TNFRSF10A Gene
protein-coding GIFtS: 67
GCID: GC08M023048
|
|
tumor necrosis factor receptor superfamily, member 10a
| |
Aliases
for TNFRSF10A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tumor Necrosis Factor Receptor Superfamily, Member 10a1 2 | | TNF-Related Apoptosis-Inducing Ligand Receptor 12 3 | | DR41 2 3 5 | | TRAIL Receptor 12 3 | | APO22 3 5 | | Apo21 | | TRAILR12 3 5 | | Cytotoxic TRAIL Receptor2 | | CD2611 2 | | Tumor Necrosis Factor Receptor Superfamily Member 10A2 | | TRAILR-11 2 | | Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 22 | | Death Receptor 42 3 | | CD261 Antigen3 | | TRAIL-R12 3 | | |
Export aliases for TNFRSF10A gene to outside databasesPrevious GC identifers: GC08M022787 GC08M023403 GC08M023070 GC08M023104 GC08M021594 |
Summaries
for TNFRSF10A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TNFRSF10A:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumornecrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and inducescell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, isrequired for the apoptosis mediated by this protein. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TR10A_HUMAN, O00220Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to theactivated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activationwhich initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.Promotes the activation of NF-kappa-B
Gene Wiki entry for TNFRSF10A
|
Genomic Views
for TNFRSF10A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TNFRSF10A gene promoter:
STAT1 Sp1 ATF-2 MyoD c-Jun STAT1alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for TNFRSF10A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF10A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p21 Ensembl cytogenetic band: 8p21.3 HGNC cytogenetic band: 8p21TNFRSF10A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M023048: view genomic region
(about GC identifiers)
Start:
|
23,047,965 bp from pter |
End:
|
23,082,680 bp from pter |
Size:
|
34,716 bases |
Orientation:
|
minus strand |
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Proteins
for TNFRSF10A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TR10A_HUMAN, O00220 (See
protein sequence)Recommended Name: Tumor necrosis factor receptor superfamily member 10A precursor Size: 468 amino acids; 50089 Da
Subunit: Can interact with TRADD and RIPK1. Interacts with ARAP1
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: A8K5I4 Q53Y72 Q96E62Explore the universe of human proteins at neXtProt for TNFRSF10A: NX_O00220
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00220
TNFRSF10A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003835.3
ENSEMBL proteins: ENSP00000221132 ENSP00000428884
Human Recombinant Protein Products for TNFRSF10A:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
TNFRSF10A for ontologies About GeneDecksing
TNFRSF10A Antibody Products:
Assay Products for TNFRSF10A: |
Protein
Domains /
Families
for TNFRSF10A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TNFRSF10A for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00220ProtoNet protein and cluster: O00220 2 Blocks protein families: IPB000488 Death domain IPB001368 TNFR/CD27/30/40/95 cysteine-rich region
UniProtKB/Swiss-Prot: TR10A_HUMAN, O00220Similarity: Contains 1 death domainSimilarity: Contains 3 TNFR-Cys repeats |
Function
for TNFRSF10A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TR10A_HUMAN, O00220Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to theactivated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activationwhich initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.Promotes the activation of NF-kappa-B Genatlas biochemistry entry for TNFRSF10A:tumor necrosis factor receptor superfamily,member 10A,widely expressed,TNF related,widely expressed,apoptosis inducedligand (TRAIL) receptor 1,TP53 inducible,binding APO2L,inducing a caspase-dependent apoptotic pathway,FADD independent
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
TNFRSF10A for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for TNFRSF10A:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF10A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF10A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TNFRSF10A (NM_003844) | |  | Sino Biological Human cDNA Clone for TNFRSF10A | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNFRSF10A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF10A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF10A |
|
Pathways & Interactions
for TNFRSF10A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | PEDF Induced Signaling | | | 2 | TGF-Beta Pathway | | | 3 | Akt Signaling | | | 4 | Apoptosis and survival_Apoptotic TNF-family pathways | | | 5 | Measles | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TNFRSF10A
2  R&D Systems Pathways for TNFRSF10A
5/16 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF10A (see all 16)
1  GeneGo (Thomson Reuters) Pathway for TNFRSF10A
4  BioSystems Pathways for TNFRSF10A
5 
