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TNFRSF10B Gene

protein-coding   GIFtS: 72
GCID: GC08M022877

Tumor Necrosis Factor Receptor Superfamily, Member 10b

  See TNFRSF10B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 10b1 2     TRICKB2
DR52 3 5     Apoptosis Inducing Protein TRICK2A/2B2
TRAILR22 3 5     Apoptosis Inducing Receptor TRAIL-R22
Death Receptor 52 3     Cytotoxic TRAIL Receptor-22
KILLER2 3     Death Domain Containing Receptor For TRAIL/Apo-2L2
TRAIL-R22 3     Fas-Like Protein2
TRICK22 3     P53-Regulated DNA Damage-Inducible Cell Death Receptor(Killer)2
ZTNFR92 3     TNF Receptor Superfamily Member 10b2
TNF-Related Apoptosis-Inducing Ligand Receptor 22 3     Tumor Necrosis Factor Receptor Superfamily Member 10B2
CD2622     Tumor Necrosis Factor Receptor-Like Protein ZTNFR92
KILLER/DR52     CD262 Antigen3
TRICK2A2     TRAIL Receptor 23
TRICK2B2     

External Ids:    HGNC: 119051   Entrez Gene: 87952   Ensembl: ENSG000001208897   OMIM: 6036125   UniProtKB: O147633   

Export aliases for TNFRSF10B gene to outside databases

Previous GC identifers: GC08M022647 GC08M023231 GC08M022899 GC08M022933 GC08M021422


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFRSF10B Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death
domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand
(TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD,
a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript
variants encoding different isoforms and one non-coding transcript have been found for this gene. (provided by
RefSeq, Mar 2009)

GeneCards Summary for TNFRSF10B Gene:
TNFRSF10B (tumor necrosis factor receptor superfamily, member 10b) is a protein-coding gene. Diseases associated with TNFRSF10B include squamous cell carcinoma of the head and neck, and oral cavity cancer. GO annotations related to this gene include TRAIL binding and receptor activity. An important paralog of this gene is TNFRSF10C.

UniProtKB/Swiss-Prot: TR10B_HUMAN, O14763
Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the
activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic
activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating
apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis

Gene Wiki entry for TNFRSF10B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFRSF10B gene promoter:
         c-Fos   STAT1   AP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TNFRSF10B promoter sequence
   Search Chromatin IP Primers for TNFRSF10B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF10B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22-p21   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p22-p21

TNFRSF10B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF10B gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M022877:  view genomic region     (about GC identifiers)

Start:
22,877,646 bp from pter      End:
22,926,700 bp from pter
Size:
49,055 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TR10B_HUMAN, O14763 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 10B precursor  
Size: 440 amino acids; 47878 Da
Subunit: Homotrimer. Can interact with TRADD and RIPK1
6 PDB 3D structures from and Proteopedia for TNFRSF10B:
1D0G (3D)        1D4V (3D)        1DU3 (3D)        1ZA3 (3D)        2H9G (3D)        4I9X (3D)    
Secondary accessions: O14720 O15508 O15517 O15531 Q6UXM8 Q7Z360 Q9BVE0
Alternative splicing: 3 isoforms:  O14763-1   O14763-3   O14763-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for TNFRSF10B: NX_O14763

Explore proteomics data for TNFRSF10B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys245
  • Modification sites at PhosphoSitePlus

  • See TNFRSF10B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003833.4  NP_671716.2  

    ENSEMBL proteins: 
     ENSP00000276431   ENSP00000317859   ENSP00000427999   ENSP00000443386  
    Reactome Protein details: O14763

    TNFRSF10B Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TNFRSF10B
    OriGene MassSpec for TNFRSF10B
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    GenScript Purified and Recombinant Proteins for TNFRSF10B
    Novus Biologicals TNFRSF10B Proteins
    Novus Biologicals TNFRSF10B Lysates
    Sino Biological Recombinant Protein for TNFRSF10B
    Sino Biological Cell Lysate for TNFRSF10B
    ProSpec Recombinant Protein for TNFRSF10B
    Cloud-Clone Corp. Proteins for TNFRSF10B

     
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    TNFRSF10B Antibody Products:

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    R&D Systems Antibodies for TNFRSF10B (TRAIL R2/TNFRSF10B)
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    Novus Biologicals TNFRSF10B Antibodies
    Abcam antibodies for TNFRSF10B
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    ThermoFisher Antibody for TNFRSF10B
    LSBio Antibodies in human, mouse, rat for TNFRSF10B

    TNFRSF10B Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Luminex Assays for TNFRSF10B (TRAIL R2/TNFRSF10B)         (see all)
    GenScript Custom Assay Services for TNFRSF10B
    Enzo Life Sciences assays for TNFRSF10B
    Cloud-Clone Corp. ELISAs for TNFRSF10B
    Cloud-Clone Corp. CLIAs for TNFRSF10B
    Search eBioscience for ELISAs for TNFRSF10B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: death receptor 5
    Tumour necrosis factor (TNF) receptor family

    4 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR011029 DEATH-like_dom
     IPR000488 Death_domain
     IPR020465 TNFR_10

    Graphical View of Domain Structure for InterPro Entry O14763

    ProtoNet protein and cluster: O14763

    1 Blocks protein domain: IPB000488 Death domain

    UniProtKB/Swiss-Prot: TR10B_HUMAN, O14763
    Similarity: Contains 1 death domain
    Similarity: Contains 3 TNFR-Cys repeats


    Find genes that share domains with TNFRSF10B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TR10B_HUMAN, O14763
    Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the
    activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic
    activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating
    apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis
    Induction: By ER stress. Regulated by p53/TP53

         Genatlas biochemistry entry for TNFRSF10B:
    tumor necrosis factor receptor superfamily,member 10B,expressed in the proliferating compartment of colonic crypt
    epithelia,TP53,inducible,binding APO2L,inducing a caspase-dependent apoptotic pathway,FADD dependent,inactivated
    in colorectal tumorigenesis (see TSG8A)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity NAS9311998
    GO:0005515protein binding IPI10549288
    GO:0045569TRAIL binding NAS9373179
         
    Find genes that share ontologies with TNFRSF10B           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tnfrsf10b):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     no phenotypic analysis  tumorigenesis 

    Find genes that share phenotypes with TNFRSF10B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TNFRSF10B: Tnfrsf10btm1.1Cjk Tnfrsf10btm1Wsed Tnfrsf10btm1Wnt

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFRSF10B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF10B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF10B

    miRNA
    Products:
        
    miRTarBase miRNAs that target TNFRSF10B:
    hsa-mir-17-5p (MIRT050973), hsa-mir-92a-3p (MIRT049847), hsa-mir-331-3p (MIRT043345), hsa-mir-940 (MIRT036627), hsa-mir-30a-5p (MIRT005122), hsa-mir-340-5p (MIRT019597)

    Block miRNA regulation of human, mouse, rat TNFRSF10B using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TNFRSF10B:
    hsa-miR-133a hsa-miR-133b hsa-miR-410 hsa-miR-1279
    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF10B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF10B

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for TNFRSF10B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TNFRSF10B (NM_003842)
    Sino Biological Human cDNA Clone for TNFRSF10B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF10B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF10B
    Addgene plasmids for TNFRSF10B 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF10B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TR10B_HUMAN, O14763: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum2
    mitochondrion2
    cytosol1
    extracellular1
    lysosome1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IC9311998

    Find genes that share ontologies with TNFRSF10B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFRSF10B About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    PGC1Alpha Pathway0.51
    Glucocorticoid Receptor Signaling0.43
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41
    4p53 Signaling
    p53 Signaling0.38
    p53 Pathway0.38
    5Apoptosis Signaling Pathways
    Apoptosis and survival Apoptotic TNF family pathways0.35
    Apoptosis Signaling Pathways0.35


    Find genes that share SuperPaths with TNFRSF10B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for TNFRSF10B
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF10B (see all 17)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    TGF-Beta Pathway
    JAK-STAT Pathway
    Glucocorticoid Receptor Signaling

    2 Cell Signaling Technology (CST) Pathways for TNFRSF10B
        Apoptosis and Autophagy
    NF-kappaB Signaling

    1 GeneGo (Thomson Reuters) Pathway for TNFRSF10B
        Apoptosis and survival Apoptotic TNF-family pathways

    5 BioSystems Pathways for TNFRSF10B
        Apoptosis
    DNA damage response
    Apoptosis Modulation and Signaling
    TRAIL signaling pathway
    Direct p53 effectors

