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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TNFRSF10B Gene

protein-coding GIFtS: 70
GCID: GC08M022877

tumor necrosis factor receptor superfamily, member 10b

Explore 98 diseases affiliated with
TNFRSF10B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 10b¹ ²		KILLER/DR5²
DR5¹ ² ³ ⁵		TRICK2B²
KILLER¹ ² ³		Apoptosis Inducing Protein TRICK2A/2B²
TRAIL-R2¹ ² ³		Apoptosis Inducing Receptor TRAIL-R2²
TRAILR2² ³ ⁵		Cytotoxic TRAIL Receptor-2²
CD262¹ ²		Death Domain Containing Receptor For TRAIL/Apo-2L²
TRICK2A¹ ²		Fas-Like Protein²
TRICKB¹ ²		P53-Regulated DNA Damage-Inducible Cell Death Receptor(Killer)²
Death Receptor 5² ³		Tumor Necrosis Factor Receptor Superfamily Member 10B²
TRICK2² ³		Tumor Necrosis Factor Receptor-Like Protein ZTNFR9²
ZTNFR9² ³		CD262 Antigen³
TNF-Related Apoptosis-Inducing Ligand Receptor 2² ³		TRAIL Receptor 2³

External Ids:	HGNC: 11905¹	Entrez Gene: 8795²	Ensembl: ENSG00000120889⁷	OMIM: 603612⁵	UniProtKB: O14763³

ORGUL members:
	NONCODE:n407670

Export aliases for TNFRSF10B gene to outside databases

Previous GC identifers: GC08M022647 GC08M023231 GC08M022899 GC08M022933 GC08M021422

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF10B:

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death

domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand

(TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a

death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript

variants encoding different isoforms and one non-coding transcript have been found for this gene. (provided by RefSeq,

Mar 2009)

UniProtKB/Swiss-Prot: TR10B_HUMAN, O14763

Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the

activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation

which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis

Gene Wiki entry for TNFRSF10B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNFRSF10B gene promoter:
c-Fos STAT1 AP-1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TNFRSF10B promoter sequence

Search SABiosciences Chromatin IP Primers for TNFRSF10B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF10B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22-p21 Ensembl cytogenetic band: 8p21.3 HGNC cytogenetic band: 8p22-p21

TNFRSF10B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF10B gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M022877: view genomic region (about GC identifiers)

Start:	22,877,646 bp from pter	End:	22,926,700 bp from pter
Size:	49,055 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TR10B_HUMAN, O14763 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 10B precursor

Size: 440 amino acids; 47878 Da

Subunit: Homotrimer. Can interact with TRADD and RIPK1

Subcellular location: Membrane; Single-pass type I membrane protein

5 PDB 3D structures from and Proteopedia for TNFRSF10B:

1D0G (3D)

1D4V (3D)

1DU3 (3D)

1ZA3 (3D)

2H9G (3D)

Secondary accessions: O14720 O15508 O15517 O15531 Q6UXM8 Q7Z360 Q9BVE0

Alternative splicing: 3 isoforms: O14763-1 O14763-3 O14763-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for TNFRSF10B: NX_O14763

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14763

TNFRSF10B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_003833.4 NP_671716.2

ENSEMBL proteins:

ENSP00000276431 ENSP00000317859 ENSP00000427999 ENSP00000443386

Reactome Protein details: O14763
Human Recombinant Protein Products:

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	Sino Biological Recombinant Protein for TNFRSF10B
	ProSpec Recombinant Protein for TNFRSF10B
	Uscn Proteins for TNFRSF10B

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IC	9311998

TNFRSF10B for ontologies About GeneDecksing

TNFRSF10B Antibody Products:

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	Novus Biologicals TNFRSF10B Antibodies
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	ThermoFisher Antibody for TNFRSF10B

Assay Products for TNFRSF10B:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for TNFRSF10B
	Enzo Life Sciences assays for TNFRSF10B
	Uscn ELISAs and CLIAs for TNFRSF10B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNFRSF10B for domains About GeneDecksing

