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TNFAIP6 Gene

protein-coding   GIFtS: 56
GCID: GC02P152178

Tumor Necrosis Factor, Alpha-Induced Protein 6

  See TNFAIP6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor, Alpha-Induced Protein 61 2     TNF-Stimulated Gene 6 Protein2 3
Hyaluronate-Binding Protein2 3     Tumor Necrosis Factor Alpha-Inducible Protein 62
TSG-62 3     Tumor Necrosis Factor-Inducible Gene 6 Protein2
TSG62 3     Tumor Necrosis Factor-Stimulated Gene-6 Protein2
TNF Alpha-Induced Protein 62 3     Tumor Necrosis Factor Alpha-Induced Protein 63

External Ids:    HGNC: 118981   Entrez Gene: 71302   Ensembl: ENSG000001236107   OMIM: 6004105   UniProtKB: P980663   

Export aliases for TNFAIP6 gene to outside databases

Previous GC identifers: GC02P149908 GC02P150743 GC02P152416 GC02P152039 GC02P151922 GC02P144110


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFAIP6 Gene:
The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a
member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in
extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with
inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which
is important in the protease network associated with inflammation. This gene can be induced by proinflammatory
cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the
synovial fluid of patients with osteoarthritis and rheumatoid arthritis.(provided by RefSeq, Dec 2010)

GeneCards Summary for TNFAIP6 Gene:
TNFAIP6 (tumor necrosis factor, alpha-induced protein 6) is a protein-coding gene. Diseases associated with TNFAIP6 include osteoarthritis, and chronic active epstein-barr virus infection. GO annotations related to this gene include hyaluronic acid binding. An important paralog of this gene is STAB2.

UniProtKB/Swiss-Prot: TSG6_HUMAN, P98066
Function: Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis

Gene Wiki entry for TNFAIP6 (TSG-6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFAIP6 gene promoter:
         STAT1   STAT4   STAT1beta   NF-kappaB   STAT1alpha   NF-kappaB2   STAT2   STAT3   NF-kappaB1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFAIP6 promoter sequence
   Search Chromatin IP Primers for TNFAIP6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFAIP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23.3   Ensembl cytogenetic band:  2q23.3   HGNC cytogenetic band: 2q23.3

TNFAIP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFAIP6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P152178:  view genomic region     (about GC identifiers)

Start:
152,214,106 bp from pter      End:
152,236,562 bp from pter
Size:
22,457 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TSG6_HUMAN, P98066 (See protein sequence)
Recommended Name: Tumor necrosis factor-inducible gene 6 protein precursor  
Size: 277 amino acids; 31203 Da
Subunit: Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability
of the complex
4 PDB 3D structures from and Proteopedia for TNFAIP6:
1O7B (3D)        1O7C (3D)        2PF5 (3D)        2WNO (3D)    
Secondary accessions: Q53TI7 Q8WWI9

Explore the universe of human proteins at neXtProt for TNFAIP6: NX_P98066

Explore proteomics data for TNFAIP6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn118, Asn258
  • Modification sites at PhosphoSitePlus

  • See TNFAIP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009046.2  
    ENSEMBL proteins: 
     ENSP00000243347  

    TNFAIP6 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TNFAIP6
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    Novus Biologicals TNFAIP6 Protein
    Novus Biologicals TNFAIP6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TNFAIP6 

     
    antibodies-online proteins for TNFAIP6 (5 products) 

     
    antibodies-online peptides for TNFAIP6

    TNFAIP6 Antibody Products:

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    Abcam antibodies for TNFAIP6
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    ThermoFisher Antibodies for TNFAIP6
    antibodies-online antibodies for TNFAIP6 (19 products) 

    TNFAIP6 Assay Products:

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    antibodies-online kits for TNFAIP6 (21 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000859 CUB_dom
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR000538 Link

    Graphical View of Domain Structure for InterPro Entry P98066

    ProtoNet protein and cluster: P98066

    2 Blocks protein domains:
    IPB000538 Link domain
    IPB000859 CUB domain


    UniProtKB/Swiss-Prot: TSG6_HUMAN, P98066
    Similarity: Contains 1 CUB domain
    Similarity: Contains 1 Link domain


    Find genes that share domains with TNFAIP6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSG6_HUMAN, P98066
    Function: Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis
    Induction: By TNF

         Genatlas biochemistry entry for TNFAIP6:
    tumor necrosis factor,alpha-induced protein 6

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005540hyaluronic acid binding IEA--
         
    Find genes that share ontologies with TNFAIP6           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tnfaip6):
     endocrine/exocrine gland  immune system  reproductive system  respiratory system 

    Find genes that share phenotypes with TNFAIP6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tnfaip6tm1Cful for TNFAIP6

       genOway: Develop your customized and physiologically relevant rodent model for TNFAIP6

    miRNA
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    Block miRNA regulation of human, mouse, rat TNFAIP6 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TNFAIP6:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidTNFAIP6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TNFAIP6

