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Aliases for TNFAIP8 Gene

Aliases for TNFAIP8 Gene

  • TNF Alpha Induced Protein 8 2 3 5
  • Head And Neck Tumor And Metastasis-Related Protein 3 4
  • NF-Kappa-B-Inducible DED-Containing Protein 3 4
  • TNF-Induced Protein GG2-1 3 4
  • MDC-3.13 3 4
  • SCC-S2 3 4
  • NDED 3 4
  • Tumor Necrosis Factor, Alpha-Induced Protein 8 2
  • Tumor Necrosis Factor, Alpha Induced Protein 8 3
  • Tumor Necrosis Factor Alpha-Induced Protein 8 3
  • TNF Alpha-Induced Protein 8 4
  • GG2-1 3
  • SCCS2 3

External Ids for TNFAIP8 Gene

Previous GeneCards Identifiers for TNFAIP8 Gene

  • GC00U914375
  • GC05P118768
  • GC05P118719
  • GC05P118604
  • GC05P113799

Summaries for TNFAIP8 Gene

GeneCards Summary for TNFAIP8 Gene

TNFAIP8 (TNF Alpha Induced Protein 8) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is TNFAIP8L3.

UniProtKB/Swiss-Prot for TNFAIP8 Gene

  • Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.

Gene Wiki entry for TNFAIP8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFAIP8 Gene

Genomics for TNFAIP8 Gene

Regulatory Elements for TNFAIP8 Gene

Enhancers for TNFAIP8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G119317 2 FANTOM5 Ensembl ENCODE dbSUPER 58.1 +62.9 62855 27.1 CREB3L1 FEZF1 ZNF143 ZNF263 TBX21 MEF2D ZNF610 ZNF585B GLIS1 NBN TNFAIP8 DMXL1 LOC105379143 FAM170A HSD17B4 ENSG00000249426 GC05P119341 RN7SL174P GC05M119307
GH05G119397 1.8 FANTOM5 Ensembl ENCODE dbSUPER 45.2 +129.8 129809 3.0 TBP TBL1XR1 WRNIP1 BMI1 RAD21 ZBTB40 YY1 CBX5 ZNF207 FOS TNFAIP8 DMXL1 DTWD2 LOC105379143 LOC102723444 GC05P119446
GH05G119410 1.7 FANTOM5 Ensembl ENCODE dbSUPER 44.7 +143.1 143076 2.1 HDAC1 PKNOX1 ATF1 RB1 ARNT ARID4B SIN3A ZNF2 RAD21 YY1 TNFAIP8 DTWD2 ENSG00000250678 RNU6-373P HSD17B4 FAM170A DMXL1 GC05P119446 LOC102723444
GH05G119388 1.4 FANTOM5 Ensembl ENCODE dbSUPER 50.6 +120.9 120898 1.7 ZNF121 GATA3 ZNF316 RCOR2 FEZF1 ZNF384 RARA TNFAIP8 DMXL1 LOC105379143 LOC102723444 GC05P119446
GH05G119267 2 FANTOM5 Ensembl ENCODE dbSUPER 24.7 +4.9 4942 12.3 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TNFAIP8 DTWD2 DMXL1 GC05P119298
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFAIP8 on UCSC Golden Path with GeneCards custom track

Promoters for TNFAIP8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000185753 308 2401 HDGF ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 ZNF143

Genomic Location for TNFAIP8 Gene

Chromosome:
5
Start:
119,268,692 bp from pter
End:
119,399,688 bp from pter
Size:
130,997 bases
Orientation:
Plus strand

Genomic View for TNFAIP8 Gene

Genes around TNFAIP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFAIP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFAIP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP8 Gene

Proteins for TNFAIP8 Gene

  • Protein details for TNFAIP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95379-TFIP8_HUMAN
    Recommended name:
    Tumor necrosis factor alpha-induced protein 8
    Protein Accession:
    O95379
    Secondary Accessions:
    • B3KMH1
    • B3KMI2
    • B7Z713
    • Q9P1Q1
    • Q9UER5
    • Q9UP47

    Protein attributes for TNFAIP8 Gene

    Size:
    198 amino acids
    Molecular mass:
    23003 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TNFAIP8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFAIP8 Gene

Post-translational modifications for TNFAIP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TNFAIP8 Gene

Domains & Families for TNFAIP8 Gene

Protein Domains for TNFAIP8 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O95379

UniProtKB/Swiss-Prot:

TFIP8_HUMAN :
  • Belongs to the TNFAIP8 family.
Family:
  • Belongs to the TNFAIP8 family.
genes like me logo Genes that share domains with TNFAIP8: view

No data available for Gene Families for TNFAIP8 Gene

Function for TNFAIP8 Gene

Molecular function for TNFAIP8 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
UniProtKB/Swiss-Prot Induction:
By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.

