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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFAIP2 Gene

protein-coding   GIFtS: 58
GCID: GC14P103592

Tumor Necrosis Factor, Alpha-Induced Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Necrosis Factor, Alpha-Induced Protein 21 2     B942
Exocyst Complex Component 3-Like 31 2     EXOC3L32
Primary Response Gene B94 Protein2 3     Tumor Necrosis Factor Alpha-Induced Protein 22
TNF Alpha-Induced Protein 22 3     

External Ids:    HGNC: 118951   Entrez Gene: 71272   Ensembl: ENSG000001852157   OMIM: 6033005   UniProtKB: Q031693   

Export aliases for TNFAIP2 gene to outside databases

Previous GC identifers: GC14P100983 GC14P097408 GC14P101579 GC14P101582 GC14P102662 GC14P083771


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFAIP2 Gene:
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in
umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell
line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this
gene may be a retinoic acid target gene in acute promyelocytic leukemia. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFAIP2 Gene: 
TNFAIP2 (tumor necrosis factor, alpha-induced protein 2) is a protein-coding gene. Diseases associated with TNFAIP2 include acute promyelocytic leukemia, and primary mediastinal large b-cell lymphoma. An important paralog of this gene is EXOC3L2.

UniProtKB/Swiss-Prot: TNAP2_HUMAN, Q03169
Function: May play a role as a mediator of inflammation and angiogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFAIP2 gene promoter:
         SRF   GR   HSF1 (long)   Lmo2   Tal-1beta   CRE-BP1   c-Myb   HSF1short   GR-alpha   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFAIP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFAIP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFAIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.32   HGNC cytogenetic band: 14q32

TNFAIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFAIP2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P103592:  view genomic region     (about GC identifiers)

Start:
103,589,779 bp from pter      End:
103,603,776 bp from pter
Size:
13,998 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNAP2_HUMAN, Q03169 (See protein sequence)
Recommended Name: Tumor necrosis factor alpha-induced protein 2  
Size: 654 amino acids; 72661 Da
Developmental stage: Differentially expressed in development and capillary tube-like formation in vitro
Secondary accessions: Q86VI0

Explore the universe of human proteins at neXtProt for TNFAIP2: NX_Q03169

Explore proteomics data for TNFAIP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q03169

  • TNFAIP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNFAIP2 Protein Expression
    REFSEQ proteins: NP_006282.2  
    ENSEMBL proteins: 
     ENSP00000453103   ENSP00000452634   ENSP00000452824   ENSP00000452992   ENSP00000453142  
     ENSP00000453458   ENSP00000452914   ENSP00000332326   ENSP00000393256   ENSP00000446171  

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    Novus Biologicals TNFAIP2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000145exocyst IEA--
    GO:0005615extracellular space TAS1374453

    TNFAIP2 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR010326 Sec6

    Graphical View of Domain Structure for InterPro Entry Q03169

    ProtoNet protein and cluster: Q03169

    1 Blocks protein domain: IPB010326 Exocyst complex component Sec6

    UniProtKB/Swiss-Prot: TNAP2_HUMAN, Q03169
    Similarity: Belongs to the SEC6 family


    TNFAIP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNAP2_HUMAN, Q03169
    Function: May play a role as a mediator of inflammation and angiogenesis
    Induction: By TNF and other proinflammatory factors

         Genatlas biochemistry entry for TNFAIP2:
    tumor necrosis factor alpha,inducible primary response,2

    Phenotypes:
         3 GenomeRNAi human phenotypes for TNFAIP2:
     Decreased Hepatitis C virus re  Increased HPV18 LCR reporter a  Upregulation of NF-kappaB path 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNFAIP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNFAIP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFAIP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFAIP2 

    miRNA
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    miRTarBase miRNAs that target TNFAIP2:
    hsa-mir-30a (MIRT005196)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFAIP2
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFAIP2:
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-619
    SwitchGear 3'UTR luciferase reporter plasmidTNFAIP2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TNFAIP2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/553 Interacting proteins for TNFAIP2 (Q031692 ENSP000003323264) via UniProtKB, MINT, STRING, and/or I2D (see all 553)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    ABCF1Q8NE712MINT-7947479
    ABCF3Q9NUQ82MINT-7947479
    ACTBP607092MINT-7947479
    ACTL6AO960192MINT-7947479
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006887exocytosis IEA--
    GO:0030154cell differentiation IEA--

