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TNFAIP8 Gene

protein-coding   GIFtS: 53
GCID: GC05P118604

Tumor Necrosis Factor, Alpha-Induced Protein 8

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor, Alpha-Induced Protein 81 2     TNF Alpha-Induced Protein 82 3
Head And Neck Tumor And Metastasis-Related Protein2 3     TNF-Induced Protein GG2-12 3
MDC-3.132 3     SCCS22 5
NDED2 3     GG2-12
SCC-S22 3     Tumor Necrosis Factor Alpha-Induced Protein 82
NF-Kappa-B-Inducible DED-Containing Protein2 3     

External Ids:    HGNC: 172601   Entrez Gene: 258162   Ensembl: ENSG000001457797   OMIM: 6121115   UniProtKB: O953793   

Export aliases for TNFAIP8 gene to outside databases

Previous GC identifers: GC00U914375 GC05P118768 GC05P118719 GC05P113799


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TNFAIP8 Gene:
TNFAIP8 (tumor necrosis factor, alpha-induced protein 8) is a protein-coding gene. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is TNFAIP8L2.

UniProtKB/Swiss-Prot: TFIP8_HUMAN, O95379
Function: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the
TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently
resulting in inhibition of BID cleavage and caspase-3 activation

Gene Wiki entry for TNFAIP8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFAIP8 gene promoter:
         HOXA9B   HOXA9   Elk-1   FOXD3   NF-kappaB   Meis-1b   Egr-2   ARP-1   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TNFAIP8 promoter sequence
   Search Chromatin IP Primers for TNFAIP8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFAIP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.1   Ensembl cytogenetic band:  5q23.1   HGNC cytogenetic band: 5q23.1

TNFAIP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFAIP8 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P118604:  view genomic region     (about GC identifiers)

Start:
118,604,387 bp from pter      End:
118,735,383 bp from pter
Size:
130,997 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TFIP8_HUMAN, O95379 (See protein sequence)
Recommended Name: Tumor necrosis factor alpha-induced protein 8  
Size: 198 amino acids; 23003 Da
Developmental stage: Expressed at high levels in the fetal liver, lung and kidney
Secondary accessions: B3KMH1 B3KMI2 Q9P1Q1 Q9UER5 Q9UP47
Alternative splicing: 3 isoforms:  O95379-1   O95379-2   O95379-3   

Explore the universe of human proteins at neXtProt for TNFAIP8: NX_O95379

Explore proteomics data for TNFAIP8 at MOPED


See TNFAIP8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (6 alternative transcripts): 
NP_001071122.1  NP_001273742.1  NP_001273743.1  NP_001273744.1  NP_001273746.1  NP_055165.2  

ENSEMBL proteins: 
 ENSP00000274456   ENSP00000429432   ENSP00000427424   ENSP00000422245   ENSP00000421848  
 ENSP00000427160   ENSP00000408534  

TNFAIP8 Human Recombinant Protein Products:

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Novus Biologicals TNFAIP8 Proteins
Novus Biologicals TNFAIP8 Lysates
Sino Biological Recombinant Protein for TNFAIP8
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ProSpec Recombinant Protein for TNFAIP8
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for TNFAIP8 

 
antibodies-online proteins for TNFAIP8 (9 products) 

 
antibodies-online peptides for TNFAIP8

TNFAIP8 Antibody Products:

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antibodies-online antibodies for TNFAIP8 (31 products) 

TNFAIP8 Assay Products:

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Search eBioscience for ELISAs for TNFAIP8 
antibodies-online kits for TNFAIP8 (8 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR008477 DUF758

Graphical View of Domain Structure for InterPro Entry O95379

ProtoNet protein and cluster: O95379

UniProtKB/Swiss-Prot: TFIP8_HUMAN, O95379
Similarity: Belongs to the TNFAIP8 family


Find genes that share domains with TNFAIP8           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TFIP8_HUMAN, O95379
Function: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the
TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently
resulting in inhibition of BID cleavage and caspase-3 activation
Induction: By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP10644768
     
Find genes that share ontologies with TNFAIP8           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for TNFAIP8

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat TNFAIP8 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate TNFAIP8 (see all 23):
hsa-miR-4291 hsa-miR-495 hsa-miR-607 hsa-miR-1271 hsa-miR-9 hsa-miR-7-1* hsa-miR-96 hsa-miR-761
SwitchGear 3'UTR luciferase reporter plasmidTNFAIP8 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for TNFAIP8
Predesigned siRNA for gene silencing in human, mouse, rat TNFAIP8

Gene Editing
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GenScript: all cDNA clones in your preferred vector (see all 2): TNFAIP8 (NM_014350)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFAIP8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFAIP8

