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Aliases for TNFRSF12A Gene

Aliases for TNFRSF12A Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 12A 2 3
  • TWEAKR 3 4 6
  • FN14 3 4 6
  • Fibroblast Growth Factor-Inducible Immediate-Early Response Protein 14 3 4
  • FGF-Inducible 14 3 4
  • Tweak-Receptor 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 12A 3
  • Type I Transmembrane Protein Fn14 3
  • CD266 Antigen 4
  • CD266 3

External Ids for TNFRSF12A Gene

Previous GeneCards Identifiers for TNFRSF12A Gene

  • GC16P003103
  • GC16P003070
  • GC16P003010
  • GC16P003043
  • GC16P003091
  • GC16P003121
  • GC16P003141
  • GC16P003155

Summaries for TNFRSF12A Gene

GeneCards Summary for TNFRSF12A Gene

TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily, Member 12A) is a Protein Coding gene. Diseases associated with TNFRSF12A include glioblastoma multiforme and glioblastoma. Among its related pathways are Akt Signaling and Akt Signaling.

UniProtKB/Swiss-Prot for TNFRSF12A Gene

  • Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

Gene Wiki entry for TNFRSF12A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF12A Gene

Genomics for TNFRSF12A Gene

Regulatory Elements for TNFRSF12A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNFRSF12A Gene

Start:
3,018,445 bp from pter
End:
3,022,383 bp from pter
Size:
3,939 bases
Orientation:
Plus strand

Genomic View for TNFRSF12A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF12A Gene

Proteins for TNFRSF12A Gene

  • Protein details for TNFRSF12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP84-TNR12_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 12A
    Protein Accession:
    Q9NP84
    Secondary Accessions:
    • D3DUA6
    • Q9HCS0

    Protein attributes for TNFRSF12A Gene

    Size:
    129 amino acids
    Molecular mass:
    13911 Da
    Quaternary structure:
    • Associates with TRAF1 and TRAF2, and probably also with TRAF3

    Three dimensional structures from OCA and Proteopedia for TNFRSF12A Gene

    Alternative splice isoforms for TNFRSF12A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFRSF12A Gene

Proteomics data for TNFRSF12A Gene at MOPED

Post-translational modifications for TNFRSF12A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNFRSF12A Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF12A (TWEAK R/TNFRSF12)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF12A (TweakR)

Protein Products

  • Enzo Life Sciences proteins for TNFRSF12A
  • Novus Biologicals proteins for TNFRSF12A
  • Cloud-Clone Corp. Proteins for TNFRSF12A

No data available for DME Specific Peptides for TNFRSF12A Gene

Domains for TNFRSF12A Gene

Gene Families for TNFRSF12A Gene

HGNC:
  • CD :CD molecules
  • TNFRSF :Tumor necrosis factor receptor superfamily
IUPHAR :

Protein Domains for TNFRSF12A Gene

Suggested Antigen Peptide Sequences for TNFRSF12A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NP84

UniProtKB/Swiss-Prot:

TNR12_HUMAN :
  • Q9NP84
Similarity:
  • Contains 1 TNFR-Cys repeat.
genes like me logo Genes that share domains with TNFRSF12A: view

Function for TNFRSF12A Gene

Molecular function for TNFRSF12A Gene

UniProtKB/Swiss-Prot Function:
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
UniProtKB/Swiss-Prot Induction:
By FGF1 and phorbol ester

Gene Ontology (GO) - Molecular Function for TNFRSF12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11728344
genes like me logo Genes that share ontologies with TNFRSF12A: view

Phenotypes for TNFRSF12A Gene

genes like me logo Genes that share phenotypes with TNFRSF12A: view

Animal Models for TNFRSF12A Gene

MGI Knock Outs for TNFRSF12A:

Animal Model Products

CRISPR Products

miRNA for TNFRSF12A Gene

miRTarBase miRNAs that target TNFRSF12A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF12A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TNFRSF12A Gene

Localization for TNFRSF12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF12A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFRSF12A Gene COMPARTMENTS Subcellular localization image for TNFRSF12A gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
cytosol 1
extracellular 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TNFRSF12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF12A: view

Pathways for TNFRSF12A Gene

genes like me logo Genes that share pathways with TNFRSF12A: view

Pathways by source for TNFRSF12A Gene

3 Sino Biological pathways for TNFRSF12A Gene
2 Cell Signaling Technology pathways for TNFRSF12A Gene
1 BioSystems pathway for TNFRSF12A Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for TNFRSF12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006931 substrate-dependent cell migration, cell attachment to substrate IEA --
GO:0007155 cell adhesion --
GO:0043065 positive regulation of apoptotic process IDA 21525013
GO:0045765 regulation of angiogenesis IEA --
genes like me logo Genes that share ontologies with TNFRSF12A: view

Compounds for TNFRSF12A Gene

(1) IUPHAR Ligand for TNFRSF12A Gene

Ligand Type Action Affinity Pubmed IDs
TWEAK None None

(1) Novoseek inferred chemical compound relationships for TNFRSF12A Gene

Compound -log(P) Hits PubMed IDs
rantes 47.9 5
genes like me logo Genes that share compounds with TNFRSF12A: view

Transcripts for TNFRSF12A Gene

Unigene Clusters for TNFRSF12A Gene

Tumor necrosis factor receptor superfamily, member 12A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF12A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF12A Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5
SP1: - - - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - -

Relevant External Links for TNFRSF12A Gene

GeneLoc Exon Structure for
TNFRSF12A
ECgene alternative splicing isoforms for
TNFRSF12A

Expression for TNFRSF12A Gene

mRNA expression in normal human tissues for TNFRSF12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF12A Gene

This gene is overexpressed in Artery - Aorta (4.3).

