Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TNFRSF14 Gene

Aliases for TNFRSF14 Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 14 2 3
  • Tumor Necrosis Factor Receptor Superfamily, Member 14 (Herpesvirus Entry Mediator) 2 3
  • Herpes Virus Entry Mediator A 3 4
  • HVEA 3 4
  • HVEM 3 4
  • TR2 3 4
  • Tumor Necrosis Factor Receptor-Like Gene2 3
  • Tumor Necrosis Factor Receptor-Like 2 4
  • Herpesvirus Entry Mediator A 4
  • Herpesvirus Entry Mediator 2
  • CD40-Like Protein 3
  • CD270 Antigen 4
  • LIGHTR 3
  • CD270 3
  • ATAR 3

External Ids for TNFRSF14 Gene

Previous GeneCards Identifiers for TNFRSF14 Gene

  • GC01M002044
  • GC01M002502
  • GC01M002149
  • GC01M002358
  • GC01M002521
  • GC01P002487
  • GC01P001767

Summaries for TNFRSF14 Gene

Entrez Gene Summary for TNFRSF14 Gene

  • This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for TNFRSF14 Gene

TNFRSF14 (Tumor Necrosis Factor Receptor Superfamily, Member 14) is a Protein Coding gene. Diseases associated with TNFRSF14 include herpes simplex and follicular lymphoma. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include ubiquitin protein ligase binding and tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF11B.

UniProtKB/Swiss-Prot for TNFRSF14 Gene

  • Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.

  • (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 and herpes simplex virus 1/HHV-2.

Gene Wiki entry for TNFRSF14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF14 Gene

Genomics for TNFRSF14 Gene

Regulatory Elements for TNFRSF14 Gene

Genomic Location for TNFRSF14 Gene

Chromosome:
1
Start:
2,555,639 bp from pter
End:
2,565,622 bp from pter
Size:
9,984 bases
Orientation:
Plus strand

Genomic View for TNFRSF14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF14 Gene

Proteins for TNFRSF14 Gene

  • Protein details for TNFRSF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92956-TNR14_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 14
    Protein Accession:
    Q92956
    Secondary Accessions:
    • B3KW30
    • B9DI89
    • Q6IB95
    • Q8N634
    • Q8WXR1
    • Q96J31
    • Q9UM65

    Protein attributes for TNFRSF14 Gene

    Size:
    283 amino acids
    Molecular mass:
    30392 Da
    Quaternary structure:
    • Interacts with TRAF2, TRAF3 and TRAF5. (Microbial infection) Interacts with herpes simplex virus 1/HHV-1 and herpes simplex virus 1/HHV-2 envelope glycoprotein D (PubMed:11511370, PubMed:9696799).

    Three dimensional structures from OCA and Proteopedia for TNFRSF14 Gene

    Alternative splice isoforms for TNFRSF14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFRSF14 Gene

Proteomics data for TNFRSF14 Gene at MOPED

Post-translational modifications for TNFRSF14 Gene

Other Protein References for TNFRSF14 Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF14 (HVEM/TNFRSF14)
  • Cloud-Clone Corp. Antibodies for TNFRSF14

No data available for DME Specific Peptides for TNFRSF14 Gene

Domains & Families for TNFRSF14 Gene

Graphical View of Domain Structure for InterPro Entry

Q92956

UniProtKB/Swiss-Prot:

TNR14_HUMAN :
  • Contains 3 TNFR-Cys repeats.
Similarity:
  • Contains 3 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF14: view

Function for TNFRSF14 Gene

Molecular function for TNFRSF14 Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 14,widely expressed,involved in lymphocyte activation,homolog with 4-1BB (CD137)
UniProtKB/Swiss-Prot Function:
Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 and herpes simplex virus 1/HHV-2.

