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Aliases for TNFRSF10C Gene

Aliases for TNFRSF10C Gene

  • TNF Receptor Superfamily Member 10c 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An Intracellular Domain 2 3
  • TNF-Related Apoptosis-Inducing Ligand Receptor 3 3 4
  • Antagonist Decoy Receptor For TRAIL/Apo-2L 3 4
  • Decoy TRAIL Receptor Without Death Domain 3 4
  • Lymphocyte Inhibitor Of TRAIL 3 4
  • Decoy Receptor 1 3 4
  • TRAIL-R3 3 4
  • TRAILR3 3 4
  • DCR1 3 4
  • TRID 3 4
  • LIT 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 10C 3
  • TRAIL Receptor Without An Intracellular Domain 4
  • Cytotoxic TRAIL Receptor-3 3
  • TRAIL Receptor 3 4
  • CD263 Antigen 4
  • DCR1-TNFR 3
  • CD263 3

External Ids for TNFRSF10C Gene

Previous GeneCards Identifiers for TNFRSF10C Gene

  • GC08P022711
  • GC08P023296
  • GC08P022781
  • GC08P022982
  • GC08P022997
  • GC08P021504

Summaries for TNFRSF10C Gene

Entrez Gene Summary for TNFRSF10C Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF10C Gene

TNFRSF10C (TNF Receptor Superfamily Member 10c) is a Protein Coding gene. Among its related pathways are TRAF Pathway and PEDF Induced Signaling. GO annotations related to this gene include transmembrane signaling receptor activity and TRAIL binding. An important paralog of this gene is TNFRSF10D.

UniProtKB/Swiss-Prot for TNFRSF10C Gene

  • Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

Gene Wiki entry for TNFRSF10C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF10C Gene

Genomics for TNFRSF10C Gene

Regulatory Elements for TNFRSF10C Gene

Enhancers for TNFRSF10C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G023525 1.5 FANTOM5 Ensembl ENCODE dbSUPER 32.5 +441.1 441144 0.6 CAVIN1 L3MBTL2 BHLHE40 NR4A1 CEBPB ZNF175 JUNB EBF1 ATF2 EED TNFRSF10C ENTPD4 SLC25A37 BIN3 LOC101929315 LOC105379327
GH08G023527 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.2 +446.3 446307 6.5 PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF143 TNFRSF10C SLC25A37 ENTPD4 BIN3 TNFRSF10B GC08M023551
GH08G023082 1.5 Ensembl ENCODE dbSUPER 14.8 -0.3 -344 2.1 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ENSG00000253616 TNFRSF10C LOXL2 LOC101929237 LOC254896
GH08G023159 1.7 FANTOM5 ENCODE dbSUPER 11.6 +78.0 78034 5.1 HDGF FOXA2 PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENTPD4 ENSG00000253200 BIN3 CHMP7 LOC389641 TNFRSF10A ENSG00000250714 TNFRSF10C R3HCC1 LOC107986927
GH08G023174 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +92.1 92138 3.9 KLF1 FOXA2 JUN ETV1 ZNF175 MAX SIN3A ZIC2 FOSL1 GTF3C2 ENSG00000253200 LOC389641 C8orf58 CHMP7 LOC107986927 TNFRSF10A ENSG00000250714 POLR3D R3HCC1 TNFRSF10C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFRSF10C on UCSC Golden Path with GeneCards custom track

Promoters for TNFRSF10C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000222168 486 1001 CTCF SUZ12 RBBP5 EBF1 ZBTB48 POLR2A EED ETV6 RELB IKZF2

Genomic Location for TNFRSF10C Gene

Chromosome:
8
Start:
23,084,355 bp from pter
End:
23,117,437 bp from pter
Size:
33,083 bases
Orientation:
Plus strand

Genomic View for TNFRSF10C Gene

Genes around TNFRSF10C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF10C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF10C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF10C Gene

Proteins for TNFRSF10C Gene

  • Protein details for TNFRSF10C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14798-TR10C_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 10C
    Protein Accession:
    O14798
    Secondary Accessions:
    • O14755
    • Q08AS6
    • Q6FH98
    • Q6UXM5

    Protein attributes for TNFRSF10C Gene

    Size:
    259 amino acids
    Molecular mass:
    27407 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB71413.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAC05593.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAQ88648.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TNFRSF10C Gene

Post-translational modifications for TNFRSF10C Gene

Other Protein References for TNFRSF10C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFRSF10C (TRAIL R3/TNFRSF10C)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF10C (TRAIL-R3)
  • Abcam antibodies for TNFRSF10C
  • Cloud-Clone Corp. Antibodies for TNFRSF10C
  • Santa Cruz Biotechnology (SCBT) Antibodies for TNFRSF10C

Protein Products

  • Cloud-Clone Corp. Proteins for TNFRSF10C
  • Abcam proteins for TNFRSF10C

Assay Products

  • Abcam assays for TNFRSF10C

No data available for DME Specific Peptides for TNFRSF10C Gene

Domains & Families for TNFRSF10C Gene

Protein Domains for TNFRSF10C Gene

Suggested Antigen Peptide Sequences for TNFRSF10C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFRSF10C: view

No data available for UniProtKB/Swiss-Prot for TNFRSF10C Gene

Function for TNFRSF10C Gene

Molecular function for TNFRSF10C Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 10C,expressed in peripheral lymphocytes and spleen,TNF related,apoptosis induced ligand (TRAIL) receptor 3,binding APO2L
UniProtKB/Swiss-Prot Function:
Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

