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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF17 Gene

protein-coding   GIFtS: 62
GCID: GC16P012058

tumor necrosis factor receptor superfamily, member 17


(Previous symbol: BCMA)
 Explore 35 diseases affiliated with
TNFRSF17 via our new
 Human Malady Compendium 
Biological research products
for TNFRSF17
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 171 2     B Cell Maturation Antigen2
BCMA1 2 3 5     B-Cell Maturation Factor2
BCM1 2 3     Tumor Necrosis Factor Receptor Superfamily Member 172
CD2691 2     CD269 Antigen3
B-Cell Maturation Protein2 3     

External Ids:    HGNC: 119131   Entrez Gene: 6082   Ensembl: ENSG000000484627   OMIM: 1095455   UniProtKB: Q022233   

Export aliases for TNFRSF17 gene to outside databases

Previous GC identifers: GC16P011842 GC16P012211 GC16P012025 GC16P011966


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF17:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed
in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been
shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and
to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may
transduce signals for cell survival and proliferation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNR17_HUMAN, Q02223
Function: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the
regulation of humoral immunity. Activates NF-kappa-B and JNK

Gene Wiki entry for TNFRSF17


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF17 gene promoter:
         HOXA9B   HOXA9   AP-1   ATF-2   MEF-2A   PPAR-gamma1   PPAR-gamma2   c-Jun   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFRSF17 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.1   Ensembl cytogenetic band:  16p13.13   HGNC cytogenetic band: 16p13.1

TNFRSF17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF17 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P012058:  view genomic region     (about GC identifiers)

Start:
12,058,964 bp from pter      End:
12,061,925 bp from pter
Size:
2,962 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TNR17_HUMAN, Q02223 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 17  
Size: 184 amino acids; 20165 Da
Subunit: Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6
Subcellular location: Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III
membrane protein. Note=Perinuclear Golgi-like structures
3 PDB 3D structures from and Proteopedia for TNFRSF17:
1OQD (3D)        1XU2 (3D)        2KN1 (3D)    

Explore the universe of human proteins at neXtProt for TNFRSF17: NX_Q02223

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q02223

  • TNFRSF17 Protein expression data from MOPED and PaxDb:    About this image 
    TNFRSF17 Protein Expression
    REFSEQ proteins: NP_001183.2  
    ENSEMBL proteins: 
     ENSP00000053243   ENSP00000379753   ENSP00000454314  

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    Sino Biological Recombinant Protein for TNFRSF17
    ProSpec Recombinant Protein for TNFRSF17
    Uscn Proteins for TNFRSF17

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0012505endomembrane system IEA--
    GO:0016021integral to membrane IEA--

    TNFRSF17 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TNFRSF17 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR015337 BCMA_Tall-1-bd
     IPR022320 TNFR_17

    Graphical View of Domain Structure for InterPro Entry Q02223

    ProtoNet protein and cluster: Q02223

    UniProtKB/Swiss-Prot: TNR17_HUMAN, Q02223
    Similarity: Contains 1 TNFR-Cys repeat


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR17_HUMAN, Q02223
    Function: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the
    regulation of humoral immunity. Activates NF-kappa-B and JNK

         Genatlas biochemistry entry for TNFRSF17:
    tumor necrosis factor receptor superfamily,member 17,B cell maturation gene,expressed in terminal stages of B cell
    differentiation,fused with IL2 in t(4;16)(q26;p13) translocation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS10908663
    GO:0005031tumor necrosis factor-activated receptor activity RCA19641626
         
    TNFRSF17 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TNFRSF17:
     Increased Salmonella enterica  

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tnfrsf17):
     hematopoietic system  immune system  normal 

    TNFRSF17 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Tnfrsf17tm1Kplm for TNFRSF17
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TNFRSF17 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF17


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TGF-Beta Pathway
    TGF-Beta Pathway1.00
    JNK Pathway0.50
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.29
    2PEDF Induced Signaling
    STAT3 Pathway0.47
    Glucocorticoid Receptor Signaling0.27
    NFAT Signaling and Lymphocyte Interactions0.37
    Cytokine-cytokine receptor interaction0.26
    PGC1Alpha Pathway0.33
    3Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway1.00
    Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway0.46
    Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway1.00
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway0.46
    4BAFF in B-Cell Signaling
    BAFF in B-Cell Signaling1.00
    Apoptosis and survival_APRIL and BAFF signaling0.39
    APRIL Pathway0.92
    Apoptosis and survival APRIL and BAFF signaling0.39
    5Akt Signaling
    Akt Signaling1.00
    Tec Kinases Signaling0.55
    p38 Signaling0.60

