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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFAIP6 Gene

protein-coding   GIFtS: 56
GCID: GC02P152178

tumor necrosis factor, alpha-induced protein 6
 Explore 20 diseases affiliated with
TNFAIP6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TNFAIP6    

Aliases
for TNFAIP6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Necrosis Factor, Alpha-Induced Protein 61 2     TNF-Stimulated Gene 6 Protein2 3
TSG-61 2 3     Tumor Necrosis Factor Alpha-Inducible Protein 62
TSG61 2 3     Tumor Necrosis Factor-Inducible Gene 6 Protein2
Hyaluronate-Binding Protein2 3     Tumor Necrosis Factor-Stimulated Gene-6 Protein2
TNF Alpha-Induced Protein 62 3     Tumor Necrosis Factor Alpha-Induced Protein 63

External Ids:    HGNC: 118981   Entrez Gene: 71302   Ensembl: ENSG000001236107   OMIM: 6004105   UniProtKB: P980663   

Export aliases for TNFAIP6 gene to outside databases

Previous GC identifers: GC02P149908 GC02P150743 GC02P152416 GC02P152039 GC02P151922 GC02P144110


Summaries
for TNFAIP6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TNFAIP6:
The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member
of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular
matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor
(I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease
network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis
factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with
osteoarthritis and rheumatoid arthritis.(provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: TSG6_HUMAN, P98066
Function: Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis

Gene Wiki entry for TNFAIP6 (TSG-6)


Genomic Views
for TNFAIP6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFAIP6 gene promoter:
         STAT1   STAT4   STAT1beta   NF-kappaB   STAT1alpha   NF-kappaB2   STAT2   STAT3   NF-kappaB1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFAIP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFAIP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFAIP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23.3   Ensembl cytogenetic band:  2q23.3   HGNC cytogenetic band: 2q23.3

TNFAIP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFAIP6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P152178:  view genomic region     (about GC identifiers)

Start:
 152,214,105 bp from pter      End:
 152,236,560 bp from pter
Size:
 22,456 bases      Orientation:
 plus strand

Proteins
for TNFAIP6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TSG6_HUMAN, P98066 (See protein sequence)
Recommended Name: Tumor necrosis factor-inducible gene 6 protein precursor  
Size: 277 amino acids; 31203 Da
Subunit: Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability of the
complex
4 PDB 3D structures from and Proteopedia for TNFAIP6:
1O7B (3D)        1O7C (3D)        2PF5 (3D)        2WNO (3D)    
Secondary accessions: Q53TI7 Q8WWI9

Explore the universe of human proteins at neXtProt for TNFAIP6: NX_P98066

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P98066

    • TNFAIP6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_009046.2  
    ENSEMBL proteins: 
     ENSP00000243347  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: TNFAIP6
    OriGene Custom Protein Services for TNFAIP6 
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    Novus Biologicals TNFAIP6 Protein
    Novus Biologicals TNFAIP6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn


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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for TNFAIP6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TNFAIP6 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000859 CUB_dom
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR000538 Link

    Graphical View of Domain Structure for InterPro Entry P98066

    ProtoNet protein and cluster: P98066

    2 Blocks protein families:
    IPB000538 Link domain
    IPB000859 CUB domain


    UniProtKB/Swiss-Prot: TSG6_HUMAN, P98066
    Similarity: Contains 1 CUB domain
    Similarity: Contains 1 Link domain


    Function
    for TNFAIP6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TSG6_HUMAN, P98066
    Function: Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis
    Induction: By TNF

         Genatlas biochemistry entry for TNFAIP6:
    tumor necrosis factor,alpha-induced protein 6

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFAIP6:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmid: TNFAIP6 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFAIP6 (see all 7)
    OriGene shRNA RFP: TNFAIP6
    OriGene siRNA: TNFAIP6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFAIP6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TNFAIP6

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFAIP6 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TNFAIP6 (NM_007115)
    Sino Biological Human cDNA Clone for TNFAIP6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFAIP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFAIP6 

    Cell Line
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    Search LifeMap BioReagents cell lines for TNFAIP6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP6

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005540hyaluronic acid binding IEA--


    TNFAIP6 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Tnfaip6tm1Cful for TNFAIP6
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tnfaip6):
     endocrine/exocrine gland  reproductive system 

    TNFAIP6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TNFAIP6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    2PAK Pathway
    		Antioxidant Action of Vitamin-C0.56
    3Rho Family GTPases
    		Molecular Mechanisms of Cancer0.51
    4PEDF Induced Signaling
    		STAT3 Pathway0.47

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFAIP6 (see all 6)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFAIP6

