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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF18 Gene

protein-coding   GIFtS: 59
GCID: GC01M001128

tumor necrosis factor receptor superfamily, member 18
 Explore 49 diseases affiliated with
TNFRSF18 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TNFRSF18    

Aliases
for TNFRSF18 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 181 2     Glucocorticoid-Induced TNFR-Related Protein2 3
AITR1 2 3 5     GITR-D2
GITR1 2 3 5     TNF Receptor Superfamily Activation-Inducible Protein2
CD3571 2     Tumor Necrosis Factor Receptor Superfamily Member 182
Activation-Inducible TNFR Family Receptor2 3     CD357 Antigen3

External Ids:    HGNC: 119141   Entrez Gene: 87842   Ensembl: ENSG000001868917   OMIM: 6039055   UniProtKB: Q9Y5U53   

Export aliases for TNFRSF18 gene to outside databases

Previous GC identifers: GC01M000665 GC01M000890 GC01M001015 GC01M001044 GC01M001179 GC01M000410


Summaries
for TNFRSF18 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TNFRSF18:
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased
expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance
maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in
the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript
variants of this gene encoding distinct isoforms have been reported. (provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5
Function: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial
cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK
pathway

Gene Wiki entry for TNFRSF18


Genomic Views
for TNFRSF18 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF18 gene promoter:
         GR   STAT1   p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF18 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.3

TNFRSF18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF18 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001128:  view genomic region     (about GC identifiers)

Start:
 1,138,888 bp from pter      End:
 1,142,089 bp from pter
Size:
 3,202 bases      Orientation:
 minus strand

Proteins
for TNFRSF18 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 18 precursor  
Size: 241 amino acids; 26000 Da
Subunit: Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
Secondary accessions: B1AME1 O95851 Q5U0I4 Q9NYJ9
Alternative splicing: 3 isoforms:  Q9Y5U5-1   Q9Y5U5-2   Q9Y5U5-3   

Explore the universe of human proteins at neXtProt for TNFRSF18: NX_Q9Y5U5

TNFRSF18 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins (3 alternative transcripts): 
NP_004186.1  NP_683699.1  NP_683700.1  

ENSEMBL proteins: 
 ENSP00000328207   ENSP00000368570   ENSP00000462735   ENSP00000368567  

Human Recombinant Protein Products: 
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R&D Systems Recombinant & Natural Proteins for TNFRSF18 (GITR/TNFRSF18)
Enzo Life Sciences proteins for TNFRSF18
OriGene Purified Protein: TNFRSF18
OriGene Protein Over-expression Lysate (see all 3): TNFRSF18
OriGene Custom Protein Services for TNFRSF18 
GenScript Custom Purified and Recombinant Proteins Services for TNFRSF18
Novus Biologicals TNFRSF18 Proteins
Novus Biologicals TNFRSF18 Lysates
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Uscn Proteins for TNFRSF18

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0005887integral to plasma membrane IEA--
GO:0009897external side of plasma membrane IEA--


TNFRSF18 for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for TNFRSF18

Protein Domains /
Families
for TNFRSF18 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
TNFRSF18 for domains           About GeneDecksing

2 InterPro domains/families:
 IPR001368 TNFR/NGFR_Cys_rich_reg
 IPR022318 TNFR_18

Graphical View of Domain Structure for InterPro Entry Q9Y5U5

ProtoNet protein and cluster: Q9Y5U5

1 Blocks protein family: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5
Similarity: Contains 3 TNFR-Cys repeats


Function
for TNFRSF18 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5
Function: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial
cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK
pathway
Induction: Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation

     Genatlas biochemistry entry for TNFRSF18:
tumor necrosis factor receptor superfamily,member 18,expressed in normal T lymphocytes from
thymus,spleen,lymphonodes,involved in regulation of T cell receptor-mediated cell death