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TNFAIP6 (NM_007115)
    Sino Biological Human cDNA Clone for TNFAIP6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFAIP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFAIP6

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    cytoskeleton1
    cytosol1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFAIP6 About    
    See pathways by source

    SuperPathContained pathways About
    1Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    2PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    3ERK Signaling
    Molecular Mechanisms of Cancer0.51
    4PEDF Induced Signaling
    STAT3 Pathway0.47

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFAIP6 (see all 6)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling



        Pathway & Disease-focused RT2 Profiler PCR Array including TNFAIP6: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFAIP6

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for TNFAIP6 (P980663 ENSP000002433474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    THBS1P079963, ENSP000002603564I2D: score=1 STRING: ENSP00000260356
    --E7EX883I2D: score=2 
    --ENSP000002681344STRING: ENSP00000268134
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response TAS1730767
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS1730767
    GO:0007267cell-cell signaling TAS1730767

    Find genes that share ontologies with TNFAIP6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    3 ApexBio Compounds for TNFAIP6     About this table
    CompoundAction CAS #
    Lenalidomide (CC-5013)TNF-alfa secretion inhibitor with IC50 of 13 nM[191732-72-6]
    Necrostatin-1Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-alfa-induced necroptosis with EC50 of 490 nM[4311-88-0]
    Pomalidomide (CC-4047)Pomalidomide, previously known as CC-4047 or actimid, is a potent immunomodulatory molecule that exhibits antineoplastic activity for the treatment of hematological malignancies, especially relapsed and refractory multiple myeloma (MM)[19171-19-8]

    Browse Tocris compounds for TNFAIP6 (TSG6)

    1 HMDB Compound for TNFAIP6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronic acidhyaluronic acid 9004-61-9--

    9 Novoseek inferred chemical compound relationships for TNFAIP6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycosaminoglycan 60.8 5 9237673 (1), 18820257 (1)
    chondroitin sulfate 59.4 11 16768462 (3), 16289010 (2), 17635118 (1), 15840581 (1)
    hyaluronic acid 44.2 4 1710472 (1), 11943733 (1), 2210971 (1)
    heparin 33 7 15917224 (2), 18226512 (1), 15183770 (1)
    serine 19.9 6 9244409 (2), 8568267 (1), 12401803 (1), 12692188 (1) (see all 5)
    pge2 12.7 9 11943733 (6)
    calcium 0 5 14723873 (2), 12622693 (1), 16006654 (1), 18226512 (1)
    tyrosine 0 1 15718240 (1)
    dexamethasone 0 1 8568267 (1)



    Find genes that share compounds with TNFAIP6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNFAIP6 gene: 
    NM_007115.3  

    Unigene Cluster for TNFAIP6:

    Tumor necrosis factor, alpha-induced protein 6
    Hs.437322  [show with all ESTs]
    Unigene Representative Sequence: NM_007115
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000243347(uc002txk.3) ENST00000460812
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TNFAIP6 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TNFAIP6:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidTNFAIP6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TNFAIP6
    Predesigned siRNA for gene silencing in human, mouse, rat TNFAIP6
    Clone
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    GenScript: all cDNA clones in your preferred vector: TNFAIP6 (NM_007115)
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    Primer
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    OriGene qPCR primer pairs and template standards for TNFAIP6
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNFAIP6
      QuantiTect SYBR Green Assays in human, mouse, rat TNFAIP6
      QuantiFast Probe-based Assays in human, mouse, rat TNFAIP6

    Additional mRNA sequence: 

    AF086484.1 AJ419936.1 AJ421518.1 BC030205.1 M31164.1 M31165.1 

    4 DOTS entries:

    DT.312975  DT.120976147  DT.40110898  DT.75161440 

    Selected AceView cDNA sequences (see all 70):

    BC030205 AW020995 CD366440 CA308497 CA415298 W93163 AA039722 AF086484 
    AI865870 AJ419936 AI225126 NM_007115 BI491954 AA507959 AU098413 AA448801 
    AJ421518 BQ230041 BV202956 W92764 BI755270 AI168135 BQ575738 AI950438 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFAIP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTAAACA
    TNFAIP6 Expression
    About this image


    TNFAIP6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
    TNFAIP6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFAIP6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437322

    UniProtKB/Swiss-Prot: TSG6_HUMAN, P98066
    Tissue specificity: Found in the synovial fluid of patients with rheumatoid arthritis

