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Aliases for TNFAIP8 Gene

Aliases for TNFAIP8 Gene

  • Tumor Necrosis Factor, Alpha-Induced Protein 8 2 3
  • Head And Neck Tumor And Metastasis-Related Protein 3 4
  • NF-Kappa-B-Inducible DED-Containing Protein 3 4
  • TNF Alpha-Induced Protein 8 3 4
  • TNF-Induced Protein GG2-1 3 4
  • MDC-3.13 3 4
  • SCC-S2 3 4
  • NDED 3 4
  • GG2-1 3
  • SCCS2 3

External Ids for TNFAIP8 Gene

Previous GeneCards Identifiers for TNFAIP8 Gene

  • GC00U914375
  • GC05P118768
  • GC05P118719
  • GC05P118604
  • GC05P113799

Summaries for TNFAIP8 Gene

GeneCards Summary for TNFAIP8 Gene

TNFAIP8 (Tumor Necrosis Factor, Alpha-Induced Protein 8) is a Protein Coding gene. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is TNFAIP8L2.

UniProtKB/Swiss-Prot for TNFAIP8 Gene

  • Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.

Gene Wiki entry for TNFAIP8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFAIP8 Gene

Genomics for TNFAIP8 Gene

Regulatory Elements for TNFAIP8 Gene

Genomic Location for TNFAIP8 Gene

Chromosome:
5
Start:
119,268,692 bp from pter
End:
119,399,688 bp from pter
Size:
130,997 bases
Orientation:
Plus strand

Genomic View for TNFAIP8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFAIP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP8 Gene

Proteins for TNFAIP8 Gene

  • Protein details for TNFAIP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95379-TFIP8_HUMAN
    Recommended name:
    Tumor necrosis factor alpha-induced protein 8
    Protein Accession:
    O95379
    Secondary Accessions:
    • B3KMH1
    • B3KMI2
    • B7Z713
    • Q9P1Q1
    • Q9UER5
    • Q9UP47

    Protein attributes for TNFAIP8 Gene

    Size:
    198 amino acids
    Molecular mass:
    23003 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TNFAIP8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFAIP8 Gene

Proteomics data for TNFAIP8 Gene at MOPED

Post-translational modifications for TNFAIP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for TNFAIP8 Gene

Domains & Families for TNFAIP8 Gene

Protein Domains for TNFAIP8 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O95379

UniProtKB/Swiss-Prot:

TFIP8_HUMAN :
  • Belongs to the TNFAIP8 family.
Family:
  • Belongs to the TNFAIP8 family.
genes like me logo Genes that share domains with TNFAIP8: view

No data available for Gene Families for TNFAIP8 Gene

Function for TNFAIP8 Gene

Molecular function for TNFAIP8 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
UniProtKB/Swiss-Prot Induction:
By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.

Gene Ontology (GO) - Molecular Function for TNFAIP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP 10644768
genes like me logo Genes that share ontologies with TNFAIP8: view
genes like me logo Genes that share phenotypes with TNFAIP8: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFAIP8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFAIP8 Gene

Localization for TNFAIP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFAIP8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFAIP8 Gene COMPARTMENTS Subcellular localization image for TNFAIP8 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for TNFAIP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 14724590
genes like me logo Genes that share ontologies with TNFAIP8: view

Pathways & Interactions for TNFAIP8 Gene

SuperPathways for TNFAIP8 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TNFAIP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032611 interleukin-1 beta production IEA --
GO:0043066 negative regulation of apoptotic process TAS 10644768
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP 10644768
GO:0050830 defense response to Gram-positive bacterium IEA --
genes like me logo Genes that share ontologies with TNFAIP8: view

No data available for Pathways by source and SIGNOR curated interactions for TNFAIP8 Gene

Drugs & Compounds for TNFAIP8 Gene

No Compound Related Data Available

Transcripts for TNFAIP8 Gene

Unigene Clusters for TNFAIP8 Gene

Tumor necrosis factor, alpha-induced protein 8:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFAIP8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP8 Gene