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFRSF18
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SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF18 3' UTR sequence
Inhib. RNA
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OriGene shRNA RFP: TNFRSF18
OriGene siRNA: TNFRSF18
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFRSF18

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for TNFRSF18

Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF18 (see all 6)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF18 

Cell Line
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In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF18

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005031tumor necrosis factor-activated receptor activity TAS10074428
GO:0005515protein binding ----


TNFRSF18 for ontologies           About GeneDecksing


2 GenomeRNAi human phenotypes for TNFRSF18:
 Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

Animal Models:
     Mouse knock-out Tnfrsf18tm1Ppp for TNFRSF18
     3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tnfrsf18):
 cellular  hematopoietic system  immune system 

TNFRSF18 for phenotypes           About GeneDecksing


Pathways & Interactions
for TNFRSF18 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1PEDF Induced Signaling
STAT3 Pathway0.47
Glucocorticoid Receptor Signaling0.27
PGC1Alpha Pathway0.33
Cytokine-cytokine receptor interaction0.26
2TGF-Beta Pathway
TGF-Beta Pathway1.00
JNK Pathway0.50
JAK-STAT Pathway0.57
3Akt Signaling
Akt Signaling1.00
Tec Kinases Signaling0.55
p38 Signaling0.60
4Apoptosis and survival_Apoptotic TNF-family pathways
Apoptosis and survival_Apoptotic TNF-family pathways1.00
Apoptosis and survival Apoptotic TNF-family pathways1.00
5TRAF Pathway
TNF Superfamily Pathway0.42
TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.08

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TNFRSF18
    Apoptosis and survival Apoptotic TNF-family pathways

1 R&D Systems Pathway for TNFRSF18
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF18 (see all 13)
    STAT3 Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
Glucocorticoid Receptor Signaling
JAK-STAT Pathway

1 GeneGo (Thomson Reuters) Pathway for TNFRSF18
    Apoptosis and survival Apoptotic TNF-family pathways

1 BioSystems Pathway for TNFRSF18 
    Downstream signaling in naive CD8+ T cells


1         Kegg Pathway  (Kegg details for TNFRSF18):
    Cytokine-cytokine receptor interaction


TNFRSF18 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF18

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/12 Interacting proteins for TNFRSF18 (Q9Y5U53 ENSP000003282074) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
InteractantInteraction Details
GeneCardExternal ID(s)
MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
SPI1P179473, ENSP000002271634I2D: score=1 STRING: ENSP00000227163
TNFSF18Q9UNG23, ENSP000003854704I2D: score=1 STRING: ENSP00000385470
TRAF1Q130773, ENSP000003629944I2D: score=3 STRING: ENSP00000362994
TRAF2Q129333, ENSP000002476684I2D: score=3 STRING: ENSP00000247668
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006915apoptotic process IEA--
GO:0007165signal transduction TAS10074428
GO:0033209tumor necrosis factor-mediated signaling pathway TAS10074428
GO:0043066negative regulation of apoptotic process TAS10074428


TNFRSF18 for ontologies           About GeneDecksing



Drugs & Compounds
for TNFRSF18 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNFRSF18
Search CenterWatch for drugs/clinical trials and news about TNFRSF18 / TNR18 

Transcripts
for TNFRSF18 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for TNFRSF18 gene (3 alternative transcripts): 
NM_004195.2  NM_148901.1  NM_148902.1  

Unigene Cluster for TNFRSF18:

Tumor necrosis factor receptor superfamily, member 18
Hs.212680  [show with all ESTs]
Unigene Representative Sequence: NM_004195
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000328596 ENST00000379268(uc001ada.3 uc001adb.3 uc001adc.3 uc001add.3)
ENST00000486728 ENST00000379265

miRNA
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SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF18 3' UTR sequence
Inhib. RNA
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OriGene shRNA RFP: TNFRSF18
OriGene siRNA: TNFRSF18
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFRSF18
Clone
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GenScript: all cDNA clones in your preferred vector (see all 3): TNFRSF18 (NM_148901)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF18
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF18 
Primer
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF18
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF18