        Pathway & Disease-focused RT2 Profiler PCR Array including TNFAIP6: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TNFAIP6
    OriGene qSTAR qPCR primer pairs in human, mouse for TNFAIP6
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    QuantiFast Probe-based Assays in human, mouse, rat TNFAIP6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFAIP6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfaip61 , 5 tumor necrosis factor alpha induced protein 61, 5 88.26(n)1
    92.8(a)1
      2 (29.98 cM)5
    219301  NM_009398.21  NP_033424.11 
     520380095 
    chicken
    (Gallus gallus)
    Aves TNFAIP61 tumor necrosis factor, alpha-induced protein 6 77.52(n)
    82.38(a)
      424315  NM_001037837.2  NP_001032926.2 
    lizard
    (Anolis carolinensis)
    Reptilia TNFAIP66
    tumor necrosis factor, alpha-induced protein 6
    64(a)
    1 ↔ 1
    GL343302.1(1289228-1317113)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tnfaip61 tumor necrosis factor, alpha-induced protein 6 69.46(n)
    74.9(a)
      100490996  XM_002936659.2  XP_002936705.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.177382 Transcribed sequence with weak similarity to protein more 74.88(n)    BQ615550.1 


    ENSEMBL Gene Tree for TNFAIP6 (if available)
    TreeFam Gene Tree for TNFAIP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNFAIP6 gene
    STAB22  STAB12  

    Find genes that share paralogs with TNFAIP6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFAIP6 (see all 464)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs109305761,2
    C,F,H--152212156(+) ACTTAC/AATCAT 1 -- us2k111Minor allele frequency- A:0.10NA EA NS CSA WA 656
    rs1135372381,2
    C,F--152212310(+) CAAAGC/AAACTC 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1497844911,2
    --152212357(+) ACTTCA/GCTCTA 1 -- us2k10--------
    rs37554791,2
    C--152212399(+) AGAAGG/TGTATC 1 -- us2k15Minor allele frequency- T:0.09EA CSA WA NA 1856
    rs1450819521,2
    C--152212412(+) TTCTTA/TGTTAT 1 -- us2k10--------
    rs1881027801,2
    C--152212663(+) TCATGA/GTTTAT 1 -- us2k10--------
    rs1491150371,2
    C--152212681(+) AACTAC/TCTATG 1 -- us2k10--------
    rs124673891,2
    C,F,H--152212957(+) AACACG/ACCTGA 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1431087131,2
    --152213063(+) GGAGGG/TACTAA 1 -- us2k10--------
    rs1478303451,2
    --152213088(+) AATGAA/GTGCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TNFAIP6 (152214106 - 152236562 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TNFAIP6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2972CNV Insertion18451855
    esv34659CNV Loss17911159
    nsv834418CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600410    OMIM disorders: --

    4 diseases for TNFAIP6:    
    About MalaCards
    osteoarthritis    chronic active epstein-barr virus infection    rheumatoid arthritis    arthritis


    Find genes that share disorders with TNFAIP6           About GenesLikeMe

    7 Novoseek inferred disease relationships for TNFAIP6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 64 71 7935377 (2), 11145024 (2), 16547399 (2), 8454591 (2) (see all 47)
    arthritis 51.4 31 12355494 (6), 8245487 (5), 11145024 (3), 18586671 (2) (see all 11)
    inflammation 44.3 31 8568267 (3), 9244409 (2), 15110797 (2), 12692188 (2) (see all 19)
    tumors 42.5 66 16467113 (3), 7935377 (2), 11145024 (2), 16547399 (2) (see all 41)
    rheumatoid arthritis 36.4 7 11145024 (1), 8245487 (1), 8568267 (1), 11178946 (1) (see all 7)
    osteoarthritis 18.1 2 11178946 (1), 11854277 (1)
    asthma 0 2 17307731 (1), 16873769 (1)

    Genetic Association Database (GAD): TNFAIP6
    Human Genome Epidemiology (HuGE) Navigator: TNFAIP6 (6 documents)

    Export disorders for TNFAIP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFAIP6 gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with TNFAIP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44. (PubMed id 1730767)1, 2, 3, 9 Lee T.H.... Vilcek J. (J. Cell Biol. 1992)
    2. A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression. (PubMed id 11854277)1, 2, 4, 9 Nentwich H.A.... Day A.J. (J. Biol. Chem. 2002)
    3. TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo. (PubMed id 8568267)1, 3, 9 Wisniewski H.G....Cronstein B.N. (J. Immunol. 1996)
    4. TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor. (PubMed id 7516184)1, 2, 9 Wisniewski H.-G.... Vilcek J. (Biochemistry 1994)
    5. TSG-6 modulates the interaction between hyaluronan and cell surface CD44. (PubMed id 15060082)1, 3, 9 Lesley J....Mikecz K. (J. Biol. Chem. 2004)
    6. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    7. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    8. Polymorphisms in the tumour necrosis factor alpha-induced protein 3 (TNFAIP3) gene are associated with chronic rhinosinusitis. (PubMed id 19344623)1, 4 Cormier C....Desrosiers M. (amp 2009)
    9. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. (PubMed id 16453284)1, 4 Valdes A.M....Spector T.D. (Arthritis Rheum. 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7130 HGNC: 11898 AceView: TNFAIP6 Ensembl:ENSG00000123610 euGenes: HUgn7130
    ECgene: TNFAIP6 H-InvDB: TNFAIP6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNFAIP6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFAIP6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFAIP6 gene:
    Search GeneIP for patents involving TNFAIP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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