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Aliases for TNFRSF10D Gene

Aliases for TNFRSF10D Gene

  • TNF Receptor Superfamily Member 10d 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy With Truncated Death Domain 2 3
  • TNF-Related Apoptosis-Inducing Ligand Receptor 4 3 4
  • TRAIL Receptor With A Truncated Death Domain 3 4
  • Decoy Receptor 2 3 4
  • TRAIL Receptor 4 3 4
  • TRAIL-R4 3 4
  • TRAILR4 3 4
  • TRUNDD 3 4
  • DCR2 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 10D 3
  • TNF Receptor-Related Receptor For TRAIL 3
  • CD264 Antigen 4
  • CD264 3

External Ids for TNFRSF10D Gene

Previous GeneCards Identifiers for TNFRSF10D Gene

  • GC08M022763
  • GC08M023348
  • GC08M023016
  • GC08M023015
  • GC08M023049
  • GC08M022993
  • GC08M021537

Summaries for TNFRSF10D Gene

Entrez Gene Summary for TNFRSF10D Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF10D Gene

TNFRSF10D (TNF Receptor Superfamily Member 10d) is a Protein Coding gene. Diseases associated with TNFRSF10D include Prostate Cancer. Among its related pathways are Cell surface interactions at the vascular wall and Influenza A. GO annotations related to this gene include transmembrane signaling receptor activity and TRAIL binding. An important paralog of this gene is TNFRSF10B.

UniProtKB/Swiss-Prot for TNFRSF10D Gene

  • Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.

Gene Wiki entry for TNFRSF10D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF10D Gene

Genomics for TNFRSF10D Gene

Regulatory Elements for TNFRSF10D Gene

Enhancers for TNFRSF10D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F023159 1.4 FANTOM5 ENCODE 7.7 +1.6 1642 5.1 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENTPD4 ENSG00000253200 BIN3 CHMP7 TNFRSF10A LOC389641 ENSG00000250714 TNFRSF10C R3HCC1 LOC107986927
GH08F023350 1.5 FANTOM5 Ensembl ENCODE 2.8 -190.2 -190204 7.3 INSM2 SIN3A RAD21 RFX5 ZNF366 SCRT2 RCOR1 FOS EGR2 CEBPB LOXL2 ENTPD4 SLC25A37 TNFRSF10D LOC100507156 PIR45078
GH08F023174 1.5 FANTOM5 Ensembl ENCODE 2.7 -14.8 -14774 8.6 ATF1 ARID4B YY1 GTF3C2 GLIS2 FOS NFYC PPARG KAT8 RCOR2 ENSG00000253200 LOC389641 TNFRSF10A C8orf58 CHMP7 LOC107986927 ENSG00000250714 POLR3D R3HCC1 TNFRSF10C
GH08F023171 0.8 ENCODE 0.4 -7.7 -7729 0.8 HDGF PKNOX1 TAL1 BMI1 EBF1 NCOR1 NFYB EED ZNF143 ZNF207 CHMP7 R3HCC1 TNFRSF10D ENSG00000253930
GH08F023172 0.4 Ensembl 0.4 -9.0 -8971 0.4 ZBTB33 CHMP7 R3HCC1 TNFRSF10A TNFRSF10D ENSG00000253930
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFRSF10D on UCSC Golden Path with GeneCards custom track

Promoters for TNFRSF10D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001387767 1030 2801 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for TNFRSF10D Gene

Chromosome:
8
Start:
23,135,588 bp from pter
End:
23,164,030 bp from pter
Size:
28,443 bases
Orientation:
Minus strand

Genomic View for TNFRSF10D Gene

Genes around TNFRSF10D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF10D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF10D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF10D Gene

Proteins for TNFRSF10D Gene

  • Protein details for TNFRSF10D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBN6-TR10D_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 10D
    Protein Accession:
    Q9UBN6
    Secondary Accessions:
    • B2R8W0
    • Q9Y6Q4

    Protein attributes for TNFRSF10D Gene

    Size:
    386 amino acids
    Molecular mass:
    41823 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TNFRSF10D Gene

Post-translational modifications for TNFRSF10D Gene

  • Ubiquitination at Lys 241
  • Glycosylation at Asn 127 and Asn 182
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF10D Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFRSF10D (TRAIL R4/TNFRSF10D)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF10D (TRAIL-R4)
  • Abcam antibodies for TNFRSF10D
  • Santa Cruz Biotechnology (SCBT) Antibodies for TNFRSF10D

No data available for DME Specific Peptides for TNFRSF10D Gene

Domains & Families for TNFRSF10D Gene

Protein Domains for TNFRSF10D Gene

Suggested Antigen Peptide Sequences for TNFRSF10D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBN6

UniProtKB/Swiss-Prot:

TR10D_HUMAN :
  • Contains 1 death domain.
  • Contains 3 TNFR-Cys repeats.
Domain:
  • Contains 1 death domain.
Similarity:
  • Contains 3 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF10D: view

Function for TNFRSF10D Gene

Molecular function for TNFRSF10D Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 10C,abundant in fetal liver and adult testis,TNF related,TP53 inducible,apoptosis induced ligand (TRAIL) receptor 4,,binding APO2L,inducing NFKB and protecting against TRAIL-mediated apoptosis
UniProtKB/Swiss-Prot Function:
Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.

