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TNFRSF10A Gene

protein-coding   GIFtS: 68
GCID: GC08M023048

Tumor Necrosis Factor Receptor Superfamily, Member 10a

  See TNFRSF10A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 10a1 2     TRAIL Receptor 12 3
APO22 3 5     CD2612
DR42 3 5     TRAILR-12
TRAILR12 3 5     Cytotoxic TRAIL Receptor2
Death Receptor 42 3     Tumor Necrosis Factor Receptor Superfamily Member 10A2
TRAIL-R12 3     Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 22
TNF-Related Apoptosis-Inducing Ligand Receptor 12 3     CD261 Antigen3

External Ids:    HGNC: 119041   Entrez Gene: 87972   Ensembl: ENSG000001046897   OMIM: 6036115   UniProtKB: O002203   

Export aliases for TNFRSF10A gene to outside databases

Previous GC identifers: GC08M022787 GC08M023403 GC08M023070 GC08M023104 GC08M021594


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFRSF10A Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor
necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and
induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor
protein, is required for the apoptosis mediated by this protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFRSF10A Gene:
TNFRSF10A (tumor necrosis factor receptor superfamily, member 10a) is a protein-coding gene. Diseases associated with TNFRSF10A include post-transplant lymphoproliferative disease, and colon cancer. GO annotations related to this gene include TRAIL binding and transcription factor binding. An important paralog of this gene is TNFRSF10B.

UniProtKB/Swiss-Prot: TR10A_HUMAN, O00220
Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the
activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic
activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating
apoptosis. Promotes the activation of NF-kappa-B

Gene Wiki entry for TNFRSF10A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFRSF10A gene promoter:
         STAT1   Sp1   ATF-2   MyoD   c-Jun   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFRSF10A promoter sequence
   Search Chromatin IP Primers for TNFRSF10A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF10A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21

TNFRSF10A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF10A gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M023048:  view genomic region     (about GC identifiers)

Start:
23,047,965 bp from pter      End:
23,082,680 bp from pter
Size:
34,716 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TR10A_HUMAN, O00220 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 10A precursor  
Size: 468 amino acids; 50089 Da
Subunit: Can interact with TRADD and RIPK1. Interacts with ARAP1
Secondary accessions: A8K5I4 Q53Y72 Q96E62

Explore the universe of human proteins at neXtProt for TNFRSF10A: NX_O00220

Explore proteomics data for TNFRSF10A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn156
  • Modification sites at PhosphoSitePlus

  • See TNFRSF10A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003835.3  
    ENSEMBL proteins: 
     ENSP00000221132   ENSP00000428884  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: death receptor 4
    Tumour necrosis factor (TNF) receptor family

    4 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR011029 DEATH-like_dom
     IPR000488 Death_domain
     IPR020465 TNFR_10

    Graphical View of Domain Structure for InterPro Entry O00220

    ProtoNet protein and cluster: O00220

    2 Blocks protein domains:
    IPB000488 Death domain
    IPB001368 TNFR/CD27/30/40/95 cysteine-rich region


    UniProtKB/Swiss-Prot: TR10A_HUMAN, O00220
    Similarity: Contains 1 death domain
    Similarity: Contains 3 TNFR-Cys repeats


    Find genes that share domains with TNFRSF10A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TR10A_HUMAN, O00220
    Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the
    activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic
    activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating
    apoptosis. Promotes the activation of NF-kappa-B

         Genatlas biochemistry entry for TNFRSF10A:
    tumor necrosis factor receptor superfamily,member 10A,widely expressed,TNF related,widely expressed,apoptosis
    induced ligand (TRAIL) receptor 1,TP53 inducible,binding APO2L,inducing a caspase-dependent apoptotic
    pathway,FADD independent

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity NAS9311998
    GO:0005035death receptor activity TAS9082980
    GO:0005515protein binding IPI17047155
    GO:0008134transcription factor binding IPI18165900
    GO:0045569TRAIL binding NAS9373179
         
    Find genes that share ontologies with TNFRSF10A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TNFRSF10A:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFRSF10A
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TR10A_HUMAN, O00220: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    mitochondrion2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IC9311998

    Find genes that share ontologies with TNFRSF10A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFRSF10A About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    PGC1Alpha Pathway0.51
    Glucocorticoid Receptor Signaling0.43
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3Apoptosis Signaling Pathways
    Apoptosis and survival Apoptotic TNF family pathways0.35
    Apoptosis Signaling Pathways0.35
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    JAK-STAT Pathway0.57


    Find genes that share SuperPaths with TNFRSF10A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for TNFRSF10A
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF10A (see all 16)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    TGF-Beta Pathway
    JAK-STAT Pathway
    Glucocorticoid Receptor Signaling

    1 GeneGo (Thomson Reuters) Pathway for TNFRSF10A
        Apoptosis and survival Apoptotic TNF-family pathways

    4 BioSystems Pathways for TNFRSF10A
        Apoptosis Modulation and Signaling
    Kit Receptor Signaling Pathway
    TRAIL signaling pathway
    Direct p53 effectors

