Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TNF Gene

protein-coding   GIFtS: 73
GCID: GC06P031543

Tumor Necrosis Factor

(Previous names: tumor necrosis factor (TNF superfamily, member 2))
(Previous symbol: TNFA)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tumor Necrosis Factor1 2     Tumor Necrosis Factor (TNF Superfamily, Member 2)1
TNFA1 2 3 5     DIF2
Tumor Necrosis Factor Ligand Superfamily Member 22 3     APC1 Protein2
TNF-a2 3     cachectin2
TNF-alpha2 3     TNF, Macrophage-Derived2
TNFSF22 3     TNF, Monocyte-Derived2
Member 21     Tumor Necrosis Factor-Alpha2
TNF Superfamily1     Cachectin3

External Ids:    HGNC: 118921   Entrez Gene: 71242   Ensembl: ENSG000002328107   OMIM: 1911605   UniProtKB: P013753   

Export aliases for TNF gene to outside databases

Previous GC identifers: GC06P031606 GC06P031597 GC06P031314 GC06P031647 GC06P031652 GC06P031330


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TNF Gene:
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF)
superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its
receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of
biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.
This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance,
and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TNF Gene:
TNF (tumor necrosis factor) is a protein-coding gene. Diseases associated with TNF include aphthous stomatitis, and vascular dementia. GO annotations related to this gene include cytokine activity and identical protein binding. An important paralog of this gene is FASLG.

UniProtKB/Swiss-Prot: TNFA_HUMAN, P01375
Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can
induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by
stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions
it can stimulate cell proliferation and induce cell differentiation
Function: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells

summary for TNF Gene:
NF-kappaB (nuclear factor-kappa B) is a rapidly acting primary transcription factor found in all cell types.
It is involved in cellular responses to stimuli such as cytokines and stress and plays a key role in
regulating the immune response to infection. In unstimulated cells NF-kappaB dimers are sequestered
inactively in the cytoplasm by a protein complex called inhibitor of kappa B (IkappaB). IkappaB inactivates
NF-kappaB by masking the nuclear localization signals (NLS). Activation of NF-kappaB occurs via degradation
of IkappaB, a process that is initiated by its phosphorylation by IkappaB kinase (IKK). Phosphorylated
IkappaB becomes dissociated from NF-kappaB, unmasking the NLS. Phosphorylation also results in IkappaB
ubiquitination and targeting to the proteasome. NF-kappaB can now enter the nucleus and regulate gene
expression. NF-kappaB turns on expression of IkappaB forming a negative feedback loop.

Gene Wiki entry for TNF (Tumor necrosis factor-alpha) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167246.2  NT_167247.2  
NT_167248.2  NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNF gene promoter:
         c-Fos   p53   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TNF promoter sequence
   Search Chromatin IP Primers for TNF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

TNF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNF gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031543:  view genomic region     (about GC identifiers)

Start:
31,543,344 bp from pter      End:
31,546,113 bp from pter
Size:
2,770 bases      Orientation:
plus strand

Selected alternative locations (see all 7):
Chr6+,NT_167246 2,886,234-2,888,996      Chr6+,NT_167248 2,836,988-2,839,752      Chr6+,NT_167247 2,923,056-2,925,818     
Chr6+,NT_167249 2,874,151-2,876,913      Chr6+,NT_167244 2,859,024-2,860,830      Chr6+,NT_167245 2,828,891-2,831,653     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TNFA_HUMAN, P01375 (See protein sequence)
Recommended Name: Tumor necrosis factor precursor  
Size: 233 amino acids; 25644 Da
Subunit: Homotrimer. Interacts with SPPL2B
Sequence caution: Sequence=AAF71992.1; Type=Frameshift; Positions=91, 157; Sequence=CAA75070.1; Type=Erroneous
gene model prediction;
Selected PDB 3D structures from and Proteopedia for TNF (see all 14):
1A8M (3D)        1TNF (3D)        2AZ5 (3D)        2E7A (3D)        2TUN (3D)        2ZJC (3D)    
Secondary accessions: O43647 Q9P1Q2 Q9UIV3

Explore the universe of human proteins at neXtProt for TNF: NX_P01375

Explore proteomics data for TNF at MOPED

Post-translational modifications: 

  • The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further
    proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF
    intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the
    extracellular space1
  • The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the
    membrane form occurs by binding to soluble TNFRSF1A/TNFR11
  • O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid1
  • Glycosylation2 at Ser80
  • Modification sites at PhosphoSitePlus

