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Aliases for TNFRSF14 Gene

Aliases for TNFRSF14 Gene

  • TNF Receptor Superfamily Member 14 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 14 (Herpesvirus Entry Mediator) 2 3
  • Herpes Virus Entry Mediator A 3 4
  • HVEA 3 4
  • HVEM 3 4
  • TR2 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 14 2
  • Tumor Necrosis Factor Receptor Superfamily Member 14 3
  • Tumor Necrosis Factor Receptor-Like Gene2 3
  • Tumor Necrosis Factor Receptor-Like 2 4
  • Herpesvirus Entry Mediator A 4
  • Herpesvirus Entry Mediator 2
  • CD40-Like Protein 3
  • CD270 Antigen 4
  • LIGHTR 3
  • CD270 3
  • ATAR 3

External Ids for TNFRSF14 Gene

Previous GeneCards Identifiers for TNFRSF14 Gene

  • GC01M002044
  • GC01M002502
  • GC01M002149
  • GC01M002358
  • GC01M002521
  • GC01P002487
  • GC01P001767

Summaries for TNFRSF14 Gene

Entrez Gene Summary for TNFRSF14 Gene

  • This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for TNFRSF14 Gene

TNFRSF14 (TNF Receptor Superfamily Member 14) is a Protein Coding gene. Diseases associated with TNFRSF14 include Herpes Simplex and Cleft Lip/Palate-Ectodermal Dysplasia Syndrome. Among its related pathways are TRAF Pathway and Innate Immune System. GO annotations related to this gene include ubiquitin protein ligase binding and tumor necrosis factor-activated receptor activity. An important paralog of this gene is LTBR.

UniProtKB/Swiss-Prot for TNFRSF14 Gene

  • Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.

  • (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 and herpes simplex virus 1/HHV-2.

Gene Wiki entry for TNFRSF14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF14 Gene

Genomics for TNFRSF14 Gene

Regulatory Elements for TNFRSF14 Gene

Enhancers for TNFRSF14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G002574 2 FANTOM5 Ensembl ENCODE dbSUPER 14 +21.3 21343 5.2 HDGF PKNOX1 FOXA2 MLX AGO1 ARID4B DMAP1 YY1 ZNF143 ZNF207 MMEL1 TNFRSF14 FAM213B SKI GC01M002574
GH01G002543 1.8 FANTOM5 ENCODE dbSUPER 12.7 -8.6 -8553 7.5 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MORN1 MMEL1 LOC100129381 LOC100288379 TNFRSF14 LOC100129534 SLC35E2 MIB2 SLC35E2B FAM213B
GH01G002245 1.9 FANTOM5 Ensembl ENCODE dbSUPER 7 -306.5 -306528 6.6 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 YY1 CBX5 MORN1 LOC100129534 LINC01786 ENSG00000240731 ENSG00000272455 SLC35E2 MIB2 CCNL2 SLC35E2B LOC100129381
GH01G002298 2 FANTOM5 Ensembl ENCODE dbSUPER 5.7 -254.8 -254830 4.3 HDGF FOXA2 PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 FEZF1 YY1 SKI LOC100129534 MORN1 ENSG00000272455 ENSG00000240731 SLC35E2 MIB2 PUSL1 CCNL2 SLC35E2B
GH01G002239 1.6 FANTOM5 Ensembl ENCODE dbSUPER 3.9 -315.3 -315291 1.3 KLF1 NFIB SIN3A MAX ZIC2 RAD21 ZFHX2 GLIS2 EGR1 PATZ1 NADK SKI TNFRSF14 GNB1 PANK4 PIR45792
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFRSF14 on UCSC Golden Path with GeneCards custom track

Promoters for TNFRSF14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000000368 961 1601 HDGF MLX WRNIP1 ARID4B DMAP1 ZNF48 YY1 ZNF766 GLIS2 GATA2

Genomic Location for TNFRSF14 Gene

Chromosome:
1
Start:
2,555,639 bp from pter
End:
2,565,622 bp from pter
Size:
9,984 bases
Orientation:
Plus strand

Genomic View for TNFRSF14 Gene

Genes around TNFRSF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF14 Gene

Proteins for TNFRSF14 Gene

  • Protein details for TNFRSF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92956-TNR14_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 14
    Protein Accession:
    Q92956
    Secondary Accessions:
    • B3KW30
    • B9DI89
    • Q6IB95
    • Q8N634
    • Q8WXR1
    • Q96J31
    • Q9UM65

    Protein attributes for TNFRSF14 Gene

    Size:
    283 amino acids
    Molecular mass:
    30392 Da
    Quaternary structure:
    • Interacts with TRAF2, TRAF3 and TRAF5.
    • (Microbial infection) Interacts with herpes simplex virus 1/HHV-1 and herpes simplex virus 1/HHV-2 envelope glycoprotein D (PubMed:11511370, PubMed:9696799).

