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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TNFAIP8 Gene

protein-coding GIFtS: 53
GCID: GC05P118604

Tumor Necrosis Factor, Alpha-Induced Protein 8

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Tumor Necrosis Factor, Alpha-Induced Protein 8¹ ²		TNF Alpha-Induced Protein 8² ³
Head And Neck Tumor And Metastasis-Related Protein² ³		TNF-Induced Protein GG2-1² ³
MDC-3.13² ³		SCCS2² ⁵
NDED² ³		GG2-1²
SCC-S2² ³		Tumor Necrosis Factor Alpha-Induced Protein 8²
NF-Kappa-B-Inducible DED-Containing Protein² ³

External Ids:	HGNC: 17260¹	Entrez Gene: 25816²	Ensembl: ENSG00000145779⁷	OMIM: 612111⁵	UniProtKB: O95379³

Export aliases for TNFAIP8 gene to outside databases

Previous GC identifers: GC00U914375 GC05P118768 GC05P118719 GC05P113799

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TNFAIP8 Gene:

TNFAIP8 (tumor necrosis factor, alpha-induced protein 8) is a protein-coding gene. Diseases associated with TNFAIP8 include non-hodgkin lymphoma, and hodgkin's lymphoma. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is TNFAIP8L2.

UniProtKB/Swiss-Prot: TFIP8_HUMAN, O95379

Function: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the

TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently

resulting in inhibition of BID cleavage and caspase-3 activation

Gene Wiki entry for TNFAIP8 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NT_034772.6 NC_018916.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNFAIP8 gene promoter:
HOXA9B HOXA9 Elk-1 FOXD3 NF-kappaB Meis-1b Egr-2 ARP-1 NF-kappaB1 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TNFAIP8 promoter sequence

Search SABiosciences Chromatin IP Primers for TNFAIP8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFAIP8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.1 Ensembl cytogenetic band: 5q23.1 HGNC cytogenetic band: 5q23.1

TNFAIP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFAIP8 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P118604: view genomic region (about GC identifiers)

Start:	118,604,387 bp from pter	End:	118,735,383 bp from pter
Size:	130,997 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TFIP8_HUMAN, O95379 (See protein sequence)

Recommended Name: Tumor necrosis factor alpha-induced protein 8

Size: 198 amino acids; 23003 Da

Subcellular location: Cytoplasm

Developmental stage: Expressed at high levels in the fetal liver, lung and kidney

Secondary accessions: B3KMH1 B3KMI2 Q9P1Q1 Q9UER5 Q9UP47

Alternative splicing: 3 isoforms: O95379-1 O95379-2 O95379-3

Explore the universe of human proteins at neXtProt for TNFAIP8: NX_O95379

Explore proteomics data for TNFAIP8 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_O95379

TNFAIP8 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_001071122.1 NP_055165.2

ENSEMBL proteins:

ENSP00000274456 ENSP00000429432 ENSP00000427424 ENSP00000422245 ENSP00000421848

ENSP00000427160 ENSP00000408534

Human Recombinant Protein Products for TNFAIP8:

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	Novus Biologicals TNFAIP8 Proteins Novus Biologicals TNFAIP8 Lysates
	Sino Biological Recombinant Protein for TNFAIP8 Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	14724590

TNFAIP8 for ontologies About GeneDecksing

TNFAIP8 Antibody Products:

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	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR008477 DUF758

Graphical View of Domain Structure for InterPro Entry O95379

ProtoNet protein and cluster: O95379

UniProtKB/Swiss-Prot: TFIP8_HUMAN, O95379

Similarity: Belongs to the TNFAIP8 family

TNFAIP8 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TFIP8_HUMAN, O95379

Function: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the

TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently

resulting in inhibition of BID cleavage and caspase-3 activation

Induction: By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP	10644768

TNFAIP8 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for TNFAIP8

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNFAIP8

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFAIP8

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFAIP8

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFAIP8
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFAIP8 (see all 23):
		hsa-miR-4291 hsa-miR-495 hsa-miR-607 hsa-miR-1271 hsa-miR-9 hsa-miR-7-1* hsa-miR-96 hsa-miR-761

		SwitchGear 3'UTR luciferase reporter plasmid: TNFAIP8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): TNFAIP8 (NM_014350)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TNFAIP8
		Search LifeMap BioReagents cell lines for TNFAIP8

