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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF14 Gene

protein-coding   GIFtS: 65
GCID: GC01P002487

Tumor Necrosis Factor Receptor Superfamily, Member 14

(Previous names: tumor necrosis factor receptor superfamily, member 14 (herpesvirus...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 141 2     ATAR2
HVEM2 3 5     CD2702
TR22 3 5     LIGHTR2
Tumor Necrosis Factor Receptor Superfamily, Member 14 (Herpesvirus Entry
Mediator)1 2
     CD40-Like Protein2
Herpes Virus Entry Mediator A2 3     Tumor Necrosis Factor Receptor Superfamily Member 142
Herpesvirus Entry Mediator A2 3     Tumor Necrosis Factor Receptor-Like Gene22
Tumor Necrosis Factor Receptor-Like 22 3     HveA3
HVEA2 3     CD270 Antigen3
Herpesvirus Entry Mediator1     

External Ids:    HGNC: 119121   Entrez Gene: 87642   Ensembl: ENSG000001578737   OMIM: 6027465   UniProtKB: Q929563   

Export aliases for TNFRSF14 gene to outside databases

Previous GC identifers: GC01M002044 GC01M002502 GC01M002149 GC01M002358 GC01M002521 GC01P001767


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF14 Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a
cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this
receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor
was found to bind to several TRAF family members, which may mediate the signal transduction pathways that
activate the immune response. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFRSF14 Gene: 
TNFRSF14 (tumor necrosis factor receptor superfamily, member 14) is a protein-coding gene. Diseases associated with TNFRSF14 include herpes simplex, and alcoholic hepatitis, and among its related super-pathways are TNF Signaling and STAT3 Pathway. GO annotations related to this gene include tumor necrosis factor-activated receptor activity and ubiquitin protein ligase binding. An important paralog of this gene is TNFRSF21.

UniProtKB/Swiss-Prot: TNR14_HUMAN, Q92956
Function: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in
lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several
wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells

Gene Wiki entry for TNFRSF14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004350.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF14 gene promoter:
         RP58   Tal-1   Nkx2-5   Nkx5-1   E47   GATA-1   AREB6   E2F   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFRSF14 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.32   Ensembl cytogenetic band:  1p36.32   HGNC cytogenetic band: 1p36.32

TNFRSF14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF14 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P002487:  view genomic region     (about GC identifiers)

Start:
2,487,078 bp from pter      End:
2,496,821 bp from pter
Size:
9,744 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNR14_HUMAN, Q92956 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 14 precursor  
Size: 283 amino acids; 30392 Da
Subunit: Interacts with TRAF2, TRAF3 and TRAF5. Interacts with herpes simplex virus 1 (HHV-1) and herpes simplex
virus 1 (HHV-2) envelope glycoprotein D; functions as an entry receptor for these viruses
Subcellular location: Membrane; Single-pass type I membrane protein (Probable)
3 PDB 3D structures from and Proteopedia for TNFRSF14:
1JMA (3D)        2AW2 (3D)        4FHQ (3D)    
Secondary accessions: B9DI89 Q6IB95 Q8WXR1 Q96J31 Q9UM65

Explore the universe of human proteins at neXtProt for TNFRSF14: NX_Q92956

Explore proteomics data for TNFRSF14 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View neXtProt modification sites for NX_Q92956

  • TNFRSF14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNFRSF14 Protein Expression
    REFSEQ proteins: NP_003811.2  
    ENSEMBL proteins: 
     ENSP00000411854   ENSP00000415254   ENSP00000399292   ENSP00000399533   ENSP00000386859  
     ENSP00000347948  
    Reactome Protein details: Q92956
    Human Recombinant Protein Products for TNFRSF14: 
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    Cloud-Clone Corp. Proteins for TNFRSF14 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IC9153189
    GO:0009897external side of plasma membrane IEA--

    TNFRSF14 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: herpes virus entry mediator 
    Tumour necrosis factor (TNF) receptor family

