Aliases for TNFAIP8 Gene
Aliases for TNFAIP8 Gene
External Ids for TNFAIP8 Gene
- HGNC: 17260
- Entrez Gene: 25816
- Ensembl: ENSG00000145779
- OMIM: 612111
- UniProtKB: O95379
Previous GeneCards Identifiers for TNFAIP8 Gene
- GC00U914375
- GC05P118768
- GC05P118719
- GC05P118604
- GC05P113799
Summaries for TNFAIP8 Gene
GeneCards Summary for TNFAIP8 Gene
TNFAIP8 (TNF Alpha Induced Protein 8) is a Protein Coding gene. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is TNFAIP8L2.
UniProtKB/Swiss-Prot for TNFAIP8 Gene
-
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFAIP8 Gene
Genomics for TNFAIP8 Gene
Regulatory Elements for TNFAIP8 Gene
Enhancers for TNFAIP8 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around TNFAIP8 on UCSC Golden Path with GeneCards custom track
Promoters for TNFAIP8 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around TNFAIP8 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TNFAIP8 gene promoter:
Regulatory Element Products
Genomic Location for TNFAIP8 Gene
- Chromosome:
- 5
- Start:
- 119,268,692 bp from pter
- End:
- 119,399,688 bp from pter
- Size:
- 130,997 bases
- Orientation:
- Plus strand
Genomic View for TNFAIP8 Gene
Genes around TNFAIP8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q23.1 by Ensembl
- 5q23.1 by Entrez Gene
- 5q23.1 by HGNC
TNFAIP8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TNFAIP8 Gene
Proteins for TNFAIP8 Gene
-
Protein details for TNFAIP8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95379-TFIP8_HUMAN
- Recommended name:
- Tumor necrosis factor alpha-induced protein 8
- Protein Accession:
- O95379
- B3KMH1
- B3KMI2
- B7Z713
- Q9P1Q1
- Q9UER5
- Q9UP47
Protein attributes for TNFAIP8 Gene
- Size:
- 198 amino acids
- Molecular mass:
- 23003 Da
- Quaternary structure:
- No Data Available
Protein Expression for TNFAIP8 Gene
Post-translational modifications for TNFAIP8 Gene
Other Protein References for TNFAIP8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for TNFAIP8
- Invitrogen Antibodies for TNFAIP8
- antibodies-online Antibodies for TNFAIP8: See all 43
- GeneTex TNFAIP8 antibody for TNFAIP8
-
Santa Cruz Biotechnology (SCBT) Antibodies for TNFAIP8
Protein Products
-
OriGene Purified Proteins for TNFAIP8
- Search Origene for MassSpec and Protein Over-expression Lysates for TNFAIP8
- Origene Custom Protein Services for TNFAIP8
- Sino Biological Recombinant Proteins for TNFAIP8
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for TNFAIP8
- antibodies-online Proteins for TNFAIP8: See all 13
- Search antibodies-online for peptides
- GeneTex TNF alpha IP8 Protein (GTX111940-pro) for TNFAIP8
Assay Products
No data available for DME Specific Peptides for TNFAIP8 Gene
Domains & Families for TNFAIP8 Gene
Suggested Antigen Peptide Sequences for TNFAIP8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O95379- Family:
-
- Belongs to the TNFAIP8 family.
No data available for Gene Families for TNFAIP8 Gene
Function for TNFAIP8 Gene
Molecular function for TNFAIP8 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
- UniProtKB/Swiss-Prot Induction:
- By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.
Phenotypes for TNFAIP8 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for TNFAIP8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TNFAIP8 gene
- Search ViGene Biosciences for TNFAIP8
CRISPR Products
-
OriGene CRISPR knockouts for TNFAIP8
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNFAIP8
- GenScript: Design CRISPR guide RNA sequences for TNFAIP8
miRNA for TNFAIP8 Gene
- miRTarBase miRNAs that target TNFAIP8
-
- hsa-mir-452-5p (MIRT053458)
- bta-mir-146a (MIRT053929)
- bta-mir-146b (MIRT053945)
- bta-mir-155 (MIRT053965)
- bta-mir-205 (MIRT054019)
- hsa-mir-574-5p (MIRT625206)
- hsa-mir-23c (MIRT625207)
- hsa-mir-23b-3p (MIRT625208)
- hsa-mir-23a-3p (MIRT625209)
- hsa-mir-130a-5p (MIRT625210)
- hsa-mir-6867-5p (MIRT625211)
- hsa-mir-223-5p (MIRT625212)
- hsa-mir-630 (MIRT625213)
- hsa-mir-4717-3p (MIRT625214)
- hsa-mir-147a (MIRT634981)
- hsa-mir-6818-5p (MIRT634982)
- hsa-mir-6769b-5p (MIRT652325)
- hsa-mir-6769a-5p (MIRT652326)
- hsa-mir-92a-2-5p (MIRT652327)
- hsa-mir-654-5p (MIRT652328)
- hsa-mir-541-3p (MIRT652329)
- hsa-mir-6787-3p (MIRT720773)
- hsa-mir-6884-3p (MIRT720774)
- hsa-mir-3614-3p (MIRT720775)
miRNA Products
- Search ViGene Biosciences for TNFAIP8
Clone Products
- OriGene clones in human for TNFAIP8
- OriGene ORF clones in human,mouse,rat for TNFAIP8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for TNFAIP8 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TNFAIP8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TNFAIP8 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFAIP8 Gene
Localization for TNFAIP8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TNFAIP8 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 3 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
No data available for Gene Ontology (GO) - Cellular Components for TNFAIP8 Gene
Pathways & Interactions for TNFAIP8 Gene
More details on SuperPathways for TNFAIP8
No Data Available
Interacting Proteins for TNFAIP8 Gene
Selected Interacting proteins:
O95379-TFIP8_HUMAN
ENSP00000421848
for TNFAIP8 Gene via
MINT
STRING
UniProtKB
I2D
No data available for Pathways by source and SIGNOR curated interactions for TNFAIP8 Gene
Transcripts for TNFAIP8 Gene
mRNA/cDNA for TNFAIP8 Gene
- (6) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (173) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TNFAIP8 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TNFAIP8
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNFAIP8
- GenScript: Design CRISPR guide RNA sequences for TNFAIP8
miRNA Products
- Search ViGene Biosciences for TNFAIP8
Clone Products
- OriGene clones in human for TNFAIP8
- OriGene ORF clones in human,mouse,rat for TNFAIP8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for TNFAIP8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Protoplasmic Astrocyte Cells Neocortex
-
Glial Cells
- Protoplasmic Astrocyte Cells Neocortex
-
Spleen (Hematopoietic System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for TNFAIP8 Gene
This gene is overexpressed in Whole Blood (x5.4).
