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TNFAIP1 Gene

protein-coding   GIFtS: 58
GCID: GC17P026662

Tumor Necrosis Factor, Alpha-Induced Protein 1 (Endothelial)


(Previous symbol: EDP1)
  See TNFAIP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor, Alpha-Induced Protein 1 (Endothelial)1 2     BTBD342
EDP11 2 3     BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation
Protein 22
BTB/POZ Domain-Containing Protein TNFAIP12 3     BACURD23
hBACURD22 3     Protein B123
B122     Tumor Necrosis Factor, Alpha-Induced Protein 1, Endothelial3
B612     

External Ids:    HGNC: 118941   Entrez Gene: 71262   Ensembl: ENSG000001090797   OMIM: 1911615   UniProtKB: Q138293   

Export aliases for TNFAIP1 gene to outside databases

Previous GC identifers: GC17P026517 GC17P028562 GC17P026808 GC17P023686 GC17P022870


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFAIP1 Gene:
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in
umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is
developmentally regulated in a tissue-specific manner. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFAIP1 Gene:
TNFAIP1 (tumor necrosis factor, alpha-induced protein 1 (endothelial)) is a protein-coding gene. Diseases associated with TNFAIP1 include malaria. GO annotations related to this gene include GTP-Rho binding and ubiquitin-protein ligase activity. An important paralog of this gene is KCTD13.

UniProtKB/Swiss-Prot: BACD2_HUMAN, Q13829
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in
regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of
RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.
Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity

Gene Wiki entry for TNFAIP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFAIP1 gene promoter:
         HSF1 (long)   Ik-3   Arnt   Max   PPAR-gamma1   Cart-1   HSF1short   Sox9   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFAIP1 promoter sequence
   Search Chromatin IP Primers for TNFAIP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFAIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22-q23   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q22-q23

TNFAIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFAIP1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P026662:  view genomic region     (about GC identifiers)

Start:
26,662,548 bp from pter      End:
26,674,035 bp from pter
Size:
11,488 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BACD2_HUMAN, Q13829 (See protein sequence)
Recommended Name: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2  
Size: 316 amino acids; 36204 Da
Subunit: Component of the BCR(BACURD2) E3 ubiquitin ligase complex, at least composed of CUL3, TNFAIP1/BACURD2 and
RBX1. Interacts with RHOA; with a preference for RhoA-GDP. Interacts with RHOB. Interacts with PCNA. Interacts
with CSNK2B
Secondary accessions: Q5TZQ1

Explore the universe of human proteins at neXtProt for TNFAIP1: NX_Q13829

Explore proteomics data for TNFAIP1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA1
  • Ubiquitination2 at Lys14, Lys21
  • Modification sites at PhosphoSitePlus

  • See TNFAIP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066960.1  
    ENSEMBL proteins: 
     ENSP00000440749   ENSP00000464637   ENSP00000226225   ENSP00000464515   ENSP00000466301  

    TNFAIP1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing

    3 InterPro protein domains:
     IPR011333 BTB/POZ_fold
     IPR003131 T1-type_BTB
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q13829

    ProtoNet protein and cluster: Q13829

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: BACD2_HUMAN, Q13829
    Similarity: Belongs to the BACURD family
    Similarity: Contains 1 BTB (POZ) domain


    Find genes that share domains with TNFAIP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BACD2_HUMAN, Q13829
    Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in
    regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of
    RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.
    Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity
    Induction: By TNF, IL1B/interleukin-1 beta and bacterial lipopolysaccharides (LPS)

         Genatlas biochemistry entry for TNFAIP1:
    tumor necrosis factor alpha,inducible primary response,1 (endothelial)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA19782033
    GO:0005515protein binding IPI19637314
    GO:0017049GTP-Rho binding IDA19637314
    GO:0019904protein domain specific binding IEA--
         
    Find genes that share ontologies with TNFAIP1           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tnfaip1):
     behavior/neurological  growth/size/body  homeostasis/metabolism  limbs/digits/tail  other 
     skeleton 

    Find genes that share phenotypes with TNFAIP1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFAIP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFAIP1
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    miRNA
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    miRTarBase miRNAs that target TNFAIP1:
    hsa-mir-17-5p (MIRT051004), hsa-let-7e-5p (MIRT051605), hsa-mir-484 (MIRT042325), hsa-mir-373-3p (MIRT002521), hsa-mir-1296-5p (MIRT036098)

    Block miRNA regulation of human, mouse, rat TNFAIP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNFAIP1 (see all 55):
    hsa-miR-194* hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-15a hsa-miR-29a hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTNFAIP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TNFAIP1

