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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF19 Gene

protein-coding   GIFtS: 64
GCID: GC13P024144

Tumor Necrosis Factor Receptor Superfamily, Member 19

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 191 2     TRADE2 3
Toxicity And JNK Inducer1 2 3     TAJ-alpha2
TAJ2 3 5     Tumor Necrosis Factor Receptor Superfamily Member 192
TROY2 3 5     

External Ids:    HGNC: 119151   Entrez Gene: 555042   Ensembl: ENSG000001278637   OMIM: 6061225   UniProtKB: Q9NS683   

Export aliases for TNFRSF19 gene to outside databases

Previous GC identifers: GC13P022133 GC13P018133 GC13P023074 GC13P021942 GC13P023042 GC13P004956


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF19 Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed
during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK
signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a
caspase-independent mechanism, and it is thought to play an essential role in embryonic development.
Alternatively spliced transcript variants encoding distinct isoforms have been described. (provided by RefSeq,
Jul 2008)

GeneCards Summary for TNFRSF19 Gene: 
TNFRSF19 (tumor necrosis factor receptor superfamily, member 19) is a protein-coding gene. Diseases associated with TNFRSF19 include hypohidrotic ectodermal dysplasia, and crimean-congo hemorrhagic fever, and among its related super-pathways are TNF Signaling and STAT3 Pathway. GO annotations related to this gene include tumor necrosis factor-activated receptor activity. An important paralog of this gene is EDA2R.

UniProtKB/Swiss-Prot: TNR19_HUMAN, Q9NS68
Function: Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death

Gene Wiki entry for TNFRSF19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF19 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF19 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.11-q12.3   Ensembl cytogenetic band:  13q12.12   HGNC cytogenetic band: 13q12.11-q12.3

TNFRSF19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF19 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P024144:  view genomic region     (about GC identifiers)

Start:
24,144,509 bp from pter      End:
24,250,244 bp from pter
Size:
105,736 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNR19_HUMAN, Q9NS68 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 19 precursor  
Size: 423 amino acids; 46015 Da
Subunit: Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1
Subcellular location: Membrane; Single-pass type I membrane protein (Probable)
Secondary accessions: B1AM40 B1AM41 B4E2I6 Q9BXZ9 Q9BY00 Q9NZV2
Alternative splicing: 3 isoforms:  Q9NS68-1   Q9NS68-2   Q9NS68-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNFRSF19: NX_Q9NS68

Explore proteomics data for TNFRSF19 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NS68

  • TNFRSF19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNFRSF19 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001191387.1  NP_001191388.1  NP_061117.2  NP_683760.1  

    ENSEMBL proteins: 
     ENSP00000248484   ENSP00000371693   ENSP00000371698   ENSP00000385408  

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    Cloud-Clone Corp. Proteins for TNFRSF19 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane NAS10809768

    TNFRSF19 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: toxicity and JNK inducer 
    Tumour necrosis factor (TNF) receptor family

    2 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR022342 TNFR_19

    Graphical View of Domain Structure for InterPro Entry Q9NS68

    ProtoNet protein and cluster: Q9NS68

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNR19_HUMAN, Q9NS68
    Similarity: Contains 3 TNFR-Cys repeats


    TNFRSF19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR19_HUMAN, Q9NS68
    Function: Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005031tumor necrosis factor-activated receptor activity NAS10809768
    GO:0005515protein binding ----
         
    TNFRSF19 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TNFRSF19:
     Increased cell number in G1, s 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tnfrsf19):
     cardiovascular system  craniofacial  endocrine/exocrine gland  homeostasis/metabolism  integument 
     nervous system  reproductive system 

    TNFRSF19 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tnfrsf19tm1Shmi for TNFRSF19

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNFRSF19 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    3TRAF Pathway
    TNF Superfamily Pathway0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFRSF19
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TNFRSF19
        TNF Superfamily Pathway

    3 Sino Biological Pathways for TNFRSF19 
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1         Kegg Pathway  (Kegg details for TNFRSF19):
        Cytokine-cytokine receptor interaction


