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Aliases for TNFRSF19 Gene

Aliases for TNFRSF19 Gene

  • Tumor Necrosis Factor Receptor Superfamily Member 19 2 3 5
  • Toxicity And JNK Inducer 2 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 19 2 3
  • TRADE 3 4
  • TROY 3 4
  • TAJ 3 4
  • TAJ-Alpha 3

External Ids for TNFRSF19 Gene

Previous GeneCards Identifiers for TNFRSF19 Gene

  • GC13P022133
  • GC13P018133
  • GC13P023074
  • GC13P021942
  • GC13P023042
  • GC13P024144
  • GC13P004956

Summaries for TNFRSF19 Gene

Entrez Gene Summary for TNFRSF19 Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF19 Gene

TNFRSF19 (Tumor Necrosis Factor Receptor Superfamily Member 19) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways. GO annotations related to this gene include tumor necrosis factor-activated receptor activity. An important paralog of this gene is EDA2R.

UniProtKB/Swiss-Prot for TNFRSF19 Gene

  • Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.

Gene Wiki entry for TNFRSF19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF19 Gene

Genomics for TNFRSF19 Gene

Regulatory Elements for TNFRSF19 Gene

Promoters for TNFRSF19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNFRSF19 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TNFRSF19 gene promoter:

Genomic Location for TNFRSF19 Gene

Chromosome:
13
Start:
23,570,370 bp from pter
End:
23,676,105 bp from pter
Size:
105,736 bases
Orientation:
Plus strand

Genomic View for TNFRSF19 Gene

Genes around TNFRSF19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF19 Gene

Proteins for TNFRSF19 Gene

  • Protein details for TNFRSF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS68-TNR19_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 19
    Protein Accession:
    Q9NS68
    Secondary Accessions:
    • A8KA09
    • A8KA26
    • B1AM40
    • B1AM41
    • B4E2I6
    • Q9BXZ9
    • Q9BY00
    • Q9NZV2

    Protein attributes for TNFRSF19 Gene

    Size:
    423 amino acids
    Molecular mass:
    46015 Da
    Quaternary structure:
    • Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.

    Alternative splice isoforms for TNFRSF19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFRSF19 Gene

Proteomics data for TNFRSF19 Gene at MOPED

Post-translational modifications for TNFRSF19 Gene

  • Glycosylation at Asn 105
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF19 Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF19 (TROY/TNFRSF19)
  • Cloud-Clone Corp. Antibodies for TNFRSF19

Protein Products

  • Enzo Life Sciences proteins for TNFRSF19
  • Cloud-Clone Corp. Proteins for TNFRSF19

No data available for DME Specific Peptides for TNFRSF19 Gene

Domains & Families for TNFRSF19 Gene

Gene Families for TNFRSF19 Gene

Protein Domains for TNFRSF19 Gene

Suggested Antigen Peptide Sequences for TNFRSF19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS68

UniProtKB/Swiss-Prot:

TNR19_HUMAN :
  • Contains 3 TNFR-Cys repeats.
Similarity:
  • Contains 3 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF19: view

Function for TNFRSF19 Gene

Molecular function for TNFRSF19 Gene

UniProtKB/Swiss-Prot Function:
Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.

Gene Ontology (GO) - Molecular Function for TNFRSF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TNFRSF19: view
genes like me logo Genes that share phenotypes with TNFRSF19: view

Animal Models for TNFRSF19 Gene

MGI Knock Outs for TNFRSF19:

Animal Model Products

  • Taconic Biosciences Mouse Models for TNFRSF19

CRISPR Products

miRNA for TNFRSF19 Gene

miRTarBase miRNAs that target TNFRSF19

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF19 Gene

Localization for TNFRSF19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF19 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFRSF19 Gene COMPARTMENTS Subcellular localization image for TNFRSF19 gene
Compartment Confidence
extracellular 3
plasma membrane 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TNFRSF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 10809768
genes like me logo Genes that share ontologies with TNFRSF19: view

Pathways & Interactions for TNFRSF19 Gene

genes like me logo Genes that share pathways with TNFRSF19: view

Pathways by source for TNFRSF19 Gene

Gene Ontology (GO) - Biological Process for TNFRSF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process NAS 10809768
GO:0009888 tissue development IBA --
GO:0046330 positive regulation of JNK cascade IBA --
genes like me logo Genes that share ontologies with TNFRSF19: view

No data available for SIGNOR curated interactions for TNFRSF19 Gene

Drugs & Compounds for TNFRSF19 Gene

No Compound Related Data Available

Transcripts for TNFRSF19 Gene

Unigene Clusters for TNFRSF19 Gene

Tumor necrosis factor receptor superfamily, member 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF19 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b
SP1: - - -
SP2: - - - - - - -
SP3: -
SP4:
SP5: - - - - - -
SP6: -

