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TNFRSF18 Gene

protein-coding   GIFtS: 61
GCID: GC01M001128

Tumor Necrosis Factor Receptor Superfamily, Member 18

  See TNFRSF18-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 181 2     CD3572
AITR2 3 5     GITR-D2
GITR2 3 5     TNF Receptor Superfamily Activation-Inducible Protein2
Activation-Inducible TNFR Family Receptor2 3     Tumor Necrosis Factor Receptor Superfamily Member 182
Glucocorticoid-Induced TNFR-Related Protein2 3     CD357 Antigen3

External Ids:    HGNC: 119141   Entrez Gene: 87842   Ensembl: ENSG000001868917   OMIM: 6039055   UniProtKB: Q9Y5U53   

Export aliases for TNFRSF18 gene to outside databases

Previous GC identifers: GC01M000665 GC01M000890 GC01M001015 GC01M001044 GC01M001179 GC01M000410


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFRSF18 Gene:
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased
expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance
maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor
is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced
transcript variants of this gene encoding distinct isoforms have been reported. (provided by RefSeq, Feb 2011)

GeneCards Summary for TNFRSF18 Gene:
TNFRSF18 (tumor necrosis factor receptor superfamily, member 18) is a protein-coding gene. Diseases associated with TNFRSF18 include diverticulitis, and wegener's granulomatosis. GO annotations related to this gene include tumor necrosis factor-activated receptor activity.

UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5
Function: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and
endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation
via the TRAF2/NIK pathway

Gene Wiki entry for TNFRSF18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFRSF18 gene promoter:
         GR   STAT1   p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF18 promoter sequence
   Search Chromatin IP Primers for TNFRSF18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.3

TNFRSF18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF18 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001128:  view genomic region     (about GC identifiers)

Start:
1,138,888 bp from pter      End:
1,142,089 bp from pter
Size:
3,202 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 18 precursor  
Size: 241 amino acids; 26000 Da
Subunit: Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA
Secondary accessions: B1AME1 O95851 Q5U0I4 Q9NYJ9
Alternative splicing: 3 isoforms:  Q9Y5U5-1   Q9Y5U5-2   Q9Y5U5-3   

Explore the universe of human proteins at neXtProt for TNFRSF18: NX_Q9Y5U5

Explore proteomics data for TNFRSF18 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn146

  • See TNFRSF18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_004186.1  NP_683699.1  NP_683700.1  

    ENSEMBL proteins: 
     ENSP00000328207   ENSP00000368570   ENSP00000462735   ENSP00000368567  

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    Novus Biologicals TNFRSF18 Proteins
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    Sino Biological Recombinant Protein for TNFRSF18
    Sino Biological Cell Lysate for TNFRSF18
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TNFRSF18 

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    Search eBioscience for ELISAs for TNFRSF18 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: glucocorticoid-induced TNF receptor
    Tumour necrosis factor (TNF) receptor family

    2 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR022318 TNFR_18

    Graphical View of Domain Structure for InterPro Entry Q9Y5U5

    ProtoNet protein and cluster: Q9Y5U5

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5
    Similarity: Contains 3 TNFR-Cys repeats


    Find genes that share domains with TNFRSF18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR18_HUMAN, Q9Y5U5
    Function: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and
    endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation
    via the TRAF2/NIK pathway
    Induction: Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation

         Genatlas biochemistry entry for TNFRSF18:
    tumor necrosis factor receptor superfamily,member 18,expressed in normal T lymphocytes from
    thymus,spleen,lymphonodes,involved in regulation of T cell receptor-mediated cell death

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005031tumor necrosis factor-activated receptor activity TAS10074428
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TNFRSF18           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNFRSF18:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tnfrsf18):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with TNFRSF18           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tnfrsf18tm1Ppp for TNFRSF18

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFRSF18
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNR18_HUMAN, Q9Y5U5: Isoform 1: Cell membrane; Single-pass type I membrane protein
    TNR18_HUMAN, Q9Y5U5: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005887integral component of plasma membrane IEA--
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with TNFRSF18           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFRSF18 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    PGC1Alpha Pathway0.51
    Glucocorticoid Receptor Signaling0.43
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    JAK-STAT Pathway0.57
    5PAK Pathway
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with TNFRSF18           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFRSF18
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF18 (see all 13)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Glucocorticoid Receptor Signaling
    JAK-STAT Pathway

