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Aliases for TNFRSF18 Gene

Aliases for TNFRSF18 Gene

  • TNF Receptor Superfamily Member 18 2 3 5
  • Glucocorticoid-Induced TNFR-Related Protein 3 4
  • Activation-Inducible TNFR Family Receptor 3 4
  • AITR 3 4
  • GITR 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 18 2
  • TNF Receptor Superfamily Activation-Inducible Protein 3
  • Tumor Necrosis Factor Receptor Superfamily Member 18 3
  • CD357 Antigen 4
  • GITR-D 3
  • CD357 3

External Ids for TNFRSF18 Gene

Previous GeneCards Identifiers for TNFRSF18 Gene

  • GC01M000665
  • GC01M000890
  • GC01M001015
  • GC01M001044
  • GC01M001179
  • GC01M001128
  • GC01M000410

Summaries for TNFRSF18 Gene

Entrez Gene Summary for TNFRSF18 Gene

  • This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]

GeneCards Summary for TNFRSF18 Gene

TNFRSF18 (TNF Receptor Superfamily Member 18) is a Protein Coding gene. Diseases associated with TNFRSF18 include Diverticulitis. Among its related pathways are TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions and Immune System. GO annotations related to this gene include tumor necrosis factor-activated receptor activity.

UniProtKB/Swiss-Prot for TNFRSF18 Gene

  • Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Gene Wiki entry for TNFRSF18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF18 Gene

Genomics for TNFRSF18 Gene

Regulatory Elements for TNFRSF18 Gene

Enhancers for TNFRSF18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F001196 1.7 FANTOM5 Ensembl ENCODE 8.8 +5.8 5847 8.0 ATF1 PKNOX1 GLIS2 ZNF143 FOS KLF13 ZNF202 NCOA1 REST CREB3 MIR6727 CCNL2 NOC2L ENSG00000230092 ENSG00000240731 LOC100288379 SLC35E2 CICP3 ATAD3A LOC100129381
GH01F001204 1.7 FANTOM5 Ensembl ENCODE 8.2 -0.6 -628 4.9 HDGF PKNOX1 ZNF133 GLIS2 FOS YY2 JUNB REST TSHZ1 TBX21 CCNL2 ENSG00000240731 LOC100288379 SLC35E2 ANKRD65 ENSG00000230092 LOC100129381 MIR6727 FAM87B B3GALT6
GH01F001413 0.8 FANTOM5 14.4 -206.6 -206602 0.0 KLF1 CREB3L1 SIN3A ZNF335 ZNF207 ZBTB20 MAZ NR4A1 NR2F1 ZBTB7A TNFRSF4 TNFRSF18 ANKRD65 ATAD3C TMEM88B GC01P001410 GC01M001386
GH01F001189 1 FANTOM5 9.2 +17.3 17318 0.3 MLX ZFP64 ARID4B DMAP1 RAD21 THRB YY1 RARA GATA4 THAP11 SDF4 B3GALT6 MIR200A MIR200B MIR429 LINC01786 UBE2J2 FAM132A SLC35E2 TNFRSF18
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFRSF18 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TNFRSF18 gene promoter:

Genomic Location for TNFRSF18 Gene

1,203,508 bp from pter
1,206,709 bp from pter
3,202 bases
Minus strand

Genomic View for TNFRSF18 Gene

Genes around TNFRSF18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF18 Gene

Proteins for TNFRSF18 Gene

  • Protein details for TNFRSF18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 18
    Protein Accession:
    Secondary Accessions:
    • B1AME1
    • O95851
    • Q5U0I4
    • Q9NYJ9

    Protein attributes for TNFRSF18 Gene

    241 amino acids
    Molecular mass:
    26000 Da
    Quaternary structure:
    • Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA.

    Alternative splice isoforms for TNFRSF18 Gene


neXtProt entry for TNFRSF18 Gene

Post-translational modifications for TNFRSF18 Gene

Other Protein References for TNFRSF18 Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF18 (GITR/TNFRSF18)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF18 (TNFRSF18)
  • Santa Cruz Biotechnology (SCBT) Antibodies for TNFRSF18

No data available for DME Specific Peptides for TNFRSF18 Gene

Domains & Families for TNFRSF18 Gene

Protein Domains for TNFRSF18 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 TNFR-Cys repeats.
  • Contains 3 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF18: view

Function for TNFRSF18 Gene

Molecular function for TNFRSF18 Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 18,expressed in normal T lymphocytes from thymus,spleen,lymphonodes,involved in regulation of T cell receptor-mediated cell death
UniProtKB/Swiss-Prot Function:
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
UniProtKB/Swiss-Prot Induction:
Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

Gene Ontology (GO) - Molecular Function for TNFRSF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005031 tumor necrosis factor-activated receptor activity IEA,TAS --
genes like me logo Genes that share ontologies with TNFRSF18: view
genes like me logo Genes that share phenotypes with TNFRSF18: view

