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Aliases for TNFAIP8L1 Gene

Aliases for TNFAIP8L1 Gene

  • TNF Alpha Induced Protein 8 Like 1 2 3 5
  • Tumor Necrosis Factor, Alpha-Induced Protein 8-Like 1 2 3
  • TNF Alpha-Induced Protein 8-Like Protein 1 3 4
  • Oxidative Stress-Regulated Gene-Beta 3 4
  • TNFAIP8-Like Protein 1 3 4
  • Oxy-Beta 3 4
  • TIPE1 3 4
  • Tumor Necrosis Factor, Alpha-Induced Protein 8-Like Protein 1 3
  • Tumor Necrosis Factor, Alpha Induced Protein 8 Like 1 3

External Ids for TNFAIP8L1 Gene

Previous GeneCards Identifiers for TNFAIP8L1 Gene

  • GC19P004591
  • GC19P004400

Summaries for TNFAIP8L1 Gene

GeneCards Summary for TNFAIP8L1 Gene

TNFAIP8L1 (TNF Alpha Induced Protein 8 Like 1) is a Protein Coding gene. An important paralog of this gene is TNFAIP8.

UniProtKB/Swiss-Prot for TNFAIP8L1 Gene

  • Acts as a negative regulator of mTOR activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFAIP8L1 Gene

Genomics for TNFAIP8L1 Gene

Regulatory Elements for TNFAIP8L1 Gene

Enhancers for TNFAIP8L1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TNFAIP8L1 on UCSC Golden Path with GeneCards custom track

Promoters for TNFAIP8L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNFAIP8L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNFAIP8L1 Gene

4,639,514 bp from pter
4,655,568 bp from pter
16,055 bases
Plus strand

Genomic View for TNFAIP8L1 Gene

Genes around TNFAIP8L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFAIP8L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFAIP8L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP8L1 Gene

Proteins for TNFAIP8L1 Gene

  • Protein details for TNFAIP8L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor alpha-induced protein 8-like protein 1
    Protein Accession:
    Secondary Accessions:
    • D6W627

    Protein attributes for TNFAIP8L1 Gene

    186 amino acids
    Molecular mass:
    20827 Da
    Quaternary structure:
    • Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.

neXtProt entry for TNFAIP8L1 Gene

Proteomics data for TNFAIP8L1 Gene at MOPED

Post-translational modifications for TNFAIP8L1 Gene

No Post-translational modifications

Other Protein References for TNFAIP8L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFAIP8L1 Gene

Domains & Families for TNFAIP8L1 Gene

Protein Domains for TNFAIP8L1 Gene


Suggested Antigen Peptide Sequences for TNFAIP8L1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TNFAIP8 family.
  • Belongs to the TNFAIP8 family.
genes like me logo Genes that share domains with TNFAIP8L1: view

No data available for Gene Families for TNFAIP8L1 Gene

Function for TNFAIP8L1 Gene

Molecular function for TNFAIP8L1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of mTOR activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated by oxidative stress (OS) at both transcriptional and translational levels.

Phenotypes for TNFAIP8L1 Gene

genes like me logo Genes that share phenotypes with TNFAIP8L1: view

Animal Model Products

CRISPR Products

miRNA for TNFAIP8L1 Gene

miRTarBase miRNAs that target TNFAIP8L1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFAIP8L1 Gene

Localization for TNFAIP8L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFAIP8L1 Gene


Subcellular locations from

Jensen Localization Image for TNFAIP8L1 Gene COMPARTMENTS Subcellular localization image for TNFAIP8L1 gene
Compartment Confidence
cytosol 1
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for TNFAIP8L1 Gene

Pathways & Interactions for TNFAIP8L1 Gene

SuperPathways for TNFAIP8L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TNFAIP8L1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TNFAIP8L1 Gene

Drugs & Compounds for TNFAIP8L1 Gene

No Compound Related Data Available

Transcripts for TNFAIP8L1 Gene

Unigene Clusters for TNFAIP8L1 Gene

Tumor necrosis factor, alpha-induced protein 8-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP8L1 Gene

No ASD Table

Relevant External Links for TNFAIP8L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFAIP8L1 Gene

mRNA expression in normal human tissues for TNFAIP8L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFAIP8L1 Gene

This gene is overexpressed in Colon - Sigmoid (x4.3).