  • See TNF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000585.2  
    ENSEMBL proteins: 
     ENSP00000398698  
    Reactome Protein details: P01375

    TNF Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant TNF Protein
    R&D Systems Recombinant & Natural Proteins for TNF (TNF-alpha)
    Enzo Life Sciences proteins for TNF
    OriGene Purified Proteins for TNF
    OriGene Protein Over-expression Lysate for TNF
    OriGene MassSpec for TNF
    OriGene Custom Protein Services for TNF
    GenScript Purified and Recombinant Proteins for TNF
    Novus Biologicals TNF Proteins
    Novus Biologicals TNF Lysate
    Sino Biological Recombinant Protein for TNF
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TNF
    Browse Proteins at Cloud-Clone Corp.

    TNF Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TNF
    R&D Systems Antibodies for TNF (TNF-alpha)
    OriGene Antibodies for TNF
    OriGene Custom Antibody Services for TNF
    Novus Biologicals TNF Antibodies
    Abcam antibodies for TNF
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for TNF
    LSBio Antibodies in human, mouse, rat for TNF

    TNF Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TNF
    R&D Systems Flow Cytometry Kits for TNF (TNF-alpha)         (see all)
    GenScript Custom Assay Services for TNF
    Enzo Life Sciences assays for TNF
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TNFSF: Tumor necrosis factor (ligand) superfamily

    Selected InterPro protein domains (see all 6):
     IPR008064 TNFalpha/TNFSF15
     IPR002959 TNF_alpha
     IPR006052 TNF_dom
     IPR006053 TNF
     IPR008983 Tumour_necrosis_fac-like_dom

    Graphical View of Domain Structure for InterPro Entry P01375

    ProtoNet protein and cluster: P01375

    3 Blocks protein domains:
    IPB002959 Tumour necrosis factor alpha (cachectin) signature
    IPB006052 Tumor Necrosis Factor
    IPB006053 Tumour necrosis factor family signature


    UniProtKB/Swiss-Prot: TNFA_HUMAN, P01375
    Similarity: Belongs to the tumor necrosis factor family


    TNF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNFA_HUMAN, P01375
    Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can
    induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by
    stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions
    it can stimulate cell proliferation and induce cell differentiation
    Function: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells

         Genatlas biochemistry entry for TNF:
    tumor necrosis factor,alpha (cachectin),potent proinflammatory cytokine,involved in inflammatory and immune
    responses,stimulating the sphingomyelinase (SMPD1),enhancing insulin resistance in peripheral tissues of cancer
    patients,susceptibility factor for narcolepsy and myasthenia gravis and cardiac sarcoidosis,with a common
    polymorphism in the promoter region (C->A) associated with reduced circulating levels of TNF,mediating neuronal
    death in injured brain (by inducing resistance to the protective effect of IGF1)

         Summary: 
    During embryonic development, TNF as signaling molecule affects the following cells:
    Liver: Fetal Hepatocytes (Liver Lobule)

    TNF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
                
    Blood: Mature dendritic-like cells, Dendritic-like cells       to see all 2 cells

         Gene Ontology (GO): 6 molecular function terms (see first 5):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI12777399
    GO:0005125cytokine activity IDA10748004
    GO:0005164tumor necrosis factor receptor binding IDA14512626
    GO:0005515protein binding IPI11878931
    GO:0042802identical protein binding IDA14512626
    GO:0044212transcription regulatory region DNA binding IDA17350185
         
    TNF for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TNF:
     Increased cell death in breast 

         Selected MGI mutant phenotypes (inferred from 19 alleles(MGI details for Tnf) (see all 24):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    TNF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TNF: Ltb/TnfLtb/tm1.1Dvk Lta/TnfLta/tm1Eug Tnftm1Jods Lta/TnfLta/tm1Fda Tnftm1Sek Tnftm1Gkl
                                                         Tnftm3Gkl Ltb/Tnf/LtaLtb/Tnf/tm1Dvk Tnftm2.1Gkl Tnftm1Ljo Tnftm1.2Sned Lta/TnfLta/tm1Jods Tnftm2Gkl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNF

    miRNA
    Products:
        
    miRTarBase miRNAs that target TNF:
    hsa-mir-203a (MIRT006857)