    3 Sino Biological Pathways for TNFRSF10A
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    5 Kegg Pathways  (Kegg details for TNFRSF10A):
        Cytokine-cytokine receptor interaction
    Apoptosis
    Natural killer cell mediated cytotoxicity
    Measles
    Influenza A

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF10A (see all 12): 
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              p53 Signaling Pathway in human mouse rat
              TNF Ligands & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFRSF10A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNFRSF10A (O002201, 2, 3 ENSP000002211324) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP8Q147901, 3, ENSP000003512734EBI-518861,EBI-78060 I2D: score=4 STRING: ENSP00000351273
    TNFSF10P505911, 3, ENSP000002412614EBI-518861,EBI-495373 I2D: score=4 STRING: ENSP00000241261
    ARAP1Q96P481, 3, ENSP000003772334EBI-518861,EBI-710003 I2D: score=1 STRING: ENSP00000377233
    FADDQ131582, 3, ENSP000003018384MINT-15426 I2D: score=5 STRING: ENSP00000301838
    CASP10Q928513, ENSP000002861864I2D: score=2 STRING: ENSP00000286186
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process NAS9311998
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process ----
    GO:0007165signal transduction TAS9082980
    GO:0007250activation of NF-kappaB-inducing kinase activity NAS11464292
    GO:0008625extrinsic apoptotic signaling pathway via death domain receptors NAS9311998

    Find genes that share ontologies with TNFRSF10A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TNFRSF10A (TR10A)

    1 IUPHAR Ligand for TNFRSF10A (death receptor 4)    About this table
    LigandTypeActionAffinityPubmed IDs
    TRAIL
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for TNFRSF10A gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tri (d) 85.5 6 10811986 (3), 10762627 (1), 9973225 (1)
    sulindac sulfide 65.7 4 15180942 (2), 16227396 (1), 11559570 (1)
    cd 437 59.6 10 16024638 (6), 11002424 (1), 11156424 (1)
    noxa 55.5 2 20019240 (1), 15314285 (1)
    bortezomib 52.7 6 20126991 (2), 16699949 (1), 17327374 (1), 20442297 (1) (see all 5)
    suberoylanilide hydroxamic acid 46 1 19737941 (1)
    5-aza-2'deoxycytidine 43.4 3 15972852 (1), 12700635 (1), 16357155 (1)
    doxorubicin 43.3 13 17437844 (3), 11090076 (1), 12014636 (1), 12673208 (1) (see all 7)
    mg 132 41.8 1 16520654 (1)
    etoposide 41.7 18 18421578 (6), 10594023 (5), 11090076 (1), 12823542 (1) (see all 6)



    Find genes that share compounds with TNFRSF10A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNFRSF10A gene: 
    NM_003844.3  

    Unigene Cluster for TNFRSF10A:

    Tumor necrosis factor receptor superfamily, member 10a
    Hs.591834  [show with all ESTs]
    Unigene Representative Sequence: NM_003844
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221132(uc003xda.3) ENST00000519862 ENST00000524158
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    Additional mRNA sequence: 

    AK291299.1 BC012866.1 BT006906.1 FJ795027.1 JF729355.1 U90875.1 

    3 DOTS entries:

    DT.308521  DT.91900556  DT.92419206 

    Selected AceView cDNA sequences (see all 50):

    AI298599 BX117817 CO249324 AW291577 BC012866 AA639619 AU099020 NM_003844 
    BF904589 BE832285 BE221280 BF449061 BE746522 BE745635 BV198193 U90875 
    W65310 AA102746 W65340 BV198288 BM829339 BT006906 BX405044 CB144043 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFRSF10A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATACAAAGT
    TNFRSF10A Expression
    About this image

    TNFRSF10A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFRSF10A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591834

    UniProtKB/Swiss-Prot: TR10A_HUMAN, O00220
    Tissue specificity: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small
    intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF10A (see all 12): 
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              p53 Signaling Pathway in human mouse rat
              TNF Ligands & Receptors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF10A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF10A gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf10b1 tumor necrosis factor receptor superfamily, member more 55.84(n)
    41.67(a)
      21933  NM_020275.4  NP_064671.2 
    chicken
    (Gallus gallus)
    Aves TVB6
    Gallus gallus tumor necrosis factor receptor super...
    26(a)
    1 → many
    22(1270094-1276295)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    25(a)
    1 → many
    GL343679.1(101366-110435)
    zebrafish
    (Danio rerio)
    Actinopterygii hdr6
    tnfrsfa6
    hematopoietic death receptor
    tumor necrosis factor receptor superfamily, member...
    19(a)
    17(a)
    many ↔ many
    many ↔ many
    5(29049495-29059630) ENSDARG00000004392
    21(14375999-14422468) ENSDARG00000004451


    ENSEMBL Gene Tree for TNFRSF10A (if available)
    TreeFam Gene Tree for TNFRSF10A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNFRSF10A gene
    TNFRSF10B2  TNFRSF10C2  TNFRSF10D2  
    3 SIMAP similar genes for TNFRSF10A using alignment to 5 protein entries:     TR10A_HUMAN (see all proteins):
    TNFRSF10C    DKFZp686A24188    TNFRSF10B

