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Aliases for TNFRSF19 Gene

Aliases for TNFRSF19 Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 19 2 3
  • Toxicity And JNK Inducer 2 3 4
  • TROY 3 4 6
  • TAJ 3 4 6
  • TRADE 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 19 3
  • TAJ-Alpha 3

External Ids for TNFRSF19 Gene

Summaries for TNFRSF19 Gene

Entrez Gene Summary for TNFRSF19 Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF19 Gene

TNFRSF19 (Tumor Necrosis Factor Receptor Superfamily, Member 19) is a Protein Coding gene. Among its related pathways are TNF Signaling and TNF Signaling. GO annotations related to this gene include tumor necrosis factor-activated receptor activity.

UniProtKB/Swiss-Prot for TNFRSF19 Gene

  • Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death

Gene Wiki entry for TNFRSF19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF19 Gene

Genomics for TNFRSF19 Gene

Genomic Location for TNFRSF19 Gene

Start:
23,570,370 bp from pter
End:
23,676,105 bp from pter
Size:
105,736 bases
Orientation:
Plus strand

Genomic View for TNFRSF19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF19 Gene

Regulatory Elements for TNFRSF19 Gene

Transcription factor binding sites by QIAGEN in the TNFRSF19 gene promoter:

Proteins for TNFRSF19 Gene

  • Protein details for TNFRSF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS68-TNR19_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 19
    Protein Accession:
    Q9NS68
    Secondary Accessions:
    • A8KA09
    • A8KA26
    • B1AM40
    • B1AM41
    • B4E2I6
    • Q9BXZ9
    • Q9BY00
    • Q9NZV2

    Protein attributes for TNFRSF19 Gene

    Size:
    423 amino acids
    Molecular mass:
    46015 Da
    Quaternary structure:
    • Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.

    Alternative splice isoforms for TNFRSF19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFRSF19 Gene

Proteomics data for TNFRSF19 Gene at MOPED

Post-translational modifications for TNFRSF19 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn105

Other Protein References for TNFRSF19 Gene

No data available for DME Specific Peptides for TNFRSF19 Gene

Domains for TNFRSF19 Gene

Gene Families for TNFRSF19 Gene

HGNC:
  • TNFRSF :Tumor necrosis factor receptor superfamily
IUPHAR :

Protein Domains for TNFRSF19 Gene

UniProtKB/Swiss-Prot:

TNR19_HUMAN
Similarity:
  • Contains 3 TNFR-Cys repeats.:
    • Q9NS68
genes like me logo Genes that share domains with TNFRSF19: view

Function for TNFRSF19 Gene

Molecular function for TNFRSF19 Gene

UniProtKB/Swiss-Prot Function: Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death

Gene Ontology (GO) - Molecular Function for TNFRSF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005031 tumor necrosis factor-activated receptor activity NAS 10809768
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TNFRSF19: view
genes like me logo Genes that share phenotypes with TNFRSF19: view

Animal Models for TNFRSF19 Gene

MGI Knock Outs for TNFRSF19:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TNFRSF19 Gene

Localization for TNFRSF19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF19 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFRSF19 Gene COMPARTMENTS Subcellular localization image for TNFRSF19 gene
Compartment Confidence
extracellular 3
plasma membrane 3
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TNFRSF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane NAS 10809768
genes like me logo Genes that share ontologies with TNFRSF19: view

Pathways for TNFRSF19 Gene

genes like me logo Genes that share pathways with TNFRSF19: view

Pathways by source for TNFRSF19 Gene

1 Qiagen pathway for TNFRSF19 Gene
1 KEGG pathway for TNFRSF19 Gene

Gene Ontology (GO) - Biological Process for TNFRSF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development IEA --
GO:0006915 apoptotic process NAS 10809768
GO:0007254 JNK cascade NAS 10809768
GO:0033209 tumor necrosis factor-mediated signaling pathway NAS 10809768
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA --
genes like me logo Genes that share ontologies with TNFRSF19: view

Compounds for TNFRSF19 Gene

(6) ApexBio Compounds for TNFRSF19 Gene

Compound Action Cas Number
AS 602801 novel, orally active, Jun Kinase Inhibitor [848344-36-5]
CC-401 hydrochloride second generation ATP-competitive anthrapyrazolone JNK inhibitor [1438391-30-0]
CC-930 selective JNK inhibitor [899805-25-5]
JNK-IN-7 relatively selective JNK inhibitor. [1408064-71-0]
JNK-IN-8 highly selective JNK inhibitor [1410880-22-6]
SP 600125 Selective, reversible, and ATP-competitive JNK1/2/3 inhibitor [129-56-6]
genes like me logo Genes that share compounds with TNFRSF19: view

