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Aliases for TNFAIP2 Gene

Aliases for TNFAIP2 Gene

  • TNF Alpha Induced Protein 2 2 3 5
  • Tumor Necrosis Factor, Alpha-Induced Protein 2 2 3
  • Exocyst Complex Component 3-Like 3 2 3
  • Primary Response Gene B94 Protein 3 4
  • TNF Alpha-Induced Protein 2 3 4
  • Tumor Necrosis Factor, Alpha Induced Protein 2 3
  • EXOC3L3 3
  • B94 3

External Ids for TNFAIP2 Gene

Previous GeneCards Identifiers for TNFAIP2 Gene

  • GC14P100983
  • GC14P097408
  • GC14P101579
  • GC14P101582
  • GC14P102662
  • GC14P103592
  • GC14P083771

Summaries for TNFAIP2 Gene

Entrez Gene Summary for TNFAIP2 Gene

  • This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFAIP2 Gene

TNFAIP2 (TNF Alpha Induced Protein 2) is a Protein Coding gene. Diseases associated with TNFAIP2 include Primary Mediastinal Large B-Cell Lymphoma. GO annotations related to this gene include SNARE binding. An important paralog of this gene is EXOC3.

UniProtKB/Swiss-Prot for TNFAIP2 Gene

  • May play a role as a mediator of inflammation and angiogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFAIP2 Gene

Genomics for TNFAIP2 Gene

Regulatory Elements for TNFAIP2 Gene

Enhancers for TNFAIP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TNFAIP2 on UCSC Golden Path with GeneCards custom track

Promoters for TNFAIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNFAIP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNFAIP2 Gene

103,121,147 bp from pter
103,137,439 bp from pter
16,293 bases
Plus strand

Genomic View for TNFAIP2 Gene

Genes around TNFAIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFAIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFAIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP2 Gene

Proteins for TNFAIP2 Gene

  • Protein details for TNFAIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor alpha-induced protein 2
    Protein Accession:
    Secondary Accessions:
    • Q86VI0

    Protein attributes for TNFAIP2 Gene

    654 amino acids
    Molecular mass:
    72661 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TNFAIP2 Gene

Proteomics data for TNFAIP2 Gene at MOPED

Post-translational modifications for TNFAIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for TNFAIP2 Gene

Domains & Families for TNFAIP2 Gene

Protein Domains for TNFAIP2 Gene


Suggested Antigen Peptide Sequences for TNFAIP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SEC6 family.
  • Belongs to the SEC6 family.
genes like me logo Genes that share domains with TNFAIP2: view

No data available for Gene Families for TNFAIP2 Gene

Function for TNFAIP2 Gene

Molecular function for TNFAIP2 Gene

GENATLAS Biochemistry:
tumor necrosis factor alpha,inducible primary response,2
UniProtKB/Swiss-Prot Function:
May play a role as a mediator of inflammation and angiogenesis.
UniProtKB/Swiss-Prot Induction:
By TNF and other proinflammatory factors.
genes like me logo Genes that share phenotypes with TNFAIP2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFAIP2 Gene

Localization for TNFAIP2 Gene

Subcellular locations from

Jensen Localization Image for TNFAIP2 Gene COMPARTMENTS Subcellular localization image for TNFAIP2 gene
Compartment Confidence
extracellular 4
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TNFAIP2 Gene

Pathways & Interactions for TNFAIP2 Gene

SuperPathways for TNFAIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TNFAIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
genes like me logo Genes that share ontologies with TNFAIP2: view

No data available for Pathways by source and SIGNOR curated interactions for TNFAIP2 Gene

Drugs & Compounds for TNFAIP2 Gene

(2) Additional Compounds for TNFAIP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFAIP2: view

Transcripts for TNFAIP2 Gene

Unigene Clusters for TNFAIP2 Gene

Tumor necrosis factor, alpha-induced protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP3: -

Relevant External Links for TNFAIP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFAIP2 Gene

mRNA expression in normal human tissues for TNFAIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFAIP2 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for TNFAIP2 Gene

This gene is overexpressed in Lymph node (8.1), Spleen (7.9), and Bone (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNFAIP2 Gene

SOURCE GeneReport for Unigene cluster for TNFAIP2 Gene Hs.525607

genes like me logo Genes that share expression patterns with TNFAIP2: view

Protein tissue co-expression partners for TNFAIP2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TNFAIP2 Gene

