TNFRSF13C Gene
protein-coding GIFtS: 60
GCID: GC22M042321
|
|
tumor necrosis factor receptor superfamily, member 13C
| |
Aliases
for TNFRSF13C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tumor Necrosis Factor Receptor Superfamily, Member 13C1 2 | | CVID42 5 | | BAFFR1 2 3 5 | | BROMIX2 | | CD2681 2 | | B Cell-Activating Factor Receptor2 | | BAFF-R2 3 | | Prolixin1 | | B-Cell-Activating Factor Receptor2 3 | | Tumor Necrosis Factor Receptor Superfamily Member 13C2 | | BAFF Receptor2 3 | | BR33 | | BLyS Receptor 32 3 | | CD268 Antigen3 |
Export aliases for TNFRSF13C gene to outside databasesPrevious GC identifers: GC22M038935 GC22M040564 GC22M040645 GC22M025286 |
Summaries
for TNFRSF13C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TNFRSF13C:
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cellpopulation. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupuserythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposedthat abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing thesurvival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type IIItransmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is theprincipal receptor required for BAFF-mediated mature B-cell survival. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TR13C_HUMAN, Q96RJ3Function: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cellresponse
Gene Wiki entry for TNFRSF13C
|
Genomic Views
for TNFRSF13C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TNFRSF13C gene promoter:
USF1 p53 Sp1 AP-1 USF-1 ATF-2 SEF-1 (1) c-Jun E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for TNFRSF13C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF13C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.1-q13.31 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.1-q13.3TNFRSF13C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M042321: view genomic region
(about GC identifiers)
Start:
|
42,321,036 bp from pter |
End:
|
42,322,822 bp from pter |
Size:
|
1,787 bases |
Orientation:
|
minus strand |
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Proteins
for TNFRSF13C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TR13C_HUMAN, Q96RJ3 (See
protein sequence)Recommended Name: Tumor necrosis factor receptor superfamily member 13C Size: 184 amino acids; 18864 Da
Subcellular location: Membrane; Single-pass type III membrane protein (Probable)
5 PDB 3D structures from  and Proteopedia  for TNFRSF13C:1MPV (3D)
1OQE (3D)
1OSX (3D)
1P0T (3D)
2HFG (3D)
Alternative splicing: 2 isoforms: Q96RJ3-1 Q96RJ3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TNFRSF13C: NX_Q96RJ3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96RJ3
TNFRSF13C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_443177.1
ENSEMBL proteins: ENSP00000291232
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009897 | external side of plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TNFRSF13C for ontologies About GeneDecksing
TNFRSF13C Antibody Products:
Assay Products for TNFRSF13C: |
Protein
Domains /
Families
for TNFRSF13C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TNFRSF13C for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96RJ3ProtoNet protein and cluster: Q96RJ3 1 Blocks protein family: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region
UniProtKB/Swiss-Prot: TR13C_HUMAN, Q96RJ3Similarity: Contains 1 TNFR-Cys repeat |
Function
for TNFRSF13C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TR13C_HUMAN, Q96RJ3Function: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cellresponse
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF13C (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF13C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TNFRSF13C (NM_052945) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNFRSF13C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF13C |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- |
TNFRSF13C for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for TNFRSF13C: Tnfrsf13ctm1Msc Tnfrsf13ctm1Mass
4 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Tnfrsf13c):
TNFRSF13C for phenotypes About GeneDecksing
|
Pathways & Interactions
for TNFRSF13C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | PEDF Induced Signaling | | | 2 | TGF-Beta Pathway | | | 3 | Akt Signaling | | | 4 | BAFF in B-Cell Signaling | | | 5 | TRAF Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TNFRSF13C
1  R&D Systems Pathway for TNFRSF13C
5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF13C (see all 14)
1  GeneGo (Thomson Reuters) Pathway for TNFRSF13C
3 
Kegg Pathways (Kegg details for TNFRSF13C):
TNFRSF13C for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF13C
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/6 Interacting proteins for TNFRSF13C (Q96RJ33 ENSP000002912324) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001782 | B cell homeostasis |
IEA | -- | | GO:0002636 | positive regulation of germinal center formation |
IEA | -- | | GO:0030890 | positive regulation of B cell proliferation |
IEA | -- | | GO:0031295 | T cell costimulation |
IEA | -- | | GO:0031296 | B cell costimulation |
IEA | -- |
TNFRSF13C for ontologies About GeneDecksing
|
Drugs & Compounds
for TNFRSF13C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TNFRSF13C for compounds About GeneDecksing
 Browse Tocris compounds for TNFRSF13C
3 Novoseek chemical compound relationships for TNFRSF13C gene About this table
Search CenterWatch for drugs/clinical trials and news about TNFRSF13C / TR13C
|
Transcripts
for TNFRSF13C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TNFRSF13C gene: NM_052945.3 Unigene Cluster for TNFRSF13C: Tumor necrosis factor receptor superfamily, member 13C Hs.344088 [show with all ESTs]Unigene Representative Sequence: NM_0529451 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000291232(uc003bbl.2 uc010gyp.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF13C (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF13C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TNFRSF13C (NM_052945) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNFRSF13C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF13C |
Additional cDNA sequence: AF373846.1 BC105123.1 BC112030.1 1 DOTS entry: DT.75157341 6 AceView cDNA sequences: AW236483 NM_052945 AX772914 AI250289 AF373846 AX800072
GeneLoc Exon Structure
|
Expression
for TNFRSF13C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TNFRSF13C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTTTGGTG
About this image
See TNFRSF13C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFRSF13C
SOURCE GeneReport for Unigene cluster: Hs.344088
