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Aliases for TNFAIP2 Gene

Aliases for TNFAIP2 Gene

  • Tumor Necrosis Factor, Alpha-Induced Protein 2 2 3
  • Exocyst Complex Component 3-Like 3 2 3
  • Primary Response Gene B94 Protein 3 4
  • TNF Alpha-Induced Protein 2 3 4
  • Tumor Necrosis Factor Alpha-Induced Protein 2 3
  • EXOC3L3 3
  • B94 3

External Ids for TNFAIP2 Gene

Previous GeneCards Identifiers for TNFAIP2 Gene

  • GC14P100983
  • GC14P097408
  • GC14P101579
  • GC14P101582
  • GC14P102662
  • GC14P103592
  • GC14P083771

Summaries for TNFAIP2 Gene

Entrez Gene Summary for TNFAIP2 Gene

  • This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFAIP2 Gene

TNFAIP2 (Tumor Necrosis Factor, Alpha-Induced Protein 2) is a Protein Coding gene. Diseases associated with TNFAIP2 include primary mediastinal large b-cell lymphoma. An important paralog of this gene is EXOC3.

UniProtKB/Swiss-Prot for TNFAIP2 Gene

  • May play a role as a mediator of inflammation and angiogenesis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFAIP2 Gene

Genomics for TNFAIP2 Gene

Regulatory Elements for TNFAIP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNFAIP2 Gene

103,123,442 bp from pter
103,137,439 bp from pter
13,998 bases
Plus strand

Genomic View for TNFAIP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFAIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP2 Gene

Proteins for TNFAIP2 Gene

  • Protein details for TNFAIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor alpha-induced protein 2
    Protein Accession:
    Secondary Accessions:
    • Q86VI0

    Protein attributes for TNFAIP2 Gene

    654 amino acids
    Molecular mass:
    72661 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TNFAIP2 Gene

Proteomics data for TNFAIP2 Gene at MOPED

Post-translational modifications for TNFAIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for TNFAIP2 Gene

Domains for TNFAIP2 Gene

Protein Domains for TNFAIP2 Gene


Suggested Antigen Peptide Sequences for TNFAIP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q03169
  • Belongs to the SEC6 family.
genes like me logo Genes that share domains with TNFAIP2: view

No data available for Gene Families for TNFAIP2 Gene

Function for TNFAIP2 Gene

Molecular function for TNFAIP2 Gene

GENATLAS Biochemistry: tumor necrosis factor alpha,inducible primary response,2
UniProtKB/Swiss-Prot Function: May play a role as a mediator of inflammation and angiogenesis
UniProtKB/Swiss-Prot Induction: By TNF and other proinflammatory factors

Gene Ontology (GO) - Molecular Function for TNFAIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
genes like me logo Genes that share ontologies with TNFAIP2: view
genes like me logo Genes that share phenotypes with TNFAIP2: view

Animal Model Products

CRISPR Products

miRNA for TNFAIP2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TNFAIP2 Gene

Localization for TNFAIP2 Gene

Subcellular locations from

Jensen Localization Image for TNFAIP2 Gene COMPARTMENTS Subcellular localization image for TNFAIP2 gene
Compartment Confidence
extracellular 4
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TNFAIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IBA --
GO:0005615 extracellular space TAS 1374453
genes like me logo Genes that share ontologies with TNFAIP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TNFAIP2 Gene

Pathways for TNFAIP2 Gene

SuperPathways for TNFAIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TNFAIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006887 exocytosis IBA --
GO:0030154 cell differentiation IEA --
GO:0051601 exocyst localization IBA --
genes like me logo Genes that share ontologies with TNFAIP2: view

No data available for Pathways by source for TNFAIP2 Gene

Compounds for TNFAIP2 Gene

(3) ApexBio Compounds for TNFAIP2 Gene

Compound Action Cas Number
Lenalidomide (CC-5013) TNF-alfa secretion inhibitor with IC50 of 13 nM. [191732-72-6]
Necrostatin-1 Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-alfa-induced necroptosis with EC50 of 490 nM. [4311-88-0]
Pomalidomide (CC-4047) Pomalidomide, previously known as CC-4047 or actimid, is a potent immunomodulatory molecule that exhibits antineoplastic activity for the treatment of hematological malignancies, especially relapsed and refractory multiple myeloma (MM). [19171-19-8]

(2) Novoseek inferred chemical compound relationships for TNFAIP2 Gene

Compound -log(P) Hits PubMed IDs
cycloheximide 52.9 1
retinoic acid 46.1 6
genes like me logo Genes that share compounds with TNFAIP2: view

Transcripts for TNFAIP2 Gene

Unigene Clusters for TNFAIP2 Gene

Tumor necrosis factor, alpha-induced protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFAIP2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TNFAIP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP3: -

Relevant External Links for TNFAIP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFAIP2 Gene

mRNA expression in normal human tissues for TNFAIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFAIP2 Gene

This gene is overexpressed in Whole Blood (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNFAIP2 Gene

