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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF18 Gene

protein-coding   GIFtS: 61
GCID: GC01M001128

Tumor Necrosis Factor Receptor Superfamily, Member 18

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 181 2     CD3572
AITR2 3 5     GITR-D2
GITR2 3 5     TNF Receptor Superfamily Activation-Inducible Protein2
Activation-Inducible TNFR Family Receptor2 3     Tumor Necrosis Factor Receptor Superfamily Member 182
Glucocorticoid-Induced TNFR-Related Protein2 3     CD357 Antigen3

External Ids:    HGNC: 119141   Entrez Gene: 87842   Ensembl: ENSG000001868917   OMIM: 6039055   UniProtKB: Q9Y5U53   

Export aliases for TNFRSF18 gene to outside databases

Previous GC identifers: GC01M000665 GC01M000890 GC01M001015 GC01M001044 GC01M001179 GC01M000410


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF18 Gene:
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased
expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance
maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor
is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced
transcript variants of this gene encoding distinct isoforms have been reported. (provided by RefSeq, Feb 2011)

GeneCards Summary for TNFRSF18 Gene: 
TNFRSF18 (tumor necrosis factor receptor superfamily, member 18) is a protein-coding gene. Diseases associated with TNFRSF18 include spongiotic dermatitis, and lumbar disc herniation, and among its related super-pathways are TNF Signaling and STAT3 Pathway. GO annotations related to this gene include tumor necrosis factor-activated receptor activity.

UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5
Function: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and
endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation
via the TRAF2/NIK pathway

Gene Wiki entry for TNFRSF18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004350.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF18 gene promoter:
         GR   STAT1   p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF18 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.3

TNFRSF18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF18 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001128:  view genomic region     (about GC identifiers)

Start:
1,138,888 bp from pter      End:
1,142,089 bp from pter
Size:
3,202 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 18 precursor  
Size: 241 amino acids; 26000 Da
Subunit: Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
Secondary accessions: B1AME1 O95851 Q5U0I4 Q9NYJ9
Alternative splicing: 3 isoforms:  Q9Y5U5-1   Q9Y5U5-2   Q9Y5U5-3   

Explore the universe of human proteins at neXtProt for TNFRSF18: NX_Q9Y5U5

Explore proteomics data for TNFRSF18 at MOPED 

TNFRSF18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TNFRSF18 Protein Expression

REFSEQ proteins (3 alternative transcripts): 
NP_004186.1  NP_683699.1  NP_683700.1  

ENSEMBL proteins: 
 ENSP00000328207   ENSP00000368570   ENSP00000462735   ENSP00000368567  

Human Recombinant Protein Products for TNFRSF18: 
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Sino Biological Recombinant Protein for TNFRSF18
Sino Biological Cell Lysate for TNFRSF18 
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Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0005887integral to plasma membrane IEA--
GO:0009897external side of plasma membrane IEA--

TNFRSF18 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CD: CD molecules
TNFRSF: Tumor necrosis factor receptor superfamily

IUPHAR Guide to PHARMACOLOGY protein family classification: glucocorticoid-induced TNF receptor 
Tumour necrosis factor (TNF) receptor family

2 InterPro protein domains:
 IPR001368 TNFR/NGFR_Cys_rich_reg
 IPR022318 TNFR_18

Graphical View of Domain Structure for InterPro Entry Q9Y5U5

ProtoNet protein and cluster: Q9Y5U5

1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5
Similarity: Contains 3 TNFR-Cys repeats


TNFRSF18 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TNR18_HUMAN, Q9Y5U5
Function: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and
endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation
via the TRAF2/NIK pathway
Induction: Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation

     Genatlas biochemistry entry for TNFRSF18:
tumor necrosis factor receptor superfamily,member 18,expressed in normal T lymphocytes from
thymus,spleen,lymphonodes,involved in regulation of T cell receptor-mediated cell death

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005031tumor necrosis factor-activated receptor activity TAS10074428
GO:0005515protein binding ----
     
TNFRSF18 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for TNFRSF18:
 Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tnfrsf18):
 cellular  hematopoietic system  immune system 

TNFRSF18 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Tnfrsf18tm1Ppp for TNFRSF18

   inGenious Targeting Laboratory - Custom generated mouse model solutions for TNFRSF18 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNFRSF18

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Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF18


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TNFRSF18 About   (see all 10)                                                                                              See pathways by source

SuperPathContained pathways About
1TNF Signaling
TNF Signaling0.50
TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.49
Death Receptor Signaling0.50
NF-kB (NFkB) Pathway0.46
2PEDF Induced Signaling
PGC1Alpha Pathway0.51
Glucocorticoid Receptor Signaling0.43
STAT3 Pathway0.47
Cytokine-cytokine receptor interaction0.43
3Akt Signaling
Akt Signaling0.60
Tec Kinases Signaling0.55
p38 Signaling0.60
4TGF-Beta Pathway
TGF-Beta Pathway0.60
JNK Pathway0.51
JAK-STAT Pathway0.57
5PAK Pathway
Antioxidant Action of Vitamin-C0.56

