TNFRSF12A Gene

Aliases
for TNFRSF12A gene

Previous GC identifers: GC16P003103 GC16P003070 GC16P003010 GC16P003043 GC16P003091

Summaries
for TNFRSF12A gene

Genomic Views
for TNFRSF12A gene

RefSeq DNA sequence:

NC_000016.9  NC_018927.1  NT_010393.16  

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF12A promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF12A

TNFRSF12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P003121:  view genomic region     (about GC identifiers)

Proteins
for TNFRSF12A gene

3 PDB 3D structures from and Proteopedia for TNFRSF12A:

2EQP (3D)        2KMZ (3D)        2RPJ (3D)    

Explore the universe of human proteins at neXtProt for TNFRSF12A: NX_Q9NP84

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for TNFRSF12A (TWEAK R/TNFRSF12)
	Enzo Life Sciences proteins for TNFRSF12A
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TNFRSF12A OriGene Custom Protein Services for TNFRSF12A
	GenScript Custom Purified and Recombinant Proteins Services for TNFRSF12A
	Novus Biologicals TNFRSF12A Protein
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for TNFRSF12A
	Uscn Proteins for TNFRSF12A

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for TNFRSF12A (TWEAK R/TNFRSF12)
	Cell Signaling Technology (CST) Antibodies for TNFRSF12A  (TweakR)
	OriGene Antibodies (see all 2): TNFRSF12A OriGene Custom Antibody Services for TNFRSF12A
	GenScript Custom Superior Antibodies Services for TNFRSF12A
	Novus Biologicals TNFRSF12A Antibodies
	Abcam antibodies for TNFRSF12A
	Uscn Antibodies for TNFRSF12A
	ThermoFisher Antibodies for TNFRSF12A

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TNFRSF12A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TNFRSF12A

Protein Domains /
Families
for TNFRSF12A gene

ProtoNet protein and cluster: Q9NP84

Function
for TNFRSF12A gene

miRNA Products:		OriGene 3'-UTR Clone: TNFRSF12A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFRSF12A
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFRSF12A (see all 10):
		hsa-miR-3194-5p hsa-miR-561 hsa-miR-4255 hsa-miR-3943 hsa-miR-105 hsa-miR-629* hsa-miR-19b hsa-miR-1296
		SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF12A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFRSF12A (see all 7) OriGene shRNA RFP: TNFRSF12A OriGene siRNA: TNFRSF12A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFRSF12A

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TNFRSF12A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF12A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF12A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TNFRSF12A (NM_016639)
		Sino Biological Human cDNA Clone for TNFRSF12A
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF12A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF12A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TNFRSF12A
		Search LifeMap BioReagents cell lines for TNFRSF12A

In Situ Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TNFRSF12A

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Tnfrsf12a)

Pathways & Interactions
for TNFRSF12A gene

	Super-pathway	contained gene-specific pathways
1	Akt Signaling	Akt Signaling 1.00 Tec Kinases Signaling 0.55 p38 Signaling 0.60
2	Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 1.00 Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 1.00
3	TWEAK Pathway	TWEAK Pathway 1.00 TWEAK Signaling Pathway 0.31
4	PEDF Induced Signaling	STAT3 Pathway 0.47 Cytokine-cytokine receptor interaction 0.26
5	TRAF Pathway	TNF Superfamily Pathway 0.42 TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions 0.08

1 EMD Millipore Pathway for TNFRSF12A

Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

2 R&D Systems Pathways for TNFRSF12A

	TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
	Apoptosis Signaling Pathways

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF12A

	TWEAK Pathway
	STAT3 Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Tec Kinases Signaling

2 Cell Signaling Technology (CST) Pathways for TNFRSF12A

	Apoptosis and Autophagy
	NF-kappaB Signaling

1 GeneGo (Thomson Reuters) Pathway for TNFRSF12A

Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

1 BioSystems Pathway for TNFRSF12A

TWEAK Signaling Pathway

1         Kegg Pathway  (Kegg details for TNFRSF12A)

Cytokine-cytokine receptor interaction

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

Drugs & Compounds
for TNFRSF12A gene

Transcripts
for TNFRSF12A gene

Expression
for TNFRSF12A gene

TNFRSF12A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTGCGCGT

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BoneStylopod Long Bone			Bone
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Secondary follicles (Primary Cell)			Ovary, Reproductive System