Additional cDNA sequence: 

AF117297.1 AF125304.1 AF241229.1 AY358877.1 BC152381.1 BC152386.1 BT019531.1 BT019532.1 

4 DOTS entries:

DT.75100166  DT.91856189  DT.92417886  DT.95085822 

24/27 AceView cDNA sequences (see all 27):

AI923712 BX115469 AF241229 AF117297 NM_148901 AW084829 NM_148902 AX781601 
AY358877 AX781595 AI499936 NM_004195 AX781597 AF125304 AX781599 BQ072868 
BP429506 BE047368 AX794366 BM920445 BI007820 BU944957 AW300857 BE244247 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF18    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1:                                    
SP2:                    -               


ECgene alternative splicing isoforms for TNFRSF18

Expression
for TNFRSF18 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNFRSF18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCCCTTCC

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

TNFRSF18 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
Stem Cell Differentiation: 2 LifeMap Cells 
NameCategory
Early limb mesenchymal cells (ELM cells) (Primary Cell)Bone, Cartilage, Limb
Definitive endoderm-like cells (A scalable, suspensi...)
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See TNFRSF18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFRSF18

SOURCE GeneReport for Unigene cluster: Hs.212680

UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5
Tissue specificity: Expressed in lymph node, peripheral blood leukocytes and weakly in spleen

    SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF18: 
          TNF Ligands & Receptors in human mouse rat
          Apoptosis 384HT in human mouse rat
          T-Cell Anergy & Immune Tolerance in human mouse rat

Primer
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In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF18

Orthologs
for TNFRSF18 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF18 gene from 2/9 species (see all 9)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves TNFRSF181 tumor necrosis factor receptor superfamily, member more 44.97(n)
37.5(a)		   419424  NM_001030874.1  NP_001026045.1 
zebrafish
(Danio rerio)		 Actinopterygii tnfrsf186
 tumor necrosis factor receptor superfamily, member...
 16(a)
 1 ↔ 1
 6(42906690-42915156)


ENSEMBL Gene Tree for TNFRSF18 (if available)
TreeFam Gene Tree for TNFRSF18 (if available) 

Paralogs
for TNFRSF18 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for TNFRSF18 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/151 NCBI SNPs in TNFRSF18 are shown (see all 151)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 1 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1163525211,2
F,--1138422(+) GGTGCT/CGCTGA 3 -- ds50011Minor allele frequency- C:0.03WA 118
rs1508136871,2
--1138482(+) TATCAC/GATCTC 3 -- ds50010--------
rs1851426141,2
--1138548(+) AGGGCC/TGGCCT 3 -- ds50010--------
rs1896690661,2
--1138562(+) GACGGA/GGCCGC 3 -- ds50010--------
rs114666991,2
H--1138711(-) CATTCC/ANGTCC 3 -- ds50016Minor allele frequency- A:0.00NA EU EA NS 390
rs114666981,2
C,F,--1138735(-) TGGGGG/CTGGGG 3 -- ds50016Minor allele frequency- C:0.12NA EU WA EA 332
rs1811741841,2
--1138823(+) AGCACC/GGTGCC 3 -- ds50010--------
rs38190011,2
C,F,H,--1138913(-) AGGNGA/GCCTTC 3 -- ut31 ese323Minor allele frequency- G:0.26NA EU NS EA WA CSA 2437
rs2020600171,2
--1138931(+) GGTCCC/TGTGCT 3 -- ut310--------
rs2013773031,2
C,F,--1138963(+) ACAGCC/TTCCCG 3 -- ut311Minor allele frequency- T:0.01EU 657

HapMap Linkage Disequilibrium report for TNFRSF18 (1138888 - 1142089 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TNFRSF18
     2 CNVs: 0001 30362

