Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TNFAIP8L1 Gene

Aliases for TNFAIP8L1 Gene

  • Tumor Necrosis Factor, Alpha-Induced Protein 8-Like 1 2 3
  • TNF Alpha-Induced Protein 8-Like Protein 1 3 4
  • Oxidative Stress-Regulated Gene-Beta 3 4
  • TNFAIP8-Like Protein 1 3 4
  • Oxy-Beta 3 4
  • TIPE1 3 4
  • Tumor Necrosis Factor, Alpha-Induced Protein 8-Like Protein 1 3
  • Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 1 3

External Ids for TNFAIP8L1 Gene

Previous GeneCards Identifiers for TNFAIP8L1 Gene

  • GC19P004591
  • GC19P004400

Summaries for TNFAIP8L1 Gene

GeneCards Summary for TNFAIP8L1 Gene

TNFAIP8L1 (Tumor Necrosis Factor, Alpha-Induced Protein 8-Like 1) is a Protein Coding gene. An important paralog of this gene is TNFAIP8.

UniProtKB/Swiss-Prot for TNFAIP8L1 Gene

  • Acts as a negative regulator of mTOR activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFAIP8L1 Gene

Genomics for TNFAIP8L1 Gene

Regulatory Elements for TNFAIP8L1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNFAIP8L1 Gene

Start:
4,639,515 bp from pter
End:
4,655,568 bp from pter
Size:
16,054 bases
Orientation:
Plus strand

Genomic View for TNFAIP8L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFAIP8L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP8L1 Gene

Proteins for TNFAIP8L1 Gene

  • Protein details for TNFAIP8L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVP5-TP8L1_HUMAN
    Recommended name:
    Tumor necrosis factor alpha-induced protein 8-like protein 1
    Protein Accession:
    Q8WVP5
    Secondary Accessions:
    • D6W627

    Protein attributes for TNFAIP8L1 Gene

    Size:
    186 amino acids
    Molecular mass:
    20827 Da
    Quaternary structure:
    • Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.

neXtProt entry for TNFAIP8L1 Gene

Proteomics data for TNFAIP8L1 Gene at MOPED

Post-translational modifications for TNFAIP8L1 Gene

No Post-translational modifications

Other Protein References for TNFAIP8L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFAIP8L1 Gene

Domains for TNFAIP8L1 Gene

Protein Domains for TNFAIP8L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNFAIP8L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WVP5

UniProtKB/Swiss-Prot:

TP8L1_HUMAN :
  • Q8WVP5
Family:
  • Belongs to the TNFAIP8 family.
genes like me logo Genes that share domains with TNFAIP8L1: view

No data available for Gene Families for TNFAIP8L1 Gene

Function for TNFAIP8L1 Gene

Molecular function for TNFAIP8L1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of mTOR activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated by oxidative stress (OS) at both transcriptional and translational levels.

Gene Ontology (GO) - Molecular Function for TNFAIP8L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TNFAIP8L1: view

Phenotypes for TNFAIP8L1 Gene

GenomeRNAi human phenotypes for TNFAIP8L1:
genes like me logo Genes that share phenotypes with TNFAIP8L1: view

Animal Model Products

CRISPR Products

miRNA for TNFAIP8L1 Gene

miRTarBase miRNAs that target TNFAIP8L1

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate TNFAIP8L1
    • Block miRNA regulation of TNFAIP8L1 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for TNFAIP8L1

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TNFAIP8L1 Gene

    Localization for TNFAIP8L1 Gene

    Subcellular locations from UniProtKB/Swiss-Prot for TNFAIP8L1 Gene

    Cytoplasm.

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for TNFAIP8L1 Gene COMPARTMENTS Subcellular localization image for TNFAIP8L1 gene
    Compartment Confidence
    cytosol 1
    extracellular 1
    mitochondrion 1

    Gene Ontology (GO) - Cellular Components for TNFAIP8L1 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0005737 cytoplasm ISS --
    genes like me logo Genes that share ontologies with TNFAIP8L1: view

    Pathways for TNFAIP8L1 Gene

    SuperPathways for TNFAIP8L1 Gene

    No Data Available

    PCR Array Products

    • Pathway & Disease-focused RT² Profiler PCR Arrays
      • Molecular Toxicology PathwayFinder 384HT in human,mouse,rat

    Gene Ontology (GO) - Biological Process for TNFAIP8L1 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0032007 negative regulation of TOR signaling ISS --
    genes like me logo Genes that share ontologies with TNFAIP8L1: view

    No data available for Pathways by source for TNFAIP8L1 Gene

    Transcripts for TNFAIP8L1 Gene

    Unigene Clusters for TNFAIP8L1 Gene

    Tumor necrosis factor, alpha-induced protein 8-like 1:
    Representative Sequences:

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate TNFAIP8L1
      • Block miRNA regulation of TNFAIP8L1 using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for TNFAIP8L1

      Primer Products

      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP8L1 Gene

      No ASD Table

      Relevant External Links for TNFAIP8L1 Gene

      GeneLoc Exon Structure for
      TNFAIP8L1
      ECgene alternative splicing isoforms for
      TNFAIP8L1

      Expression for TNFAIP8L1 Gene

      mRNA expression in normal human tissues for TNFAIP8L1 Gene

      mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

      mRNA differential expression in normal tissues according to GTEx for TNFAIP8L1 Gene

      This gene is overexpressed in Colon - Sigmoid (4.3).

      Protein differential expression in normal tissues for TNFAIP8L1 Gene

      This gene is overexpressed in Peripheral blood mononuclear cells (41.0) and Bone (23.1).

      Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNFAIP8L1 Gene

      SOURCE GeneReport for Unigene cluster for TNFAIP8L1 Gene Hs.465643

      mRNA Expression by UniProt/SwissProt for TNFAIP8L1 Gene

      Q8WVP5-TP8L1_HUMAN
      Tissue specificity: High expression detected in most carcinoma cell lines, especially in cells transformed with virus genomes.
      genes like me logo Genes that share expressions with TNFAIP8L1: view

      Expression partners for TNFAIP8L1 Gene

      In Situ Assay Products

      Orthologs for TNFAIP8L1 Gene

      This gene was present in the common ancestor of animals.

      Orthologs for TNFAIP8L1 Gene

      Organism Taxonomy Gene Similarity Type Details
      cow
      (Bos Taurus)
      Mammalia TNFAIP8L1 35
      • 87.46 (n)
      • 84.41 (a)
      TNFAIP8L1 36
      • 84 (a)
      OneToOne
      dog
      (Canis familiaris)
      Mammalia TNFAIP8L1 35
      • 89.96 (n)
      • 89.78 (a)
      TNFAIP8L1 36
      • 51 (a)
      OneToOne
      mouse
      (Mus musculus)
      Mammalia Tnfaip8l1 35
      • 81 (n)
      • 81.72 (a)
      Tnfaip8l1 16
      Tnfaip8l1 36
      • 82 (a)
      OneToOne
      chimpanzee
      (Pan troglodytes)
      Mammalia TNFAIP8L1 35
      • 100 (n)
      • 100 (a)
      TNFAIP8L1 36
      • 100 (a)
      OneToOne
      rat
      (Rattus norvegicus)
      Mammalia Tnfaip8l1 35
      • 78.67 (n)
      • 77.96 (a)
      oppossum
      (Monodelphis domestica)
      Mammalia TNFAIP8L1 36
      • 66 (a)
      OneToOne
      platypus
      (Ornithorhynchus anatinus)
      Mammalia TNFAIP8L1 36
      • 68 (a)
      OneToOne
      chicken
      (Gallus gallus)
      Aves TNFAIP8L1 35
      • 74.55 (n)
      • 69.89 (a)
      TNFAIP8L1 36
      • 70 (a)
      OneToOne
      zebrafish
      (Danio rerio)
      Actinopterygii tnfaip8l1 35
      • 70.07 (n)
      • 68.28 (a)
      zgc55331 35
      tnfaip8 36
      • 68 (a)
      OneToOne
      fruit fly
      (Drosophila melanogaster)
      Insecta CG4091 36
      • 30 (a)
      OneToMany
      Species with no ortholog for TNFAIP8L1:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • rainbow trout (Oncorhynchus mykiss)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)

      Evolution for TNFAIP8L1 Gene

      ENSEMBL:
      Gene Tree for TNFAIP8L1 (if available)
      TreeFam:
      Gene Tree for TNFAIP8L1 (if available)

      Paralogs for TNFAIP8L1 Gene

      Paralogs for TNFAIP8L1 Gene

      Selected SIMAP similar genes for TNFAIP8L1 Gene using alignment to 1 proteins:

      genes like me logo Genes that share paralogs with TNFAIP8L1: view

      Variants for TNFAIP8L1 Gene

      Sequence variations from dbSNP and Humsavar for TNFAIP8L1 Gene

      SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
      rs1060555 -- 4,652,810(+) GACTA(C/G)GGGTT utr-variant-3-prime
      rs2003489 -- 4,655,851(-) GGCAC(C/T)CGCCG downstream-variant-500B
      rs2363266 -- 4,647,799(-) AAAAA(A/T)TTTTT intron-variant
      rs2363267 -- 4,644,229(-) ATTTT(A/T)TTTTT intron-variant
      rs2363268 -- 4,644,228(-) TTTTA(A/T)TTTTT intron-variant

      Structural Variations from Database of Genomic Variants (DGV) for TNFAIP8L1 Gene

      Variant ID Type Subtype PubMed ID
      dgv3678n71 CNV Loss 21882294
      nsv428361 CNV Loss 18775914
      dgv3679n71 CNV Loss 21882294
      nsv910847 CNV Loss 21882294
      nsv526746 CNV Loss 19592680
      nsv910848 CNV Loss 21882294
      nsv910849 CNV Loss 21882294
      dgv3680n71 CNV Loss 21882294
      dgv3681n71 CNV Loss 21882294
      nsv910856 CNV Loss 21882294
      nsv833721 CNV Loss 17160897

      Relevant External Links for TNFAIP8L1 Gene

      HapMap Linkage Disequilibrium report
      TNFAIP8L1

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFAIP8L1 Gene

      Disorders for TNFAIP8L1 Gene

      No disorders were found for TNFAIP8L1 Gene.

      No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TNFAIP8L1 Gene

      Publications for TNFAIP8L1 Gene

      1. The expression of TIPE1 in murine tissues and human cell lines. (PMID: 21600655) Cui J. … Liu S. (Mol. Immunol. 2011) 3 4
      2. Tnfaip8 l1/Oxi-beta binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model. (PMID: 24444419) Ha J.Y. … Son J.H. (J. Neurochem. 2014) 3 4
      3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
      4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
      5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

      Products for TNFAIP8L1 Gene

      • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
      • Pathway & Disease-focused RT² Profiler PCR Arrays
        • Molecular Toxicology PathwayFinder 384HT in human,mouse,rat
      • QIAGEN qRT-PCR Assays for microRNAs that regulate TNFAIP8L1
        • QuantiTect SYBR Green Assays in human,mouse,rat
        • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
        • QuantiFast Probe-based Assays in human,mouse,rat
        • Predesigned siRNA for gene silencing in human,mouse,rat for TNFAIP8L1
        • Block miRNA regulation of TNFAIP8L1 using miScript Target Protectors

        Sources for TNFAIP8L1 Gene

        Back to Top

        Content