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TNFRSF12A Gene

protein-coding   GIFtS: 64
GCID: GC16P003155

Tumor Necrosis Factor Receptor Superfamily, Member 12A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 12A1 2     Tumor Necrosis Factor Receptor Superfamily Member 12A2
FN142 3 5     tweak-receptor2
Fibroblast Growth Factor-Inducible Immediate-Early Response Protein 142 3     Type I Transmembrane Protein Fn142
FGF-Inducible 142 3     Tweak-receptor3
TWEAKR2 5     TweakR3
CD2662     CD266 Antigen3

External Ids:    HGNC: 181521   Entrez Gene: 513302   Ensembl: ENSG000000063277   OMIM: 6059145   UniProtKB: Q9NP843   
ORGUL members:         

Export aliases for TNFRSF12A gene to outside databases

Previous GC identifers: GC16P003103 GC16P003070 GC16P003010 GC16P003043 GC16P003091 GC16P003121 GC16P003141


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TNFRSF12A Gene:
TNFRSF12A (tumor necrosis factor receptor superfamily, member 12A) is a protein-coding gene. Diseases associated with TNFRSF12A include skeletal muscle regeneration, and psoriatic arthritis.

UniProtKB/Swiss-Prot: TNR12_HUMAN, Q9NP84
Function: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the
proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins

Gene Wiki entry for TNFRSF12A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFRSF12A gene promoter:
         COUP-TF1   AP-1   ATF-2   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF12A promoter sequence
   Search Chromatin IP Primers for TNFRSF12A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF12A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

TNFRSF12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF12A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P003155:  view genomic region     (about GC identifiers)

Start:
3,068,446 bp from pter      End:
3,072,384 bp from pter
Size:
3,939 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TNR12_HUMAN, Q9NP84 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 12A precursor  
Size: 129 amino acids; 13911 Da
Subunit: Associates with TRAF1 and TRAF2, and probably also with TRAF3
3 PDB 3D structures from and Proteopedia for TNFRSF12A:
2EQP (3D)        2KMZ (3D)        2RPJ (3D)    
Secondary accessions: D3DUA6 Q9HCS0
Alternative splicing: 2 isoforms:  Q9NP84-1   Q9NP84-2   

Explore the universe of human proteins at neXtProt for TNFRSF12A: NX_Q9NP84

Explore proteomics data for TNFRSF12A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TNFRSF12A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057723.1  
    ENSEMBL proteins: 
     ENSP00000458898   ENSP00000326737   ENSP00000343894   ENSP00000458305   ENSP00000460610  
     ENSP00000461756  

    TNFRSF12A Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TNFRSF12A
    OriGene Custom MassSpec
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    Novus Biologicals TNFRSF12A Protein
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    Cloud-Clone Corp. Proteins for TNFRSF12A

    TNFRSF12A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TNFRSF12A
    R&D Systems Antibodies for TNFRSF12A (TWEAK R/TNFRSF12)
    Cell Signaling Technology (CST) Antibodies for TNFRSF12A  (TweakR)
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    TNFRSF12A Assay Products:

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    Cloud-Clone Corp. CLIAs for TNFRSF12A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: TWEAK receptor
    Tumour necrosis factor (TNF) receptor family

    1 InterPro protein domain:
     IPR022316 TNFR_12

    Graphical View of Domain Structure for InterPro Entry Q9NP84

    ProtoNet protein and cluster: Q9NP84

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNR12_HUMAN, Q9NP84
    Similarity: Contains 1 TNFR-Cys repeat


    TNFRSF12A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR12_HUMAN, Q9NP84
    Function: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the
    proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins
    Induction: By FGF1 and phorbol ester

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    TNFRSF12A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TNFRSF12A:
     Decreased viability of wild-ty 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tnfrsf12a):
     immune system  liver/biliary system 

    TNFRSF12A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tnfrsf12atm1Biib for TNFRSF12A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFRSF12A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF12A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF12A

    miRNA
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    hsa-mir-484 (MIRT042306), hsa-mir-16-5p (MIRT031460), hsa-mir-124-3p (MIRT022342)

    Block miRNA regulation of human, mouse, rat TNFRSF12A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNFRSF12A (see all 10):
    hsa-miR-3194-5p hsa-miR-561 hsa-miR-4255 hsa-miR-3943 hsa-miR-105 hsa-miR-629* hsa-miR-19b hsa-miR-1296
    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF12A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TNFRSF12A
    Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF12A

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TNFRSF12A (NM_016639)
    Sino Biological Human cDNA Clone for TNFRSF12A
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF12A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNR12_HUMAN, Q9NP84: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytoskeleton1
    cytosol1
    extracellular1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IEA--
    GO:0016021integral component of membrane IEA--