UniProtKB/Swiss-Prot: TR13C_HUMAN, Q96RJ3Tissue specificity: Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels inactivated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes
SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF13C:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFRSF13C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNFRSF13C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF13C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF13C |
Orthologs
for TNFRSF13C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TNFRSF13C gene from 2/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tnfrsf13c1 , 5 |
tumor necrosis factor receptor superfamily, member more1, 5 |
69.9(n)1
61.21(a)1 |
|
15 (38.56 cM)5
720491 NM_028075.21 NP_082351.11
822217445 |
chicken
(Gallus gallus) |
Aves |
TNFRSF13C6 |
tumor necrosis factor receptor superfamily, member... |
28(a) |
1 ↔ 1 |
1(51363876-51365483) |
ENSEMBL Gene Tree for TNFRSF13C (if available)
TreeFam Gene Tree for TNFRSF13C (if available) |
Paralogs
for TNFRSF13C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TNFRSF13C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TNFRSF13C (42321036 - 42322822 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TNFRSF13C: --
Human Gene Mutation Database (HGMD): TNFRSF13C
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFRSF13C |
|
Disorders
/ Diseases
for TNFRSF13C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TNFRSF13C for disorders About GeneDecksing
OMIM gene information: 606269
OMIM disorders: 613494
UniProtKB/Swiss-Prot: TR13C_HUMAN, Q96RJ3
Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; alsocalled antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibodydeficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response toantigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; thenumbers of circulating B-cells is usually in the normal range, but can be low
20/41  diseases for TNFRSF13C (see all 41): About MalaCardssystemic lupus erythematosus lupus erythematosus b-cell non-hodgkin lymphoma common variable immunodeficiency
diffuse large b-cell lymphoma non-hodgkin lymphoma central nervous system lymphoma graft versus host disease
b-cell lymphomas waldenstrom macroglobulinemia primary biliary cirrhosis myasthenia gravis
hodgkin's lymphoma macroglobulinemia acute lymphoblastic leukemia rheumatoid arthritis
b cell deficiency chronic lymphocytic leukemia multiple sclerosis lymphoblastic leukemia
1 disease from the University of Copenhagen DISEASES database for TNFRSF13C:Common variable immunodeficiency 10/15 Novoseek disease relationships for TNFRSF13C gene (see all 15) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| antibody deficiency syndrome |
81.1 |
1 |
19666484 (1) |
| common variable immunodeficiency |
73.3 |
3 |
16160919 (2), 16264328 (1) |
| autoimmune diseases |
66.6 |
5 |
16226112 (1), 19258594 (1), 17185325 (1), 16187941 (1) (see all 5) |
| necrosis |
61.5 |
18 |
16264328 (2), 18064389 (1), 18775026 (1), 15908449 (1) (see all 14) |
| lupus erythematosus systemic |
60.8 |
2 |
17185325 (1), 20097906 (1) |
| lymphoma b-cell |
47.9 |
10 |
19207947 (3) |
| autoimmunity |
47 |
1 |
15585864 (1) |
| lymphoma |
43.7 |
4 |
15642740 (1), 19207947 (1), 11747837 (1) |
| lymphoma follicular |
43.2 |
2 |
19207947 (1) |
| tumors |
40.9 |
14 |
18064389 (1), 18775026 (1), 19291294 (1), 15908449 (1) (see all 12) |
GeneTests: TNFRSF13C
Common Variable Immune Deficiency
Genetic Association Database (GAD): TNFRSF13C
Human Genome Epidemiology (HuGE) Navigator: TNFRSF13C (7 documents)
Export disorders for TNFRSF13C gene to outside databases
|
Publications
for TNFRSF13C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TNFRSF13C gene, integrated from 9 sources (see all 151):
(articles sorted by number of sources associating them with TNFRSF13C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency. (PubMed id 16160919)1, 2, 4, 9 Losi C.G....Plebani A. (2005)
- BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. (PubMed id 11509692)1, 2, 3 Thompson J.S....Ambrose C. (2001)
- BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site. (PubMed id 12755599)1, 2, 9 Gordon N.C....Starovasnik M.A. (2003)
- Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation. (PubMed id 12715002)1, 2, 9 Kim H.M.... Lee J.-O. (2003)
- Ligand-receptor binding revealed by the TNF family member TALL-1. (PubMed id 12721620)1, 2, 9 Liu Y.... Zhang G. (2003)
- B-cell activating factor receptor deficiency is assoc iated with an adult-onset antibody deficiency syndrome in humans. (PubMed id 19666484)1, 2, 9 Warnatz K....Eibel H. (2009)
- Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells. (PubMed id 16840730)1, 2 Lee C.V.... Fuh G. (2006)
- Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. (PubMed id 11591325)1, 2 Yan M.... Dixit V.M. (2001)
- BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders. (PubMed id 16226112)1, 9 Rodig S.J....Dorfman D.M. (2005)
- An atypical tumor necrosis factor (TNF) receptor-associated factor-binding motif of B cell-activating factor belonging to the TNF family (BAFF) receptor mediates induction of the noncanonical NF-kappaB signaling pathway. (PubMed id 15644327)1, 9 Morrison M.D....Sun S.C. (2005)
|
External Searches for TNFRSF13C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TNFRSF13C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TNFRSF13C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TNFRSF13C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TNFRSF13C gene:
Search GeneIP for patents involving TNFRSF13C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TNFRSF13C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TNFRSF13C | | OriGene shRNA RFP for TNFRSF13C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFRSF13C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFRSF13C | | | OriGene Protein Over-expression Lysate for TNFRSF13C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TNFRSF13C | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF13C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF13C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TNFRSF13C | | OriGene Custom Protein Services for TNFRSF13C | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TNFRSF13C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFRSF13C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF13C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFRSF13C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF13C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF13C |
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 | | | TNFRSF13C Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF13C |
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