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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

TNF Gene

protein-coding   GIFtS: 72
GCID: GC06P031543

Tumor Necrosis Factor

(Previous names: tumor necrosis factor (TNF superfamily, member 2))
(Previous symbol: TNFA)
Microbiology & Infectious Diseases Congress
  See related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Tumor Necrosis Factor1 2     Tumor Necrosis Factor (TNF Superfamily, Member 2)1
TNFA1 2 3 5     DIF2
Tumor Necrosis Factor Ligand Superfamily Member 22 3     APC1 Protein2
TNF-a2 3     cachectin2
TNF-alpha2 3     TNF, Macrophage-Derived2
TNFSF22 3     TNF, Monocyte-Derived2
Member 21     Tumor Necrosis Factor-Alpha2
TNF Superfamily1     Cachectin3

External Ids:    HGNC: 118921   Entrez Gene: 71242   Ensembl: ENSG000002328107   OMIM: 1911605   UniProtKB: P013753   

Export aliases for TNF gene to outside databases

Previous GC identifers: GC06P031606 GC06P031597 GC06P031314 GC06P031647 GC06P031652 GC06P031330

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNF Gene:
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF)
superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its
receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of
biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.
This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance,
and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TNF Gene: 
TNF (tumor necrosis factor) is a protein-coding gene. Diseases associated with TNF include aphthous stomatitis, and magic syndrome, and among its related super-pathways are HIV-1 Nef- Negative effector of Fas and TNF-alpha and Apoptosis and survival FAS signaling cascades. GO annotations related to this gene include transcription regulatory region DNA binding and identical protein binding. An important paralog of this gene is FASLG.

UniProtKB/Swiss-Prot: TNFA_HUMAN, P01375
Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can
induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by
stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions
it can stimulate cell proliferation and induce cell differentiation
Function: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells

summary for TNF Gene:
NF-kappaB (nuclear factor-kappa B) is a rapidly acting primary transcription factor found in all cell types.
It is involved in cellular responses to stimuli such as cytokines and stress and plays a key role in
regulating the immune response to infection. In unstimulated cells NF-kappaB dimers are sequestered
inactively in the cytoplasm by a protein complex called inhibitor of kappa B (IkappaB). IkappaB inactivates
NF-kappaB by masking the nuclear localization signals (NLS). Activation of NF-kappaB occurs via degradation
of IkappaB, a process that is initiated by its phosphorylation by IkappaB kinase (IKK). Phosphorylated
IkappaB becomes dissociated from NF-kappaB, unmasking the NLS. Phosphorylation also results in IkappaB
ubiquitination and targeting to the proteasome. NF-kappaB can now enter the nucleus and regulate gene
expression. NF-kappaB turns on expression of IkappaB forming a negative feedback loop.

Gene Wiki entry for TNF (Tumor necrosis factor-alpha) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNF gene promoter:
         c-Fos   p53   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TNF promoter sequence
   Search SABiosciences Chromatin IP Primers for TNF

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

TNF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNF gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031543:  view genomic region     (about GC identifiers)

31,543,344 bp from pter      End:
31,546,113 bp from pter
2,770 bases      Orientation:
plus strand

6/7 alternative locations (see all 7):
Chr6+,NT_167245 2,828,891-2,831,653      Chr6+,NT_167247 2,923,056-2,925,818      Chr6+,NT_113891.2 3,052,966-3,055,728     
Chr6+,NT_167249 2,874,151-2,876,913      Chr6+,NT_167246 2,886,234-2,888,996      Chr6+,NT_167248 2,836,988-2,839,752     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNFA_HUMAN, P01375 (See protein sequence)
Recommended Name: Tumor necrosis factor precursor  
Size: 233 amino acids; 25644 Da
Subunit: Homotrimer. Interacts with SPPL2B
Subcellular location: Cell membrane; Single-pass type II membrane protein
Subcellular location: Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein
Subcellular location: Tumor necrosis factor, soluble form: Secreted
Subcellular location: C-domain 1: Secreted
Subcellular location: C-domain 2: Secreted
Sequence caution: Sequence=AAF71992.1; Type=Frameshift; Positions=91, 157; Sequence=CAA75070.1; Type=Erroneous
gene model prediction;
6/13 PDB 3D structures from and Proteopedia for TNF (see all 13):
1A8M (3D)        1TNF (3D)        2AZ5 (3D)        2E7A (3D)        2TUN (3D)        2ZJC (3D)    
Secondary accessions: O43647 Q9P1Q2 Q9UIV3

Explore the universe of human proteins at neXtProt for TNF: NX_P01375

Explore proteomics data for TNF at MOPED 

Post-translational modifications:

  • UniProtKB: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further
    proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF
    intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the
    extracellular space
  • UniProtKB: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the
    membrane form occurs by binding to soluble TNFRSF1A/TNFR1
  • UniProtKB: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01375

  • TNF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNF Protein Expression
    REFSEQ proteins: NP_000585.2  
    ENSEMBL proteins: 
    Reactome Protein details: P01375
    Human Recombinant Protein Products for TNF: 
    EMD Millipore Purified and/or Recombinant TNF Protein
    R&D Systems Recombinant & Natural Proteins for TNF (TNF-alpha/TNFSF1A)
    Enzo Life Sciences proteins for TNF
    OriGene Purified Proteins for TNF
    OriGene Protein Over-expression Lysate for TNF
    OriGene MassSpec for TNF 
    OriGene Custom Protein Services for TNF
    GenScript Purified and Recombinant Proteins for TNF
    Novus Biologicals TNF Proteins
    Novus Biologicals TNF Lysate
    Sino Biological Recombinant Protein for TNF
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TNF
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001891phagocytic cup ISS--
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA10443688
    GO:0005622intracellular ----
    GO:0005886plasma membrane TAS--