    Block miRNA regulation of human, mouse, rat TNF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNF (see all 29):
    hsa-miR-549 hsa-miR-875-3p hsa-miR-181c hsa-miR-3141 hsa-miR-4263 hsa-miR-331-3p hsa-miR-301a hsa-miR-181a-2*
    SwitchGear 3'UTR luciferase reporter plasmidTNF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TNF
    Predesigned siRNA for gene silencing in human, mouse, rat TNF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TNF

    Clone
    Products:
         
    OriGene clones in human, mouse for TNF (see all 6)
    OriGene ORF clones in mouse, rat for TNF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNF (NM_001192)
    Sino Biological Human cDNA Clone for TNF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNF

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TNF
    Browse ESI BIO Cell Lines and PureStem Progenitors for TNF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TNFA_HUMAN, P01375: Cell membrane; Single-pass type II membrane protein
    TNFA_HUMAN, P01375: Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein
    TNFA_HUMAN, P01375: Tumor necrosis factor, soluble form: Secreted
    TNFA_HUMAN, P01375: C-domain 1: Secreted
    TNFA_HUMAN, P01375: C-domain 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    endosome3
    nucleus3
    cytoskeleton2
    cytosol2
    mitochondrion2
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    peroxisome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001891phagocytic cup ISS--
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA10443688
    GO:0005622intracellular ----
    GO:0005886plasma membrane TAS--

    TNF for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TNF About   (see all 99)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TNFR1 Pathway0.56
    Apoptotic Pathways Triggered By HIV10.42
    TNF Signaling0.55
    Apoptosis through Death Receptors0.42
    Apoptosis and survival TNFR1 signaling pathway0.52
    TWEAK Signaling Pathway0.31
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    2Allograft rejection
    Allograft rejection0.86
    Asthma0.46
    Allograft Rejection0.86
    THC Differentiation Pathway0.38
    Type I diabetes mellitus0.69
    Antigen processing and presentation0.36
    Graft-versus-host disease0.65
    3Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    Caspase cascade in apoptosis0.42
    FAS pathway and Stress induction of HSP regulation0.44
    4IL-9 Signaling Pathways
    Immune response IL 9 signaling pathway0.42
    Adipocytokines and Insulin Signaling0.34
    IL-9 Pathway0.36
    5PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for TNF (see all 8)
        NOD-like Receptor Signaling Pathways
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    Adipocytokines & Insulin Signaling
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNF (see all 50)
        Caspase Cascade
    THC Differentiation Pathway
    14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    1 Cell Signaling Technology (CST) Pathway for TNF
        NF-kappaB Signaling

    Selected GeneGo (Thomson Reuters) Pathways for TNF (see all 15)
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Immune response MIF-mediated glucocorticoid regulation
    Apoptosis and survival Caspase cascade
    Immune response MIF in innate immunity response
    Immune response IL-9 signaling pathway

    Selected BioSystems Pathways for TNF (see all 38)
        MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Apoptosis
    Cytokines and Inflammatory Response
    TGF Beta Signaling Pathway

    3 Sino Biological Pathways for TNF
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    2 Reactome Pathways for TNF
        Transcriptional regulation of white adipocyte differentiation
    TNF signaling


    Selected Kegg Pathways  (Kegg details for TNF) (see all 45):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    NF-kappa B signaling pathway
    mTOR signaling pathway
    Apoptosis


    TNF for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNF (see all 50): 
              Lung Cancer in human mouse rat
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Lymphoma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNF (P013751, 2, 3 ENSP000003986984) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF1AP194381, 2, 3, ENSP000001627494EBI-359977,EBI-299451 MINT-48045 MINT-49295 I2D: score=12 STRING: ENSP00000162749
    IKBKGQ9Y6K91, 2, 3EBI-359977,EBI-81279 MINT-8410390 I2D: score=1 
    RBCK1Q9BYM82, 3MINT-8410390 I2D: score=1 
    RNF31Q96EP02, 3MINT-8410390 I2D: score=1 
    TNFAIP3P215802, 3MINT-8410390 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 128):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IDA16280327
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15345745
    GO:0000165MAPK cascade IMP--
    GO:0000185activation of MAPKKK activity IDA15310755
    GO:0000187activation of MAPK activity IDA10748004

