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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFAIP1 Gene

protein-coding   GIFtS: 55
GCID: GC17P026662

tumor necrosis factor, alpha-induced protein 1 (endothelial)


(Previous symbol: EDP1)
 Explore 16 diseases affiliated with
TNFAIP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TNFAIP1    

Aliases
for TNFAIP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Necrosis Factor, Alpha-Induced Protein 1 (Endothelial)1 2     HBACURD21
EDP11 2 3     MGC23171
B121 2     BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation Protein 22
B611 2     BACURD23
BTBD341 2     Protein B123
BTB/POZ Domain-Containing Protein TNFAIP12 3     Tumor Necrosis Factor, Alpha-Induced Protein 1, Endothelial3

External Ids:    HGNC: 118941   Entrez Gene: 71262   Ensembl: ENSG000001090797   OMIM: 1911615   UniProtKB: Q138293   

Export aliases for TNFAIP1 gene to outside databases

Previous GC identifers: GC17P026517 GC17P028562 GC17P026808 GC17P023686 GC17P022870


Summaries
for TNFAIP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TNFAIP1:
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in
umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is
developmentally regulated in a tissue-specific manner. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BACD2_HUMAN, Q13829
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in
regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of
RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its
interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity

Gene Wiki entry for TNFAIP1


Genomic Views
for TNFAIP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFAIP1 gene promoter:
         HSF1 (long)   Ik-3   Arnt   Max   PPAR-gamma1   Cart-1   HSF1short   Sox9   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFAIP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFAIP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFAIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22-q23   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q22-q23

TNFAIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFAIP1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P026662:  view genomic region     (about GC identifiers)

Start:
 26,662,548 bp from pter      End:
 26,674,035 bp from pter
Size:
 11,488 bases      Orientation:
 plus strand

Proteins
for TNFAIP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BACD2_HUMAN, Q13829 (See protein sequence)
Recommended Name: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2  
Size: 316 amino acids; 36204 Da
Subunit: Component of the BCR(BACURD2) E3 ubiquitin ligase complex, at least composed of CUL3, TNFAIP1/BACURD2 and
RBX1. Interacts with RHOA; with a preference for RhoA-GDP. Interacts with RHOB. Interacts with PCNA. Interacts with
CSNK2B
Subcellular location: Cytoplasm. Nucleus. Endosome. Note=Colocalizes with RHOB in endosomes
Secondary accessions: Q5TZQ1

Explore the universe of human proteins at neXtProt for TNFAIP1: NX_Q13829

Post-translational modifications:

  • Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13829

    • TNFAIP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066960.1  
    ENSEMBL proteins: 
     ENSP00000440749   ENSP00000464637   ENSP00000226225   ENSP00000464515   ENSP00000466301  

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    Novus Biologicals TNFAIP1 Lysate
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005768endosome IDA19637314
    GO:0031463Cul3-RING ubiquitin ligase complex IDA19782033


    TNFAIP1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TNFAIP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TNFAIP1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011333 BTB/POZ_fold
     IPR003131 T1-type_BTB
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q13829

    ProtoNet protein and cluster: Q13829

    1 Blocks protein family: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: BACD2_HUMAN, Q13829
    Similarity: Belongs to the BACURD family
    Similarity: Contains 1 BTB (POZ) domain


    Function
    for TNFAIP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BACD2_HUMAN, Q13829
    Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in
    regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of
    RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its
    interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity
    Induction: By TNF, IL1B/interleukin-1 beta and bacterial lipopolysaccharides (LPS)

         Genatlas biochemistry entry for TNFAIP1:
    tumor necrosis factor alpha,inducible primary response,1 (endothelial)

    miRNA
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    hsa-mir-373 (MIRT002521)

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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFAIP1 (see all 55):
    hsa-miR-194* hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-15a hsa-miR-29a hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmid: TNFAIP1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: TNFAIP1
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFAIP1 (see all 4)
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA19782033
    GO:0005515protein binding IPI19637314
    GO:0017049GTP-Rho binding IDA19637314
    GO:0019904protein domain specific binding IEA--


    TNFAIP1 for ontologies           About GeneDecksing


    Animal Models:
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tnfaip1):
     behavior/neurological  growth/size  homeostasis/metabolism  limbs/digits/tail  other 
     skeleton 