Gene Ontology (GO) - Molecular Function for TNFRSF10D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9430226
GO:0005031 tumor necrosis factor-activated receptor activity IBA --
GO:0045569 TRAIL binding IEA --
genes like me logo Genes that share ontologies with TNFRSF10D: view
genes like me logo Genes that share phenotypes with TNFRSF10D: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for TNFRSF10D (TRAIL R4/TNFRSF10D)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFRSF10D Gene

Localization for TNFRSF10D Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF10D Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF10D gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for TNFRSF10D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF10D: view

Pathways & Interactions for TNFRSF10D Gene

genes like me logo Genes that share pathways with TNFRSF10D: view

SIGNOR curated interactions for TNFRSF10D Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TNFRSF10D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007165 signal transduction TAS 9430226
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with TNFRSF10D: view

Drugs & Compounds for TNFRSF10D Gene

(5) Drugs for TNFRSF10D Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for TNFRSF10D Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF10D: view

Transcripts for TNFRSF10D Gene

mRNA/cDNA for TNFRSF10D Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(83) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFRSF10D Gene

Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for TNFRSF10D (TRAIL R4/TNFRSF10D)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF10D Gene

No ASD Table

Relevant External Links for TNFRSF10D Gene

GeneLoc Exon Structure for
TNFRSF10D
ECgene alternative splicing isoforms for
TNFRSF10D

Expression for TNFRSF10D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFRSF10D Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNFRSF10D Gene



NURSA nuclear receptor signaling pathways regulating expression of TNFRSF10D Gene:

TNFRSF10D

SOURCE GeneReport for Unigene cluster for TNFRSF10D Gene:

Hs.213467

mRNA Expression by UniProt/SwissProt for TNFRSF10D Gene:

Q9UBN6-TR10D_HUMAN
Tissue specificity: Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
genes like me logo Genes that share expression patterns with TNFRSF10D: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for TNFRSF10D Gene

Orthologs for TNFRSF10D Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF10D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF10D 34 35
  • 97.93 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 44 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
TNFRSF10D 35
  • 28 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tnfrsf10b 35
  • 25 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 21 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 16 (a)
OneToMany
chicken
(Gallus gallus)
Aves TVB 35
  • 20 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 17 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hdr 35
  • 15 (a)
ManyToMany
tnfrsfa 35
  • 14 (a)
ManyToMany
Species where no ortholog for TNFRSF10D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF10D Gene

ENSEMBL:
Gene Tree for TNFRSF10D (if available)
TreeFam:
Gene Tree for TNFRSF10D (if available)

Paralogs for TNFRSF10D Gene

Paralogs for TNFRSF10D Gene

(2) SIMAP similar genes for TNFRSF10D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNFRSF10D: view

Variants for TNFRSF10D Gene

Sequence variations from dbSNP and Humsavar for TNFRSF10D Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10087898 -- 23,160,178(+) CAGGA(C/T)TCACA intron-variant
rs10089445 -- 23,161,691(+) TAACA(A/G)TGTGA intron-variant
rs10089572 -- 23,161,777(+) GTGTG(A/G)ACTAG intron-variant
rs10092352 -- 23,161,669(+) ACCAT(G/T)AAGGA intron-variant
rs10092462 -- 23,161,701(+) ATGAA(C/T)CACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF10D Gene

Variant ID Type Subtype PubMed ID
nsv8326 CNV gain 18304495
nsv818616 CNV gain 17921354
nsv610775 CNV loss 21841781
nsv520728 CNV loss 19592680
nsv1068323 OTHER inversion 25765185
nsv1027718 CNV gain 25217958
nsv1025279 CNV loss 25217958
nsv1017570 CNV gain 25217958
esv8868 OTHER inversion 19470904
esv3616630 CNV gain 21293372
esv3616629 CNV gain 21293372
esv3616628 CNV loss 21293372
esv3616626 CNV gain 21293372
esv3572636 CNV loss 25503493
esv3333000 CNV duplication 20981092
esv28117 CNV gain 19812545
esv2759604 CNV loss 17122850
esv2736753 CNV deletion 23290073
esv2736750 CNV deletion 23290073
dgv68n64 CNV gain 17921354
dgv12057n54 CNV loss 21841781

Variation tolerance for TNFRSF10D Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.83; 79.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF10D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF10D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF10D Gene

Disorders for TNFRSF10D Gene

MalaCards: The human disease database

(1) MalaCards diseases for TNFRSF10D Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFRSF10D

Genetic Association Database (GAD)
TNFRSF10D
Human Genome Epidemiology (HuGE) Navigator
TNFRSF10D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFRSF10D
genes like me logo Genes that share disorders with TNFRSF10D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF10D Gene

Publications for TNFRSF10D Gene

  1. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. (PMID: 9537512) Pan G. … Dixit V.M. (FEBS Lett. 1998) 2 3 4 22 64
  2. A novel receptor for Apo2L/TRAIL contains a truncated death domain. (PMID: 9382840) Marsters S.A. … Ashkenazi A. (Curr. Biol. 1997) 2 3 4 22 64
  3. Polymorphisms in TRAIL receptor genes and risk of breast cancer in Spanish women. (PMID: 17522430) Martinez-Ferrandis J.I. … Armengod M.E. (Cancer Biomark 2007) 3 22 46 64
  4. The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. (PMID: 9430226) Degli-Esposti M.A. … Goodwin R.G. (Immunity 1997) 3 4 22 64
  5. Hypoxia-induced decoy receptor 2 gene expression is regulated via a hypoxia-inducible factor 1alpha-mediated mechanism. (PMID: 20018172) Pei G.T. … Lin W.W. (Biochem. Biophys. Res. Commun. 2010) 3 22 64

Products for TNFRSF10D Gene

Sources for TNFRSF10D Gene

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