Protein differential expression in normal tissues for TNFRSF12A Gene

This gene is overexpressed in Bone (35.8) and Urine (33.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNFRSF12A Gene

SOURCE GeneReport for Unigene cluster for TNFRSF12A Gene Hs.355899

mRNA Expression by UniProt/SwissProt for TNFRSF12A Gene

Q9NP84-TNR12_HUMAN
Tissue specificity: Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas
genes like me logo Genes that share expressions with TNFRSF12A: view

Expression partners for TNFRSF12A Gene

In Situ Assay Products

Orthologs for TNFRSF12A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF12A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TNFRSF12A 35
  • 88.24 (n)
  • 90.2 (a)
TNFRSF12A 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNFRSF12A 35
  • 89.22 (n)
  • 91.18 (a)
TNFRSF12A 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnfrsf12a 35
  • 85.98 (n)
  • 88.79 (a)
Tnfrsf12a 16
Tnfrsf12a 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF12A 35
  • 100 (n)
  • 100 (a)
TNFRSF12A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfrsf12a 35
  • 85.98 (n)
  • 88.79 (a)
oppossum
(Monodelphis domestica)
Mammalia TNFRSF12A 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFRSF12A 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFRSF12A 36
  • 48 (a)
OneToOne
Species with no ortholog for TNFRSF12A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFRSF12A Gene

ENSEMBL:
Gene Tree for TNFRSF12A (if available)
TreeFam:
Gene Tree for TNFRSF12A (if available)

Paralogs for TNFRSF12A Gene

Pseudogenes.org Pseudogenes for TNFRSF12A Gene

genes like me logo Genes that share paralogs with TNFRSF12A: view

No data available for Paralogs for TNFRSF12A Gene

Variants for TNFRSF12A Gene

Sequence variations from dbSNP and Humsavar for TNFRSF12A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs13209 -- 3,021,963(-) GCCTC(A/G/T)GAGGT utr-variant-3-prime
rs2232795 -- 3,021,001(+) AGGGG(A/G)GTTGT intron-variant
rs2232796 -- 3,021,121(+) CGCCG(A/G)TGACT intron-variant
rs2232797 -- 3,021,297(+) CGACC(A/G)CACAG synonymous-codon, reference
rs2232798 -- 3,021,419(+) AATCA(A/T)TCGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF12A Gene

Variant ID Type Subtype PubMed ID
nsv905162 CNV Gain 21882294
nsv905170 CNV Loss 21882294
dgv2575n71 CNV Loss 21882294
dgv2576n71 CNV Loss 21882294
nsv509588 CNV Insertion 20534489
nsv510673 CNV Loss 20534489
nsv905185 CNV Loss 21882294
dgv2577n71 CNV Loss 21882294
dgv2578n71 CNV Loss 21882294
nsv905193 CNV Loss 21882294
dgv2579n71 CNV Loss 21882294
nsv905197 CNV Loss 21882294
nsv833125 CNV Loss 17160897

Relevant External Links for TNFRSF12A Gene

HapMap Linkage Disequilibrium report
TNFRSF12A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF12A Gene

Disorders for TNFRSF12A Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TNFRSF12A Gene in MalaCards »

(2) Diseases for TNFRSF12A Gene including...

(11) Novoseek inferred disease relationships for TNFRSF12A Gene

Disease -log(P) Hits PubMed IDs
necrosis 62.9 19
tumors 46.4 29
glioblastoma multiforme 42.5 2
inflammation 36 3
glioblastoma 31.7 2

Relevant External Links for TNFRSF12A

Genetic Association Database (GAD)
TNFRSF12A
Human Genome Epidemiology (HuGE) Navigator
TNFRSF12A
genes like me logo Genes that share disorders with TNFRSF12A: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for TNFRSF12A Gene

Publications for TNFRSF12A Gene

  1. The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. (PMID: 10751351) Feng S.-L.Y. … Winkles J.A. (Am. J. Pathol. 2000) 2 3 4 23
  2. Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily. (PMID: 19241374) He F. … Yokoyama S. (Protein Sci. 2009) 3 4 23
  3. Expression of TWEAK and its receptor Fn14 in the multiple sclerosis brain: implications for inflammatory tissue injury. (PMID: 19018248) Serafini B. … Aloisi F. (J. Neuropathol. Exp. Neurol. 2008) 3 23
  4. A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure. (PMID: 19349318) Jain M. … Burkly L.C. (Circulation 2009) 3 23
  5. Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development. (PMID: 19828625) Alexaki V.I. … Castanas E. (J. Immunol. 2009) 3 23

Products for TNFRSF12A Gene

Sources for TNFRSF12A Gene

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