    2 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR022332 TNFR_14

    Graphical View of Domain Structure for InterPro Entry Q92956

    ProtoNet protein and cluster: Q92956

    2 Blocks protein domains:
    IPB001368 TNFR/CD27/30/40/95 cysteine-rich region
    IPB008063 FAS/CD95 receptor family signature


    UniProtKB/Swiss-Prot: TNR14_HUMAN, Q92956
    Similarity: Contains 3 TNFR-Cys repeats


    TNFRSF14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR14_HUMAN, Q92956
    Function: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in
    lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several
    wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells

         Genatlas biochemistry entry for TNFRSF14:
    tumor necrosis factor receptor superfamily,member 14,widely expressed,involved in lymphocyte activation,homolog
    with 4-1BB (CD137)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0005031tumor necrosis factor-activated receptor activity TAS9153189
    GO:0005515protein binding IPI10318773
    GO:0031625ubiquitin protein ligase binding IPI11279055
         
    TNFRSF14 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TNFRSF14:
     Decreased cell number, increas 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tnfrsf14):
     cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging 

    TNFRSF14 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TNFRSF14: Tnfrsf14tm1Csj Tnfrsf14tm1Kpf

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNFRSF14 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNFRSF14 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4Immune System
    Immune System0.56
    Adaptive Immune System0.56
    5PAK Pathway
    Antioxidant Action of Vitamin-C0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFRSF14
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF14 (see all 7)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling

    3 Sino Biological Pathways for TNFRSF14 
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    3        Reactome Pathways for TNFRSF14
        Costimulation by the CD28 family
    Adaptive Immune System
    Immune System


    2         Kegg Pathways  (Kegg details for TNFRSF14):
        Cytokine-cytokine receptor interaction
    Herpes simplex infection


    TNFRSF14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/108 Interacting proteins for TNFRSF14 (Q929561, 2, 3 ENSP000003479484) via UniProtKB, MINT, STRING, and/or I2D (see all 108)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFSF14O435571, 3, ENSP000002459124EBI-1056653,EBI-524131 I2D: score=4 STRING: ENSP00000245912
    TRAF5O004631, 3, ENSP000002614644EBI-1056653,EBI-523498 I2D: score=4 STRING: ENSP00000261464
    IMPA2O147322, 3, ENSP000002691594MINT-8274500 I2D: score=2 STRING: ENSP00000269159
    NDUFS2O753062, 3, ENSP000003569724MINT-8274544 I2D: score=2 STRING: ENSP00000356972
    A2MP010232, 3MINT-8274456 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS9162022
    GO:0007166cell surface receptor signaling pathway TAS9153189
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0031295T cell costimulation TAS--
    GO:0033209tumor necrosis factor-mediated signaling pathway TAS9153189

    TNFRSF14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFRSF14 (TNR14)

    3 IUPHAR Ligands for TNFRSF14 (herpes virus entry mediator)    About this table 
    LigandTypeActionAffinityPubmed IDs
    B and T lymphocyte attenuator
    NoneNone--
    lymphotoxin-α
    NoneNone--
    LIGHT
    NoneNone--

    Search CenterWatch for drugs/clinical trials and news about TNFRSF14 / TNR14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNFRSF14 gene: 
    NM_003820.2  

    Unigene Cluster for TNFRSF14:

    Tumor necrosis factor receptor superfamily, member 14
    Hs.512898  [show with all ESTs]
    Unigene Representative Sequence: AB208808
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426449 ENST00000434817 ENST00000435221 ENST00000451778 ENST00000409119
    ENST00000355716(uc001ajr.3) ENST00000475523 ENST00000442392(uc010nzc.1)
    ENST00000482074 ENST00000496064(uc009vlf.1) ENST00000463471(uc001ajt.1)
    ENST00000466750 ENST00000471768 ENST00000463835 ENST00000482602 ENST00000480305

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB208808.1 AF153978.1 AF373877.1 AF373878.1 AK124010.1 AK130172.1 AK300515.1 AK303468.1 
    AK310076.1 AY358879.1 BC002794.2 BC018882.2 BC029848.1 CR456909.1 U70321.1 U81232.1 