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for TNFRSF18
    Apoptosis and survival Apoptotic TNF-family pathways

1 R&D Systems Pathway for TNFRSF18
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF18 (see all 13)
    STAT3 Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
Glucocorticoid Receptor Signaling
JAK-STAT Pathway

1 GeneGo (Thomson Reuters) Pathway for TNFRSF18
    Apoptosis and survival Apoptotic TNF-family pathways

1 BioSystems Pathway for TNFRSF18
    Downstream signaling in naive CD8+ T cells

3 Sino Biological Pathways for TNFRSF18 
    TNF Signaling
Death Receptor Signaling
NF-kB (NFkB) Pathway


1         Kegg Pathway  (Kegg details for TNFRSF18):
    Cytokine-cytokine receptor interaction


TNFRSF18 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF18

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/12 Interacting proteins for TNFRSF18 (Q9Y5U53 ENSP000003282074) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
InteractantInteraction Details
GeneCardExternal ID(s)
MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
SPI1P179473, ENSP000002271634I2D: score=1 STRING: ENSP00000227163
TNFSF18Q9UNG23, ENSP000003854704I2D: score=1 STRING: ENSP00000385470
TRAF1Q130773, ENSP000003629944I2D: score=3 STRING: ENSP00000362994
TRAF2Q129333, ENSP000002476684I2D: score=3 STRING: ENSP00000247668
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006915apoptotic process ----
GO:0007165signal transduction TAS10074428
GO:0033209tumor necrosis factor-mediated signaling pathway TAS10074428
GO:0043066negative regulation of apoptotic process TAS10074428

TNFRSF18 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNFRSF18 (TNR18)

1 IUPHAR Ligand for TNFRSF18 (glucocorticoid-induced TNF receptor)    About this table 
LigandTypeActionAffinityPubmed IDs
TL6
NoneNone--

Search CenterWatch for drugs/clinical trials and news about TNFRSF18 / TNR18

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNFRSF18 gene (3 alternative transcripts): 
NM_004195.2  NM_148901.1  NM_148902.1  

Unigene Cluster for TNFRSF18:

Tumor necrosis factor receptor superfamily, member 18
Hs.212680  [show with all ESTs]
Unigene Representative Sequence: NM_004195
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000328596 ENST00000379268(uc001ada.3 uc001adb.3 uc001adc.3 uc001add.3)
ENST00000486728 ENST00000379265
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFRSF18
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SwitchGear 3'UTR luciferase reporter plasmidTNFRSF18 3' UTR sequence
Inhib. RNA
Products:
     
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GenScript: all cDNA clones in your preferred vector (see all 3): TNFRSF18 (NM_148901)
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF18
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF18

Additional mRNA sequence: 

AF117297.1 AF125304.1 AF241229.1 AY358877.1 BC152381.1 BC152386.1 BT019531.1 BT019532.1 

4 DOTS entries:

DT.75100166  DT.91856189  DT.92417886  DT.95085822 

24/27 AceView cDNA sequences (see all 27):

NM_148901 AI499936 AF125304 AX781601 AX781597 AY358877 AF241229 AF117297 
BX115469 AX781595 AI923712 NM_148902 NM_004195 AW084829 BE047368 BM920445 
BP429506 BQ072868 AX794366 AX781599 AW300857 BU944957 BI007820 BE244247 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF18    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1:                                    
SP2:                    -               


ECgene alternative splicing isoforms for TNFRSF18

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNFRSF18 expression in normal human tissues (normalized intensities)      TNFRSF18 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCCCCTTCC
TNFRSF18 Expression
About this image


TNFRSF18 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/17 selected tissues (see all 17) fully expand
 
 Tonsil (Hematopoietic System)    fully expand to see all 2 entries
         tonsil ; non-germinal center cells   
 
 Blood (Hematopoietic System)
         lung ; macrophages   
 
 Colon (Gastrointestinal Tract)
         colon ; endothelial cells   
 
 Gut Tube (Gastrointestinal Tract)
         Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
 
 Cartilage (Muscoskeletal System)
         fetal cartilage   

See TNFRSF18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFRSF18

SOURCE GeneReport for Unigene cluster: Hs.212680

UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5
Tissue specificity: Expressed in lymph node, peripheral blood leukocytes and weakly in spleen

    SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF18: 
          TNF Ligands & Receptors in human mouse rat
          Apoptosis 384HT in human mouse rat
          T-Cell Anergy & Immune Tolerance in human mouse rat

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF18
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF18

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF18 gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tnfrsf181 , 5 tumor necrosis factor receptor superfamily, member more1, 5 68.14(n)1
59.29(a)1
  4 (87.76 cM)5
219361  NM_009400.21  NP_033426.11 
 1560261645 
chicken
(Gallus gallus)
Aves TNFRSF181 tumor necrosis factor receptor superfamily, member more 44.97(n)
37.5(a)
  419424  NM_001030874.1  NP_001026045.1 
lizard
(Anolis carolinensis)
Reptilia TNFRSF186
tumor necrosis factor receptor superfamily, member...
18(a)
1 ↔ 1
GL343647.1(346742-357257)
zebrafish
(Danio rerio)
Actinopterygii tnfrsf186
tumor necrosis factor receptor superfamily, member...
13(a)
1 ↔ 1
6(42906690-42915156)