Gene Ontology (GO) - Molecular Function for TNFRSF10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9314565
GO:0005031 tumor necrosis factor-activated receptor activity IBA --
GO:0045569 TRAIL binding IEA --
genes like me logo Genes that share ontologies with TNFRSF10C: view
genes like me logo Genes that share phenotypes with TNFRSF10C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for TNFRSF10C (TRAIL R3/TNFRSF10C)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TNFRSF10C Gene

Localization for TNFRSF10C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF10C Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF10C gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 2
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TNFRSF10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9314565
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF10C: view

Pathways & Interactions for TNFRSF10C Gene

genes like me logo Genes that share pathways with TNFRSF10C: view

SIGNOR curated interactions for TNFRSF10C Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TNFRSF10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007165 signal transduction TAS 9314565
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with TNFRSF10C: view

Drugs & Compounds for TNFRSF10C Gene

(4) Drugs for TNFRSF10C Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for TNFRSF10C Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF10C: view

Transcripts for TNFRSF10C Gene

Unigene Clusters for TNFRSF10C Gene

Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for TNFRSF10C (TRAIL R3/TNFRSF10C)

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF10C Gene

No ASD Table

Relevant External Links for TNFRSF10C Gene

GeneLoc Exon Structure for
TNFRSF10C
ECgene alternative splicing isoforms for
TNFRSF10C

Expression for TNFRSF10C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF10C Gene

mRNA differential expression in normal tissues according to GTEx for TNFRSF10C Gene

This gene is overexpressed in Whole Blood (x48.0).

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF10C Gene:

TNFRSF10C

SOURCE GeneReport for Unigene cluster for TNFRSF10C Gene:

Hs.655801

mRNA Expression by UniProt/SwissProt for TNFRSF10C Gene:

O14798-TR10C_HUMAN
Tissue specificity: Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Evidence on tissue expression from TISSUES for TNFRSF10C Gene

  • Spleen(4.4)
  • Liver(4.3)
  • Blood(3.7)
genes like me logo Genes that share expression patterns with TNFRSF10C: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF10C Gene

Orthologs for TNFRSF10C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF10C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF10C 34 35
  • 98.5 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 44 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
TNFRSF10D 35
  • 19 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 18 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tnfrsf10b 35
  • 16 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 10 (a)
OneToMany
chicken
(Gallus gallus)
Aves TVB 35
  • 14 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 15 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hdr 35
  • 12 (a)
ManyToMany
tnfrsfa 35
  • 11 (a)
ManyToMany
Species where no ortholog for TNFRSF10C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF10C Gene

ENSEMBL:
Gene Tree for TNFRSF10C (if available)
TreeFam:
Gene Tree for TNFRSF10C (if available)

Paralogs for TNFRSF10C Gene

Paralogs for TNFRSF10C Gene

(3) SIMAP similar genes for TNFRSF10C Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TNFRSF10C: view

Variants for TNFRSF10C Gene

Sequence variations from dbSNP and Humsavar for TNFRSF10C Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000030867 -- 23,113,769(+) TAAGA(A/T)CACTT intron-variant
rs1000355685 -- 23,115,969(+) GTCTG(C/G)GTTGT intron-variant
rs1000391350 -- 23,116,162(+) CCTCA(A/G)TAAGT intron-variant
rs1000615086 -- 23,117,492(+) CCCCT(C/T)CCTCA downstream-variant-500B
rs1000680125 -- 23,103,413(+) GCCCG(C/T)GAAGG intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF10C Gene

Variant ID Type Subtype PubMed ID
dgv12057n54 CNV loss 21841781
esv2736750 CNV deletion 23290073
esv2736752 CNV deletion 23290073
esv2759604 CNV loss 17122850
esv3616623 CNV loss 21293372
esv8868 OTHER inversion 19470904
nsv1015967 CNV loss 25217958
nsv1017570 CNV gain 25217958
nsv1025279 CNV loss 25217958
nsv1025672 CNV gain 25217958
nsv1027718 CNV gain 25217958
nsv520728 CNV loss 19592680
nsv610775 CNV loss 21841781
nsv971632 CNV duplication 23825009

Variation tolerance for TNFRSF10C Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF10C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF10C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF10C Gene

Disorders for TNFRSF10C Gene

Relevant External Links for TNFRSF10C

Genetic Association Database (GAD)
TNFRSF10C
Human Genome Epidemiology (HuGE) Navigator
TNFRSF10C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFRSF10C

No disorders were found for TNFRSF10C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFRSF10C Gene

Publications for TNFRSF10C Gene

  1. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. (PMID: 9314565) Degli-Esposti M.A. … Smith C.A. (J. Exp. Med. 1997) 2 3 4 22 64
  2. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. (PMID: 9325248) MacFarlane M. … Alnemri E.S. (J. Biol. Chem. 1997) 2 3 4 22 64
  3. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. (PMID: 9242610) Pan G. … Dixit V.M. (Science 1997) 3 4 22 64
  4. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. (PMID: 9242611) Sheridan J.P. … Ashkenazi A. (Science 1997) 3 4 22 64
  5. Characterization of two receptors for TRAIL. (PMID: 9373179) Schneider P. … Tschopp J. (FEBS Lett. 1997) 3 4 22 64

Products for TNFRSF10C Gene

Sources for TNFRSF10C Gene

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