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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFAIP6 Gene

protein-coding   GIFtS: 56
GCID: GC02P152178

Tumor Necrosis Factor, Alpha-Induced Protein 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Necrosis Factor, Alpha-Induced Protein 61 2     TNF-Stimulated Gene 6 Protein2 3
Hyaluronate-Binding Protein2 3     Tumor Necrosis Factor Alpha-Inducible Protein 62
TSG-62 3     Tumor Necrosis Factor-Inducible Gene 6 Protein2
TSG62 3     Tumor Necrosis Factor-Stimulated Gene-6 Protein2
TNF Alpha-Induced Protein 62 3     Tumor Necrosis Factor Alpha-Induced Protein 63

External Ids:    HGNC: 118981   Entrez Gene: 71302   Ensembl: ENSG000001236107   OMIM: 6004105   UniProtKB: P980663   

Export aliases for TNFAIP6 gene to outside databases

Previous GC identifers: GC02P149908 GC02P150743 GC02P152416 GC02P152039 GC02P151922 GC02P144110


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFAIP6 Gene:
The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a
member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in
extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with
inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which
is important in the protease network associated with inflammation. This gene can be induced by proinflammatory
cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the
synovial fluid of patients with osteoarthritis and rheumatoid arthritis.(provided by RefSeq, Dec 2010)

GeneCards Summary for TNFAIP6 Gene: 
TNFAIP6 (tumor necrosis factor, alpha-induced protein 6) is a protein-coding gene. Diseases associated with TNFAIP6 include osteoarthritis, and chronic active epstein-barr virus infection, and among its related super-pathways are Akt Signaling and PAK Pathway. GO annotations related to this gene include hyaluronic acid binding. An important paralog of this gene is STAB2.

UniProtKB/Swiss-Prot: TSG6_HUMAN, P98066
Function: Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis

Gene Wiki entry for TNFAIP6 (TSG-6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFAIP6 gene promoter:
         STAT1   STAT4   STAT1beta   NF-kappaB   STAT1alpha   NF-kappaB2   STAT2   STAT3   NF-kappaB1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFAIP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFAIP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFAIP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23.3   Ensembl cytogenetic band:  2q23.3   HGNC cytogenetic band: 2q23.3

TNFAIP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFAIP6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P152178:  view genomic region     (about GC identifiers)

Start:
152,214,106 bp from pter      End:
152,236,562 bp from pter
Size:
22,457 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TSG6_HUMAN, P98066 (See protein sequence)
Recommended Name: Tumor necrosis factor-inducible gene 6 protein precursor  
Size: 277 amino acids; 31203 Da
Subunit: Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability
of the complex
4 PDB 3D structures from and Proteopedia for TNFAIP6:
1O7B (3D)        1O7C (3D)        2PF5 (3D)        2WNO (3D)    
Secondary accessions: Q53TI7 Q8WWI9

Explore the universe of human proteins at neXtProt for TNFAIP6: NX_P98066

Explore proteomics data for TNFAIP6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P98066

  • TNFAIP6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNFAIP6 Protein Expression
    REFSEQ proteins: NP_009046.2  
    ENSEMBL proteins: 
     ENSP00000243347  

    Human Recombinant Protein Products for TNFAIP6: 
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    Novus Biologicals TNFAIP6 Protein
    Novus Biologicals TNFAIP6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 


    TNFAIP6 Antibody Products: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR000859 CUB_dom
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR000538 Link

    Graphical View of Domain Structure for InterPro Entry P98066

    ProtoNet protein and cluster: P98066

    2 Blocks protein domains:
    IPB000538 Link domain
    IPB000859 CUB domain


    UniProtKB/Swiss-Prot: TSG6_HUMAN, P98066
    Similarity: Contains 1 CUB domain
    Similarity: Contains 1 Link domain


    TNFAIP6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSG6_HUMAN, P98066
    Function: Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis
    Induction: By TNF

         Genatlas biochemistry entry for TNFAIP6:
    tumor necrosis factor,alpha-induced protein 6

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005540hyaluronic acid binding IEA--
         
    TNFAIP6 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tnfaip6):
     endocrine/exocrine gland  reproductive system 

    TNFAIP6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tnfaip6tm1Cful for TNFAIP6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNFAIP6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNFAIP6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFAIP6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFAIP6 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFAIP6
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFAIP6:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidTNFAIP6 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNFAIP6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    2PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    3Rho Family GTPases
    Molecular Mechanisms of Cancer0.51
    4PEDF Induced Signaling
    STAT3 Pathway0.47