    TNFRSF19 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF19

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for TNFRSF19 (Q9NS683 ENSP000003716934) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF5O004633, ENSP000002614644I2D: score=2 STRING: ENSP00000261464
    TRAF1Q130773, ENSP000003629944I2D: score=2 STRING: ENSP00000362994
    TRAF2Q129333, ENSP000002476684I2D: score=2 STRING: ENSP00000247668
    TRAF3Q131143, ENSP000003324684I2D: score=1 STRING: ENSP00000332468
    TRAF6Q9Y4K33I2D: score=3 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001942hair follicle development IEA--
    GO:0006915apoptotic process NAS10809768
    GO:0007254JNK cascade NAS10809768
    GO:0033209tumor necrosis factor-mediated signaling pathway NAS10809768
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade RCA19641626

    TNFRSF19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFRSF19 (TNR19)

    Search CenterWatch for drugs/clinical trials and news about TNFRSF19 / TNR19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNFRSF19 gene (4 alternative transcripts): 
    NM_001204458.1  NM_001204459.1  NM_018647.3  NM_148957.3  

    Unigene Cluster for TNFRSF19:

    Tumor necrosis factor receptor superfamily, member 19
    Hs.149168  [show with all ESTs]
    Unigene Representative Sequence: NM_148957
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248484 ENST00000464735(uc001uou.3) ENST00000382258(uc001uov.2)
    ENST00000382263(uc001uot.3 uc010tcu.2 uc001uow.3) ENST00000403372

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    Additional mRNA sequence: 

    AB040434.1 AF086276.1 AF167555.1 AF246998.1 AF246999.1 AK292874.1 AK292891.1 AK304290.1 
    AY358888.1 BC035796.1 BC047321.1 

    9 DOTS entries:

    DT.428579  DT.97829284  DT.212397  DT.40118607  DT.120762477  DT.97820899  DT.100016231  DT.120762456 
    DT.120762457 

    24/115 AceView cDNA sequences (see all 115):

    NM_018647 BE765875 BF971156 BF793201 BF968836 BC047321 AI091645 BE765901 
    AI873370 BF507719 BM474863 AA025737 AL036001 BM564417 BM555827 BU153396 
    AB040434 AL120773 BM556223 CA420904 AA464800 NM_148957 BM477887 AF246998 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF19 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b
    SP1:                                -                 -                                               -               
    SP2:        -     -     -     -     -                 -                                               -               
    SP3:                                                  -                                                               
    SP4:                                                                                                                  
    SP5:                                -     -     -     -                 -     -                                       


    ECgene alternative splicing isoforms for TNFRSF19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFRSF19 expression in normal human tissues (normalized intensities)      TNFRSF19 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTTCTAA
    TNFRSF19 Expression
    About this image


    TNFRSF19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Adult Endothelial Cells Blood Brain Barrier
             Thalamus
             N2/LSB/S/F8/CHIR-induced cells ( Generation of midbrain dopaminergic, forebrain and...
             brain/midbrain   
     
     Lung (Respiratory System)    fully expand to see all 6 entries
             Proximal Lung Epithelial Cells Stem Bronchi
             Stem Bronchi
             Human Pulmonary Fibroblasts (HPF)   
             trachea   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
             Human Nucleus Pulposus Cells (HNPC)   
             sensory organ/ear/external ear   
     
     Uncategorized (Uncategorized)    fully expand to see all 3 entries
             PureStem Progenitor EN7
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier

    See TNFRSF19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFRSF19

    SOURCE GeneReport for Unigene cluster: Hs.149168

    UniProtKB/Swiss-Prot: TNR19_HUMAN, Q9NS68
    Tissue specificity: Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus,
    small intestine, colon and peripheral blood leukocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF19: 
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              Polycomb & Trithorax Target Genes in human mouse rat
              Apoptosis 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF19 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf191 , 5 tumor necrosis factor receptor superfamily, member more1, 5 76.29(n)1
    71.36(a)1
      14 (32.06 cM)5
    298201  NM_001164155.11  NP_001157627.11 
     609638345 
    chicken
    (Gallus gallus)
    Aves TNFRSF191 tumor necrosis factor receptor superfamily, member more 69.74(n)
    66.41(a)
      418943  NM_001080103.1  NP_001073572.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNFRSF196
    Uncharacterized protein
    75(a)
    1 ↔ 1
    3(188730232-188764173)
    zebrafish
    (Danio rerio)
    Actinopterygii wufa04d102 wufa04d10 85.09(n)   334820  AA495217.1 


