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TNFAIP8L1 Gene

protein-coding   GIFtS: 43
GCID: GC19P004639

Tumor Necrosis Factor, Alpha-Induced Protein 8-Like 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor, Alpha-Induced Protein 8-Like 11 2
TNF Alpha-Induced Protein 8-Like Protein 12 3
TNFAIP8-Like Protein 12 3
TIPE12
Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 12
Tumor Necrosis Factor, Alpha-Induced Protein 8-Like Protein 12

External Ids:    HGNC: 282791   Entrez Gene: 1262822   Ensembl: ENSG000001853617   UniProtKB: Q8WVP53   

Export aliases for TNFAIP8L1 gene to outside databases

Previous GC identifers: GC19P004591 GC19P004400


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TNFAIP8L1 Gene:
TNFAIP8L1 (tumor necrosis factor, alpha-induced protein 8-like 1) is a protein-coding gene. An important paralog of this gene is TNFAIP8.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFAIP8L1 gene promoter:
         USF1   Sox5   SRY   CP2   USF-1   FOXO1a   NF-Y   Ik-1   FOXO1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFAIP8L1 promoter sequence
   Search Chromatin IP Primers for TNFAIP8L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFAIP8L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TNFAIP8L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFAIP8L1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P004639:  view genomic region     (about GC identifiers)

Start:
4,639,527 bp from pter      End:
4,655,580 bp from pter
Size:
16,054 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TP8L1_HUMAN, Q8WVP5 (See protein sequence)
Recommended Name: Tumor necrosis factor alpha-induced protein 8-like protein 1  
Size: 186 amino acids; 20827 Da
Secondary accessions: D6W627

Explore the universe of human proteins at neXtProt for TNFAIP8L1: NX_Q8WVP5

Explore proteomics data for TNFAIP8L1 at MOPED


See TNFAIP8L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001161414.1  NP_689575.2  

ENSEMBL proteins: 
 ENSP00000331827   ENSP00000444215  

TNFAIP8L1 Human Recombinant Protein Products:

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antibodies-online proteins for TNFAIP8L1 (4 products) 

 
antibodies-online peptides for TNFAIP8L1

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR008477 DUF758

Graphical View of Domain Structure for InterPro Entry Q8WVP5

ProtoNet protein and cluster: Q8WVP5

UniProtKB/Swiss-Prot: TP8L1_HUMAN, Q8WVP5
Similarity: Belongs to the TNFAIP8 family


Find genes that share domains with TNFAIP8L1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for TNFAIP8L1:
 Increased gamma-H2AX phosphory 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for TNFAIP8L1

miRNA
Products:
    
miRTarBase miRNAs that target TNFAIP8L1:
hsa-mir-484 (MIRT042335)

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Search for qRT-PCR Assays for microRNAs that regulate TNFAIP8L1
SwitchGear 3'UTR luciferase reporter plasmidTNFAIP8L1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for TNFAIP8L1
Predesigned siRNA for gene silencing in human, mouse, rat TNFAIP8L1

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GenScript: all cDNA clones in your preferred vector (see all 2): TNFAIP8L1 (NM_152362)
Sino Biological Human cDNA Clone for TNFAIP8L1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFAIP8L1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFAIP8L1

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP8L1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol1
extracellular1
mitochondrion1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including TNFAIP8L1: 
          Molecular Toxicology PathwayFinder 384HT in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for TNFAIP8L1

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

4 Interacting proteins for TNFAIP8L1 (Q8WVP52, 3 ENSP000003318274) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
DVL3Q929973, ENSP000003160544I2D: score=2 STRING: ENSP00000316054
PAICSENSP000003825954STRING: ENSP00000382595
--Q9UG073, 2MINT-68387 I2D: score=1 
--Q9UG073, 2MINT-68387 I2D: score=1 
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TNFAIP8L1 (TP8L1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TNFAIP8L1 gene (2 alternative transcripts): 
NM_001167942.1  NM_152362.2  

Unigene Cluster for TNFAIP8L1:

Tumor necrosis factor, alpha-induced protein 8-like 1
Hs.465643  [show with all ESTs]
Unigene Representative Sequence: NM_001167942
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000327473(uc002max.3) ENST00000598107 ENST00000536716(uc021une.1)

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidTNFAIP8L1 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for TNFAIP8L1
Predesigned siRNA for gene silencing in human, mouse, rat TNFAIP8L1
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GenScript: all cDNA clones in your preferred vector (see all 2): TNFAIP8L1 (NM_152362)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFAIP8L1
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for TNFAIP8L1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNFAIP8L1
  QuantiTect SYBR Green Assays in human, mouse, rat TNFAIP8L1
  QuantiFast Probe-based Assays in human, mouse, rat TNFAIP8L1

Additional mRNA sequence: 