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    GenScript: all cDNA clones in your preferred vector: TNFAIP1 (NM_021137)
    Sino Biological Human cDNA Clone for TNFAIP1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BACD2_HUMAN, Q13829: Cytoplasm. Nucleus. Endosome. Note=Colocalizes with RHOB in endosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    nucleus5
    cytosol3
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA19637314
    GO:0005768endosome IDA19637314
    GO:0031463Cul3-RING ubiquitin ligase complex IDA19782033

    Find genes that share ontologies with TNFAIP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: BACD2_HUMAN, Q13829
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including TNFAIP1: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFAIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for TNFAIP1 (Q138291, 2, 3 ENSP000002262254) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOBP627451, 3, ENSP000002722334EBI-2505861,EBI-602647 I2D: score=2 STRING: ENSP00000272233
    EPHA2P293173, ENSP000003512094I2D: score=2 STRING: ENSP00000351209
    KCTD13Q8WZ193, ENSP000003112024I2D: score=2 STRING: ENSP00000311202
    SVILO954253, ENSP000003481284I2D: score=1 STRING: ENSP00000348128
    KLHL12ENSP000003562304STRING: ENSP00000356230
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication ISS--
    GO:0006915apoptotic process TAS19637314
    GO:0006955immune response IEP1370465
    GO:0009790embryo development ISS--
    GO:0016477cell migration IMP19782033

    Find genes that share ontologies with TNFAIP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFAIP1 (BACD2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNFAIP1 gene: 
    NM_021137.4  

    Unigene Cluster for TNFAIP1:

    Tumor necrosis factor, alpha-induced protein 1 (endothelial)
    Hs.76090  [show with all ESTs]
    Unigene Representative Sequence: NM_021137
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000544907 ENST00000578158 ENST00000226225(uc002hax.2 uc002hay.3 uc010waf.2)
    ENST00000583213 ENST00000582302 ENST00000577535
    miRNA
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    Block miRNA regulation of human, mouse, rat TNFAIP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNFAIP1 (see all 55):
    hsa-miR-194* hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-15a hsa-miR-29a hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTNFAIP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TNFAIP1
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      QuantiTect SYBR Green Assays in human, mouse, rat TNFAIP1
      QuantiFast Probe-based Assays in human, mouse, rat TNFAIP1

    Additional mRNA sequence: 

    AK300584.1 AK312387.1 BC001643.2 BC001949.1 BC003694.2 BT020121.1 CR456819.1 M80783.1 

    17 DOTS entries:

    DT.100821594  DT.100821597  DT.119349  DT.100821592  DT.102835276  DT.100821587  DT.120958087  DT.120958010 
    DT.91674224  DT.100821598  DT.120958055  DT.120958062  DT.75156283  DT.95254416  DT.97860767  DT.91643928 
    DT.95124733 

    Selected AceView cDNA sequences (see all 495):

    AI056074 AA219487 AI313367 AW591484 AI189096 AI934749 AA643645 AI755179 
    BI821240 CR615941 AW731859 AA587041 AA349339 AA385522 BU543580 BU543059 
    AU100122 F06692 AI080753 AA632044 AA932819 BU680863 BM762489 BP355332 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:              -                                                         
    SP2:              -     -     -     -                                       
    SP3:              -     -     -                                             
    SP4:              -           -     -                                       
    SP5:                                                                        


    ECgene alternative splicing isoforms for TNFAIP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFAIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTTAGCTT
    TNFAIP1 Expression
    About this image

    TNFAIP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFAIP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.76090
        Pathway & Disease-focused RT2 Profiler PCR Array including TNFAIP1: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TNFAIP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFAIP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TNFAIP1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfaip11 , 5 tumor necrosis factor, alpha-induced protein 1 (endothelial)1, 5 91.35(n)1
    97.15(a)1
      11 (46.74 cM)5
    219271  NM_001159392.11  NP_001152864.11 
     785228505 
    chicken
    (Gallus gallus)
    Aves TNFAIP11 tumor necrosis factor, alpha-induced protein 1 (endothelial) 77.42(n)
    92.26(a)
      417672  NM_001030726.1  NP_001025897.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNFAIP16
    tumor necrosis factor, alpha-induced protein 1 (en...
    82(a)
    1 ↔ 1
    GL344488.1(802-16059)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.241892 Xenopus laevis transcribed sequence with moderate similarity more 76.35(n)    CA983258.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi06b022 wufi06b02 76.11(n)   327399  BC044362.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG104653   -- 64(a)   41F3   --
    worm
    (Caenorhabditis elegans)
    Secernentea ZC239.136
    ZC239.176
    (see all 29)
    Protein ZC239.17 (ZC239.17) mRNA, complete cds
    (see all 29)
    35(a)
    35(a)
    (see all 29)
    many ↔ many
    many ↔ many
    (see all 29)
    II(3222406-3222827) WBGene00022571
    II(3225462-3225968) WBGene00022575


