Aliases for TNFRSF14 Gene
External Ids for TNFRSF14 Gene
Previous GeneCards Identifiers for TNFRSF14 Gene
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for TNFRSF14 Gene
TNFRSF14 (Tumor Necrosis Factor Receptor Superfamily, Member 14) is a Protein Coding gene. Diseases associated with TNFRSF14 include herpes simplex and follicular lymphoma. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include ubiquitin protein ligase binding and tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF11B.
UniProtKB/Swiss-Prot for TNFRSF14 Gene
Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 and herpes simplex virus 1/HHV-2.