Aliases for TNFRSF10A Gene
External Ids for TNFRSF10A Gene
Previous GeneCards Identifiers for TNFRSF10A Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF10A Gene
TNFRSF10A (TNF Receptor Superfamily Member 10a) is a Protein Coding gene. Diseases associated with TNFRSF10A include Posterior Scleritis and Neuronitis. Among its related pathways are Cell surface interactions at the vascular wall and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include transcription factor binding and protease binding. An important paralog of this gene is TNFRSF10B.
UniProtKB/Swiss-Prot for TNFRSF10A Gene
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.