    Find genes that share paralogs with TNFRSF10A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFRSF10A (see all 872)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3681662511,2
    C--21595112(+) CATGT-/AAAAAA 2 -- ut310--------
    rs1478451111,2
    C--21599020(+) AATGG-/AACACA 1 -- int10--------
    rs1123908661,2
    C--21625353(+) TATTCT/-TTTTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1865525521,2
    C--23050612(+) CTCTTC/TCACTG 1 -- int10--------
    rs736710781,2
    C,F--23051050(+) ACTCTG/CCCTTT 1 -- int12Minor allele frequency- C:0.04WA 120
    rs791033051,2
    F--23051115(+) TGAGTG/ATCTTT 1 -- int11Minor allele frequency- A:0.08WA 118
    rs3692462891,2
    C--23053873(+) GGCTA-/TTTTTT 1 -- int10--------
    rs768665761,2
    C--23063745(+) GTTAAC/TATTGA 1 -- int10--------
    rs1116796811,2
    C--23063861(+) ACTCAC/GTGACT 1 -- int10--------
    rs712085931,2
    C--23065414(+) AAAAAA/-CTAAT 1 -- int11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for TNFRSF10A (23047965 - 23082680 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TNFRSF10A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736750CNV Deletion23290073
    essv19243CNV CNV17122850

    Human Gene Mutation Database (HGMD): TNFRSF10A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFRSF10A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603611    OMIM disorders: --

    3 diseases for TNFRSF10A:    
    About MalaCards
    post-transplant lymphoproliferative disease    colon cancer    lung cancer

    1 disease from the University of Copenhagen DISEASES database for TNFRSF10A:
    Cancer

    Find genes that share disorders with TNFRSF10A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TNFRSF10A gene (see all 61)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 82.7 171 12481428 (2), 15282212 (2), 19706813 (2), 11431320 (2) (see all 99)
    tumors 71.5 253 15897419 (4), 16544055 (3), 19706813 (3), 20068388 (3) (see all 99)
    cancer 60.6 67 15911244 (2), 17143496 (2), 17035413 (2), 19643596 (2) (see all 46)
    colon cancer 42.8 11 15604280 (2), 12473583 (2), 17638911 (2), 10694497 (1) (see all 7)
    adenovirus infections 37.6 2 11382926 (1), 11874999 (1)
    leukemia lymphocytic chronic 36.1 1 16357130 (1)
    malignant glioma 35.9 1 12934082 (1)
    prostate cancer 35.3 19 11212279 (3), 17320696 (2), 18056199 (2), 17431115 (2) (see all 10)
    myeloma 35.1 2 17462628 (1), 11084611 (1)
    ovarian cancer 35 21 15972852 (7), 19959214 (2), 14984943 (2), 20126991 (2) (see all 5)

    Genetic Association Database (GAD): TNFRSF10A
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF10A (36 documents)

    Export disorders for TNFRSF10A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFRSF10A gene, integrated from 10 sources (see all 543):
    (articles sorted by number of sources associating them with TNFRSF10A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The receptor for the cytotoxic ligand TRAIL. (PubMed id 9082980)1, 2, 3, 9 Pan G....Dixit V.M. (Science 1997)
    2. A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan. (PubMed id 16012731)1, 4, 9 Kuraoka K....Yasui W. (Oncol. Rep. 2005)
    3. Association of death receptor 4 haplotype 626C-683C with an increased breast cancer risk. (PubMed id 15975957)1, 4, 9 Frank B....Burwinkel B. (Carcinogenesis 2005)
    4. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. (PubMed id 9430227)1, 2, 9 Chaudhary P.M.... Hood L. (Immunity 1997)
    5. Death receptor 4 variants and colorectal cancer risk. (PubMed id 17035413)1, 4, 9 Frank B....Burwinkel B. (amp 2006)
    6. Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer. (PubMed id 16217763)1, 4, 9 Wolf S....Lichter P. (Int. J. Cancer 2006)
    7. TRAIL-R1 polymorphisms and cancer susceptibility: an evidence-based meta-analysis. (PubMed id 19643596)1, 4, 9 Chen B....Wu J.Q. (Eur. J. Cancer 2009)
    8. Genetic variants in the death receptor 4 gene contribute to susceptibility to bladder cancer. (PubMed id 19070628)1, 4, 9 Wang M....Zhang Z. (Mutat. Res. 2009)
    9. The Glu228Ala polymorphism in the ligand binding domain of death receptor 4 is associated with increased risk for prostate cancer metastases. (PubMed id 18163425)1, 4, 9 Langsenlehner T....Mayer R. (Prostate 2008)
    10. Common death receptor 4 (DR4) polymorphisms do not predispose to ovarian cancer. (PubMed id 15863153)1, 4, 9 Horak P....Krainer M. (Gynecol. Oncol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8797 HGNC: 11904 AceView: TNFRSF10A Ensembl:ENSG00000104689 euGenes: HUgn8797
    ECgene: TNFRSF10A Kegg: 8797 H-InvDB: TNFRSF10A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNFRSF10A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF10A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFRSF10A gene:
    Search GeneIP for patents involving TNFRSF10A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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