    TNF for ontologies           About GeneDecksing

    TNF Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TNF
    R&D Systems Antibodies for TNF (TNF-alpha/TNFSF1A)
    OriGene Antibodies for TNF
    OriGene Custom Antibody Services for TNF
    GenScript Superior Antibodies for TNF
    Novus Biologicals TNF Antibodies
    Abcam antibodies for TNF
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for TNF
    LSBio Antibodies in human, mouse, rat for TNF 

    Assay Products for TNF: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TNF
    R&D Systems Flow Cytometry Kits for TNF (TNF-alpha/TNFSF1A)         (see all)
    GenScript Custom Assay Services for TNF
    Enzo Life Sciences assays for TNF
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TNFSF: Tumor necrosis factor (ligand) superfamily

    5 InterPro protein domains:
     IPR002959 TNF_alpha
     IPR006052 TNF
     IPR006053 TNF_a/b/c
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR021184 TNF_CS

    Graphical View of Domain Structure for InterPro Entry P01375

    ProtoNet protein and cluster: P01375

    3 Blocks protein domains:
    IPB002959 Tumour necrosis factor alpha (cachectin) signature
    IPB006052 Tumor Necrosis Factor
    IPB006053 Tumour necrosis factor family signature

    UniProtKB/Swiss-Prot: TNFA_HUMAN, P01375
    Similarity: Belongs to the tumor necrosis factor family

    TNF for domains           About GeneDecksing

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNFA_HUMAN, P01375
    Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can
    induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by
    stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions
    it can stimulate cell proliferation and induce cell differentiation
    Function: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells

         Genatlas biochemistry entry for TNF:
    tumor necrosis factor,alpha (cachectin),potent proinflammatory cytokine,involved in inflammatory and immune
    responses,stimulating the sphingomyelinase (SMPD1),enhancing insulin resistance in peripheral tissues of cancer
    patients,susceptibility factor for narcolepsy and myasthenia gravis and cardiac sarcoidosis,with a common
    polymorphism in the promoter region (C->A) associated with reduced circulating levels of TNF,mediating neuronal
    death in injured brain (by inducing resistance to the protective effect of IGF1)

    During embryonic development, TNF as signaling molecule
    affects the following cells: Fetal Hepatocytes in Liver Lobule

    TNF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Mature dendritic-like cells from Blood, Dendritic-like cells from Blood

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI12777399
    GO:0005125cytokine activity IDA10748004
    GO:0005164tumor necrosis factor receptor binding IDA14512626
    GO:0005515protein binding IPI11878931
    GO:0042802identical protein binding IDA14512626
    TNF for ontologies           About GeneDecksing

         1 GenomeRNAi human phenotype for TNF:
     Increased cell death in breast 

         15/24 MGI mutant phenotypes (inferred from 19 alleles(MGI details for Tnf) (see all 24):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    TNF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TNF: Ltb/TnfLtb/tm1.1Dvk Lta/TnfLta/tm1Eug Tnftm1Jods Lta/TnfLta/tm1Fda Tnftm1Sek Tnftm1Gkl
                                                         Tnftm3Gkl Ltb/Tnf/LtaLtb/Tnf/tm1Dvk Tnftm2.1Gkl Tnftm1Ljo Tnftm1.2Sned Lta/TnfLta/tm1Jods Tnftm2Gkl

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNF 

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNF
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate TNF (see all 29):
    hsa-miR-549 hsa-miR-875-3p hsa-miR-181c hsa-miR-3141 hsa-miR-4263 hsa-miR-331-3p hsa-miR-301a hsa-miR-181a-2*
    SwitchGear 3'UTR luciferase reporter plasmidTNF 3' UTR sequence
    Inhib. RNA
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TNF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNF

    Gene Editing
    DNA2.0 Custom Protein Engineering Service for TNF
    Sirion Biotech Customized adenovirus for overexpression of TNF

    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TNF (see all 7)
    OriGene ORF clones in mouse, rat for TNF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNF (NM_001192)
    Sino Biological Human cDNA Clone for TNF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNF
    Sirion Biotech Customized lentivirus for stable overexpression of TNF 
                         Customized lentivirus expression plasmids for stable overexpression of TNF 

    Cell Line
    GenScript Custom overexpressing Cell Line Services for TNF
    Search LifeMap BioReagents cell lines for TNF
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNF

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNF About   (see all 96)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TNFR1 Pathway0.56
    Apoptotic Pathways Triggered By HIV10.42
    TNF Signaling0.55
    Apoptosis through Death Receptors0.42
    Apoptosis and survival TNFR1 signaling pathway0.52
    TWEAK Signaling Pathway0.31
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    2Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    Caspase cascade in apoptosis0.42
    FAS pathway and Stress induction of HSP regulation0.44
    3Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    Immune response IL-9 signaling pathway0.42
    Adipocytokines & Insulin Signaling0.34
    IL-9 Pathway0.36
    4PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    IL-6 Pathway0.61
    MIF Regulation of Innate Immune Cells0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    5Allograft rejection
    Allograft rejection0.69
    Type I diabetes mellitus0.69
    THC Differentiation Pathway0.37
    Graft-versus-host disease0.65
    Antigen processing and presentation0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/14 EMD Millipore Pathways for TNF (see all 14)
        Immune response CD16 signaling in NK cells
    Immune response IL-9 signaling pathway
    Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response
    Immune response IL-1 signaling pathway

