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Aliases for TNFRSF10C Gene

Aliases for TNFRSF10C Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An Intracellular Domain 2 3
  • TRAILR3 3 4 6
  • DCR1 3 4 6
  • TRID 3 4 6
  • TNF-Related Apoptosis-Inducing Ligand Receptor 3 3 4
  • Antagonist Decoy Receptor For TRAIL/Apo-2L 3 4
  • Decoy TRAIL Receptor Without Death Domain 3 4
  • Lymphocyte Inhibitor Of TRAIL 3 4
  • Decoy Receptor 1 3 4
  • TRAIL-R3 3 4
  • LIT 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 10C 3
  • TRAIL Receptor Without An Intracellular Domain 4
  • Cytotoxic TRAIL Receptor-3 3
  • TRAIL Receptor 3 4
  • CD263 Antigen 4
  • DCR1-TNFR 3
  • CD263 3

External Ids for TNFRSF10C Gene

Previous GeneCards Identifiers for TNFRSF10C Gene

  • GC08P022711
  • GC08P023296
  • GC08P022781
  • GC08P022982
  • GC08P022997
  • GC08P021504

Summaries for TNFRSF10C Gene

Entrez Gene Summary for TNFRSF10C Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF10C Gene

TNFRSF10C (Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An Intracellular Domain) is a Protein Coding gene. Diseases associated with TNFRSF10C include pancreatic cancer and prostate cancer. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include transmembrane signaling receptor activity and TRAIL binding. An important paralog of this gene is TNFRSF10D.

UniProtKB/Swiss-Prot for TNFRSF10C Gene

  • Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand

Gene Wiki entry for TNFRSF10C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF10C Gene

Genomics for TNFRSF10C Gene

Regulatory Elements for TNFRSF10C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNFRSF10C Gene

Start:
23,084,355 bp from pter
End:
23,117,437 bp from pter
Size:
33,083 bases
Orientation:
Plus strand

Genomic View for TNFRSF10C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF10C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF10C Gene

Proteins for TNFRSF10C Gene

  • Protein details for TNFRSF10C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14798-TR10C_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 10C
    Protein Accession:
    O14798
    Secondary Accessions:
    • O14755
    • Q08AS6
    • Q6FH98
    • Q6UXM5

    Protein attributes for TNFRSF10C Gene

    Size:
    259 amino acids
    Molecular mass:
    27407 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB71413.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAC05593.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAQ88648.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TNFRSF10C Gene

Proteomics data for TNFRSF10C Gene at MOPED

Post-translational modifications for TNFRSF10C Gene

Other Protein References for TNFRSF10C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFRSF10C (TRAIL R3/TNFRSF10C)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF10C (TRAIL-R3)

Protein Products

  • Enzo Life Sciences proteins for TNFRSF10C
  • Cloud-Clone Corp. Proteins for TNFRSF10C

No data available for DME Specific Peptides for TNFRSF10C Gene

Domains for TNFRSF10C Gene

Gene Families for TNFRSF10C Gene

HGNC:
  • CD :CD molecules
  • TNFRSF :Tumor necrosis factor receptor superfamily
IUPHAR :

Protein Domains for TNFRSF10C Gene

Suggested Antigen Peptide Sequences for TNFRSF10C Gene

Graphical View of Domain Structure for InterPro Entry

O14798

UniProtKB/Swiss-Prot:

TR10C_HUMAN :
  • O14798
Similarity:
  • Contains 3 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF10C: view

Function for TNFRSF10C Gene

Molecular function for TNFRSF10C Gene

GENATLAS Biochemistry: tumor necrosis factor receptor superfamily,member 10C,expressed in peripheral lymphocytes and spleen,TNF related,apoptosis induced ligand (TRAIL) receptor 3,binding APO2L
UniProtKB/Swiss-Prot Function: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand

Gene Ontology (GO) - Molecular Function for TNFRSF10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9314565
GO:0005515 protein binding --
GO:0045569 TRAIL binding IEA --
genes like me logo Genes that share ontologies with TNFRSF10C: view

Animal Model Products

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate TNFRSF10C
    • Block miRNA regulation of TNFRSF10C using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF10C

    Clone Products

    • R&D Systems cDNA Clones for TNFRSF10C (TRAIL R3/TNFRSF10C)

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TNFRSF10C Gene

    Localization for TNFRSF10C Gene

    Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF10C Gene

    Cell membrane; Lipid-anchor, GPI-anchor.

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for TNFRSF10C Gene COMPARTMENTS Subcellular localization image for TNFRSF10C gene
    Compartment Confidence
    plasma membrane 5
    extracellular 3
    cytosol 1

    Gene Ontology (GO) - Cellular Components for TNFRSF10C Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0005887 integral component of plasma membrane TAS 9314565
    GO:0031225 anchored component of membrane IEA --
    genes like me logo Genes that share ontologies with TNFRSF10C: view

    Pathways for TNFRSF10C Gene

    genes like me logo Genes that share pathways with TNFRSF10C: view

    Pathways by source for TNFRSF10C Gene

    PCR Array Products

    • Pathway & Disease-focused RT² Profiler PCR Arrays
      • TNF Ligands & Receptors in human,mouse,rat

    Interacting Proteins for TNFRSF10C Gene

    Gene Ontology (GO) - Biological Process for TNFRSF10C Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0006915 apoptotic process IEA --
    GO:0007165 signal transduction TAS 9314565
    genes like me logo Genes that share ontologies with TNFRSF10C: view

    Compounds for TNFRSF10C Gene

    (10) Novoseek inferred chemical compound relationships for TNFRSF10C Gene

    Compound -log(P) Hits PubMed IDs
    tri (d) 92.8 22
    actinomycin d 43.6 1
    doxorubicin 43 6
    cycloheximide 40.1 2
    5-aza-2deoxycytidine 35.7 1
    genes like me logo Genes that share compounds with TNFRSF10C: view

    Transcripts for TNFRSF10C Gene

    Unigene Clusters for TNFRSF10C Gene

    Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain:
    Representative Sequences:

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate TNFRSF10C
      • Block miRNA regulation of TNFRSF10C using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF10C

      Clone Products

      • R&D Systems cDNA Clones for TNFRSF10C (TRAIL R3/TNFRSF10C)

      Primer Products

      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF10C Gene

      No ASD Table

      Relevant External Links for TNFRSF10C Gene

      GeneLoc Exon Structure for
      TNFRSF10C
      ECgene alternative splicing isoforms for
      TNFRSF10C

      Expression for TNFRSF10C Gene

      mRNA expression in normal human tissues for TNFRSF10C Gene

      mRNA differential expression in normal tissues according to GTEx for TNFRSF10C Gene

      This gene is overexpressed in Whole Blood (48.0).

      SOURCE GeneReport for Unigene cluster for TNFRSF10C Gene Hs.655801

      mRNA Expression by UniProt/SwissProt for TNFRSF10C Gene

      O14798-TR10C_HUMAN
      Tissue specificity: Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart
      genes like me logo Genes that share expressions with TNFRSF10C: view

      In Situ Assay Products

      No data available for Protein expression for TNFRSF10C Gene

      Orthologs for TNFRSF10C Gene

      This gene was present in the common ancestor of chordates.

      Orthologs for TNFRSF10C Gene

      Organism Taxonomy Gene Similarity Type Details
      chimpanzee
      (Pan troglodytes)
      Mammalia TNFRSF10C 35
      • 98.5 (n)
      • 96.72 (a)
      TNFRSF10C 36
      • 84 (a)
      OneToOne
      cow
      (Bos Taurus)
      Mammalia -- 36
      • 44 (a)
      ManyToMany
      -- 36
      • 41 (a)
      ManyToMany
      TNFRSF10D 36
      • 19 (a)
      ManyToMany
      mouse
      (Mus musculus)
      Mammalia Tnfrsf10b 36
      • 16 (a)
      OneToMany
      oppossum
      (Monodelphis domestica)
      Mammalia -- 36
      • 10 (a)
      OneToMany
      platypus
      (Ornithorhynchus anatinus)
      Mammalia -- 36
      • 18 (a)
      OneToMany
      chicken
      (Gallus gallus)
      Aves TVB 36
      • 14 (a)
      OneToMany
      lizard
      (Anolis carolinensis)
      Reptilia -- 36
      • 15 (a)
      OneToMany
      zebrafish
      (Danio rerio)
      Actinopterygii hdr 36
      • 12 (a)
      ManyToMany
      tnfrsfa 36
      • 11 (a)
      ManyToMany
      Species with no ortholog for TNFRSF10C:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • dog (Canis familiaris)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • rainbow trout (Oncorhynchus mykiss)
      • rat (Rattus norvegicus)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)