4 InterPro domains/families:

IPR001368 TNFR/NGFR_Cys_rich_reg

IPR011029 DEATH-like_dom

IPR000488 Death_domain

IPR020465 TNFR_10

Graphical View of Domain Structure for InterPro Entry O14763

ProtoNet protein and cluster: O14763

1 Blocks protein family: IPB000488 Death domain

UniProtKB/Swiss-Prot: TR10B_HUMAN, O14763

Similarity: Contains 1 death domain

Similarity: Contains 3 TNFR-Cys repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TR10B_HUMAN, O14763

Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the

activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation

which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis

Induction: By ER stress. Regulated by p53/TP53

Genatlas biochemistry entry for TNFRSF10B:

tumor necrosis factor receptor superfamily,member 10B,expressed in the proliferating compartment of colonic crypt

epithelia,TP53,inducible,binding APO2L,inducing a caspase-dependent apoptotic pathway,FADD dependent,inactivated in

colorectal tumorigenesis (see TSG8A)

miRNA Products:		miRTarBase miRNAs that target TNFRSF10B: hsa-mir-30a (MIRT005122)

		OriGene 3'-UTR Clone (see all 2): TNFRSF10B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFRSF10B
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFRSF10B:
		hsa-miR-133a hsa-miR-133b hsa-miR-410 hsa-miR-1279
		SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF10B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFRSF10B (see all 7) OriGene shRNA RFP: TNFRSF10B OriGene siRNA: TNFRSF10B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFRSF10B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TNFRSF10B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): TNFRSF10B (NM_003842)
		Sino Biological Human cDNA Clone for TNFRSF10B
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TNFRSF10B
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF10B

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	NAS	9311998
GO:0005515	protein binding	IPI	--
GO:0045569	TRAIL binding	NAS	9373179

TNFRSF10B for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for TNFRSF10B: Tnfrsf10b^tm1.1Cjk Tnfrsf10b^tm1Wsed Tnfrsf10b^tm1Wnt
     7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Tnfrsf10b):

cellular	hematopoietic system	homeostasis/metabolism	immune system	mortality/aging
no phenotypic analysis	tumorigenesis

TNFRSF10B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Death Receptor Signalling

	Death Receptor Signalling	1.00			Dimerization of procaspase-8	0.75
	Extrinsic Pathway for Apoptosis	1.00			Caspase-8 activation	0.75

PEDF Induced Signaling

	STAT3 Pathway	0.47			Glucocorticoid Receptor Signaling	0.27
	PGC1Alpha Pathway	0.33			Cytokine-cytokine receptor interaction	0.26

TGF-Beta Pathway

	TGF-Beta Pathway	1.00			JNK Pathway	0.50
	JAK-STAT Pathway	0.57

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Apoptosis and survival_Apoptotic TNF-family pathways

	Apoptosis and survival_Apoptotic TNF-family pathways	1.00			Apoptosis Signaling Pathways	0.35
	Apoptosis and survival Apoptotic TNF-family pathways	1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TNFRSF10B

Apoptosis and survival Apoptotic TNF-family pathways

2 R&D Systems Pathways for TNFRSF10B

	TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
	Apoptosis Signaling Pathways

5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF10B (see all 17)

	STAT3 Pathway
	Molecular Mechanisms of Cancer
	TGF-Beta Pathway
	JAK-STAT Pathway
	Glucocorticoid Receptor Signaling

2 Cell Signaling Technology (CST) Pathways for TNFRSF10B

	Apoptosis and Autophagy
	NF-kappaB Signaling

1 GeneGo (Thomson Reuters) Pathway for TNFRSF10B

Apoptosis and survival Apoptotic TNF-family pathways

5 BioSystems Pathways for TNFRSF10B

	Apoptosis
	Apoptosis Modulation and Signaling
	DNA damage response
	Direct p53 effectors
	TRAIL signaling pathway

5/6 Reactome Pathways for TNFRSF10B (see all 6)

	Death Receptor Signalling
	Extrinsic Pathway for Apoptosis
	Caspase-8 activation
	TRAIL signaling
	Dimerization of procaspase-8

5/6 Kegg Pathways (Kegg details for TNFRSF10B) (see all 6):

	Cytokine-cytokine receptor interaction
	p53 signaling pathway
	Apoptosis
	Natural killer cell mediated cytotoxicity
	Measles

