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Aliases for TNFRSF10C Gene

Aliases for TNFRSF10C Gene

  • Tumor Necrosis Factor Receptor Superfamily Member 10c 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An Intracellular Domain 2 3
  • TNF-Related Apoptosis-Inducing Ligand Receptor 3 3 4
  • Antagonist Decoy Receptor For TRAIL/Apo-2L 3 4
  • Decoy TRAIL Receptor Without Death Domain 3 4
  • Lymphocyte Inhibitor Of TRAIL 3 4
  • Decoy Receptor 1 3 4
  • TRAIL-R3 3 4
  • TRAILR3 3 4
  • DCR1 3 4
  • TRID 3 4
  • LIT 3 4
  • TRAIL Receptor Without An Intracellular Domain 4
  • Cytotoxic TRAIL Receptor-3 3
  • TRAIL Receptor 3 4
  • CD263 Antigen 4
  • DCR1-TNFR 3
  • CD263 3

External Ids for TNFRSF10C Gene

Previous GeneCards Identifiers for TNFRSF10C Gene

  • GC08P022711
  • GC08P023296
  • GC08P022781
  • GC08P022982
  • GC08P022997
  • GC08P021504

Summaries for TNFRSF10C Gene

Entrez Gene Summary for TNFRSF10C Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF10C Gene

TNFRSF10C (Tumor Necrosis Factor Receptor Superfamily Member 10c) is a Protein Coding gene. Among its related pathways are Gene Expression and ERK Signaling. GO annotations related to this gene include transmembrane signaling receptor activity and TRAIL binding. An important paralog of this gene is TNFRSF10D.

UniProtKB/Swiss-Prot for TNFRSF10C Gene

  • Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

Gene Wiki entry for TNFRSF10C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF10C Gene

Genomics for TNFRSF10C Gene

Regulatory Elements for TNFRSF10C Gene

Promoters for TNFRSF10C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNFRSF10C on UCSC Golden Path with GeneCards custom track

Genomic Location for TNFRSF10C Gene

Chromosome:
8
Start:
23,084,355 bp from pter
End:
23,117,437 bp from pter
Size:
33,083 bases
Orientation:
Plus strand

Genomic View for TNFRSF10C Gene

Genes around TNFRSF10C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF10C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF10C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF10C Gene

Proteins for TNFRSF10C Gene

  • Protein details for TNFRSF10C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14798-TR10C_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 10C
    Protein Accession:
    O14798
    Secondary Accessions:
    • O14755
    • Q08AS6
    • Q6FH98
    • Q6UXM5

    Protein attributes for TNFRSF10C Gene

    Size:
    259 amino acids
    Molecular mass:
    27407 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB71413.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAC05593.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAQ88648.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TNFRSF10C Gene

Proteomics data for TNFRSF10C Gene at MOPED

Post-translational modifications for TNFRSF10C Gene

Other Protein References for TNFRSF10C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFRSF10C (TRAIL R3/TNFRSF10C)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF10C (TRAIL-R3)
  • Cloud-Clone Corp. Antibodies for TNFRSF10C

No data available for DME Specific Peptides for TNFRSF10C Gene

Domains & Families for TNFRSF10C Gene

Protein Domains for TNFRSF10C Gene

Suggested Antigen Peptide Sequences for TNFRSF10C Gene

Graphical View of Domain Structure for InterPro Entry

O14798

UniProtKB/Swiss-Prot:

TR10C_HUMAN :
  • Contains 3 TNFR-Cys repeats.
Similarity:
  • Contains 3 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF10C: view

Function for TNFRSF10C Gene

Molecular function for TNFRSF10C Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 10C,expressed in peripheral lymphocytes and spleen,TNF related,apoptosis induced ligand (TRAIL) receptor 3,binding APO2L
UniProtKB/Swiss-Prot Function:
Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

Gene Ontology (GO) - Molecular Function for TNFRSF10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TNFRSF10C: view
genes like me logo Genes that share phenotypes with TNFRSF10C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for TNFRSF10C (TRAIL R3/TNFRSF10C)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TNFRSF10C Gene

Localization for TNFRSF10C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF10C Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFRSF10C Gene COMPARTMENTS Subcellular localization image for TNFRSF10C gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 2
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for TNFRSF10C Gene

Pathways & Interactions for TNFRSF10C Gene

genes like me logo Genes that share pathways with TNFRSF10C: view

Interacting Proteins for TNFRSF10C Gene

SIGNOR curated interactions for TNFRSF10C Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TNFRSF10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9314565
GO:0007275 multicellular organism development IBA --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IBA --
GO:0032496 response to lipopolysaccharide IBA --
GO:0033209 tumor necrosis factor-mediated signaling pathway IBA --
genes like me logo Genes that share ontologies with TNFRSF10C: view

