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Aliases for TNFAIP8L2 Gene

Aliases for TNFAIP8L2 Gene

  • TNF Alpha Induced Protein 8 Like 2 2 3 5
  • Tumor Necrosis Factor, Alpha-Induced Protein 8-Like 2 2 3
  • TNF Alpha-Induced Protein 8-Like Protein 2 3 4
  • Inflammation Factor Protein 20 3 4
  • TNFAIP8-Like Protein 2 3 4
  • TIPE2 3 4
  • Tumor Necrosis Factor, Alpha-Induced Protein 8-Like Protein 2 3
  • Tumor Necrosis Factor, Alpha Induced Protein 8 Like 2 3
  • Inflammation Factor 20 3

External Ids for TNFAIP8L2 Gene

Previous GeneCards Identifiers for TNFAIP8L2 Gene

  • GC01P147943
  • GC01P149395
  • GC01P122507

Summaries for TNFAIP8L2 Gene

GeneCards Summary for TNFAIP8L2 Gene

TNFAIP8L2 (TNF Alpha Induced Protein 8 Like 2) is a Protein Coding gene. An important paralog of this gene is TNFAIP8.

UniProtKB/Swiss-Prot for TNFAIP8L2 Gene

  • Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFAIP8L2 Gene

Genomics for TNFAIP8L2 Gene

Regulatory Elements for TNFAIP8L2 Gene

Promoters for TNFAIP8L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNFAIP8L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNFAIP8L2 Gene

Chromosome:
1
Start:
151,156,629 bp from pter
End:
151,159,749 bp from pter
Size:
3,121 bases
Orientation:
Plus strand

Genomic View for TNFAIP8L2 Gene

Genes around TNFAIP8L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFAIP8L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFAIP8L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP8L2 Gene

Proteins for TNFAIP8L2 Gene

  • Protein details for TNFAIP8L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P589-TP8L2_HUMAN
    Recommended name:
    Tumor necrosis factor alpha-induced protein 8-like protein 2
    Protein Accession:
    Q6P589
    Secondary Accessions:
    • Q6I9Y0
    • Q9H2H7
    • Q9H5G2

    Protein attributes for TNFAIP8L2 Gene

    Size:
    184 amino acids
    Molecular mass:
    20556 Da
    Quaternary structure:
    • May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8.
    SequenceCaution:
    • Sequence=AAG44785.1; Type=Frameshift; Positions=117; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNFAIP8L2 Gene

neXtProt entry for TNFAIP8L2 Gene

Proteomics data for TNFAIP8L2 Gene at MOPED

Post-translational modifications for TNFAIP8L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNFAIP8L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TNFAIP8L2 Gene

Domains & Families for TNFAIP8L2 Gene

Protein Domains for TNFAIP8L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNFAIP8L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P589

UniProtKB/Swiss-Prot:

TP8L2_HUMAN :
  • The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.
  • Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
Domain:
  • The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.
Family:
  • Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
genes like me logo Genes that share domains with TNFAIP8L2: view

No data available for Gene Families for TNFAIP8L2 Gene

Function for TNFAIP8L2 Gene

Molecular function for TNFAIP8L2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).
genes like me logo Genes that share phenotypes with TNFAIP8L2: view

Animal Models for TNFAIP8L2 Gene

MGI Knock Outs for TNFAIP8L2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFAIP8L2 Gene

Localization for TNFAIP8L2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFAIP8L2 Gene COMPARTMENTS Subcellular localization image for TNFAIP8L2 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TNFAIP8L2 Gene

Pathways & Interactions for TNFAIP8L2 Gene

SuperPathways for TNFAIP8L2 Gene

No Data Available

Interacting Proteins for TNFAIP8L2 Gene

Gene Ontology (GO) - Biological Process for TNFAIP8L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050728 negative regulation of inflammatory response IEA,IBA --
genes like me logo Genes that share ontologies with TNFAIP8L2: view

No data available for Pathways by source and SIGNOR curated interactions for TNFAIP8L2 Gene

