Aliases for TNFRSF11B Gene
External Ids for TNFRSF11B Gene
Previous HGNC Symbols for TNFRSF11B Gene
Previous GeneCards Identifiers for TNFRSF11B Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF11B Gene
TNFRSF11B (TNF Receptor Superfamily Member 11b) is a Protein Coding gene. Diseases associated with TNFRSF11B include Paget Disease Of Bone 5, Juvenile-Onset and Paget Disease Of Bone 5, Juvenile. Among its related pathways are TRAF Pathway and Transcription_Role of VDR in regulation of genes involved in osteoporosis. GO annotations related to this gene include receptor activity and cytokine activity. An important paralog of this gene is TNFRSF21.
UniProtKB/Swiss-Prot for TNFRSF11B Gene
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.