    TNF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for TNF
    3 ApexBio Compounds for TNF     About this table
    CompoundAction CAS #
    Lenalidomide (CC-5013)TNF-alfa secretion inhibitor with IC50 of 13 nM[191732-72-6]
    Necrostatin-1Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-alfa-induced necroptosis with EC50 of 490 nM[4311-88-0]
    Pomalidomide (CC-4047)Pomalidomide, previously known as CC-4047 or actimid, is a potent immunomodulatory molecule that exhibits antineoplastic activity for the treatment of hematological malignancies, especially relapsed and refractory multiple myeloma (MM)[19171-19-8]

    Compounds for TNF available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SC 514IKKbeta inhibitor; attenuates NF-kappaB-induced gene expression[354812-17-2]
    Ro 106-9920Inhibitor of NF-kappaB activation[62645-28-7]
    IMD 0354Inhibitor of IKKbeta[978-62-1]
    CelastrolInhibits TNF-alpha-induced NF-kappaB activation[34157-83-0]
    Bay 11-7085Irreversible inhibitor of TNF-alpha-induced IkappaBalpha phosphorylation[196309-76-9]

    4 HMDB Compounds for TNF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Butyric acid1-Butyrate (see all 25)107-92-616142751
    AtorvastatinAtorvastatin acid (see all 4)134523-00-5--
    Glucosamine2-Amino-2-deoxy-D-glucopyranose (see all 10)3416-24-8--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    Selected DrugBank Compounds for TNF (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Infliximab-- 170277-31-3targetinhibitor15691299 16622728 11752352 15691217 12110154 17642244 15481318 16052578 16456024 15674127 15804598
    Adalimumab-- 331731-18-1targetantibody11752352 15200343 12044041 14532145 15022409 15046527
    EtanerceptCD120b (see all 7)185243-69-0targetantibody10375846 10206649 10405518 10338381 11752352 10357816
    Thalidomidealpha-phthalimidoglutarimide (see all 5)50-35-1targetinhibitor12167383 12105857 12046682 12113124 11752352 12102294
    AmrinoneAmrinona [inn-spanish] (see all 4)60719-84-8targetinhibitor1611705 10444479 10075051 11805217 11969359
    ChloroquineChloraquine (see all 6)54-05-7target--16418198 16761500 17456179 16870179 16670522
    Clenbuterol-- 37148-27-9targetother/unknown10071758 15021963 17139543 16261833 11193379
    Glucosamine-- 3416-24-8target--16431966 16469053 16445576 12244074 15930455
    Pranlukast-- 103177-37-3targetother/unknown17430359 12801315 12801316
    Certolizumab pegol-- 428863-50-7targetneutralizer23620660

    Selected Novoseek inferred chemical compound relationships for TNF gene (see all 141)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    infliximab 92.6 1681 16095114 (7), 11961039 (7), 12632433 (7), 15538942 (6) (see all 99)
    etanercept 92 1158 11961039 (8), 19188093 (5), 15005015 (5), 20443835 (5) (see all 99)
    adalimumab 89.5 487 11730333 (10), 19188093 (4), 17343250 (3), 17502862 (3) (see all 99)
    endotoxin 87.3 2305 8687293 (8), 1643887 (7), 9185243 (7), 1770269 (7) (see all 99)
    rantes 83.7 975 16466762 (6), 12663241 (6), 9527395 (6), 12388374 (5) (see all 99)
    pge2 79.9 2340 9298541 (9), 8388910 (8), 1836009 (8), 2378446 (7) (see all 99)
    il 10 79.5 347 19771178 (7), 11166831 (5), 15800006 (5), 12719394 (5) (see all 99)
    pentoxifylline 78.4 990 8189599 (9), 1385797 (8), 7589090 (7), 9486396 (6) (see all 99)
    nitric oxide 76.3 4152 7706743 (11), 8046239 (9), 11566624 (9), 1517576 (8) (see all 99)
    abatacept 74.2 77 19916731 (4), 18590608 (4), 17057043 (3), 18670735 (3) (see all 42)

    5 PharmGKB related drug/compound annotations for TNF gene    About this table
    Drug/compound PharmGKB Annotation
    abacavirCA  
    adalimumabCA  
    carbamazepineCA  
    etanerceptCA  
    infliximabCA  



    TNF for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TNF gene: 
    NM_000594.3  

    Unigene Cluster for TNF:

    Tumor necrosis factor
    Hs.241570  [show with all ESTs]
    Unigene Representative Sequence: NM_000594
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000449264(uc003nui.3 uc003nuj.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TNF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNF (see all 29):
    hsa-miR-549 hsa-miR-875-3p hsa-miR-181c hsa-miR-3141 hsa-miR-4263 hsa-miR-331-3p hsa-miR-301a hsa-miR-181a-2*
    SwitchGear 3'UTR luciferase reporter plasmidTNF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TNF
    Predesigned siRNA for gene silencing in human, mouse, rat TNF
    Clone
    Products:
         