No ASD Table

Relevant External Links for TNFAIP8 Gene

GeneLoc Exon Structure for
TNFAIP8
ECgene alternative splicing isoforms for
TNFAIP8

Expression for TNFAIP8 Gene

mRNA expression in normal human tissues for TNFAIP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFAIP8 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for TNFAIP8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.7), Lymph node (10.0), and Tlymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNFAIP8 Gene



SOURCE GeneReport for Unigene cluster for TNFAIP8 Gene Hs.656274

mRNA Expression by UniProt/SwissProt for TNFAIP8 Gene

O95379-TFIP8_HUMAN
Tissue specificity: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.
genes like me logo Genes that share expression patterns with TNFAIP8: view

Protein tissue co-expression partners for TNFAIP8 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TNFAIP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNFAIP8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TNFAIP8 35
  • 90 (n)
  • 95.79 (a)
TNFAIP8 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNFAIP8 35
  • 90.35 (n)
  • 97.37 (a)
TNFAIP8 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnfaip8 35
  • 83.83 (n)
  • 90.1 (a)
Tnfaip8 16
Tnfaip8 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNFAIP8 35
  • 98.89 (n)
  • 100 (a)
TNFAIP8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfaip8 35
  • 85.94 (n)
  • 93.98 (a)
oppossum
(Monodelphis domestica)
Mammalia TNFAIP8 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFAIP8 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNFAIP8 35
  • 82.62 (n)
  • 89.89 (a)
TNFAIP8 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFAIP8 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfaip8 35
  • 77.48 (n)
  • 85.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24156 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002997 35
  • 49.56 (n)
  • 41.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4091 35
  • 51.11 (n)
  • 39.05 (a)
CG4091 36
  • 38 (a)
OneToMany
Species with no ortholog for TNFAIP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFAIP8 Gene

ENSEMBL:
Gene Tree for TNFAIP8 (if available)
TreeFam:
Gene Tree for TNFAIP8 (if available)

Paralogs for TNFAIP8 Gene

Paralogs for TNFAIP8 Gene

(3) SIMAP similar genes for TNFAIP8 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TNFAIP8: view

Variants for TNFAIP8 Gene

Sequence variations from dbSNP and Humsavar for TNFAIP8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_032047 -

Structural Variations from Database of Genomic Variants (DGV) for TNFAIP8 Gene

Variant ID Type Subtype PubMed ID
dgv1846e1 CNV Complex 17122850
nsv882775 CNV Gain 21882294
esv24760 CNV Loss 19812545

Variation tolerance for TNFAIP8 Gene

Residual Variation Intolerance Score: 46.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFAIP8 Gene

HapMap Linkage Disequilibrium report
TNFAIP8
Human Gene Mutation Database (HGMD)
TNFAIP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFAIP8 Gene

Disorders for TNFAIP8 Gene

Relevant External Links for TNFAIP8

Genetic Association Database (GAD)
TNFAIP8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFAIP8
genes like me logo Genes that share disorders with TNFAIP8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFAIP8 Gene

Publications for TNFAIP8 Gene

  1. Role of SCC-S2 in experimental metastasis and modulation of VEGFR-2, MMP-1, and MMP-9 expression. (PMID: 16455304) Zhang C. … Kasid U.N. (Mol. Ther. 2006) 23 67
  2. Spontaneous neutrophil apoptosis and regulation of cell survival by granulocyte macrophage-colony stimulating factor. (PMID: 16204629) Kobayashi S.D. … DeLeo F.R. (J. Leukoc. Biol. 2005) 23 67
  3. Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells. (PMID: 14724590) Kumar D. … Kasid U. (Oncogene 2004) 23 67
  4. Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein. (PMID: 10644768) Kumar D. … Kasid U. (J. Biol. Chem. 2000) 2 67
  5. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PMID: 10233894) Horrevoets A.J.G. … Pannekoek H. (Blood 1999) 2 67

Products for TNFAIP8 Gene

Sources for TNFAIP8 Gene

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