    4 Sino Biological Pathways for TNFRSF10B
        TNF Signaling
    p53 Pathway
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    4 Reactome Pathways for TNFRSF10B
        Caspase-8 activation
    TRAIL signaling
    Regulation by c-FLIP
    Dimerization of procaspase-8


    Selected Kegg Pathways  (Kegg details for TNFRSF10B) (see all 6):
        Cytokine-cytokine receptor interaction
    p53 signaling pathway
    Apoptosis
    Natural killer cell mediated cytotoxicity
    Measles

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF10B (see all 9): 
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              p53 Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFRSF10B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNFRSF10B (O147631, 2, 3 ENSP000002764314) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFSF10P505911, 2, 3, ENSP000002412614EBI-518882,EBI-495373 MINT-24897 I2D: score=7 STRING: ENSP00000241261
    FADDQ131582, 3, ENSP000003018384MINT-17413 I2D: score=5 STRING: ENSP00000301838
    CASP8Q147903, ENSP000003512734I2D: score=4 STRING: ENSP00000351273
    TRADDQ156283, ENSP000003412684I2D: score=3 STRING: ENSP00000341268
    TNFRSF10DQ9UBN63, ENSP000003102634I2D: score=2 STRING: ENSP00000310263
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process TAS--
    GO:0007165signal transduction ----
    GO:0007166cell surface receptor signaling pathway TAS9311998
    GO:0007250activation of NF-kappaB-inducing kinase activity NAS11464292

    Find genes that share ontologies with TNFRSF10B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFRSF10B (TR10B)

    1 IUPHAR Ligand for TNFRSF10B (death receptor 5)    About this table
    LigandTypeActionAffinityPubmed IDs
    TRAIL
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for TNFRSF10B gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tri (d) 83.7 6 10811986 (3), 11162590 (1), 9973225 (1)
    sulindac sulfide 66.5 12 12203115 (4), 11559570 (3), 16699947 (1), 15180942 (1) (see all 6)
    mg 132 65.4 15 15994939 (9), 16287099 (3), 14691451 (2)
    bortezomib 64.2 9 20126991 (2), 16699949 (1), 16098063 (1), 20442297 (1) (see all 6)
    sp 600125 60.5 2 17145888 (1), 18341587 (1)
    suberoylanilide hydroxamic acid 56.5 3 19737941 (2), 15208660 (1)
    cd 437 56.2 5 11002424 (2), 16024638 (1), 11156424 (1)
    adpribose 47.8 1 14520473 (1)
    etoposide 46.5 13 11090076 (2), 15964798 (2), 10594023 (2), 12838325 (1) (see all 7)
    doxorubicin 44.2 22 17922852 (4), 11090076 (2), 17649723 (2), 15897917 (1) (see all 12)



    Find genes that share compounds with TNFRSF10B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNFRSF10B gene (2 alternative transcripts): 
    NM_003842.4  NM_147187.2  

    Unigene Cluster for TNFRSF10B:

    Tumor necrosis factor receptor superfamily, member 10b
    Hs.521456  [show with all ESTs]
    Unigene Representative Sequence: NM_003842
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523752(uc003xcs.1) ENST00000276431(uc003xct.2 uc011kzq.1 uc003xcu.2 uc003xcv.2)
    ENST00000347739 ENST00000523504 ENST00000520109 ENST00000518531 ENST00000519910
    ENST00000519028 ENST00000542226
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate TNFRSF10B:
    hsa-miR-133a hsa-miR-133b hsa-miR-410 hsa-miR-1279
    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF10B 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): TNFRSF10B (NM_003842)
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    Addgene plasmids for TNFRSF10B 
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      QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF10B
      QuantiFast Probe-based Assays in human, mouse, rat TNFRSF10B

    Additional mRNA sequence: 

    AB451272.1 AB451399.1 AF012535.1 AF012628.1 AF016266.1 AF016268.1 AF016849.1 AF018657.1 
    AF018658.1 AF020501.1 AF022386.1 AF153687.1 AF192548.1 AK291216.1 AK296128.1 AK298602.1 
    AY358277.1 BC001281.1 BX537617.1 BX538179.1 CR541898.1 FJ200482.1 NR_027140.1 