Kegg Pathways (Kegg details for TNFRSF10A):
TNFRSF10A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF10A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/31 Interacting proteins for TNFRSF10A (O002201, 2, 3 ENSP000002211324) via UniProtKB, MINT, STRING, and/or I2D (see all 31)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CASP8 | Q147901, 3, ENSP000003512734 | EBI-518861,EBI-78060 I2D:
score=4 STRING: ENSP00000351273 | | TNFSF10 | P505911, 3, ENSP000002412614 | EBI-518861,EBI-495373 I2D:
score=4 STRING: ENSP00000241261 | | ARAP1 | Q96P481, 3, ENSP000003772334 | EBI-518861,EBI-710003 I2D:
score=1 STRING: ENSP00000377233 | | FADD | Q131582, 3, ENSP000003018384 | MINT-15426 I2D:
score=5 STRING: ENSP00000301838 | | BCL10 | O959993, ENSP000002710154 | I2D:
score=2 STRING: ENSP00000271015 |
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
TNFRSF10A for ontologies About GeneDecksing
|
Drugs & Compounds
for TNFRSF10A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TNFRSF10A for compounds About GeneDecksing
 Browse Tocris compounds for TNFRSF10A
10/44 Novoseek chemical compound relationships for TNFRSF10A gene (see all 44) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tri (d) |
85.5 |
6 |
10811986 (3), 10762627 (1), 9973225 (1) |
| sulindac sulfide |
65.7 |
4 |
15180942 (2), 16227396 (1), 11559570 (1) |
| cd 437 |
59.6 |
10 |
16024638 (6), 11002424 (1), 11156424 (1) |
| noxa |
55.5 |
2 |
20019240 (1), 15314285 (1) |
| bortezomib |
52.7 |
6 |
20126991 (2), 16699949 (1), 17327374 (1), 20442297 (1) (see all 5) |
| suberoylanilide hydroxamic acid |
46 |
1 |
19737941 (1) |
| 5-aza-2'deoxycytidine |
43.4 |
3 |
15972852 (1), 12700635 (1), 16357155 (1) |
| doxorubicin |
43.3 |
13 |
17437844 (3), 11090076 (1), 12014636 (1), 12673208 (1) (see all 7) |
| mg 132 |
41.8 |
1 |
16520654 (1) |
| etoposide |
41.7 |
18 |
18421578 (6), 10594023 (5), 11090076 (1), 12823542 (1) (see all 6) |
Search CenterWatch for drugs/clinical trials and news about TNFRSF10A / TR10A
|
Transcripts
for TNFRSF10A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TNFRSF10A gene: NM_003844.3 Unigene Cluster for TNFRSF10A: Tumor necrosis factor receptor superfamily, member 10a Hs.591834 [show with all ESTs]Unigene Representative Sequence: NM_0038443 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000221132(uc003xda.3) ENST00000519862 ENST00000524158
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF10A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF10A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TNFRSF10A (NM_003844) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNFRSF10A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF10A |
Additional cDNA sequence: AK291299.1 BC012866.1 BT006906.1 FJ795027.1 JF729355.1 U90875.1 3 DOTS entries: DT.308521 DT.91900556 DT.92419206 24/50 AceView cDNA sequences (see all 50): BX117817 BF904589 AW291577 CO249324 NM_003844 AA639619 AU099020 AI298599 BC012866 BV198288 BE745635 BE832285 BE221280 W65340 BF449061 BE746522 BV198287 BM048377 AW451259 BT006906 BF110510 BM829339 U90875 BX283188
GeneLoc Exon Structure
|
Expression
for TNFRSF10A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TNFRSF10A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATACAAAGT
About this image
See TNFRSF10A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFRSF10A
SOURCE GeneReport for Unigene cluster: Hs.591834
UniProtKB/Swiss-Prot: TR10A_HUMAN, O00220Tissue specificity: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine andthymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells
SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF10A (see all 12):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFRSF10A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNFRSF10A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF10A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF10A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF10A |
Orthologs
for TNFRSF10A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TNFRSF10A gene from 3/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RHOBTB26LOC3789026 |
Rho-related BTB domain containing 2death domain-containing tumor necrosis factor rece... |
25(a)21(a) |
1 ↔ manypossible ortholog |
22(1282197-1286445) 5(14153126-14162752) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
24(a) |
1 → many |
GL343679.1(101366-110435) |
zebrafish
(Danio rerio) |
Actinopterygii |
hdr6tnfrsfa6 |
hematopoietic death receptortumor necrosis factor receptor superfamily, member... |
20(a)19(a) |
many ↔ manymany ↔ many |
5(29049495-29059630) 21(14375999-14422468) |
ENSEMBL Gene Tree for TNFRSF10A (if available)
TreeFam Gene Tree for TNFRSF10A (if available) |
Paralogs
for TNFRSF10A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TNFRSF10A gene
- TNFRSF10B2 TNFRSF10C2 FAS2 TNFRSF10D2
3 SIMAP similar genes for TNFRSF10A using alignment to 5 protein entries: TR10A_HUMAN (see all proteins):TNFRSF10C DKFZp686A24188 TNFRSF10B
TNFRSF10A for paralogs About GeneDecksing
|
