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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF14 Gene

protein-coding   GIFtS: 62
GCID: GC01P002487

tumor necrosis factor receptor superfamily, member 14

(Previous names: tumor necrosis factor receptor superfamily, member 14 (herpesvirus...)
 Explore 21 diseases affiliated with
TNFRSF14 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TNFRSF14    

Aliases
for TNFRSF14 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 141 2     Herpes Virus Entry Mediator A2 3
HVEM1 2 3 5     Herpesvirus Entry Mediator A2 3
TR21 2 3 5     Tumor Necrosis Factor Receptor-Like 22 3
HVEA1 2 3     CD40-Like Protein2
ATAR1 2     Tumor Necrosis Factor Receptor Superfamily Member 142
CD2701 2     Tumor Necrosis Factor Receptor-Like Gene22
LIGHTR1 2     HveA3
Tumor Necrosis Factor Receptor Superfamily, Member 14 (Herpesvirus Entry
Mediator)1 2
     CD270 Antigen3

External Ids:    HGNC: 119121   Entrez Gene: 87642   Ensembl: ENSG000001578737   OMIM: 6027465   UniProtKB: Q929563   

Export aliases for TNFRSF14 gene to outside databases

Previous GC identifers: GC01M002044 GC01M002502 GC01M002149 GC01M002358 GC01M002521 GC01P001767


Summaries
for TNFRSF14 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TNFRSF14:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a
cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this
receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was
found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the
immune response. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNR14_HUMAN, Q92956
Function: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in
lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type
HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells

Gene Wiki entry for TNFRSF14


Genomic Views
for TNFRSF14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF14 gene promoter:
         RP58   Tal-1   Nkx2-5   Nkx5-1   E47   GATA-1   AREB6   E2F   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNFRSF14 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.32   Ensembl cytogenetic band:  1p36.32   HGNC cytogenetic band: 1p36.32

TNFRSF14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF14 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P002487:  view genomic region     (about GC identifiers)

Start:
 2,487,078 bp from pter      End:
 2,497,061 bp from pter
Size:
 9,984 bases      Orientation:
 plus strand

Proteins
for TNFRSF14 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TNR14_HUMAN, Q92956 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 14 precursor  
Size: 283 amino acids; 30392 Da
Subunit: Interacts with TRAF2, TRAF3 and TRAF5. Interacts with herpes simplex virus 1 (HHV-1) and herpes simplex virus
1 (HHV-2) envelope glycoprotein D; functions as an entry receptor for these viruses
Subcellular location: Membrane; Single-pass type I membrane protein (Probable)
3 PDB 3D structures from and Proteopedia for TNFRSF14:
1JMA (3D)        2AW2 (3D)        4FHQ (3D)    
Secondary accessions: B9DI89 Q6IB95 Q8WXR1 Q96J31 Q9UM65

Explore the universe of human proteins at neXtProt for TNFRSF14: NX_Q92956

Post-translational modifications:

  • N-glycosylated1
  • View neXtProt modification sites for NX_Q92956

    • TNFRSF14 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003811.2  
    ENSEMBL proteins: 
     ENSP00000411854   ENSP00000415254   ENSP00000399292   ENSP00000399533   ENSP00000386859  
     ENSP00000347948   ENSP00000405172   ENSP00000462604  
    Reactome Protein details: Q92956
    Human Recombinant Protein Products: 
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    Novus Biologicals TNFRSF14 Lysates
    Sino Biological Recombinant Protein for TNFRSF14
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TNFRSF14

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IC9153189
    GO:0009897external side of plasma membrane IEA--


    TNFRSF14 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TNFRSF14 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TNFRSF14 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR022332 TNFR_14

    Graphical View of Domain Structure for InterPro Entry Q92956

    ProtoNet protein and cluster: Q92956

    2 Blocks protein families:
    IPB001368 TNFR/CD27/30/40/95 cysteine-rich region
    IPB008063 FAS/CD95 receptor family signature


    UniProtKB/Swiss-Prot: TNR14_HUMAN, Q92956
    Similarity: Contains 3 TNFR-Cys repeats


    Function
    for TNFRSF14 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TNR14_HUMAN, Q92956
    Function: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in
    lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type
    HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells

         Genatlas biochemistry entry for TNFRSF14:
    tumor necrosis factor receptor superfamily,member 14,widely expressed,involved in lymphocyte activation,homolog with
    4-1BB (CD137)

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005031tumor necrosis factor-activated receptor activity TAS9153189
    GO:0005515protein binding IPI10318773
    GO:0031625ubiquitin protein ligase binding IPI11279055


    TNFRSF14 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TNFRSF14:
     Decreased cell number, increas 

    Animal Models:
         Mouse knock-outs for TNFRSF14: Tnfrsf14tm1Csj Tnfrsf14tm1Kpf
         6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tnfrsf14):
     cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging 

