene

Disorders for TNFRSF19 Gene

Relevant External Links for TNFRSF19

Genetic Association Database (GAD)
TNFRSF19
Human Genome Epidemiology (HuGE) Navigator
TNFRSF19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFRSF19

No disorders were found for TNFRSF19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFRSF19 Gene

Publications for TNFRSF19 Gene

  1. TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles. (PMID: 10764796) Kojima T. … Kitamura T. (J. Biol. Chem. 2000) 2 3 4 22 64
  2. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. (PMID: 15694321) Park J.B. … He Z. (Neuron 2005) 3 4 22 64
  3. TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase- independent cell death. (PMID: 10809768) Eby M.T. … Chaudhary P.M. (J. Biol. Chem. 2000) 2 3 4 64
  4. A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. (PMID: 20512145) Bei J.X. … Zeng Y.X. (Nat. Genet. 2010) 3 46 64
  5. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PMID: 15301860) Cho S.M. … Lee J.K. (Hum. Immunol. 2004) 3 46 64

Products for TNFRSF19 Gene

Sources for TNFRSF19 Gene

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