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for TNFAIP6 (P980663 ENSP000002433474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    THBS1P079963, ENSP000002603564I2D: score=1 STRING: ENSP00000260356
    --E7EX883I2D: score=2 
    --ENSP000002681344STRING: ENSP00000268134
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response TAS1730767
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS1730767
    GO:0007267cell-cell signaling TAS1730767


    TNFAIP6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TNFAIP6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNFAIP6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFAIP6

    1 HMDB Compound for TNFAIP6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronic acidhyaluronic acid 9004-61-9--
    9 Novoseek chemical compound relationships for TNFAIP6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycosaminoglycan 60.8 5 9237673 (1), 18820257 (1)
    chondroitin sulfate 59.4 11 16768462 (3), 16289010 (2), 17635118 (1), 15840581 (1)
    hyaluronic acid 44.2 4 1710472 (1), 11943733 (1), 2210971 (1)
    heparin 33 7 15917224 (2), 18226512 (1), 15183770 (1)
    serine 19.9 6 9244409 (2), 8568267 (1), 12401803 (1), 12692188 (1) (see all 5)
    pge2 12.7 9 11943733 (6)
    calcium 0 5 14723873 (2), 12622693 (1), 16006654 (1), 18226512 (1)
    tyrosine 0 1 15718240 (1)
    dexamethasone 0 1 8568267 (1)

    Search CenterWatch for drugs/clinical trials and news about TNFAIP6 / TSG6 

    Transcripts
    for TNFAIP6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TNFAIP6 gene: 
    NM_007115.3  

    Unigene Cluster for TNFAIP6:

    Tumor necrosis factor, alpha-induced protein 6
    Hs.437322  [show with all ESTs]
    Unigene Representative Sequence: NM_007115
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000243347(uc002txk.3) ENST00000460812

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFAIP6:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmid: TNFAIP6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFAIP6 (see all 7)
    OriGene shRNA RFP: TNFAIP6
    OriGene siRNA: TNFAIP6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFAIP6
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFAIP6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFAIP6
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TNFAIP6 (NM_007115)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFAIP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFAIP6 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFAIP6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNFAIP6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFAIP6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFAIP6

    Additional cDNA sequence: 

    AF086484.1 AJ419936.1 AJ421518.1 BC030205.1 M31164.1 M31165.1 

    4 DOTS entries:

    DT.312975  DT.120976147  DT.40110898  DT.75161440 

    24/70 AceView cDNA sequences (see all 70):

    AA039722 NM_007115 AI225126 AU098413 AW020995 W93163 AF086484 AI865870 
    BI491954 CA308497 AA507959 CD366440 CA415298 BC030205 AJ419936 AA363579 
    AI168135 BX099048 BQ575738 AW057612 AA628236 AW469420 BM908074 AV682307 

    GeneLoc Exon Structure


    Expression
    for TNFAIP6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFAIP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTTTAAACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TNFAIP6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    OvaryAntral FollicleCumulus CellsOvary
    Head MesenchymeBranchial Arch 1Paraxial Mesoderm CellsBone, Skeletal Muscle
    HeartMyocardiumCardiac FibroblastsEpicardium
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)

    See TNFAIP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFAIP6

    SOURCE GeneReport for Unigene cluster: Hs.437322

    UniProtKB/Swiss-Prot: TSG6_HUMAN, P98066
    Tissue specificity: Found in the synovial fluid of patients with rheumatoid arthritis

        SABiosciences Expression via Pathway-Focused PCR Array including TNFAIP6: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFAIP6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP6

    Orthologs
    for TNFAIP6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TNFAIP6 gene from 3/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TNFAIP61 tumor necrosis factor, alpha-induced protein 6 77.08(n)
    81.25(a)    		   424315  NM_001037837.2  NP_001032926.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TNFAIP66
    		 --
    		 64(a)
    		 1 ↔ 1
    		 GL343302.1(1289228-1316412)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.177382 Transcribed sequence with weak similarity to protein more 74.88(n)    BQ615550.1 


    ENSEMBL Gene Tree for TNFAIP6 (if available)
    TreeFam Gene Tree for TNFAIP6 (if available) 

    Paralogs
    for TNFAIP6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFAIP6 gene
    NAGPA2  STAB22  STAB12  MEGF102  SCARF22  MEGF62  MEGF112  SCARF12  
    PEAR12  