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFAIP6 (see all 6)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFAIP6

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for TNFAIP6 (P980663 ENSP000002433474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    THBS1P079963, ENSP000002603564I2D: score=1 STRING: ENSP00000260356
    --E7EX883I2D: score=2 
    --ENSP000002681344STRING: ENSP00000268134
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response TAS1730767
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS1730767
    GO:0007267cell-cell signaling TAS1730767

    TNFAIP6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNFAIP6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFAIP6 (TSG6)

    1 HMDB Compound for TNFAIP6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronic acidhyaluronic acid 9004-61-9--

    9 Novoseek inferred chemical compound relationships for TNFAIP6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycosaminoglycan 60.8 5 9237673 (1), 18820257 (1)
    chondroitin sulfate 59.4 11 16768462 (3), 16289010 (2), 17635118 (1), 15840581 (1)
    hyaluronic acid 44.2 4 1710472 (1), 11943733 (1), 2210971 (1)
    heparin 33 7 15917224 (2), 18226512 (1), 15183770 (1)
    serine 19.9 6 9244409 (2), 8568267 (1), 12401803 (1), 12692188 (1) (see all 5)
    pge2 12.7 9 11943733 (6)
    calcium 0 5 14723873 (2), 12622693 (1), 16006654 (1), 18226512 (1)
    tyrosine 0 1 15718240 (1)
    dexamethasone 0 1 8568267 (1)

    Search CenterWatch for drugs/clinical trials and news about TNFAIP6 / TSG6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNFAIP6 gene: 
    NM_007115.3  

    Unigene Cluster for TNFAIP6:

    Tumor necrosis factor, alpha-induced protein 6
    Hs.437322  [show with all ESTs]
    Unigene Representative Sequence: NM_007115
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000243347(uc002txk.3) ENST00000460812
    miRNA
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    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidTNFAIP6 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TNFAIP6 (NM_007115)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFAIP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFAIP6
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFAIP6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFAIP6

    Additional mRNA sequence: 

    AF086484.1 AJ419936.1 AJ421518.1 BC030205.1 M31164.1 M31165.1 

    4 DOTS entries:

    DT.312975  DT.120976147  DT.40110898  DT.75161440 

    24/70 AceView cDNA sequences (see all 70):

    AI865870 AI225126 AF086484 NM_007115 CA415298 BI491954 AU098413 AA507959 
    AW020995 AA039722 AJ419936 CA308497 W93163 BC030205 CD366440 AA448801 
    AI950438 CD369984 CA307493 BM908074 AW469420 BQ575738 BQ230041 AA628236 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFAIP6 expression in normal human tissues (normalized intensities)      TNFAIP6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTAAACA
    TNFAIP6 Expression
    About this image


    TNFAIP6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Cardiac Fibroblasts Myocardium
             Human Cardiac Myocytes-adult (HCM-a)   
             Cardiac Myocytes   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Fibroblast
             Human Prostate Fibroblasts (HPrF)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Wharton's jelly-derived stem cells
             Human Umbilical Mesenchymal Stem Cells (HUMSC)   

    See TNFAIP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFAIP6

    SOURCE GeneReport for Unigene cluster: Hs.437322

    UniProtKB/Swiss-Prot: TSG6_HUMAN, P98066
    Tissue specificity: Found in the synovial fluid of patients with rheumatoid arthritis

        SABiosciences Expression via Pathway-Focused PCR Array including TNFAIP6: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFAIP6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TNFAIP6 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfaip61 , 5 tumor necrosis factor alpha induced protein 61, 5 87.52(n)1
    90.91(a)1
      2 (29.98 cM)5
    219301  NM_009398.21  NP_033424.11 
     520380095 
    chicken
    (Gallus gallus)
    Aves TNFAIP61 tumor necrosis factor, alpha-induced protein 6 77.08(n)
    81.25(a)
      424315  NM_001037837.2  NP_001032926.2 
    lizard
    (Anolis carolinensis)
    Reptilia TNFAIP66
    Uncharacterized protein
    66(a)
    1 ↔ 1
    GL343302.1(1289228-1317113)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.177382 Transcribed sequence with weak similarity to protein more 74.88(n)    BQ615550.1 