    OriGene clones in human, mouse for TNF (see all 6)
    OriGene ORF clones in mouse, rat for TNF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNF (NM_001192)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNF
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TNF
    OriGene qSTAR qPCR primer pairs in human, mouse for TNF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNF
      QuantiTect SYBR Green Assays in human, mouse, rat TNF
      QuantiFast Probe-based Assays in human, mouse, rat TNF

    Additional mRNA sequence: 

    AB451492.1 AF043342.1 AF098751.1 AJ227911.1 AK314960.1 BC028148.1 FJ795028.1 HQ201306.2 
    M10988.1 X01394.1 

    6 DOTS entries:

    DT.447264  DT.75172441  DT.100717788  DT.121394302  DT.40132506  DT.95165288 

    Selected AceView cDNA sequences (see all 68):

    CA307225 BM831593 BM844832 CA310368 NM_000594 BM762686 BM842415 CD364761 
    BC028148 X01394 BG232086 M10988 BI910312 CA307429 CD367625 CD366187 
    CD368116 CA308256 CD368929 AI088239 BI908079 CD367794 CA748748 CD367664 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TNF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCCCCCTG
    TNF Expression
    About this image


    TNF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Kupffer Cells Sinusoids
             Angiogenic cell precursor
     
     Liver (Hepatobiliary System)
             Kupffer Cells Sinusoids
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Zygote (Early Embryonic Tissues)
             8-Cell Embryo Morula
    TNF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.241570
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNF (see all 50): 
              Lung Cancer in human mouse rat
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Lymphoma in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TNF
    OriGene qSTAR qPCR primer pairs in human, mouse for TNF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNF
    QuantiTect SYBR Green Assays in human, mouse, rat TNF
    QuantiFast Probe-based Assays in human, mouse, rat TNF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TNF gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnf1 , 5 tumor necrosis factor1, 5 82.9(n)1
    80.17(a)1
      17 (18.59 cM)5
    219261  NM_013693.31  NP_038721.11 
     351993815 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    38(a)
    37(a)
    1 ↔ many
    1 ↔ many
    2(195685950-195692186)
    2(195674701-195679824)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tnf1 tumor necrosis factor 50.43(n)
    34.36(a)
      100134991  NM_001113671.1  NP_001107143.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tnfa6
    tnfb6
    tumor necrosis factor a (TNF superfamily, member 2...
    tumor necrosis factor b (TNF superfamily, member 2...
    26(a)
    24(a)
    many ↔ many
    many ↔ many
    19(27505097-27509684) ENSDARG00000009511
    15(33995840-33998916) ENSDARG00000013598


    ENSEMBL Gene Tree for TNF (if available)
    TreeFam Gene Tree for TNF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TNF gene
    FASLG2  TNFSF152  LTA2  TNFSF142  
    2 SIMAP similar genes for TNF using alignment to 4 protein entries:     TNFA_HUMAN (see all proteins):
    LTA    FASLG

    TNF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    TNFA_HUMAN, P01375: Genetic variations in TNF influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424]
    TNFA_HUMAN, P01375: Genetic variations in TNF are involved in susceptibility to malaria [MIM:611162]


    Selected SNPs for TNF (see all 131)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18006301,2
    C,F,H--31459428(+) CCCCCC/ACTTAA 1 -- us2k135Minor allele frequency- A:0.14NS MN NA EA WA 4098
    rs46458361,2
    C,F--31459428(+) CCCCCC/ACTTAA 1 -- us2k11Minor allele frequency- A:0.15NS 158
    rs17997241,2
    C,F--31459434(+) CTTAAC/TGAAGA 1 -- us2k130Minor allele frequency- T:0.09NS MN NA EA WA 2962
    rs42481581,2
    C,F,H--31459485(+) AGGACC/TTCCAG 1 -- us2k17Minor allele frequency- T:0.01NS EA NA 808
    rs49870861,2
    C,F,H--31459509(+) GGGACG/ATTTAA 1 -- us2k19Minor allele frequency- A:0.00MN NS EA 804
    rs42481591,2
    C,F,H--31459532(+) ACACAC/ATGGGG 1 -- us2k16Minor allele frequency- A:0.00NS EA 740
    rs27361961,2
    C,H--31459607(-) ATGCTG/TGTTTC 1 -- us2k14Minor allele frequency- T:0.00NS EA 406
    rs27361951,2
    C--31459643(-) AGGCCC/TTCTTC 1 -- us2k10--------
    rs42481601,2
    C,F--31459645(+) AGAAGG/ACCTGC 1 -- us2k13Minor allele frequency- A:0.01NS NA 332
    rs42481611,2
    C,F--31459719(+) CTGCTA/CCCCCC 1 -- us2k14Minor allele frequency- C:0.02NS NA 334