Gene Ontology (GO) - Molecular Function for TNFRSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005031 tumor necrosis factor-activated receptor activity TAS 9153189
GO:0005515 protein binding IPI 9153189
GO:0031625 ubiquitin protein ligase binding IPI 11279055
genes like me logo Genes that share ontologies with TNFRSF14: view
genes like me logo Genes that share phenotypes with TNFRSF14: view

Animal Models for TNFRSF14 Gene

MGI Knock Outs for TNFRSF14:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for TNFRSF14 Gene

Localization for TNFRSF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF14 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFRSF14 Gene COMPARTMENTS Subcellular localization image for TNFRSF14 gene
Compartment Confidence
plasma membrane 4
cytosol 2
cytoskeleton 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TNFRSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF14: view

Pathways & Interactions for TNFRSF14 Gene

genes like me logo Genes that share pathways with TNFRSF14: view

PCR Array Products

SIGNOR curated interactions for TNFRSF14 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TNFRSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002741 positive regulation of cytokine secretion involved in immune response IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response TAS 9162022
GO:0007166 cell surface receptor signaling pathway TAS 9153189
GO:0007275 multicellular organismal development IBA --
genes like me logo Genes that share ontologies with TNFRSF14: view

Drugs & Compounds for TNFRSF14 Gene

(3) Drugs for TNFRSF14 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
B and T lymphocyte attenuator Pharma 0
LIGHT Pharma 0
LYMPHOTOXIN-Α Pharma 0

(1) Additional Compounds for TNFRSF14 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
lymphotoxin-alpha
genes like me logo Genes that share compounds with TNFRSF14: view

Transcripts for TNFRSF14 Gene

Unigene Clusters for TNFRSF14 Gene

Tumor necrosis factor receptor superfamily, member 14:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF14 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - -
SP6: - -
SP7: - - - -
SP8: -
SP9: - - -
SP10: - - - -
SP11: - -
SP12: -

Relevant External Links for TNFRSF14 Gene

GeneLoc Exon Structure for
TNFRSF14
ECgene alternative splicing isoforms for
TNFRSF14

Expression for TNFRSF14 Gene

mRNA expression in normal human tissues for TNFRSF14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF14 Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for TNFRSF14 Gene

This gene is overexpressed in Adrenal (54.3) and Urine (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF14 Gene



SOURCE GeneReport for Unigene cluster for TNFRSF14 Gene Hs.512898

mRNA Expression by UniProt/SwissProt for TNFRSF14 Gene

Q92956-TNR14_HUMAN
Tissue specificity: Widely expressed, with the highest expression in lung, spleen and thymus
genes like me logo Genes that share expression patterns with TNFRSF14: view

Protein tissue co-expression partners for TNFRSF14 Gene

Primer Products

In Situ Assay Products

Orthologs for TNFRSF14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF14 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TNFRSF14 35
  • 68.73 (n)
  • 58.53 (a)
TNFRSF14 36
  • 49 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnfrsf14 35
  • 61.18 (n)
  • 47.19 (a)
Tnfrsf14 16
Tnfrsf14 36
  • 41 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF14 35
  • 98.82 (n)
  • 98.23 (a)
TNFRSF14 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfrsf14 35
  • 59.38 (n)
  • 43.72 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia TNFRSF14 36
  • 27 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733953 35
  • 43.82 (n)
  • 38.99 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-23c22.5 35
  • 45.07 (n)
  • 38.78 (a)
TNFRSF14 (1 of 12) 36
  • 24 (a)
OneToMany
TNFRSF14 (10 of 12) 36
  • 25 (a)
OneToMany
TNFRSF14 (11 of 12) 36
  • 36 (a)
OneToMany
TNFRSF14 (12 of 12) 36
  • 28 (a)
OneToMany
TNFRSF14 (2 of 12) 36
  • 24 (a)
OneToMany
TNFRSF14 (3 of 12) 36
  • 24 (a)
OneToMany
TNFRSF14 (4 of 12) 36
  • 23 (a)
OneToMany
TNFRSF14 (5 of 12) 36
  • 26 (a)
OneToMany
TNFRSF14 (6 of 12) 36
  • 19 (a)
OneToMany
TNFRSF14 (7 of 12) 36
  • 27 (a)
OneToMany
TNFRSF14 (8 of 12) 36
  • 24 (a)
OneToMany
TNFRSF14 (9 of 12) 36
  • 30 (a)
OneToMany
Species with no ortholog for TNFRSF14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF14 Gene