    TNFRSF14 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TNFRSF14 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    3PEDF Induced Signaling
    		STAT3 Pathway0.47
    		Cytokine-cytokine receptor interaction0.26
    4TRAF Pathway
    		TNF Superfamily Pathway0.42
    		TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.08
    5PAK Pathway
    		Antioxidant Action of Vitamin-C0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for TNFRSF14
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF14 (see all 7)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling

    3        Reactome Pathways for TNFRSF14
        Costimulation by the CD28 family
    Adaptive Immune System
    Immune System


    1         Kegg Pathway  (Kegg details for TNFRSF14):
        Cytokine-cytokine receptor interaction


    TNFRSF14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/107 Interacting proteins for TNFRSF14 (Q929561, 2, 3 ENSP000003479484) via UniProtKB, MINT, STRING, and/or I2D (see all 107)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFSF14O435571, 3, ENSP000002459124EBI-1056653,EBI-524131 I2D: score=4 STRING: ENSP00000245912
    TRAF5O004631, 3, ENSP000002614644EBI-1056653,EBI-523498 I2D: score=4 STRING: ENSP00000261464
    DGKDQ167602, 3, ENSP000002640574MINT-8274467 I2D: score=2 STRING: ENSP00000264057
    DRAP1Q149192, 3, ENSP000003078504MINT-8274478 I2D: score=2 STRING: ENSP00000307850
    IMPA2O147322, 3, ENSP000002691594MINT-8274500 I2D: score=2 STRING: ENSP00000269159
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS9162022
    GO:0007166cell surface receptor signaling pathway TAS9153189
    GO:0019048virus-host interaction IEA--
    GO:0031295T cell costimulation TAS--
    GO:0033209tumor necrosis factor-mediated signaling pathway TAS9153189


    TNFRSF14 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TNFRSF14 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFRSF14
    Search CenterWatch for drugs/clinical trials and news about TNFRSF14 / TNR14 

    Transcripts
    for TNFRSF14 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TNFRSF14 gene: 
    NM_003820.2  

    Unigene Cluster for TNFRSF14:

    Tumor necrosis factor receptor superfamily, member 14
    Hs.512898  [show with all ESTs]
    Unigene Representative Sequence: AB208808
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426449 ENST00000434817 ENST00000435221 ENST00000451778 ENST00000409119
    ENST00000355716(uc001ajr.3) ENST00000475523 ENST00000442392(uc010nzc.1)
    ENST00000482074 ENST00000496064(uc009vlf.1) ENST00000463471(uc001ajt.1)
    ENST00000466750 ENST00000471768 ENST00000463835 ENST00000482602 ENST00000480305


    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB208808.1 AF153978.1 AF373877.1 AF373878.1 AK124010.1 AK130172.1 AK300515.1 AK303468.1 
    AK310076.1 AY358879.1 BC002794.2 BC018882.2 BC029848.1 CR456909.1 U70321.1 U81232.1 

    17 DOTS entries:

    DT.447822  DT.100750189  DT.75164844  DT.95160381  DT.100873025  DT.95160367  DT.95318517  DT.95160377 
    DT.95160386  DT.95210574  DT.97797648  DT.100758999  DT.100841233  DT.121411968  DT.95160385  DT.100743544 
    DT.91709377 

    24/292 AceView cDNA sequences (see all 292):

    BQ446850 BQ719775 AI184904 AA844171 CR625233 BI824375 BX436515 CB529369 
    AI801704 CD366981 BU191703 BM987791 BM784241 CR598295 CR615544 BM818970 
    AI285507 CA389382 BM852140 BF725912 CR622712 NM_003820 AI272861 BM928475 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF14 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11
    SP1:        -     -     -           -                 -     -     -           -           -                                 
    SP2:                    -           -                 -     -     -           -           -                                 
    SP3:                                -                 -     -     -           -           -                       -         
    SP4:                                -                 -     -     -           -                                             
    SP5:                                -                 -     -     -           -           -     -     -     -     -         


    ECgene alternative splicing isoforms for TNFRSF14

    Expression
    for TNFRSF14 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFRSF14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAACAGTGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TNFRSF14 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)

    See TNFRSF14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFRSF14

    SOURCE GeneReport for Unigene cluster: Hs.512898

    UniProtKB/Swiss-Prot: TNR14_HUMAN, Q92956
    Tissue specificity: Widely expressed, with the highest expression in lung, spleen and thymus

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF14: 
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              Necrosis in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for TNFRSF14 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF14 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7958581 tumor necrosis factor receptor superfamily member 14-like less 47.92(n)
    39.58(a)    		   795858  XM_001336090.3  XP_001336126.3 


    ENSEMBL Gene Tree for TNFRSF14 (if available)
    TreeFam Gene Tree for TNFRSF14 (if available) 

    Paralogs
    for TNFRSF14 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFRSF14 gene
    TNFRSF212  TNFRSF6B2  CD402  TNFRSF1B2  TNFRSF42  TNFRSF11A2  NGFR2  TNFRSF11B2  
    LTBR2  TNFRSF92  