    TNFAIP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNFAIP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFAIP2 (TNAP2)

    2 Novoseek inferred chemical compound relationships for TNFAIP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cycloheximide 52.9 1 1374453 (1)
    retinoic acid 46.1 9 10766166 (5), 12894236 (1)

    Search CenterWatch for drugs/clinical trials and news about TNFAIP2 / TNAP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNFAIP2 gene: 
    NM_006291.2  

    Unigene Clusters for TNFAIP2:

    Tumor necrosis factor, alpha-induced protein 2
    Hs.525607  [show with all ESTs], Hs.736562  [show with all ESTs]
    Unigene Representative Sequences: NM_006291, BX346984
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559195(uc001yml.1) ENST00000558056 ENST00000560869 ENST00000560562
    ENST00000559406 ENST00000560428 ENST00000560670 ENST00000561156 ENST00000559255
    ENST00000561217 ENST00000333007(uc001ymm.1 uc010awo.1 uc010txz.1)
    ENST00000451723 ENST00000538222(uc010tya.1)
    miRNA
    Products:
         
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFAIP2:
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-619
    SwitchGear 3'UTR luciferase reporter plasmidTNFAIP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Sirion Biotech Customized lentivirus for stable overexpression of TNFAIP2 
                         Customized lentivirus expression plasmids for stable overexpression of TNFAIP2 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFAIP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFAIP2

    Additional mRNA sequence: BC017818.1 

    10 DOTS entries:

    DT.100767834  DT.100752108  DT.92450567  DT.100760394  DT.91749383  DT.40115880  DT.95192578  DT.97801499 
    DT.100752110  DT.92005493 

    24/317 AceView cDNA sequences (see all 317):

    R53219 BQ685497 BC017818 BI823757 AI038093 BM747838 BU528567 AA082530 
    BQ917320 CR619961 AW512859 AW043935 BE672514 BQ931610 BQ685744 AA315833 
    AI613435 BQ638037 BG289102 BQ689075 BM756411 AI141988 BM723611 BX092264 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                                                          
    SP2:                                                                                          
    SP3:        -                                                                                 


    ECgene alternative splicing isoforms for TNFAIP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFAIP2 expression in normal human tissues (normalized intensities)      TNFAIP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCAGCCCG
    TNFAIP2 Expression
    About this image


    TNFAIP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells
             neutrophils   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Lymph (Hematopoietic System)
             Lymphnode   
     
     Lung (Respiratory System)

    See TNFAIP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFAIP2

    SOURCE GeneReport for Unigene clusters: Hs.525607 Hs.736562
        SABiosciences Custom PCR Arrays for TNFAIP2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TNFAIP2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfaip21 , 5 tumor necrosis factor, alpha-induced protein 21, 5 80.62(n)1
    73.18(a)1
      12 (60.99 cM)5
    219281  NM_009396.21  NP_033422.21 
     1114424695 
    chicken
    (Gallus gallus)
    Aves TNFAIP21 tumor necrosis factor, alpha-induced protein 2 50.47(n)
    39.53(a)
      423477  XM_421383.3  XP_421383.3 
    lizard
    (Anolis carolinensis)
    Reptilia TNFAIP26
    Uncharacterized protein
    34(a)
    1 ↔ 1
    GL343232.1(404822-429161)
    zebrafish
    (Danio rerio)
    Actinopterygii tnfaip2a1 tumor necrosis factor, alpha-induced protein 2a 41.59(n)
    27.77(a)
      567159  NM_001030216.1  NP_001025387.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sec66
    sec6
    15(a)
    1 → many
    2R(14512772-14515223)
    worm
    (Caenorhabditis elegans)
    Secernentea sec-66
    Exocyst complex component 3
    14(a)
    1 → many
    II(5359552-5372122)


    ENSEMBL Gene Tree for TNFAIP2 (if available)
    TreeFam Gene Tree for TNFAIP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFAIP2 gene
    EXOC3L22  EXOC32  EXOC3L12  EXOC3L42  

