Aliases for TNFRSF17 Gene
External Ids for TNFRSF17 Gene
Previous HGNC Symbols for TNFRSF17 Gene
Previous GeneCards Identifiers for TNFRSF17 Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF17 Gene
TNFRSF17 (Tumor Necrosis Factor Receptor Superfamily Member 17) is a Protein Coding gene. Diseases associated with TNFRSF17 include common variable immunodeficiency and chronic lymphocytic leukemia. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor activity.
UniProtKB/Swiss-Prot for TNFRSF17 Gene
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.