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Aliases for TNFRSF10A Gene

Aliases for TNFRSF10A Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 10a 2 3
  • TRAILR1 3 4 6
  • APO2 3 4 6
  • DR4 3 4 6
  • TNF-Related Apoptosis-Inducing Ligand Receptor 1 3 4
  • Death Receptor 4 3 4
  • TRAIL Receptor 1 3 4
  • TRAIL-R1 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2 3
  • Tumor Necrosis Factor Receptor Superfamily Member 10A 3
  • Cytotoxic TRAIL Receptor 3
  • CD261 Antigen 4
  • TRAILR-1 3
  • CD261 3

External Ids for TNFRSF10A Gene

Summaries for TNFRSF10A Gene

Entrez Gene Summary for TNFRSF10A Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF10A Gene

TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a) is a Protein Coding gene. Diseases associated with TNFRSF10A include post-transplant lymphoproliferative disease and lung cancer. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include transcription factor binding and TRAIL binding. An important paralog of this gene is TNFRSF10D.

UniProtKB/Swiss-Prot for TNFRSF10A Gene

  • Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

Gene Wiki entry for TNFRSF10A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF10A Gene

Genomics for TNFRSF10A Gene

Genomic Location for TNFRSF10A Gene

23,190,452 bp from pter
23,225,167 bp from pter
34,716 bases
Minus strand

Genomic View for TNFRSF10A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF10A Gene

Regulatory Elements for TNFRSF10A Gene

Proteins for TNFRSF10A Gene

  • Protein details for TNFRSF10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 10A
    Protein Accession:
    Secondary Accessions:
    • A8K5I4
    • Q53Y72
    • Q96E62

    Protein attributes for TNFRSF10A Gene

    468 amino acids
    Molecular mass:
    50089 Da
    Quaternary structure:
    • Can interact with TRADD and RIPK1. Interacts with ARAP1. Interacts with HCMV protein UL141; this interaction prevents TNFRSF10A cell surface expression.

neXtProt entry for TNFRSF10A Gene

Proteomics data for TNFRSF10A Gene at MOPED

Post-translational modifications for TNFRSF10A Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn156

Other Protein References for TNFRSF10A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFRSF10A Gene

Domains for TNFRSF10A Gene

Gene Families for TNFRSF10A Gene

  • CD :CD molecules
  • TNFRSF :Tumor necrosis factor receptor superfamily


  • Contains 1 death domain.:
    • O00220
  • Contains 3 TNFR-Cys repeats.:
    • O00220
genes like me logo Genes that share domains with TNFRSF10A: view

Function for TNFRSF10A Gene

Molecular function for TNFRSF10A Gene

GENATLAS Biochemistry: tumor necrosis factor receptor superfamily,member 10A,widely expressed,TNF related,widely expressed,apoptosis induced ligand (TRAIL) receptor 1,TP53 inducible,binding APO2L,inducing a caspase-dependent apoptotic pathway,FADD independent
UniProtKB/Swiss-Prot Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

Gene Ontology (GO) - Molecular Function for TNFRSF10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 21785459
GO:0004872 receptor activity NAS 9311998
GO:0005035 death receptor activity TAS 9082980
GO:0005515 protein binding IPI 17047155
GO:0008134 transcription factor binding IPI 18165900
genes like me logo Genes that share ontologies with TNFRSF10A: view

Phenotypes for TNFRSF10A Gene

GenomeRNAi human phenotypes for TNFRSF10A:
genes like me logo Genes that share phenotypes with TNFRSF10A: view

miRNA for TNFRSF10A Gene

miRTarBase miRNAs that target TNFRSF10A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TNFRSF10A Gene

Localization for TNFRSF10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF10A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TNFRSF10A Gene COMPARTMENTS Subcellular localization image for TNFRSF10A gene
Compartment Confidence
plasma membrane 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for TNFRSF10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 22952982
GO:0016021 integral component of membrane IC 9311998
genes like me logo Genes that share ontologies with TNFRSF10A: view

Pathways for TNFRSF10A Gene

genes like me logo Genes that share pathways with TNFRSF10A: view

Gene Ontology (GO) - Biological Process for TNFRSF10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0007165 signal transduction TAS 9082980
GO:0007166 cell surface receptor signaling pathway TAS --
GO:0007250 activation of NF-kappaB-inducing kinase activity NAS 11464292
genes like me logo Genes that share ontologies with TNFRSF10A: view