Drugs & Compounds for TNFRSF10C Gene

(3) Drugs for TNFRSF10C Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for TNFRSF10C Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF10C: view

Transcripts for TNFRSF10C Gene

Unigene Clusters for TNFRSF10C Gene

Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for TNFRSF10C (TRAIL R3/TNFRSF10C)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF10C Gene

No ASD Table

Relevant External Links for TNFRSF10C Gene

GeneLoc Exon Structure for
TNFRSF10C
ECgene alternative splicing isoforms for
TNFRSF10C

Expression for TNFRSF10C Gene

mRNA expression in normal human tissues for TNFRSF10C Gene

mRNA differential expression in normal tissues according to GTEx for TNFRSF10C Gene

This gene is overexpressed in Whole Blood (x48.0).

SOURCE GeneReport for Unigene cluster for TNFRSF10C Gene Hs.655801

mRNA Expression by UniProt/SwissProt for TNFRSF10C Gene

O14798-TR10C_HUMAN
Tissue specificity: Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.
genes like me logo Genes that share expression patterns with TNFRSF10C: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TNFRSF10C Gene

Orthologs for TNFRSF10C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF10C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF10C 36
  • 84 (a)
OneToOne
TNFRSF10C 35
  • 98.5 (n)
  • 96.72 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 44 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
TNFRSF10D 36
  • 19 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tnfrsf10b 36
  • 16 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 10 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 18 (a)
OneToMany
chicken
(Gallus gallus)
Aves TVB 36
  • 14 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 15 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hdr 36
  • 12 (a)
ManyToMany
tnfrsfa 36
  • 11 (a)
ManyToMany
Species with no ortholog for TNFRSF10C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF10C Gene

ENSEMBL:
Gene Tree for TNFRSF10C (if available)
TreeFam:
Gene Tree for TNFRSF10C (if available)

Paralogs for TNFRSF10C Gene

Paralogs for TNFRSF10C Gene

(3) SIMAP similar genes for TNFRSF10C Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TNFRSF10C: view

Variants for TNFRSF10C Gene

Sequence variations from dbSNP and Humsavar for TNFRSF10C Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs12550828 - 23,116,847(+) AATGA(A/C)CACCA reference, missense
rs9644063 - 23,116,937(+) AATGA(A/C/T)CACCA reference, missense
rs4242389 -- 23,114,808(+) GGAGC(A/G/T)TGGGG intron-variant
rs4620285 -- 23,106,269(+) ACCCT(C/T)GCCTC intron-variant
rs4871849 -- 23,107,206(+) AAACA(A/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF10C Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
esv2736750 CNV Deletion 23290073
esv2736752 CNV Deletion 23290073
nsv520728 CNV Loss 19592680
esv8868 OTHER Inversion 19470904

Variation tolerance for TNFRSF10C Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF10C Gene

HapMap Linkage Disequilibrium report
TNFRSF10C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF10C Gene

Disorders for TNFRSF10C Gene

Relevant External Links for TNFRSF10C

Genetic Association Database (GAD)
TNFRSF10C
Human Genome Epidemiology (HuGE) Navigator
TNFRSF10C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFRSF10C

No disorders were found for TNFRSF10C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFRSF10C Gene

Publications for TNFRSF10C Gene

  1. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. (PMID: 9314565) Degli-Esposti M.A. … Smith C.A. (J. Exp. Med. 1997) 2 3 4 23 67
  2. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. (PMID: 9325248) MacFarlane M. … Alnemri E.S. (J. Biol. Chem. 1997) 2 3 23
  3. DcR1 expression in endometrial carcinomas. (PMID: 19936781) Tarragona J. … Matias-Guiu X. (Virchows Arch. 2010) 3 23
  4. P53-mediated upregulation of DcR1 impairs oxaliplatin/TRAIL-induced synergistic anti-tumour potential in colon cancer cells. (PMID: 18345033) Toscano F. … Saurin J.C. (Oncogene 2008) 3 23
  5. Protein phosphatase and TRAIL receptor genes as new candidate tumor genes on chromosome 8p in prostate cancer. (PMID: 18460741) Hornstein M. … Schulz W.A. (Cancer Genomics Proteomics 2008) 3 23

Products for TNFRSF10C Gene

Sources for TNFRSF10C Gene

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