      Evolution for TNFRSF10C Gene

      ENSEMBL:
      Gene Tree for TNFRSF10C (if available)
      TreeFam:
      Gene Tree for TNFRSF10C (if available)

      Paralogs for TNFRSF10C Gene

      Paralogs for TNFRSF10C Gene

      Selected SIMAP similar genes for TNFRSF10C Gene using alignment to 5 proteins:

      genes like me logo Genes that share paralogs with TNFRSF10C: view

      Variants for TNFRSF10C Gene

      Sequence variations from dbSNP and Humsavar for TNFRSF10C Gene

      SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
      rs4077341 -- 23,104,835(+) CAGGG(G/T)ATCCA intron-variant
      rs4242389 -- 23,114,808(+) GGAGC(A/G)TGGGG intron-variant
      rs4620285 -- 23,106,269(+) ACCCT(C/T)GCCTC intron-variant
      rs4871847 -- 23,106,803(+) aacac(A/G)gtgaa intron-variant
      rs4871848 -- 23,106,916(+) tggga(A/G)gcaga intron-variant

      Structural Variations from Database of Genomic Variants (DGV) for TNFRSF10C Gene

      Variant ID Type Subtype PubMed ID
      essv19243 CNV CNV 17122850
      esv2736750 CNV Deletion 23290073
      esv2736752 CNV Deletion 23290073
      nsv520728 CNV Loss 19592680
      esv8868 OTHER Inversion 19470904

      Relevant External Links for TNFRSF10C Gene

      HapMap Linkage Disequilibrium report
      TNFRSF10C

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF10C Gene

      Disorders for TNFRSF10C Gene

      MalaCards: The human disease database

      MalaCards: The human disease database. (2) Diseases for TNFRSF10C Gene including...

      Search for TNFRSF10C Gene in MalaCards »

      (18) Novoseek inferred disease relationships for TNFRSF10C Gene

      Disease -log(P) Hits PubMed IDs
      necrosis 71.1 12
      tumors 56.9 34
      cancer 43 8
      myeloma 34.5 1
      ovarian cancer 30.3 7

      Relevant External Links for TNFRSF10C

      Genetic Association Database (GAD)
      TNFRSF10C
      Human Genome Epidemiology (HuGE) Navigator
      TNFRSF10C
      genes like me logo Genes that share disorders with TNFRSF10C: view

      No data available for UniProtKB/Swiss-Prot for TNFRSF10C Gene

      Publications for TNFRSF10C Gene

      1. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. (PMID: 9314565) Degli-Esposti M.A. … Smith C.A. (J. Exp. Med. 1997) 2 3 4 23
      2. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. (PMID: 9325248) MacFarlane M. … Alnemri E.S. (J. Biol. Chem. 1997) 2 3 4 23
      3. Characterization of two receptors for TRAIL. (PMID: 9373179) Schneider P. … Tschopp J. (FEBS Lett. 1997) 3 4 23
      4. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. (PMID: 9242610) Pan G. … Dixit V.M. (Science 1997) 3 4 23
      5. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. (PMID: 9242611) Sheridan J.P. … Ashkenazi A. (Science 1997) 3 4 23

      Products for TNFRSF10C Gene

      • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
      • Pathway & Disease-focused RT² Profiler PCR Arrays
        • TNF Ligands & Receptors in human,mouse,rat
      • QIAGEN qRT-PCR Assays for microRNAs that regulate TNFRSF10C
        • QuantiTect SYBR Green Assays in human,mouse,rat
        • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
        • QuantiFast Probe-based Assays in human,mouse,rat
        • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF10C
        • Block miRNA regulation of TNFRSF10C using miScript Target Protectors

        Sources for TNFRSF10C Gene

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