Orthologs for TNFAIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNFAIP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNFAIP2 35
  • 84.15 (n)
  • 76.31 (a)
  • 73 (a)
(Canis familiaris)
Mammalia TNFAIP2 35
  • 85.68 (n)
  • 77.95 (a)
  • 74 (a)
(Mus musculus)
Mammalia Tnfaip2 35
  • 80.21 (n)
  • 72.4 (a)
Tnfaip2 16
Tnfaip2 36
  • 68 (a)
(Pan troglodytes)
Mammalia TNFAIP2 35
  • 93.47 (n)
  • 91.58 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tnfaip2 35
  • 79.67 (n)
  • 72.91 (a)
(Monodelphis domestica)
Mammalia TNFAIP2 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia TNFAIP2 36
  • 44 (a)
(Gallus gallus)
Aves TNFAIP2 35
  • 51.2 (n)
  • 41.86 (a)
  • 36 (a)
(Anolis carolinensis)
Reptilia TNFAIP2 36
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfaip2 35
  • 45.29 (n)
  • 37.21 (a)
(Danio rerio)
Actinopterygii tnfaip2b 35
  • 44.47 (n)
  • 32.04 (a)
tnfaip2a 36
  • 23 (a)
tnfaip2b 36
  • 27 (a)
tnfaip2b 36
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec6 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea sec-6 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
Species with no ortholog for TNFAIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNFAIP2 Gene

Gene Tree for TNFAIP2 (if available)
Gene Tree for TNFAIP2 (if available)

Paralogs for TNFAIP2 Gene

Paralogs for TNFAIP2 Gene

genes like me logo Genes that share paralogs with TNFAIP2: view

Variants for TNFAIP2 Gene

Sequence variations from dbSNP and Humsavar for TNFAIP2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1132339 - 103,127,613(+) GGGTG(A/C/G)AGAAC reference, missense
rs2229727 - 103,133,510(+) CTGCA(C/T)CCAGC reference, missense
rs2234146 - 103,133,719(+) CCCTA(C/T)GCTGG reference, missense
rs710100 -- 103,135,941(-) TCTAA(C/T)GCTGG reference, missense, utr-variant-3-prime
rs749205 -- 103,131,188(+) GAGTC(A/G)CTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFAIP2 Gene

Variant ID Type Subtype PubMed ID
nsv832882 CNV Loss 17160897
nsv902264 CNV Loss 21882294
nsv9168 CNV Loss 18304495
dgv1986n71 CNV Loss 21882294
nsv902267 CNV Loss 21882294
nsv902268 CNV Loss 21882294
dgv1987n71 CNV Loss 21882294
dgv1988n71 CNV Loss 21882294
nsv902275 CNV Loss 21882294
nsv902276 CNV Gain+Loss 21882294
dgv1989n71 CNV Loss 21882294
nsv902280 CNV Gain+Loss 21882294
nsv902282 CNV Gain+Loss 21882294
dgv1990n71 CNV Loss 21882294
nsv902284 CNV Gain 21882294
nsv902286 CNV Gain 21882294
nsv902287 CNV Gain 21882294
nsv902289 CNV Gain+Loss 21882294
esv2749162 CNV Deletion 23290073
esv2387988 CNV Deletion 18987734
nsv84629 CNV Loss 16902084
esv995383 CNV Deletion 20482838
esv1662663 CNV Deletion 17803354
nsv84480 CNV Loss 16902084
nsv902290 CNV Loss 21882294

Variation tolerance for TNFAIP2 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFAIP2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFAIP2 Gene

Disorders for TNFAIP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TNFAIP2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
primary mediastinal large b-cell lymphoma
  • large cell lymphoma of the mediastinum
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFAIP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TNFAIP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFAIP2 Gene

Publications for TNFAIP2 Gene

  1. Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro. (PMID: 1374453) Sarma V. … Dixit V.M. (J. Immunol. 1992) 2 3 4 23 67
  2. Identification of B94 (TNFAIP2) as a potential retinoic acid target gene in acute promyelocytic leukemia. (PMID: 10766166) Rusiniak M.E. … Slack J.L. (Cancer Res. 2000) 3 23
  3. NF-I_B-mediated transcriptional upregulation of TNFAIP2 by the Epstein-Barr virus oncoprotein, LMP1, promotes cell motility in nasopharyngeal carcinoma. (PMID: 23975427) Chen C.C. … Chang Y.S. (Oncogene 2014) 3
  4. A Functional TNFAIP2 3'-UTR rs8126 Genetic Polymorphism Contributes to Risk of Esophageal Squamous Cell Carcinoma. (PMID: 25383966) Zhang J. … Zhou L. (PLoS ONE 2014) 3
  5. Proteomic analysis of the NOS2 interactome in human airway epithelial cells. (PMID: 23438482) Foster M.W. … Marshall H.E. (Nitric Oxide 2013) 3

Products for TNFAIP2 Gene

Sources for TNFAIP2 Gene