AK024161.1 AK097251.1 AK098427.1 BC017672.1 BC044250.1 

8 DOTS entries:

DT.442505  DT.108079  DT.99983748  DT.40228324  DT.91827315  DT.100001343  DT.95328899  DT.92035316 

Selected AceView cDNA sequences (see all 117):

CA313841 BQ710277 BM701317 BM982249 AU121716 BG941203 AW299835 BU931103 
BQ021917 BQ278028 AA312006 BQ277936 AI674633 BX282702 BF971492 BF970674 
AA732803 BQ711766 BX952707 BX462906 AW592370 AI400033 AI123955 BG336893 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TNFAIP8L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TNFAIP8L1 Expression
About this image


TNFAIP8L1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Liver (Hepatobiliary System)
         Perivenous Hepatocytes Liver Lobule
 
 Heart (Cardiovascular System)
TNFAIP8L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TNFAIP8L1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.465643
    Pathway & Disease-focused RT2 Profiler PCR Array including TNFAIP8L1: 
          Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for TNFAIP8L1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNFAIP8L1
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QuantiFast Probe-based Assays in human, mouse, rat TNFAIP8L1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP8L1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TNFAIP8L1 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tnfaip8l11 , 5 tumor necrosis factor, alpha-induced protein 8-like more1, 5 81(n)1
81.72(a)1
  17 (29.19 cM)5
664431  NM_025566.31  NP_079842.21 
 561624775 
chicken
(Gallus gallus)
Aves TNFAIP8L11 tumor necrosis factor, alpha-induced protein 8-like more 74.55(n)
69.89(a)
  420162  NM_001006343.1  NP_001006343.1 
zebrafish
(Danio rerio)
Actinopterygii zgc553312 hypothetical protein MGC55331 80.19(n)   393303  BC052765.1 
fruit fly
(Drosophila melanogaster)
Insecta CG40916
--
30(a)
1 → many
2R(19586469-19589924)


ENSEMBL Gene Tree for TNFAIP8L1 (if available)
TreeFam Gene Tree for TNFAIP8L1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TNFAIP8L1 gene
TNFAIP82  TNFAIP8L22  TNFAIP8L32  
3 SIMAP similar genes for TNFAIP8L1 using alignment to 1 protein entry:     TP8L1_HUMAN:
TNFAIP8    TNFAIP8L3    TNFAIP8L2

Find genes that share paralogs with TNFAIP8L1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TNFAIP8L1 (see all 355)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs735337881,2
C,F--4397685(+) TCTGGG/TGTTCC 1 -- us2k12Minor allele frequency- T:0.04WA 120
rs1442199251,2
--4637642(+) AAATGA/TAATAA 1 -- us2k10--------
rs1460592981,2
--4637697(+) GTCCAG/TGCTGG 1 -- us2k10--------
rs1399933221,2
--4637749(+) CTGGGA/TTCAAG 1 -- us2k10--------
rs1434415661,2
C--4637800(+) GGCGTA/GCACCA 1 -- us2k10--------
rs1836561411,2
--4637898(+) TGCCGC/TGATCT 1 -- us2k10--------
rs1892519581,2
--4637958(+) AGCCTC/TCCGAG 1 -- us2k10--------
rs81004681,2
C,F--4637994(+) ccacgC/Accagc 1 -- us2k18Minor allele frequency- A:0.33NA WA CSA 15
rs3773493191,2
C--4638003(+) AGCTA-/TTTTTT 1 -- us2k10--------
rs2011790711,2
--4638016(+) TTTTG-/TATGTTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for TNFAIP8L1 (4639527 - 4655580 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for TNFAIP8L1 (see all 11):    About this table    
Variant IDTypeSubtypePubMed ID
nsv910847CNV Loss21882294
nsv428361CNV Loss18775914
dgv3681n71CNV Loss21882294
nsv526746CNV Loss19592680
dgv3680n71CNV Loss21882294
nsv833721CNV Loss17160897
dgv3678n71CNV Loss21882294
nsv910849CNV Loss21882294
nsv910856CNV Loss21882294
nsv910848CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TNFAIP8L1
DNA2.0 Custom Variant and Variant Library Synthesis for TNFAIP8L1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TNFAIP8L1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TNFAIP8L1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  2. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (PLoS ONE 2012)
  3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  5. The expression of TIPE1 in murine tissues and human cell lines. (PubMed id 21600655)1 Cui J....Liu S. (Mol. Immunol. 2011)
  6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 126282 HGNC: 28279 AceView: MGC17791 Ensembl:ENSG00000185361 euGenes: HUgn126282
ECgene: TNFAIP8L1 H-InvDB: TNFAIP8L1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TNFAIP8L1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFAIP8L1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TNFAIP8L1 gene:
Search GeneIP for patents involving TNFAIP8L1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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