    HapMap Linkage Disequilibrium report for TNF (31543344 - 31546113 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TNF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830627CNV Loss17160897
    nsv462870CNV Loss19166990
    nsv470809CNV Loss18288195
    nsv884418CNV Gain21882294

    Human Gene Mutation Database (HGMD): TNF
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNF
    DNA2.0 Custom Variant and Variant Library Synthesis for TNF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 191160   
    OMIM disorders: 611162  600807  157300  
    UniProtKB/Swiss-Prot: TNFA_HUMAN, P01375
  • Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with
    psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive,
    erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis
    characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which
    involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that
    can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive
    condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • Selected diseases for TNF (see all 757):    
    About MalaCards
    aphthous stomatitis    vascular dementia    migraine without aura    septic shock
    magic syndrome    mycobacterium chelonae    meliodosis    periodic fever, aphthous stomatitis, pharyngitis and adenitis
    new daily-persistent headache    stomatitis    uveitis    cerebral malaria
    toxic shock syndrome    tuberculoid leprosy    mucocutaneous leishmaniasis    visual agnosia
    tuberculous uveitis    adult pulmonary langerhans cell histiocytosis    central nervous system vasculitis    punctate inner choroidopathy

    Selected diseases from the University of Copenhagen DISEASES database for TNF (see all 24):
    Rheumatoid arthritis     Crohn's disease     Cancer     Hypersensitivity reaction type II disease
    Vascular disease     Malaria     Psoriasis     Psoriatic arthritis
    Connective tissue disease     Tuberculosis     Ankylosing spondylitis     Asthma
    Multiple sclerosis     Peritonitis     Diabetes mellitus     Liver disease
    Pneumonia     Ulcerative colitis     Uveitis     Kidney disease

    TNF for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for TNF gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 99 80542 15626980 (12), 1595815 (11), 2374209 (11), 10561634 (10) (see all 99)
    tumors 96.4 68579 15626980 (12), 1595815 (11), 2374209 (11), 10561634 (10) (see all 99)
    inflammation 92.2 3272 17482668 (5), 20439544 (5), 7737534 (4), 9042105 (4) (see all 99)
    rheumatoid arthritis 90.1 2641 1802490 (5), 15879156 (4), 8329189 (4), 19560810 (4) (see all 99)
    arthritis psoriatic 79 279 16284098 (4), 9326391 (4), 15838232 (3), 14678719 (3) (see all 99)
    sepsis 78.9 1166 1860332 (7), 15526005 (6), 2064171 (5), 8403981 (5) (see all 99)
    tumor necrosis factor receptor-associated periodic syndrome 78.8 119 12352631 (2), 15689926 (2), 18347298 (2), 15492850 (2) (see all 82)
    spondylitis ankylosing 77.7 312 9704649 (4), 15838232 (3), 17414952 (3), 16763453 (3) (see all 99)
    shock septic 77.7 621 9366763 (8), 2285204 (5), 8318801 (5), 10966243 (4) (see all 99)
    arthritis 77.5 684 8033415 (5), 9585810 (5), 7589090 (5), 8222316 (4) (see all 99)

    Genetic Association Database (GAD): TNF
    Human Genome Epidemiology (HuGE) Navigator: TNF (2475 documents)
    Tumor Gene Database (TGDB): TNF