    22 DOTS entries:

    DT.95308015  DT.92460567  DT.100797527  DT.95308039  DT.101985073  DT.100649285  DT.121466262  DT.312740 
    DT.121466281  DT.95308049  DT.100797524  DT.121466183  DT.100037335  DT.100711561  DT.100797522  DT.100797529 
    DT.121466101  DT.121466151  DT.121466263  DT.95181465  DT.99944989  DT.100797525 

    Selected AceView cDNA sequences (see all 323):

    BU157103 AW089794 BG574421 BX538179 BM765635 BQ712163 AW009147 BQ641531 
    AA157415 AL043674 CR593628 AI638131 BM773415 BM831047 BU169599 AF022386 
    BE744315 BQ651516 AA464535 AI559663 BQ430360 AW151224 CF127527 AI889863 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF10B (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d
    SP1:                                -                 -                                         -     -           -                                       
    SP2:                                -                 -                                         -     -           -                                       
    SP3:                                -     -     -     -                                                                                                   
    SP4:                                -                 -           -                                                                                       
    SP5:                                                                                                              -                                       


    ECgene alternative splicing isoforms for TNFRSF10B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFRSF10B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCAAATTAA
    TNFRSF10B Expression
    About this image


    TNFRSF10B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Granulocytes Peripheral Blood
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Retina
    TNFRSF10B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFRSF10B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.521456

    UniProtKB/Swiss-Prot: TR10B_HUMAN, O14763
    Tissue specificity: Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as
    HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver,
    pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the
    intestinal tract; not detectable in brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF10B (see all 9): 
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              p53 Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF10B gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf10b5 tumor necrosis factor receptor superfamily, member more   --   14 (36.10 cM) 69767472 
    chicken
    (Gallus gallus)
    Aves TNFRSF10B1 tumor necrosis factor receptor superfamily, member more 51.68(n)
    38.76(a)
      373904  NM_204115.2  NP_989446.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    27(a)
    1 → many
    GL343679.1(101366-110435)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tnfrsf10b1 tumor necrosis factor receptor superfamily, member more 47.67(n)
    39.78(a)
      448240  NM_001004894.1  NP_001004894.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hdr6
    tnfrsfa6
    hematopoietic death receptor
    tumor necrosis factor receptor superfamily, member...
    19(a)
    18(a)
    many ↔ many
    many ↔ many
    5(29049495-29059630) ENSDARG00000004392
    21(14375999-14422468) ENSDARG00000004451


    ENSEMBL Gene Tree for TNFRSF10B (if available)
    TreeFam Gene Tree for TNFRSF10B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNFRSF10B gene
    TNFRSF10C2  TNFRSF10A2  TNFRSF10D2  
    5 SIMAP similar genes for TNFRSF10B using alignment to 6 protein entries:     TR10B_HUMAN (see all proteins):
    DKFZp686A24188    DR5    TNFRSF10C    TNFRSF10A    TNFRSF10D

    Find genes that share paralogs with TNFRSF10B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TNFRSF10B
    PGOHUM00000249593


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFRSF10B (see all 1341)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2013002091,2
    C--21442996(+) TTTTT-/TTGTTGTT 3 -- int10--------
    rs339711911,2
    C--21442998(+) TTTTT-/GTTGTT 3 -- int10--------
    rs595839731,2
    C--21443000(+) TTGTT-/GTTTTTT 3 -- int11Minor allele frequency- GT:0.00NA 2
    rs754481331,2
    C--21452224(+) ATTTG-/TTTTGT 3 -- int10--------
    rs1134131551,2
    C--21460427(+) TTGGCT/-TTTTT 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs1382127111,2
    C--21461450(+) TTGTT-/TTTG  
            
    TTTGT
    3 -- int10--------
    rs2015285881,2
    C--21461617(+) TTTTT-/GTATTT 3 -- int10--------
    rs1139041981,2
    C--21461620(+) TTGTA-/TTTTTT 3 -- int11Minor allele frequency- T:0.00CSA 2
    rs354102891,2
    C--22880706(+) GAGTC-/AAAGTCG 3 -- int10--------
    rs577858291,2
    C--22883779(+) TTTTT-/TGTTTG 3 -- int10--------

