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Aliases for TNFRSF10C Gene

Aliases for TNFRSF10C Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An Intracellular Domain 2 3
  • TRAILR3 3 4 6
  • DCR1 3 4 6
  • TRID 3 4 6
  • TNF-Related Apoptosis-Inducing Ligand Receptor 3 3 4
  • Antagonist Decoy Receptor For TRAIL/Apo-2L 3 4
  • Decoy TRAIL Receptor Without Death Domain 3 4
  • Lymphocyte Inhibitor Of TRAIL 3 4
  • Decoy Receptor 1 3 4
  • TRAIL-R3 3 4
  • LIT 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 10C 3
  • TRAIL Receptor Without An Intracellular Domain 4
  • Cytotoxic TRAIL Receptor-3 3
  • TRAIL Receptor 3 4
  • CD263 Antigen 4
  • DCR1-TNFR 3
  • CD263 3

External Ids for TNFRSF10C Gene

Previous GeneCards Identifiers for TNFRSF10C Gene

  • GC08P022711
  • GC08P023296
  • GC08P022781
  • GC08P022982
  • GC08P022997
  • GC08P021504

Summaries for TNFRSF10C Gene

Entrez Gene Summary for TNFRSF10C Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF10C Gene

TNFRSF10C (Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An Intracellular Domain) is a Protein Coding gene. Diseases associated with TNFRSF10C include pancreatic cancer and prostate cancer. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include transmembrane signaling receptor activity and TRAIL binding. An important paralog of this gene is TNFRSF10D.

UniProtKB/Swiss-Prot for TNFRSF10C Gene

  • Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand

Gene Wiki entry for TNFRSF10C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF10C Gene

Genomics for TNFRSF10C Gene

Regulatory Elements for TNFRSF10C Gene

Genomic Location for TNFRSF10C Gene

Start:
23,084,355 bp from pter
End:
23,117,437 bp from pter
Size:
33,083 bases
Orientation:
Plus strand

Genomic View for TNFRSF10C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF10C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF10C Gene

Proteins for TNFRSF10C Gene

  • Protein details for TNFRSF10C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14798-TR10C_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 10C
    Protein Accession:
    O14798
    Secondary Accessions:
    • O14755
    • Q08AS6
    • Q6FH98
    • Q6UXM5

    Protein attributes for TNFRSF10C Gene

    Size:
    259 amino acids
    Molecular mass:
    27407 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB71413.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAC05593.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAQ88648.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TNFRSF10C Gene

Proteomics data for TNFRSF10C Gene at MOPED

Post-translational modifications for TNFRSF10C Gene

Other Protein References for TNFRSF10C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFRSF10C Gene

Domains for TNFRSF10C Gene

Gene Families for TNFRSF10C Gene

HGNC:
  • CD :CD molecules
  • TNFRSF :Tumor necrosis factor receptor superfamily
IUPHAR :

Protein Domains for TNFRSF10C Gene

Suggested Antigen Peptide Sequences for TNFRSF10C Gene

Graphical View of Domain Structure for InterPro Entry

O14798

UniProtKB/Swiss-Prot:

TR10C_HUMAN :
  • O14798
Similarity:
  • Contains 3 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF10C: view

Function for TNFRSF10C Gene

Molecular function for TNFRSF10C Gene

GENATLAS Biochemistry: tumor necrosis factor receptor superfamily,member 10C,expressed in peripheral lymphocytes and spleen,TNF related,apoptosis induced ligand (TRAIL) receptor 3,binding APO2L
UniProtKB/Swiss-Prot Function: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand

Gene Ontology (GO) - Molecular Function for TNFRSF10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9314565
GO:0005515 protein binding --
GO:0045569 TRAIL binding IEA --
genes like me logo Genes that share ontologies with TNFRSF10C: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TNFRSF10C Gene

Localization for TNFRSF10C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF10C Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFRSF10C Gene COMPARTMENTS Subcellular localization image for TNFRSF10C gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 1

Gene Ontology (GO) - Cellular Components for TNFRSF10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9314565
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF10C: view

Pathways for TNFRSF10C Gene

genes like me logo Genes that share pathways with TNFRSF10C: view

Pathways by source for TNFRSF10C Gene

Interacting Proteins for TNFRSF10C Gene

Gene Ontology (GO) - Biological Process for TNFRSF10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction TAS 9314565
genes like me logo Genes that share ontologies with TNFRSF10C: view

Compounds for TNFRSF10C Gene

(10) Novoseek inferred chemical compound relationships for TNFRSF10C Gene

Compound -log(P) Hits PubMed IDs
tri (d) 92.8 22
actinomycin d 43.6 1
doxorubicin 43 6
cycloheximide 40.1 2
5-aza-2deoxycytidine 35.7 1
genes like me logo Genes that share compounds with TNFRSF10C: view

Transcripts for TNFRSF10C Gene

Unigene Clusters for TNFRSF10C Gene

Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF10C Gene

No ASD Table

Relevant External Links for TNFRSF10C Gene

GeneLoc Exon Structure for
TNFRSF10C
ECgene alternative splicing isoforms for
TNFRSF10C

Expression for TNFRSF10C Gene

mRNA expression in normal human tissues for TNFRSF10C Gene

mRNA differential expression in normal tissues according to GTEx for TNFRSF10C Gene

This gene is overexpressed in Whole Blood (48.0).

SOURCE GeneReport for Unigene cluster for TNFRSF10C Gene Hs.655801

mRNA Expression by UniProt/SwissProt for TNFRSF10C Gene

O14798-TR10C_HUMAN
Tissue specificity: Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart
genes like me logo Genes that share expressions with TNFRSF10C: view

No data available for Protein expression for TNFRSF10C Gene

Orthologs for TNFRSF10C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF10C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF10C 35
  • 98.5 (n)
  • 96.72 (a)
TNFRSF10C 36
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 44 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
TNFRSF10D 36
  • 19 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tnfrsf10b 36
  • 16 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 10 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 18 (a)
OneToMany
chicken
(Gallus gallus)
Aves TVB 36
  • 14 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 15 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hdr 36
  • 12 (a)
ManyToMany
tnfrsfa 36
  • 11 (a)
ManyToMany
Species with no ortholog for TNFRSF10C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF10C Gene

ENSEMBL:
Gene Tree for TNFRSF10C (if available)
TreeFam:
Gene Tree for TNFRSF10C (if available)

Paralogs for TNFRSF10C Gene

Paralogs for TNFRSF10C Gene

Selected SIMAP similar genes for TNFRSF10C Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TNFRSF10C: view

Variants for TNFRSF10C Gene

Sequence variations from dbSNP and Humsavar for TNFRSF10C Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs4077341 -- 23,104,835(+) CAGGG(G/T)ATCCA intron-variant
rs4242389 -- 23,114,808(+) GGAGC(A/G)TGGGG intron-variant
rs4620285 -- 23,106,269(+) ACCCT(C/T)GCCTC intron-variant
rs4871847 -- 23,106,803(+) aacac(A/G)gtgaa intron-variant
rs4871848 -- 23,106,916(+) tggga(A/G)gcaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF10C Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
esv2736750 CNV Deletion 23290073
esv2736752 CNV Deletion 23290073
nsv520728 CNV Loss 19592680
esv8868 OTHER Inversion 19470904

Relevant External Links for TNFRSF10C Gene

HapMap Linkage Disequilibrium report
TNFRSF10C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF10C Gene

Disorders for TNFRSF10C Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TNFRSF10C Gene including...

Search for TNFRSF10C Gene in MalaCards »

(18) Novoseek inferred disease relationships for TNFRSF10C Gene

Disease -log(P) Hits PubMed IDs
necrosis 71.1 12
tumors 56.9 34
cancer 43 8
myeloma 34.5 1
ovarian cancer 30.3 7

Relevant External Links for TNFRSF10C

Genetic Association Database (GAD)
TNFRSF10C
Human Genome Epidemiology (HuGE) Navigator
TNFRSF10C
genes like me logo Genes that share disorders with TNFRSF10C: view

No data available for UniProtKB/Swiss-Prot for TNFRSF10C Gene

Publications for TNFRSF10C Gene

  1. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. (PMID: 9314565) Degli-Esposti M.A. … Smith C.A. (J. Exp. Med. 1997) 2 3 4 23
  2. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. (PMID: 9325248) MacFarlane M. … Alnemri E.S. (J. Biol. Chem. 1997) 2 3 4 23
  3. Characterization of two receptors for TRAIL. (PMID: 9373179) Schneider P. … Tschopp J. (FEBS Lett. 1997) 3 4 23
  4. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. (PMID: 9242610) Pan G. … Dixit V.M. (Science 1997) 3 4 23
  5. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. (PMID: 9242611) Sheridan J.P. … Ashkenazi A. (Science 1997) 3 4 23

Products for TNFRSF10C Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • TNF Ligands & Receptors in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TNFRSF10C
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF10C
    • Block miRNA regulation of TNFRSF10C using miScript Target Protectors

    Sources for TNFRSF10C Gene

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