    17 DOTS entries:

    DT.447822  DT.75164844  DT.100750189  DT.95160381  DT.100873025  DT.95160367  DT.95318517  DT.95160377 
    DT.95160386  DT.95210574  DT.97797648  DT.100758999  DT.100841233  DT.121411968  DT.95160385  DT.100743544 
    DT.91709377 

    24/292 AceView cDNA sequences (see all 292):

    AI272861 BM784241 AA844171 AA953959 BM706892 BU734429 AI285507 BM919406 
    CA449318 AA418865 BU617532 BX436515 AI632302 BM987791 BI761634 BM784391 
    AI569081 BM818990 BQ446850 BM818970 BF725912 AF373877 BM921677 BM852140 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF14 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11
    SP1:        -     -     -           -                 -     -     -           -           -                                 
    SP2:                    -           -                 -     -     -           -           -                                 
    SP3:                                -                 -     -     -           -           -                       -         
    SP4:                                -                 -     -     -           -                                             
    SP5:                                -                 -     -     -           -           -     -     -     -     -         


    ECgene alternative splicing isoforms for TNFRSF14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFRSF14 expression in normal human tissues (normalized intensities)      TNFRSF14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACAGTGTA
    TNFRSF14 Expression
    About this image


    TNFRSF14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Melanocytes (Integumentary System)    fully expand to see all 3 entries
             Human EpiDermal Melanocytes-medium (HEM-m)   
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Human EpiDermal Melanocytes-medium (HEM-m)   
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Uncategorized (Uncategorized)
             PureStem progenitor RP1-MV2-6

     -- (Integumentary System)
             SKIN   

    See TNFRSF14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFRSF14

    SOURCE GeneReport for Unigene cluster: Hs.512898

    UniProtKB/Swiss-Prot: TNR14_HUMAN, Q92956
    Tissue specificity: Widely expressed, with the highest expression in lung, spleen and thymus

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF14: 
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              Necrosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF14 gene from 3/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf141 , 5 tumor necrosis factor receptor superfamily, member more1, 5 61.52(n)1
    47.15(a)1
      4 (85.81 cM)5
    2309791  NM_178931.21  NP_849262.11 
     1549222105 
    lizard
    (Anolis carolinensis)
    Reptilia TNFRSF146
    tumor necrosis factor receptor superfamily, member...
    24(a)
    1 ↔ 1
    GL343880.1(124499-139067)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7958581 tumor necrosis factor receptor superfamily member 14-like 47.92(n)
    39.58(a)
      795858  XM_001336090.3  XP_001336126.3 


    ENSEMBL Gene Tree for TNFRSF14 (if available)
    TreeFam Gene Tree for TNFRSF14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFRSF14 gene
    TNFRSF212  TNFRSF11A2  TNFRSF6B2  LTBR2  TNFRSF11B2  CD402  TNFRSF1B2  

    TNFRSF14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/179 SNPs in TNFRSF14 are shown (see all 179)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0130074
    ----see VAR_0130072 K R mis40--------
    rs1870089561,2
    --2486489(+) TGTGAA/GTGCAC 1 -- us2k10--------
    rs115739751,2
    C,F,H--2490452(+) CCATGC/TGGCCA 1 -- int16Minor allele frequency- T:0.02NS EA WA 580
    rs115739761,2
    C,F,H--2490513(+) CCCTGC/GGGCCA 1 -- int16Minor allele frequency- G:0.01NS EA CSA 574
    rs115739771,2
    H--2490658(+) AGGCTG/TGGATT 1 -- int15Minor allele frequency- T:0.00NS EA 572
    rs1853912801,2
    --2490671(+) GGGCTA/CACACC 1 -- int10--------
    rs1415391471,2
    C--2490799(+) CAGCTC/TGTACC 1 -- int10--------
    rs22577631,2
    C,F,A,H--2490898(+) GTTTGA/CGGGGT 1 -- int125Minor allele frequency- C:0.40EA NS NA WA CSA 4163
    rs24776821,2
    --2490899(-) CACCCC/TGCAAA 1 -- int10--------
    rs115739781,2
    C,F,H--2490922(+) GGCACG/TTGGGG 1 -- int15Minor allele frequency- T:0.01NS EA 584

