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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF10C Gene

protein-coding   GIFtS: 60
GCID: GC08P022997

tumor necrosis factor receptor superfamily, member 10c,...

 Explore 60 diseases affiliated with
TNFRSF10C via our new
 Human Malady Compendium 
Biological research products
for TNFRSF10C
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An
Intracellular Domain1 2
     Lymphocyte Inhibitor Of TRAIL2 3
TRAILR31 2 3 5     TRAIL-R32 3
TRID1 2 3 5     TNF-Related Apoptosis-Inducing Ligand Receptor 32 3
LIT1 2 3     DCR1-TNFR2
DCR12 3 5     Cytotoxic TRAIL Receptor-32
CD2631 2     Tumor Necrosis Factor Receptor Superfamily Member 10C2
DcR11 3     CD263 Antigen3
Antagonist Decoy Receptor For TRAIL/Apo-2L2 3     TRAIL Receptor 33
Decoy Receptor 12 3     TRAIL Receptor Without An Intracellular Domain3
Decoy TRAIL Receptor Without Death Domain2 3     

External Ids:    HGNC: 119061   Entrez Gene: 87942   Ensembl: ENSG000001735357   OMIM: 6036135   UniProtKB: O147983   

Export aliases for TNFRSF10C gene to outside databases

Previous GC identifers: GC08P022711 GC08P023296 GC08P022781 GC08P022982 GC08P021504


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF10C:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular
TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of
inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced
apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was
detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of
cancer cells to the apoptosis-inducing activity of TRAIL. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TR10C_HUMAN, O14798
Function: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of
inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding
to the ligand

Gene Wiki entry for TNFRSF10C


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF10C gene promoter:
         CREB   STAT1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF10C promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF10C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF10C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22-p21   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p22-p21

TNFRSF10C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF10C gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P022997:  view genomic region     (about GC identifiers)

Start:
22,941,868 bp from pter      End:
22,974,950 bp from pter
Size:
33,083 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TR10C_HUMAN, O14798 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 10C precursor  
Size: 259 amino acids; 27407 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Sequence caution: Sequence=AAB71413.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAC05593.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAQ88648.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O14755 Q08AS6 Q6FH98 Q6UXM5

Explore the universe of human proteins at neXtProt for TNFRSF10C: NX_O14798

Post-translational modifications:

  • N-glycosylated and O-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14798

  • TNFRSF10C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003832.2  
    ENSEMBL proteins: 
     ENSP00000380815   ENSP00000349324   ENSP00000428235   ENSP00000437612  

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    Uscn Proteins for TNFRSF10C

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS9314565
    GO:0031225anchored to membrane IEA--


    TNFRSF10C for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TNFRSF10C for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR020465 TNFR_10

    Graphical View of Domain Structure for InterPro Entry O14798

    ProtoNet protein and cluster: O14798

    1 Blocks protein family: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TR10C_HUMAN, O14798
    Similarity: Contains 3 TNFR-Cys repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TR10C_HUMAN, O14798
    Function: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of
    inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding
    to the ligand

         Genatlas biochemistry entry for TNFRSF10C:
    tumor necrosis factor receptor superfamily,member 10C,expressed in peripheral lymphocytes and spleen,TNF
    related,apoptosis induced ligand (TRAIL) receptor 3,binding APO2L

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS9314565
    GO:0045569TRAIL binding IEA--


    TNFRSF10C for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/15 super-pathways (see all 15About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    STAT3 Pathway0.47
    Glucocorticoid Receptor Signaling0.27
    PGC1Alpha Pathway0.33
    Cytokine-cytokine receptor interaction0.26
    2TGF-Beta Pathway
    TGF-Beta Pathway1.00
    JNK Pathway0.50
    JAK-STAT Pathway0.57
    3Akt Signaling
    Akt Signaling1.00
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4Measles
    Measles1.00
    Influenza A0.35
    5TWEAK Pathway
    TRAIL Pathway0.40
    Apoptosis through Death Receptors0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TNFRSF10C
        Selected targets of ESR1

    1 R&D Systems Pathway for TNFRSF10C
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF10C (see all 14)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Glucocorticoid Receptor Signaling
    JAK-STAT Pathway

    1 Cell Signaling Technology (CST) Pathway for TNFRSF10C
        Apoptosis and Autophagy

    3 BioSystems Pathways for TNFRSF10C 
        Apoptosis Modulation and Signaling
    TRAIL signaling pathway
    Direct p53 effectors


