Aliases for TNFRSF13B Gene
External Ids for TNFRSF13B Gene
Previous GeneCards Identifiers for TNFRSF13B Gene
The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF13B Gene
TNFRSF13B (TNF Receptor Superfamily Member 13B) is a Protein Coding gene. Diseases associated with TNFRSF13B include Immunodeficiency, Common Variable, 2 and Immunoglobulin A Deficiency 2. Among its related pathways are TRAF Pathway and RANK Signaling in Osteoclasts. GO annotations related to this gene include receptor activity.
UniProtKB/Swiss-Prot for TNFRSF13B Gene
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.