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TNFRSF10C Gene

protein-coding   GIFtS: 62
GCID: GC08P022997

Tumor Necrosis Factor Receptor Superfamily, Member 10c,...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without
An Intracellular Domain1 2
     TNF-Related Apoptosis-Inducing Ligand Receptor 32 3
DCR12 3 5     CD2632
TRAILR32 3 5     DCR1-TNFR2
TRID2 3 5     Cytotoxic TRAIL Receptor-32
Antagonist Decoy Receptor For TRAIL/Apo-2L2 3     Tumor Necrosis Factor Receptor Superfamily Member 10C2
Decoy Receptor 12 3     DcR13
Decoy TRAIL Receptor Without Death Domain2 3     CD263 Antigen3
Lymphocyte Inhibitor Of TRAIL2 3     TRAIL Receptor 33
LIT2 3     TRAIL Receptor Without An Intracellular Domain3
TRAIL-R32 3     

External Ids:    HGNC: 119061   Entrez Gene: 87942   Ensembl: ENSG000001735357   OMIM: 6036135   UniProtKB: O147983   

Export aliases for TNFRSF10C gene to outside databases

Previous GC identifers: GC08P022711 GC08P023296 GC08P022781 GC08P022982 GC08P021504


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFRSF10C Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an
extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is
not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells
from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression
of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the
specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFRSF10C Gene:
TNFRSF10C (tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain) is a protein-coding gene. Diseases associated with TNFRSF10C include hypertrophic scars, and actinic keratosis. GO annotations related to this gene include transmembrane signaling receptor activity and TRAIL binding. An important paralog of this gene is TNFRSF10B.

UniProtKB/Swiss-Prot: TR10C_HUMAN, O14798
Function: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of
inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for
binding to the ligand

Gene Wiki entry for TNFRSF10C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFRSF10C gene promoter:
         CREB   STAT1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF10C promoter sequence
   Search Chromatin IP Primers for TNFRSF10C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF10C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22-p21   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p22-p21

TNFRSF10C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF10C gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P022997:  view genomic region     (about GC identifiers)

Start:
22,941,868 bp from pter      End:
22,974,950 bp from pter
Size:
33,083 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TR10C_HUMAN, O14798 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 10C precursor  
Size: 259 amino acids; 27407 Da
Sequence caution: Sequence=AAB71413.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAC05593.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAQ88648.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O14755 Q08AS6 Q6FH98 Q6UXM5

Explore the universe of human proteins at neXtProt for TNFRSF10C: NX_O14798

Explore proteomics data for TNFRSF10C at MOPED

Post-translational modifications: 

  • N-glycosylated and O-glycosylated1
  • Glycosylation2 at Asn77, Asn140, Asn156

  • See TNFRSF10C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003832.2  
    ENSEMBL proteins: 
     ENSP00000380815   ENSP00000349324   ENSP00000428235   ENSP00000437612  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: decoy receptor 1
    Tumour necrosis factor (TNF) receptor family

    2 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR020465 TNFR_10

    Graphical View of Domain Structure for InterPro Entry O14798

    ProtoNet protein and cluster: O14798

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TR10C_HUMAN, O14798
    Similarity: Contains 3 TNFR-Cys repeats


    TNFRSF10C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TR10C_HUMAN, O14798
    Function: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of
    inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for
    binding to the ligand

         Genatlas biochemistry entry for TNFRSF10C:
    tumor necrosis factor receptor superfamily,member 10C,expressed in peripheral lymphocytes and spleen,TNF
    related,apoptosis induced ligand (TRAIL) receptor 3,binding APO2L

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS9314565
    GO:0005515protein binding ----
    GO:0045569TRAIL binding IEA--
         
    TNFRSF10C for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TR10C_HUMAN, O14798: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS9314565
    GO:0031225anchored component of membrane IEA--

    TNFRSF10C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFRSF10C About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    PGC1Alpha Pathway0.51
    Glucocorticoid Receptor Signaling0.43
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    2TNF Signaling
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    NF-kB (NFkB) Pathway0.46
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    JAK-STAT Pathway0.57
    5TWEAK Pathway
    Apoptosis through Death Receptors0.42
    TRAIL Pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFRSF10C
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF10C (see all 14)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Glucocorticoid Receptor Signaling
    JAK-STAT Pathway

    1 Cell Signaling Technology (CST) Pathway for TNFRSF10C
        Apoptosis and Autophagy

    3 BioSystems Pathways for TNFRSF10C
        Apoptosis Modulation and Signaling
    TRAIL signaling pathway
    Direct p53 effectors

