Aliases for TNFRSF17 Gene
External Ids for TNFRSF17 Gene
Previous HGNC Symbols for TNFRSF17 Gene
Previous GeneCards Identifiers for TNFRSF17 Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF17 Gene
TNFRSF17 (TNF Receptor Superfamily Member 17) is a Protein Coding gene. Diseases associated with TNFRSF17 include Common Variable Immunodeficiency and Chronic Lymphocytic Leukemia. Among its related pathways are RANK Signaling in Osteoclasts and Akt Signaling. GO annotations related to this gene include receptor activity.
UniProtKB/Swiss-Prot for TNFRSF17 Gene
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.