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TNFAIP2 Gene

protein-coding   GIFtS: 57
GCID: GC14P103592

Tumor Necrosis Factor, Alpha-Induced Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor, Alpha-Induced Protein 21 2     B942
Exocyst Complex Component 3-Like 31 2     EXOC3L32
Primary Response Gene B94 Protein2 3     Tumor Necrosis Factor Alpha-Induced Protein 22
TNF Alpha-Induced Protein 22 3     

External Ids:    HGNC: 118951   Entrez Gene: 71272   Ensembl: ENSG000001852157   OMIM: 6033005   UniProtKB: Q031693   

Export aliases for TNFAIP2 gene to outside databases

Previous GC identifers: GC14P100983 GC14P097408 GC14P101579 GC14P101582 GC14P102662 GC14P083771


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFAIP2 Gene:
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in
umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell
line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this
gene may be a retinoic acid target gene in acute promyelocytic leukemia. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFAIP2 Gene:
TNFAIP2 (tumor necrosis factor, alpha-induced protein 2) is a protein-coding gene. Diseases associated with TNFAIP2 include mediastinitis, and primary mediastinal large b-cell lymphoma. An important paralog of this gene is EXOC3L2.

UniProtKB/Swiss-Prot: TNAP2_HUMAN, Q03169
Function: May play a role as a mediator of inflammation and angiogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFAIP2 gene promoter:
         SRF   GR   HSF1 (long)   Lmo2   Tal-1beta   CRE-BP1   c-Myb   HSF1short   GR-alpha   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFAIP2 promoter sequence
   Search Chromatin IP Primers for TNFAIP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFAIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.32   HGNC cytogenetic band: 14q32

TNFAIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFAIP2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P103592:  view genomic region     (about GC identifiers)

Start:
103,589,779 bp from pter      End:
103,603,776 bp from pter
Size:
13,998 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TNAP2_HUMAN, Q03169 (See protein sequence)
Recommended Name: Tumor necrosis factor alpha-induced protein 2  
Size: 654 amino acids; 72661 Da
Developmental stage: Differentially expressed in development and capillary tube-like formation in vitro
Secondary accessions: Q86VI0

Explore the universe of human proteins at neXtProt for TNFAIP2: NX_Q03169

Explore proteomics data for TNFAIP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TNFAIP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006282.2  
    ENSEMBL proteins: 
     ENSP00000453103   ENSP00000452634   ENSP00000452824   ENSP00000452992   ENSP00000453142  
     ENSP00000453458   ENSP00000452914   ENSP00000332326   ENSP00000393256   ENSP00000446171  

    TNFAIP2 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR010326 Sec6

    Graphical View of Domain Structure for InterPro Entry Q03169

    ProtoNet protein and cluster: Q03169

    1 Blocks protein domain: IPB010326 Exocyst complex component Sec6

    UniProtKB/Swiss-Prot: TNAP2_HUMAN, Q03169
    Similarity: Belongs to the SEC6 family


    TNFAIP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNAP2_HUMAN, Q03169
    Function: May play a role as a mediator of inflammation and angiogenesis
    Induction: By TNF and other proinflammatory factors

         Genatlas biochemistry entry for TNFAIP2:
    tumor necrosis factor alpha,inducible primary response,2

    Phenotypes:
         3 GenomeRNAi human phenotypes for TNFAIP2:
     Decreased Hepatitis C virus re  Increased HPV18 LCR reporter a  Upregulation of NF-kappaB path 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFAIP2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFAIP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFAIP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TNFAIP2:
    hsa-mir-335-5p (MIRT018025), hsa-mir-16-5p (MIRT031757), hsa-mir-7-5p (MIRT025752), hsa-mir-155-5p (MIRT020719), hsa-mir-30a-5p (MIRT005196)

    Block miRNA regulation of human, mouse, rat TNFAIP2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TNFAIP2:
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-619
    SwitchGear 3'UTR luciferase reporter plasmidTNFAIP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TNFAIP2
    Predesigned siRNA for gene silencing in human, mouse, rat TNFAIP2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TNFAIP2

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    OriGene clones in human, mouse for TNFAIP2 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: TNFAIP2 (NM_006291)
    Sino Biological Human cDNA Clone for TNFAIP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFAIP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFAIP2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytosol2
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000145exocyst IEA--
    GO:0005615extracellular space TAS1374453

    TNFAIP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TNFAIP2
    Interactions:

        Search GeneGlobe Interaction Network for TNFAIP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNFAIP2 (Q031692 ENSP000003323264) via UniProtKB, MINT, STRING, and/or I2D (see all 579)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOC7Q9UPT52, ENSP000003341004MINT-7947479 STRING: ENSP00000334100
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    ABCF1Q8NE712MINT-7947479
    ABCF3Q9NUQ82MINT-7947479
    ACTBP607092MINT-7947479
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006887exocytosis IEA--
    GO:0030154cell differentiation IEA--