    1 GeneGo (Thomson Reuters) Pathway for TNFRSF18
        Apoptosis and survival Apoptotic TNF-family pathways

    1 BioSystems Pathway for TNFRSF18
        Downstream signaling in naive CD8+ T cells

    3 Sino Biological Pathways for TNFRSF18
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1 Kegg Pathway  (Kegg details for TNFRSF18):
        Cytokine-cytokine receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF18: 
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFRSF18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for TNFRSF18 (Q9Y5U53 ENSP000003282074) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    SPI1P179473, ENSP000002271634I2D: score=1 STRING: ENSP00000227163
    TNFSF18Q9UNG23, ENSP000003854704I2D: score=1 STRING: ENSP00000385470
    TRAF1Q130773, ENSP000003629944I2D: score=3 STRING: ENSP00000362994
    TRAF2Q129333, ENSP000002476684I2D: score=3 STRING: ENSP00000247668
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction TAS10074428
    GO:0033209tumor necrosis factor-mediated signaling pathway TAS10074428
    GO:0043066negative regulation of apoptotic process TAS10074428

    Find genes that share ontologies with TNFRSF18           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFRSF18 (TNR18)

    1 IUPHAR Ligand for TNFRSF18 (glucocorticoid-induced TNF receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    TL6
    NoneNone--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNFRSF18 gene (3 alternative transcripts): 
    NM_004195.2  NM_148901.1  NM_148902.1  

    Unigene Cluster for TNFRSF18:

    Tumor necrosis factor receptor superfamily, member 18
    Hs.212680  [show with all ESTs]
    Unigene Representative Sequence: NM_004195
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328596 ENST00000379268(uc001ada.3 uc001adb.3 uc001adc.3 uc001add.3)
    ENST00000486728 ENST00000379265
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    Additional mRNA sequence: 

    AF117297.1 AF125304.1 AF241229.1 AY358877.1 BC152381.1 BC152386.1 BT019531.1 BT019532.1 

    4 DOTS entries:

    DT.75100166  DT.91856189  DT.92417886  DT.95085822 

    Selected AceView cDNA sequences (see all 27):

    AW084829 AX781595 AF117297 AI499936 AX781597 BX115469 NM_148902 AI923712 
    AY358877 AF125304 NM_004195 NM_148901 AX781601 AF241229 BM920445 BE047368 
    BQ072868 AX794366 AX781599 BP429506 AW300857 BI007820 BU944957 BE244247 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF18    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
    SP1:                                    
    SP2:                    -               


    ECgene alternative splicing isoforms for TNFRSF18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFRSF18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCCTTCC
    TNFRSF18 Expression
    About this image


    TNFRSF18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
    TNFRSF18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFRSF18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.212680

    UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5
    Tissue specificity: Expressed in lymph node, peripheral blood leukocytes and weakly in spleen

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF18: 
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF18 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf181 , 5 tumor necrosis factor receptor superfamily, member more1, 5 70.68(n)1
    61.26(a)1
      4 (87.76 cM)5
    219361  NM_009400.21  NP_033426.11 
     1560261645 
    chicken
    (Gallus gallus)
    Aves TNFRSF181 tumor necrosis factor receptor superfamily, member more 47.41(n)
    39.75(a)
      419424  NM_001030874.1  NP_001026045.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNFRSF186
    tumor necrosis factor receptor superfamily, member...
    23(a)
    1 ↔ 1
    GL343647.1(346742-357257)
    zebrafish
    (Danio rerio)
    Actinopterygii tnfrsf186
    tumor necrosis factor receptor superfamily, member...
    18(a)
    1 ↔ 1
    6(42906690-42915156) ENSDARG00000076800