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for TNFRSF17
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival APRIL and BAFF signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

    1 R&D Systems Pathway for TNFRSF17
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    5/19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF17 (see all 19)
        TRAF Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    3 GeneGo (Thomson Reuters) Pathways for TNFRSF17
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival APRIL and BAFF signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway


    2         Kegg Pathways  (Kegg details for TNFRSF17):
        Cytokine-cytokine receptor interaction
    Intestinal immune network for IgA production


    TNFRSF17 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for TNFRSF17 (Q022233 ENSP000000532434) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFSF13O758883, ENSP000003435054I2D: score=1 STRING: ENSP00000343505
    TRAF5O004633, ENSP000002614644I2D: score=1 STRING: ENSP00000261464
    TNFSF13BQ9Y2753, ENSP000003650484I2D: score=4 STRING: ENSP00000365048
    TRAF1Q130773, ENSP000003629944I2D: score=3 STRING: ENSP00000362994
    TRAF2Q129333, ENSP000002476684I2D: score=3 STRING: ENSP00000247668
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS10908663
    GO:0007275multicellular organismal development TAS8165126
    GO:0008283cell proliferation TAS10908663
    GO:0033209tumor necrosis factor-mediated signaling pathway RCA19641626

    TNFRSF17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNFRSF17 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFRSF17
    3 Novoseek chemical compound relationships for TNFRSF17 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bcma 99.4 258 10903733 (9), 14764606 (8), 15697217 (8), 15692072 (8) (see all 88)
    blys 95.5 39 19175985 (3), 15697217 (2), 14512299 (2), 19909733 (2) (see all 21)
    calcium 3.69 9 17444957 (1), 14502235 (1), 15070697 (1), 15908449 (1) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about TNFRSF17 / TNR17 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNFRSF17 gene: 
    NM_001192.2  

    Unigene Cluster for TNFRSF17:

    Tumor necrosis factor receptor superfamily, member 17
    Hs.2556  [show with all ESTs]
    Unigene Representative Sequence: Z29575
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000053243(uc002dbv.3 uc010buy.3 uc010buz.3) ENST00000396495
    ENST00000562385

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    Additional cDNA sequence: 

    AY684975.1 BC058291.1 EF152353.1 EF152354.1 EF152355.1 EF152356.1 Z14954.1 Z29575.1 

    1 DOTS entry:

    DT.211555 

    21 AceView cDNA sequences:

    NM_001192 Z14954 Z29572 Z29575 BU945387 AA743176 AW139591 BG183381 
    CD693527 CD702387 BC058291 CD685587 BP428758 AA259026 AA633372 AA987627 
    BF223583 AA286871 Z14955 AI865358 CD685741 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFRSF17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTAAAGTCT
    TNFRSF17 Expression
    About this image
    See TNFRSF17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFRSF17

    SOURCE GeneReport for Unigene cluster: Hs.2556

    UniProtKB/Swiss-Prot: TNR17_HUMAN, Q02223
    Tissue specificity: Expressed in mature B-cells, but not in T-cells or monocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF17: 
              TNF Ligands & Receptors in human mouse rat
              Necrosis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for TNFRSF17 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf171 , 5 tumor necrosis factor receptor superfamily, member more1, 5 75.05(n)1
    65.92(a)1
      16 (6.42 cM)5
    219351  NM_011608.11  NP_035738.11 
     113138125 


    ENSEMBL Gene Tree for TNFRSF17 (if available)
    TreeFam Gene Tree for TNFRSF17 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/158 NCBI SNPs in TNFRSF17 are shown (see all 158    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1434931051,2
    --12057034(+) GAGTTC/TGAAAC 1 -- us2k10--------
    rs1909342771,2
    --12057054(+) CAACAC/TGGTGA 1 -- us2k10--------
    rs1439740351,2
    --12057120(+) TCATCC/TCAGCT 1 -- us2k10--------
    rs4515511,2
    --12057167(-) CTCCAC/TCTCCC 1 -- us2k10--------
    rs358107411,2
    C--12057238(+) AAAAAA/-AAAAA 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1819102491,2
    --12057347(+) AGAAAC/GTGTAA 1 -- us2k10--------
    rs129265351,2
    C,F,H--12057453(+) TTTTTG/ATGCTC 1 -- us2k110Minor allele frequency- A:0.15NS EA NA WA 644
    rs1411793671,2
    --12057521(+) CATTTC/TCTCAA 1 -- us2k10--------
    rs133326301,2
    C,F,H--12057558(+) CAAACA/CTCTGG 1 -- us2k126Minor allele frequency- C:0.05NS EA NA CSA 2746
    rs1507248391,2
    --12057565(+) CTGGAC/TGTCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TNFRSF17 (12058964 - 12061925 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TNFRSF17: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TNFRSF17 for disorders           About GeneDecksing