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP8

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TNFAIP8

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5/7 Interacting proteins for TNFAIP8 (O95379^{2, 3} ENSP00000408534⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MED4	Q9NPJ6²^,³, ENSP00000258648⁴	MINT-66580 I2D: score=5 STRING: ENSP00000258648
PTP4A1	Q93096³, ENSP00000359685⁴	I2D: score=2 STRING: ENSP00000359685
PTP4A2	Q12974³, ENSP00000344909⁴	I2D: score=2 STRING: ENSP00000344909
FLNC	Q14315³, ENSP00000327145⁴	I2D: score=1 STRING: ENSP00000327145
MAGEC2	Q9UBF1³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0043066	negative regulation of apoptotic process	TAS	10644768
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	10644768

TNFAIP8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNFAIP8 (TFIP8)

Search CenterWatch for drugs/clinical trials and news about TNFAIP8 / TFIP8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNFAIP8 gene (2 alternative transcripts):

NM_001077654.1 NM_014350.2

Unigene Cluster for TNFAIP8:

Tumor necrosis factor, alpha-induced protein 8

Hs.656274 [show with all ESTs]

Unigene Representative Sequence: AK097284

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000274456 ENST00000388882 ENST00000513374 ENST00000504771(uc003ksi.3)

ENST00000503646 ENST00000504642 ENST00000415806(uc003ksf.1 uc003ksg.3 uc011cwf.2)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFAIP8
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFAIP8 (see all 23):
		hsa-miR-4291 hsa-miR-495 hsa-miR-607 hsa-miR-1271 hsa-miR-9 hsa-miR-7-1* hsa-miR-96 hsa-miR-761

		SwitchGear 3'UTR luciferase reporter plasmid: TNFAIP8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Primer Products:		OriGene qPCR primer pairs and template standards for TNFAIP8 OriGene qSTAR qPCR primer pairs in human, mouse for TNFAIP8
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TNFAIP8
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFAIP8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFAIP8

Additional mRNA sequence:

AF070671.1 AF098933.1 AF098934.1 AF099935.1 AF099936.1 AK001850.1 AK001931.1 AK097284.1

AK097884.1 AK301281.1 BC005352.1 BC007014.1 CR457137.1

13 DOTS entries:

DT.95374378 DT.213227 DT.95374380 DT.100023100 DT.120878808 DT.100023099 DT.100803903 DT.75151940

DT.120878814 DT.95111430 DT.97801986 DT.100712480 DT.91976978

24/173 AceView cDNA sequences (see all 173):

AI978922 AI760403 BU674396 BP379054 AK097884 AI423860 AK001931 AA411104

BG678510 BI819214 N50762 BU753619 AA868334 AF098934 BQ772421 BG178783

CR615131 CR611795 CR615621 AU135377 AL527566 BM979655 AK001850 AA644572

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNFAIP8 expression in normal human tissues (normalized intensities) TNFAIP8 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGCATAAAAA

About this image

TNFAIP8 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/1 selected tissues (see all 1) fully expand


Gut Tube (Gastrointestinal Tract)
Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

See TNFAIP8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFAIP8

SOURCE GeneReport for Unigene cluster: Hs.656274

UniProtKB/Swiss-Prot: TFIP8_HUMAN, O95379

Tissue specificity: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta.

Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells.

Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Array including TNFAIP8:

Apoptosis 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TNFAIP8 gene from 5/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tnfaip8^{1 , 5}	tumor necrosis factor, alpha-induced protein 8^{1, 5}	85.86(n)¹ 93.43(a)¹		18 (27.18 cM)⁵ 106869¹ NM_134131.2¹ NP_598892.2¹ 49979427⁵
chicken (Gallus gallus)	Aves	TNFAIP8¹	tumor necrosis factor, alpha-induced protein 8	82.62(n) 89.89(a)		427384 NM_001031441.1 NP_001026612.1
lizard (Anolis carolinensis)	Reptilia	TNFAIP8⁶	tumor necrosis factor, alpha-induced protein 8	87(a)	1 ↔ 1	GL343193.1(10489542-10513205)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24156²	Xenopus laevis transcribed sequence with moderate similarity more	78.06(n)		BX849289.1
fruit fly (Drosophila melanogaster)	Insecta	CG4091¹	CG4091	52.48(n) 41.49(a)		37751 NM_166622.1 NP_726358.2

