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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF10D Gene

protein-coding   GIFtS: 62
GCID: GC08M022993

tumor necrosis factor receptor superfamily, member 10d,...
 Explore 58 diseases affiliated with
TNFRSF10D via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TNFRSF10D    

Aliases
for TNFRSF10D gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy With Truncated
Death Domain1 2
     TRAIL-R42 3
TRAILR41 2 3 5     TNF-Related Apoptosis-Inducing Ligand Receptor 42 3
TRUNDD1 2 3     TRAIL Receptor 42 3
DCR22 3 5     TRAIL Receptor With A Truncated Death Domain2 3
CD2641 2     TNF Receptor-Related Receptor For TRAIL2
DcR21 3     Tumor Necrosis Factor Receptor Superfamily Member 10D2
Decoy Receptor 22 3     CD264 Antigen3

External Ids:    HGNC: 119071   Entrez Gene: 87932   Ensembl: ENSG000001735307   OMIM: 6036145   UniProtKB: Q9UBN63   

Export aliases for TNFRSF10D gene to outside databases

Previous GC identifers: GC08M022763 GC08M023348 GC08M023016 GC08M023015 GC08M023049 GC08M021537


Summaries
for TNFRSF10D gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TNFRSF10D:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular
TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce
apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: TR10D_HUMAN, Q9UBN6
Function: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of
inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its
ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it
can induce the NF-kappa-B pathway

Gene Wiki entry for TNFRSF10D


Genomic Views
for TNFRSF10D gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF10D gene promoter:
         NF-kappaB1   NF-kappaB   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNFRSF10D promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF10D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF10D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21

TNFRSF10D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF10D gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M022993:  view genomic region     (about GC identifiers)

Start:
 22,993,101 bp from pter      End:
 23,021,543 bp from pter
Size:
 28,443 bases      Orientation:
 minus strand

Proteins
for TNFRSF10D gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TR10D_HUMAN, Q9UBN6 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 10D precursor  
Size: 386 amino acids; 41823 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: B2R8W0 Q9Y6Q4

Explore the universe of human proteins at neXtProt for TNFRSF10D: NX_Q9UBN6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UBN6

    • TNFRSF10D Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003831.2  
    ENSEMBL proteins: 
     ENSP00000310263  

    Human Recombinant Protein Products: 
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    Novus Biologicals TNFRSF10D Proteins
    Novus Biologicals TNFRSF10D Lysate
    Sino Biological Recombinant Protein for TNFRSF10D
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TNFRSF10D

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    TNFRSF10D for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TNFRSF10D gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TNFRSF10D for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR020465 TNFR_10

    Graphical View of Domain Structure for InterPro Entry Q9UBN6

    ProtoNet protein and cluster: Q9UBN6

    1 Blocks protein family: IPB000488 Death domain

    UniProtKB/Swiss-Prot: TR10D_HUMAN, Q9UBN6
    Similarity: Contains 1 death domain
    Similarity: Contains 3 TNFR-Cys repeats


    Function
    for TNFRSF10D gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TR10D_HUMAN, Q9UBN6
    Function: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of
    inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its
    ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it
    can induce the NF-kappa-B pathway

         Genatlas biochemistry entry for TNFRSF10D:
    tumor necrosis factor receptor superfamily,member 10C,abundant in fetal liver and adult testis,TNF related,TP53
    inducible,apoptosis induced ligand (TRAIL) receptor 4,,binding APO2L,inducing NFKB and protecting against
    TRAIL-mediated apoptosis

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF10D 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS9430226
    GO:0045569TRAIL binding IEA--


    TNFRSF10D for ontologies           About GeneDecksing



    Pathways & Interactions
    for TNFRSF10D gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    		STAT3 Pathway0.47
    		Glucocorticoid Receptor Signaling0.27
    		PGC1Alpha Pathway0.33
    		Cytokine-cytokine receptor interaction0.26
    2TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		JAK-STAT Pathway0.57
    3Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    4Measles
    		Measles1.00
    		Influenza A0.35
    5TWEAK Pathway
    		TRAIL Pathway0.40
    		Apoptosis through Death Receptors0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for TNFRSF10D
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF10D (see all 14)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Glucocorticoid Receptor Signaling
    JAK-STAT Pathway

    2 Cell Signaling Technology (CST) Pathways for TNFRSF10D
        Apoptosis and Autophagy
    NF-kappaB Signaling

    3 BioSystems Pathways for TNFRSF10D 
        Apoptosis Modulation and Signaling
    Direct p53 effectors
    TRAIL signaling pathway


    5         Kegg Pathways  (Kegg details for TNFRSF10D):
        Cytokine-cytokine receptor interaction
    Apoptosis
    Natural killer cell mediated cytotoxicity
    Measles
    Influenza A


