Aliases for TNFAIP6 Gene
External Ids for TNFAIP6 Gene
Previous GeneCards Identifiers for TNFAIP6 Gene
The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]
GeneCards Summary for TNFAIP6 Gene
TNFAIP6 (TNF Alpha Induced Protein 6) is a Protein Coding gene. Diseases associated with TNFAIP6 include Arthritis and Rheumatoid Arthritis. Among its related pathways are Akt Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include hyaluronic acid binding. An important paralog of this gene is VCAN.
UniProtKB/Swiss-Prot for TNFAIP6 Gene
Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.