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Aliases for TNFRSF10D Gene

Aliases for TNFRSF10D Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy With Truncated Death Domain 2 3
  • TRAILR4 3 4 6
  • DCR2 3 4 6
  • TNF-Related Apoptosis-Inducing Ligand Receptor 4 3 4
  • TRAIL Receptor With A Truncated Death Domain 3 4
  • Decoy Receptor 2 3 4
  • TRAIL Receptor 4 3 4
  • TRAIL-R4 3 4
  • TRUNDD 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 10D 3
  • TNF Receptor-Related Receptor For TRAIL 3
  • CD264 Antigen 4
  • CD264 3

External Ids for TNFRSF10D Gene

Summaries for TNFRSF10D Gene

Entrez Gene Summary for TNFRSF10D Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF10D Gene

TNFRSF10D (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy With Truncated Death Domain) is a Protein Coding gene. Diseases associated with TNFRSF10D include prostate cancer. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include transmembrane signaling receptor activity and TRAIL binding. An important paralog of this gene is TNFRSF10C.

UniProtKB/Swiss-Prot for TNFRSF10D Gene

  • Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway

Gene Wiki entry for TNFRSF10D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF10D Gene

Genomics for TNFRSF10D Gene

Genomic Location for TNFRSF10D Gene

Start:
23,135,588 bp from pter
End:
23,164,030 bp from pter
Size:
28,443 bases
Orientation:
Minus strand

Genomic View for TNFRSF10D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF10D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF10D Gene

Regulatory Elements for TNFRSF10D Gene

Proteins for TNFRSF10D Gene

  • Protein details for TNFRSF10D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBN6-TR10D_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 10D
    Protein Accession:
    Q9UBN6
    Secondary Accessions:
    • B2R8W0
    • Q9Y6Q4

    Protein attributes for TNFRSF10D Gene

    Size:
    386 amino acids
    Molecular mass:
    41823 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TNFRSF10D Gene

Proteomics data for TNFRSF10D Gene at MOPED

Post-translational modifications for TNFRSF10D Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys241
  • Glycosylation at Asn127 and Asn182

Other Protein References for TNFRSF10D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFRSF10D Gene

Domains for TNFRSF10D Gene

Gene Families for TNFRSF10D Gene

HGNC:
  • CD :CD molecules
  • TNFRSF :Tumor necrosis factor receptor superfamily
IUPHAR :

Protein Domains for TNFRSF10D Gene

Blocks:
InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TR10D_HUMAN
Domain:
  • Contains 1 death domain.:
    • Q9UBN6
Similarity:
  • Contains 3 TNFR-Cys repeats.:
    • Q9UBN6
genes like me logo Genes that share domains with TNFRSF10D: view

Function for TNFRSF10D Gene

Molecular function for TNFRSF10D Gene

GENATLAS Biochemistry: tumor necrosis factor receptor superfamily,member 10C,abundant in fetal liver and adult testis,TNF related,TP53 inducible,apoptosis induced ligand (TRAIL) receptor 4,,binding APO2L,inducing NFKB and protecting against TRAIL-mediated apoptosis
UniProtKB/Swiss-Prot Function: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway

Gene Ontology (GO) - Molecular Function for TNFRSF10D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9430226
GO:0005515 protein binding --
GO:0045569 TRAIL binding IEA --
genes like me logo Genes that share ontologies with TNFRSF10D: view

miRNA for TNFRSF10D Gene

miRTarBase miRNAs that target TNFRSF10D

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TNFRSF10D Gene

Localization for TNFRSF10D Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF10D Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFRSF10D Gene COMPARTMENTS Subcellular localization image for TNFRSF10D gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TNFRSF10D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF10D: view

Pathways for TNFRSF10D Gene

genes like me logo Genes that share pathways with TNFRSF10D: view

Gene Ontology (GO) - Biological Process for TNFRSF10D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction TAS 9430226
GO:0043066 negative regulation of apoptotic process TAS 9430226
genes like me logo Genes that share ontologies with TNFRSF10D: view

Compounds for TNFRSF10D Gene

(8) Novoseek inferred chemical compound relationships for TNFRSF10D Gene

Compound -log(P) Hits PubMed IDs
tri (d) 83.9 4
doxorubicin 45.4 3
actinomycin d 27.5 1
5-aza-2deoxycytidine 23.7 1
cisplatin 21.1 1
genes like me logo Genes that share compounds with TNFRSF10D: view