Transcripts for TNFRSF19 Gene

Unigene Clusters for TNFRSF19 Gene

Tumor necrosis factor receptor superfamily, member 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF19 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b
SP1: - - -
SP2: - - - - - - -
SP3: -
SP4:
SP5: - - - - - -
SP6: -

Relevant External Links for TNFRSF19 Gene

GeneLoc Exon Structure for
TNFRSF19
ECgene alternative splicing isoforms for
TNFRSF19

Expression for TNFRSF19 Gene

mRNA expression in normal human tissues for TNFRSF19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF19 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (7.8), Skin - Sun Exposed (Lower leg) (6.9), and Heart - Atrial Appendage (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNFRSF19 Gene

SOURCE GeneReport for Unigene cluster for TNFRSF19 Gene Hs.149168

mRNA Expression by UniProt/SwissProt for TNFRSF19 Gene

Q9NS68-TNR19_HUMAN
Tissue specificity: Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes
genes like me logo Genes that share expressions with TNFRSF19: view

Orthologs for TNFRSF19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF19 36
  • 99.13 (n)
  • 99.05 (a)
TNFRSF19 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNFRSF19 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNFRSF19 36
  • 84.18 (n)
  • 79.9 (a)
TNFRSF19 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnfrsf19 36
  • 76.29 (n)
  • 71.36 (a)
Tnfrsf19 16
Tnfrsf19 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNFRSF19 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFRSF19 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfrsf19 36
  • 77.1 (n)
  • 73.79 (a)
chicken
(Gallus gallus)
Aves TNFRSF19 36
  • 69.74 (n)
  • 66.41 (a)
TNFRSF19 37
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFRSF19 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfrsf19 36
  • 66.37 (n)
  • 64.48 (a)
zebrafish
(Danio rerio)
Actinopterygii tnfrsf19 36
  • 62.4 (n)
  • 58.92 (a)
tnfrsf19 37
  • 50 (a)
OneToOne
wufa04d10 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2275 37
  • 24 (a)
OneToMany
Species with no ortholog for TNFRSF19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF19 Gene

ENSEMBL:
Gene Tree for TNFRSF19 (if available)
TreeFam:
Gene Tree for TNFRSF19 (if available)

Paralogs for TNFRSF19 Gene

Selected SIMAP similar genes for TNFRSF19 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNFRSF19: view

No data available for Paralogs for TNFRSF19 Gene

Variants for TNFRSF19 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF19 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1630 -- 23,675,708(-) CCGAC(A/G)CAGCC utr-variant-3-prime
rs735901 -- 23,671,338(+) TACTA(A/G)CTTTT intron-variant
rs765606 -- 23,589,200(-) AAAAG(C/T)GAAGC intron-variant
rs880624 -- 23,588,238(+) CTTAT(C/T)CCAGG intron-variant
rs913561 -- 23,669,582(+) CACTC(C/T)GCTTT intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF19 Gene

Variant ID Type Subtype PubMed ID
esv2422502 CNV Duplication 17116639
esv2747122 CNV Deletion 23290073
esv5325 CNV Complex 18987735
nsv455837 CNV Gain 19166990
nsv525965 CNV Gain 19592680
dgv1561n71 CNV Gain 21882294
esv2751136 CNV Loss 17911159
nsv899919 CNV Gain 21882294
nsv899921 CNV Loss 21882294
nsv832565 CNV Gain 17160897
nsv899923 CNV Gain 21882294
nsv899924 CNV Gain 21882294
dgv1565n71 CNV Gain 21882294
nsv962 CNV Loss 18451855

Relevant External Links for TNFRSF19 Gene

HapMap Linkage Disequilibrium report
TNFRSF19

Disorders for TNFRSF19 Gene

(1) University of Copenhagen DISEASES for TNFRSF19 Gene

Relevant External Links for TNFRSF19

Genetic Association Database (GAD)
TNFRSF19
Human Genome Epidemiology (HuGE) Navigator
TNFRSF19
genes like me logo Genes that share disorders with TNFRSF19: view

No data available for UniProtKB/Swiss-Prot for TNFRSF19 Gene

Publications for TNFRSF19 Gene

  1. TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles. (PMID: 10764796) Kojima T. … Kitamura T. (J. Biol. Chem. 2000) 2 3 4 23
  2. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. (PMID: 15694321) Park J.B. … He Z. (Neuron 2005) 3 4 23
  3. TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase- independent cell death. (PMID: 10809768) Eby M.T. … Chaudhary P.M. (J. Biol. Chem. 2000) 2 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PMID: 15301860) Cho S.M. … Lee J.K. (Hum. Immunol. 2004) 3 49

Products for TNFRSF19 Gene

Sources for TNFRSF19 Gene

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