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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TNFAIP8L3 Gene

protein-coding GIFtS: 39
GCID: GC15M051348

tumor necrosis factor, alpha-induced protein 8-like 3

Explore 2 diseases affiliated with
TNFAIP8L3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tumor Necrosis Factor, Alpha-Induced Protein 8-Like 3¹ ²
TNF Alpha-Induced Protein 8-Like Protein 3² ³
TNFAIP8-Like Protein 3² ³
FLJ41287¹
Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 3²
Tumor Necrosis Factor, Alpha-Induced Protein 8-Like Protein 3²

External Ids:	HGNC: 20620¹	Entrez Gene: 388121²	Ensembl: ENSG00000183578⁷	UniProtKB: Q5GJ75³

Export aliases for TNFAIP8L3 gene to outside databases

Previous GC identifers: GC15M049137 GC15M028181

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNFAIP8L3 gene promoter:
TBP HFH-3 FOXD1 NF-AT AREB6 FOXI1 FOXC1 FOXJ2 (long isoform) FOXJ2 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNFAIP8L3 promoter sequence

Search SABiosciences Chromatin IP Primers for TNFAIP8L3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFAIP8L3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2 Ensembl cytogenetic band: 15q21.2 HGNC cytogenetic band: 15q21.2

TNFAIP8L3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFAIP8L3 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M051348: view genomic region (about GC identifiers)

Start:	51,348,795 bp from pter	End:	51,397,473 bp from pter
Size:	48,679 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TP8L3_HUMAN, Q5GJ75 (See protein sequence)

Recommended Name: Tumor necrosis factor alpha-induced protein 8-like protein 3

Size: 292 amino acids; 32659 Da

Caution: It is uncertain whether Met-1 or Met-89 is the initiator

Sequence caution: Sequence=AAI27702.1; Type=Erroneous initiation; Sequence=AAI27703.1; Type=Erroneous initiation;

Sequence=BAC85572.1; Type=Erroneous initiation; Sequence=EAW77412.1; Type=Erroneous gene model prediction;

Secondary accessions: Q6ZWD1

Explore the universe of human proteins at neXtProt for TNFAIP8L3: NX_Q5GJ75

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5GJ75

TNFAIP8L3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_997264.2

ENSEMBL proteins:

ENSP00000328016

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNFAIP8L3 for domains About GeneDecksing

1 InterPro domain/family:

IPR008477 DUF758

Graphical View of Domain Structure for InterPro Entry Q5GJ75

ProtoNet protein and cluster: Q5GJ75

UniProtKB/Swiss-Prot: TP8L3_HUMAN, Q5GJ75

Similarity: Belongs to the TNFAIP8 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
1 GenomeRNAi human phenotype for TNFAIP8L3:

Decreased Wnt reporter activit

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TNFAIP8L3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for TNFAIP8L3 gene:

NM_207381.2

Unigene Cluster for TNFAIP8L3:

Tumor necrosis factor, alpha-induced protein 8-like 3

Hs.306343 [show with all ESTs]

Unigene Representative Sequence: NM_207381

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000327536(uc001zyy.3)

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Additional cDNA sequence:

AK123281.1 AY517501.1 BC127701.1 BC127702.1

1 DOTS entry:

DT.75100510

16 AceView cDNA sequences:

AK123281 BQ898183 CA447540 AA339780 NM_207381 BG535411 BF526552 BQ672458

BG107777 AI769691 BI544780 BF744133 AI086592 AI948606 BU191694 AW238360

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNFAIP8L3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCTCAGGG

About this image

TNFAIP8L3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 8 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

Human umbilical vein endothelial cells (HUVEC) (Primary Cell)

Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

HyStem+TGF?3+GDF5-induced E15 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TNFAIP8L3 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.306343

