TNFAIP8L2 Gene
protein-coding GIFtS: 44
GCID: GC01P151129
|
|
tumor necrosis factor, alpha-induced protein 8-like 2
| |
Aliases
for TNFAIP8L2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tumor Necrosis Factor, Alpha-Induced Protein 8-Like 21 2 | | FLJ234671 | | TIPE22 3 5 | | Inflammation Factor 202 | | Inflammation Factor Protein 202 3 | | Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 22 | | TNF Alpha-Induced Protein 8-Like Protein 22 3 | | Tumor Necrosis Factor, Alpha-Induced Protein 8-Like Protein 22 | | TNFAIP8-Like Protein 22 3 | | |
Export aliases for TNFAIP8L2 gene to outside databasesPrevious GC identifers: GC01P147943 GC01P149395 GC01P122507 |
Summaries
for TNFAIP8L2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TP8L2_HUMAN, Q6P589Function: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negativeregulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system andmaintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (Bysimilarity)
|
Genomic Views
for TNFAIP8L2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TNFAIP8L2 gene promoter:
PPAR-alpha Spz1 Tal-1 MAZR RREB-1 Olf-1 Nkx2-5 TGIF E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for TNFAIP8L2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFAIP8L2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.2TNFAIP8L2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P151129: view genomic region
(about GC identifiers)
Start:
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151,129,105 bp from pter |
End:
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151,132,225 bp from pter |
Size:
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3,121 bases |
Orientation:
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plus strand |
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Proteins
for TNFAIP8L2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TP8L2_HUMAN, Q6P589 (See
protein sequence)Recommended Name: Tumor necrosis factor alpha-induced protein 8-like protein 2 Size: 184 amino acids; 20556 Da
Subunit: May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce theinteraction with CASP8
Sequence caution: Sequence=AAG44785.1; Type=Frameshift; Positions=117;
1 PDB 3D structure from  and Proteopedia  for TNFAIP8L2:3F4M (3D)
Secondary accessions: Q6I9Y0 Q9H2H7 Q9H5G2Explore the universe of human proteins at neXtProt for TNFAIP8L2: NX_Q6P589
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P589
TNFAIP8L2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078851.2
ENSEMBL proteins: ENSP00000357906
Human Recombinant Protein Products for TNFAIP8L2:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
TNFAIP8L2 for ontologies About GeneDecksing
TNFAIP8L2 Antibody Products:
Assay Products for TNFAIP8L2: |
Protein
Domains /
Families
for TNFAIP8L2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TNFAIP8L2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6P589ProtoNet protein and cluster: Q6P589 UniProtKB/Swiss-Prot: TP8L2_HUMAN, Q6P589Domain: The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structuredata reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector)domain. It consists of a large, hydrophobic central cavity that is poised for cofactor bindingSimilarity: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily |
Function
for TNFAIP8L2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TP8L2_HUMAN, Q6P589Function: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negativeregulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system andmaintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (Bysimilarity) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
TNFAIP8L2 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for TNFAIP8L2:
9 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tnfaip8l2):
TNFAIP8L2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Tnfaip8l2tm1Yhcn for TNFAIP8L2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFAIP8L2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFAIP8L2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for TNFAIP8L2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFAIP8L2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP8L2 |
|
Pathways & Interactions
for TNFAIP8L2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TNFAIP8L2
1 Interacting protein for TNFAIP8L2 (Q6P5893) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045087 | innate immune response |
IEA | -- | | GO:0050728 | negative regulation of inflammatory response |
IEA | -- | | GO:0050868 | negative regulation of T cell activation |
IEA | -- |
TNFAIP8L2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TNFAIP8L2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TNFAIP8L2
Search CenterWatch for drugs/clinical trials and news about TNFAIP8L2 / TP8L2
|
Transcripts
