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Aliases for TNFRSF13B Gene

Aliases for TNFRSF13B Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 13B 2 3
  • Transmembrane Activator And CAML Interactor 3 4
  • TACI 3 4
  • Tumor Necrosis Factor Receptor 13B 3
  • CD267 Antigen 4
  • TNFRSF14B 3
  • CD267 3
  • CVID2 3
  • IGAD2 3
  • CVID 3
  • RYZN 3

External Ids for TNFRSF13B Gene

Previous GeneCards Identifiers for TNFRSF13B Gene

  • GC17M017204
  • GC17M017953
  • GC17M016785
  • GC17M017042
  • GC17M016783
  • GC17M016595
  • GC17M016832

Summaries for TNFRSF13B Gene

Entrez Gene Summary for TNFRSF13B Gene

  • The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF13B Gene

TNFRSF13B (Tumor Necrosis Factor Receptor Superfamily, Member 13B) is a Protein Coding gene. Diseases associated with TNFRSF13B include tnfrsf13b-related common variable immune deficiency and immunoglobulin a deficiency 2. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for TNFRSF13B Gene

  • Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.

Gene Wiki entry for TNFRSF13B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF13B Gene

Genomics for TNFRSF13B Gene

Regulatory Elements for TNFRSF13B Gene

Genomic Location for TNFRSF13B Gene

Chromosome:
17
Start:
16,929,816 bp from pter
End:
16,972,118 bp from pter
Size:
42,303 bases
Orientation:
Minus strand

Genomic View for TNFRSF13B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF13B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF13B Gene

Proteins for TNFRSF13B Gene

  • Protein details for TNFRSF13B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14836-TR13B_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 13B
    Protein Accession:
    O14836
    Secondary Accessions:
    • B2R8B0
    • B7Z6V8
    • Q32LX4
    • Q7Z6F5

    Protein attributes for TNFRSF13B Gene

    Size:
    293 amino acids
    Molecular mass:
    31816 Da
    Quaternary structure:
    • Binds TRAF2, TRAF5 and TRAF6. Binds the NH2-terminal domain of CAMLG with its C-terminus.

    Three dimensional structures from OCA and Proteopedia for TNFRSF13B Gene

    Alternative splice isoforms for TNFRSF13B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFRSF13B Gene

Proteomics data for TNFRSF13B Gene at MOPED

Post-translational modifications for TNFRSF13B Gene

  • Glycosylation at Asn 128
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF13B Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF13B (TACI/TNFRSF13B)

No data available for DME Specific Peptides for TNFRSF13B Gene

Domains & Families for TNFRSF13B Gene

Gene Families for TNFRSF13B Gene

Protein Domains for TNFRSF13B Gene

Suggested Antigen Peptide Sequences for TNFRSF13B Gene

Graphical View of Domain Structure for InterPro Entry

O14836

UniProtKB/Swiss-Prot:

TR13B_HUMAN :
  • Contains 2 TNFR-Cys repeats.
Similarity:
  • Contains 2 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF13B: view

Function for TNFRSF13B Gene

Molecular function for TNFRSF13B Gene

UniProtKB/Swiss-Prot Function:
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.

Gene Ontology (GO) - Molecular Function for TNFRSF13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9311921
GO:0005515 protein binding IPI 10801128
genes like me logo Genes that share ontologies with TNFRSF13B: view
genes like me logo Genes that share phenotypes with TNFRSF13B: view

Animal Models for TNFRSF13B Gene

MGI Knock Outs for TNFRSF13B:

Animal Model Products

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate TNFRSF13B
    • Block miRNA regulation of TNFRSF13B using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF13B

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNFRSF13B Gene

    Localization for TNFRSF13B Gene

    Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF13B Gene

    Membrane; Single-pass type III membrane protein.

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for TNFRSF13B Gene COMPARTMENTS Subcellular localization image for TNFRSF13B gene
    Compartment Confidence
    plasma membrane 4
    nucleus 1

    Gene Ontology (GO) - Cellular Components for TNFRSF13B Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0005886 plasma membrane TAS --
    GO:0005887 integral component of plasma membrane IEA --
    GO:0009897 external side of plasma membrane IEA --
    genes like me logo Genes that share ontologies with TNFRSF13B: view

    Pathways & Interactions for TNFRSF13B Gene

    genes like me logo Genes that share pathways with TNFRSF13B: view

    PCR Array Products

    • Pathway & Disease-focused RT² Profiler PCR Arrays
      • T-cell & B-cell Activation in human,mouse,rat
      • TNF Ligands & Receptors in human,mouse,rat

    SIGNOR curated interactions for TNFRSF13B Gene

    Is activated by:

    Gene Ontology (GO) - Biological Process for TNFRSF13B Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0001782 B cell homeostasis IEA --
    GO:0002244 hematopoietic progenitor cell differentiation IEA --
    GO:0002250 adaptive immune response IEA --
    GO:0007166 cell surface receptor signaling pathway TAS 9311921
    GO:0030889 negative regulation of B cell proliferation IEA --
    genes like me logo Genes that share ontologies with TNFRSF13B: view