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFRSF18
DNA2.0 Custom Variant and Variant Library Synthesis for TNFRSF18

Disorders / Diseases
for TNFRSF18 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
TNFRSF18 for disorders           About GeneDecksing

OMIM gene information: 603905    OMIM disorders: --

20/49 diseases for TNFRSF18 (see all 49):    About MalaCards
graft versus host disease    hypersensitivity reaction type ii disease    spongiotic dermatitis    wegener's granulomatosis
leukemia/lymphoma    systemic lupus erythematosus    leukemia/lymphoma, t-cell    lupus erythematosus
inflammatory bowel disease    adult t-cell leukemia    atopic dermatitis    rheumatoid arthritis
dermatitis    acute myeloid leukemia    uveitis    ulcerative colitis
myeloid leukemia    filariasis    silicosis    kawasaki disease

10/13 Novoseek disease relationships for TNFRSF18 gene (see all 13)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis 62.9 72 17067317 (3), 16955181 (2), 16416233 (1), 17468835 (1) (see all 52)
autoimmune diseases 53.4 7 16868552 (1), 16520557 (1), 17359498 (1), 17963343 (1) (see all 6)
autoimmunity 49 1 16368528 (1)
tumors 45.7 56 17914571 (2), 16416233 (1), 19155305 (1), 19935370 (1) (see all 43)
graft-versus-host disease 42.6 2 15249593 (2)
inflammation 19 12 19234165 (1), 19760073 (1), 17525820 (1), 17804566 (1) (see all 5)
rheumatoid arthritis 18.6 3 17359498 (1), 17602748 (1)
cancer 15.7 2 17360848 (1), 16376102 (1)
uveitis 5.9 3 12892739 (2), 15326137 (1)
infection chronic 4.9 1 16368528 (1)

Human Genome Epidemiology (HuGE) Navigator: TNFRSF18 (10 documents)

Export disorders for TNFRSF18 gene to outside databases

Publications
for TNFRSF18 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TNFRSF18 gene, integrated from 9 sources (see all 185):
(articles sorted by number of sources associating them with TNFRSF18)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. (PubMed id 10037686)1, 2, 3, 9 Kwon B.... Kwon B.S. (1999)
  2. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. (PubMed id 10074428)1, 2, 9 Gurney A.L....Ashkenazi A. (1999)
  3. Identification of three novel mRNA splice variants of GITR. (PubMed id 10836847)1, 2, 9 Nocentini G.... Riccardi C. (2000)
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  6. A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. (PubMed id 9177197)1, 3 Nocentini G....Riccardi C. (1997)
  7. Glucocorticoid-induced tumor necrosis factor receptor negatively regulates activation of human primary natural killer (NK) cells by blocking proliferative signals and increasing NK cell apoptosis. (PubMed id 18230609)1, 9 Liu B....Nussenblatt R.B. (2008)
  8. Glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) in atopic dermatitis. (PubMed id 16955181)1, 9 Baumgartner-Nielsen J....Deleuran B. (2006)
  9. Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. (PubMed id 17360848)1, 9 Baltz K.M....Salih H.R. (2007)
  10. Glucocorticoid-induced tumor necrosis factor receptor-related protein ligand subverts immunosurveillance of acute myeloid leukemia in humans. (PubMed id 19155305)1, 9 Baessler T....Salih H.R. (2009)

External Searches for TNFRSF18 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Genome Databases showing TNFRSF18 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 8784 HGNC: 11914 AceView: TNFRSF18 Ensembl:ENSG00000186891 euGenes: HUgn8784
ECgene: TNFRSF18 Kegg: 8784 H-InvDB: TNFRSF18

Other Databases showing TNFRSF18 gene

(According to HUGE)
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Specialized Databases showing TNFRSF18 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TNFRSF18 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFRSF18 Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property
for TNFRSF18 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TNFRSF18 gene:
Search GeneIP for patents involving TNFRSF18

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