for TNFAIP8L2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TNFAIP8L2 gene: NM_024575.4 Unigene Clusters for TNFAIP8L2: Tumor necrosis factor, alpha-induced protein 8-like 2 Hs.432360 [show with all ESTs], Hs.744751 Unigene Representative Sequences: BC063014, CR4573751 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000368910(uc001ewx.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFAIP8L2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFAIP8L2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TNFAIP8L2 (NM_024575) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNFAIP8L2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFAIP8L2 |
Additional cDNA sequence: AF548003.1 CR457375.1 5 DOTS entries: DT.313060 DT.121409556 DT.75183784 DT.121409579 DT.121409566 24/241 AceView cDNA sequences (see all 241): AI357271 BM988027 BU754466 AI298776 AI298607 AA995382 BI833715 BM923832 BQ936887 BU730826 BM745075 BC000264 AI151019 AA085630 AW006145 AI471219 BM826325 BX357796 CA389159 BF594059 BC012013 AI597799 NM_001002234 CR607615
GeneLoc Exon Structure
|
Expression
for TNFAIP8L2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TNFAIP8L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAACCAAGG
About this image
See TNFAIP8L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFAIP8L2
SOURCE GeneReport for Unigene clusters: Hs.432360 Hs.744751
SABiosciences Custom PCR Arrays for TNFAIP8L2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFAIP8L2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNFAIP8L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFAIP8L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFAIP8L2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP8L2 |
Orthologs
for TNFAIP8L2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TNFAIP8L2 gene from 3/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TNFAIP8L26 |
-- |
66(a) |
1 ↔ 1 |
GL343668.1(211517-212077) |
zebrafish
(Danio rerio) |
Actinopterygii |
tnfaip8l2b1 |
tumor necrosis factor, alpha-induced protein 8, like more |
62.66(n)
63.39(a) |
|
393345 NM_200374.1 NP_956668.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG40916 |
-- |
34(a) |
1 → many |
2R(19586469-19589924) |
ENSEMBL Gene Tree for TNFAIP8L2 (if available)
TreeFam Gene Tree for TNFAIP8L2 (if available) |
Paralogs
for TNFAIP8L2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TNFAIP8L2 gene
- TNFAIP82 TNFAIP8L32 TNFAIP8L12
3 SIMAP similar genes for TNFAIP8L2 using alignment to 1 protein entry: TP8L2_HUMAN:TNFAIP8 TNFAIP8L3 TNFAIP8L1
TNFAIP8L2 for paralogs About GeneDecksing
|
Genomic Variants
for TNFAIP8L2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TNFAIP8L2 (151129105 - 151132225 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TNFAIP8L2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFAIP8L2 |
|
Disorders
/ Diseases
for TNFAIP8L2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TNFAIP8L2 for disorders About GeneDecksing
OMIM gene information: 612112
OMIM disorders: --
4  diseases for TNFAIP8L2: About MalaCardssystemic lupus erythematosus lupus erythematosus hepatitis b hepatitis
Export disorders for TNFAIP8L2 gene to outside databases
|
Publications
for TNFAIP8L2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TNFAIP8L2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TNFAIP8L2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The anti-inflammatory TIPE2 is an inhibitor of the onc ogenic Ras. (PubMed id 22326055)1 Gus-Brautbar Y....Chen Y.H. (2012)
- The unique expression profile of human TIPE2 suggests new functions beyond its role in immune regulation. (PubMed id 21459448)1 Zhang L....Zhang L. (2011)
- Roles of TIPE2 in hepatitis B virus-induced hepatic i nflammation in humans and mice. (PubMed id 21466895)1 Xi W....Liu S. (2011)
- Tissue-specific expression of TIPE2 provides insights into its function. (PubMed id 20663561)1 Zhang G....Liu S. (2010)
- Crystal structure of TIPE2 provides insights into immune homeostasis. (PubMed id 19079267)2 Zhang X.... Shi Y. (2009)
- TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. (PubMed id 18455983)2 Sun H.... Chen Y.H. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for TNFAIP8L2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TNFAIP8L2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TNFAIP8L2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TNFAIP8L2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TNFAIP8L2 gene:
Search GeneIP for patents involving TNFAIP8L2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TNFAIP8L2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TNFAIP8L2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFAIP8L2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFAIP8L2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFAIP8L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFAIP8L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFAIP8L2 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP8L2 |
|  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFAIP8L2 |
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