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Aliases for TNFRSF17 Gene

Aliases for TNFRSF17 Gene

  • TNF Receptor Superfamily Member 17 2 3 5
  • B-Cell Maturation Protein 3 4
  • BCMA 3 4
  • BCM 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 17 2
  • Tumor Necrosis Factor Receptor Superfamily Member 17 3
  • B Cell Maturation Antigen 3
  • B-Cell Maturation Factor 3
  • CD269 Antigen 4
  • TNFRSF13A 3
  • CD269 3

External Ids for TNFRSF17 Gene

Previous HGNC Symbols for TNFRSF17 Gene

  • BCMA

Previous GeneCards Identifiers for TNFRSF17 Gene

  • GC16P011842
  • GC16P012211
  • GC16P012025
  • GC16P011966

Summaries for TNFRSF17 Gene

Entrez Gene Summary for TNFRSF17 Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF17 Gene

TNFRSF17 (TNF Receptor Superfamily Member 17) is a Protein Coding gene. Diseases associated with TNFRSF17 include Common Variable Immunodeficiency and Chronic Lymphocytic Leukemia. Among its related pathways are RANK Signaling in Osteoclasts and Akt Signaling. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for TNFRSF17 Gene

  • Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

Gene Wiki entry for TNFRSF17 Gene

Additional gene information for TNFRSF17 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF17 Gene

Genomics for TNFRSF17 Gene

Regulatory Elements for TNFRSF17 Gene

Enhancers for TNFRSF17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H011993 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.5 +29.6 29594 2.2 L3MBTL2 ZNF175 MAX USF2 EBF1 ZNF7 MITF IKZF1 NR2C1 MLLT1 NPIPB2 TNFRSF17 TXNDC11 SNN SNX29 LITAF ZC3H7A ENSG00000260488 RPS23P6
GH16H012002 1.3 Ensembl ENCODE dbSUPER 12.9 +37.6 37553 0.8 PKNOX1 ATF1 ZBTB21 TAL1 JUN ZNF175 FOSL1 TCF12 POLR2A NCOR1 NPIPB2 TNFRSF17 ENSG00000260488 RPS23P6
GH16H012009 1.2 Ensembl ENCODE dbSUPER 12.3 +45.5 45525 2.4 SMARCE1 FOXA2 TAL1 MAX EBF1 DPF2 FOSL1 TCF12 ZNF766 SMARCA4 NPIPB2 TNFRSF17 ENSG00000260488 RPS23P6
GH16H011913 1.2 ENCODE 11.2 -49.7 -49669 4.6 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 GLIS1 NPIPB2 LOC105371084 RSL1D1 HNRNPCP4 ENSG00000261560 TNFRSF17 SOCS1 ENSG00000260488 GSPT1 PIR60564
GH16H011867 0.9 ENCODE 11.7 -97.4 -97419 0.9 PKNOX1 FOXA2 NFIB INSM2 ARID4B DMAP1 THRB POLR3A FOS ZNF391 TNFRSF17 NPIPB2 GSPT1 ENSG00000260488 ENSG00000261560 RSL1D1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFRSF17 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TNFRSF17 Gene

Genomic Locations for TNFRSF17 Gene
2,962 bases
Plus strand

Genomic View for TNFRSF17 Gene

Genes around TNFRSF17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF17 Gene

Proteins for TNFRSF17 Gene

  • Protein details for TNFRSF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 17
    Protein Accession:
    Secondary Accessions:
    • Q2TQ40

    Protein attributes for TNFRSF17 Gene

    184 amino acids
    Molecular mass:
    20165 Da
    Quaternary structure:
    • Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.

    Three dimensional structures from OCA and Proteopedia for TNFRSF17 Gene

    Alternative splice isoforms for TNFRSF17 Gene


neXtProt entry for TNFRSF17 Gene

Post-translational modifications for TNFRSF17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNFRSF17 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFRSF17 (BCMA/TNFRSF17)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF17 (TNFRSF17)
  • Abcam antibodies for TNFRSF17

No data available for DME Specific Peptides for TNFRSF17 Gene

Domains & Families for TNFRSF17 Gene

Gene Families for TNFRSF17 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TNFRSF17 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFRSF17: view

No data available for UniProtKB/Swiss-Prot for TNFRSF17 Gene

Function for TNFRSF17 Gene

Molecular function for TNFRSF17 Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 17,B cell maturation gene,expressed in terminal stages of B cell differentiation,fused with IL2 in t(4;16)(q26;p13) translocation
UniProtKB/Swiss-Prot Function:
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

Gene Ontology (GO) - Molecular Function for TNFRSF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS,IEA --
genes like me logo Genes that share ontologies with TNFRSF17: view
genes like me logo Genes that share phenotypes with TNFRSF17: view

Animal Models for TNFRSF17 Gene

MGI Knock Outs for TNFRSF17:

Animal Model Products

miRNA for TNFRSF17 Gene

miRTarBase miRNAs that target TNFRSF17

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF17 Gene

Localization for TNFRSF17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF17 Gene

Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF17 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TNFRSF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFRSF17 Gene

Pathways & Interactions for TNFRSF17 Gene

genes like me logo Genes that share pathways with TNFRSF17: view

SIGNOR curated interactions for TNFRSF17 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TNFRSF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002260 lymphocyte homeostasis IEA --
GO:0002376 immune system process IEA --
GO:0007165 signal transduction TAS 10908663
GO:0007275 multicellular organism development TAS 8165126
genes like me logo Genes that share ontologies with TNFRSF17: view

Drugs & Compounds for TNFRSF17 Gene

(4) Drugs for TNFRSF17 Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
APRIL Pharma 0
BAFF Pharma 0

(2) Additional Compounds for TNFRSF17 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF17: view

Transcripts for TNFRSF17 Gene

mRNA/cDNA for TNFRSF17 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFRSF17 Gene

Tumor necrosis factor receptor superfamily, member 17:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF17 Gene

No ASD Table

Relevant External Links for TNFRSF17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF17 Gene

This gene is overexpressed in Spleen (x5.0).

Protein differential expression in normal tissues from HIPED for TNFRSF17 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TNFRSF17 Gene

Protein tissue co-expression partners for TNFRSF17 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF17 Gene:


SOURCE GeneReport for Unigene cluster for TNFRSF17 Gene:


mRNA Expression by UniProt/SwissProt for TNFRSF17 Gene:

Tissue specificity: Expressed in mature B-cells, but not in T-cells or monocytes.

Evidence on tissue expression from TISSUES for TNFRSF17 Gene

  • Blood(4.5)
  • Lymph node(4.4)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with TNFRSF17: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF17 Gene

Orthologs for TNFRSF17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TNFRSF17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFRSF17 33 34
  • 99.82 (n)
(Canis familiaris)
Mammalia TNFRSF17 33 34
  • 83.53 (n)
(Bos Taurus)
Mammalia TNFRSF17 33
  • 79.81 (n)
(Mus musculus)
Mammalia Tnfrsf17 33 16 34
  • 75.05 (n)
(Rattus norvegicus)
Mammalia Tnfrsf17 33
  • 74.86 (n)
(Monodelphis domestica)
Mammalia TNFRSF17 34
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia TNFRSF17 34
  • 45 (a)
Species where no ortholog for TNFRSF17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFRSF17 Gene

Gene Tree for TNFRSF17 (if available)
Gene Tree for TNFRSF17 (if available)

Paralogs for TNFRSF17 Gene

No data available for Paralogs for TNFRSF17 Gene

Variants for TNFRSF17 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF17 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000713202 -- 11,966,624(+) TCTTT(C/G)ACTAA intron-variant
rs1000777717 -- 11,965,609(+) TGGAA(A/C)CAAAG intron-variant
rs1001083273 -- 11,966,959(+) AGCCA(C/T)TGCCC intron-variant
rs1002798107 -- 11,963,988(+) TGTGA(G/T)TGTGT upstream-variant-2KB
rs1003187878 -- 11,965,513(+) TGGAC(G/T)GCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF17 Gene

Variant ID Type Subtype PubMed ID
nsv571459 CNV loss 21841781
nsv571458 CNV gain 21841781
nsv1043959 CNV gain 25217958

Variation tolerance for TNFRSF17 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF17 Gene

Disorders for TNFRSF17 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TNFRSF17 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
common variable immunodeficiency
  • acquired agammaglobulinemia
chronic lymphocytic leukemia
  • b-cell chronic lymphocytic leukemia
blue cone monochromacy
  • blue cone monochromatism
- elite association - COSMIC cancer census association via MalaCards


  • Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2. {ECO:0000269 PubMed:1396583}.

Relevant External Links for TNFRSF17

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TNFRSF17: view

No data available for Genatlas for TNFRSF17 Gene

Publications for TNFRSF17 Gene

  1. The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed. (PMID: 8165126) Laabi Y … Tsapis A (Nucleic acids research 1994) 2 3 4 22 60
  2. Identification of new splice variants of the genes BAFF and BCMA. (PMID: 17825416) Smirnova AS … Gerbase-DeLima M (Molecular immunology 2008) 3 4 22 60
  3. Ligand-receptor binding revealed by the TNF family member TALL-1. (PMID: 12721620) Liu Y … Zhang G (Nature 2003) 3 4 22 60
  4. Presence of four major haplotypes in human BCMA gene: lack of association with systemic lupus erythematosus and rheumatoid arthritis. (PMID: 11528522) Kawasaki A … Tokunaga K (Genes and immunity 2001) 3 4 45 60
  5. TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. (PMID: 10903733) Hatzoglou A … Tsapis A (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22 60

Products for TNFRSF17 Gene

Sources for TNFRSF17 Gene

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