Animal Models for TNFRSF18 Gene

MGI Knock Outs for TNFRSF18:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TNFRSF18 Gene

Localization for TNFRSF18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF18 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF18 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for TNFRSF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF18: view

Pathways & Interactions for TNFRSF18 Gene

genes like me logo Genes that share pathways with TNFRSF18: view

Gene Ontology (GO) - Biological Process for TNFRSF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002687 positive regulation of leukocyte migration IMP 23892569
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007165 signal transduction TAS 10074428
genes like me logo Genes that share ontologies with TNFRSF18: view

No data available for SIGNOR curated interactions for TNFRSF18 Gene

Drugs & Compounds for TNFRSF18 Gene

(2) Drugs for TNFRSF18 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TL6 Pharma 0
TRX518 Pharma 0
genes like me logo Genes that share compounds with TNFRSF18: view

Transcripts for TNFRSF18 Gene

Unigene Clusters for TNFRSF18 Gene

Tumor necrosis factor receptor superfamily, member 18:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF18 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP2: -

Relevant External Links for TNFRSF18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFRSF18 Gene

mRNA differential expression in normal tissues according to GTEx for TNFRSF18 Gene

This gene is overexpressed in Cervix - Endocervix (x7.1), Skin - Not Sun Exposed (Suprapubic) (x6.1), Whole Blood (x6.0), and Skin - Sun Exposed (Lower leg) (x4.9).

Protein differential expression in normal tissues from HIPED for TNFRSF18 Gene

This gene is overexpressed in Saliva (65.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF18 Gene

Protein tissue co-expression partners for TNFRSF18 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF18 Gene:


SOURCE GeneReport for Unigene cluster for TNFRSF18 Gene:


mRNA Expression by UniProt/SwissProt for TNFRSF18 Gene:

Tissue specificity: Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.
genes like me logo Genes that share expression patterns with TNFRSF18: view

Primer Products

Orthologs for TNFRSF18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFRSF18 34 35
  • 98.62 (n)
(Canis familiaris)
Mammalia TNFRSF18 34 35
  • 75.11 (n)
(Bos Taurus)
Mammalia TNFRSF18 34 35
  • 73.94 (n)
(Rattus norvegicus)
Mammalia Tnfrsf18 34
  • 71.79 (n)
(Mus musculus)
Mammalia Tnfrsf18 34 16 35
  • 70.68 (n)
(Monodelphis domestica)
Mammalia TNFRSF18 35
  • 26 (a)
(Ornithorhynchus anatinus)
Mammalia TNFRSF18 35
  • 17 (a)
(Gallus gallus)
Aves TNFRSF18 34 35
  • 47.41 (n)
(Anolis carolinensis)
Reptilia TNFRSF18 35
  • 23 (a)
(Danio rerio)
Actinopterygii tnfrsf18 35
  • 18 (a)
Species where no ortholog for TNFRSF18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF18 Gene

Gene Tree for TNFRSF18 (if available)
Gene Tree for TNFRSF18 (if available)

Paralogs for TNFRSF18 Gene

No data available for Paralogs for TNFRSF18 Gene

Variants for TNFRSF18 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111426889 -- 1,206,836(-) ATAAA(C/T)GCCGC upstream-variant-2KB, utr-variant-5-prime
rs111559683 -- 1,209,452(+) ACGGT(A/G)GCCGG upstream-variant-2KB
rs111765763 -- 1,204,868(+) CCAGA(A/C)CCTGC intron-variant
rs111812582 -- 1,208,542(+) CCCCA(C/T)GGGGA upstream-variant-2KB
rs111842318 -- 1,209,316(+) AGCCA(C/T)CCGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF18 Gene

Variant ID Type Subtype PubMed ID
dgv24n54 CNV loss 21841781
dgv2n67 CNV gain 20364138
nsv1003578 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160644 CNV deletion 26073780
nsv1160772 CNV duplication 26073780
nsv428334 CNV gain 18775914
nsv469848 CNV gain 16826518
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv517709 CNV gain+loss 19592680
nsv544947 CNV loss 21841781
nsv544956 CNV loss 21841781
nsv950452 CNV deletion 24416366
nsv544960 CNV loss 21841781

Variation tolerance for TNFRSF18 Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF18 Gene

Disorders for TNFRSF18 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TNFRSF18 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • diverticulitis nos
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFRSF18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TNFRSF18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF18 Gene

Publications for TNFRSF18 Gene

  1. Identification of three novel mRNA splice variants of GITR. (PMID: 10836847) Nocentini G. … Riccardi C. (Cell Death Differ. 2000) 3 4 22 64
  2. Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. (PMID: 10037686) Kwon B. … Kwon B.S. (J. Biol. Chem. 1999) 2 3 4 64
  3. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. (PMID: 10074428) Gurney A.L. … Ashkenazi A. (Curr. Biol. 1999) 3 4 22 64
  4. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 46 64
  5. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64

Products for TNFRSF18 Gene

Sources for TNFRSF18 Gene

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