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP8


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TFIP8_HUMAN, O95379: Cytoplasm
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus3
extracellular1
mitochondrion1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA14724590

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including TNFAIP8: 
          Apoptosis 384HT in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for TNFAIP8

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

Selected Interacting proteins for TNFAIP8 (O953792, 3 ENSP000004085344) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
MED4Q9NPJ62, 3, ENSP000002586484MINT-66580 I2D: score=5 STRING: ENSP00000258648
PTP4A1Q930963, ENSP000003596854I2D: score=2 STRING: ENSP00000359685
PTP4A2Q129743, ENSP000003449094I2D: score=2 STRING: ENSP00000344909
FLNCQ143153, ENSP000003271454I2D: score=1 STRING: ENSP00000327145
MAGEC2Q9UBF13I2D: score=1 
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0043066negative regulation of apoptotic process TAS10644768
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP10644768

Find genes that share ontologies with TNFAIP8           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TNFAIP8 (TFIP8)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TNFAIP8 gene (6 alternative transcripts): 
NM_001077654.2  NM_001286813.1  NM_001286814.1  NM_001286815.1  NM_001286817.1  NM_014350.3  

Unigene Cluster for TNFAIP8:

Tumor necrosis factor, alpha-induced protein 8
Hs.656274  [show with all ESTs]
Unigene Representative Sequence: AK097284
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000274456 ENST00000388882 ENST00000513374 ENST00000504771(uc003ksi.3)
ENST00000503646 ENST00000504642 ENST00000415806(uc003ksf.1 uc003ksg.3 uc011cwf.2)

miRNA
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Block miRNA regulation of human, mouse, rat TNFAIP8 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate TNFAIP8 (see all 23):
hsa-miR-4291 hsa-miR-495 hsa-miR-607 hsa-miR-1271 hsa-miR-9 hsa-miR-7-1* hsa-miR-96 hsa-miR-761
SwitchGear 3'UTR luciferase reporter plasmidTNFAIP8 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat TNFAIP8
Clone
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OriGene ORF clones in mouse, rat for TNFAIP8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): TNFAIP8 (NM_014350)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFAIP8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFAIP8
Primer
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OriGene qPCR primer pairs and template standards for TNFAIP8
OriGene qSTAR qPCR primer pairs in human, mouse for TNFAIP8
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNFAIP8
  QuantiTect SYBR Green Assays in human, mouse, rat TNFAIP8
  QuantiFast Probe-based Assays in human, mouse, rat TNFAIP8

Additional mRNA sequence: 

AF070671.1 AF098933.1 AF098934.1 AF099935.1 AF099936.1 AK001850.1 AK001931.1 AK097284.1 
AK097884.1 AK301281.1 BC005352.1 BC007014.1 CR457137.1 

13 DOTS entries:

DT.95374378  DT.213227  DT.95374380  DT.100023100  DT.120878808  DT.100023099  DT.100803903  DT.75151940 
DT.120878814  DT.95111430  DT.97801986  DT.100712480  DT.91976978 

Selected AceView cDNA sequences (see all 173):

AI978922 AI760403 BU674396 BP379054 AK097884 AI423860 AK001931 AA411104 
BG678510 BI819214 N50762 BU753619 AA868334 AF098934 BQ772421 BG178783 
CR615131 CR611795 CR615621 AU135377 AL527566 BM979655 AK001850 AA644572 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TNFAIP8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGCATAAAAA
TNFAIP8 Expression
About this image

TNFAIP8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TNFAIP8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.656274

UniProtKB/Swiss-Prot: TFIP8_HUMAN, O95379
Tissue specificity: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta.
Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells.
Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle

    Pathway & Disease-focused RT2 Profiler PCR Array including TNFAIP8: 
          Apoptosis 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for TNFAIP8
OriGene qSTAR qPCR primer pairs in human, mouse for TNFAIP8
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNFAIP8
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QuantiFast Probe-based Assays in human, mouse, rat TNFAIP8
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP8

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TNFAIP8 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tnfaip81 , 5 tumor necrosis factor, alpha-induced protein 81, 5 83.83(n)1
90.1(a)1
  18 (27.18 cM)5
1068691  NM_134131.21  NP_598892.21 
 499794275 
chicken
(Gallus gallus)
Aves TNFAIP81 tumor necrosis factor, alpha-induced protein 8 82.62(n)
89.89(a)
  427384  NM_001031441.2  NP_001026612.1 
lizard
(Anolis carolinensis)
Reptilia TNFAIP86
tumor necrosis factor, alpha-induced protein 8
87(a)
1 ↔ 1
GL343193.1(10489542-10513205)
African clawed frog
(Xenopus laevis)
Amphibia Xl.241562 Xenopus laevis transcribed sequence with moderate similarity more 78.06(n)    BX849289.1 
fruit fly
(Drosophila melanogaster)
Insecta CG40911 CG4091 51.11(n)
39.05(a)
  37751  NM_166622.1  NP_726358.2 


