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Aliases for TNFRSF10D Gene

Aliases for TNFRSF10D Gene

  • TNF Receptor Superfamily Member 10d 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy With Truncated Death Domain 2 3
  • TNF-Related Apoptosis-Inducing Ligand Receptor 4 3 4
  • TRAIL Receptor With A Truncated Death Domain 3 4
  • Decoy Receptor 2 3 4
  • TRAIL Receptor 4 3 4
  • TRAIL-R4 3 4
  • TRAILR4 3 4
  • TRUNDD 3 4
  • DCR2 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 10D 3
  • TNF Receptor-Related Receptor For TRAIL 3
  • CD264 Antigen 4
  • CD264 3

External Ids for TNFRSF10D Gene

Previous GeneCards Identifiers for TNFRSF10D Gene

  • GC08M022763
  • GC08M023348
  • GC08M023016
  • GC08M023015
  • GC08M023049
  • GC08M022993
  • GC08M021537

Summaries for TNFRSF10D Gene

Entrez Gene Summary for TNFRSF10D Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF10D Gene

TNFRSF10D (TNF Receptor Superfamily Member 10d) is a Protein Coding gene. Diseases associated with TNFRSF10D include Osteogenic Sarcoma and Prostate Cancer. Among its related pathways are PEDF Induced Signaling and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and TRAIL binding. An important paralog of this gene is TNFRSF10B.

UniProtKB/Swiss-Prot for TNFRSF10D Gene

  • Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.

Gene Wiki entry for TNFRSF10D Gene

Additional gene information for TNFRSF10D Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF10D Gene

Genomics for TNFRSF10D Gene

GeneHancer (GH) Regulatory Elements for TNFRSF10D Gene

Promoters and enhancers for TNFRSF10D Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I023159 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.8 +1.6 1641 5.1 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TNFRSF10D ENSG00000253200 ENTPD4 C8orf58 POLR3D CCAR2 BIN3 CHMP7 LOC389641 TNFRSF10A
GH08I023350 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 2.8 -190.2 -190203 7.3 FOXA2 INSM2 SIN3A BMI1 RAD21 RFX5 ZNF766 ZNF366 RCOR1 FOS LOXL2 ENTPD4 SLC25A37 TNFRSF10D LOC100507156 PIR45078
GH08I023174 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 2.8 -12.5 -12462 3.9 KLF1 FOXA2 JUN ETV1 MAX SIN3A ZIC2 GTF3C2 FOSL1 ZNF335 LOC389641 CHMP7 TNFRSF10A ENSG00000250714 R3HCC1 TNFRSF10C TNFRSF10D TNFRSF10B TNFRSF10A-AS1
GH08I023180 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 1.5 -17.6 -17612 2.9 ELF3 FOXA2 ARID4B RAD21 THRB YY1 ETV6 CREM IKZF2 HMG20B TNFRSF10A LOC389641 ENSG00000250714 CHMP7 R3HCC1 ENTPD4 TNFRSF10D TNFRSF10A-AS1
GH08I023171 Enhancer 0.8 ENCODE 0.4 -7.7 -7729 0.8 HDGF PKNOX1 SMAD1 BMI1 BATF IRF4 TCF12 ZNF207 ZNF143 ATF7 CHMP7 R3HCC1 TNFRSF10D TNFRSF10A-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFRSF10D on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFRSF10D gene promoter:

Genomic Locations for TNFRSF10D Gene

Genomic Locations for TNFRSF10D Gene
chr8:23,135,588-23,164,030
(GRCh38/hg38)
Size:
28,443 bases
Orientation:
Minus strand
chr8:22,993,101-23,021,543
(GRCh37/hg19)

Genomic View for TNFRSF10D Gene

Genes around TNFRSF10D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF10D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF10D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF10D Gene

Proteins for TNFRSF10D Gene

  • Protein details for TNFRSF10D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBN6-TR10D_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 10D
    Protein Accession:
    Q9UBN6
    Secondary Accessions:
    • B2R8W0
    • Q9Y6Q4

    Protein attributes for TNFRSF10D Gene

    Size:
    386 amino acids
    Molecular mass:
    41823 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TNFRSF10D Gene

Post-translational modifications for TNFRSF10D Gene

  • Ubiquitination at posLast=241241
  • Glycosylation at posLast=127127 and isoforms=182

Other Protein References for TNFRSF10D Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFRSF10D (TRAIL R4/TNFRSF10D)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF10D (TRAIL-R4)
  • Abcam antibodies for TNFRSF10D
  • Santa Cruz Biotechnology (SCBT) Antibodies for TNFRSF10D

No data available for DME Specific Peptides for TNFRSF10D Gene

Domains & Families for TNFRSF10D Gene

Gene Families for TNFRSF10D Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Predicted membrane proteins

Protein Domains for TNFRSF10D Gene

Suggested Antigen Peptide Sequences for TNFRSF10D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFRSF10D: view

No data available for UniProtKB/Swiss-Prot for TNFRSF10D Gene

Function for TNFRSF10D Gene

Molecular function for TNFRSF10D Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 10C,abundant in fetal liver and adult testis,TNF related,TP53 inducible,apoptosis induced ligand (TRAIL) receptor 4,,binding APO2L,inducing NFKB and protecting against TRAIL-mediated apoptosis
UniProtKB/Swiss-Prot Function:
Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.