    5         Kegg Pathways  (Kegg details for TNFRSF10C):
        Cytokine-cytokine receptor interaction
    Apoptosis
    Natural killer cell mediated cytotoxicity
    Measles
    Influenza A


    TNFRSF10C for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF10C

    5/8 Interacting proteins for TNFRSF10C (O147982, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOA1P026472, 3MINT-63077 I2D: score=5 
    FAM101BQ8N5W92, 3MINT-63078 I2D: score=5 
    ZHX1Q9UKY12, 3MINT-63079 I2D: score=5 
    LRSAM1Q6UWE02, 3MINT-64678 I2D: score=4 
    SLC27A6Q9Y2P42, 3MINT-65800 I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction TAS9314565


    TNFRSF10C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNFRSF10C for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFRSF10C
    10 Novoseek chemical compound relationships for TNFRSF10C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tri (d) 92.8 31 10435597 (8), 10811986 (5), 9242610 (4), 10933923 (2) (see all 7)
    actinomycin d 43.6 2 12430140 (1)
    doxorubicin 43 7 14623878 (5), 11090076 (1)
    cycloheximide 40.1 3 15219942 (2)
    5-aza-2'deoxycytidine 35.7 2 14999791 (1)
    etoposide 17.6 1 11090076 (1)
    lipid 5.13 1 16980609 (1)
    paclitaxel 4.85 1 11212279 (1)
    5fluorouracil 1.35 2 18755584 (2)
    phosphatidylinositol 0 3 11350953 (1), 9373179 (1)

    Search CenterWatch for drugs/clinical trials and news about TNFRSF10C / TR10C 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNFRSF10C gene: 
    NM_003841.3  

    Unigene Cluster for TNFRSF10C:

    Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
    Hs.655801  [show with all ESTs]
    Unigene Representative Sequence: NM_003841
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397703(uc003xcx.3) ENST00000520607 ENST00000356864(uc003xcy.3 uc011kzr.2)
    ENST00000517558 ENST00000518135 ENST00000540813

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    Additional cDNA sequence: 

    AF012536.1 AF012629.1 AF014794.1 AF016267.1 AF020502.1 AF033854.1 AK026079.1 AK298664.1 
    AK298718.1 AK313213.1 AY358281.1 BC017852.1 BC125041.1 BC125042.1 CR541857.1 

    3 DOTS entries:

    DT.112223  DT.97779046  DT.95363610 

    24/39 AceView cDNA sequences (see all 39):

    BC005043 CR541857 AL603419 AF012536 BC017852 BC021569 NM_003841 BE901975 
    AF016267 AW297198 AF033854 AU126850 AF012629 BF182836 AW237658 AF020502 
    BM564133 AY358281 AA861474 BM996302 AA150849 BG545631 AF014794 BI020428 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFRSF10C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TNFRSF10C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFRSF10C

    SOURCE GeneReport for Unigene cluster: Hs.655801

    UniProtKB/Swiss-Prot: TR10C_HUMAN, O14798
    Tissue specificity: Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood
    lymphocytes, spleen, skeletal muscle, placenta, lung and heart

        SABiosciences Expression via Pathway-Focused PCR Array including TNFRSF10C: 
              TNF Ligands & Receptors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF10C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF10C gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RHOBTB26
    LOC3789026
    Rho-related BTB domain containing 2
    death domain-containing tumor necrosis factor rece...
    14(a)
    13(a)
    1 ↔ many
    possible ortholog
    22(1282197-1286445)
    5(14153126-14162752)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    13(a)
    1 → many
    GL343679.1(101366-110435)
    zebrafish
    (Danio rerio)
    Actinopterygii tnfrsfa6
    hdr6
    hematopoietic death receptor
    13(a)
    12(a)
    many ↔ many
    many ↔ many
    21(14375999-14422468)
    5(29049495-29059630)


    ENSEMBL Gene Tree for TNFRSF10C (if available)
    TreeFam Gene Tree for TNFRSF10C (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFRSF10C gene
    TNFRSF10B2  FAS2  TNFRSF10A2  TNFRSF10D2  
    3 SIMAP similar genes for TNFRSF10C using alignment to 5 protein entries:     TR10C_HUMAN (see all proteins):
    TNFRSF10D    TNFRSF10A    TNFRSF10B

    TNFRSF10C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/364 NCBI SNPs in TNFRSF10C are shown (see all 364    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs43839651,2
    --21502548(+) tgtgcA/C/Gatcaa 1 -- us2k10--------
    rs735466351,2
    C,--21502815(+) GCTGCG/ATATAG 1 -- us2k12Minor allele frequency- A:0.21WA 120
    rs563821181,2
    C,--21502979(+) CTCTTC/TGGGGA 1 -- us2k12Minor allele frequency- T:0.03WA 120
    rs735466361,2
    C,--21502995(+) CTCCCC/TGTTAG 1 -- us2k12Minor allele frequency- T:0.12WA 120
    rs1155095051,2
    C,F,--21503119(+) CCTCTC/TAAATG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs42695441,2
    H--21503246(+) CTAGTC/ATACAC 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs749160091,2
    F,--21503773(+) CTGGAT/CAGACA 1 -- us2k11Minor allele frequency- C:0.18WA 118
    rs125447601,2
    C,F,H--21503969(+) GTGCCC/TGTCAT 1 -- us2k13Minor allele frequency- T:0.01NS NA 244
    rs735466381,2
    C,--21504539(+) CCTTTT/CCCCCC 1 -- ut512Minor allele frequency- C:0.13WA 120
    rs413081241,2
    C,F,--21504720(+) GCCCCG/TGCCGC 1 -- ut511Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for TNFRSF10C (22941868 - 22974950 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TNFRSF10C
         1 CNV: 3726
         1 Inversion: 59850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TNFRSF10C for disorders           About GeneDecksing

    OMIM gene information: 603613    OMIM disorders: --

    20/60 diseases for TNFRSF10C (see all 60):    About MalaCards
    churg-strauss syndrome    actinic keratosis    malignant mesothelioma    laryngeal squamous cell carcinoma
    systemic lupus erythematosus    squamous cell carcinoma    giant cell tumor    lupus erythematosus
    keratosis    rhabdoid tumors    chronic lymphocytic leukemia    acute myeloid leukemia
    epithelial ovarian cancer    lymphocytic leukemia    myeloid leukemia    ulcerative colitis
    malignant glioma    ovarian cancer    renal cell carcinoma    multiple myeloma

    10/18 Novoseek disease relationships for TNFRSF10C gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 71.1 19 15788647 (1), 14623878 (1), 9325248 (1), 11698291 (1) (see all 12)
    tumors 56.9 46 14623878 (3), 17569106 (3), 11929838 (3), 17570703 (2) (see all 25)
    cancer 43 9 16644104 (1), 14623878 (1), 10933923 (1), 17136491 (1) (see all 8)
    myeloma 34.5 2 11495702 (1)
    ovarian cancer 30.3 7 15931863 (2), 12212122 (2), 14984943 (2), 14999791 (1)
    malignant mesothelioma 22.5 1 14999791 (1)
    prostate cancer 19.8 2 16541419 (1), 14999791 (1)
    glioma 17.1 1 11221847 (1)
    adenoma 16 2 12473583 (1)
    colon cancer 15.7 3 18345033 (2), 12473583 (1)

    Human Genome Epidemiology (HuGE) Navigator: TNFRSF10C (7 documents)

    Export disorders for TNFRSF10C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFRSF10C gene, integrated from 9 sources (see all 194):
    (articles sorted by number of sources associating them with TNFRSF10C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. (PubMed id 9314565)1, 2, 3, 9 Degli-Esposti M.A.... Smith C.A. (1997)
    2. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. (PubMed id 9325248)1, 2, 3, 9 MacFarlane M.... Alnemri E.S. (1997)
    3. Characterization of two receptors for TRAIL. (PubMed id 9373179)1, 2, 9 Schneider P....Tschopp J. (1997)
    4. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. (PubMed id 9242610)1, 2, 9 Pan G.... Dixit V.M. (1997)
    5. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. (PubMed id 9242611)1, 2, 9 Sheridan J.P.... Ashkenazi A. (1997)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL. (PubMed id 9551946)1, 2 Mongkolsapaya J.... Screaton G.R. (1998)
    10. DcR1 expression in endometrial carcinomas. (PubMed id 19936781)1, 9 Tarragona J....Matias-Guiu X. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8794 HGNC: 11906 AceView: TNFRSF10C Ensembl:ENSG00000173535 euGenes: HUgn8794
    ECgene: TNFRSF10C Kegg: 8794 H-InvDB: TNFRSF10C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFRSF10C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF10C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNFRSF10C gene:
    Search GeneIP for patents involving TNFRSF10C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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