ENSEMBL Gene Tree for TNFRSF18 (if available)
TreeFam Gene Tree for TNFRSF18 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/221 SNPs in TNFRSF18 are shown (see all 221)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1163525211,2
F--1138422(+) GGTGCT/CGCTGA 3 -- ds50011Minor allele frequency- C:0.03WA 118
rs1508136871,2
--1138482(+) TATCAC/GATCTC 3 -- ds50010--------
rs1851426141,2
--1138548(+) AGGGCC/TGGCCT 3 -- ds50010--------
rs1896690661,2
--1138562(+) GACGGA/GGCCGC 3 -- ds50010--------
rs114666991,2
C,F,H--1138710(-) CATTCC/ANGTCC 3 -- ds50019Minor allele frequency- A:0.19NA EU EA NS 482
rs114666981,2
C,F--1138735(-) TGGGGG/CTGGGG 3 -- ds50016Minor allele frequency- C:0.12NA EU WA EA 332
rs1811741841,2
C--1138823(+) AGCACC/GGTGCC 3 -- ds50010--------
rs38190011,2
C,F,H--1138913(-) AGGGGA/GCCTTC 3 -- ut31 ese323Minor allele frequency- G:0.26NA EU NS EA WA CSA 2437
rs2020600171,2
--1138931(+) GGTCCC/TGTGCT 3 -- ut310--------
rs2013773031,2
C,F--1138963(+) ACAGCC/TTCCCG 3 -- ut311Minor allele frequency- T:0.01EU 657

HapMap Linkage Disequilibrium report for TNFRSF18 (1138888 - 1142089 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/30 variations for TNFRSF18 (see all 30):    About this table     
Variant IDTypeSubtypePubMed ID
dgv24n71CNV Loss21882294
dgv17n71CNV Loss21882294
nsv470680CNV Loss18288195
nsv871680CNV Loss21882294
nsv482937CNV Loss15286789
nsv871512CNV Loss21882294
nsv871133CNV Loss21882294
dgv12n71CNV Loss21882294
dgv25n71CNV Loss21882294
dgv21n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 603905    OMIM disorders: --

20/45 diseases for TNFRSF18 (see all 45):    About MalaCards
spongiotic dermatitis    lumbar disc herniation    chronic graft versus host disease    filariasis
silicosis    hypersensitivity reaction type ii disease    graft versus host disease    autoimmune hepatitis
uveitis    wegener's granulomatosis    kawasaki disease    adult t-cell leukemia
autoimmune thyroiditis    dermatitis    esophageal adenocarcinoma    pertussis
graves' disease    atopic dermatitis    ulcerative colitis    t-cell leukemia


TNFRSF18 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

10/13 Novoseek inferred disease relationships for TNFRSF18 gene (see all 13)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis 62.9 72 17067317 (3), 16955181 (2), 16416233 (1), 17468835 (1) (see all 52)
autoimmune diseases 53.4 7 16868552 (1), 16520557 (1), 17359498 (1), 17963343 (1) (see all 6)
autoimmunity 49 1 16368528 (1)
tumors 45.7 56 17914571 (2), 16416233 (1), 19155305 (1), 19935370 (1) (see all 43)
graft-versus-host disease 42.6 2 15249593 (2)
inflammation 19 12 19234165 (1), 19760073 (1), 17525820 (1), 17804566 (1) (see all 5)
rheumatoid arthritis 18.6 3 17359498 (1), 17602748 (1)
cancer 15.7 2 17360848 (1), 16376102 (1)
uveitis 5.9 3 12892739 (2), 15326137 (1)
infection chronic 4.9 1 16368528 (1)

Genetic Association Database (GAD): TNFRSF18
Human Genome Epidemiology (HuGE) Navigator: TNFRSF18 (10 documents)

Export disorders for TNFRSF18 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TNFRSF18 gene, integrated from 9 sources (see all 189):
(articles sorted by number of sources associating them with TNFRSF18)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. (PubMed id 10037686)1, 2, 3, 9 Kwon B.... Kwon B.S. (1999)
  2. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. (PubMed id 10074428)1, 2, 9 Gurney A.L....Ashkenazi A. (1999)
  3. Identification of three novel mRNA splice variants of GITR. (PubMed id 10836847)1, 2, 9 Nocentini G.... Riccardi C. (2000)
  4. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
  5. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
  6. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
  7. Common genetic variants in candidate genes and risk o f familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (2009)
  8. Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. (PubMed id 18987746)1, 4 Kimman T.G....Kerkhof M. (2008)
  9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
  10. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PubMed id 15301860)1, 4 Cho S.M....Lee J.K. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 8784 HGNC: 11914 AceView: TNFRSF18 Ensembl:ENSG00000186891 euGenes: HUgn8784
ECgene: TNFRSF18 Kegg: 8784 H-InvDB: TNFRSF18

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TNFRSF18 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFRSF18 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TNFRSF18 gene:
Search GeneIP for patents involving TNFRSF18

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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