    1 Sino Biological Pathway for TNFRSF10C
        NF-kB (NFkB) Pathway


    5 Kegg Pathways  (Kegg details for TNFRSF10C):
        Cytokine-cytokine receptor interaction
    Apoptosis
    Natural killer cell mediated cytotoxicity
    Measles
    Influenza A


    TNFRSF10C for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including TNFRSF10C: 
              TNF Ligands & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFRSF10C

    Selected Interacting proteins for TNFRSF10C (O147982, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOA1P026472, 3MINT-63077 I2D: score=5 
    FAM101BQ8N5W92, 3MINT-63078 I2D: score=5 
    ZHX1Q9UKY12, 3MINT-63079 I2D: score=5 
    LRSAM1Q6UWE02, 3MINT-64678 I2D: score=4 
    SLC27A6Q9Y2P42, 3MINT-65800 I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction TAS9314565

    TNFRSF10C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFRSF10C (TR10C)

    10 Novoseek inferred chemical compound relationships for TNFRSF10C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tri (d) 92.8 31 10435597 (8), 10811986 (5), 9242610 (4), 10933923 (2) (see all 7)
    actinomycin d 43.6 2 12430140 (1)
    doxorubicin 43 7 14623878 (5), 11090076 (1)
    cycloheximide 40.1 3 15219942 (2)
    5-aza-2'deoxycytidine 35.7 2 14999791 (1)
    etoposide 17.6 1 11090076 (1)
    lipid 5.13 1 16980609 (1)
    paclitaxel 4.85 1 11212279 (1)
    5fluorouracil 1.35 2 18755584 (2)
    phosphatidylinositol 0 3 11350953 (1), 9373179 (1)



    TNFRSF10C for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TNFRSF10C gene: 
    NM_003841.3  

    Unigene Cluster for TNFRSF10C:

    Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
    Hs.655801  [show with all ESTs]
    Unigene Representative Sequence: NM_003841
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397703(uc003xcx.3) ENST00000520607 ENST00000356864(uc003xcy.3 uc011kzr.2)
    ENST00000517558 ENST00000518135 ENST00000540813
    miRNA
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    Additional mRNA sequence: 

    AF012536.1 AF012629.1 AF014794.1 AF016267.1 AF020502.1 AF033854.1 AK026079.1 AK298664.1 
    AK298718.1 AK313213.1 AY358281.1 BC017852.1 BC125041.1 BC125042.1 CR541857.1 

    3 DOTS entries:

    DT.112223  DT.97779046  DT.95363610 

    Selected AceView cDNA sequences (see all 39):

    CR541857 BC005043 AL603419 BF182836 AF012536 AF033854 AA861474 AW297198 
    NM_003841 AF012629 BC021569 AY358281 AU126850 BC017852 AF020502 AF016267 
    BM996302 BE901975 BM564133 AW237658 AU099549 AF014794 BG545631 AA150849 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFRSF10C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TNFRSF10C Expression
    About this image


    TNFRSF10C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    TNFRSF10C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFRSF10C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655801

    UniProtKB/Swiss-Prot: TR10C_HUMAN, O14798
    Tissue specificity: Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral
    blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart

        Pathway & Disease-focused RT2 Profiler PCR Array including TNFRSF10C: 
              TNF Ligands & Receptors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF10C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF10C gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TVB6
    Gallus gallus tumor necrosis factor receptor super...
    14(a)
    1 → many
    22(1270094-1276295)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    15(a)
    1 → many
    GL343679.1(101366-110435)
    zebrafish
    (Danio rerio)
    Actinopterygii hdr6
    tnfrsfa6
    hematopoietic death receptor
    tumor necrosis factor receptor superfamily, member...
    12(a)
    11(a)
    many ↔ many
    many ↔ many
    5(29049495-29059630) ENSDARG00000004392
    21(14375999-14422468) ENSDARG00000004451
            Species with no ortholog for TNFRSF10C

    ENSEMBL Gene Tree for TNFRSF10C (if available)
    TreeFam Gene Tree for TNFRSF10C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNFRSF10C gene
    TNFRSF10B2  TNFRSF10A2  TNFRSF10D2  
    3 SIMAP similar genes for TNFRSF10C using alignment to 5 protein entries:     TR10C_HUMAN (see all proteins):
    TNFRSF10D    TNFRSF10A    TNFRSF10B