    TNFRSF14 for paralogs           About GeneDecksing



    Genomic Variants
    for TNFRSF14 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/202 NCBI SNPs in TNFRSF14 are shown (see all 202)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs773673061,2
    		--2485821(-) CTCCCA/GGGCAG 2 -- us2k12Minor allele frequency- G:0.33CSA 3
    rs1898345951,2
    		--2486102(+) GGGAGC/TTGAAG 2 -- us2k10--------
    rs37624401,2
    		C,F,H,--2486110(-) TACCCC/TGACTT 2 -- us2k111Minor allele frequency- T:0.06NS EA 1258
    rs1823066611,2
    		--2486113(+) TCGGGA/GTAGGA 2 -- us2k10--------
    rs37624391,2
    		F--2486268(-) GGTACG/AGGGCT 2 -- us2k11Minor allele frequency- A:0.01EA 1482
    rs1870089561,2
    		--2486489(+) TGTGAA/GTGCAC 1 -- us2k10--------
    rs37624381,2
    		C,F,--2486868(-) ATTGCG/ACCCAC 2 -- us2k1 ds50017Minor allele frequency- A:0.24NS 842
    rs22341481,2
    		C,F,--2487071(+) CAGAGC/G/TGGGTG 2 -- ds5001 us2k11NS 180
    rs22341491,2
    		--2487286(+) CATCCA/GGAGGT 2 -- us2k1 nc-transcript-variant0--------
    rs1833146051,2
    		--2487294(+) GGTCTC/TCCTAC 2 -- nc-transcript-variantus2k10--------

    HapMap Linkage Disequilibrium report for TNFRSF14 (2487078 - 2497061 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for TNFRSF14
         2 CNVs: 29820 29817
         2 Inversions: 29446 103304

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    Disorders / Diseases
    for TNFRSF14 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TNFRSF14 for disorders           About GeneDecksing

    OMIM gene information: 602746    OMIM disorders: --

    20/21 diseases for TNFRSF14 (see all 21):    About MalaCards
    herpes simplex    systemic lupus erythematosus    lupus erythematosus    rheumatoid arthritis
    follicular lymphoma    alcoholic hepatitis    celiac disease    multiple myeloma
    multiple sclerosis    atopy    hepatitis b    arthritis
    conjunctivitis    myeloma    pertussis    alcoholism
    hepatitis    obesity    retinitis    melanoma

    6 Novoseek disease relationships for TNFRSF14 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 74.4 18 11119586 (2), 9657005 (1), 19915044 (1), 11511354 (1) (see all 12)
    herpes 51.6 2 19426226 (1), 11164894 (1)
    necrosis 45.2 13 11742877 (1), 9153189 (1), 11976496 (1), 12466117 (1) (see all 11)
    tumors 25.4 16 11742877 (1), 9153189 (1), 11976496 (1), 12466117 (1) (see all 12)
    atherosclerotic plaque 22.4 1 15667572 (1)
    rheumatoid arthritis 0 1 17393389 (1)

    Human Genome Epidemiology (HuGE) Navigator: TNFRSF14 (20 documents)

    Export disorders for TNFRSF14 gene to outside databases

    Publications
    for TNFRSF14 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFRSF14 gene, integrated from 9 sources (see all 113):
    (articles sorted by number of sources associating them with TNFRSF14)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation. (PubMed id 9162061)1, 2, 3, 9 Kwon B.S.... Young P.R. (1997)
    2. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. (PubMed id 8898196)1, 2, 3 Montgomery R.I.... Spear P.G. (1996)
    3. ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. (PubMed id 9153189)1, 2, 9 Hsu H.... Boyle W.J. (1997)
    4. Search for polymorphisms in the genes for herpesvirus entry mediator, Nectin-1, and Nectin-2 in immune seronegative individuals. (PubMed id 11756979)1, 2, 9 Struyf F....Spear P.G. (2002)
    5. Attenuating lymphocyte activity: the crystal structure of the BTLA- HVEM complex. (PubMed id 16169851)1, 2 Compaan D.M....Hymowitz S.G. (2005)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. Herpes simplex virus glycoprotein D bound to the human receptor HveA. (PubMed id 11511370)1, 2 Carfi A.... Wiley D.C. (2001)
    10. Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. (PubMed id 9162022)1, 2 Marsters S.A....Ashkenazi A. (1997)

    External Searches for TNFRSF14 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TNFRSF14 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8764 HGNC: 11912 AceView: TNFRSF14 Ensembl:ENSG00000157873 euGenes: HUgn8764
    ECgene: TNFRSF14 Kegg: 8764 H-InvDB: TNFRSF14

    Other Databases showing TNFRSF14 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TNFRSF14 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFRSF14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF14 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf14/

    Intellectual Property
    for TNFRSF14 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TNFRSF14 gene:
    Search GeneIP for patents involving TNFRSF14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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