Transcripts for TNFRSF10D Gene

mRNA/cDNA for TNFRSF10D Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(83) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFRSF10D Gene

Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF10D Gene

No ASD Table

Relevant External Links for TNFRSF10D Gene

GeneLoc Exon Structure for
TNFRSF10D
ECgene alternative splicing isoforms for
TNFRSF10D

Expression for TNFRSF10D Gene

mRNA expression in normal human tissues for TNFRSF10D Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNFRSF10D Gene

SOURCE GeneReport for Unigene cluster for TNFRSF10D Gene Hs.213467

mRNA Expression by UniProt/SwissProt for TNFRSF10D Gene

Q9UBN6-TR10D_HUMAN
Tissue specificity: Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart
genes like me logo Genes that share expressions with TNFRSF10D: view

Orthologs for TNFRSF10D Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF10D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF10D 36
  • 97.93 (n)
  • 94.56 (a)
TNFRSF10D 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 44 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
TNFRSF10D 37
  • 28 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tnfrsf10b 37
  • 25 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 16 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 21 (a)
OneToMany
chicken
(Gallus gallus)
Aves TVB 37
  • 20 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 17 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hdr 37
  • 15 (a)
ManyToMany
tnfrsfa 37
  • 14 (a)
ManyToMany
Species with no ortholog for TNFRSF10D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF10D Gene

ENSEMBL:
Gene Tree for TNFRSF10D (if available)
TreeFam:
Gene Tree for TNFRSF10D (if available)

Paralogs for TNFRSF10D Gene

Paralogs for TNFRSF10D Gene

Selected SIMAP similar genes for TNFRSF10D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNFRSF10D: view

Variants for TNFRSF10D Gene

Sequence variations from dbSNP and Humsavar for TNFRSF10D Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs7957 -- 23,135,854(+) CTCTC(C/T)GAGCT utr-variant-3-prime
rs1133782 - 23,144,475(-) AGAGT(C/T)GCCAG missense, reference
rs3924519 -- 23,147,116(+) TGACA(C/T)GTCTG intron-variant
rs4242391 -- 23,142,670(+) taaaa(C/T)cattc intron-variant
rs4278155 -- 23,139,266(+) GTTAC(A/C)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF10D Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
esv2736750 CNV Deletion 23290073
nsv520728 CNV Loss 19592680
esv8868 OTHER Inversion 19470904
nsv8326 CNV Gain 18304495
dgv68n64 CNV Gain 17921354
esv28117 CNV Gain 19812545
nsv818616 CNV Gain 17921354
esv2736753 CNV Deletion 23290073

Relevant External Links for TNFRSF10D Gene

HapMap Linkage Disequilibrium report
TNFRSF10D

Disorders for TNFRSF10D Gene

(1) MalaCards Diseases for TNFRSF10D Gene

Search for TNFRSF10D Gene in MalaCards »

(17) Novoseek inferred disease relationships for TNFRSF10D Gene

Disease -log(P) Hits PubMed IDs
necrosis 74 15
tumors 60.2 32
cancer 47.6 2
prostate cancer 33.8 7
colon carcinoma 33.5 1

Relevant External Links for TNFRSF10D

Genetic Association Database (GAD)
TNFRSF10D
Human Genome Epidemiology (HuGE) Navigator
TNFRSF10D
genes like me logo Genes that share disorders with TNFRSF10D: view

No data available for UniProtKB/Swiss-Prot for TNFRSF10D Gene

Publications for TNFRSF10D Gene

  1. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. (PMID: 9537512) Pan G. … Dixit V.M. (FEBS Lett. 1998) 2 3 4 23
  2. A novel receptor for Apo2L/TRAIL contains a truncated death domain. (PMID: 9382840) Marsters S.A. … Ashkenazi A. (Curr. Biol. 1997) 2 3 4 23
  3. The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. (PMID: 9430226) Degli-Esposti M.A. … Goodwin R.G. (Immunity 1997) 3 4 23
  4. Polymorphisms in TRAIL receptor genes and risk of breast cancer in Spanish women. (PMID: 17522430) Martinez-Ferrandis J.I. … Armengod M.E. (Cancer Biomark 2007) 3 23 49
  5. TRAIL-R4-beta: a new splice variant of TRAIL-receptor 4 lacking the cysteine rich domain 1. (PMID: 16934748) Krieg A. … Mahotka C. (Biochem. Biophys. Res. Commun. 2006) 3 23

Products for TNFRSF10D Gene

Sources for TNFRSF10D Gene

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