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TNFRSF10D Gene

protein-coding   GIFtS: 64
GCID: GC08M022993

Tumor Necrosis Factor Receptor Superfamily, Member 10d,...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy With
Truncated Death Domain1 2
     TRAIL Receptor 42 3
DCR22 3 5     TRAIL Receptor With A Truncated Death Domain2 3
TRAILR42 3 5     CD2642
Decoy Receptor 22 3     TNF Receptor-Related Receptor For TRAIL2
TRAIL-R42 3     Tumor Necrosis Factor Receptor Superfamily Member 10D2
TRUNDD2 3     DcR23
TNF-Related Apoptosis-Inducing Ligand Receptor 42 3     CD264 Antigen3

External Ids:    HGNC: 119071   Entrez Gene: 87932   Ensembl: ENSG000001735307   OMIM: 6036145   UniProtKB: Q9UBN63   

Export aliases for TNFRSF10D gene to outside databases

Previous GC identifers: GC08M022763 GC08M023348 GC08M023016 GC08M023015 GC08M023049 GC08M021537


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFRSF10D Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an
extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This
receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell
apoptosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFRSF10D Gene:
TNFRSF10D (tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain) is a protein-coding gene. Diseases associated with TNFRSF10D include cholecystitis, and primary effusion lymphoma. GO annotations related to this gene include transmembrane signaling receptor activity and TRAIL binding. An important paralog of this gene is TNFRSF10B.

UniProtKB/Swiss-Prot: TR10D_HUMAN, Q9UBN6
Function: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of
inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its
ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226,
it can induce the NF-kappa-B pathway

Gene Wiki entry for TNFRSF10D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFRSF10D gene promoter:
         NF-kappaB1   NF-kappaB   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFRSF10D promoter sequence
   Search Chromatin IP Primers for TNFRSF10D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF10D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21

TNFRSF10D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF10D gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M022993:  view genomic region     (about GC identifiers)

Start:
22,993,101 bp from pter      End:
23,021,543 bp from pter
Size:
28,443 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TR10D_HUMAN, Q9UBN6 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 10D precursor  
Size: 386 amino acids; 41823 Da
Secondary accessions: B2R8W0 Q9Y6Q4

Explore the universe of human proteins at neXtProt for TNFRSF10D: NX_Q9UBN6

Explore proteomics data for TNFRSF10D at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys241
  • Glycosylation2 at Asn127, Asn182
  • Modification sites at PhosphoSitePlus

  • See TNFRSF10D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003831.2  
    ENSEMBL proteins: 
     ENSP00000310263  

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    TNFRSF10D Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: decoy receptor 2
    Tumour necrosis factor (TNF) receptor family

    2 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR020465 TNFR_10

    Graphical View of Domain Structure for InterPro Entry Q9UBN6

    ProtoNet protein and cluster: Q9UBN6

    1 Blocks protein domain: IPB000488 Death domain

    UniProtKB/Swiss-Prot: TR10D_HUMAN, Q9UBN6
    Similarity: Contains 1 death domain
    Similarity: Contains 3 TNFR-Cys repeats


    TNFRSF10D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TR10D_HUMAN, Q9UBN6
    Function: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of
    inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its
    ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226,
    it can induce the NF-kappa-B pathway

         Genatlas biochemistry entry for TNFRSF10D:
    tumor necrosis factor receptor superfamily,member 10C,abundant in fetal liver and adult testis,TNF related,TP53
    inducible,apoptosis induced ligand (TRAIL) receptor 4,,binding APO2L,inducing NFKB and protecting against
    TRAIL-mediated apoptosis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS9430226
    GO:0005515protein binding ----
    GO:0045569TRAIL binding IEA--
         
    TNFRSF10D for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFRSF10D
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF10D
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF10D

    miRNA
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    miRTarBase miRNAs that target TNFRSF10D:
    hsa-mir-30a-3p (MIRT049916), hsa-mir-335-5p (MIRT018250)

    Block miRNA regulation of human, mouse, rat TNFRSF10D using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TNFRSF10D:
    hsa-miR-133a hsa-miR-496 hsa-miR-133b hsa-miR-1279
    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF10D 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF10D

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    Sino Biological Human cDNA Clone for TNFRSF10D
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF10D


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TR10D_HUMAN, Q9UBN6: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TNFRSF10D for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFRSF10D About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    PGC1Alpha Pathway0.51
    Glucocorticoid Receptor Signaling0.43
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    2Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    JAK-STAT Pathway0.57
    4TWEAK Pathway
    Apoptosis through Death Receptors0.42
    TRAIL Pathway0.40
    5Influenza A
    Influenza A0.34
    Measles0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFRSF10D
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF10D (see all 14)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Glucocorticoid Receptor Signaling
    JAK-STAT Pathway