    ENSEMBL Gene Tree for TNFAIP6 (if available)
    TreeFam Gene Tree for TNFAIP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFAIP6 gene
    STAB22  STAB12  

    TNFAIP6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/464 SNPs in TNFAIP6 are shown (see all 464)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0130054
    ----see VAR_0130052 Q R mis40--------
    rs109305761,2
    C,F,H--152212156(+) ACTTAC/AATCAT 1 -- us2k111Minor allele frequency- A:0.10NA EA NS CSA WA 656
    rs1135372381,2
    C,F--152212310(+) CAAAGC/AAACTC 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1497844911,2
    --152212357(+) ACTTCA/GCTCTA 1 -- us2k10--------
    rs37554791,2
    C--152212399(+) AGAAGG/TGTATC 1 -- us2k15Minor allele frequency- T:0.09EA CSA WA NA 1856
    rs1450819521,2
    C--152212412(+) TTCTTA/TGTTAT 1 -- us2k10--------
    rs1881027801,2
    C--152212663(+) TCATGA/GTTTAT 1 -- us2k10--------
    rs1491150371,2
    C--152212681(+) AACTAC/TCTATG 1 -- us2k10--------
    rs124673891,2
    C,F,H--152212957(+) AACACG/ACCTGA 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1431087131,2
    --152213063(+) GGAGGG/TACTAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TNFAIP6 (152214106 - 152236562 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TNFAIP6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2972CNV Insertion18451855
    esv34659CNV Loss17911159
    nsv834418CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600410    OMIM disorders: --

    18 diseases for TNFAIP6:    About MalaCards
    osteoarthritis    chronic active epstein-barr virus infection    dermatofibrosarcoma protuberans    dermatofibrosarcoma
    rheumatoid arthritis    arthritis    kawasaki disease    keratoconus
    keloids    hepatitis b    colorectal cancer    ovarian cancer
    cervicitis    hepatitis    adenocarcinoma    endotheliitis
    leukemia    prostatitis


    TNFAIP6 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for TNFAIP6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 64 71 7935377 (2), 11145024 (2), 16547399 (2), 8454591 (2) (see all 47)
    arthritis 51.4 31 12355494 (6), 8245487 (5), 11145024 (3), 18586671 (2) (see all 11)
    inflammation 44.3 31 8568267 (3), 9244409 (2), 15110797 (2), 12692188 (2) (see all 19)
    tumors 42.5 66 16467113 (3), 7935377 (2), 11145024 (2), 16547399 (2) (see all 41)
    rheumatoid arthritis 36.4 7 11145024 (1), 8245487 (1), 8568267 (1), 11178946 (1) (see all 7)
    osteoarthritis 18.1 2 11178946 (1), 11854277 (1)
    asthma 0 2 17307731 (1), 16873769 (1)

    Genetic Association Database (GAD): TNFAIP6
    Human Genome Epidemiology (HuGE) Navigator: TNFAIP6 (6 documents)

    Export disorders for TNFAIP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFAIP6 gene, integrated from 9 sources (see all 115):
    (articles sorted by number of sources associating them with TNFAIP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44. (PubMed id 1730767)1, 2, 3, 9 Lee T.H.... Vilcek J. (1992)
    2. A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression. (PubMed id 11854277)1, 2, 4, 9 Nentwich H.A.... Day A.J. (2002)
    3. TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo. (PubMed id 8568267)1, 3, 9 Wisniewski H.G....Cronstein B.N. (1996)
    4. TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor. (PubMed id 7516184)1, 2, 9 Wisniewski H.-G.... Vilcek J. (1994)
    5. TSG-6 modulates the interaction between hyaluronan and cell surface CD44. (PubMed id 15060082)1, 3, 9 Lesley J....Mikecz K. (2004)
    6. Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (2010)
    7. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    8. Polymorphisms in the tumour necrosis factor alpha-induced protein 3 (TNFAIP3) gene are associated with chronic rhinosinusitis. (PubMed id 19344623)1, 4 Cormier C....Desrosiers M. (2009)
    9. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. (PubMed id 16453284)1, 4 Valdes A.M....Spector T.D. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7130 HGNC: 11898 AceView: TNFAIP6 Ensembl:ENSG00000123610 euGenes: HUgn7130
    ECgene: TNFAIP6 H-InvDB: TNFAIP6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFAIP6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFAIP6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNFAIP6 gene:
    Search GeneIP for patents involving TNFAIP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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