ENSEMBL Gene Tree for TNFAIP8 (if available)
TreeFam Gene Tree for TNFAIP8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TNFAIP8 gene
TNFAIP8L22  TNFAIP8L32  TNFAIP8L12  
3 SIMAP similar genes for TNFAIP8 using alignment to 5 protein entries:     TFIP8_HUMAN (see all proteins):
TNFAIP8L3    TNFAIP8L1    TNFAIP8L2

Find genes that share paralogs with TNFAIP8           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TNFAIP8 (see all 2935)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1862593441,2
--118602501(+) AAAACA/GAGTCT 1 -- us2k10--------
rs1909840471,2
--118602583(+) CACAGG/TCCTTG 1 -- us2k10--------
rs1465306861,2
--118602593(+) GGTTCA/GTGGTT 1 -- us2k10--------
rs799471141,2
C--118602596(+) TCGTGG/ATTCAG 1 -- us2k13Minor allele frequency- A:0.13CSA WA EA 240
rs758912051,2
C,F--118602619(+) TCACAC/GTTTGA 1 -- us2k11Minor allele frequency- G:0.08EA 120
rs13946251,2
C,F--118602669(+) TGTGAT/CTAGAT 1 -- us2k12Minor allele frequency- C:0.07NA 122
rs1832327961,2
--118602696(+) ATCCAA/GGATAA 1 -- us2k10--------
rs1879005141,2
--118602722(+) GCATCA/CATCTT 1 -- us2k10--------
rs359030681,2
C,F--118602770(+) CATGAC/TCGAAT 1 -- us2k13Minor allele frequency- T:0.33NA 6
rs13946261,2
C,F,A,H--118602909(+) TTTCAA/CTATTT 1 -- us2k15Minor allele frequency- C:0.02NS EA WA 536

HapMap Linkage Disequilibrium report for TNFAIP8 (118604387 - 118735383 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for TNFAIP8:    About this table    
Variant IDTypeSubtypePubMed ID
esv24760CNV Loss19812545
nsv882775CNV Gain21882294
dgv1846e1CNV Complex17122850

Human Gene Mutation Database (HGMD): TNFAIP8
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TNFAIP8
DNA2.0 Custom Variant and Variant Library Synthesis for TNFAIP8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612111    OMIM disorders: --


Find genes that share disorders with TNFAIP8           About GenesLikeMe

Genetic Association Database (GAD): TNFAIP8

Export disorders for TNFAIP8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TNFAIP8 gene, integrated from 10 sources (see all 27):
(articles sorted by number of sources associating them with TNFAIP8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein. (PubMed id 10644768)1, 2, 3 Kumar D.... Kasid U. (J. Biol. Chem. 2000)
  2. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PubMed id 10233894)1, 2, 3 Horrevoets A.J.G.... Pannekoek H. (Blood 1999)
  3. Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells. (PubMed id 14724590)1, 2, 9 Kumar D.... Kasid U. (Oncogene 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Functional variants in TNFAIP8 associated with cervical cancer susceptibility and clinical outcomes. (PubMed id 23299407)1 Shi T.Y....Wei Q. (Carcinogenesis 2013)
  6. The significance of TNFAIP8 in prostate cancer response to radiation and docetaxel and disease recurrence. (PubMed id 23280553)1 Zhang C....Kasid U.N. (Int. J. Cancer 2013)
  7. Expression of tumor necrosis factor-alpha-induced protein 8 in pancreas tissues and its correlation with epithelial growth factor receptor levels. (PubMed id 22631659)1 Liu K....Zhang D.Y. (Asian Pac. J. Cancer Prev. 2012)
  8. SCC-S2 is overexpressed in colon cancers and regulates cell proliferation. (PubMed id 22886548)1 Miao Z....Xu H. (Tumour Biol. 2012)
  9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
  10. Tumor necrosis factor-I+ induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study. (PubMed id 22666399)1 Zhang Y....Zhou X.Y. (PLoS ONE 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
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  Query String
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 25816 HGNC: 17260 AceView: TNFAIP8 Ensembl:ENSG00000145779 euGenes: HUgn25816
ECgene: TNFAIP8 H-InvDB: TNFAIP8

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TNFAIP8 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFAIP8 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TNFAIP8 gene:
Search GeneIP for patents involving TNFAIP8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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