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Aliases for TNFRSF10B Gene

Aliases for TNFRSF10B Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 10b 2 3
  • TRAILR2 3 4 6
  • DR5 3 4 6
  • TNF-Related Apoptosis-Inducing Ligand Receptor 2 3 4
  • Death Receptor 5 3 4
  • TRAIL-R2 3 4
  • KILLER 3 4
  • TRICK2 3 4
  • ZTNFR9 3 4
  • P53-Regulated DNA Damage-Inducible Cell Death Receptor(Killer) 3
  • Tumor Necrosis Factor Receptor Superfamily Member 10B 3
  • Tumor Necrosis Factor Receptor-Like Protein ZTNFR9 3
  • Death Domain Containing Receptor For TRAIL/Apo-2L 3
  • Apoptosis Inducing Protein TRICK2A/2B 3
  • Apoptosis Inducing Receptor TRAIL-R2 3
  • TNF Receptor Superfamily Member 10b 3
  • Cytotoxic TRAIL Receptor-2 3
  • Fas-Like Protein 3
  • TRAIL Receptor 2 4
  • CD262 Antigen 4
  • KILLER/DR5 3
  • TRICK2A 3
  • TRICK2B 3
  • TRICKB 3
  • CD262 3

External Ids for TNFRSF10B Gene

Summaries for TNFRSF10B Gene

Entrez Gene Summary for TNFRSF10B Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for TNFRSF10B Gene

TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b) is a Protein Coding gene. Diseases associated with TNFRSF10B include squamous cell carcinoma, head and neck and oral cavity cancer. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include receptor activity and TRAIL binding. An important paralog of this gene is TNFRSF10D.

UniProtKB/Swiss-Prot for TNFRSF10B Gene

  • Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

Gene Wiki entry for TNFRSF10B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF10B Gene

Genomics for TNFRSF10B Gene

Genomic Location for TNFRSF10B Gene

23,020,133 bp from pter
23,069,187 bp from pter
49,055 bases
Minus strand

Genomic View for TNFRSF10B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF10B Gene

Regulatory Elements for TNFRSF10B Gene

Transcription factor binding sites by QIAGEN in the TNFRSF10B gene promoter:

Proteins for TNFRSF10B Gene

  • Protein details for TNFRSF10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 10B
    Protein Accession:
    Secondary Accessions:
    • O14720
    • O15508
    • O15517
    • O15531
    • Q6UXM8
    • Q7Z360
    • Q9BVE0

    Protein attributes for TNFRSF10B Gene

    440 amino acids
    Molecular mass:
    47878 Da
    Quaternary structure:
    • Homotrimer. Can interact with TRADD and RIPK1. Interacts with HCMV protein UL141; this interaction prevents TNFRSF10B cell surface expression. Two TNFRSF10B monomers interact with a UL141 homodimer.

    Three dimensional structures from OCA and Proteopedia for TNFRSF10B Gene

    Alternative splice isoforms for TNFRSF10B Gene


neXtProt entry for TNFRSF10B Gene

Proteomics data for TNFRSF10B Gene at MOPED

Post-translational modifications for TNFRSF10B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys245

Other Protein References for TNFRSF10B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFRSF10B Gene

Domains for TNFRSF10B Gene

Gene Families for TNFRSF10B Gene

  • CD :CD molecules
  • TNFRSF :Tumor necrosis factor receptor superfamily

Protein Domains for TNFRSF10B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 death domain.:
    • O14763
  • Contains 3 TNFR-Cys repeats.:
    • O14763
genes like me logo Genes that share domains with TNFRSF10B: view

Function for TNFRSF10B Gene

Molecular function for TNFRSF10B Gene

GENATLAS Biochemistry: tumor necrosis factor receptor superfamily,member 10B,expressed in the proliferating compartment of colonic crypt epithelia,TP53,inducible,binding APO2L,inducing a caspase-dependent apoptotic pathway,FADD dependent,inactivated in colorectal tumorigenesis (see TSG8A)
UniProtKB/Swiss-Prot Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
UniProtKB/Swiss-Prot Induction: By ER stress. Regulated by p53/TP53.

Gene Ontology (GO) - Molecular Function for TNFRSF10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity NAS 9311998
GO:0005515 protein binding IPI 10549288
GO:0045569 TRAIL binding NAS 9373179
genes like me logo Genes that share ontologies with TNFRSF10B: view
genes like me logo Genes that share phenotypes with TNFRSF10B: view

Animal Models for TNFRSF10B Gene

MGI Knock Outs for TNFRSF10B:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TNFRSF10B Gene

Localization for TNFRSF10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF10B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TNFRSF10B Gene COMPARTMENTS Subcellular localization image for TNFRSF10B gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 2
mitochondrion 2
cytosol 1
extracellular 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TNFRSF10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 22952982
GO:0016021 integral component of membrane IC 9311998
genes like me logo Genes that share ontologies with TNFRSF10B: view

Pathways for TNFRSF10B Gene

genes like me logo Genes that share pathways with TNFRSF10B: view

Gene Ontology (GO) - Biological Process for TNFRSF10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0007165 signal transduction --
GO:0007166 cell surface receptor signaling pathway TAS --
GO:0007250 activation of NF-kappaB-inducing kinase activity NAS 11464292
genes like me logo Genes that share ontologies with TNFRSF10B: view