SOURCE GeneReport for Unigene cluster for TNFAIP2 Gene Hs.525607

genes like me logo Genes that share expressions with TNFAIP2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TNFAIP2 Gene

Orthologs for TNFAIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNFAIP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFAIP2 35
  • 93.47 (n)
  • 91.58 (a)
  • 99 (a)
(Bos Taurus)
Mammalia TNFAIP2 35
  • 84.15 (n)
  • 76.31 (a)
  • 73 (a)
(Canis familiaris)
Mammalia TNFAIP2 35
  • 85.68 (n)
  • 77.95 (a)
  • 74 (a)
(Mus musculus)
Mammalia Tnfaip2 35
  • 80.21 (n)
  • 72.4 (a)
Tnfaip2 16
Tnfaip2 36
  • 68 (a)
(Monodelphis domestica)
Mammalia TNFAIP2 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia TNFAIP2 36
  • 44 (a)
(Rattus norvegicus)
Mammalia Tnfaip2 35
  • 79.67 (n)
  • 72.91 (a)
(Gallus gallus)
Aves TNFAIP2 35
  • 51.2 (n)
  • 41.86 (a)
  • 36 (a)
(Anolis carolinensis)
Reptilia TNFAIP2 36
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfaip2 35
  • 45.29 (n)
  • 37.21 (a)
(Danio rerio)
Actinopterygii tnfaip2a 36
  • 23 (a)
tnfaip2b 35
  • 44.47 (n)
  • 32.04 (a)
tnfaip2b 36
  • 27 (a)
tnfaip2b 36
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec6 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea sec-6 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
Species with no ortholog for TNFAIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNFAIP2 Gene

Gene Tree for TNFAIP2 (if available)
Gene Tree for TNFAIP2 (if available)

Paralogs for TNFAIP2 Gene

Paralogs for TNFAIP2 Gene

genes like me logo Genes that share paralogs with TNFAIP2: view

Variants for TNFAIP2 Gene

Sequence variations from dbSNP and Humsavar for TNFAIP2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs8126 -- 103,137,232(+) GGGTC(C/T)GTCCC utr-variant-3-prime
rs710100 -- 103,135,941(-) TCTAA(C/T)GCTGG utr-variant-3-prime, reference, missense
rs749205 -- 103,131,188(+) GAGTC(A/G)CTCAG intron-variant
rs749206 -- 103,131,228(+) GGGAG(A/G)AGGAG intron-variant
rs944000 -- 103,133,168(-) GCATG(C/T)GTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFAIP2 Gene

Variant ID Type Subtype PubMed ID
nsv832882 CNV Loss 17160897
nsv902264 CNV Loss 21882294
nsv9168 CNV Loss 18304495
dgv1986n71 CNV Loss 21882294
nsv902267 CNV Loss 21882294
nsv902268 CNV Loss 21882294
dgv1987n71 CNV Loss 21882294
dgv1988n71 CNV Loss 21882294
nsv902275 CNV Loss 21882294
nsv902276 CNV Gain+Loss 21882294
dgv1989n71 CNV Loss 21882294
nsv902280 CNV Gain+Loss 21882294
nsv902282 CNV Gain+Loss 21882294
dgv1990n71 CNV Loss 21882294
nsv902284 CNV Gain 21882294
nsv902286 CNV Gain 21882294
nsv902287 CNV Gain 21882294
nsv902289 CNV Gain+Loss 21882294
esv2749162 CNV Deletion 23290073
esv2387988 CNV Deletion 18987734
nsv84629 CNV Loss 16902084
esv995383 CNV Deletion 20482838
esv1662663 CNV Deletion 17803354
nsv84480 CNV Loss 16902084
nsv902290 CNV Loss 21882294

Relevant External Links for TNFAIP2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFAIP2 Gene

Disorders for TNFAIP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TNFAIP2 Gene including...

Search for TNFAIP2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TNFAIP2 Gene

(2) Novoseek inferred disease relationships for TNFAIP2 Gene

Disease -log(P) Hits PubMed IDs
necrosis 38.9 3
tumors 8.63 2

Relevant External Links for TNFAIP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TNFAIP2: view

No data available for UniProtKB/Swiss-Prot for TNFAIP2 Gene

Publications for TNFAIP2 Gene

  1. Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro. (PMID: 1374453) Sarma V. … Dixit V.M. (J. Immunol. 1992) 2 3 4 23
  2. Identification of B94 (TNFAIP2) as a potential retinoic acid target gene in acute promyelocytic leukemia. (PMID: 10766166) Rusiniak M.E. … Slack J.L. (Cancer Res. 2000) 3 23
  3. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PMID: 19339270) Canova C. … Brennan P. (Cancer Res. 2009) 3 48
  4. SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance. (PMID: 20157331) Edvardsen H. … Kristensen V.N. (Pharmacogenomics J. 2010) 3 48
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for TNFAIP2 Gene

Sources for TNFAIP2 Gene

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