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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFAIP8L2 Gene

protein-coding   GIFtS: 45
GCID: GC01P151129

Tumor Necrosis Factor, Alpha-Induced Protein 8-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Necrosis Factor, Alpha-Induced Protein 8-Like 21 2     TNFAIP8-Like Protein 22 3
TIPE22 3 5     Inflammation Factor 202
Inflammation Factor Protein 202 3     Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 22
TNF Alpha-Induced Protein 8-Like Protein 22 3     Tumor Necrosis Factor, Alpha-Induced Protein 8-Like Protein 22

External Ids:    HGNC: 262771   Entrez Gene: 796262   Ensembl: ENSG000001631547   OMIM: 6121125   UniProtKB: Q6P5893   

Export aliases for TNFAIP8L2 gene to outside databases

Previous GC identifers: GC01P147943 GC01P149395 GC01P122507


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TNFAIP8L2 Gene: 
TNFAIP8L2 (tumor necrosis factor, alpha-induced protein 8-like 2) is a protein-coding gene. Diseases associated with TNFAIP8L2 include systemic lupus erythematosus, and lupus erythematosus. An important paralog of this gene is TNFAIP8.

UniProtKB/Swiss-Prot: TP8L2_HUMAN, Q6P589
Function: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative
regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system
and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFAIP8L2 gene promoter:
         PPAR-alpha   Spz1   Tal-1   MAZR   RREB-1   Olf-1   Nkx2-5   TGIF   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TNFAIP8L2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFAIP8L2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFAIP8L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.2

TNFAIP8L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFAIP8L2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P151129:  view genomic region     (about GC identifiers)

Start:
151,129,105 bp from pter      End:
151,132,225 bp from pter
Size:
3,121 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TP8L2_HUMAN, Q6P589 (See protein sequence)
Recommended Name: Tumor necrosis factor alpha-induced protein 8-like protein 2  
Size: 184 amino acids; 20556 Da
Subunit: May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the
interaction with CASP8
Sequence caution: Sequence=AAG44785.1; Type=Frameshift; Positions=117;
1 PDB 3D structure from and Proteopedia for TNFAIP8L2:
3F4M (3D)    
Secondary accessions: Q6I9Y0 Q9H2H7 Q9H5G2

Explore the universe of human proteins at neXtProt for TNFAIP8L2: NX_Q6P589

Explore proteomics data for TNFAIP8L2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6P589

  • TNFAIP8L2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNFAIP8L2 Protein Expression
    REFSEQ proteins: NP_078851.2  
    ENSEMBL proteins: 
     ENSP00000357906  

    Human Recombinant Protein Products for TNFAIP8L2: 
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    Novus Biologicals TNFAIP8L2 Protein
    Novus Biologicals TNFAIP8L2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    TNFAIP8L2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008477 DUF758

    Graphical View of Domain Structure for InterPro Entry Q6P589

    ProtoNet protein and cluster: Q6P589

    UniProtKB/Swiss-Prot: TP8L2_HUMAN, Q6P589
    Domain: The central region was initially thought to constitute a DED (death effector) domain. However,
    3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED
    (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding
    Similarity: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily


    TNFAIP8L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TP8L2_HUMAN, Q6P589
    Function: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative
    regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system
    and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By
    similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    TNFAIP8L2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TNFAIP8L2:
     Increased S DNA content, incre 

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tnfaip8l2):
     cellular  digestive/alimentary  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  respiratory system 

    TNFAIP8L2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tnfaip8l2tm1Yhcn for TNFAIP8L2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNFAIP8L2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNFAIP8L2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFAIP8L2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFAIP8L2 

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFAIP8L2:
    hsa-miR-4264 hsa-miR-1244 hsa-miR-185* hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidTNFAIP8L2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of TNFAIP8L2 

    Cell Line
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    Search LifeMap BioReagents cell lines for TNFAIP8L2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP8L2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TNFAIP8L2

    1 Interacting protein for TNFAIP8L2 (Q6P5893) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP8Q147903I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045087innate immune response IEA--
    GO:0050728negative regulation of inflammatory response IEA--
    GO:0050868negative regulation of T cell activation IEA--

    TNFAIP8L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFAIP8L2 (TP8L2)

    Search CenterWatch for drugs/clinical trials and news about TNFAIP8L2 / TP8L2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNFAIP8L2 gene: 
    NM_024575.4  

    Unigene Clusters for TNFAIP8L2:

    Tumor necrosis factor, alpha-induced protein 8-like 2
    Hs.432360  [show with all ESTs], Hs.744751
    Unigene Representative Sequences: BC063014, CR457375
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368910(uc001ewx.2)
    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFAIP8L2:
    hsa-miR-4264 hsa-miR-1244 hsa-miR-185* hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidTNFAIP8L2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFAIP8L2
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                         Customized lentivirus expression plasmids for stable overexpression of TNFAIP8L2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFAIP8L2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFAIP8L2

    Additional mRNA sequence: 

    AF548003.1 CR457375.1 

    7 DOTS entries:

    DT.313060  DT.121409556  DT.75183784  DT.121409579  DT.75113669  DT.121409566  DT.70105220 

    24/241 AceView cDNA sequences (see all 241):

    AI090123 CA389159 AI298776 BM826325 BU730826 BU581432 BQ574859 BC012013 
    AI597799 AI349378 NM_024041 AI359578 BU754466 AI471219 BE207308 AA085630 
    BX357796 BC000264 AL833373 AI151019 BU736413 BE255227 BQ576117 BM745075 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFAIP8L2 expression in normal human tissues (normalized intensities)      TNFAIP8L2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAACCAAGG
    TNFAIP8L2 Expression
    About this image


    TNFAIP8L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Spleen (Hematopoietic System)

    See TNFAIP8L2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFAIP8L2

    SOURCE GeneReport for Unigene clusters: Hs.432360 Hs.744751
        SABiosciences Custom PCR Arrays for TNFAIP8L2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP8L2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TNFAIP8L2 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfaip8l21 , 5 tumor necrosis factor, alpha-induced protein 8-like more1, 5 86.23(n)1
    94.02(a)1
      3 (40.74 cM)5
    697691  NM_027206.21  NP_081482.11 
     951395215 
    lizard
    (Anolis carolinensis)
    Reptilia TNFAIP8L26
    Uncharacterized protein
    66(a)
    1 ↔ 1
    GL343668.1(211517-212077)
    zebrafish
    (Danio rerio)
    Actinopterygii tnfaip8l2b1 tumor necrosis factor, alpha-induced protein 8, like more 62.66(n)
    63.39(a)
      393345  NM_200374.1  NP_956668.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG40916
    --
    34(a)
    1 → many
    2R(19586469-19589924)


    ENSEMBL Gene Tree for TNFAIP8L2 (if available)
    TreeFam Gene Tree for TNFAIP8L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFAIP8L2 gene
    TNFAIP82  TNFAIP8L32  TNFAIP8L12  
    3 SIMAP similar genes for TNFAIP8L2 using alignment to 1 protein entry:     TP8L2_HUMAN:
    TNFAIP8    TNFAIP8L3    TNFAIP8L1

    TNFAIP8L2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TNFAIP8L2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2n68CNV Loss17160897
    nsv522840CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFAIP8L2
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFAIP8L2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612112    OMIM disorders: --

    4 diseases for TNFAIP8L2:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    hepatitis b    hepatitis


    TNFAIP8L2 for disorders           About GeneDecksing


    Export disorders for TNFAIP8L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFAIP8L2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with TNFAIP8L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TIPE2, a novel biomarker for clinical chronic kidney a llograft rejection. (PubMed id 23009108)1 Jia L....Ou Y. (2013)
    2. The anti-inflammatory TIPE2 is an inhibitor of the onc ogenic Ras. (PubMed id 22326055)1 Gus-Brautbar Y....Chen Y.H. (2012)
    3. The unique expression profile of human TIPE2 suggests new functions beyond its role in immune regulation. (PubMed id 21459448)1 Zhang L....Zhang L. (2011)
    4. Roles of TIPE2 in hepatitis B virus-induced hepatic i nflammation in humans and mice. (PubMed id 21466895)1 Xi W....Liu S. (2011)
    5. Tissue-specific expression of TIPE2 provides insights into its function. (PubMed id 20663561)1 Zhang G....Liu S. (2010)
    6. Crystal structure of TIPE2 provides insights into immune homeostasis. (PubMed id 19079267)2 Zhang X.... Shi Y. (2009)
    7. TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. (PubMed id 18455983)2 Sun H.... Chen Y.H. (2008)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79626 HGNC: 26277 AceView: SCNM1andFLJ23467 Ensembl:ENSG00000163154 euGenes: HUgn79626
    ECgene: TNFAIP8L2 H-InvDB: TNFAIP8L2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFAIP8L2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFAIP8L2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNFAIP8L2 gene:
    Search GeneIP for patents involving TNFAIP8L2

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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