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Aliases for TNFRSF12A Gene

Aliases for TNFRSF12A Gene

  • TNF Receptor Superfamily Member 12A 2 3 5
  • Fibroblast Growth Factor-Inducible Immediate-Early Response Protein 14 3 4
  • FGF-Inducible 14 3 4
  • Tweak-Receptor 3 4
  • TWEAKR 3 4
  • FN14 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 12A 2
  • Tumor Necrosis Factor Receptor Superfamily Member 12A 3
  • Type I Transmembrane Protein Fn14 3
  • CD266 Antigen 4
  • CD266 3

External Ids for TNFRSF12A Gene

Previous GeneCards Identifiers for TNFRSF12A Gene

  • GC16P003103
  • GC16P003070
  • GC16P003010
  • GC16P003043
  • GC16P003091
  • GC16P003121
  • GC16P003141
  • GC16P003155

Summaries for TNFRSF12A Gene

GeneCards Summary for TNFRSF12A Gene

TNFRSF12A (TNF Receptor Superfamily Member 12A) is a Protein Coding gene. Among its related pathways are TRAF Pathway and Apoptosis and Autophagy.

UniProtKB/Swiss-Prot for TNFRSF12A Gene

  • Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

Gene Wiki entry for TNFRSF12A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF12A Gene

Genomics for TNFRSF12A Gene

Regulatory Elements for TNFRSF12A Gene

Enhancers for TNFRSF12A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G003069 2 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +55.9 55935 9.8 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A YBX1 ZNF2 ZBTB7B ZNF205 LOC105371058 MMP25 IL32 FLYWCH2 BICDL2 LOC100128770 CLDN6 THOC6 HCFC1R1
GH16G003097 2 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +81.7 81656 6.2 CREB3L1 MLX ZFP64 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF205 ZNF263 SNHG19 SNORD60 ZNF213-AS1 THOC6 ZNF597 ERVK13-1 LOC105371055 CREBBP
GH16G003052 1.5 Ensembl ENCODE dbSUPER 12.4 +36.0 35992 3.7 HDGF ATF1 DMAP1 GLIS2 ELK1 ZNF207 ZNF518A ZNF592 ZNF579 ZNF610 MMP25 BICDL2 IL32 CLDN6 TNFRSF12A ZNF205 CLDN9 PKMYT1 GC16P003092
GH16G003095 1.3 Ensembl ENCODE dbSUPER 11 +77.7 77701 1.3 BCOR CTCF MXI1 ZMYM3 RAD21 RELA ZKSCAN1 POLR2A SMC3 NFE2 ZNF213-AS1 RNU1-125P IL32 MMP25 BICDL2 LOC100128770 HCFC1R1 THOC6 CLDN6 TNFRSF12A
GH16G003960 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.8 +942.5 942482 1.8 TBP BMI1 RAD21 YY1 ZNF121 GLIS2 EGR1 ZNF366 ZSCAN5C SCRT2 SRL CREBBP ADCY9 PPL TNFRSF12A CORO7 GC16M003959 LOC102724927
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFRSF12A on UCSC Golden Path with GeneCards custom track

Genomic Location for TNFRSF12A Gene

Chromosome:
16
Start:
3,018,445 bp from pter
End:
3,022,383 bp from pter
Size:
3,939 bases
Orientation:
Plus strand

Genomic View for TNFRSF12A Gene

Genes around TNFRSF12A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF12A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF12A Gene

Proteins for TNFRSF12A Gene

  • Protein details for TNFRSF12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP84-TNR12_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 12A
    Protein Accession:
    Q9NP84
    Secondary Accessions:
    • D3DUA6
    • Q9HCS0

    Protein attributes for TNFRSF12A Gene

    Size:
    129 amino acids
    Molecular mass:
    13911 Da
    Quaternary structure:
    • Associates with TRAF1 and TRAF2, and probably also with TRAF3.

    Three dimensional structures from OCA and Proteopedia for TNFRSF12A Gene

    Alternative splice isoforms for TNFRSF12A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFRSF12A Gene

Post-translational modifications for TNFRSF12A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNFRSF12A Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF12A (TWEAK R/TNFRSF12)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF12A (TweakR)
  • Santa Cruz Biotechnology (SCBT) Antibodies for TNFRSF12A

No data available for DME Specific Peptides for TNFRSF12A Gene

Domains & Families for TNFRSF12A Gene

Protein Domains for TNFRSF12A Gene

Suggested Antigen Peptide Sequences for TNFRSF12A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFRSF12A: view

No data available for UniProtKB/Swiss-Prot for TNFRSF12A Gene

Function for TNFRSF12A Gene

Molecular function for TNFRSF12A Gene

UniProtKB/Swiss-Prot Function:
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
UniProtKB/Swiss-Prot Induction:
By FGF1 and phorbol ester.

Gene Ontology (GO) - Molecular Function for TNFRSF12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11728344
genes like me logo Genes that share ontologies with TNFRSF12A: view
genes like me logo Genes that share phenotypes with TNFRSF12A: view

Animal Models for TNFRSF12A Gene

MGI Knock Outs for TNFRSF12A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for TNFRSF12A (TWEAK R/TNFRSF12)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF12A Gene

Localization for TNFRSF12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF12A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF12A gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
extracellular 2
cytosol 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TNFRSF12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF12A: view

Pathways & Interactions for TNFRSF12A Gene

genes like me logo Genes that share pathways with TNFRSF12A: view

Gene Ontology (GO) - Biological Process for TNFRSF12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006915 apoptotic process IEA --
GO:0006931 substrate-dependent cell migration, cell attachment to substrate IEA --
GO:0007155 cell adhesion IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with TNFRSF12A: view

No data available for SIGNOR curated interactions for TNFRSF12A Gene

Drugs & Compounds for TNFRSF12A Gene

(1) Drugs for TNFRSF12A Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TWEAK Pharma 0

(1) Additional Compounds for TNFRSF12A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF12A: view

Transcripts for TNFRSF12A Gene

Unigene Clusters for TNFRSF12A Gene

Tumor necrosis factor receptor superfamily, member 12A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for TNFRSF12A (TWEAK R/TNFRSF12)

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF12A Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5
SP1: - - - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - -

Relevant External Links for TNFRSF12A Gene

GeneLoc Exon Structure for
TNFRSF12A
ECgene alternative splicing isoforms for
TNFRSF12A

Expression for TNFRSF12A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF12A Gene

This gene is overexpressed in Artery - Aorta (x4.3).

Protein differential expression in normal tissues from HIPED for TNFRSF12A Gene

This gene is overexpressed in Bone (35.8) and Urine (33.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNFRSF12A Gene



Protein tissue co-expression partners for TNFRSF12A Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF12A Gene:

TNFRSF12A

SOURCE GeneReport for Unigene cluster for TNFRSF12A Gene:

Hs.355899

mRNA Expression by UniProt/SwissProt for TNFRSF12A Gene:

Q9NP84-TNR12_HUMAN
Tissue specificity: Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.

Evidence on tissue expression from TISSUES for TNFRSF12A Gene

  • Muscle(2.7)
  • Skin(2.6)
  • Heart(2.5)
  • Kidney(2.4)
  • Liver(2.2)
  • Lung(2.2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with TNFRSF12A: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF12A Gene

Orthologs for TNFRSF12A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF12A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF12A 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia TNFRSF12A 34 35
  • 89.22 (n)
cow
(Bos Taurus)
Mammalia TNFRSF12A 34 35
  • 88.24 (n)
mouse
(Mus musculus)
Mammalia Tnfrsf12a 34 16 35
  • 85.98 (n)
rat
(Rattus norvegicus)
Mammalia Tnfrsf12a 34
  • 85.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TNFRSF12A 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNFRSF12A 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFRSF12A 35
  • 48 (a)
OneToOne
Species where no ortholog for TNFRSF12A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFRSF12A Gene

ENSEMBL:
Gene Tree for TNFRSF12A (if available)
TreeFam:
Gene Tree for TNFRSF12A (if available)

Paralogs for TNFRSF12A Gene

No data available for Paralogs for TNFRSF12A Gene

Variants for TNFRSF12A Gene

Sequence variations from dbSNP and Humsavar for TNFRSF12A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000273802 -- 3,021,354(+) GGACC(C/T)CAGAC intron-variant
rs1000512408 -- 3,019,366(+) CTTTC(-/TTTT)TTTTA upstream-variant-2KB
rs1000950947 -- 3,022,677(+) CCTCC(C/T)TTCCC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1001172979 -- 3,019,173(+) TTACA(A/G)GCGTG upstream-variant-2KB
rs1001933083 -- 3,018,882(+) TGCTG(-/GTT)TTTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF12A Gene

Variant ID Type Subtype PubMed ID
esv3637645 CNV gain 21293372
nsv509588 CNV insertion 20534489
nsv510673 CNV deletion 20534489
nsv833125 CNV loss 17160897
nsv952906 CNV deletion 24416366

Variation tolerance for TNFRSF12A Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF12A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF12A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF12A Gene

Disorders for TNFRSF12A Gene

Relevant External Links for TNFRSF12A

Genetic Association Database (GAD)
TNFRSF12A
Human Genome Epidemiology (HuGE) Navigator
TNFRSF12A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFRSF12A

No disorders were found for TNFRSF12A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFRSF12A Gene

Publications for TNFRSF12A Gene

  1. The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. (PMID: 10751351) Feng S.-L.Y. … Winkles J.A. (Am. J. Pathol. 2000) 2 3 4 22 64
  2. Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily. (PMID: 19241374) He F. … Yokoyama S. (Protein Sci. 2009) 3 4 22 64
  3. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee K.M. … Lan Q. (Am. J. Hematol. 2010) 3 46 64
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 46 64
  5. TWEAK/Fn14 promotes apoptosis of human endometrial cancer cells via caspase pathway. (PMID: 20189297) Wang D. … Chen C. (Cancer Lett. 2010) 3 22 64

Products for TNFRSF12A Gene

Sources for TNFRSF12A Gene

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