Gene Ontology (GO) - Molecular Function for TNFAIP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP 10644768
genes like me logo Genes that share ontologies with TNFAIP8: view
genes like me logo Genes that share phenotypes with TNFAIP8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFAIP8 Gene

Localization for TNFAIP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFAIP8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFAIP8 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TNFAIP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 14724590
genes like me logo Genes that share ontologies with TNFAIP8: view

Pathways & Interactions for TNFAIP8 Gene

genes like me logo Genes that share pathways with TNFAIP8: view

Pathways by source for TNFAIP8 Gene

Gene Ontology (GO) - Biological Process for TNFAIP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0043065 positive regulation of apoptotic process IMP 10644768
GO:0043066 negative regulation of apoptotic process TAS 10644768
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA --
genes like me logo Genes that share ontologies with TNFAIP8: view

No data available for SIGNOR curated interactions for TNFAIP8 Gene

Drugs & Compounds for TNFAIP8 Gene

No Compound Related Data Available

Transcripts for TNFAIP8 Gene

Unigene Clusters for TNFAIP8 Gene

Tumor necrosis factor, alpha-induced protein 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP8 Gene

No ASD Table

Relevant External Links for TNFAIP8 Gene

GeneLoc Exon Structure for
TNFAIP8
ECgene alternative splicing isoforms for
TNFAIP8

Expression for TNFAIP8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFAIP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFAIP8 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for TNFAIP8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.7), Lymph node (10.0), and Tlymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNFAIP8 Gene



Protein tissue co-expression partners for TNFAIP8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNFAIP8 Gene:

TNFAIP8

SOURCE GeneReport for Unigene cluster for TNFAIP8 Gene:

Hs.656274

mRNA Expression by UniProt/SwissProt for TNFAIP8 Gene:

O95379-TFIP8_HUMAN
Tissue specificity: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.

Evidence on tissue expression from TISSUES for TNFAIP8 Gene

  • Stomach(4.3)
  • Heart(4.2)
  • Nervous system(4.1)
  • Lymph node(2.6)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with TNFAIP8: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFAIP8 Gene

Orthologs for TNFAIP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNFAIP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFAIP8 34 35
  • 98.89 (n)
oppossum
(Monodelphis domestica)
Mammalia TNFAIP8 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFAIP8 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNFAIP8 34 35
  • 90.35 (n)
cow
(Bos Taurus)
Mammalia TNFAIP8 34 35
  • 90 (n)
rat
(Rattus norvegicus)
Mammalia Tnfaip8 34
  • 85.94 (n)
mouse
(Mus musculus)
Mammalia Tnfaip8 34 16 35
  • 83.83 (n)
chicken
(Gallus gallus)
Aves TNFAIP8 34 35
  • 82.62 (n)
lizard
(Anolis carolinensis)
Reptilia TNFAIP8 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfaip8 34
  • 77.48 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24156 34
fruit fly
(Drosophila melanogaster)
Insecta CG4091 34 35
  • 51.11 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002997 34
  • 49.56 (n)
Species where no ortholog for TNFAIP8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFAIP8 Gene

ENSEMBL:
Gene Tree for TNFAIP8 (if available)
TreeFam:
Gene Tree for TNFAIP8 (if available)

Paralogs for TNFAIP8 Gene

Paralogs for TNFAIP8 Gene

(3) SIMAP similar genes for TNFAIP8 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TNFAIP8: view

Variants for TNFAIP8 Gene

Sequence variations from dbSNP and Humsavar for TNFAIP8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000021812 -- 119,300,246(+) CAGCC(A/G)TCTTG intron-variant
rs1000028936 -- 119,370,072(+) CCCTT(C/G)TGTTT intron-variant
rs1000042573 -- 119,291,521(+) AACTC(A/G)TGGAT intron-variant
rs1000051197 -- 119,301,559(+) GCTGG(A/G)GACAT intron-variant
rs1000061478 -- 119,369,860(+) CGCCT(A/G)AAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFAIP8 Gene

Variant ID Type Subtype PubMed ID
dgv10045n54 CNV loss 21841781
esv24760 CNV loss 19812545
esv2759374 CNV loss 17122850
esv3606480 CNV loss 21293372
esv3606482 CNV gain 21293372
esv3606483 CNV loss 21293372
esv3606484 CNV loss 21293372
nsv1016595 CNV gain 25217958
nsv1024648 CNV gain 25217958
nsv1115702 CNV duplication 24896259
nsv1131910 CNV deletion 24896259
nsv599564 CNV gain 21841781
nsv599565 CNV gain 21841781
nsv950121 CNV duplication 24416366
nsv950122 CNV duplication 24416366

Variation tolerance for TNFAIP8 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFAIP8 Gene

Human Gene Mutation Database (HGMD)
TNFAIP8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFAIP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFAIP8 Gene

Disorders for TNFAIP8 Gene

Relevant External Links for TNFAIP8

Genetic Association Database (GAD)
TNFAIP8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFAIP8

No disorders were found for TNFAIP8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFAIP8 Gene

Publications for TNFAIP8 Gene

  1. Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells. (PMID: 14724590) Kumar D. … Kasid U. (Oncogene 2004) 3 4 22 64
  2. Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein. (PMID: 10644768) Kumar D. … Kasid U. (J. Biol. Chem. 2000) 2 3 4 64
  3. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PMID: 10233894) Horrevoets A.J.G. … Pannekoek H. (Blood 1999) 2 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. MicroRNA-9 inhibits the gastric cancer cell proliferation by targeting TNFAIP8. (PMID: 28127811) Gao H.Y. … Pei D.S. (Cell Prolif. 2017) 3 64

Products for TNFAIP8 Gene

Sources for TNFAIP8 Gene

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