    TNFRSF10D for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF10D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/53 Interacting proteins for TNFRSF10D (Q9UBN63 ENSP000003102634) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFSF10P505913, ENSP000002412614I2D: score=3 STRING: ENSP00000241261
    MYH10P355803, ENSP000002692434I2D: score=2 STRING: ENSP00000269243
    CALRP277973, ENSP000003208664I2D: score=1 STRING: ENSP00000320866
    DARSP148683, ENSP000002641614I2D: score=1 STRING: ENSP00000264161
    GSPT1P151703, ENSP000003981314I2D: score=1 STRING: ENSP00000398131
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction TAS9430226
    GO:0043066negative regulation of apoptotic process TAS9430226


    TNFRSF10D for ontologies           About GeneDecksing



    Drugs & Compounds
    for TNFRSF10D gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNFRSF10D for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFRSF10D
    8 Novoseek chemical compound relationships for TNFRSF10D gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tri (d) 83.9 9 10690508 (2), 10933923 (1), 11162590 (1)
    doxorubicin 45.4 3 11090076 (1), 12904602 (1), 12496481 (1)
    actinomycin d 27.5 2 12430140 (1)
    5-aza-2'deoxycytidine 23.7 2 14999791 (1)
    cisplatin 21.1 1 12912965 (1)
    etoposide 17.6 3 11090076 (1), 12823542 (1)
    amiloride 11.8 2 15558024 (1), 16059913 (1)
    lipid 5.13 1 16980609 (1)

    Search CenterWatch for drugs/clinical trials and news about TNFRSF10D / TR10D 

    Transcripts
    for TNFRSF10D gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TNFRSF10D gene: 
    NM_003840.4  

    Unigene Cluster for TNFRSF10D:

    Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
    Hs.213467  [show with all ESTs]
    Unigene Representative Sequence: NM_003840
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000312584(uc003xcz.1)

    miRNA
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    hsa-miR-133a hsa-miR-496 hsa-miR-133b hsa-miR-1279
    SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF10D 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF021232.1 AF021233.1 AF023849.1 AF029761.1 AK313528.1 AY358285.1 BC052270.1 

    1 DOTS entry:

    DT.455009 

    24/83 AceView cDNA sequences (see all 83):

    AF023849 AA906020 BM804048 AI094033 BU502588 AA705297 BM468784 AU279940 
    AI091334 NM_003840 AF021233 AW183161 AY358285 AW072352 AF021232 BM791289 
    BU541106 BC052270 AI738556 AI913350 AA812408 AI308808 CB115763 AF029761 

    GeneLoc Exon Structure


    Expression
    for TNFRSF10D gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFRSF10D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATTGTTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TNFRSF10D expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TNFRSF10D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFRSF10D

    SOURCE GeneReport for Unigene cluster: Hs.213467

    UniProtKB/Swiss-Prot: TR10D_HUMAN, Q9UBN6
    Tissue specificity: Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver.
    Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas,
    kidney, lung, placenta and heart

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF10D: 
              p53 Signaling Pathway in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Prostate Cancer in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF10D

    Orthologs
    for TNFRSF10D gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF10D gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RHOBTB26
    LOC3789026
    		 Rho-related BTB domain containing 2
    death domain-containing tumor necrosis factor rece...
    		 19(a)
    17(a)
    		 1 ↔ many
    possible ortholog
    		 22(1282197-1286445)
    5(14153126-14162752)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 14(a)
    		 1 → many
    		 GL343679.1(101366-110435)
    zebrafish
    (Danio rerio)    		 Actinopterygii tnfrsfa6
    hdr6
    		 hematopoietic death receptor
    		 16(a)
    15(a)
    		 many ↔ many
    many ↔ many
    		 21(14375999-14422468)
    5(29049495-29059630)


    ENSEMBL Gene Tree for TNFRSF10D (if available)
    TreeFam Gene Tree for TNFRSF10D (if available) 

    Paralogs
    for TNFRSF10D gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFRSF10D gene
    TNFRSF10B2  TNFRSF10C2  FAS2  TNFRSF10A2  
    2 SIMAP similar genes for TNFRSF10D using alignment to 1 protein entry:     TR10D_HUMAN:
    TNFRSF10C    TNFRSF10B