    2 Cell Signaling Technology (CST) Pathways for TNFRSF10D
        Apoptosis and Autophagy
    NF-kappaB Signaling

    3 BioSystems Pathways for TNFRSF10D
        Apoptosis Modulation and Signaling
    TRAIL signaling pathway
    Direct p53 effectors



    5 Kegg Pathways  (Kegg details for TNFRSF10D):
        Cytokine-cytokine receptor interaction
    Apoptosis
    Natural killer cell mediated cytotoxicity
    Measles
    Influenza A


    TNFRSF10D for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF10D: 
              p53 Signaling Pathway in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Prostate Cancer in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFRSF10D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNFRSF10D (Q9UBN63 ENSP000003102634) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096171P266403I2D: score=1 
    ENSG00000224264P266403I2D: score=1 
    ENSG00000226589P266403I2D: score=1 
    ENSG00000231116P266403I2D: score=1 
    VARSP266403I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction TAS9430226
    GO:0043066negative regulation of apoptotic process TAS9430226

    TNFRSF10D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFRSF10D (TR10D)

    8 Novoseek inferred chemical compound relationships for TNFRSF10D gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tri (d) 83.9 9 10690508 (2), 10933923 (1), 11162590 (1)
    doxorubicin 45.4 3 11090076 (1), 12904602 (1), 12496481 (1)
    actinomycin d 27.5 2 12430140 (1)
    5-aza-2'deoxycytidine 23.7 2 14999791 (1)
    cisplatin 21.1 1 12912965 (1)
    etoposide 17.6 3 11090076 (1), 12823542 (1)
    amiloride 11.8 2 15558024 (1), 16059913 (1)
    lipid 5.13 1 16980609 (1)



    TNFRSF10D for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TNFRSF10D gene: 
    NM_003840.4  

    Unigene Cluster for TNFRSF10D:

    Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
    Hs.213467  [show with all ESTs]
    Unigene Representative Sequence: NM_003840
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000312584(uc003xcz.1)
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate TNFRSF10D:
    hsa-miR-133a hsa-miR-496 hsa-miR-133b hsa-miR-1279
    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF10D 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF10D
      QuantiFast Probe-based Assays in human, mouse, rat TNFRSF10D

    Additional mRNA sequence: 

    AF021232.1 AF021233.1 AF023849.1 AF029761.1 AK313528.1 AY358285.1 BC052270.1 

    1 DOTS entry:

    DT.455009 

    Selected AceView cDNA sequences (see all 83):

    AF023849 AF029761 AI308808 CB115763 AA705297 BQ936635 AI738556 AF021233 
    BM791289 BQ936359 AW183161 BM468784 BU541106 BU502588 BM804048 BQ943911 
    AU279940 AW072352 AY358285 AA812408 AI091334 NM_003840 BC052270 AA906020 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFRSF10D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTGTTGG
    TNFRSF10D Expression
    About this image


    TNFRSF10D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Prostate (Endocrine System)
    TNFRSF10D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFRSF10D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.213467

    UniProtKB/Swiss-Prot: TR10D_HUMAN, Q9UBN6
    Tissue specificity: Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and
    liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen,
    pancreas, kidney, lung, placenta and heart

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF10D: 
              p53 Signaling Pathway in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Prostate Cancer in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF10D
    QuantiFast Probe-based Assays in human, mouse, rat TNFRSF10D
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF10D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF10D gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TVB6
    Gallus gallus tumor necrosis factor receptor super...
    20(a)
    1 → many
    22(1270094-1276295)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    17(a)
    1 → many
    GL343679.1(101366-110435)
    zebrafish
    (Danio rerio)
    Actinopterygii hdr6
    tnfrsfa6
    hematopoietic death receptor
    tumor necrosis factor receptor superfamily, member...
    15(a)
    14(a)
    many ↔ many
    many ↔ many
    5(29049495-29059630) ENSDARG00000004392
    21(14375999-14422468) ENSDARG00000004451
            Species with no ortholog for TNFRSF10D

    ENSEMBL Gene Tree for TNFRSF10D (if available)
    TreeFam Gene Tree for TNFRSF10D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNFRSF10D gene
    TNFRSF10B2  TNFRSF10C2  TNFRSF10A2  
    2 SIMAP similar genes for TNFRSF10D using alignment to 1 protein entry:     TR10D_HUMAN:
    TNFRSF10C    TNFRSF10B

