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Aliases for TNFAIP8L3 Gene

Aliases for TNFAIP8L3 Gene

  • Tumor Necrosis Factor, Alpha-Induced Protein 8-Like 3 2 3
  • TNF Alpha-Induced Protein 8-Like Protein 3 4
  • TNFAIP8-Like Protein 3 4

External Ids for TNFAIP8L3 Gene

Previous GeneCards Identifiers for TNFAIP8L3 Gene

  • GC15M049137
  • GC15M051348
  • GC15M028181

Summaries for TNFAIP8L3 Gene

GeneCards Summary for TNFAIP8L3 Gene

TNFAIP8L3 (Tumor Necrosis Factor, Alpha-Induced Protein 8-Like 3) is a Protein Coding gene. An important paralog of this gene is TNFAIP8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFAIP8L3 Gene

Genomics for TNFAIP8L3 Gene

Regulatory Elements for TNFAIP8L3 Gene

Genomic Location for TNFAIP8L3 Gene

51,056,598 bp from pter
51,105,276 bp from pter
48,679 bases
Minus strand

Genomic View for TNFAIP8L3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFAIP8L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP8L3 Gene

Proteins for TNFAIP8L3 Gene

  • Protein details for TNFAIP8L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor alpha-induced protein 8-like protein 3
    Protein Accession:
    Secondary Accessions:
    • Q6ZWD1

    Protein attributes for TNFAIP8L3 Gene

    292 amino acids
    Molecular mass:
    32659 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI27702.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI27703.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85572.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW77412.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNFAIP8L3 Gene

neXtProt entry for TNFAIP8L3 Gene

Proteomics data for TNFAIP8L3 Gene at MOPED

Post-translational modifications for TNFAIP8L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNFAIP8L3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFAIP8L3 Gene

Domains for TNFAIP8L3 Gene

Protein Domains for TNFAIP8L3 Gene


Suggested Antigen Peptide Sequences for TNFAIP8L3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TNFAIP8 family.
  • Belongs to the TNFAIP8 family.
genes like me logo Genes that share domains with TNFAIP8L3: view

No data available for Gene Families for TNFAIP8L3 Gene

Function for TNFAIP8L3 Gene

Phenotypes for TNFAIP8L3 Gene

GenomeRNAi human phenotypes for TNFAIP8L3:
genes like me logo Genes that share phenotypes with TNFAIP8L3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFAIP8L3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TNFAIP8L3 Gene

Localization for TNFAIP8L3 Gene

Subcellular locations from

Jensen Localization Image for TNFAIP8L3 Gene COMPARTMENTS Subcellular localization image for TNFAIP8L3 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TNFAIP8L3 Gene

Pathways for TNFAIP8L3 Gene

SuperPathways for TNFAIP8L3 Gene

No Data Available

Interacting Proteins for TNFAIP8L3 Gene

Gene Ontology (GO) - Biological Process for TNFAIP8L3 Gene


No data available for Pathways by source for TNFAIP8L3 Gene

Transcripts for TNFAIP8L3 Gene

mRNA/cDNA for TNFAIP8L3 Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFAIP8L3 Gene

Tumor necrosis factor, alpha-induced protein 8-like 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFAIP8L3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP8L3 Gene

No ASD Table

Relevant External Links for TNFAIP8L3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFAIP8L3 Gene

mRNA expression in normal human tissues for TNFAIP8L3 Gene

mRNA differential expression in normal tissues according to GTEx for TNFAIP8L3 Gene

This gene is overexpressed in Uterus (5.7) and Fallopian Tube (4.2).

Protein differential expression in normal tissues for TNFAIP8L3 Gene

This gene is overexpressed in Uterus (36.5), Cervix (9.1), Ovary (6.3), and Spleen (6.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TNFAIP8L3 Gene

SOURCE GeneReport for Unigene cluster for TNFAIP8L3 Gene Hs.306343

genes like me logo Genes that share expressions with TNFAIP8L3: view

Expression partners for TNFAIP8L3 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TNFAIP8L3 Gene

Orthologs for TNFAIP8L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNFAIP8L3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC523131 35
  • 93.3 (n)
  • 96.08 (a)
  • 92 (a)
(Canis familiaris)
Mammalia TNFAIP8L3 35
  • 92.32 (n)
  • 95.29 (a)
  • 95 (a)
(Mus musculus)
Mammalia Tnfaip8l3 35
  • 85.95 (n)
  • 90.69 (a)
Tnfaip8l3 16
Tnfaip8l3 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Tnfaip8l3 35
  • 87.75 (n)
  • 92.65 (a)
(Monodelphis domestica)
Mammalia TNFAIP8L3 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia TNFAIP8L3 36
  • 74 (a)
(Pan troglodytes)
Mammalia TNFAIP8L3 36
  • 99 (a)
(Gallus gallus)
Aves TNFAIP8L3 35
  • 77.12 (n)
  • 83.18 (a)
  • 75 (a)
(Anolis carolinensis)
Reptilia TNFAIP8L3 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfaip8l3 35
  • 72.61 (n)
  • 77.23 (a)
(Danio rerio)
Actinopterygii tnfaip8l3 35
  • 69.8 (n)
  • 70.79 (a)
zgc63960 35
tnfaip8l3 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5318 35
fruit fly
(Drosophila melanogaster)
Insecta CG4091 36
  • 37 (a)
Species with no ortholog for TNFAIP8L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFAIP8L3 Gene

Gene Tree for TNFAIP8L3 (if available)
Gene Tree for TNFAIP8L3 (if available)

Paralogs for TNFAIP8L3 Gene

Paralogs for TNFAIP8L3 Gene

(3) SIMAP similar genes for TNFAIP8L3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNFAIP8L3: view

Variants for TNFAIP8L3 Gene

Sequence variations from dbSNP and Humsavar for TNFAIP8L3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs876967 -- 51,107,048(-) gggtc(C/G)caccc upstream-variant-2KB
rs1009882 -- 51,099,519(-) CATAG(C/G)GTTGG intron-variant
rs1124769 -- 51,060,052(-) GTGTT(C/T)ATTCC intron-variant
rs1438926 -- 51,058,948(-) TTAGA(A/C)CCAAT intron-variant
rs1550336 -- 51,072,828(+) aactc(A/G)taagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFAIP8L3 Gene

Variant ID Type Subtype PubMed ID
nsv904214 CNV Gain 21882294
esv34532 CNV Gain 17911159
dgv747e1 CNV Complex 17122850
nsv471243 CNV Gain 18288195
esv2657157 CNV Deletion 23128226

Relevant External Links for TNFAIP8L3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFAIP8L3 Gene

Disorders for TNFAIP8L3 Gene

No disorders were found for TNFAIP8L3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TNFAIP8L3 Gene

Publications for TNFAIP8L3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli E.T. … Goldstein D.B. (Eur. J. Hum. Genet. 2010) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. TIPE3 is the transfer protein of lipid second messengers that promote cancer. (PMID: 25242044) Fayngerts S.A. … Chen Y.H. (Cancer Cell 2014) 3

Products for TNFAIP8L3 Gene

Sources for TNFAIP8L3 Gene

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