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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFAIP8 Gene

protein-coding   GIFtS: 50
GCID: GC05P118604

tumor necrosis factor, alpha-induced protein 8

 Explore 3 diseases affiliated with
TNFAIP8 via our new
 Human Malady Compendium 
Biological research products
for TNFAIP8
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tumor Necrosis Factor, Alpha-Induced Protein 81 2     NF-Kappa-B-Inducible DED-Containing Protein2 3
MDC-3.131 2 3     TNF Alpha-Induced Protein 82 3
SCC-S21 2 3     TNF-Induced Protein GG2-12 3
GG2-11 2     SCCS22 5
Head And Neck Tumor And Metastasis-Related Protein2 3     Tumor Necrosis Factor Alpha-Induced Protein 82
NDED2 3     

External Ids:    HGNC: 172601   Entrez Gene: 258162   Ensembl: ENSG000001457797   OMIM: 6121115   UniProtKB: O953793   

Export aliases for TNFAIP8 gene to outside databases

Previous GC identifers: GC00U914375 GC05P118768 GC05P118719 GC05P113799


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TFIP8_HUMAN, O95379
Function: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the
TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting
in inhibition of BID cleavage and caspase-3 activation

Gene Wiki entry for TNFAIP8


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFAIP8 gene promoter:
         HOXA9B   HOXA9   Elk-1   FOXD3   NF-kappaB   Meis-1b   Egr-2   ARP-1   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TNFAIP8 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFAIP8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFAIP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.1   Ensembl cytogenetic band:  5q23.1   HGNC cytogenetic band: 5q23.1

TNFAIP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFAIP8 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P118604:  view genomic region     (about GC identifiers)

Start:
118,604,387 bp from pter      End:
118,730,294 bp from pter
Size:
125,908 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TFIP8_HUMAN, O95379 (See protein sequence)
Recommended Name: Tumor necrosis factor alpha-induced protein 8  
Size: 198 amino acids; 23003 Da
Subcellular location: Cytoplasm
Developmental stage: Expressed at high levels in the fetal liver, lung and kidney
Secondary accessions: B3KMH1 B3KMI2 Q9P1Q1 Q9UER5 Q9UP47
Alternative splicing: 3 isoforms:  O95379-1   O95379-2   O95379-3   

Explore the universe of human proteins at neXtProt for TNFAIP8: NX_O95379

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95379

  • TNFAIP8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001071122.1  NP_055165.2  

    ENSEMBL proteins: 
     ENSP00000274456   ENSP00000429432   ENSP00000427424   ENSP00000422245   ENSP00000421848  
     ENSP00000427160   ENSP00000408534  

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    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA14724590


    TNFAIP8 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TNFAIP8 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008477 DUF758

    Graphical View of Domain Structure for InterPro Entry O95379

    ProtoNet protein and cluster: O95379

    UniProtKB/Swiss-Prot: TFIP8_HUMAN, O95379
    Similarity: Belongs to the TNFAIP8 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TFIP8_HUMAN, O95379
    Function: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the
    TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting
    in inhibition of BID cleavage and caspase-3 activation
    Induction: By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP10644768


    TNFAIP8 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TNFAIP8

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/7 Interacting proteins for TNFAIP8 (O953792, 3 ENSP000004085344) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED4Q9NPJ62, 3, ENSP000002586484MINT-66580 I2D: score=5 STRING: ENSP00000258648
    PTP4A1Q930963, ENSP000003596854I2D: score=2 STRING: ENSP00000359685
    PTP4A2Q129743, ENSP000003449094I2D: score=2 STRING: ENSP00000344909
    FLNCQ143153, ENSP000003271454I2D: score=1 STRING: ENSP00000327145
    MAGEC2Q9UBF13I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019987negative regulation of anti-apoptosis ----
    GO:0043066negative regulation of apoptotic process TAS10644768
    GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP10644768


    TNFAIP8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFAIP8
    Search CenterWatch for drugs/clinical trials and news about TNFAIP8 / TFIP8 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNFAIP8 gene (2 alternative transcripts): 
    NM_001077654.1  NM_014350.2  

    Unigene Cluster for TNFAIP8:

    Tumor necrosis factor, alpha-induced protein 8
    Hs.656274  [show with all ESTs]
    Unigene Representative Sequence: AK097284
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274456 ENST00000388882 ENST00000513374 ENST00000504771(uc003ksi.3)
    ENST00000503646 ENST00000504642 ENST00000415806(uc003ksf.1 uc003ksg.3 uc011cwf.2)


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    hsa-miR-4291 hsa-miR-495 hsa-miR-607 hsa-miR-1271 hsa-miR-9 hsa-miR-7-1* hsa-miR-96 hsa-miR-761
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    Additional cDNA sequence: 

    AF070671.1 AF098933.1 AF098934.1 AF099935.1 AF099936.1 AK001850.1 AK001931.1 AK097284.1 
    AK097884.1 AK301281.1 BC005352.1 BC007014.1 CR457137.1 

    13 DOTS entries:

    DT.95374378  DT.213227  DT.95374380  DT.100023100  DT.120878808  DT.100023099  DT.100803903  DT.75151940 
    DT.120878814  DT.95111430  DT.97801986  DT.100712480  DT.91976978 