    TNFAIP6 for paralogs           About GeneDecksing



    Genomic Variants
    for TNFAIP6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/431 NCBI SNPs in TNFAIP6 are shown (see all 431)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs109305761,2
    		C,F,H,--152212156(+) ACTTAC/AATCAT 1 -- us2k111Minor allele frequency- A:0.10NA EA NS CSA WA 656
    rs1135372381,2
    		C,--152212310(+) CAAAGC/AAACTC 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1497844911,2
    		--152212357(+) ACTTCA/GCTCTA 1 -- us2k10--------
    rs37554791,2
    		C,--152212399(+) AGAAGG/TGTATC 1 -- us2k15Minor allele frequency- T:0.09EA CSA WA NA 1856
    rs1450819521,2
    		--152212412(+) TTCTTA/TGTTAT 1 -- us2k10--------
    rs1881027801,2
    		C,--152212663(+) TCATGA/GTTTAT 1 -- us2k10--------
    rs1491150371,2
    		--152212681(+) AACTAC/TCTATG 1 -- us2k10--------
    rs124673891,2
    		C,F,H--152212957(+) AACACG/ACCTGA 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1431087131,2
    		--152213063(+) GGAGGG/TACTAA 1 -- us2k10--------
    rs1478303451,2
    		--152213088(+) AATGAA/GTGCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TNFAIP6 (152214105 - 152236560 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TNFAIP6
         2 CNVs: 90079 8961

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFAIP6
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFAIP6

    Disorders / Diseases
    for TNFAIP6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TNFAIP6 for disorders           About GeneDecksing

    OMIM gene information: 600410    OMIM disorders: --

    20 diseases for TNFAIP6:    About MalaCards
    chronic active epstein-barr virus infection    rheumatoid arthritis    osteoarthritis    arthritis
    dermatofibrosarcoma protuberans    dermatofibrosarcoma    myxoma    kawasaki disease
    keratoconus    keloids    hepatitis b    noma
    ovarian cancer    colorectal cancer    hepatitis    cervicitis
    cholesterol    adenocarcinoma    leukemia    prostatitis

    7 Novoseek disease relationships for TNFAIP6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 64 71 7935377 (2), 11145024 (2), 16547399 (2), 8454591 (2) (see all 47)
    arthritis 51.4 31 12355494 (6), 8245487 (5), 11145024 (3), 18586671 (2) (see all 11)
    inflammation 44.3 31 8568267 (3), 9244409 (2), 15110797 (2), 12692188 (2) (see all 19)
    tumors 42.5 66 16467113 (3), 7935377 (2), 11145024 (2), 16547399 (2) (see all 41)
    rheumatoid arthritis 36.4 7 11145024 (1), 8245487 (1), 8568267 (1), 11178946 (1) (see all 7)
    osteoarthritis 18.1 2 11178946 (1), 11854277 (1)
    asthma 0 2 17307731 (1), 16873769 (1)

    Genetic Association Database (GAD): TNFAIP6
    Human Genome Epidemiology (HuGE) Navigator: TNFAIP6 (6 documents)

    Export disorders for TNFAIP6 gene to outside databases

    Publications
    for TNFAIP6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFAIP6 gene, integrated from 9 sources (see all 109):
    (articles sorted by number of sources associating them with TNFAIP6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44. (PubMed id 1730767)1, 2, 3, 9 Lee T.H.... Vilcek J. (1992)
    2. A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression. (PubMed id 11854277)1, 2, 4, 9 Nentwich H.A.... Day A.J. (2002)
    3. TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo. (PubMed id 8568267)1, 3, 9 Wisniewski H.G....Cronstein B.N. (1996)
    4. TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor. (PubMed id 7516184)1, 2, 9 Wisniewski H.-G.... Vilcek J. (1994)
    5. TSG-6 modulates the interaction between hyaluronan and cell surface CD44. (PubMed id 15060082)1, 3, 9 Lesley J....Mikecz K. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration. (PubMed id 8797823)1, 2 Kohda D.... Day A.J. (1996)
    8. Coregulation in human leukocytes of the long pentraxi n PTX3 and TSG-6. (PubMed id 19389798)1, 9 Maina V....Garlanda C. (2009)
    9. TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation. (PubMed id 18586671)1, 9 Mahoney D.J....Sabokbar A. (2008)
    10. Transcriptional regulation of TSG6, a tumor necrosis factor- and interleukin-1-inducible primary response gene coding for a secreted hyaluronan-binding protein. (PubMed id 8454591)1, 9 Lee T.H....Vilcek J. (1993)

    External Searches for TNFAIP6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing TNFAIP6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7130 HGNC: 11898 AceView: TNFAIP6 Ensembl:ENSG00000123610 euGenes: HUgn7130
    ECgene: TNFAIP6 H-InvDB: TNFAIP6

    Other Databases showing TNFAIP6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TNFAIP6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFAIP6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFAIP6 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TNFAIP6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TNFAIP6 gene:
    Search GeneIP for patents involving TNFAIP6

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