    OMIM gene information: 109545    OMIM disorders: --

    UniProtKB/Swiss-Prot: TNR17_HUMAN, Q02223
  • Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia
  • (T-ALL). Translocation t(4;16)(q26;p13) with IL2

    20/35 diseases for TNFRSF17 (see all 35):    About MalaCards
    blue cone monochromacy    b-cell non-hodgkin lymphoma    hypersensitivity reaction type ii disease    non-hodgkin lymphoma
    common variable immunodeficiency    waldenstrom macroglobulinemia    primary biliary cirrhosis    myasthenia gravis
    lupus erythematosus    hodgkin's lymphoma    b-cell lymphomas    chronic fatigue syndrome
    acquired immunodeficiency syndrome    systemic lupus erythematosus    macroglobulinemia    achromatopsia
    acute lymphoblastic leukemia    rheumatoid arthritis    chronic lymphocytic leukemia    multiple sclerosis

    10/13 Novoseek disease relationships for TNFRSF17 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 56.7 16 14764606 (2), 11960555 (2), 9846698 (1), 17499850 (1) (see all 13)
    autoimmune diseases 54.5 2 10908663 (1), 14764606 (1)
    myeloma 52.1 5 15692072 (2), 15070697 (1), 10903733 (1)
    leukemia lymphocytic chronic 42.6 1 19291294 (1)
    lupus erythematosus systemic 40.4 1 20097906 (1)
    tumors 40.2 15 14764606 (2), 15692072 (2), 9846698 (1), 15908449 (1) (see all 13)
    lymphoma 28.5 2 19321861 (1), 19403666 (1)
    lymphoma non-hodgkins 17 1 19291294 (1)
    lymphoma t-cell 15.9 2 9846698 (1), 8165126 (1)
    rheumatoid arthritis 4.05 1 17968879 (1)

    Genetic Association Database (GAD): TNFRSF17
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF17 (8 documents)

    Export disorders for TNFRSF17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFRSF17 gene, integrated from 9 sources (see all 126):
    (articles sorted by number of sources associating them with TNFRSF17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed. (PubMed id 8165126)1, 2, 3, 9 Laabi Y.... Tsapis A. (1994)
    2. Presence of four major haplotypes in human BCMA gene: lack of association with systemic lupus erythematosus and rheumatoid arthritis. (PubMed id 11528522)1, 2, 4 Kawasaki A.... Tokunaga K. (2001)
    3. A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma. (PubMed id 1396583)1, 2, 3 Laabi Y.... Tsapis A. (1992)
    4. TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen- activated protein kinase. (PubMed id 10903733)1, 2, 9 Hatzoglou A.... Tsapis A. (2000)
    5. B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. (PubMed id 10908663)1, 2, 9 Shu H.-B. and Johnson H. (2000)
    6. Ligand-receptor binding revealed by the TNF family member TALL-1. (PubMed id 12721620)1, 2, 9 Liu Y.... Zhang G. (2003)
    7. Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding. (PubMed id 15542592)1, 2 Hymowitz S.G....Starovasnik M.A. (2005)
    8. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. (PubMed id 10801128)1, 2 Gross J.A.... Clegg C.H. (2000)
    9. APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. (PubMed id 10973284)1, 2 Yu G.... Theill L.E. (2000)
    10. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 608 HGNC: 11913 AceView: TNFRSF17 Ensembl:ENSG00000048462 euGenes: HUgn608
    ECgene: TNFRSF17 Kegg: 608 H-InvDB: TNFRSF17

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFRSF17 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF17 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf17/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNFRSF17 gene:
    Search GeneIP for patents involving TNFRSF17

    GeneCards and IP:
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