    24/173 AceView cDNA sequences (see all 173):

    BP379054 AK001931 AI760403 AI423860 AK097884 BU674396 AF098934 AI978922 
    AA868334 BG178783 BU753619 N50762 CR615131 AA411104 BI819214 BQ772421 
    BG678510 CR615621 AL527566 AU135377 AK001850 AI571143 BM979655 AI470390 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFAIP8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCATAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    TNFAIP8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TNFAIP8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFAIP8

    SOURCE GeneReport for Unigene cluster: Hs.656274

    UniProtKB/Swiss-Prot: TFIP8_HUMAN, O95379
    Tissue specificity: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta.
    Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed
    at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including TNFAIP8: 
              Apoptosis 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TNFAIP8 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfaip81 , 5 tumor necrosis factor, alpha-induced protein 81, 5 85.86(n)1
    93.43(a)1
      18 (27.18 cM)5
    1068691  NM_134131.21  NP_598892.21 
     499794275 
    chicken
    (Gallus gallus)
    Aves TNFAIP81 tumor necrosis factor, alpha-induced protein 8 82.62(n)
    89.89(a)
      427384  NM_001031441.1  NP_001026612.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNFAIP86
    --
    85(a)
    1 ↔ 1
    GL343193.1(10512609-10513205)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.241562 Xenopus laevis transcribed sequence with moderate similarity more 78.06(n)    BX849289.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG40911 CG4091 52.48(n)
    41.49(a)
      37751  NM_166622.1  NP_726358.2 


    ENSEMBL Gene Tree for TNFAIP8 (if available)
    TreeFam Gene Tree for TNFAIP8 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFAIP8 gene
    TNFAIP8L22  TNFAIP8L32  TNFAIP8L12  
    3 SIMAP similar genes for TNFAIP8 using alignment to 5 protein entries:     TFIP8_HUMAN (see all proteins):
    TNFAIP8L3    TNFAIP8L1    TNFAIP8L2

    TNFAIP8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2602 NCBI SNPs in TNFAIP8 are shown (see all 2602    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862593441,2
    --118602501(+) AAAACA/GAGTCT 1 -- us2k10--------
    rs1909840471,2
    --118602583(+) CACAGG/TCCTTG 1 -- us2k10--------
    rs1465306861,2
    --118602593(+) GGTTCA/GTGGTT 1 -- us2k10--------
    rs799471141,2
    --118602596(+) TCGTGG/ATTCAG 1 -- us2k13Minor allele frequency- A:0.13CSA WA EA 240
    rs758912051,2
    F,--118602619(+) TCACAC/GTTTGA 1 -- us2k11Minor allele frequency- G:0.08EA 120
    rs13946251,2
    C,--118602669(+) TGTGAT/CTAGAT 1 -- us2k12Minor allele frequency- C:0.07NA 122
    rs1832327961,2
    --118602696(+) ATCCAA/GGATAA 1 -- us2k10--------
    rs1879005141,2
    --118602722(+) GCATCA/CATCTT 1 -- us2k10--------
    rs359030681,2
    C,F,--118602770(+) CATGAC/TCGAAT 1 -- us2k13Minor allele frequency- T:0.33NA 6
    rs13946261,2
    C,F,A,H,--118602909(+) TTTCAA/CTATTT 1 -- us2k15Minor allele frequency- C:0.02NS EA WA 536

    HapMap Linkage Disequilibrium report for TNFAIP8 (118604387 - 118730294 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TNFAIP8
         2 CNVs: 64289 2599

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TNFAIP8 for disorders           About GeneDecksing

    OMIM gene information: 612111    OMIM disorders: --

    3 diseases for TNFAIP8:    About MalaCards
    nephropathy    lung cancer    thyroiditis


    Export disorders for TNFAIP8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFAIP8 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with TNFAIP8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein. (PubMed id 10644768)1, 2, 3 Kumar D.... Kasid U. (2000)
    2. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PubMed id 10233894)1, 2, 3 Horrevoets A.J.G.... Pannekoek H. (1999)
    3. Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells. (PubMed id 14724590)1, 2, 9 Kumar D.... Kasid U. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Expression of tumor necrosis factor-alpha-induced prot ein 8 in pancreas tissues and its correlation with epithelial growth factor rece ptor levels. (PubMed id 22631659)1 Liu K....Zhang D.Y. (2012)
    6. SCC-S2 is overexpressed in colon cancers and regulates cell proliferation. (PubMed id 22886548)1 Miao Z....Xu H. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. Tumor necrosis factor-a induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control stud y. (PubMed id 22666399)1 Zhang Y....Zhou X.Y. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Overexpression of SCC-S2 correlates with lymph node m etastasis and poor prognosis in patients with non-small-cell lung cancer. (PubMed id 20398053)1 Dong Q.Z....Wang E.H. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25816 HGNC: 17260 AceView: TNFAIP8 Ensembl:ENSG00000145779 euGenes: HUgn25816
    ECgene: TNFAIP8 H-InvDB: TNFAIP8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFAIP8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFAIP8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFAIP8 gene:
    Search GeneIP for patents involving TNFAIP8

    GeneCards and IP:
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