TNFRSF10B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TNFRSF10B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/33 Interacting proteins for TNFRSF10B (O14763^{1, 2, 3} ENSP00000276431⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 33)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TNFSF10	P50591¹^,²^,³, ENSP00000241261⁴	EBI-518882,EBI-495373 MINT-24897 I2D: score=7 STRING: ENSP00000241261
FADD	Q13158²^,³, ENSP00000301838⁴	MINT-17413 I2D: score=5 STRING: ENSP00000301838
CASP8	Q14790³, ENSP00000351273⁴	I2D: score=4 STRING: ENSP00000351273
TRADD	Q15628³, ENSP00000341268⁴	I2D: score=3 STRING: ENSP00000341268
TNFRSF10D	Q9UBN6³, ENSP00000310263⁴	I2D: score=2 STRING: ENSP00000310263

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	TAS	--
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	TAS	--
GO:0007165	signal transduction	--	--
GO:0007166	cell surface receptor signaling pathway	TAS	9311998
GO:0007250	activation of NF-kappaB-inducing kinase activity	NAS	9430227

TNFRSF10B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TNFRSF10B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNFRSF10B
10/49 Novoseek chemical compound relationships for TNFRSF10B gene (see all 49) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tri (d)	83.7	6	10811986 (3), 11162590 (1), 9973225 (1)
sulindac sulfide	66.5	12	12203115 (4), 11559570 (3), 16699947 (1), 15180942 (1) (see all 6)
mg 132	65.4	15	15994939 (9), 16287099 (3), 14691451 (2)
bortezomib	64.2	9	20126991 (2), 16699949 (1), 16098063 (1), 20442297 (1) (see all 6)
sp 600125	60.5	2	17145888 (1), 18341587 (1)
suberoylanilide hydroxamic acid	56.5	3	19737941 (2), 15208660 (1)
cd 437	56.2	5	11002424 (2), 16024638 (1), 11156424 (1)
adpribose	47.8	1	14520473 (1)
etoposide	46.5	13	11090076 (2), 15964798 (2), 10594023 (2), 12838325 (1) (see all 7)
doxorubicin	44.2	22	17922852 (4), 11090076 (2), 17649723 (2), 15897917 (1) (see all 12)

Search CenterWatch for drugs/clinical trials and news about TNFRSF10B / TR10B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNFRSF10B gene (2 alternative transcripts):

NM_003842.4 NM_147187.2

Unigene Cluster for TNFRSF10B:

Tumor necrosis factor receptor superfamily, member 10b

Hs.521456 [show with all ESTs]

Unigene Representative Sequence: NM_003842

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000523752(uc003xcs.1) ENST00000276431(uc003xct.2 uc011kzq.1 uc003xcu.2 uc003xcv.2)

ENST00000347739 ENST00000523504 ENST00000520109 ENST00000518531 ENST00000519910

ENST00000519028 ENST00000542226

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFRSF10B
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		hsa-miR-133a hsa-miR-133b hsa-miR-410 hsa-miR-1279
		SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF10B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF10B

Additional cDNA sequence:

AB451272.1 AB451399.1 AF012535.1 AF012628.1 AF016266.1 AF016268.1 AF016849.1 AF018657.1

AF018658.1 AF020501.1 AF022386.1 AF153687.1 AF192548.1 AK291216.1 AK296128.1 AK298602.1

AY358277.1 BC001281.1 BX537617.1 BX538179.1 CR541898.1 NR_027140.1

22 DOTS entries:

DT.95308015 DT.92460567 DT.100797527 DT.95308039 DT.101985073 DT.100649285 DT.121466262 DT.312740

DT.121466281 DT.95308049 DT.100797524 DT.121466183 DT.100037335 DT.100711561 DT.100797522 DT.100797529

DT.121466101 DT.121466151 DT.121466263 DT.95181465 DT.99944989 DT.100797525

24/323 AceView cDNA sequences (see all 323):

BX537617 BQ919940 BU552539 BF792478 BU169599 AI638131 BQ430360 BM740956

AA769631 NM_003842 BQ228766 CR593628 BX538179 AW151224 BE744315 BM823241

AF012628 AW089794 BG574421 AI587622 BU157103 AA157415 BQ647355 AA232424

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF10B (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·	11b	·	11c	·	11d
SP1:											-						-														-		-				-
SP2:											-						-														-		-				-
SP3:											-		-		-		-
SP4:											-						-				-
SP5:																																					-

