Aliases for TNFRSF19 Gene
External Ids for TNFRSF19 Gene
Previous GeneCards Identifiers for TNFRSF19 Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF19 Gene
TNFRSF19 (Tumor Necrosis Factor Receptor Superfamily Member 19) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways. GO annotations related to this gene include tumor necrosis factor-activated receptor activity. An important paralog of this gene is EDA2R.
UniProtKB/Swiss-Prot for TNFRSF19 Gene
Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.