Protein differential expression in normal tissues from HIPED for TNFAIP8L1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.0) and Bone (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFAIP8L1 Gene

SOURCE GeneReport for Unigene cluster for TNFAIP8L1 Gene Hs.465643

mRNA Expression by UniProt/SwissProt for TNFAIP8L1 Gene

Tissue specificity: High expression detected in most carcinoma cell lines, especially in cells transformed with virus genomes.
genes like me logo Genes that share expression patterns with TNFAIP8L1: view

Protein tissue co-expression partners for TNFAIP8L1 Gene

Primer Products

Orthologs for TNFAIP8L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNFAIP8L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNFAIP8L1 35
  • 87.46 (n)
  • 84.41 (a)
  • 84 (a)
(Canis familiaris)
Mammalia TNFAIP8L1 35
  • 89.96 (n)
  • 89.78 (a)
  • 51 (a)
(Mus musculus)
Mammalia Tnfaip8l1 35
  • 81 (n)
  • 81.72 (a)
Tnfaip8l1 16
Tnfaip8l1 36
  • 82 (a)
(Pan troglodytes)
Mammalia TNFAIP8L1 35
  • 100 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tnfaip8l1 35
  • 78.67 (n)
  • 77.96 (a)
(Monodelphis domestica)
Mammalia TNFAIP8L1 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia TNFAIP8L1 36
  • 68 (a)
(Gallus gallus)
Aves TNFAIP8L1 35
  • 74.55 (n)
  • 69.89 (a)
  • 70 (a)
(Danio rerio)
Actinopterygii tnfaip8l1 35
  • 70.07 (n)
  • 68.28 (a)
zgc55331 35
tnfaip8 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4091 36
  • 30 (a)
Species with no ortholog for TNFAIP8L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFAIP8L1 Gene

Gene Tree for TNFAIP8L1 (if available)
Gene Tree for TNFAIP8L1 (if available)

Paralogs for TNFAIP8L1 Gene

Paralogs for TNFAIP8L1 Gene

(3) SIMAP similar genes for TNFAIP8L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNFAIP8L1: view

Variants for TNFAIP8L1 Gene

Sequence variations from dbSNP and Humsavar for TNFAIP8L1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs17851549 - 4,652,222(+) GGCCG(C/T)CGGGC reference, missense
rs12976605 -- 4,647,633(+) ttttt(C/T)ccttt intron-variant
rs8100468 -- 4,637,982(+) ccacg(A/C)ccagc upstream-variant-2KB
rs66616337 -- 4,644,694(+) TGCCC(C/T)CCAGG intron-variant
rs16992471 -- 4,640,283(+) GTTTG(G/T)CCAGG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TNFAIP8L1 Gene

Variant ID Type Subtype PubMed ID
dgv3678n71 CNV Loss 21882294
nsv428361 CNV Loss 18775914
dgv3679n71 CNV Loss 21882294
nsv910847 CNV Loss 21882294
nsv526746 CNV Loss 19592680
nsv910848 CNV Loss 21882294
nsv910849 CNV Loss 21882294
dgv3680n71 CNV Loss 21882294
dgv3681n71 CNV Loss 21882294
nsv910856 CNV Loss 21882294
nsv833721 CNV Loss 17160897

Variation tolerance for TNFAIP8L1 Gene

Gene Damage Index Score: 0.28; 6.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TNFAIP8L1 Gene

Disorders for TNFAIP8L1 Gene

Relevant External Links for TNFAIP8L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TNFAIP8L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFAIP8L1 Gene

Publications for TNFAIP8L1 Gene

  1. Tnfaip8 l1/Oxi-beta binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model. (PMID: 24444419) Ha J.Y. … Son J.H. (J. Neurochem. 2014) 3 4 67
  2. The TIPE (TNFAIP8) family in inflammation, immunity, and cancer. (PMID: 21924498) Lou Y. … Liu S. (Mol. Immunol. 2011) 2 3
  3. TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells. (PMID: 25043299) Zhang Z. … Ma C. (Oncogene 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Tnfaip8l1/Oxi-I^ binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model. (PMID: 24372178) Ha J.Y. … Son J.H. (J. Neurochem. 2013) 3

Products for TNFAIP8L1 Gene

Sources for TNFAIP8L1 Gene