    TNFAIP1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TNFAIP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: BACD2_HUMAN, Q13829
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFAIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/20 Interacting proteins for TNFAIP1 (Q138291, 2, 3 ENSP000002262254) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOBP627451, 3, ENSP000002722334EBI-2505861,EBI-602647 I2D: score=2 STRING: ENSP00000272233
    EPHA2P293173, ENSP000003512094I2D: score=2 STRING: ENSP00000351209
    KCTD13Q8WZ193, ENSP000003112024I2D: score=2 STRING: ENSP00000311202
    SVILO954253, ENSP000003481284I2D: score=1 STRING: ENSP00000348128
    KLHL12ENSP000003562304STRING: ENSP00000356230
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication ISS--
    GO:0006915apoptotic process TAS19637314
    GO:0006955immune response IEP1370465
    GO:0009790embryo development ISS--
    GO:0016477cell migration IMP19782033


    TNFAIP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TNFAIP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFAIP1
    Search CenterWatch for drugs/clinical trials and news about TNFAIP1 / BACD2 

    Transcripts
    for TNFAIP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TNFAIP1 gene: 
    NM_021137.4  

    Unigene Cluster for TNFAIP1:

    Tumor necrosis factor, alpha-induced protein 1 (endothelial)
    Hs.76090  [show with all ESTs]
    Unigene Representative Sequence: NM_021137
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000544907 ENST00000578158 ENST00000226225(uc002hax.2 uc002hay.3 uc010waf.2)
    ENST00000583213 ENST00000582302 ENST00000577535

    miRNA
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFAIP1 (see all 55):
    hsa-miR-194* hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-15a hsa-miR-29a hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmid: TNFAIP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFAIP1 (see all 7)
    OriGene shRNA RFP: TNFAIP1
    OriGene siRNA: TNFAIP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFAIP1
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFAIP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFAIP1

    Additional cDNA sequence: 

    AK300584.1 AK312387.1 BC001643.2 BC001949.1 BC003694.2 BT020121.1 CR456819.1 M80783.1 

    18 DOTS entries:

    DT.100821594  DT.100821597  DT.119349  DT.100821587  DT.100821592  DT.102835276  DT.120958087  DT.120958010 
    DT.91674224  DT.100821598  DT.120958020  DT.120958055  DT.120958062  DT.75156283  DT.95254416  DT.97860767 
    DT.91643928  DT.95124733 

    24/495 AceView cDNA sequences (see all 495):

    AI056074 AW732912 AA369207 BQ448002 AI566915 AI962948 CR621837 BQ894342 
    BQ881906 BQ953832 AI755179 BP356497 AU107336 BG491303 AL546735 AI082485 
    BU838303 AI079553 AI658780 BE270105 W42949 CA432099 BM811439 AA456314 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:              -                                                         
    SP2:              -     -     -     -                                       
    SP3:              -     -     -                                             
    SP4:              -           -     -                                       
    SP5:                                                                        


    ECgene alternative splicing isoforms for TNFAIP1

    Expression
    for TNFAIP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFAIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATCTTAGCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TNFAIP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFAIP1

    SOURCE GeneReport for Unigene cluster: Hs.76090
        SABiosciences Expression via Pathway-Focused PCR Array including TNFAIP1: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for TNFAIP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TNFAIP1 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TNFAIP11 tumor necrosis factor, alpha-induced protein 1 (endothelial) 77.42(n)
    92.26(a)    		   417672  NM_001030726.1  NP_001025897.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TNFAIP16
    		 --
    		 81(a)
    		 1 ↔ 1
    		 GL344488.1(802-16065)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.241892 Xenopus laevis transcribed sequence with moderate similarity more 76.35(n)    CA983258.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi06b022 wufi06b02 76.11(n)   327399  BC044362.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG104653   -- 64(a)   41F3   --
    worm
    (Caenorhabditis elegans)    		 Secernentea ZC239.136
    ZC239.176
    (see all 28)    		 Protein ZC239.17
    (see all 28)    		 33(a)
    30(a)
    (see all 28)    		 many ↔ many
    many ↔ many
    (see all 28)    		 II(3222409-3222830)
    II(3225465-3225971)


    ENSEMBL Gene Tree for TNFAIP1 (if available)
    TreeFam Gene Tree for TNFAIP1 (if available) 

    Paralogs
    for TNFAIP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFAIP1 gene
    KCTD132  KCTD102  
    4 SIMAP similar genes for TNFAIP1 using alignment to 5 protein entries:     BACD2_HUMAN (see all proteins):
    KCTD10    KCTD13    KCTD21    KCTD6