Gene Ontology (GO) - Molecular Function for TNFRSF10D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9430226
GO:0005031 tumor necrosis factor-activated receptor activity IBA --
GO:0045569 TRAIL binding IEA --
genes like me logo Genes that share ontologies with TNFRSF10D: view
genes like me logo Genes that share phenotypes with TNFRSF10D: view

Clone Products

  • R&D Systems cDNA Clones for TNFRSF10D (TRAIL R4/TNFRSF10D)

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFRSF10D Gene

Localization for TNFRSF10D Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF10D Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF10D gene
Compartment Confidence
plasma membrane 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNFRSF10D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF10D: view

Pathways & Interactions for TNFRSF10D Gene

genes like me logo Genes that share pathways with TNFRSF10D: view

SIGNOR curated interactions for TNFRSF10D Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TNFRSF10D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007165 signal transduction TAS 9430226
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with TNFRSF10D: view

Drugs & Compounds for TNFRSF10D Gene

(5) Drugs for TNFRSF10D Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for TNFRSF10D Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF10D: view

Transcripts for TNFRSF10D Gene

mRNA/cDNA for TNFRSF10D Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(83) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFRSF10D Gene

Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for TNFRSF10D (TRAIL R4/TNFRSF10D)

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF10D Gene

No ASD Table

Relevant External Links for TNFRSF10D Gene

GeneLoc Exon Structure for
TNFRSF10D
ECgene alternative splicing isoforms for
TNFRSF10D

Expression for TNFRSF10D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF10D Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNFRSF10D Gene



NURSA nuclear receptor signaling pathways regulating expression of TNFRSF10D Gene:

TNFRSF10D

SOURCE GeneReport for Unigene cluster for TNFRSF10D Gene:

Hs.213467

mRNA Expression by UniProt/SwissProt for TNFRSF10D Gene:

Q9UBN6-TR10D_HUMAN
Tissue specificity: Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.

Evidence on tissue expression from TISSUES for TNFRSF10D Gene

  • Blood(4.3)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with TNFRSF10D: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF10D Gene

Orthologs for TNFRSF10D Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF10D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF10D 33 34
  • 97.93 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 44 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
TNFRSF10D 34
  • 28 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tnfrsf10b 34
  • 25 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 21 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 16 (a)
OneToMany
chicken
(Gallus gallus)
Aves TVB 34
  • 20 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 17 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hdr 34
  • 15 (a)
ManyToMany
tnfrsfa 34
  • 14 (a)
ManyToMany
Species where no ortholog for TNFRSF10D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF10D Gene

ENSEMBL:
Gene Tree for TNFRSF10D (if available)
TreeFam:
Gene Tree for TNFRSF10D (if available)

Paralogs for TNFRSF10D Gene

Paralogs for TNFRSF10D Gene

(2) SIMAP similar genes for TNFRSF10D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNFRSF10D: view

Variants for TNFRSF10D Gene

Sequence variations from dbSNP and Humsavar for TNFRSF10D Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000048329 -- 23,162,638(-) C/T intron_variant
rs1000183157 -- 23,156,564(-) T/C intron_variant
rs1000583145 -- 23,159,124(-) T/C intron_variant
rs1000636931 -- 23,159,437(-) G/A intron_variant
rs1000736290 -- 23,144,154(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF10D Gene

Variant ID Type Subtype PubMed ID
dgv12057n54 CNV loss 21841781
dgv68n64 CNV gain 17921354
esv2736750 CNV deletion 23290073
esv2736753 CNV deletion 23290073
esv2759604 CNV loss 17122850
esv28117 CNV gain 19812545
esv3333000 CNV duplication 20981092
esv3572636 CNV loss 25503493
esv3616626 CNV gain 21293372
esv3616628 CNV loss 21293372
esv3616629 CNV gain 21293372
esv3616630 CNV gain 21293372
esv8868 OTHER inversion 19470904
nsv1017570 CNV gain 25217958
nsv1025279 CNV loss 25217958
nsv1027718 CNV gain 25217958
nsv1068323 OTHER inversion 25765185
nsv520728 CNV loss 19592680
nsv610775 CNV loss 21841781
nsv818616 CNV gain 17921354
nsv8326 CNV gain 18304495

Variation tolerance for TNFRSF10D Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.83; 79.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFRSF10D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF10D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF10D Gene

Disorders for TNFRSF10D Gene

MalaCards: The human disease database

(2) MalaCards diseases for TNFRSF10D Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
osteogenic sarcoma
  • osteosarcoma; osrc
prostate cancer
  • prostate cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFRSF10D

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNFRSF10D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF10D Gene

Publications for TNFRSF10D Gene

  1. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. (PMID: 9537512) Pan G … Dixit VM (FEBS letters 1998) 2 3 4 22 58
  2. A novel receptor for Apo2L/TRAIL contains a truncated death domain. (PMID: 9382840) Marsters SA … Ashkenazi A (Current biology : CB 1997) 2 3 4 22 58
  3. Polymorphisms in TRAIL receptor genes and risk of breast cancer in Spanish women. (PMID: 17522430) Martinez-Ferrandis JI … Armengod ME (Cancer biomarkers : section A of Disease markers 2007) 3 22 44 58
  4. The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. (PMID: 9430226) Degli-Esposti MA … Goodwin RG (Immunity 1997) 3 4 22 58
  5. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee KM … Lan Q (American journal of hematology 2010) 3 44 58

Products for TNFRSF10D Gene

Sources for TNFRSF10D Gene

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