    5/8 R&D Systems Pathways for TNF (see all 8)
        NOD-like Receptor Signaling Pathways
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    Adipocytokines & Insulin Signaling
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways

    5/50 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNF (see all 50)
        Caspase Cascade
    THC Differentiation Pathway
    14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    1 Cell Signaling Technology (CST) Pathway for TNF
        NF-kappaB Signaling

    5/15 GeneGo (Thomson Reuters) Pathways for TNF (see all 15)
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Immune response MIF-mediated glucocorticoid regulation
    Apoptosis and survival Caspase cascade
    Immune response MIF in innate immunity response
    Immune response IL-9 signaling pathway

    5/35 BioSystems Pathways for TNF (see all 35)
        MAPK signaling pathway
    EBV LMP1 signaling
    Cytokines and Inflammatory Response
    MicroRNAs in cardiomyocyte hypertrophy

    3 Sino Biological Pathways for TNF 
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    4        Reactome Pathways for TNF
        Death Receptor Signalling
    TNF signaling
    Extrinsic Pathway for Apoptosis

    5/45         Kegg Pathways  (Kegg details for TNF) (see all 45):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    NF-kappa B signaling pathway
    mTOR signaling pathway

    TNF for pathways           About GeneDecksing


        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/113 Interacting proteins for TNF (P013751, 2, 3 ENSP000003986984) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K92, 3MINT-8410390 I2D: score=1 
    RBCK1Q9BYM82, 3MINT-8410390 I2D: score=1 
    RNF31Q96EP02, 3MINT-8410390 I2D: score=1 
    TNFAIP3P215802, 3MINT-8410390 I2D: score=1 
    ENSG00000096150P622693I2D: score=1 
    About this table

    Gene Ontology (GO): 5/122 biological process terms (GO ID links to tree view) (see all 122):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IDA16280327
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15345745
    GO:0000165MAPK cascade IMP--
    GO:0000185activation of MAPKKK activity IDA15310755
    GO:0000187activation of MAPK activity IDA10748004

    TNF for ontologies           About GeneDecksing

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNF for compounds           About GeneDecksing

    EMD Millipore small molecules for TNF:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for TNF

    Compounds for TNF available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SC 514IKKbeta inhibitor; attenuates NF-kappaB-induced gene expression[354812-17-2]
    Ro 106-9920Inhibitor of NF-kappaB activation[62645-28-7]
    IMD 0354Inhibitor of IKKbeta[978-62-1]
    CelastrolInhibits TNF-alpha-induced NF-kappaB activation[34157-83-0]
    Bay 11-7085Irreversible inhibitor of TNF-alpha-induced IkappaBalpha phosphorylation[196309-76-9]

    4 HMDB Compounds for TNF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Butyric acid1-Butyrate (see all 25)107-92-616142751
    AtorvastatinAtorvastatin acid (see all 4)134523-00-5--
    Glucosamine2-Amino-2-deoxy-D-glucopyranose (see all 10)3416-24-8--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    10/12 DrugBank Compounds for TNF (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Infliximab-- 170277-31-3targetinhibitor15691299 16622728 11752352 15691217 12110154 17642244 15481318 16052578 16456024 15674127 15804598
    Adalimumab-- 331731-18-1targetantibody11752352 15200343 12044041 14532145 15022409 15046527
    EtanerceptCD120b (see all 7)185243-69-0targetantibody10375846 10206649 10405518 10338381 11752352 10357816
    Thalidomidealpha-phthalimidoglutarimide (see all 5)50-35-1targetinhibitor12167383 12105857 12046682 12113124 11752352 12102294
    AmrinoneAmrinona [inn-spanish] (see all 4)60719-84-8targetinhibitor1611705 10444479 10075051 11805217 11969359
    ChloroquineChloraquine (see all 6)54-05-7target--16418198 16761500 17456179 16870179 16670522
    Clenbuterol-- 37148-27-9targetother/unknown10071758 15021963 17139543 16261833 11193379
    Glucosamine-- 3416-24-8target--16431966 16469053 16445576 12244074 15930455
    Pranlukast-- 103177-37-3targetother/unknown17430359 12801315 12801316
    Certolizumab pegol-- 428863-50-7targetneutralizer23620660

    10/141 Novoseek inferred chemical compound relationships for TNF gene (see all 141)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    infliximab 92.6 1681 16095114 (7), 11961039 (7), 12632433 (7), 15538942 (6) (see all 99)
    etanercept 92 1158 11961039 (8), 19188093 (5), 15005015 (5), 20443835 (5) (see all 99)
    adalimumab 89.5 487 11730333 (10), 19188093 (4), 17343250 (3), 17502862 (3) (see all 99)
    endotoxin 87.3 2305 8687293 (8), 1643887 (7), 9185243 (7), 1770269 (7) (see all 99)
    rantes 83.7 975 16466762 (6), 12663241 (6), 9527395 (6), 12388374 (5) (see all 99)
    pge2 79.9 2340 9298541 (9), 8388910 (8), 1836009 (8), 2378446 (7) (see all 99)
    il 10 79.5 347 19771178 (7), 11166831 (5), 15800006 (5), 12719394 (5) (see all 99)
    pentoxifylline 78.4 990 8189599 (9), 1385797 (8), 7589090 (7), 9486396 (6) (see all 99)
    nitric oxide 76.3 4152 7706743 (11), 8046239 (9), 11566624 (9), 1517576 (8) (see all 99)
    abatacept 74.2 77 19916731 (4), 18590608 (4), 17057043 (3), 18670735 (3) (see all 42)

    5 PharmGKB related drug/compound annotations for TNF gene    About this table
    Drug/compound PharmGKB Annotation

    Search CenterWatch for drugs/clinical trials and news about TNF / TNFA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNF gene: 