    TNFRSF10D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFRSF10D (see all 1332)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357031461,2
    C--22992951(+) AACTCC/-CCCCC 1 -- ds50012Minor allele frequency- -:0.25NA 4
    rs1135987521,2
    C,F--22997528(+) CTGGGT/CACGGT 1 -- int12Minor allele frequency- C:0.04CSA WA 120
    rs593736671,2
    C--22999017(+) AAAAA-/AGTATC 1 -- int10--------
    rs341160061,2
    C--22999783(+) AAAAA-/A/AAA 
            
    GGGAA
    2 -- int1 cds10--------
    rs3695640831,2
    C--23000936(+) CAGGA-/TTTGAG 1 -- int10--------
    rs1122949371,2
    C--23002937(+) ACTGG-/CCCTGC 1 -- int12Minor allele frequency- C:0.25CSA 4
    rs1139564481,2
    C,F--23005366(+) GTCAGG/CAGATC 1 -- int12Minor allele frequency- C:0.50WA CSA 4
    rs1137182191,2
    C--23005668(+) GAATCG/ACTAAA 1 -- int11Minor allele frequency- A:0.00CSA 1
    rs735485131,2
    C,F--23006252(+) TGACAG/AAAATA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs351931661,2
    C--23006414(+) TATCT-/TTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TNFRSF10D (22993101 - 23021543 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TNFRSF10D:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736753CNV Deletion23290073
    esv2736750CNV Deletion23290073
    nsv520728CNV Loss19592680
    dgv68n64CNV Gain17921354
    nsv8326CNV Gain18304495
    nsv818616CNV Gain17921354
    esv28117CNV Gain19812545
    essv19243CNV CNV17122850
    esv8868OTHER Inversion19470904

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603614    OMIM disorders: --

    Selected diseases for TNFRSF10D (see all 52):    
    About MalaCards
    cholecystitis    primary effusion lymphoma    phaeochromocytoma    rhabdoid tumor
    laryngeal squamous cell carcinoma    pancreatic ductal adenocarcinoma    periodontal disease    b-cell chronic lymphocytic leukemia
    measles    periodontitis    osteosarcoma    chronic lymphocytic leukemia
    laryngitis    prostate cancer    oral cancer    colon adenocarcinoma
    malignant glioma    rhabdomyosarcoma    multiple myeloma    pancreatic cancer


    TNFRSF10D for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TNFRSF10D gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 74 22 16093247 (1), 18772312 (1), 11606398 (1), 11698291 (1) (see all 15)
    tumors 60.2 46 11929838 (5), 17570703 (2), 17569106 (2), 10548878 (1) (see all 26)
    cancer 47.6 3 16644104 (1), 18243765 (1)
    prostate cancer 33.8 13 17853923 (4), 11212279 (1), 16541419 (1), 14999791 (1)
    colon carcinoma 33.5 1 11245478 (1)
    ovarian cancer 30.3 3 16093247 (1), 12212122 (1), 14999791 (1)
    glioma 22.9 2 11221847 (1), 9613612 (1)
    osteosarcoma 20.4 1 12398939 (1)
    colon cancer 15.7 6 10933923 (3), 12473583 (1), 11245478 (1)
    metastasis 13.9 1 19147771 (1)

    Genetic Association Database (GAD): TNFRSF10D
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF10D (11 documents)

    Export disorders for TNFRSF10D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFRSF10D gene, integrated from 10 sources (see all 197):
    (articles sorted by number of sources associating them with TNFRSF10D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. (PubMed id 9537512)1, 2, 3, 9 Pan G.... Dixit V.M. (FEBS Lett. 1998)
    2. A novel receptor for Apo2L/TRAIL contains a truncated death domain. (PubMed id 9382840)1, 2, 3, 9 Marsters S.A....Ashkenazi A. (Curr. Biol. 1997)
    3. The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. (PubMed id 9430226)1, 2, 9 Degli-Esposti M.A....Goodwin R.G. (Immunity 1997)
    4. Polymorphisms in TRAIL receptor genes and risk of breast cancer in Spanish women. (PubMed id 17522430)1, 4, 9 Martinez-Ferrandis J.I....Armengod M.E. (Cancer Biomark 2007)
    5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    8. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    9. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    10. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8793 HGNC: 11907 AceView: TNFRSF10D Ensembl:ENSG00000173530 euGenes: HUgn8793
    ECgene: TNFRSF10D Kegg: 8793 H-InvDB: TNFRSF10D

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TNFRSF10D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF10D Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TNFRSF10D gene:
    Search GeneIP for patents involving TNFRSF10D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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