Aliases for TNFRSF14 Gene
- TNF Receptor Superfamily Member 14 2 3 5
- Tumor Necrosis Factor Receptor Superfamily, Member 14 (Herpesvirus Entry Mediator) 2 3
- Herpes Virus Entry Mediator A 3 4
- HVEA 3 4
- HVEM 3 4
- TR2 3 4
- Tumor Necrosis Factor Receptor Superfamily, Member 14 2
- Tumor Necrosis Factor Receptor Superfamily Member 14 3
- Tumor Necrosis Factor Receptor-Like Gene2 3
External Ids for TNFRSF14 Gene
Previous GeneCards Identifiers for TNFRSF14 Gene
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for TNFRSF14 Gene
TNFRSF14 (TNF Receptor Superfamily Member 14) is a Protein Coding gene. Diseases associated with TNFRSF14 include Herpes Simplex and Cleft Lip/Palate-Ectodermal Dysplasia Syndrome. Among its related pathways are Cytokine Signaling in Immune system and Akt Signaling. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF1B.
UniProtKB/Swiss-Prot for TNFRSF14 Gene
Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 and herpes simplex virus 1/HHV-2.