    Unigene Cluster for TNF:

    Tumor necrosis factor
    Hs.241570  [show with all ESTs]
    Unigene Representative Sequence: NM_000594
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000449264(uc003nui.3 uc003nuj.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNF
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate TNF (see all 29):
    hsa-miR-549 hsa-miR-875-3p hsa-miR-181c hsa-miR-3141 hsa-miR-4263 hsa-miR-331-3p hsa-miR-301a hsa-miR-181a-2*
    SwitchGear 3'UTR luciferase reporter plasmidTNF 3' UTR sequence
    Inhib. RNA
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TNF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNF
    OriGene clones in human, mouse for TNF (see all 7)
    OriGene ORF clones in mouse, rat for TNF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNF (NM_001192)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNF
    Sirion Biotech Customized lentivirus for stable overexpression of TNF 
                         Customized lentivirus expression plasmids for stable overexpression of TNF 
    OriGene qPCR primer pairs and template standards for TNF
    OriGene qSTAR qPCR primer pairs in human, mouse for TNF
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNF
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNF

    Additional mRNA sequence: 

    AB451492.1 AF043342.1 AF098751.1 AJ227911.1 AK314960.1 BC028148.1 FJ795028.1 HQ201306.2 
    M10988.1 X01394.1 

    6 DOTS entries:

    DT.447264  DT.75172441  DT.100717788  DT.121394302  DT.40132506  DT.95165288 

    24/68 AceView cDNA sequences (see all 68):

    CA307225 BM844832 CD364761 CA310368 BM831593 NM_000594 BG232086 X01394 
    BM762686 BM842415 BC028148 CA308256 CA309711 BI910312 AI242177 CD368116 
    CD364988 CA309509 BM922481 CD367845 BI908079 CD367664 BM906148 CA307429 

    GeneLoc Exon Structure

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNF expression in normal human tissues (normalized intensities)      TNF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    TNF Expression
    About this image

    TNF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Kupffer Cells Sinusoids
             Bone marrow-derived hematopoietic stem cells
             cd31+ cells   
     Neural Tube (Nervous System)
     Trophoblast (Extraembryonic Tissues)
             8-Cell Embryo Morula
     Endothelium (Cardiovascular System)
             cd31+ cells   
     Liver (Hepatobiliary System)
             Kupffer Cells Sinusoids

    See TNF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNF

    SOURCE GeneReport for Unigene cluster: Hs.241570
        SABiosciences Expression via Pathway-Focused PCR Arrays including TNF (see all 50): 
              Lung Cancer in human mouse rat
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Lymphoma in human mouse rat

    OriGene qPCR primer pairs and template standards for TNF
    OriGene qSTAR qPCR primer pairs in human, mouse for TNF
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNF
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNF
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNF
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TNF gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Tnf1 , 5 tumor necrosis factor1, 5 82.9(n)1
      17 (18.59 cM)5
    219261  NM_013693.21  NP_038721.11 
    (Anolis carolinensis)
    Reptilia --
    1 ↔ many
    1 ↔ many
    (Danio rerio)
    Actinopterygii tnfb6
    tumor necrosis factor b (TNF superfamily, member 2...
    tumor necrosis factor a (TNF superfamily, member 2...
    many ↔ many
    many ↔ many

    ENSEMBL Gene Tree for TNF (if available)
    TreeFam Gene Tree for TNF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68)
    About This Section
    Paralogs for TNF gene
    FASLG2  TNFSF152  LTA2  TNFSF142  
    2 SIMAP similar genes for TNF using alignment to 5 protein entries:     TNFA_HUMAN (see all proteins):
    LTA    FASLG

    TNF for paralogs           About GeneDecksing

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: TNFA_HUMAN, P01375
    Polymorphism: Genetic variations in TNF influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424]
    Polymorphism: Genetic variations in TNF are involved in susceptibility to malaria [MIM:611162]

    10/131 SNPs in TNF are shown (see all 131)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 6 posSequence#AA
    C,F,H--31459428(+) CCCCCC/ACTTAA 1 -- us2k135Minor allele frequency- A:0.14NS MN NA EA WA 4098
    C,F--31459428(+) CCCCCC/ACTTAA 1 -- us2k11Minor allele frequency- A:0.15NS 158
    C,F--31459434(+) CTTAAC/TGAAGA 1 -- us2k130Minor allele frequency- T:0.09NS MN NA EA WA 2962
    C,F,H--31459485(+) AGGACC/TTCCAG 1 -- us2k17Minor allele frequency- T:0.01NS EA NA 808
    C,F,H--31459509(+) GGGACG/ATTTAA 1 -- us2k19Minor allele frequency- A:0.00MN NS EA 804
    C,F,H--31459532(+) ACACAC/ATGGGG 1 -- us2k16Minor allele frequency- A:0.00NS EA 740
    C,H--31459607(-) ATGCTG/TGTTTC 1 -- us2k14Minor allele frequency- T:0.00NS EA 406
    C--31459643(-) AGGCCC/TTCTTC 1 -- us2k10--------
    C,F--31459645(+) AGAAGG/ACCTGC 1 -- us2k13Minor allele frequency- A:0.01NS NA 332
    C,F--31459719(+) CTGCTA/CCCCCC 1 -- us2k14Minor allele frequency- C:0.02NS NA 334

    HapMap Linkage Disequilibrium report for TNF (31543344 - 31546113 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TNF:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830627CNV Loss17160897
    nsv462870CNV Loss19166990
    nsv470809CNV Loss18288195
    nsv884418CNV Gain21882294