Drugs & Compounds for TNFAIP8L2 Gene

No Compound Related Data Available

Transcripts for TNFAIP8L2 Gene

mRNA/cDNA for TNFAIP8L2 Gene

(1) REFSEQ mRNAs :
(241) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP8L2 Gene

No ASD Table

Relevant External Links for TNFAIP8L2 Gene

GeneLoc Exon Structure for
TNFAIP8L2
ECgene alternative splicing isoforms for
TNFAIP8L2

Expression for TNFAIP8L2 Gene

mRNA expression in normal human tissues for TNFAIP8L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNFAIP8L2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.3) and Bone marrow mesenchymal stem cell (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNFAIP8L2 Gene



SOURCE GeneReport for Unigene cluster for TNFAIP8L2 Gene Hs.432360

genes like me logo Genes that share expression patterns with TNFAIP8L2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TNFAIP8L2 Gene

Orthologs for TNFAIP8L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNFAIP8L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFAIP8L2 35
  • 99.28 (n)
  • 99.46 (a)
TNFAIP8L2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNFAIP8L2 36
  • 93 (a)
OneToOne
TNFAIP8L2 35
  • 88.41 (n)
  • 93.48 (a)
dog
(Canis familiaris)
Mammalia TNFAIP8L2 35
  • 89.13 (n)
  • 93.48 (a)
TNFAIP8L2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnfaip8l2 16
Tnfaip8l2 36
  • 94 (a)
OneToOne
Tnfaip8l2 35
  • 86.23 (n)
  • 94.02 (a)
oppossum
(Monodelphis domestica)
Mammalia TNFAIP8L2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFAIP8L2 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfaip8l2 35
  • 86.96 (n)
  • 92.39 (a)
lizard
(Anolis carolinensis)
Reptilia TNFAIP8L2 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfaip8l2 35
  • 63.59 (n)
  • 63.59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8642 35
zebrafish
(Danio rerio)
Actinopterygii tnfaip8l2b 35
  • 62.66 (n)
  • 63.39 (a)
tnfaip8l2a 36
  • 59 (a)
OneToMany
tnfaip8l2b 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4091 36
  • 34 (a)
OneToMany
Species with no ortholog for TNFAIP8L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFAIP8L2 Gene

ENSEMBL:
Gene Tree for TNFAIP8L2 (if available)
TreeFam:
Gene Tree for TNFAIP8L2 (if available)

Paralogs for TNFAIP8L2 Gene

Paralogs for TNFAIP8L2 Gene

(3) SIMAP similar genes for TNFAIP8L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNFAIP8L2: view

Variants for TNFAIP8L2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TNFAIP8L2 Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV Gain 19592680
dgv2n68 CNV Loss 17160897

Variation tolerance for TNFAIP8L2 Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFAIP8L2 Gene

HapMap Linkage Disequilibrium report
TNFAIP8L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TNFAIP8L2 Gene

Disorders for TNFAIP8L2 Gene

Relevant External Links for TNFAIP8L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFAIP8L2

No disorders were found for TNFAIP8L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFAIP8L2 Gene

Publications for TNFAIP8L2 Gene

  1. The TIPE (TNFAIP8) family in inflammation, immunity, and cancer. (PMID: 21924498) Lou Y. … Liu S. (Mol. Immunol. 2011) 2 3 67
  2. TIPE2 protein negatively regulates HBV-specific CD8a8_ T lymphocyte functions in humans. (PMID: 25499447) Zhang W. … Liu S. (Mol. Immunol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Downregulated TIPE2 is associated with poor prognosis and promotes cell proliferation in non-small cell lung cancer. (PMID: 25542151) Li Y. … Wang H. (Biochem. Biophys. Res. Commun. 2015) 3
  5. TIPE2 inhibits TNF-I+-induced hepatocellular carcinoma cell metastasis via Erk1/2 downregulation and NF-I_B activation. (PMID: 25339267) Zhang Y.H. … Gao F.G. (Int. J. Oncol. 2015) 3

Products for TNFAIP8L2 Gene

Sources for TNFAIP8L2 Gene

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