    TNFAIP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    3 ApexBio Compounds for TNFAIP2     About this table
    CompoundAction CAS #
    Lenalidomide (CC-5013)TNF-alfa secretion inhibitor with IC50 of 13 nM[191732-72-6]
    Necrostatin-1Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-alfa-induced necroptosis with EC50 of 490 nM[4311-88-0]
    Pomalidomide (CC-4047)Pomalidomide, previously known as CC-4047 or actimid, is a potent immunomodulatory molecule that exhibits antineoplastic activity for the treatment of hematological malignancies, especially relapsed and refractory multiple myeloma (MM)[19171-19-8]

    Browse Tocris compounds for TNFAIP2 (TNAP2)

    2 Novoseek inferred chemical compound relationships for TNFAIP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cycloheximide 52.9 1 1374453 (1)
    retinoic acid 46.1 9 10766166 (5), 12894236 (1)



    TNFAIP2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TNFAIP2 gene: 
    NM_006291.2  

    Unigene Cluster for TNFAIP2:

    Tumor necrosis factor, alpha-induced protein 2
    Hs.525607  [show with all ESTs]
    Unigene Representative Sequence: NM_006291
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559195(uc001yml.1) ENST00000558056 ENST00000560869 ENST00000560562
    ENST00000559406 ENST00000560428 ENST00000560670 ENST00000561156 ENST00000559255
    ENST00000561217 ENST00000333007(uc001ymm.1 uc010awo.1 uc010txz.1)
    ENST00000451723 ENST00000538222(uc010tya.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TNFAIP2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TNFAIP2:
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-619
    SwitchGear 3'UTR luciferase reporter plasmidTNFAIP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TNFAIP2
    Predesigned siRNA for gene silencing in human, mouse, rat TNFAIP2
    Clone
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    OriGene clones in human, mouse for TNFAIP2 (see all 6)
    OriGene ORF clones in mouse, rat for TNFAIP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNFAIP2 (NM_006291)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFAIP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFAIP2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TNFAIP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNFAIP2
      QuantiTect SYBR Green Assays in human, mouse, rat TNFAIP2
      QuantiFast Probe-based Assays in human, mouse, rat TNFAIP2

    Additional mRNA sequence: 

    AK302929.1 AK303781.1 AK309854.1 AK316496.1 BC128449.1 BC128450.1 M92357.1 

    10 DOTS entries:

    DT.100767834  DT.100752108  DT.91749383  DT.100760394  DT.40115880  DT.92450567  DT.95192578  DT.100752110 
    DT.92005493  DT.97801499 

    Selected AceView cDNA sequences (see all 317):

    AI613435 AW043935 CA309467 R53219 AI141988 BQ917390 CD369581 AW512859 
    BC017818 BM756462 BM747838 AI038093 BQ008377 BQ917320 R75699 AW085836 
    BQ638037 AA315833 CD367735 BM723611 CA487429 BM756411 BQ897589 CA313975 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                                                          
    SP2:                                                                                          
    SP3:        -                                                                                 


    ECgene alternative splicing isoforms for TNFAIP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFAIP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCAGCCCG
    TNFAIP2 Expression
    About this image


    TNFAIP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Monocytes Peripheral Blood
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Heart (Cardiovascular System)
             Endocardial Tube Cells Endocardium
     
     Lung (Respiratory System)
    TNFAIP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFAIP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525607
        Custom PCR Arrays for TNFAIP2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TNFAIP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfaip21 , 5 tumor necrosis factor, alpha-induced protein 21, 5 80.21(n)1
    72.4(a)1
      12 (60.99 cM)5
    219281  NM_009396.21  NP_033422.21 
     1114424695 
    chicken
    (Gallus gallus)
    Aves TNFAIP21 tumor necrosis factor, alpha-induced protein 2 51.2(n)
    41.86(a)
      423477  XM_421383.4  XP_421383.4 
    lizard
    (Anolis carolinensis)
    Reptilia TNFAIP26
    tumor necrosis factor, alpha-induced protein 2
    35(a)
    1 ↔ 1
    GL343232.1(404822-429161)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tnfaip21 tumor necrosis factor, alpha-induced protein 2 45.29(n)
    37.21(a)
      100485899  XM_002937999.2  XP_002938045.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tnfaip2b1 tumor necrosis factor, alpha-induced protein 2b 44.47(n)
    32.04(a)
      569366  XM_692747.5  XP_697839.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta sec66
    sec6
    16(a)
    1 → many
    2R(14512772-14515223)
    worm
    (Caenorhabditis elegans)
    Secernentea sec-66
    Protein SEC-6 (sec-6) mRNA, complete cds
    15(a)
    1 → many
    II(5359552-5372122) WBGene00017284


