TNFAIP8 Gene

Aliases
for TNFAIP8 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC00U914375 GC05P118768 GC05P118719 GC05P113799

Summaries
for TNFAIP8 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for TNFAIP8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000005.9  NT_034772.7  NC_018916.2  

SwitchGear Promoter luciferase reporter plasmids (see all 3): TNFAIP8 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFAIP8

TNFAIP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P118604:  view genomic region     (about GC identifiers)

Proteins
for TNFAIP8 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for TNFAIP8: NX_O95379

Explore proteomics data for TNFAIP8 at MOPED


See TNFAIP8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

TNFAIP8 Human Recombinant Protein Products:

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	GeneTex Proteins for TNFAIP8:                       TNF alpha IP8 Protein (GTX111940-pro)
	antibodies-online proteins for TNFAIP8 (9 products)
	antibodies-online peptides for TNFAIP8

TNFAIP8 Antibody Products:

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TNFAIP8 Assay Products:

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	Search eBioscience for ELISAs for TNFAIP8
	antibodies-online kits for TNFAIP8 (8 products)

Domains /
Families
for TNFAIP8 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: O95379

Find genes that share domains with TNFAIP8           About GenesLikeMe

Function
for TNFAIP8 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for TNFAIP8

miRNA Products:		Block miRNA regulation of human, mouse, rat TNFAIP8 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TNFAIP8 (see all 23):
		hsa-miR-4291 hsa-miR-495 hsa-miR-607 hsa-miR-1271 hsa-miR-9 hsa-miR-7-1* hsa-miR-96 hsa-miR-761
		SwitchGear 3'UTR luciferase reporter plasmid: TNFAIP8 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TNFAIP8
		Predesigned siRNA for gene silencing in human, mouse, rat TNFAIP8

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TNFAIP8

Clone Products:		OriGene clones in human, mouse for TNFAIP8 (see all 13) OriGene ORF clones in mouse, rat for TNFAIP8 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TNFAIP8 (NM_014350)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFAIP8
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP8

Localization
for TNFAIP8 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	3
nucleus	3
extracellular	1
mitochondrion	1
peroxisome	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for TNFAIP8 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for TNFAIP8 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for TNFAIP8 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for TNFAIP8 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TNFAIP8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGCATAAAAA

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for TNFAIP8 OriGene qSTAR qPCR primer pairs in human, mouse for TNFAIP8
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNFAIP8
		QuantiTect SYBR Green Assays in human, mouse, rat TNFAIP8
		QuantiFast Probe-based Assays in human, mouse, rat TNFAIP8

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP8

Orthologs
for TNFAIP8 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for TNFAIP8 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for TNFAIP8 gene

TNFAIP8L2²  TNFAIP8L3²  TNFAIP8L1²  

3 SIMAP similar genes for TNFAIP8 using alignment to 5 protein entries:     TFIP8_HUMAN (see all proteins):

TNFAIP8L3    TNFAIP8L1    TNFAIP8L2

Find genes that share paralogs with TNFAIP8           About GenesLikeMe

Genomic Variants
for TNFAIP8 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TNFAIP8 (see all 2935)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1862593441,2		--	118602501(+)	AAAACA/GAGTCT	1	--	us2k1		0	--	--	--	--
rs1909840471,2		--	118602583(+)	CACAGG/TCCTTG	1	--	us2k1		0	--	--	--	--
rs1465306861,2		--	118602593(+)	GGTTCA/GTGGTT	1	--	us2k1		0	--	--	--	--
rs799471141,2	C	--	118602596(+)	TCGTGG/ATTCAG	1	--	us2k1		3		CSA WA EA	240
rs758912051,2	C,F	--	118602619(+)	TCACAC/GTTTGA	1	--	us2k1		1		EA	120
rs13946251,2	C,F	--	118602669(+)	TGTGAT/CTAGAT	1	--	us2k1		2		NA	122
rs1832327961,2		--	118602696(+)	ATCCAA/GGATAA	1	--	us2k1		0	--	--	--	--
rs1879005141,2		--	118602722(+)	GCATCA/CATCTT	1	--	us2k1		0	--	--	--	--
rs359030681,2	C,F	--	118602770(+)	CATGAC/TCGAAT	1	--	us2k1		3		NA	6
rs13946261,2	C,F,A,H	--	118602909(+)	TTTCAA/CTATTT	1	--	us2k1		5		NS EA WA	536

HapMap Linkage Disequilibrium report for TNFAIP8 (118604387 - 118735383 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for TNFAIP8:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv24760	CNV	Loss	19812545
nsv882775	CNV	Gain	21882294
dgv1846e1	CNV	Complex	17122850

Human Gene Mutation Database (HGMD): TNFAIP8

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TNFAIP8

DNA2.0 Custom Variant and Variant Library Synthesis for TNFAIP8

Disorders / Diseases
for TNFAIP8 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for TNFAIP8 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein. (PubMed id 10644768)^{1, 2, 3} Kumar D.... Kasid U. (J. Biol. Chem. 2000)
2. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PubMed id 10233894)^{1, 2, 3} Horrevoets A.J.G.... Pannekoek H. (Blood 1999)
3. Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells. (PubMed id 14724590)^{1, 2, 9} Kumar D.... Kasid U. (Oncogene 2004)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
5. Functional variants in TNFAIP8 associated with cervical cancer susceptibility and clinical outcomes. (PubMed id 23299407)¹ Shi T.Y....Wei Q. (Carcinogenesis 2013)
6. The significance of TNFAIP8 in prostate cancer response to radiation and docetaxel and disease recurrence. (PubMed id 23280553)¹ Zhang C....Kasid U.N. (Int. J. Cancer 2013)
7. Expression of tumor necrosis factor-alpha-induced protein 8 in pancreas tissues and its correlation with epithelial growth factor receptor levels. (PubMed id 22631659)¹ Liu K....Zhang D.Y. (Asian Pac. J. Cancer Prev. 2012)
8. SCC-S2 is overexpressed in colon cancers and regulates cell proliferation. (PubMed id 22886548)¹ Miao Z....Xu H. (Tumour Biol. 2012)
9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (Nat. Methods 2012)
10. Tumor necrosis factor-I+ induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study. (PubMed id 22666399)¹ Zhang Y....Zhou X.Y. (PLoS ONE 2012)

External Searches for TNFAIP8 gene

Genome Databases showing TNFAIP8 gene

Other Databases showing TNFAIP8 gene

Specialized Databases showing TNFAIP8 gene

Products
for TNFAIP8 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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