This gene is overexpressed in Peripheral blood mononuclear cells (18.7), Lymph node (10.0), and Tlymphocyte (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNFAIP8 Gene
SOURCE GeneReport for Unigene cluster for TNFAIP8 Gene Hs.656274
mRNA Expression by UniProt/SwissProt for TNFAIP8 Gene
O95379-TFIP8_HUMAN
Tissue specificity:
Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for TNFAIP8
-
OriGene qPCR primer pairs and template standards for TNFAIP8
Orthologs for TNFAIP8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | TNFAIP8 35 |
|
||
| TNFAIP8 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | TNFAIP8 35 |
|
||
| TNFAIP8 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Tnfaip8 35 |
|
||
| Tnfaip8 16 |
|
||||
| Tnfaip8 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | TNFAIP8 35 |
|
||
| TNFAIP8 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Tnfaip8 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TNFAIP8 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TNFAIP8 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TNFAIP8 35 |
|
||
| TNFAIP8 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | TNFAIP8 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tnfaip8 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24156 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002997 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG4091 35 |
|
||
| CG4091 36 |
|
OneToMany |
- Species with no ortholog for TNFAIP8:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TNFAIP8 Gene
(3) SIMAP similar genes for TNFAIP8 Gene using alignment to 5 proteins:
Variants for TNFAIP8 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs3203922 | - | 119,393,258(+) | AATGT(C/G)TTTGA | reference, synonymous-codon | |
| rs11064 | -- | 119,393,693(+) | AGGGC(A/G)GTTGT | utr-variant-3-prime | |
| rs888768 | -- | 119,289,721(-) | TGTCA(C/G)AGGTG | intron-variant | |
| rs888769 | -- | 119,289,638(-) | AGCCA(C/T)GTACA | intron-variant | |
| rs888770 | -- | 119,280,512(+) | gcttt(G/T)ccctc | intron-variant |
Residual Variation Intolerance Score:
46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.35;
7.79% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TNFAIP8 Gene
- Human Gene Mutation Database (HGMD)
- TNFAIP8
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFAIP8 Gene
Disorders for TNFAIP8 Gene
Relevant External Links for TNFAIP8
No disorders were found for TNFAIP8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFAIP8 Gene
Publications for TNFAIP8 Gene
- Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein. (PMID: 10644768) Kumar D. … Kasid U. (J. Biol. Chem. 2000) 2 3 4 67
- Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells. (PMID: 14724590) Kumar D. … Kasid U. (Oncogene 2004) 3 23
- Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PMID: 10233894) Horrevoets A.J.G. … Pannekoek H. (Blood 1999) 2 3
- Expression of tumor necrosis factor I+-induced protein 8 is upregulated in human gastric cancer and regulates cell proliferation, invasion and migration. (PMID: 25936980) Li Y. … Guo X. (Mol Med Rep 2015) 3
- Variance of TNFAIP8 expression between tumor tissues and tumor-infiltrating CD4+ and CD8+ T cells in non-small cell lung cancer. (PMID: 24136748) Wang L. … Men X. (Tumour Biol. 2014) 3
Products for TNFAIP8 Gene
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- Browse R&D Systems for biochemical assays
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- Custom Antibody Services
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- Custom Assay Services
- OriGene Purified Proteins for TNFAIP8
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- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for TNFAIP8
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- OriGene qPCR primer pairs for TNFAIP8
- OriGene qPCR primer pairs and template standards for TNFAIP8
- OriGene CRISPR knockouts for TNFAIP8
- OriGene clones in human for TNFAIP8
- OriGene ORF clones in human,mouse,rat for TNFAIP8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for TNFAIP8
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- GenScript: Design CRISPR guide RNA sequences for TNFAIP8
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- Novus Biologicals Antibodies for TNFAIP8
- Novus Biologicals proteins and lysates for TNFAIP8
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for TNFAIP8
- antibodies-online Antibodies for TNFAIP8: See all 43
- Search antibodies-online for kits
- antibodies-online Proteins for TNFAIP8: See all 13
- Search antibodies-online for peptides
- GeneTex TNFAIP8 antibody for TNFAIP8
- GeneTex TNF alpha IP8 Protein (GTX111940-pro) for TNFAIP8
- ViGene Biosciences adenoviral particle packaged cDNA for TNFAIP8 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TNFAIP8 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TNFAIP8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TNFAIP8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TNFAIP8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TNFAIP8 gene
- Search ViGene Biosciences for TNFAIP8
- Search ViGene Biosciences for TNFAIP8
- Santa Cruz Biotechnology (SCBT) Antibodies for TNFAIP8
- Search Santa Cruz Biotechnology (SCBT) for TNFAIP8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TNFAIP8
Sources for TNFAIP8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon