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Aliases for TNFRSF12A Gene

Aliases for TNFRSF12A Gene

  • Tumor Necrosis Factor Receptor Superfamily Member 12A 2 3 5
  • Fibroblast Growth Factor-Inducible Immediate-Early Response Protein 14 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 12A 2 3
  • FGF-Inducible 14 3 4
  • Tweak-Receptor 3 4
  • TWEAKR 3 4
  • FN14 3 4
  • Type I Transmembrane Protein Fn14 3
  • CD266 Antigen 4
  • CD266 3

External Ids for TNFRSF12A Gene

Previous GeneCards Identifiers for TNFRSF12A Gene

  • GC16P003103
  • GC16P003070
  • GC16P003010
  • GC16P003043
  • GC16P003091
  • GC16P003121
  • GC16P003141
  • GC16P003155

Summaries for TNFRSF12A Gene

GeneCards Summary for TNFRSF12A Gene

TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily Member 12A) is a Protein Coding gene. Among its related pathways are TWEAK Pathway and TNF Signaling (sino).

UniProtKB/Swiss-Prot for TNFRSF12A Gene

  • Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

Gene Wiki entry for TNFRSF12A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF12A Gene

Genomics for TNFRSF12A Gene

Regulatory Elements for TNFRSF12A Gene

Enhancers for TNFRSF12A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TNFRSF12A on UCSC Golden Path with GeneCards custom track

Promoters for TNFRSF12A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNFRSF12A on UCSC Golden Path with GeneCards custom track

Genomic Location for TNFRSF12A Gene

3,018,445 bp from pter
3,022,383 bp from pter
3,939 bases
Plus strand

Genomic View for TNFRSF12A Gene

Genes around TNFRSF12A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF12A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF12A Gene

Proteins for TNFRSF12A Gene

  • Protein details for TNFRSF12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 12A
    Protein Accession:
    Secondary Accessions:
    • D3DUA6
    • Q9HCS0

    Protein attributes for TNFRSF12A Gene

    129 amino acids
    Molecular mass:
    13911 Da
    Quaternary structure:
    • Associates with TRAF1 and TRAF2, and probably also with TRAF3.

    Three dimensional structures from OCA and Proteopedia for TNFRSF12A Gene

    Alternative splice isoforms for TNFRSF12A Gene


neXtProt entry for TNFRSF12A Gene

Proteomics data for TNFRSF12A Gene at MOPED

Post-translational modifications for TNFRSF12A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNFRSF12A Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF12A (TWEAK R/TNFRSF12)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF12A (TweakR)

No data available for DME Specific Peptides for TNFRSF12A Gene

Domains & Families for TNFRSF12A Gene

Protein Domains for TNFRSF12A Gene

Suggested Antigen Peptide Sequences for TNFRSF12A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 TNFR-Cys repeat.
  • Contains 1 TNFR-Cys repeat.
genes like me logo Genes that share domains with TNFRSF12A: view

Function for TNFRSF12A Gene

Molecular function for TNFRSF12A Gene

UniProtKB/Swiss-Prot Function:
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
UniProtKB/Swiss-Prot Induction:
By FGF1 and phorbol ester.
genes like me logo Genes that share phenotypes with TNFRSF12A: view

Animal Models for TNFRSF12A Gene

MGI Knock Outs for TNFRSF12A:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF12A Gene

Localization for TNFRSF12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF12A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TNFRSF12A Gene COMPARTMENTS Subcellular localization image for TNFRSF12A gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
cytosol 2
extracellular 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for TNFRSF12A Gene

Pathways & Interactions for TNFRSF12A Gene

genes like me logo Genes that share pathways with TNFRSF12A: view

Pathways by source for TNFRSF12A Gene

Gene Ontology (GO) - Biological Process for TNFRSF12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006931 substrate-dependent cell migration, cell attachment to substrate IEA --
GO:0007155 cell adhesion IEA --
GO:0045765 regulation of angiogenesis IEA --
GO:0045773 positive regulation of axon extension IEA --
genes like me logo Genes that share ontologies with TNFRSF12A: view

No data available for SIGNOR curated interactions for TNFRSF12A Gene

Drugs & Compounds for TNFRSF12A Gene

(1) Drugs for TNFRSF12A Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TWEAK Pharma 0

(1) Additional Compounds for TNFRSF12A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF12A: view

Transcripts for TNFRSF12A Gene

Unigene Clusters for TNFRSF12A Gene

Tumor necrosis factor receptor superfamily, member 12A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF12A Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5
SP1: - - - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - -

Relevant External Links for TNFRSF12A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF12A Gene

mRNA expression in normal human tissues for TNFRSF12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF12A Gene

This gene is overexpressed in Artery - Aorta (x4.3).