    TNFRSF10C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFRSF10C (see all 443)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs675640071,2
    C--21507871(+) TGACC-/ACAGGG 1 -- int10--------
    rs341152511,2
    C--22964443(+) TTCAG-/AAAAAA 1 -- int10--------
    rs100815901,2
    C,F,H--22965775(+) cgcagC/Tcggac 1 -- int15Minor allele frequency- T:0.02NS EA WA 538
    rs569641291,2
    C--22968732(+) TTTTT-/TATTTG 1 -- int10--------
    rs58900891,2
    C,F--22969031(+) CTGTA-/T/TT  
            
    TTTTT
    1 -- int1 trp32NA 4
    rs715468491,2
    C--22970475(+) CTCCC-/CATCATCA 1 -- cds11Minor allele frequency- CAT:0.50NA 2
    rs1467840121,2
    C--22970476(+) TCCCC-/CATATCAT 1 -- cds10--------
    rs357147271,2
    C--22970477(+) CATCATCA/-ACACT 1 -- cds11Minor allele frequency- -:0.00NA 2
    rs43839651,2
    --23212519(+) tgtgcA/C/Gatcaa 1 -- us2k10--------
    rs1884218641,2
    --23212524(+) AATCAA/GCTTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TNFRSF10C (22941868 - 22974950 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TNFRSF10C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736750CNV Deletion23290073
    esv2736752CNV Deletion23290073
    nsv520728CNV Loss19592680
    essv19243CNV CNV17122850
    esv8868OTHER Inversion19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 603613    OMIM disorders: --

    Selected diseases for TNFRSF10C (see all 57):    
    About MalaCards
    hypertrophic scars    actinic keratosis    phaeochromocytoma    churg-strauss syndrome
    malignant mesothelioma    keratosis    rhabdoid tumor    giant cell tumor
    b-cell chronic lymphocytic leukemia    myeloma    laryngeal squamous cell carcinoma    chronic lymphocytic leukemia
    measles    multiple myeloma    pancreatic cancer    neutropenia
    laryngitis    oral cancer    ulcerative colitis    acute myeloid leukemia


    TNFRSF10C for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TNFRSF10C gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 71.1 19 15788647 (1), 14623878 (1), 9325248 (1), 11698291 (1) (see all 12)
    tumors 56.9 46 14623878 (3), 17569106 (3), 11929838 (3), 17570703 (2) (see all 25)
    cancer 43 9 16644104 (1), 14623878 (1), 10933923 (1), 17136491 (1) (see all 8)
    myeloma 34.5 2 11495702 (1)
    ovarian cancer 30.3 7 15931863 (2), 12212122 (2), 14984943 (2), 14999791 (1)
    malignant mesothelioma 22.5 1 14999791 (1)
    prostate cancer 19.8 2 16541419 (1), 14999791 (1)
    glioma 17.1 1 11221847 (1)
    adenoma 16 2 12473583 (1)
    colon cancer 15.7 3 18345033 (2), 12473583 (1)

    Genetic Association Database (GAD): TNFRSF10C
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF10C (7 documents)

    Export disorders for TNFRSF10C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFRSF10C gene, integrated from 10 sources (see all 196):
    (articles sorted by number of sources associating them with TNFRSF10C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. (PubMed id 9314565)1, 2, 3, 9 Degli-Esposti M.A.... Smith C.A. (J. Exp. Med. 1997)
    2. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. (PubMed id 9325248)1, 2, 3, 9 MacFarlane M.... Alnemri E.S. (J. Biol. Chem. 1997)
    3. Characterization of two receptors for TRAIL. (PubMed id 9373179)1, 2, 9 Schneider P....Tschopp J. (FEBS Lett. 1997)
    4. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. (PubMed id 9242610)1, 2, 9 Pan G.... Dixit V.M. (Science 1997)
    5. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. (PubMed id 9242611)1, 2, 9 Sheridan J.P.... Ashkenazi A. (Science 1997)
    6. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    7. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    8. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    9. Polymorphisms in TRAIL receptor genes and risk of breast cancer in Spanish women. (PubMed id 17522430)1, 4 Martinez-Ferrandis J.I....Armengod M.E. (Cancer Biomark 2007)
    10. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 8794 HGNC: 11906 AceView: TNFRSF10C Ensembl:ENSG00000173535 euGenes: HUgn8794
    ECgene: TNFRSF10C Kegg: 8794 H-InvDB: TNFRSF10C

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TNFRSF10C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF10C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TNFRSF10C gene:
    Search GeneIP for patents involving TNFRSF10C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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