    Three dimensional structures from OCA and Proteopedia for TNFRSF14 Gene

    Alternative splice isoforms for TNFRSF14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFRSF14 Gene

Post-translational modifications for TNFRSF14 Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF14 (HVEM/TNFRSF14)

Assay Products

  • Abcam assays for TNFRSF14

No data available for DME Specific Peptides for TNFRSF14 Gene

Domains & Families for TNFRSF14 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFRSF14: view

No data available for UniProtKB/Swiss-Prot for TNFRSF14 Gene

Function for TNFRSF14 Gene

Molecular function for TNFRSF14 Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 14,widely expressed,involved in lymphocyte activation,homolog with 4-1BB (CD137)
UniProtKB/Swiss-Prot Function:
Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 and herpes simplex virus 1/HHV-2.

Gene Ontology (GO) - Molecular Function for TNFRSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005031 tumor necrosis factor-activated receptor activity TAS 9153189
GO:0005515 protein binding IPI 9153189
GO:0031625 ubiquitin protein ligase binding IPI 11279055
genes like me logo Genes that share ontologies with TNFRSF14: view
genes like me logo Genes that share phenotypes with TNFRSF14: view

Animal Models for TNFRSF14 Gene

MGI Knock Outs for TNFRSF14:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TNFRSF14 Gene

Localization for TNFRSF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF14 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF14 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 3
cytoskeleton 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TNFRSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA,IC --
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF14: view

Pathways & Interactions for TNFRSF14 Gene

genes like me logo Genes that share pathways with TNFRSF14: view

SIGNOR curated interactions for TNFRSF14 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TNFRSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002741 positive regulation of cytokine secretion involved in immune response IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response TAS 9162022
GO:0007166 cell surface receptor signaling pathway TAS 9153189
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with TNFRSF14: view

Drugs & Compounds for TNFRSF14 Gene

(3) Drugs for TNFRSF14 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
B and T lymphocyte attenuator Pharma 0
LIGHT Pharma 0
LYMPHOTOXIN-Α Pharma 0

(1) Additional Compounds for TNFRSF14 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
lymphotoxin-alpha
genes like me logo Genes that share compounds with TNFRSF14: view

Transcripts for TNFRSF14 Gene

Unigene Clusters for TNFRSF14 Gene

Tumor necrosis factor receptor superfamily, member 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF14 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - -
SP6: - -
SP7: - - - -
SP8: -
SP9: - - -
SP10: - - - -
SP11: - -
SP12: -

Relevant External Links for TNFRSF14 Gene

GeneLoc Exon Structure for
TNFRSF14
ECgene alternative splicing isoforms for
TNFRSF14

Expression for TNFRSF14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF14 Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for TNFRSF14 Gene

This gene is overexpressed in Adrenal (54.3) and Urine (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF14 Gene



Protein tissue co-expression partners for TNFRSF14 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF14 Gene:

TNFRSF14

SOURCE GeneReport for Unigene cluster for TNFRSF14 Gene:

Hs.512898

mRNA Expression by UniProt/SwissProt for TNFRSF14 Gene:

Q92956-TNR14_HUMAN
Tissue specificity: Widely expressed, with the highest expression in lung, spleen and thymus.