    Drugs & Compounds for TNFRSF13B Gene

    (3) Drugs for TNFRSF13B Gene - From: DGIdb, IUPHAR, and NovoSeek

    Name Status Disease Links Group Role Mechanism of Action Clinical Trials
    BAFF Pharma 0
    LYMPHORAD Pharma 0
    Calcium Nutra 0

    (2) Additional Compounds for TNFRSF13B Gene - From: NovoSeek

    genes like me logo Genes that share compounds with TNFRSF13B: view

    Transcripts for TNFRSF13B Gene

    mRNA/cDNA for TNFRSF13B Gene

    (1) REFSEQ mRNAs :
    (7) Additional mRNA sequences :
    (12) Selected AceView cDNA sequences:
    (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

    Unigene Clusters for TNFRSF13B Gene

    Tumor necrosis factor receptor superfamily, member 13B:
    Representative Sequences:

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate TNFRSF13B
      • Block miRNA regulation of TNFRSF13B using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF13B

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF13B Gene

      No ASD Table

      Relevant External Links for TNFRSF13B Gene

      GeneLoc Exon Structure for
      TNFRSF13B
      ECgene alternative splicing isoforms for
      TNFRSF13B

      Expression for TNFRSF13B Gene

      mRNA expression in normal human tissues for TNFRSF13B Gene

      mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

      mRNA differential expression in normal tissues according to GTEx for TNFRSF13B Gene

      This gene is overexpressed in Spleen (x6.3).

      Protein differential expression in normal tissues from HIPED for TNFRSF13B Gene

      This gene is overexpressed in Peripheral blood mononuclear cells (47.6) and Heart (21.1).

      Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF13B Gene



      SOURCE GeneReport for Unigene cluster for TNFRSF13B Gene Hs.158341

      mRNA Expression by UniProt/SwissProt for TNFRSF13B Gene

      O14836-TR13B_HUMAN
      Tissue specificity: Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B-cells and activated T-cells, but not in resting T-cells
      genes like me logo Genes that share expression patterns with TNFRSF13B: view

      Protein tissue co-expression partners for TNFRSF13B Gene

      - Elite partner

      Primer Products

      In Situ Assay Products

      Orthologs for TNFRSF13B Gene

      This gene was present in the common ancestor of chordates.

      Orthologs for TNFRSF13B Gene

      Organism Taxonomy Gene Similarity Type Details
      dog
      (Canis familiaris)
      Mammalia TNFRSF13B 35
      • 77.25 (n)
      • 69.28 (a)
      TNFRSF13B 36
      • 65 (a)
      OneToOne
      mouse
      (Mus musculus)
      Mammalia Tnfrsf13b 35
      • 68.64 (n)
      • 56.78 (a)
      Tnfrsf13b 16
      Tnfrsf13b 36
      • 51 (a)
      OneToOne
      chimpanzee
      (Pan troglodytes)
      Mammalia TNFRSF13B 35
      • 99.54 (n)
      • 99.66 (a)
      TNFRSF13B 36
      • 99 (a)
      OneToOne
      cow
      (Bos Taurus)
      Mammalia TNFRSF13B 36
      • 56 (a)
      OneToOne
      oppossum
      (Monodelphis domestica)
      Mammalia TNFRSF13B 36
      • 42 (a)
      OneToOne
      platypus
      (Ornithorhynchus anatinus)
      Mammalia TNFRSF13B 36
      • 46 (a)
      OneToOne
      chicken
      (Gallus gallus)
      Aves TNFRSF13B 35
      • 56.09 (n)
      • 43.04 (a)
      TNFRSF13B 36
      • 34 (a)
      OneToOne
      lizard
      (Anolis carolinensis)
      Reptilia TNFRSF13B 36
      • 38 (a)
      OneToOne
      Species with no ortholog for TNFRSF13B:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • rainbow trout (Oncorhynchus mykiss)
      • rat (Rattus norvegicus)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)
      • zebrafish (Danio rerio)

      Evolution for TNFRSF13B Gene

      ENSEMBL:
      Gene Tree for TNFRSF13B (if available)
      TreeFam:
      Gene Tree for TNFRSF13B (if available)

      Paralogs for TNFRSF13B Gene

      (1) SIMAP similar genes for TNFRSF13B Gene using alignment to 3 proteins:

      genes like me logo Genes that share paralogs with TNFRSF13B: view

      No data available for Paralogs for TNFRSF13B Gene

      Variants for TNFRSF13B Gene

      Sequence variations from dbSNP and Humsavar for TNFRSF13B Gene

      SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
      rs1004439 -- 16,938,610(+) ACAAC(A/G)CACAC downstream-variant-500B
      rs2274892 -- 16,948,713(-) CCTGC(A/C/G)TGGTG intron-variant
      rs3818716 -- 16,948,520(-) CTGCC(A/G)TGTGA intron-variant
      rs3892371 -- 16,944,116(-) CCCCA(A/C)CCCAG intron-variant
      rs4239139 -- 16,944,017(+) GCCCT(C/G)CTCTC intron-variant