ECgene alternative splicing isoforms for TNFRSF10B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNFRSF10B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCAAATTAA

About this image
See TNFRSF10B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFRSF10B

SOURCE GeneReport for Unigene cluster: Hs.521456

UniProtKB/Swiss-Prot: TR10B_HUMAN, O14763

Tissue specificity: Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as

HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver,

pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal

tract; not detectable in brain

SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF10B (see all 9):

Liver Cancer in human mouse rat

Apoptosis in human mouse rat

Stress & Toxicity PathwayFinder in human mouse rat

p53 Signaling Pathway in human mouse rat

NFKB Signaling Pathway in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF10B gene from 3/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TNFRSF10B¹	tumor necrosis factor receptor superfamily, member more	50.19(n) 38(a)		373904 NM_204115.2 NP_989446.2
lizard (Anolis carolinensis)	Reptilia	--	--	27(a)	1 → many	GL343679.1(101366-110435)
zebrafish (Danio rerio)	Actinopterygii	tnfrsfa⁶ hdr⁶	hematopoietic death receptor	18(a) 18(a)	many ↔ many many ↔ many	21(14375999-14422468) 5(29049495-29059630)

ENSEMBL Gene Tree for TNFRSF10B (if available)
TreeFam Gene Tree for TNFRSF10B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TNFRSF10B gene

TNFRSF10C² FAS² TNFRSF10A² TNFRSF10D²

5 SIMAP similar genes for TNFRSF10B using alignment to 6 protein entries: TR10B_HUMAN (see all proteins):

DKFZp686A24188 DR5 TNFRSF10C TNFRSF10A TNFRSF10D

TNFRSF10B for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for TNFRSF10B
PGOHUM00000249593

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138230177^1,2	C,	--	21421653(-)	`CTCTGC/ACCCGG`	3	--	ds500¹		1		NS	378
rs76699064^1,2	F,	--	21421767(+)	`TCCCCG/AAGAGC`	3	--	ds500¹		1		WA	118
rs41308108^1,2	C,F,	--	21421777(+)	`CTGTCG/AGAACC`	3	--	ds500¹		5		WA NA NS	606
rs138809331^1,2	C,	--	21421792(-)	`TGCCGG/AGTTGC`	3	--	ds500¹		1		NS	364
rs144933855^1,2	F	--	21421814(-)	`CTCCC-/CAGGAG`	3	--	ds500¹		1		NS	364
rs3187321^1,2	C	--	21422223(-)	`TGCTTC/TTGCCC`	3	--	ut3¹ nc-transcript-variantese³		3		MN NA	188
rs28441503^1,2		--	21422456(+)	`GGAGTA/TCGAGA`	3	--	ut3¹ nc-transcript-variantese³		1		CSA	1
rs60740128^1,2	C,	--	21422514(+)	`AATTAG/ACCAGG`	3	--	ut3¹ nc-transcript-variant		1		WA	2
rs75721284^1,2		--	21423308(+)	`ACCCTA/GAAAGG`	3	--	nc-transcript-variantut3¹		1		WA	118
rs11991499^1,2	H	--	21424063(+)	`atctaA/Gacaaa`	3	--	ut3¹ nc-transcript-variantese³		0	--	--	--	--

HapMap Linkage Disequilibrium report for TNFRSF10B (22877646 - 22926700 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TNFRSF10B
1 CNV: 3726
Human Gene Mutation Database (HGMD): TNFRSF10B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TNFRSF10B for disorders           About GeneDecksing

OMIM gene information: 603612
OMIM disorders: 275355
UniProtKB/Swiss-Prot: TR10B_HUMAN, O14763

Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known

as squamous cell carcinoma of the head and neck

20/98 diseases for TNFRSF10B (see all 98): About MalaCards

diffuse large b-cell lymphoma familial adenomatous polyposis amyotrophic lateral sclerosis b-cell lymphomas

squamous cell carcinoma of the head and neck non-hodgkin lymphoma squamous cell carcinoma soft tissue sarcoma

lateral sclerosis oral cavity cancer renal cell carcinoma malignant mesothelioma

primary effusion lymphoma burkitt's lymphoma leukemia/lymphoma myeloid leukemia

malignant glioma mantle cell lymphoma esophageal squamous cell carcinoma leukemia/lymphoma, t-cell