Compounds for TNFRSF10A Gene

(1) IUPHAR Ligand for TNFRSF10A Gene

Ligand Type Action Affinity Pubmed IDs
TRAIL None None

(44) Novoseek inferred chemical compound relationships for TNFRSF10A Gene

Compound -log(P) Hits PubMed IDs
tri (d) 85.5 5
sulindac sulfide 65.7 4
cd 437 59.6 8
noxa 55.5 2
bortezomib 52.7 6
genes like me logo Genes that share compounds with TNFRSF10A: view

Transcripts for TNFRSF10A Gene

mRNA/cDNA for TNFRSF10A Gene

Unigene Clusters for TNFRSF10A Gene

Tumor necrosis factor receptor superfamily, member 10a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF10A Gene

No ASD Table

Relevant External Links for TNFRSF10A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF10A Gene

mRNA expression in normal human tissues for TNFRSF10A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNFRSF10A Gene

SOURCE GeneReport for Unigene cluster for TNFRSF10A Gene Hs.591834

mRNA Expression by UniProt/SwissProt for TNFRSF10A Gene

Tissue specificity: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells
genes like me logo Genes that share expressions with TNFRSF10A: view

Orthologs for TNFRSF10A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF10A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFRSF10A 36
  • 99 (n)
  • 98.08 (a)
  • 96 (a)
(Bos Taurus)
Mammalia -- 37
  • 48 (a)
-- 37
  • 42 (a)
  • 65.45 (n)
  • 52.55 (a)
  • 37 (a)
(Mus musculus)
Mammalia Tnfrsf10b 36
  • 55.84 (n)
  • 41.67 (a)
Tnfrsf10b 37
  • 32 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 24 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 31 (a)
(Rattus norvegicus)
Mammalia Tnfrsf10b 36
  • 62.09 (n)
  • 47.87 (a)
(Gallus gallus)
Aves TVB 37
  • 26 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 25 (a)
(Danio rerio)
Actinopterygii hdr 37
  • 19 (a)
tnfrsfa 37
  • 17 (a)
Species with no ortholog for TNFRSF10A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF10A Gene

Gene Tree for TNFRSF10A (if available)
Gene Tree for TNFRSF10A (if available)

Paralogs for TNFRSF10A Gene

Paralogs for TNFRSF10A Gene

Selected SIMAP similar genes for TNFRSF10A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TNFRSF10A: view

Variants for TNFRSF10A Gene

Sequence variations from dbSNP and Humsavar for TNFRSF10A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs17620 -- 23,202,743(-) AGAAC(A/G)TCCTG reference, missense
rs20575 - 23,201,811(-) CAGCA(C/G)AGGGT missense, reference
rs20576 - 23,200,707(-) CATCG(A/C)GTGTG reference, missense
rs1000294 -- 23,222,622(-) GGACC(C/T)TCTCA intron-variant
rs2230229 - 23,191,779(-) TGCAA(A/G)AGAGA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF10A Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
esv2736750 CNV Deletion 23290073

Relevant External Links for TNFRSF10A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for TNFRSF10A Gene

(1) University of Copenhagen DISEASES for TNFRSF10A Gene

(61) Novoseek inferred disease relationships for TNFRSF10A Gene

Disease -log(P) Hits PubMed IDs
necrosis 82.7 105
tumors 71.5 138
cancer 60.6 51
colon cancer 42.8 10
adenovirus infections 37.6 2

Relevant External Links for TNFRSF10A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TNFRSF10A: view

No data available for UniProtKB/Swiss-Prot for TNFRSF10A Gene

Publications for TNFRSF10A Gene

  1. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. (PMID: 9430227) Chaudhary P.M. … Hood L. (Immunity 1997) 3 4 23
  2. Common death receptor 4 (DR4) polymorphisms do not predispose to ovarian cancer. (PMID: 15863153) Horak P. … Krainer M. (Gynecol. Oncol. 2005) 3 23 49
  3. Association of death receptor 4 haplotype 626C-683C with an increased breast cancer risk. (PMID: 15975957) Frank B. … Burwinkel B. (Carcinogenesis 2005) 3 23 49
  4. A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan. (PMID: 16012731) Kuraoka K. … Yasui W. (Oncol. Rep. 2005) 3 23 49
  5. Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer. (PMID: 16217763) Wolf S. … Lichter P. (Int. J. Cancer 2006) 3 23 49

Products for TNFRSF10A Gene

Sources for TNFRSF10A Gene

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