ENSEMBL:
Gene Tree for TNFRSF14 (if available)
TreeFam:
Gene Tree for TNFRSF14 (if available)

Paralogs for TNFRSF14 Gene

Paralogs for TNFRSF14 Gene

genes like me logo Genes that share paralogs with TNFRSF14: view

Variants for TNFRSF14 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF14 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8725 -- 2,563,346(+) TGGCG(A/C/G/T)AACCA utr-variant-3-prime, nc-transcript-variant
rs1055584 -- 2,563,729(+) ATTTT(C/T)TAAAT utr-variant-3-prime, nc-transcript-variant
rs1801297 -- 2,563,476(+) AGTGA(A/G)GGCCT utr-variant-3-prime, nc-transcript-variant
rs2234160 untested 2,559,725(+) AGGGC(A/G)CCCTG intron-variant, utr-variant-5-prime, nc-transcript-variant
rs2234161 untested 2,559,766(+) TGGCC(C/T)GTGGA intron-variant, reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF14 Gene

Variant ID Type Subtype PubMed ID
dgv64n71 CNV Loss 21882294
dgv71n71 CNV Loss 21882294
dgv75n71 CNV Loss 21882294
nsv470684 CNV Loss 18288195
dgv79n71 CNV Loss 21882294
nsv871726 CNV Loss 21882294
nsv870655 CNV Loss 21882294
nsv7171 OTHER Inversion 18451855
nsv436691 OTHER Inversion 17901297
dgv1n47 OTHER Inversion 21111241
dgv1n50 OTHER Inversion 21212237
esv1699286 OTHER Inversion 17803354
esv2471749 OTHER Inversion 19546169
nsv824475 CNV Loss 20364138
nsv824364 CNV Loss 20364138

Variation tolerance for TNFRSF14 Gene

Residual Variation Intolerance Score: 58.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF14 Gene

HapMap Linkage Disequilibrium report
TNFRSF14
Human Gene Mutation Database (HGMD)
TNFRSF14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF14 Gene

Disorders for TNFRSF14 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TNFRSF14 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
follicular lymphoma
  • lymphoma, follicular
bone inflammation disease
  • bone inflammatory disease
- elite association

Relevant External Links for TNFRSF14

Genetic Association Database (GAD)
TNFRSF14
Human Genome Epidemiology (HuGE) Navigator
TNFRSF14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFRSF14
genes like me logo Genes that share disorders with TNFRSF14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF14 Gene

Publications for TNFRSF14 Gene

  1. A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation. (PMID: 9162061) Kwon B.S. … Young P.R. (J. Biol. Chem. 1997) 2 23 67
  2. Interaction of T-cell and antigen presenting cell co-stimulatory genes in childhood IgE. (PMID: 19574333) Bottema R.W. … Kerkhof M. (Eur. Respir. J. 2010) 23 67
  3. Cosignaling molecules around LIGHT-HVEM-BTLA: from immune activation to therapeutic targeting. (PMID: 19860669) Pasero C. … Olive D. (Curr. Mol. Med. 2009) 23 67
  4. Role of nectin-1, HVEM, and PILR-alpha in HSV-2 entry into human retinal pigment epithelial cells. (PMID: 19234349) Shukla S.Y. … Shukla D. (Invest. Ophthalmol. Vis. Sci. 2009) 23 67
  5. T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment. (PMID: 19915044) Cheung T.C. … Ware C.F. (J. Immunol. 2009) 23 67

Products for TNFRSF14 Gene

Sources for TNFRSF14 Gene

Back to Top

Content