Protein differential expression in normal tissues from HIPED for TNFRSF12A Gene

This gene is overexpressed in Bone (35.8) and Urine (33.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNFRSF12A Gene

SOURCE GeneReport for Unigene cluster for TNFRSF12A Gene Hs.355899

mRNA Expression by UniProt/SwissProt for TNFRSF12A Gene

Tissue specificity: Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.
genes like me logo Genes that share expression patterns with TNFRSF12A: view

Protein tissue co-expression partners for TNFRSF12A Gene

Primer Products

Orthologs for TNFRSF12A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF12A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNFRSF12A 35
  • 88.24 (n)
  • 90.2 (a)
  • 87 (a)
(Canis familiaris)
Mammalia TNFRSF12A 35
  • 89.22 (n)
  • 91.18 (a)
  • 86 (a)
(Mus musculus)
Mammalia Tnfrsf12a 35
  • 85.98 (n)
  • 88.79 (a)
Tnfrsf12a 16
Tnfrsf12a 36
  • 81 (a)
(Pan troglodytes)
Mammalia TNFRSF12A 35
  • 100 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tnfrsf12a 35
  • 85.98 (n)
  • 88.79 (a)
(Monodelphis domestica)
Mammalia TNFRSF12A 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia TNFRSF12A 36
  • 72 (a)
(Anolis carolinensis)
Reptilia TNFRSF12A 36
  • 48 (a)
Species with no ortholog for TNFRSF12A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFRSF12A Gene

Gene Tree for TNFRSF12A (if available)
Gene Tree for TNFRSF12A (if available)

Paralogs for TNFRSF12A Gene Pseudogenes for TNFRSF12A Gene

genes like me logo Genes that share paralogs with TNFRSF12A: view

No data available for Paralogs for TNFRSF12A Gene

Variants for TNFRSF12A Gene

Sequence variations from dbSNP and Humsavar for TNFRSF12A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs13209 -- 3,021,963(-) GCCTC(A/G/T)GAGGT utr-variant-3-prime
rs78435015 -- 3,020,708(-) CCCCC(A/C)AACCC intron-variant
rs34787333 -- 3,021,988(+) AGGGG(-/G)AACCT utr-variant-3-prime
rs2232795 -- 3,021,001(+) AGGGG(A/G)GTTGT intron-variant
rs2232796 -- 3,021,121(+) CGCCG(A/G)TGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF12A Gene

Variant ID Type Subtype PubMed ID
nsv905162 CNV Gain 21882294
nsv905170 CNV Loss 21882294
dgv2575n71 CNV Loss 21882294
dgv2576n71 CNV Loss 21882294
nsv509588 CNV Insertion 20534489
nsv510673 CNV Loss 20534489
nsv905185 CNV Loss 21882294
dgv2577n71 CNV Loss 21882294
dgv2578n71 CNV Loss 21882294
nsv905193 CNV Loss 21882294
dgv2579n71 CNV Loss 21882294
nsv905197 CNV Loss 21882294
nsv833125 CNV Loss 17160897

Variation tolerance for TNFRSF12A Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TNFRSF12A Gene

Disorders for TNFRSF12A Gene

Relevant External Links for TNFRSF12A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TNFRSF12A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFRSF12A Gene

Publications for TNFRSF12A Gene

  1. The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. (PMID: 10751351) Feng S.-L.Y. … Winkles J.A. (Am. J. Pathol. 2000) 2 3 4 23 67
  2. TWEAK/Fn14 promotes apoptosis of human endometrial cancer cells via caspase pathway. (PMID: 20189297) Wang D. … Chen C. (Cancer Lett. 2010) 3 23
  3. [The expression of TWEAKR/Fn14 in Rheumatoid arthritis fibroblast-like synoviocytes]. (PMID: 20487651) Xia L.P. … Xiao W.G. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010) 3 23
  4. Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily. (PMID: 19241374) He F. … Yokoyama S. (Protein Sci. 2009) 3 23
  5. A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure. (PMID: 19349318) Jain M. … Burkly L.C. (Circulation 2009) 3 23

Products for TNFRSF12A Gene

Sources for TNFRSF12A Gene