    TNFRSF12A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFRSF12A About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2TWEAK Pathway
    TWEAK Pathway0.87
    TWEAK Signaling Pathway0.31
    3PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5PAK Pathway
    Antioxidant Action of Vitamin-C0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for TNFRSF12A
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF12A (see all 8)
        TWEAK Pathway
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    2 Cell Signaling Technology (CST) Pathways for TNFRSF12A
        Apoptosis and Autophagy
    NF-kappaB Signaling

    1 GeneGo (Thomson Reuters) Pathway for TNFRSF12A
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    1 BioSystems Pathway for TNFRSF12A
        TWEAK Signaling Pathway

    3 Sino Biological Pathways for TNFRSF12A
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1 Kegg Pathway  (Kegg details for TNFRSF12A):
        Cytokine-cytokine receptor interaction


    TNFRSF12A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF12A: 
              Nephrotoxicity in human mouse rat
              TNF Ligands & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFRSF12A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for TNFRSF12A (Q9NP841, 3 ENSP000003267374) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFSF12O435081, 3EBI-2851995,EBI-6932080 I2D: score=1 
    TRAF2Q129331, 3, ENSP000002476684EBI-2851995,EBI-355744 I2D: score=2 STRING: ENSP00000247668
    BIRC2Q134901, 3, ENSP000002277584EBI-2851995,EBI-514538 I2D: score=1 STRING: ENSP00000227758
    TRAF5O004633, ENSP000002614644I2D: score=1 STRING: ENSP00000261464
    TRAF1Q130773, ENSP000003629944I2D: score=2 STRING: ENSP00000362994
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006915apoptotic process IEA--
    GO:0006928cellular component movement TAS10551889
    GO:0006931substrate-dependent cell migration, cell attachment to substrate IEA--
    GO:0007155cell adhesion ----

    TNFRSF12A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFRSF12A (TNR12)

    1 IUPHAR Ligand for TNFRSF12A (TWEAK receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    TWEAK
    NoneNone--

    1 Novoseek inferred chemical compound relationship for TNFRSF12A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 47.9 5 15140220 (2), 16945157 (2), 19344712 (1)



    TNFRSF12A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TNFRSF12A gene: 
    NM_016639.2  

    Unigene Cluster for TNFRSF12A:

    Tumor necrosis factor receptor superfamily, member 12A
    Hs.355899  [show with all ESTs]
    Unigene Representative Sequence: BM555452
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000573001 ENST00000326577(uc002csv.4 uc002csw.4) ENST00000341627
    ENST00000574699 ENST00000575124 ENST00000575836 ENST00000571351
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TNFRSF12A (see all 10):
    hsa-miR-3194-5p hsa-miR-561 hsa-miR-4255 hsa-miR-3943 hsa-miR-105 hsa-miR-629* hsa-miR-19b hsa-miR-1296
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      QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF12A
      QuantiFast Probe-based Assays in human, mouse, rat TNFRSF12A

    Additional mRNA sequence: 

    AB035480.1 AB035481.1 AF191148.1 BC002718.2 

    7 DOTS entries:

    DT.111033  DT.101984871  DT.100760107  DT.97765323  DT.100760111  DT.97860093  DT.100754245 

    Selected AceView cDNA sequences (see all 274):

    BG164974 AI221536 BQ011720 BM772326 AL555619 CF126162 CR589964 BG753581 
    CA454367 BM760289 BM989212 BM772335 BG324740 BM846034 AI827127 BQ086281 
    BM847996 BQ012085 AA970894 AI264959 BU754012 BM849845 BQ217673 BU152858 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF12A    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5
    SP1:        -     -     -     -     -     -                     
    SP2:                                -     -                     
    SP3:                                -                           
    SP4:                                -     -     -               
    SP5:                                      -     -               


    ECgene alternative splicing isoforms for TNFRSF12A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFRSF12A expression in normal human tissues (normalized intensities)      TNFRSF12A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTGCGCGT
    TNFRSF12A Expression
    About this image


    TNFRSF12A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)
             Secondary follicles
     
     Bone (Muscoskeletal System)
             Stylopod Long Bone
     
     Brain (Nervous System)
             Cerebellum
     
     Pancreas (Endocrine System)
     
     Fibroblasts (Uncategorized)
    TNFRSF12A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFRSF12A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.355899

    UniProtKB/Swiss-Prot: TNR12_HUMAN, Q9NP84
    Tissue specificity: Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal
    muscle and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF12A: 
              Nephrotoxicity in human mouse rat
              TNF Ligands & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TNFRSF12A
    OriGene qSTAR qPCR primer pairs in human, mouse for TNFRSF12A
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    QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF12A
    QuantiFast Probe-based Assays in human, mouse, rat TNFRSF12A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF12A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF12A gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf12a1 , 5 tumor necrosis factor receptor superfamily, member more1, 5 85.98(n)1
    88.79(a)1
      17 (11.99 cM)5
    272791  NM_013749.21  NP_038777.21 
     236754475 
    lizard
    (Anolis carolinensis)
    Reptilia TNFRSF12A6
    tumor necrosis factor receptor superfamily, member...
    48(a)
    1 ↔ 1
    GL343606.1(3430-7676)