    HapMap Linkage Disequilibrium report for TNFRSF14 (2487078 - 2496821 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for TNFRSF14 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv75n71CNV Loss21882294
    dgv71n71CNV Loss21882294
    nsv870655CNV Loss21882294
    dgv64n71CNV Loss21882294
    nsv824475CNV Loss20364138
    nsv871726CNV Loss21882294
    nsv470684CNV Loss18288195
    dgv79n71CNV Loss21882294
    nsv824364CNV Loss20364138
    esv2471749OTHER Inversion19546169


    Human Gene Mutation Database (HGMD): TNFRSF14
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602746    OMIM disorders: --

    20/24 diseases for TNFRSF14 (see all 24):    About MalaCards
    herpes simplex    alcoholic hepatitis    follicular lymphoma    pertussis
    conjunctivitis    celiac disease    atopy    rheumatoid arthritis
    multiple myeloma    alcoholism    myeloma    arthritis
    type 1 diabetes    systemic lupus erythematosus    multiple sclerosis    lupus erythematosus
    hepatitis    hepatitis b    obesity    retinitis


    TNFRSF14 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for TNFRSF14 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 74.4 18 11119586 (2), 9657005 (1), 19915044 (1), 11511354 (1) (see all 12)
    herpes 51.6 2 19426226 (1), 11164894 (1)
    necrosis 45.2 13 11742877 (1), 9153189 (1), 11976496 (1), 12466117 (1) (see all 11)
    tumors 25.4 16 11742877 (1), 9153189 (1), 11976496 (1), 12466117 (1) (see all 12)
    atherosclerotic plaque 22.4 1 15667572 (1)
    rheumatoid arthritis 0 1 17393389 (1)

    Genetic Association Database (GAD): TNFRSF14
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF14 (20 documents)

    Export disorders for TNFRSF14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFRSF14 gene, integrated from 9 sources (see all 118):
    (articles sorted by number of sources associating them with TNFRSF14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation. (PubMed id 9162061)1, 2, 3, 9 Kwon B.S.... Young P.R. (1997)
    2. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. (PubMed id 8898196)1, 2, 3 Montgomery R.I.... Spear P.G. (1996)
    3. ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. (PubMed id 9153189)1, 2, 9 Hsu H.... Boyle W.J. (1997)
    4. Search for polymorphisms in the genes for herpesvirus entry mediator, Nectin-1, and Nectin-2 in immune seronegative individuals. (PubMed id 11756979)1, 2, 9 Struyf F....Spear P.G. (2002)
    5. Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (2011)
    6. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    7. Acquired TNFRSF14 mutations in follicular lymphoma ar e associated with worse prognosis. (PubMed id 20884631)1, 4 Cheung K.J....Horsman D.E. (2010)
    8. Evidence of epistasis between TNFRSF14 and TNFRSF6B p olymorphisms in patients with rheumatoid arthritis. (PubMed id 20187130)1, 4 Perdigones N....Urcelay E. (2010)
    9. Genetic variants in the prediction of rheumatoid arth ritis. (PubMed id 20439292)1, 4 van der Helm-van Mil A.H....Huizinga T.W. (2010)
    10. PD1 as a common candidate susceptibility gene of suba cute sclerosing panencephalitis. (PubMed id 20066438)1, 4 Ishizaki Y....Hara T. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8764 HGNC: 11912 AceView: TNFRSF14 Ensembl:ENSG00000157873 euGenes: HUgn8764
    ECgene: TNFRSF14 Kegg: 8764 H-InvDB: TNFRSF14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFRSF14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF14 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf14/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNFRSF14 gene:
    Search GeneIP for patents involving TNFRSF14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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