    TNFRSF10D for paralogs           About GeneDecksing



    Genomic Variants
    for TNFRSF10D gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1110 NCBI SNPs in TNFRSF10D are shown (see all 1110)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1893143461,2
    		--22992659(+) GCAGCC/TGCAGC 1 -- ds50010--------
    rs1160426891,2
    		F,--22992695(+) ACAGCA/GTGGGA 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs759758131,2
    		F,--22992799(+) GGCTGA/GGCAAC 1 -- ds50011Minor allele frequency- G:0.02EA 120
    rs1473291021,2
    		--22992885(+) AGGGAA/GGAGGC 1 -- ds50010--------
    rs1409787021,2
    		--22992891(+) GAGGCA/GCGAAT 1 -- ds50010--------
    rs1808493071,2
    		--22992917(+) CCTGGC/TCCTTT 1 -- ds50010--------
    rs715468521,2
    		C,--22992950(+) AAACTC/-CCCCC 1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs357031461,2
    		C--22992952(+) AACTCC/-CCCCC 1 -- ds50011Minor allele frequency- -:0.00NA 2
    rs1858836741,2
    		--22992953(+) AACTCC/TCCCCA 1 -- ds50010--------
    rs1498309971,2
    		--22992965(+) ACCCCC/TACCGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TNFRSF10D (22993101 - 23021543 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for TNFRSF10D
         5 CNVs: 9597 31437 3726 9598 65083
         1 Inversion: 59850

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    Disorders / Diseases
    for TNFRSF10D gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TNFRSF10D for disorders           About GeneDecksing

    OMIM gene information: 603614    OMIM disorders: --

    20/58 diseases for TNFRSF10D (see all 58):    About MalaCards
    primary effusion lymphoma    laryngeal squamous cell carcinoma    squamous cell carcinoma    pancreatic ductal adenocarcinoma
    rhabdoid tumors    chronic lymphocytic leukemia    acute myeloid leukemia    epithelial ovarian cancer
    lymphocytic leukemia    myeloid leukemia    ulcerative colitis    cholecystitis
    malignant glioma    ovarian cancer    gallbladder carcinoma    colon carcinoma
    multiple myeloma    leukemia    prostate cancer    myelodysplastic syndrome

    10/17 Novoseek disease relationships for TNFRSF10D gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 74 22 16093247 (1), 18772312 (1), 11606398 (1), 11698291 (1) (see all 15)
    tumors 60.2 46 11929838 (5), 17570703 (2), 17569106 (2), 10548878 (1) (see all 26)
    cancer 47.6 3 16644104 (1), 18243765 (1)
    prostate cancer 33.8 13 17853923 (4), 11212279 (1), 16541419 (1), 14999791 (1)
    colon carcinoma 33.5 1 11245478 (1)
    ovarian cancer 30.3 3 16093247 (1), 12212122 (1), 14999791 (1)
    glioma 22.9 2 11221847 (1), 9613612 (1)
    osteosarcoma 20.4 1 12398939 (1)
    colon cancer 15.7 6 10933923 (3), 12473583 (1), 11245478 (1)
    metastasis 13.9 1 19147771 (1)

    Human Genome Epidemiology (HuGE) Navigator: TNFRSF10D (11 documents)

    Export disorders for TNFRSF10D gene to outside databases

    Publications
    for TNFRSF10D gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFRSF10D gene, integrated from 9 sources (see all 196):
    (articles sorted by number of sources associating them with TNFRSF10D)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. (PubMed id 9537512)1, 2, 3, 9 Pan G....Dixit V.M. (1998)
    2. A novel receptor for Apo2L/TRAIL contains a truncated death domain. (PubMed id 9382840)1, 2, 3, 9 Marsters S.A....Ashkenazi A. (1997)
    3. The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. (PubMed id 9430226)1, 2, 9 Degli-Esposti M.A....Goodwin R.G. (1997)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. DR5 and DcR2 are expressed in human lumbar interverte bral discs. (PubMed id 19730199)1, 9 Chen B....Hu Y. (2009)
    8. Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types. (PubMed id 14999791)1, 9 Shivapurkar N....Gazdar A.F. (2004)
    9. Hypoxia-induced decoy receptor 2 gene expression is r egulated via a hypoxia-inducible factor 1alpha-mediated mechanism. (PubMed id 20018172)1, 9 Pei G.T....Lin W.W. (2010)
    10. High TRAIL death receptor 4 and decoy receptor 2 expression correlates with significant cell death in pancreatic ductal adenocarcinoma patients. (PubMed id 18981952)1, 9 Sanlioglu A.D....Sanlioglu S. (2009)

    External Searches for TNFRSF10D gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing TNFRSF10D gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8793 HGNC: 11907 AceView: TNFRSF10D Ensembl:ENSG00000173530 euGenes: HUgn8793
    ECgene: TNFRSF10D Kegg: 8793 H-InvDB: TNFRSF10D

    Other Databases showing TNFRSF10D gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TNFRSF10D gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFRSF10D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF10D Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TNFRSF10D gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TNFRSF10D gene:
    Search GeneIP for patents involving TNFRSF10D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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