    Human Gene Mutation Database (HGMD): TNF
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TNF
    DNA2.0 Custom Variant and Variant Library Synthesis for TNF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 191160   
    OMIM disorders: 611162  600807  157300  
    UniProtKB/Swiss-Prot: TNFA_HUMAN, P01375
  • Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with
    psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive,
    erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis
    characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which
    involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that
    can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive
    condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • 736 diseases for TNF (see first 20):    About MalaCards
    aphthous stomatitis    magic syndrome    mycobacterium chelonae    meliodosis
    periodic fever, aphthous stomatitis, pharyngitis and adenitis    new daily-persistent headache    hepatosplenic t-cell lymphoma    visual agnosia
    uveitis    stomatitis    mucocutaneous leishmaniasis    tuberculous uveitis
    adult pulmonary langerhans cell histiocytosis    central nervous system vasculitis    punctate inner choroidopathy    pediatric ulcerative colitis
    central nervous system leukemia    mycobacterium marinum    tuberculoid leprosy    clostridium sordellii
    dissecting cellulitis of the scalp    oral tuberculosis    spondylarthropathy    toxic shock syndrome
    panuveitis    staphylococcal toxic shock syndrome    actinic prurigo    idiopathic recurrent pericarditis
    maternally inherited leigh syndrome    miller fisher syndrome    aspiration pneumonitis    lymphangiosarcoma
    epidural abscess    agnosia    mycobacterium abscessus    migraine without aura
    foot drop    benign migratory glossitis    granulomatous dermatitis    cryptogenic organizing pneumonia
    normophosphatemic familial tumoral calcinosis    ulcerative colitis    vasculitis    complex regional pain syndrome type 1
    cellulitis    cat-scratch disease    spermatocele    refractory anemia with excess blasts
    hiv-1 viremia    branch retinal artery occlusion    granuloma annulare    adult dermatomyositis
    alcoholic hepatitis    hemorrhagic fever    pleural tuberculosis    familial tumoral calcinosis
    glossitis    charcot-marie-tooth neuropathy type 2a    farmer's lung    bagassosis
    paresthesia    sarcoidosis    streptococcal toxic-shock syndrome    skin conditions
    blau syndrome    generalized pustular psoriasis    cold agglutinin disease    hyper-igd syndrome
    monoclonal gammopathy of uncertain significance    calcinosis    multicentric reticulohistiocytosis    granulocytopenia
    coronary aneurysm    lymphocytic vasculitis    idiopathic achalasia    graft versus host disease
    rheumatic disease    rheumatoid vasculitis    bullous skin disease    retinal vasculitis
    bell's palsy    intermediate uveitis    melancholia    palindromic rheumatism
    chronic progressive multiple sclerosis    erysipelas    orchitis    parametritis
    vulvar vestibulitis syndrome    sapho syndrome    schnitzler syndrome    rapidly progressive glomerulonephritis
    listeriosis    radiation proctitis    pharyngitis    mycobacterium avium complex disease
    leishmaniasis    scleritis    common variable immune deficiency    pediatric systemic lupus erythematosus
    sympathetic ophthalmia    large granular lymphocyte leukemia    compartment syndrome    alopecia universalis
    t-cell large granular lymphocyte leukemia    leukostasis    dengue disease    perinatal necrotizing enterocolitis
    insulin resistance    nephropathia epidemica    crimean-congo hemorrhagic fever    idiopathic pulmonary alveolar proteinosis
    arthus reaction    microscopic colitis    dengue shock syndrome    subacute cutaneous lupus erythematosus
    tuberculosis    skin disease    posterior uveitis    multidrug-resistant tuberculosis
    cysticercosis    pulpitis    burning mouth syndrome    weill-marchesani syndrome
    thyroid lymphoma    hepatitis d    leprosy    demyelinating polyneuropathy
    retinal artery occlusion    chronic inflammatory demyelinating polyneuropathy    familial mediterranean fever    endophthalmitis
    epstein-barr virus-associated gastric carcinoma    intestinal disease    cardiac sarcoidosis    joint disorders
    eales disease    coronary restenosis    lymphatic system disease    crohn's disease
    spondylitis    monocytic leukemia    aids dementia complex    aseptic meningitis
    acute disseminated encephalomyelitis    acute myelomonocytic leukemia    post-transplant lymphoproliferative disease    hepatorenal syndrome
    cytomegalovirus retinitis    tuberculous meningitis    chorioamnionitis    jaundice
    systemic onset juvenile idiopathic arthritis    polyneuropathy    alveolar echinococcosis    hidradenitis suppurativa
    familial partial lipodystrophy    hidradenitis    intervertebral disc disease    early-onset schizophrenia
    classic kaposi sarcoma    acute graft versus host disease    extrinsic allergic alveolitis    cheilitis
    actinic cheilitis    ocular cicatricial pemphigoid    metabolic syndrome x    cicatricial pemphigoid
    periapical granuloma    meningitis    intrauterine infections    intracranial hypertension
    periventricular leukomalacia    leukomalacia    malaria    pouchitis
    charcot-marie-tooth neuropathy type 2    lepromatous leprosy    coronary artery aneurysm    systolic heart failure
    retinal ischemia    subacute thyroiditis    cardiogenic shock    erythema multiforme
    paratyphoid fever    omenn syndrome    charcot-marie-tooth neuropathy    bladder cancer susceptibility
    pneumonia    drug-induced hepatitis    sialadenitis    periodontitis
    adult respiratory distress syndrome    proctitis    trachoma    cryptococcosis
    intestinal pseudo-obstruction    meningococcal infection    poems syndrome    renovascular hypertension
    autoimmune myocarditis    microscopic polyangiitis    panniculitis    diabetic polyneuropathy
    septic arthritis    asbestosis    collagen disease    preterm premature rupture of the membranes
    critical limb ischemia    obstructive lung disease    echinococcosis    thoracic aortic aneurysm
    histoplasmosis    peripheral primitive neuroectodermal tumor    psoriatic arthritis    dermatitis
    pyoderma gangrenosum    acute pyelonephritis    diffuse panbronchiolitis    pyoderma
    cerebral aneurysms    meningoencephalitis    lymphocytic choriomeningitis    encephalomyelitis
    pemphigus    alopecia    spotted fever    congenital heart block
    acrodermatitis    onchocerciasis    psoriasis    poliomyelitis
    progressive multifocal leukoencephalopathy    lambert-eaton myasthenic syndrome    ehrlichiosis    myotonic dystrophy type 1
    bronchogenic carcinoma    molluscum contagiosum    behcet's disease    paracoccidioidomycosis
    hereditary breast cancer    autoimmune pancreatitis    avian influenza    dermatitis herpetiformis
    desmoid tumor    complex regional pain syndrome    mixed cryoglobulinemia    pericarditis
    short bowel syndrome    eosinophilic pneumonia    fascioliasis    multiple sclerosis
    influenza    herpes zoster    neonatal jaundice    membranous glomerulonephritis
    epithelioid sarcoma    liver disease    adult-onset still's disease    toxic epidermal necrolysis
    pulmonary alveolar proteinosis    pemphigus foliaceus    polymyalgia rheumatica    iron deficiency anemia
    tooth agenesis    refractory anemia    bacterial vaginosis    hemorrhagic fever with renal syndrome
    oral submucous fibrosis    severe pre-eclampsia    hepatic encephalopathy    stevens-johnson syndrome
    chronic venous leg ulcers    severe congenital neutropenia    achalasia    ankylosing spondylitis
    allergic encephalomyelitis    back pain    takayasu's arteritis    nephrosis
    cerebral malaria    rheumatoid arthritis, association with    fasciitis    cutaneous lupus erythematosus
    headache    q fever    nervous system disease    pre-eclampsia
    rheumatic fever    anterior uveitis    newcastle disease    lichen sclerosus
    ileus    nonalcoholic steatohepatitis    glomerulonephritis    silicosis
    retinal vein occlusion    mixed connective tissue disease    intrahepatic cholestasis of pregnancy    h. pylori infection
    varicose veins    filariasis    dermatomyositis    aortic aneurysm
    pleurisy    pyelonephritis    subacute sclerosing panencephalitis    glucocorticoid resistance
    eclampsia    pneumoconiosis    migraine    guillain-barre syndrome
    optic neuritis    crescentic glomerulonephritis    acute monocytic leukemia    middle ear cholesteatoma
    food allergy    klebsiella    typhoid fever    brucellosis
    sleep disorder    autoimmune hemolytic anemia    congenital hypothyroidism    ovarian epithelial cancer
    bacterial meningitis    fabry disease    arthropathy    cholecystitis
    lipodystrophy    hypercalcemia    cryoglobulinemia    clostridium difficile
    myocarditis    macroglobulinemia    bulimia nervosa    japanese encephalitis
    dementia    spondyloarthropathy    mouth disease    periodontal disease
    neuritis    atrophic gastritis    cholesteatoma    acute liver failure
    alcoholic liver cirrhosis    arteriovenous malformation    juvenile rheumatoid arthritis    contact dermatitis
    langerhans-cell histiocytosis    waldenstrom macroglobulinemia    paget's disease of bone    vesicoureteral reflux
    alpha 1-antitrypsin deficiency    deep vein thrombosis    agammaglobulinemia    chronic granulomatous disease
    hepatitis e    paine syndrome    allergic contact dermatitis    mumps
    aortic valve stenosis    cerebritis    kaposi's sarcoma    rheumatoid arthritis
    primitive neuroectodermal tumor    pulmonary sarcoidosis    appendicitis    lyme disease
    chronic graft versus host disease    gingival overgrowth    retinopathy of prematurity    pulmonary edema
    myotonic dystrophy    angiomyolipoma    hyperuricemia    familial combined hyperlipidemia
    lupus erythematosus    reactive arthritis    hemophagocytic lymphohistiocytosis    plasmodium falciparum malaria
    bronchiolitis obliterans    pemphigus vulgaris    osteomyelitis    gastroduodenitis
    cutaneous leishmaniasis    pancreatic diseases    klinefelter's syndrome    synovitis
    t-cell leukemia    relapsing-remitting multiple sclerosis    obstructive jaundice    febrile seizures
    obsessive-compulsive disorder    lipoma    duodenal ulcer    narcolepsy
    retinal detachment    gingivitis    end stage renal failure    tuberous sclerosis complex
    focal segmental glomerulosclerosis    arthritis    leptospirosis    bronchiectasis
    visceral leishmaniasis    hairy cell leukemia    proliferative vitreoretinopathy    wilson disease
    intrahepatic cholestasis    inflammatory bowel disease    hemophilia    fibromyalgia
    hemolytic-uremic syndrome    bronchiolitis    portal hypertension    childhood leukemia
    bipolar i disorder    alcoholism    histiocytosis    hemolytic anemia
    balanitis    systemic lupus erythematosus    disseminated intravascular coagulation    essential thrombocythemia
    mastitis    connective tissue disease    alopecia areata    primary hyperparathyroidism
    aggressive periodontitis    hyperandrogenism    pterygium    osteopetrosis
    primary sclerosing cholangitis    anoxia    urethritis    sclerosing cholangitis
    vascular dementia    gaucher's disease    peptic ulcer    aspergillosis
    biliary tract cancer    congenital diaphragmatic hernia    adrenoleukodystrophy    merkel cell carcinoma
    hypertension    cholangitis    peripheral t-cell lymphoma    hepatitis b virus infection
    irritable bowel syndrome    bronchopulmonary dysplasia    rubella    leukodystrophy
    ectodermal dysplasia    amyloidosis    pulmonary tuberculosis    anemia
    differentiating neuroblastoma    familial hypercholesterolemia    gastric ulcer    thrombosis
    duodenitis    neutropenia    antiphospholipid syndrome    kidney cancer
    lactic acidosis    hepatitis a    leukopenia    motor neuron disease
    oral lichen planus    obesity    hematopoietic stem cell transplantation    hypothyroidism
    sleep apnea    breast disease    human immunodeficiency virus infectious disease    common variable immunodeficiency
    wegener's granulomatosis    sickle cell anemia    severe acute respiratory syndrome    breast adenocarcinoma
    sudden infant death syndrome    proliferative diabetic retinopathy    growth hormone deficiency    congestive heart failure
    obesity, association with    cystitis    werner syndrome    bronchitis
    respiratory failure    hepatitis    chronic fatigue syndrome    biliary atresia
    myelofibrosis    hepatopulmonary syndrome    multiple system atrophy    gastritis
    neuropathy    hernia    open-angle glaucoma    glucose intolerance
    cerebral palsy    primary open angle glaucoma    acquired immunodeficiency syndrome    hepatitis c
    kawasaki disease    acute lymphocytic leukemia    toxic encephalopathy    viral hepatitis
    otitis media    acromegaly    lichen planus    hemochromatosis
    hyperparathyroidism    aplastic anemia    interstitial lung disease    sensorineural hearing loss
    keratitis    pandas    bullous pemphigoid    giant cell tumor
    diphtheria    soft tissue sarcoma    diabetic retinopathy    chronic obstructive pulmonary disease
    gallbladder cancer    cerebrovascular disease    gestational diabetes    schistosomiasis
    polymyositis    asthma    dengue hemorrhagic fever    autoimmune hepatitis
    uremia    eczema    urticaria    eye disease
    smallpox    venous thromboembolism    allergic asthma    cervical intraepithelial neoplasia
    esophagitis    cutaneous malignant melanoma    thromboembolism    liver cirrhosis
    acne    fatty liver disease    acute pancreatitis    malignant pleural mesothelioma
    tetanus    patent ductus arteriosus    myasthenia gravis    hypertriglyceridemia
    ischemic heart disease    hypercholesterolemia    osteoarthritis    glaucoma
    hypersensitivity reaction type ii disease    trypanosomiasis    fibrosarcoma    cerebral infarction
    breast cancer susceptibility    type 1 diabetes    lupus nephritis    oligodendroglioma
    cytomegalovirus infection    morbid obesity    endocarditis    vitiligo
    hyperthyroidism    follicular lymphoma    hypertrophic cardiomyopathy    noma
    sickle cell disease    hypogonadism    sarcoma    spinal cord injury
    anaplastic large cell lymphoma    toxoplasmosis    retinitis    neurologic diseases
    hepatitis b    hiv type 1    autoimmune thyroiditis    tuberous sclerosis
    major depressive disorder    hypoglycemia    idiopathic pulmonary fibrosis    chagas disease
    human t-cell leukemia virus type 1    abdominal aortic aneurysm    pulmonary fibrosis    ataxia telangiectasia
    neuroblastoma    cutaneous t cell lymphoma    mood disorder    peripheral neuropathy
    thalassemia    nephritis    germ cell tumors    stomach cancer
    ischemia    epididymitis    pituitary tumors    atopy
    adenoiditis    adult t-cell leukemia    endotheliitis    insulinoma
    thrombocytopenia    neuroendocrine tumor    kidney disease    cholestasis
    primary biliary cirrhosis    lateral sclerosis    amyotrophic lateral sclerosis    diabetes mellitus
    mantle cell lymphoma    polycystic kidney disease    cystic fibrosis    cervicitis
    graves' disease    acute promyelocytic leukemia    tonsillitis    thyroiditis
    leukemia    pancreatitis    melanoma    vaginitis
    purpura    sjogren's syndrome    hepatoblastoma    type 1 diabetes mellitus
    autism spectrum disorder    dilated cardiomyopathy    nephrotic syndrome    allergic rhinitis
    chondrosarcoma    diarrhea    b-cell chronic lymphocytic leukemia    rhinitis
    scleroderma    brain disease    gout    alcohol dependence
    measles    brain injury    celiac disease    polycystic ovary syndrome
    burkitt's lymphoma    metabolic disorders    adenocarcinoma    vaccinia
    gastric adenocarcinoma    peritonitis    sinusitis    anorexia nervosa
    atopic dermatitis    encephalitis    papillary thyroid carcinoma    wilms tumor
    atherosclerosis    cataract    leiomyoma    pheochromocytoma
    non-small cell lung carcinoma    acute myocardial infarction    colon adenocarcinoma    cholera
    choriocarcinoma    oral cancer    coronary heart disease    hyperglycemia
    basal cell carcinoma    diffuse large b-cell lymphoma    myeloid leukemia    myelodysplastic syndromes
    fanconi's anemia    b-cell lymphomas    macular degeneration    rhabdomyosarcoma
    myocardial infarction    squamous cell carcinoma    endometriosis    vascular disease
    cytochrome p450    essential hypertension    pertussis    chronic myeloid leukemia
    non-hodgkin lymphoma    malignant glioma    thyroid cancer    herpes simplex
    laryngitis    choroiditis    acute leukemia    blindness
    esophageal adenocarcinoma    hodgkin's lymphoma    esophageal cancer    breast cancer
    myopathy    ataxia    multiple myeloma    down syndrome
    lung adenocarcinoma    infertility    esophageal squamous cell carcinoma    oral squamous cell carcinoma
    nasopharyngitis    astrocytoma    retinoblastoma    acute lymphoblastic leukemia
    myeloma    cholangiocarcinoma    lymphoblastic leukemia    osteosarcoma
    acute myeloid leukemia    cervical cancer    chronic lymphocytic leukemia    ovarian cancer
    renal cell carcinoma    parkinson's disease    glioblastoma    gastric cancer
    adenoma    prostatitis    schizophrenia    alzheimer's disease
    colon cancer    hypoxia    pancreatic cancer    lung cancer
    neuronitis    hepatocellular carcinoma    colorectal cancer    prostate cancer

    20/24 diseases from the University of Copenhagen DISEASES database for TNF (see all 24):
    Rheumatoid arthritis     Crohn's disease     Cancer     Hypersensitivity reaction type II disease
    Vascular disease     Malaria     Psoriasis     Psoriatic arthritis
    Connective tissue disease     Tuberculosis     Ankylosing spondylitis     Asthma
    Multiple sclerosis     Peritonitis     Diabetes mellitus     Liver disease
    Pneumonia     Ulcerative colitis     Uveitis     Kidney disease

    TNF for disorders           About GeneDecksing

    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/96 Novoseek inferred disease relationships for TNF gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 99 80542 15626980 (12), 1595815 (11), 2374209 (11), 10561634 (10) (see all 99)
    tumors 96.4 68579 15626980 (12), 1595815 (11), 2374209 (11), 10561634 (10) (see all 99)
    inflammation 92.2 3272 17482668 (5), 20439544 (5), 7737534 (4), 9042105 (4) (see all 99)
    rheumatoid arthritis 90.1 2641 1802490 (5), 15879156 (4), 8329189 (4), 19560810 (4) (see all 99)
    arthritis psoriatic 79 279 16284098 (4), 9326391 (4), 15838232 (3), 14678719 (3) (see all 99)
    sepsis 78.9 1166 1860332 (7), 15526005 (6), 2064171 (5), 8403981 (5) (see all 99)
    tumor necrosis factor receptor-associated periodic syndrome 78.8 119 12352631 (2), 15689926 (2), 18347298 (2), 15492850 (2) (see all 82)
    spondylitis ankylosing 77.7 312 9704649 (4), 15838232 (3), 17414952 (3), 16763453 (3) (see all 99)
    shock septic 77.7 621 9366763 (8), 2285204 (5), 8318801 (5), 10966243 (4) (see all 99)
    arthritis 77.5 684 8033415 (5), 9585810 (5), 7589090 (5), 8222316 (4) (see all 99)

    Genetic Association Database (GAD): TNF
    Human Genome Epidemiology (HuGE) Navigator: TNF (2475 documents)
    Tumor Gene Database (TGDB): TNF

    Export disorders for TNF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNF gene, integrated from 9 sources (see all 17042):
    (articles sorted by number of sources associating them with TNF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria. (PubMed id 10369255)1, 2, 4, 9 Knight J.C....Kwiatkowski D. (1999)
    2. Association of TNF-alpha promoter polymorphisms with the clearance of hepatitis B virus infection. (PubMed id 12915457)1, 2, 4 Kim Y.J.... Shin H.D. (2003)
    3. Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity. (PubMed id 12746914)1, 2, 4 Balding J.... FitzGerald O. (2003)
    4. Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. (PubMed id 6392892)1, 2, 3 Pennica D.... Goeddel D.V. (1984)
    5. The tumor necrosis factor polymorphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality. (PubMed id 19242354)1, 4, 9 Read R.C....Wilson A.G. (2009)
    6. Association between the level of circulating bioactive tumor necrosis factor alpha and the tumor necrosis factor alpha gene polymorphism at -308 in patients with rheumatoid arthritis treated with a tumor necrosis factor alpha inhibitor. (PubMed id 18438841)1, 4, 9 Marotte H....Miossec P. (2008)
    7. TNF polymorphism and bronchoalveolar lavage cell TNF-alpha levels in chronic beryllium disease and beryllium sensitization. (PubMed id 17208287)1, 4, 9 Sato H....Maier L.A. (2007)
    8. TNF-alpha gene promoter polymorphism at nucleotide -308 and the inflammatory response and oxidative stress induced by cardiac surgery: role of heart failure and medical treatment. (PubMed id 18450464)1, 4, 9 Galinanes M....Hadjinikolaou L. (2008)
    9. TNFalpha genotype affects TNFalpha release, insulin sensitivity and the severity of liver disease in HCV chronic hepatitis. (PubMed id 16143422)1, 4, 9 Valenti L....Fargion S. (2005)
    10. Association of bladder tumors and GA genotype of -308 nucleotide in tumor necrosis factor-alpha promoter with greater tumor necrosis factor-alpha expression. (PubMed id 15533517)1, 4, 9 Jeong P....Kim W.J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
    Free Text  

      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7124 HGNC: 11892 AceView: TNF Ensembl:ENSG00000232810 euGenes: HUgn7124
    ECgene: TNF Kegg: 7124 H-InvDB: TNF

    (According to HUGE)
    About This Section

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    PharmGKB entry for TNF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNF gene:
    Search GeneIP for patents involving TNF

    Licensable Technologies for TNF gene:
    Weizmann Institute:Novel anti-inflammatory and immunomodulatory agents based on oleyl alcohols
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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