    ENSEMBL Gene Tree for TNFAIP2 (if available)
    TreeFam Gene Tree for TNFAIP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNFAIP2 gene
    EXOC3L22  EXOC32  EXOC3L12  EXOC3L42  

    TNFAIP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFAIP2 (see all 388)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124358601,2
    H--103590683(+) CACACC/TGAAAG 1 -- us2k10--------
    rs1512928771,2
    --103590685(+) CACCGA/GAAGCG 1 -- us2k10--------
    rs37595731,2
    C,F--103590772(+) CAGGCA/GCTCTG 1 -- us2k116Minor allele frequency- G:0.47NS NA CSA WA EA 1050
    rs81763551,2
    C,F--103590784(+) GTTTCG/ATGTCA 1 -- us2k13Minor allele frequency- A:0.03NS NA 80
    rs1844764421,2
    --103590826(+) TCCTGC/TGGGAG 1 -- us2k10--------
    rs81763561,2
    C,F--103591010(+) GCTCCC/TGCGGG 1 -- us2k111Minor allele frequency- T:0.06NS NA WA 816
    rs1879771901,2
    --103591056(+) AGTTGC/GGGCAC 1 -- us2k10--------
    rs81763571,2
    C,F,H--103591165(+) AGGGAG/AGCCAG 1 -- us2k15Minor allele frequency- A:0.01NS NA 314
    rs749645501,2
    F--103591255(+) CCTGTC/TCCTCA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs81763581,2
    C,F--103591307(+) TGGGGC/ATGGTG 1 -- us2k14Minor allele frequency- A:0.04NS NA 216

    HapMap Linkage Disequilibrium report for TNFAIP2 (103589779 - 103603776 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TNFAIP2 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749162CNV Deletion23290073
    esv1662663CNV Deletion17803354
    esv2387988CNV Deletion18987734
    esv995383CNV Deletion20482838
    nsv9168CNV Loss18304495
    nsv832882CNV Loss17160897
    nsv84480CNV Loss16902084
    nsv902267CNV Loss21882294
    dgv1986n71CNV Loss21882294
    nsv902268CNV Loss21882294

    Human Gene Mutation Database (HGMD): TNFAIP2
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TNFAIP2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603300    OMIM disorders: --

    16 diseases for TNFAIP2:    
    About MalaCards
    mediastinitis    primary mediastinal large b-cell lymphoma    acute promyelocytic leukemia    squamous cell carcinoma of the head and neck
    primary biliary cirrhosis    hepatoblastoma    b-cell lymphomas    endotheliitis
    leukemia    nasopharyngitis    hodgkin's lymphoma    squamous cell carcinoma
    hepatitis b    ovarian cancer    hepatitis    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for TNFAIP2:
    Hepatoblastoma

    TNFAIP2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TNFAIP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 38.9 5 12894236 (1), 17624025 (1), 10766166 (1)
    tumors 8.63 3 12894236 (1), 10766166 (1)

    Genetic Association Database (GAD): TNFAIP2
    Human Genome Epidemiology (HuGE) Navigator: TNFAIP2 (9 documents)

    Export disorders for TNFAIP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFAIP2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with TNFAIP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro. (PubMed id 1374453)1, 2, 3, 9 Sarma V.... Dixit V.M. (J. Immunol. 1992)
    2. SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance. (PubMed id 20157331)1, 4 Edvardsen H....Kristensen V.N. (Pharmacogenomics J. 2010)
    3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PubMed id 19339270)1, 4 Canova C....Brennan P. (Cancer Res. 2009)
    6. Identification of B94 (TNFAIP2) as a potential retinoic acid target gene in acute promyelocytic leukemia. (PubMed id 10766166)1, 9 Rusiniak M.E....Slack J.L. (Cancer Res. 2000)
    7. The miR-184 binding-site rs8126 T&gt;C polymorphism in TNFAIP2 is associated with risk of gastric cancer. (PubMed id 23724109)1 Xu Y....Wei Q. (PLoS ONE 2013)
    8. Proteomic analysis of the NOS2 interactome in human airway epithelial cells. (PubMed id 23438482)1 Foster M.W....Marshall H.E. (Nitric Oxide 2013)
    9. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7127 HGNC: 11895 AceView: TNFAIP2 Ensembl:ENSG00000185215 euGenes: HUgn7127
    ECgene: TNFAIP2 H-InvDB: TNFAIP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNFAIP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFAIP2 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/tnfaip2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFAIP2 gene:
    Search GeneIP for patents involving TNFAIP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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