ENSEMBL Gene Tree for TNFAIP8 (if available)
TreeFam Gene Tree for TNFAIP8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TNFAIP8 gene

TNFAIP8L2² TNFAIP8L3² TNFAIP8L1²

3 SIMAP similar genes for TNFAIP8 using alignment to 5 protein entries: TFIP8_HUMAN (see all proteins):

TNFAIP8L3 TNFAIP8L1 TNFAIP8L2

TNFAIP8 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186259344^1,2		--	118602501(+)	`AAAACA/GAGTCT`	1	--	us2k¹		0	--	--	--	--
rs190984047^1,2		--	118602583(+)	`CACAGG/TCCTTG`	1	--	us2k¹		0	--	--	--	--
rs146530686^1,2		--	118602593(+)	`GGTTCA/GTGGTT`	1	--	us2k¹		0	--	--	--	--
rs79947114^1,2	C	--	118602596(+)	`TCGTGG/ATTCAG`	1	--	us2k¹		3		CSA WA EA	240
rs75891205^1,2	C,F	--	118602619(+)	`TCACAC/GTTTGA`	1	--	us2k¹		1		EA	120
rs1394625^1,2	C,F	--	118602669(+)	`TGTGAT/CTAGAT`	1	--	us2k¹		2		NA	122
rs183232796^1,2		--	118602696(+)	`ATCCAA/GGATAA`	1	--	us2k¹		0	--	--	--	--
rs187900514^1,2		--	118602722(+)	`GCATCA/CATCTT`	1	--	us2k¹		0	--	--	--	--
rs35903068^1,2	C,F	--	118602770(+)	`CATGAC/TCGAAT`	1	--	us2k¹		3		NA	6
rs1394626^1,2	C,F,A,H	--	118602909(+)	`TTTCAA/CTATTT`	1	--	us2k¹		5		NS EA WA	536

HapMap Linkage Disequilibrium report for TNFAIP8 (118604387 - 118735383 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for TNFAIP8: About this table

Variant ID	Type	Subtype	PubMed ID
esv24760	CNV	Loss	19812545
nsv882775	CNV	Gain	21882294
dgv1846e1	CNV	Complex	17122850

Human Gene Mutation Database (HGMD): TNFAIP8

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing TNFAIP8

DNA2.0 Custom Variant and Variant Library Synthesis for TNFAIP8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 612111 OMIM disorders: --

6 diseases for TNFAIP8: About MalaCards

non-hodgkin lymphoma hodgkin's lymphoma colon cancer thyroiditis

lung cancer endotheliitis

TNFAIP8 for disorders About GeneDecksing

Genetic Association Database (GAD): TNFAIP8

Export disorders for TNFAIP8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TNFAIP8 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with TNFAIP8)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein. (PubMed id 10644768)^{1, 2, 3} Kumar D.... Kasid U. (2000)
Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PubMed id 10233894)^{1, 2, 3} Horrevoets A.J.G.... Pannekoek H. (1999)
Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells. (PubMed id 14724590)^{1, 2, 9} Kumar D.... Kasid U. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Functional variants in TNFAIP8 associated with cervica l cancer susceptibility and clinical outcomes. (PubMed id 23299407)¹ Shi T.Y....Wei Q. (2013)
The significance of TNFAIP8 in prostate cancer respons e to radiation and docetaxel and disease recurrence. (PubMed id 23280553)¹ Zhang C....Kasid U.N. (2013)
Expression of tumor necrosis factor-alpha-induced prot ein 8 in pancreas tissues and its correlation with epithelial growth factor rece ptor levels. (PubMed id 22631659)¹ Liu K....Zhang D.Y. (2012)
SCC-S2 is overexpressed in colon cancers and regulates cell proliferation. (PubMed id 22886548)¹ Miao Z....Xu H. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Tumor necrosis factor-a induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control stud y. (PubMed id 22666399)¹ Zhang Y....Zhou X.Y. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 25816	HGNC: 17260	AceView: TNFAIP8	Ensembl:ENSG00000145779	euGenes: HUgn25816
ECgene: TNFAIP8	H-InvDB: TNFAIP8

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TNFAIP8	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFAIP8	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TNFAIP8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TNFAIP8 gene:
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GeneCards and IP:
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TNFAIP8 Gene

Tumor Necrosis Factor, Alpha-Induced Protein 8

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TNFAIP8 Gene

Tumor Necrosis Factor, Alpha-Induced Protein 8

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