1 disease from the University of Copenhagen DISEASES database for TNFRSF10B:

Cancer

10/63 Novoseek disease relationships for TNFRSF10B gene (see all 63) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	84.2	213	11559570 (3), 12208739 (2), 18164688 (2), 10807904 (2) (see all 99)
tumors	74.8	352	15555281 (5), 11205299 (4), 18457325 (4), 15897419 (3) (see all 99)
cancer	66.6	96	16007131 (2), 17661715 (2), 15911244 (2), 17922852 (2) (see all 61)
colon cancer	55.5	20	18852146 (3), 12208739 (2), 19637313 (2), 17638911 (2) (see all 13)
malignant glioma	54	5	16033134 (2), 19939880 (2), 17367063 (1)
glioma	47.5	28	15844877 (5), 19079141 (2), 14973547 (2), 11784850 (2) (see all 13)
cancer lung	44.3	36	17172826 (3), 17145853 (2), 11802207 (2), 11205299 (2) (see all 19)
head cancer	42.2	1	12175536 (1)
carcinoma renal cell	42	8	18544564 (2), 16391797 (2), 17184908 (1), 18304965 (1) (see all 6)
nsclc	40	48	11205299 (9), 18457325 (4), 17510429 (4), 10582684 (2) (see all 10)

Genetic Association Database (GAD): TNFRSF10B
Human Genome Epidemiology (HuGE) Navigator: TNFRSF10B (19 documents)

Export disorders for TNFRSF10B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TNFRSF10B gene, integrated from 9 sources (see all 683):
(articles sorted by number of sources associating them with TNFRSF10B)

Utopia: connect your pdf to the dynamic
world of online information

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. (PubMed id 9311998)^{1, 2, 3, 9} Walczak H.... Rauch C.T. (1997)
TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL. (PubMed id 9285725)^{1, 2, 3, 9} Screaton G.R.... Bell J.I. (1997)
Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. (PubMed id 9430227)^{1, 2, 9} Chaudhary P.M.... Hood L. (1997)
Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. (PubMed id 9325248)^{1, 2, 9} MacFarlane M.... Alnemri E.S. (1997)
Characterization of two receptors for TRAIL. (PubMed id 9373179)^{1, 2, 9} Schneider P....Tschopp J. (1997)
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. (PubMed id 15322075)^{1, 2} Yamaguchi H. and Wang H.G. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{1, 2} Hillman R.T.... Brenner S.E. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. (PubMed id 10549288)^{1, 2} Hymowitz S.G.... de Vos A.M. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8795	HGNC: 11905	AceView: TNFRSF10B	Ensembl:ENSG00000120889	euGenes: HUgn8795
ECgene: TNFRSF10B	Kegg: 8795	H-InvDB: TNFRSF10B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TNFRSF10B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFRSF10B	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TNFRSF10B gene
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Patent Information for TNFRSF10B gene:
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GeneCards and IP:
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TNFRSF10B Gene

tumor necrosis factor receptor superfamily, member 10b

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TNFRSF10B (Gene Symbol)
Tumor Necrosis Factor Receptor Superfamily, Member 10b
DR5
KILLER
TRAIL-R2
TRAILR2
CD262
TRICK2A
TRICKB
Death Receptor 5
TRICK2
ZTNFR9
TNF-Related Apoptosis-Inducing Ligand Receptor 2
KILLER/DR5
TRICK2B
Apoptosis Inducing Protein TRICK2A/2B
Apoptosis Inducing Receptor TRAIL-R2
Cytotoxic TRAIL Receptor-2
Death Domain Containing Receptor For TRAIL/Apo-2L
Fas-Like Protein
P53-Regulated DNA Damage-Inducible Cell Death Receptor(Killer)
Tumor Necrosis Factor Receptor Superfamily Member 10B
Tumor Necrosis Factor Receptor-Like Protein ZTNFR9
CD262 Antigen
TRAIL Receptor 2

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TNFRSF10B Gene

tumor necrosis factor receptor superfamily, member 10b

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