    HapMap Linkage Disequilibrium report for TNFRSF10B (22877646 - 22926700 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TNFRSF10B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1764616CNV Deletion17803354
    esv2671855CNV Deletion23128226
    esv2736750CNV Deletion23290073
    nsv524231CNV Loss19592680
    essv19243CNV CNV17122850

    Human Gene Mutation Database (HGMD): TNFRSF10B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFRSF10B
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFRSF10B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 603612   
    OMIM disorders: 275355  
    UniProtKB/Swiss-Prot: TR10B_HUMAN, O14763
  • Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting
    the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
    Note=The disease may be caused by mutations affecting the gene represented in this entry

  • 4 diseases for TNFRSF10B:    
    About MalaCards
    squamous cell carcinoma of the head and neck    oral cavity cancer    pancreatic cancer    amyotrophic lateral sclerosis

    1 disease from the University of Copenhagen DISEASES database for TNFRSF10B:
    Cancer

    Find genes that share disorders with TNFRSF10B           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TNFRSF10B gene (see all 63)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 84.2 213 11559570 (3), 12208739 (2), 18164688 (2), 10807904 (2) (see all 99)
    tumors 74.8 352 15555281 (5), 11205299 (4), 18457325 (4), 15897419 (3) (see all 99)
    cancer 66.6 96 16007131 (2), 17661715 (2), 15911244 (2), 17922852 (2) (see all 61)
    colon cancer 55.5 20 18852146 (3), 12208739 (2), 19637313 (2), 17638911 (2) (see all 13)
    malignant glioma 54 5 16033134 (2), 19939880 (2), 17367063 (1)
    glioma 47.5 28 15844877 (5), 19079141 (2), 14973547 (2), 11784850 (2) (see all 13)
    cancer lung 44.3 36 17172826 (3), 17145853 (2), 11802207 (2), 11205299 (2) (see all 19)
    head cancer 42.2 1 12175536 (1)
    carcinoma renal cell 42 8 18544564 (2), 16391797 (2), 17184908 (1), 18304965 (1) (see all 6)
    nsclc 40 48 11205299 (9), 18457325 (4), 17510429 (4), 10582684 (2) (see all 10)

    Genetic Association Database (GAD): TNFRSF10B
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF10B (19 documents)

    Export disorders for TNFRSF10B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TNFRSF10B gene, integrated from 10 sources (see all 715):
    (articles sorted by number of sources associating them with TNFRSF10B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. (PubMed id 9311998)1, 2, 3, 9 Walczak H.... Rauch C.T. (EMBO J. 1997)
    2. TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL. (PubMed id 9285725)1, 2, 3, 9 Screaton G.R.... Bell J.I. (Curr. Biol. 1997)
    3. Genetic variation in APOJ, LPL, and TNFRSF10B affects plasma fatty acid distribution in Alaskan Eskimos. (PubMed id 20410100)1, 4, 9 Voruganti V.S....Comuzzie A.G. (Am. J. Clin. Nutr. 2010)
    4. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. (PubMed id 9430227)1, 2, 9 Chaudhary P.M.... Hood L. (Immunity 1997)
    5. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. (PubMed id 9325248)1, 2, 9 MacFarlane M.... Alnemri E.S. (J. Biol. Chem. 1997)
    6. Characterization of two receptors for TRAIL. (PubMed id 9373179)1, 2, 9 Schneider P....Tschopp J. (FEBS Lett. 1997)
    7. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    8. Mutational analysis of death receptor genes Fas, TRAILR1 and TRAILR2 in prostate carcinomas. (PubMed id 20666744)1, 4 Park S.W....Lee S.H. (APMIS 2010)
    9. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    10. TNF superfamily gene polymorphism as prognostic factor in early breast cancer. (PubMed id 19890662)1, 4 Jung J.H....Park H.Y. (J. Cancer Res. Clin. Oncol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8795 HGNC: 11905 AceView: TNFRSF10B Ensembl:ENSG00000120889 euGenes: HUgn8795
    ECgene: TNFRSF10B Kegg: 8795 H-InvDB: TNFRSF10B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TNFRSF10B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF10B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFRSF10B gene:
    Search GeneIP for patents involving TNFRSF10B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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