    ENSEMBL Gene Tree for TNFAIP1 (if available)
    TreeFam Gene Tree for TNFAIP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNFAIP1 gene
    KCTD132  KCTD102  
    5 SIMAP similar genes for TNFAIP1 using alignment to 5 protein entries:     BACD2_HUMAN (see all proteins):
    KCTD10    KCTD13    KCTD21    KCTD6    SHKBP1

    Find genes that share paralogs with TNFAIP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFAIP1 (see all 208)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1479152071,2
    C--26664633(+) AAGCAA/GTCCAC 1 -- int10--------
    rs1881183531,2
    --26664653(+) CCTCCC/TAAAGT 1 -- int10--------
    rs30936801,2
    C,F,A,H--26664806(+) tccctC/Ttgtct 1 -- int127Minor allele frequency- T:0.26NS EA NA WA CSA 3377
    rs1144904291,2
    F--26664967(+) TTTCTA/GTATGT 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1143985631,2
    C,F--26664987(+) TGAGTA/CCCCAA 1 -- int11Minor allele frequency- C:0.04WA 118
    rs1810879851,2
    C--26665442(+) TGAAAA/GATGGT 1 -- int10--------
    rs724187021,2
    C--26665500(+) GTCAG-/GAAGC 
     CCCAGCC
    GAAGC
    1 -- int10--------
    rs10073981,2
    C,F,O,A,H--26665648(-) AGCAGC/TCTGTG 1 -- int148Minor allele frequency- T:0.23NA EA MN NS WA CSA 4252
    rs1862725661,2
    --26665649(+) ACAGAC/GTGCTC 1 -- int10--------
    rs30937201,2
    C,F,O,H--26665768(+) GGAACC/ATTGAC 1 -- int134Minor allele frequency- A:0.06NS EA NA 4158

    HapMap Linkage Disequilibrium report for TNFAIP1 (26662548 - 26674035 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TNFAIP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2017CNV Insertion18451855
    nsv519388CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFAIP1
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFAIP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 191161    OMIM disorders: --

    1 disease for TNFAIP1:    
    About MalaCards
    malaria


    Find genes that share disorders with TNFAIP1           About GenesLikeMe

    Genetic Association Database (GAD): TNFAIP1
    Human Genome Epidemiology (HuGE) Navigator: TNFAIP1 (9 documents)

    Export disorders for TNFAIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFAIP1 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with TNFAIP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CK2 phosphorylates TNFAIP1 to affect its subcellular localization and interaction with PCNA. (PubMed id 19851886)1, 2 Yang L.... Zhang J. (Mol. Biol. Rep. 2010)
    2. Joint effect of obesity and TNFA variability on asthma: two international cohort studies. (PubMed id 19196817)1, 4 Castro-Giner F....Probst-Hensch N.M. (Eur. Respir. J. 2009)
    3. Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. (PubMed id 19782033)1, 2 Chen Y.... Shao F. (Mol. Cell 2009)
    4. RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells. (PubMed id 19637314)1, 2 Kim D.M.... Seo Y.S. (Int. J. Cancer 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Polymorphism of the cytokine genes and IgA nephropathy. (PubMed id 11849463)1, 4 SyrjAonen J....Pasternack A. (Kidney Int. 2002)
    7. TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis. (PubMed id 12039524)1, 4 Pandey J.P. and Frederick M. (Hum. Immunol. 2002)
    8. Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with systemic lupus erythematosus (SLE). (PubMed id 11704801)1, 4 ZA_A+iga J....Granados J. (Genes Immun. 2001)
    9. Strong association of a tumor necrosis factor-alpha promoter allele with cerebral malaria in Myanmar. (PubMed id 11929592)1, 4 Ubalee R....Hirayama K. (Tissue Antigens 2001)
    10. Influence of HLA-DRB1 and TNF microsatellite polymorphisms on the expression of extraarticular manifestations in rheumatoid arthritis patients from northwest Spain. (PubMed id 11791643)1, 4 Mattey D.L....Ollier W.E. (Clin. Exp. Rheumatol. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7126 HGNC: 11894 AceView: TNFAIP1 Ensembl:ENSG00000109079 euGenes: HUgn7126
    ECgene: TNFAIP1 H-InvDB: TNFAIP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TNFAIP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFAIP1 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/tnfaip1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFAIP1 gene:
    Search GeneIP for patents involving TNFAIP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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