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFRSF12A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNFRSF12A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF12A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF12A

In Situ Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TNFRSF12A

Orthologs
for TNFRSF12A gene

Paralogs
for TNFRSF12A gene

Paralogs for TNFRSF12A gene

TNFRSF12A for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for TNFRSF12A
PGOHUM00000262311

Genomic Variants
for TNFRSF12A gene

10/51 NCBI SNPs in TNFRSF12A are shown (see all 51)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs769542761,2	C,	--	3070573(+)	GAACTG/CGGGGA	1	--	int1		1		WA	118
rs747581641,2	C,F,	--	3070628(+)	TCGCTC/TCCGGC	1	--	int1		1		NA	120
rs32169611,2	C,	--	3070709(-)	CCCCC-/CAACCC	1	--	int1		1		CSA	2
rs784350151,2	C	--	3070709(-)	CCCCCA/CAACCC	1	--	int1		0	--	--	--	--
rs80520021,2	C,F,H,	--	3070788(+)	GTCTAG/CGAAGG	1	--	int1		13		NS EA NA CSA WA	787
rs1859388411,2		--	3070849(+)	ACGAGC/TTGGGG	1	--	int1		0	--	--	--	--
rs22327951,2	H	--	3071002(+)	AGGGGG/AGTTGT	1	--	int1		4		NS EA	416
rs22327961,2	C,F,H	--	3071122(+)	CGCCGG/ATGACT	1	--	int1		8		NS EA NA	746
rs1458692021,2	F	--	3071278(+)	ACTGCG/ACGTCT	2	/T /A	mis1		1		NA	2814
rs22327971,2	C,	--	3071298(+)	CGACCA/GCACAG	2	P	syn1 ese3		0	--	--	--	--

HapMap Linkage Disequilibrium report for TNFRSF12A (3068446 - 3072384 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for TNFRSF12A: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFRSF12A

DNA2.0 Custom Variant and Variant Library Synthesis for TNFRSF12A

Disorders / Diseases
for TNFRSF12A gene

20/32 diseases for TNFRSF12A

10/11 Novoseek disease relationships for TNFRSF12A gene (see all 11)    About this table

Publications
for TNFRSF12A gene

PubMed articles for TNFRSF12A gene, integrated from 9 sources (see all 89): (articles sorted by number of sources associating them with TNFRSF12A)

Utopia: connect your pdf to the dynamic world of online information

1. The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. (PubMed id 10751351)^{1, 2, 3, 9} Feng S.-L.Y.... Winkles J.A. (2000)
2. Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily. (PubMed id 19241374)^{1, 2, 9} He F.... Yokoyama S. (2009)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. (PubMed id 11728344)^{1, 2} Wiley S.R.... Fanslow W.C. (2001)
5. The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration. (PubMed id 10551889)^{1, 3} Meighan-Mantha R.L....Winkles J.A. (1999)
6. Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin. (PubMed id 16809572)^{1, 9} Munoz-Garcia B....Blanco-Colio L.M. (2006)
7. The fibroblast growth factor-inducible 14 receptor is highly expressed in HER2-positive breast tumors and regulates breast cancer cell invasive capacity. (PubMed id 18505918)^{1, 9} Willis A.L....Cunliffe H.E. (2008)
8. Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome. (PubMed id 17018610)^{1, 9} Tran N.L....Berens M.E. (2006)
9. The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression. (PubMed id 15611130)^{1, 9} Tran N.L....Berens M.E. (2005)
10. Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth. (PubMed id 14573547)^{1, 9} Tanabe K....Strittmatter S.M. (2003)

External Searches for TNFRSF12A gene

Genome Databases showing TNFRSF12A gene

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Products
for TNFRSF12A gene