Compounds for TNFRSF10B Gene

(1) IUPHAR Ligand for TNFRSF10B Gene

Ligand Type Action Affinity Pubmed IDs
TRAIL None None

(49) Novoseek inferred chemical compound relationships for TNFRSF10B Gene

Compound -log(P) Hits PubMed IDs
tri (d) 83.7 5
sulindac sulfide 66.5 11
mg 132 65.4 14
bortezomib 64.2 7
sp 600125 60.5 2
genes like me logo Genes that share compounds with TNFRSF10B: view

Transcripts for TNFRSF10B Gene

Unigene Clusters for TNFRSF10B Gene

Tumor necrosis factor receptor superfamily, member 10b:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF10B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP7: - - - - -
SP10: -

Relevant External Links for TNFRSF10B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF10B Gene

mRNA expression in normal human tissues for TNFRSF10B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNFRSF10B Gene

SOURCE GeneReport for Unigene cluster for TNFRSF10B Gene Hs.521456

mRNA Expression by UniProt/SwissProt for TNFRSF10B Gene

Tissue specificity: Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain
genes like me logo Genes that share expressions with TNFRSF10B: view

No data available for mRNA differential expression in normal tissues for TNFRSF10B Gene

Orthologs for TNFRSF10B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF10B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFRSF10B 35
  • 98.78 (n)
  • 97.56 (a)
  • 97 (a)
(Bos Taurus)
Mammalia -- 36
  • 46 (a)
-- 36
  • 41 (a)
  • 34 (a)
(Mus musculus)
Mammalia Tnfrsf10b 16
Tnfrsf10b 36
  • 32 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 27 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
(Gallus gallus)
Aves TNFRSF10B 35
  • 51.68 (n)
  • 38.76 (a)
TVB 36
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfrsf10b 35
  • 47.67 (n)
  • 39.78 (a)
(Danio rerio)
Actinopterygii hdr 36
  • 19 (a)
tnfrsfa 36
  • 18 (a)
Species with no ortholog for TNFRSF10B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF10B Gene

Gene Tree for TNFRSF10B (if available)
Gene Tree for TNFRSF10B (if available)

Paralogs for TNFRSF10B Gene

Paralogs for TNFRSF10B Gene

Selected SIMAP similar genes for TNFRSF10B Gene using alignment to 6 proteins: Pseudogenes for TNFRSF10B Gene

genes like me logo Genes that share paralogs with TNFRSF10B: view

Variants for TNFRSF10B Gene

Sequence variations from dbSNP and Humsavar for TNFRSF10B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs871787 -- 23,028,199(-) TCCTC(A/G)TGGTC intron-variant
rs883429 -- 23,029,305(+) CTACT(C/T)ATTCT intron-variant
rs1001791 -- 23,043,858(-) GTAAG(C/T)ACACT intron-variant
rs1001792 -- 23,043,689(-) TCCCA(A/G)TTTTT intron-variant
rs1001793 -- 23,043,436(-) TTGCA(A/G)GTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF10B Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
nsv524231 CNV Loss 19592680
esv2736750 CNV Deletion 23290073
esv1764616 CNV Deletion 17803354
esv2671855 CNV Deletion 23128226

Relevant External Links for TNFRSF10B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF10B Gene

Disorders for TNFRSF10B Gene

(1) OMIM Diseases for TNFRSF10B Gene (603612)


  • Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Note=The disease may be caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for TNFRSF10B Gene

(63) Novoseek inferred disease relationships for TNFRSF10B Gene

Disease -log(P) Hits PubMed IDs
necrosis 84.2 106
tumors 74.8 155
cancer 66.6 72
colon cancer 55.5 18
malignant glioma 54 5

Relevant External Links for TNFRSF10B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TNFRSF10B: view

Publications for TNFRSF10B Gene

  1. TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL. (PMID: 9285725) Screaton G.R. … Bell J.I. (Curr. Biol. 1997) 2 3 4 23
  2. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. (PMID: 9311998) Walczak H. … Rauch C.T. (EMBO J. 1997) 2 3 4 23
  3. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. (PMID: 9325248) MacFarlane M. … Alnemri E.S. (J. Biol. Chem. 1997) 3 4 23
  4. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. (PMID: 9430227) Chaudhary P.M. … Hood L. (Immunity 1997) 3 4 23
  5. Genetic variation in APOJ, LPL, and TNFRSF10B affects plasma fatty acid distribution in Alaskan Eskimos. (PMID: 20410100) Voruganti V.S. … Comuzzie A.G. (Am. J. Clin. Nutr. 2010) 3 23 48

Products for TNFRSF10B Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis in human,mouse,rat
    • Apoptosis 384HT in human,mouse,rat
    • Liver Cancer in human,mouse,rat
    • Molecular Toxicology PathwayFinder 384HT in human,mouse,rat
    • NFKB Signaling Pathway in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TNFRSF10B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF10B
  • Block miRNA regulation of TNFRSF10B using miScript Target Protectors

Sources for TNFRSF10B Gene

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