    TNFAIP1 for paralogs           About GeneDecksing



    Genomic Variants
    for TNFAIP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/238 NCBI SNPs in TNFAIP1 are shown (see all 238)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs30937031,2
    		C,F,H,--22881579(+) GGGACA/GGGGGA 1 -- ds5001 ese38Minor allele frequency- G:0.02NS EA NA WA 630
    rs801739601,2
    		--22881700(+) CCTCAT/CTGAGG 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs30937051,2
    		C,F,H,--22881761(+) TTATGA/GCTTTC 1 -- ds50017Minor allele frequency- G:0.01NS EA WA 628
    rs30937061,2
    		C,F,H,--22881792(+) CAGCCT/CGAGAC 1 -- ds5001 ese36Minor allele frequency- C:0.01NS NA 498
    rs30937071,2
    		C,F--22882256(+) TAACAACACA/- 
                GGCCA     		1 -- ut312Minor allele frequency- -:0.02NS 90
    rs30937081,2
    		C,F,H,--22882288(+) ATTTGG/ATATGT 1 -- ut3114Minor allele frequency- A:0.07NS EA NA WA 1396
    rs30937091,2
    		F,H--22882290(+) TTGGTA/GTGTGA 1 -- ut316Minor allele frequency- G:0.01NS EA 496
    rs30937101,2
    		C,F,H,--22882491(+) GCTGAG/ATTCCT 1 -- ut3112Minor allele frequency- A:0.04NS EA NA WA 1170
    rs30937111,2
    		F--22882532(+) CTAGCCAGGTCG 
     TAAGC    /-    GCGAC     		1 -- ut312Minor allele frequency- -:0.12NS 84
    rs2012830451,2
    		C--22882889(-) GAGGAA/GGGAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TNFAIP1 (26662548 - 26674035 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TNFAIP1: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for TNFAIP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TNFAIP1 for disorders           About GeneDecksing

    OMIM gene information: 191161    OMIM disorders: --

    16 diseases for TNFAIP1:    About MalaCards
    anorexia nervosa    systemic lupus erythematosus    lupus erythematosus    rheumatoid arthritis
    hepatitis b    cerebral malaria    sarcoidosis    alzheimer's disease
    cerebritis    arthritis    nephropathy    breast cancer
    asthma    hepatitis    obesity    malaria

    Genetic Association Database (GAD): TNFAIP1
    Human Genome Epidemiology (HuGE) Navigator: TNFAIP1 (9 documents)

    Export disorders for TNFAIP1 gene to outside databases

    Publications
    for TNFAIP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFAIP1 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with TNFAIP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. CK2 phosphorylates TNFAIP1 to affect its subcellular localization and interaction with PCNA. (PubMed id 19851886)1, 2 Yang L.... Zhang J. (2009)
    2. Cullin mediates degradation of RhoA through evolution arily conserved BTB adaptors to control actin cytoskeleton structure and cell m ovement. (PubMed id 19782033)1, 2 Chen Y....Shao F. (2009)
    3. RhoB induces apoptosis via direct interaction with TN FAIP1 in HeLa cells. (PubMed id 19637314)1, 2 Kim D.M....Seo Y.S. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Polymorphism of the cytokine genes and IgA nephropathy. (PubMed id 11849463)1, 4 Syrjanen J....Pasternack A. (2002)
    6. TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis. (PubMed id 12039524)1, 4 Pandey J.P. and Frederick M. (2002)
    7. Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with systemic lupus erythematosus (SLE). (PubMed id 11704801)1, 4 Zuniga J....Granados J. (2001)
    8. Strong association of a tumor necrosis factor-alpha promoter allele with cerebral malaria in Myanmar. (PubMed id 11929592)1, 4 Ubalee R....Hirayama K. (2001)
    9. Influence of HLA-DRB1 and TNF microsatellite polymorphisms on the expression of extraarticular manifestations in rheumatoid arthritis patients from northwest Spain. (PubMed id 11791643)1, 4 Mattey D.L....Ollier W.E. (2001)
    10. Analysis of tumor necrosis factor-alpha gene promoter polymorphisms in anorexia nervosa. (PubMed id 11702059)1, 4 Ando T....Komaki G. (2001)

    External Searches for TNFAIP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TNFAIP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7126 HGNC: 11894 AceView: TNFAIP1 Ensembl:ENSG00000109079 euGenes: HUgn7126
    ECgene: TNFAIP1 H-InvDB: TNFAIP1

    Other Databases showing TNFAIP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TNFAIP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFAIP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFAIP1 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/tnfaip1/

    Intellectual Property
    for TNFAIP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TNFAIP1 gene:
    Search GeneIP for patents involving TNFAIP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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