Evidence on tissue expression from TISSUES for TNFRSF14 Gene

  • Skin(4.7)
  • Spleen(4.6)
  • Liver(4.2)
  • Lymph node(3)
  • Blood(2.7)
  • Intestine(2.3)
  • Bone marrow(2.2)
  • Eye(2.2)
  • Kidney(2.1)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with TNFRSF14: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF14 Gene

Orthologs for TNFRSF14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF14 34 35
  • 98.82 (n)
dog
(Canis familiaris)
Mammalia TNFRSF14 34 35
  • 68.73 (n)
mouse
(Mus musculus)
Mammalia Tnfrsf14 34 16 35
  • 61.18 (n)
rat
(Rattus norvegicus)
Mammalia Tnfrsf14 34
  • 59.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 26 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia TNFRSF14 35
  • 27 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733953 34
  • 43.82 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-23c22.5 34
  • 45.07 (n)
TNFRSF14 (11 of 12) 35
  • 36 (a)
OneToMany
TNFRSF14 (9 of 12) 35
  • 30 (a)
OneToMany
TNFRSF14 (12 of 12) 35
  • 28 (a)
OneToMany
TNFRSF14 (7 of 12) 35
  • 27 (a)
OneToMany
TNFRSF14 (5 of 12) 35
  • 26 (a)
OneToMany
TNFRSF14 (10 of 12) 35
  • 25 (a)
OneToMany
TNFRSF14 (1 of 12) 35
  • 24 (a)
OneToMany
TNFRSF14 (2 of 12) 35
  • 24 (a)
OneToMany
TNFRSF14 (3 of 12) 35
  • 24 (a)
OneToMany
TNFRSF14 (8 of 12) 35
  • 24 (a)
OneToMany
TNFRSF14 (4 of 12) 35
  • 23 (a)
OneToMany
TNFRSF14 (6 of 12) 35
  • 19 (a)
OneToMany
Species where no ortholog for TNFRSF14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF14 Gene

ENSEMBL:
Gene Tree for TNFRSF14 (if available)
TreeFam:
Gene Tree for TNFRSF14 (if available)

Paralogs for TNFRSF14 Gene

Paralogs for TNFRSF14 Gene

genes like me logo Genes that share paralogs with TNFRSF14: view

Variants for TNFRSF14 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF14 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs386352373 Uncertain significance 2,561,679(+) TGCAG(C/G)TGGCT intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime
rs112070015 untested 2,559,622(-) AGCTG(C/T)GTGTG intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs11573975 untested 2,559,013(+) CCATG(A/C/T)GGCCA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs11573976 untested 2,559,074(+) CCCTG(C/G/T)GGCCA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs11573986 untested 2,560,684(+) CAATG(A/G)GACCC nc-transcript-variant, reference, missense, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF14 Gene

Variant ID Type Subtype PubMed ID
dgv1n47 OTHER inversion 21111241
dgv1n50 OTHER inversion 21212237
dgv5n67 CNV loss 20364138
esv1699286 OTHER inversion 17803354
esv2471749 OTHER inversion 19546169
esv3447351 OTHER inversion 20981092
nsv436691 OTHER inversion 17901297
nsv470684 CNV loss 18288195
nsv545077 CNV gain 21841781
nsv545082 CNV loss 21841781
nsv7171 OTHER inversion 18451855
nsv824364 CNV loss 20364138
nsv824475 CNV loss 20364138
nsv951557 CNV deletion 24416366
nsv951592 CNV deletion 24416366

Variation tolerance for TNFRSF14 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF14 Gene

Human Gene Mutation Database (HGMD)
TNFRSF14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF14 Gene

Disorders for TNFRSF14 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TNFRSF14 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
cleft lip/palate-ectodermal dysplasia syndrome
  • orofacial cleft 7
acute retinal necrosis syndrome
  • acute retinal necrosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFRSF14

Genetic Association Database (GAD)
TNFRSF14
Human Genome Epidemiology (HuGE) Navigator
TNFRSF14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFRSF14
genes like me logo Genes that share disorders with TNFRSF14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF14 Gene

Publications for TNFRSF14 Gene

  1. A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation. (PMID: 9162061) Kwon B.S. … Young P.R. (J. Biol. Chem. 1997) 2 3 4 22 64
  2. Search for polymorphisms in the genes for herpesvirus entry mediator, Nectin-1, and Nectin-2 in immune seronegative individuals. (PMID: 11756979) Struyf F. … Spear P.G. (J. Infect. Dis. 2002) 3 4 22 64
  3. ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. (PMID: 9153189) Hsu H. … Boyle W.J. (J. Biol. Chem. 1997) 3 4 22 64
  4. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. (PMID: 8898196) Montgomery R.I. … Spear P.G. (Cell 1996) 2 3 4 64
  5. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson C.A. … Rioux J.D. (Nat. Genet. 2011) 3 46 64

Products for TNFRSF14 Gene

Sources for TNFRSF14 Gene

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