      Structural Variations from Database of Genomic Variants (DGV) for TNFRSF13B Gene

      Variant ID Type Subtype PubMed ID
      nsv833379 CNV Gain 17160897
      nsv155 OTHER Inversion 15895083
      nsv499114 OTHER Inversion 21111241
      nsv907726 CNV Gain 21882294
      esv275147 CNV Gain+Loss 21479260
      esv2666300 CNV Deletion 23128226
      esv2662060 CNV Deletion 23128226
      nsv524738 CNV Loss 19592680

      Variation tolerance for TNFRSF13B Gene

      Residual Variation Intolerance Score: 91.99% of all genes are more intolerant (likely to be disease-causing)
      Gene Damage Index Score: 5.15; 69.42% of all genes are more intolerant (likely to be disease-causing)

      Relevant External Links for TNFRSF13B Gene

      HapMap Linkage Disequilibrium report
      TNFRSF13B
      Human Gene Mutation Database (HGMD)
      TNFRSF13B

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF13B Gene

      Disorders for TNFRSF13B Gene

      MalaCards: The human disease database

      (12) MalaCards diseases for TNFRSF13B Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

      Disorder Aliases PubMed IDs
      tnfrsf13b-related common variable immune deficiency
      • immunodeficiency, common variable, 2
      immunoglobulin a deficiency 2
      • iga, selective deficiency of, taci related
      immunodeficiency, common variable, 2
      • antibody deficiency due to taci defect
      common variable immunodeficiency
      • acquired agammaglobulinemia
      primary agammaglobulinemia
      • antibody deficiency
      - elite association

      UniProtKB/Swiss-Prot

      TR13B_HUMAN
      • Immunodeficiency, common variable, 2 (CVID2) [MIM:240500]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:16007086}. Note=The disease is caused by mutations affecting the gene represented in this entry.
      • Immunoglobulin A deficiency 2 (IGAD2) [MIM:609529]: Selective deficiency of immunoglobulin A (IGAD) is the most common form of primary immunodeficiency, with an incidence of approximately 1 in 600 individuals in the western world. Individuals with symptomatic IGAD often have deficiency of IgG subclasses or decreased antibody response to carbohydrate antigens such as pneumococcal polysaccharide vaccine. Individuals with IGAD also suffer from recurrent sinopulmonary and gastrointestinal infections and have an increased incidence of autoimmune disorders and of lymphoid and non-lymphoid malignancies. In vitro studies have suggested that some individuals with IGAD have impaired isotype class switching to IgA and others may have a post-switch defect. IGAD and CVID have been known to coexist in families. Some individuals initially present with IGAD1 and then develop CVID. These observations suggest that some cases of IGAD and CVID may have a common etiology. {ECO:0000269 PubMed:16007086}. Note=The disease is caused by mutations affecting the gene represented in this entry.

      Relevant External Links for TNFRSF13B

      Genetic Association Database (GAD)
      TNFRSF13B
      Human Genome Epidemiology (HuGE) Navigator
      TNFRSF13B
      Atlas of Genetics and Cytogenetics in Oncology and Haematology:
      TNFRSF13B
      genes like me logo Genes that share disorders with TNFRSF13B: view

      No data available for Genatlas for TNFRSF13B Gene

      Publications for TNFRSF13B Gene

      1. Phenotypic and clinical heterogeneity associated with monoallelic TNFRSF13B-A181E mutations in common variable immunodeficiency. (PMID: 20156508) Dong X. … Abraham R.S. (Hum. Immunol. 2010) 23 67
      2. Lymphocyte characteristics in children with common variable immunodeficiency. (PMID: 20006554) van de Ven A.A. … van Montfrans J.M. (Clin. Immunol. 2010) 23 67
      3. BLyS and APRIL expression in peripheral blood mononuclear cells of cryptococcal meningitis patients and their clinical significance. (PMID: 19909733) Xia R. … Wen H. (Clin. Biochem. 2010) 23 67
      4. APRIL is overexpressed in cancer: link with tumor progression. (PMID: 19291294) Moreaux J. … Klein B. (BMC Cancer 2009) 23 67
      5. An evolutionary approach to the medical implications of the tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) gene. (PMID: 19494827) Sazzini M. … Luiselli D. (Genes Immun. 2009) 23 67

      Products for TNFRSF13B Gene

      • Pathway & Disease-focused RT² Profiler PCR Arrays
        • T-cell & B-cell Activation in human,mouse,rat
        • TNF Ligands & Receptors in human,mouse,rat
      • QIAGEN qRT-PCR Assays for microRNAs that regulate TNFRSF13B
        • QuantiTect SYBR Green Assays in human,mouse,rat
        • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
        • QuantiFast Probe-based Assays in human,mouse,rat
        • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF13B
        • Block miRNA regulation of TNFRSF13B using miScript Target Protectors

        Sources for TNFRSF13B Gene

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