SABiosciences Custom PCR Arrays for TNFAIP8L3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFAIP8L3 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TNFAIP8L3 gene from 4/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TNFAIP8L3¹	tumor necrosis factor, alpha-induced protein 8-like more	75.36(n) 80.68(a)		427499 XM_425071.3 XP_425071.2
lizard (Anolis carolinensis)	Reptilia	TNFAIP8L3⁶	--	79(a)	1 ↔ 1	GL343330.1(648419-649021)
zebrafish (Danio rerio)	Actinopterygii	zgc63960²	hypothetical protein MGC63960	79.75(n)		393322 BC053167.1
fruit fly (Drosophila melanogaster)	Insecta	CG4091⁶	--	37(a)	1 → many	2R(19586469-19589924)

ENSEMBL Gene Tree for TNFAIP8L3 (if available)
TreeFam Gene Tree for TNFAIP8L3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TNFAIP8L3 gene

TNFAIP8² TNFAIP8L2² TNFAIP8L1²

3 SIMAP similar genes for TNFAIP8L3 using alignment to 1 protein entry: TP8L3_HUMAN:

TNFAIP8 TNFAIP8L2 TNFAIP8L1

TNFAIP8L3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185652653^1,2		--	51348403(+)	`ATAGGC/GCTGTG`	1	--	int¹		0	--	--	--	--
rs190066903^1,2		--	51348418(+)	`TATGGC/TATTTT`	1	--	int¹		0	--	--	--	--
rs79496446^1,2	F	--	51348538(+)	`TAAGAC/TTATGA`	1	--	int¹		2		NA EA	240
rs146518023^1,2		--	51348552(+)	`AAAGAC/TGTCAG`	1	--	int¹		0	--	--	--	--
rs10851493^1,2	C,F,A,H	--	51348686(+)	`GGGTTC/GGAGTG`	1	--	int¹		18		NA NS EA WA	1102
rs79047634^1,2	F	--	51348711(+)	`TTCATT/GTTCTT`	1	--	int¹		1		WA	118
rs114277569^1,2	C	--	51348772(+)	`TTATTT/CTGAAT`	1	--	int¹		1		WA	118
rs116196053^1,2		--	51348899(+)	`TCTCCC/TGTGCA`	1	--	ut3¹		1		WA	118
rs140814446^1,2		--	51349057(+)	`CATCAA/GCCTGA`	1	--	ut3¹		0	--	--	--	--
rs200042140^1,2		--	51349098(+)	`AAAAA-/ATTATTAT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TNFAIP8L3 (51348795 - 51397473 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TNFAIP8L3
3 CNVs: 3081 8798 3963

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFAIP8L3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TNFAIP8L3 for disorders About GeneDecksing

2 diseases for TNFAIP8L3: About MalaCards

psoriatic arthritis arthritis

Export disorders for TNFAIP8L3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TNFAIP8L3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TNFAIP8L3)

Utopia: connect your pdf to the dynamic
world of online information

Common genetic variation and performance on standardi zed cognitive tests. (PubMed id 20125193)¹ Cirulli E.T....Goldstein D.B. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 388121	HGNC: 20620	AceView: FLJ41287	Ensembl:ENSG00000183578	euGenes: HUgn388121
ECgene: TNFAIP8L3	H-InvDB: TNFAIP8L3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TNFAIP8L3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFAIP8L3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TNFAIP8L3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TNFAIP8L3 gene:
Search GeneIP for patents involving TNFAIP8L3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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TNFAIP8L3 Gene

tumor necrosis factor, alpha-induced protein 8-like 3

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TNFAIP8L3 Gene

tumor necrosis factor, alpha-induced protein 8-like 3

Aliasesfor TNFAIP8L3 gene

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Genome Databases showing TNFAIP8L3 gene

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for TNFAIP8L3 gene

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for TNFAIP8L3 gene

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for TNFAIP8L3 gene

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for TNFAIP8L3 gene

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for TNFAIP8L3 gene

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for TNFAIP8L3 gene

Expression
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for TNFAIP8L3 gene

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