    ENSEMBL Gene Tree for TNFRSF12A (if available)
    TreeFam Gene Tree for TNFRSF12A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNFRSF12A gene

    TNFRSF12A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TNFRSF12A
    PGOHUM00000262311


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFRSF12A (see all 50)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs769542761,2
    C,F--3070573(+) GAACTG/CGGGGA 1 -- int11Minor allele frequency- C:0.01WA 118
    rs747581641,2
    C,F--3070628(+) TCGCTC/TCCGGC 1 -- int11Minor allele frequency- T:0.06NA 120
    rs32169611,2
    C--3070709(-) CCCCC-/CAACCC 1 -- int11Minor allele frequency- C:0.00CSA 2
    rs784350151,2
    C--3070709(-) CCCCCA/CAACCC 1 -- int10--------
    rs80520021,2
    C,F,H--3070788(+) GTCTAG/CGAAGG 1 -- int113Minor allele frequency- C:0.21NS EA NA CSA WA 787
    rs1859388411,2
    --3070849(+) ACGAGC/TTGGGG 1 -- int10--------
    rs22327951,2
    H--3071002(+) AGGGGG/AGTTGT 1 -- int14Minor allele frequency- A:0.00NS EA 416
    rs22327961,2
    C,F,H--3071122(+) CGCCGG/ATGACT 1 -- int18Minor allele frequency- A:0.01NS EA NA 746
    rs1997938101,2
    C--3071246(+) CTCCTA/GGAGCG 2 * W stg10--------
    rs1458692021,2
    F--3071278(+) ACTGCG/ACGTCT 2 /T /A mis11Minor allele frequency- A:0.00NA 2814

    HapMap Linkage Disequilibrium report for TNFRSF12A (3068446 - 3072384 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TNFRSF12A (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509588CNV Insertion20534489
    dgv2579n71CNV Loss21882294
    nsv510673CNV Loss20534489
    nsv905193CNV Loss21882294
    nsv905170CNV Loss21882294
    nsv905185CNV Loss21882294
    nsv905197CNV Loss21882294
    dgv2575n71CNV Loss21882294
    nsv833125CNV Loss17160897
    dgv2576n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFRSF12A
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFRSF12A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605914    OMIM disorders: --

    Selected diseases for TNFRSF12A (see all 35):    About MalaCards
    skeletal muscle regeneration    psoriatic arthritis    glioblastoma multiforme    lupus nephritis
    alcoholic hepatitis    nephritis    multiple sclerosis    kaposi's sarcoma
    gingivitis    colon adenocarcinoma    atherosclerosis    multiple myeloma
    rheumatoid arthritis    arthritis    hypoxia    myeloma
    inflammatory bowel disease    renal cell carcinoma    hepatitis b    sarcoma


    TNFRSF12A for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TNFRSF12A gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 62.9 26 15611130 (2), 19241374 (2), 17917114 (1), 19349318 (1) (see all 17)
    tumors 46.4 49 18505918 (2), 19513634 (2), 15611130 (2), 12651623 (2) (see all 22)
    glioblastoma multiforme 42.5 2 19861406 (1), 15611130 (1)
    inflammation 36 3 20382683 (2), 16503147 (1)
    glioblastoma 31.7 2 15611130 (1), 12651623 (1)
    multiple sclerosis 29 3 18945822 (1), 19018248 (1)
    glioma 27.5 18 17018610 (4), 15611130 (4), 12651623 (3)
    rheumatoid arthritis 22.1 1 19147618 (1)
    stroke 20 4 18793781 (2), 19241374 (1)
    cancer 19.2 9 15885893 (2), 20189297 (1), 20068083 (1), 19513634 (1) (see all 6)

    Genetic Association Database (GAD): TNFRSF12A
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF12A (5 documents)

    Export disorders for TNFRSF12A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFRSF12A gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with TNFRSF12A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. (PubMed id 10751351)1, 2, 3, 9 Feng S.-L.Y.... Winkles J.A. (Am. J. Pathol. 2000)
    2. Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily. (PubMed id 19241374)1, 2, 9 He F.... Yokoyama S. (Protein Sci. 2009)
    3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    4. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    6. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. (PubMed id 11728344)1, 2 Wiley S.R.... Fanslow W.C. (Immunity 2001)
    9. The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration. (PubMed id 10551889)1, 3 Meighan-Mantha R.L....Winkles J.A. (J. Biol. Chem. 1999)
    10. Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin. (PubMed id 16809572)1, 9 MuA+oz-GarcA-a B....Blanco-Colio L.M. ( a journal of cerebral circulation 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51330 HGNC: 18152 AceView: TNFRSF12A Ensembl:ENSG00000006327 euGenes: HUgn51330
    ECgene: TNFRSF12A Kegg: 51330 H-InvDB: TNFRSF12A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNFRSF12A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF12A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFRSF12A gene:
    Search GeneIP for patents involving TNFRSF12A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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