    ENSEMBL Gene Tree for TNFRSF18 (if available)
    TreeFam Gene Tree for TNFRSF18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFRSF18 (see all 221)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1163525211,2
    F--1138422(+) GGTGCT/CGCTGA 3 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1508136871,2
    --1138482(+) TATCAC/GATCTC 3 -- ds50010--------
    rs1851426141,2
    --1138548(+) AGGGCC/TGGCCT 3 -- ds50010--------
    rs1896690661,2
    --1138562(+) GACGGA/GGCCGC 3 -- ds50010--------
    rs114666991,2
    C,F,H--1138710(-) CATTCC/ANGTCC 3 -- ds50019Minor allele frequency- A:0.19NA EU EA NS 482
    rs114666981,2
    C,F--1138735(-) TGGGGG/CTGGGG 3 -- ds50016Minor allele frequency- C:0.12NA EU WA EA 332
    rs1811741841,2
    C--1138823(+) AGCACC/GGTGCC 3 -- ds50010--------
    rs38190011,2
    C,F,H--1138913(-) AGGGGA/GCCTTC 3 -- ut31 ese323Minor allele frequency- G:0.26NA EU NS EA WA CSA 2437
    rs2020600171,2
    --1138931(+) GGTCCC/TGTGCT 3 -- ut310--------
    rs2013773031,2
    C,F--1138963(+) ACAGCC/TTCCCG 3 -- ut311Minor allele frequency- T:0.01EU 657

    HapMap Linkage Disequilibrium report for TNFRSF18 (1138888 - 1142089 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TNFRSF18 (see all 30):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv24n71CNV Loss21882294
    dgv17n71CNV Loss21882294
    nsv470680CNV Loss18288195
    nsv871680CNV Loss21882294
    nsv482937CNV Loss15286789
    nsv871512CNV Loss21882294
    nsv871133CNV Loss21882294
    dgv12n71CNV Loss21882294
    dgv25n71CNV Loss21882294
    dgv21n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 603905    OMIM disorders: --

    2 diseases for TNFRSF18:    
    About MalaCards
    diverticulitis    wegener's granulomatosis


    Find genes that share disorders with TNFRSF18           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TNFRSF18 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 62.9 72 17067317 (3), 16955181 (2), 16416233 (1), 17468835 (1) (see all 52)
    autoimmune diseases 53.4 7 16868552 (1), 16520557 (1), 17359498 (1), 17963343 (1) (see all 6)
    autoimmunity 49 1 16368528 (1)
    tumors 45.7 56 17914571 (2), 16416233 (1), 19155305 (1), 19935370 (1) (see all 43)
    graft-versus-host disease 42.6 2 15249593 (2)
    inflammation 19 12 19234165 (1), 19760073 (1), 17525820 (1), 17804566 (1) (see all 5)
    rheumatoid arthritis 18.6 3 17359498 (1), 17602748 (1)
    cancer 15.7 2 17360848 (1), 16376102 (1)
    uveitis 5.9 3 12892739 (2), 15326137 (1)
    infection chronic 4.9 1 16368528 (1)

    Genetic Association Database (GAD): TNFRSF18
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF18 (10 documents)

    Export disorders for TNFRSF18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TNFRSF18 gene, integrated from 10 sources (see all 191):
    (articles sorted by number of sources associating them with TNFRSF18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. (PubMed id 10037686)1, 2, 3, 9 Kwon B.... Kwon B.S. (J. Biol. Chem. 1999)
    2. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. (PubMed id 10074428)1, 2, 9 Gurney A.L....Ashkenazi A. (Curr. Biol. 1999)
    3. Identification of three novel mRNA splice variants of GITR. (PubMed id 10836847)1, 2, 9 Nocentini G.... Riccardi C. (Cell Death Differ. 2000)
    4. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    6. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    7. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    8. Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. (PubMed id 18987746)1, 4 Kimman T.G....Kerkhof M. (PLoS ONE 2008)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    10. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PubMed id 15301860)1, 4 Cho S.M....Lee J.K. (Hum. Immunol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8784 HGNC: 11914 AceView: TNFRSF18 Ensembl:ENSG00000186891 euGenes: HUgn8784
    ECgene: TNFRSF18 Kegg: 8784 H-InvDB: TNFRSF18

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TNFRSF18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF18 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TNFRSF18 gene:
    Search GeneIP for patents involving TNFRSF18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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