Genomic Variants
for TNFRSF10A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TNFRSF10A (23047965 - 23082680 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TNFRSF10A
1 CNV: 3726
Human Gene Mutation Database (HGMD): TNFRSF10A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFRSF10A |
|
Disorders
/ Diseases
for TNFRSF10A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TNFRSF10A for disorders About GeneDecksing
OMIM gene information: 603611
OMIM disorders: --
20/92  diseases for TNFRSF10A (see all 92): About MalaCardspost-transplant lymphoproliferative disease diffuse large b-cell lymphoma human t-cell leukemia virus type 1 hypersensitivity reaction type ii disease
familial adenomatous polyposis b-cell lymphomas non-hodgkin lymphoma soft tissue sarcoma
temporal arteritis squamous cell carcinoma burkitt's lymphoma myeloid leukemia
felty's syndrome malignant glioma mantle cell lymphoma squamous cell carcinoma of the head and neck
esophageal squamous cell carcinoma lymphocytic leukemia giant cell tumor hodgkin's lymphoma
1 disease from the University of Copenhagen DISEASES database for TNFRSF10A:Cancer 10/61 Novoseek disease relationships for TNFRSF10A gene (see all 61) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
82.7 |
171 |
12481428 (2), 15282212 (2), 19706813 (2), 11431320 (2) (see all 99) |
| tumors |
71.5 |
253 |
15897419 (4), 16544055 (3), 19706813 (3), 20068388 (3) (see all 99) |
| cancer |
60.6 |
67 |
15911244 (2), 17143496 (2), 17035413 (2), 19643596 (2) (see all 46) |
| colon cancer |
42.8 |
11 |
15604280 (2), 12473583 (2), 17638911 (2), 10694497 (1) (see all 7) |
| adenovirus infections |
37.6 |
2 |
11382926 (1), 11874999 (1) |
| leukemia lymphocytic chronic |
36.1 |
1 |
16357130 (1) |
| malignant glioma |
35.9 |
1 |
12934082 (1) |
| prostate cancer |
35.3 |
19 |
11212279 (3), 17320696 (2), 18056199 (2), 17431115 (2) (see all 10) |
| myeloma |
35.1 |
2 |
17462628 (1), 11084611 (1) |
| ovarian cancer |
35 |
21 |
15972852 (7), 19959214 (2), 14984943 (2), 20126991 (2) (see all 5) |
Genetic Association Database (GAD): TNFRSF10A
Human Genome Epidemiology (HuGE) Navigator: TNFRSF10A (36 documents)
Export disorders for TNFRSF10A gene to outside databases
|
Publications
for TNFRSF10A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TNFRSF10A gene, integrated from 9 sources (see all 521):
(articles sorted by number of sources associating them with TNFRSF10A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The receptor for the cytotoxic ligand TRAIL. (PubMed id 9082980)1, 2, 3, 9 Pan G....Dixit V.M. (1997)
- A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan. (PubMed id 16012731)1, 4, 9 Kuraoka K....Yasui W. (2005)
- Association of death receptor 4 haplotype 626C-683C with an increased breast cancer risk. (PubMed id 15975957)1, 4, 9 Frank B....Burwinkel B. (2005)
- Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. (PubMed id 9430227)1, 2, 9 Chaudhary P.M.... Hood L. (1997)
- Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer. (PubMed id 16217763)1, 4, 9 Wolf S....Lichter P. (2006)
- Common death receptor 4 (DR4) polymorphisms do not predispose to ovarian cancer. (PubMed id 15863153)1, 4, 9 Horak P....Krainer M. (2005)
- Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. (PubMed id 18165900)1, 2 Simova S.... Andera L. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. (PubMed id 9311998)1, 3 Walczak H.... Rauch C.T. (1997)
|
External Searches for TNFRSF10A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TNFRSF10A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TNFRSF10A gene
(According to HUGE)
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Specialized Databases showing TNFRSF10A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for TNFRSF10A gene:
Search GeneIP for patents involving TNFRSF10A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TNFRSF10A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for TNFRSF10A | | OriGene shRNA RFP for TNFRSF10A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFRSF10A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFRSF10A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TNFRSF10A | | OriGene 3'-UTR Clone for TNFRSF10A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF10A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF10A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TNFRSF10A | | OriGene Custom Protein Services for TNFRSF10A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TNFRSF10A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFRSF10A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF10A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFRSF10A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF10A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF10A |
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 | | | TNFRSF10A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF10A |
|  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF10A |
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