    TNFAIP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/388 SNPs in TNFAIP2 are shown (see all 388)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124358601,2
    H--103590683(+) CACACC/TGAAAG 1 -- us2k10--------
    rs1512928771,2
    --103590685(+) CACCGA/GAAGCG 1 -- us2k10--------
    rs37595731,2
    C,F--103590772(+) CAGGCA/GCTCTG 1 -- us2k116Minor allele frequency- G:0.47NS NA CSA WA EA 1050
    rs81763551,2
    C,F--103590784(+) GTTTCG/ATGTCA 1 -- us2k13Minor allele frequency- A:0.03NS NA 80
    rs1844764421,2
    --103590826(+) TCCTGC/TGGGAG 1 -- us2k10--------
    rs81763561,2
    C,F--103591010(+) GCTCCC/TGCGGG 1 -- us2k111Minor allele frequency- T:0.06NS NA WA 816
    rs1879771901,2
    --103591056(+) AGTTGC/GGGCAC 1 -- us2k10--------
    rs81763571,2
    C,F,H--103591165(+) AGGGAG/AGCCAG 1 -- us2k15Minor allele frequency- A:0.01NS NA 314
    rs749645501,2
    F--103591255(+) CCTGTC/TCCTCA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs81763581,2
    C,F--103591307(+) TGGGGC/ATGGTG 1 -- us2k14Minor allele frequency- A:0.04NS NA 216

    HapMap Linkage Disequilibrium report for TNFAIP2 (103589779 - 103603776 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/25 variations for TNFAIP2 (see all 25):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749162CNV Deletion23290073
    esv1662663CNV Deletion17803354
    esv2387988CNV Deletion18987734
    esv995383CNV Deletion20482838
    nsv9168CNV Loss18304495
    nsv832882CNV Loss17160897
    nsv84480CNV Loss16902084
    nsv902267CNV Loss21882294
    dgv1986n71CNV Loss21882294
    nsv902268CNV Loss21882294


    Human Gene Mutation Database (HGMD): TNFAIP2
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TNFAIP2
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFAIP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603300    OMIM disorders: --

    15 diseases for TNFAIP2:    About MalaCards
    acute promyelocytic leukemia    primary mediastinal large b-cell lymphoma    mediastinitis    squamous cell carcinoma of the head and neck
    primary biliary cirrhosis    hepatoblastoma    leukemia    endotheliitis
    nasopharyngitis    b-cell lymphomas    hodgkin's lymphoma    squamous cell carcinoma
    hepatitis b    ovarian cancer    hepatitis

    1 disease from the University of Copenhagen DISEASES database for TNFAIP2:
    Hepatoblastoma

    TNFAIP2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TNFAIP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 38.9 5 12894236 (1), 17624025 (1), 10766166 (1)
    tumors 8.63 3 12894236 (1), 10766166 (1)

    Genetic Association Database (GAD): TNFAIP2
    Human Genome Epidemiology (HuGE) Navigator: TNFAIP2 (9 documents)

    Export disorders for TNFAIP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFAIP2 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with TNFAIP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro. (PubMed id 1374453)1, 2, 3, 9 Sarma V.... Dixit V.M. (1992)
    2. SNPs in genes coding for ROS metabolism and signallin g in association with docetaxel clearance. (PubMed id 20157331)1, 4 Edvardsen H....Kristensen V.N. (2010)
    3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PubMed id 19339270)1, 4 Canova C....Brennan P. (2009)
    6. Identification of B94 (TNFAIP2) as a potential retinoic acid target gene in acute promyelocytic leukemia. (PubMed id 10766166)1, 9 Rusiniak M.E....Slack J.L. (2000)
    7. Proteomic analysis of the NOS2 interactome in human ai rway epithelial cells. (PubMed id 23438482)1 Foster M.W....Marshall H.E. (2013)
    8. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Genome-wide association study identifies 12 new susce ptibility loci for primary biliary cirrhosis. (PubMed id 21399635)1 Mells G.F....Anderson C.A. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7127 HGNC: 11895 AceView: TNFAIP2 Ensembl:ENSG00000185215 euGenes: HUgn7127
    ECgene: TNFAIP2 H-InvDB: TNFAIP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFAIP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFAIP2 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/tnfaip2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNFAIP2 gene:
    Search GeneIP for patents involving TNFAIP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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