Relevant External Links for TNFRSF19 Gene

GeneLoc Exon Structure for
TNFRSF19
ECgene alternative splicing isoforms for
TNFRSF19

Expression for TNFRSF19 Gene

mRNA expression in normal human tissues for TNFRSF19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF19 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x7.8), Skin - Sun Exposed (Lower leg) (x6.9), and Heart - Atrial Appendage (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF19 Gene



SOURCE GeneReport for Unigene cluster for TNFRSF19 Gene Hs.149168

mRNA Expression by UniProt/SwissProt for TNFRSF19 Gene

Q9NS68-TNR19_HUMAN
Tissue specificity: Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with TNFRSF19: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for TNFRSF19 Gene

Orthologs for TNFRSF19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF19 35
  • 99.13 (n)
  • 99.05 (a)
TNFRSF19 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNFRSF19 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNFRSF19 36
  • 80 (a)
OneToOne
TNFRSF19 35
  • 84.18 (n)
  • 79.9 (a)
mouse
(Mus musculus)
Mammalia Tnfrsf19 16
Tnfrsf19 35
  • 76.29 (n)
  • 71.36 (a)
Tnfrsf19 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNFRSF19 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFRSF19 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfrsf19 35
  • 77.1 (n)
  • 73.79 (a)
chicken
(Gallus gallus)
Aves TNFRSF19 35
  • 69.74 (n)
  • 66.41 (a)
TNFRSF19 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFRSF19 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfrsf19 35
  • 66.37 (n)
  • 64.48 (a)
zebrafish
(Danio rerio)
Actinopterygii tnfrsf19 36
  • 50 (a)
OneToOne
tnfrsf19 35
  • 62.4 (n)
  • 58.92 (a)
wufa04d10 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2275 36
  • 24 (a)
OneToMany
Species with no ortholog for TNFRSF19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF19 Gene

ENSEMBL:
Gene Tree for TNFRSF19 (if available)
TreeFam:
Gene Tree for TNFRSF19 (if available)

Paralogs for TNFRSF19 Gene

Paralogs for TNFRSF19 Gene

(1) SIMAP similar genes for TNFRSF19 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNFRSF19: view

Variants for TNFRSF19 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF19 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs9550987 - 23,593,366(+) GTGAA(A/T)CAGGA intron-variant, reference, missense
VAR_024279 -
rs61756242 - 23,659,080(+) GATCG(C/T)GTCCA reference, missense
rs932880 -- 23,613,900(-) TATTC(A/G)AGGAG intron-variant
rs1121114 -- 23,649,520(-) tggaa(A/G)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF19 Gene

Variant ID Type Subtype PubMed ID
esv2422502 CNV Duplication 17116639
esv2747122 CNV Deletion 23290073
esv5325 CNV Complex 18987735
nsv455837 CNV Gain 19166990
nsv525965 CNV Gain 19592680
dgv1561n71 CNV Gain 21882294
esv2751136 CNV Loss 17911159
nsv899919 CNV Gain 21882294
nsv899921 CNV Loss 21882294
nsv832565 CNV Gain 17160897
nsv899923 CNV Gain 21882294
nsv899924 CNV Gain 21882294
dgv1565n71 CNV Gain 21882294
nsv962 CNV Loss 18451855

Variation tolerance for TNFRSF19 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.56; 86.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF19 Gene

HapMap Linkage Disequilibrium report
TNFRSF19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF19 Gene

Disorders for TNFRSF19 Gene

Relevant External Links for TNFRSF19

Genetic Association Database (GAD)
TNFRSF19
Human Genome Epidemiology (HuGE) Navigator
TNFRSF19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFRSF19

No disorders were found for TNFRSF19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFRSF19 Gene

Publications for TNFRSF19 Gene

  1. TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles. (PMID: 10764796) Kojima T. … Kitamura T. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. (PMID: 15694321) Park J.B. … He Z. (Neuron 2005) 3 23
  3. TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase- independent cell death. (PMID: 10809768) Eby M.T. … Chaudhary P.M. (J. Biol. Chem. 2000) 2 3
  4. Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. (PMID: 25189868) Sung Y.J. … Rao D.C. (Am. J. Hypertens. 2015) 3
  5. I^-catenin regulates NF-I_B activity via TNFRSF19 in colorectal cancer cells. (PMID: 24623448) SchAPn S. … Herbst A. (Int. J. Cancer 2014) 3

Products for TNFRSF19 Gene

Sources for TNFRSF19 Gene

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