    ENSEMBL Gene Tree for TNFRSF19 (if available)
    TreeFam Gene Tree for TNFRSF19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFRSF19 gene
    EDA2R2  
    1 SIMAP similar gene for TNFRSF19 using alignment to 1 protein entry:     TNR19_HUMAN:
    EDA2R

    TNFRSF19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2228 SNPs in TNFRSF19 are shown (see all 2228)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476444431,2
    C--4959951(+) TCCAG-/TTTTTTT 2 -- int10--------
    rs669354691,2
    C--5195548(+) ATATA-/TATG  
            
    TATGT
    4 -- int10--------
    rs591820461,2
    C--5195550(+) TATAT-/GTATGTA 4 -- int11Minor allele frequency- GT:0.00NA 2
    rs761455591,2
    F--24142677(+) GAACTA/GCAAAG 2 -- us2k12Minor allele frequency- G:0.04CSA WA 120
    rs1831129841,2
    --24142789(+) AACCCA/GAATTC 2 -- us2k10--------
    rs1150965831,2
    C,F--24142860(+) GCCAAT/CGAGCC 2 -- us2k11Minor allele frequency- C:0.06WA 118
    rs758674561,2
    --24142873(+) ACAGAA/GTGTCT 2 -- us2k10--------
    rs95530011,2
    C,F,A,H--24143006(+) CTTCTT/GGTAAA 2 -- us2k1 tfbs314Minor allele frequency- G:0.16NS EA NA WA 1188
    rs1861731051,2
    --24143020(+) TTTGTC/TTTTGT 2 -- us2k10--------
    rs1162966641,2
    C,F--24143136(+) CACACC/TTGCCA 2 -- us2k11Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for TNFRSF19 (24144509 - 24250244 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for TNFRSF19 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2747122CNV Deletion23290073
    esv2422502CNV Duplication17116639
    nsv962CNV Loss18451855
    esv2751136CNV Loss17911159
    nsv899921CNV Loss21882294
    nsv899924CNV Gain21882294
    nsv832565CNV Gain17160897
    nsv525965CNV Gain19592680
    nsv899923CNV Gain21882294
    dgv1561n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606122    OMIM disorders: --

    15 diseases for TNFRSF19:    About MalaCards
    hypohidrotic ectodermal dysplasia    crimean-congo hemorrhagic fever    vascular dementia    ectodermal dysplasia
    hemorrhagic fever    dementia    hypothyroidism    nasopharyngitis
    multiple sclerosis    glioblastoma    hepatitis b    squamous cell carcinoma
    melanoma    hepatitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for TNFRSF19:
    Crimean-Congo hemorrhagic fever

    TNFRSF19 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TNFRSF19
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF19 (4 documents)

    Export disorders for TNFRSF19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFRSF19 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with TNFRSF19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles. (PubMed id 10764796)1, 2, 3, 9 Kojima T.... Kitamura T. (2000)
    2. TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase- independent cell death. (PubMed id 10809768)1, 2, 3 Eby M.T.... Chaudhary P.M. (2000)
    3. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. (PubMed id 15694321)1, 2, 9 Park J.B....He Z. (2005)
    4. A genome-wide association study of nasopharyngeal car cinoma identifies three new susceptibility loci. (PubMed id 20512145)1, 4 Bei J.X....Zeng Y.X. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PubMed id 15301860)1, 4 Cho S.M....Lee J.K. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells. (PubMed id 23142137)1 Fafilek B....Korinek V. (2013)
    10. Novel associations for hypothyroidism include known au toimmune risk loci. (PubMed id 22493691)1 Eriksson N....Do C.B. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55504 HGNC: 11915 AceView: TNFRSF19 Ensembl:ENSG00000127863 euGenes: HUgn55504
    ECgene: TNFRSF19 Kegg: 55504 H-InvDB: TNFRSF19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFRSF19 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF19 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNFRSF19 gene:
    Search GeneIP for patents involving TNFRSF19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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