    Export disorders for TNF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TNF gene, integrated from 10 sources (see all 17174):
    (articles sorted by number of sources associating them with TNF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria. (PubMed id 10369255)1, 2, 4, 9 Knight J.C.... Kwiatkowski D. (Nat. Genet. 1999)
    2. Association of TNF-alpha promoter polymorphisms with the clearance of hepatitis B virus infection. (PubMed id 12915457)1, 2, 4 Kim Y.J.... Shin H.D. (Hum. Mol. Genet. 2003)
    3. Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity. (PubMed id 12746914)1, 2, 4 Balding J.... FitzGerald O. (Arthritis Rheum. 2003)
    4. Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. (PubMed id 6392892)1, 2, 3 Pennica D.... Goeddel D.V. (Nature 1984)
    5. The tumor necrosis factor polymorphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality. (PubMed id 19242354)1, 4, 9 Read R.C....Wilson A.G. (Crit. Care Med. 2009)
    6. Association between the level of circulating bioactive tumor necrosis factor alpha and the tumor necrosis factor alpha gene polymorphism at -308 in patients with rheumatoid arthritis treated with a tumor necrosis factor alpha inhibitor. (PubMed id 18438841)1, 4, 9 Marotte H....Miossec P. (Arthritis Rheum. 2008)
    7. TNF polymorphism and bronchoalveolar lavage cell TNF-alpha levels in chronic beryllium disease and beryllium sensitization. (PubMed id 17208287)1, 4, 9 Sato H....Maier L.A. (J. Allergy Clin. Immunol. 2007)
    8. TNF-alpha gene promoter polymorphism at nucleotide -308 and the inflammatory response and oxidative stress induced by cardiac surgery: role of heart failure and medical treatment. (PubMed id 18450464)1, 4, 9 GaliA+anes M....Hadjinikolaou L. (Eur J Cardiothorac Surg 2008)
    9. TNFalpha genotype affects TNFalpha release, insulin sensitivity and the severity of liver disease in HCV chronic hepatitis. (PubMed id 16143422)1, 4, 9 Valenti L....Fargion S. (J. Hepatol. 2005)
    10. Association of bladder tumors and GA genotype of -308 nucleotide in tumor necrosis factor-alpha promoter with greater tumor necrosis factor-alpha expression. (PubMed id 15533517)1, 4, 9 Jeong P....Kim W.J. (Urology 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7124 HGNC: 11892 AceView: TNF Ensembl:ENSG00000232810 euGenes: HUgn7124
    ECgene: TNF Kegg: 7124 H-InvDB: TNF

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TNF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNF Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Tumor_necrosis_factor-alpha
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnf/
    SeattleSNPshttp://pga.gs.washington.edu/data/tnf/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TNF

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TNF gene:
    Search GeneIP for patents involving TNF

    Licensable Technologies for TNF gene:
    Weizmann Institute:Novel anti-inflammatory and immunomodulatory agents based on oleyl alcohols
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant TNF Protein
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TNF
     
     EMD Millipore genomic analysis products

      
     Antibodies for TNF (TNF-alpha)   Browse Cell Culture Products  
     ELISAs for TNF (TNF-alpha)   Flow Cytometry Kits for TNF (TNF-alpha)  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     ELISpot/FluoroSpot Kits/Development Modules for TNF (TNF-alpha)   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Luminex Assays for TNF (TNF-alpha)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for TNF (TNF-alpha)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for TNF (TNF-alpha)  
     OriGene Antibodies for TNF   OriGene RNAi products in human, mouse, rat for TNF  
     OriGene qPCR primer pairs and template standards for TNF   OriGene Protein Over-expression Lysate for TNF  
     OriGene MassSpec something-or-other for TNF   OriGene clones in human, mouse for TNF  
     OriGene qSTAR qPCR primer pairs in human, mouse for TNF   OriGene Purified Protein for TNF  
     OriGene ORF clones in mouse, rat for TNF   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TNF   OriGene Custom Protein Services for TNF  

     
     
     Block miRNA regulation of human, mouse, rat TNF using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TNF
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNF Predesigned siRNA for gene silencing in human, mouse, rat TNF
     QuantiFast Probe-based Assays in human, mouse, rat TNF QuantiTect SYBR Green Assays in human, mouse, rat TNF
     PCR Arrays including human, mouse, rat TNF Search Chromatin IP Primers for TNF
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNF  GeneGlobe Interaction Network for TNF
     Regulatory tfbs in TNF promoter
     GenScript Purified and Recombinant Proteins for TNF GenScript cDNA clones with any tag delivered in your preferred vector for TNF
     GenScript Custom Assay Services for TNF GenScript Custom overexpressing Cell Line Services for TNF
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for TNF
     Proteins for TNF
     Browse Sino Biological Cell Lysates
     cDNA Clones for TNF
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays/Drugs/Proteins for TNF
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TNF antibodies
     TNF proteins
     TNF lysates
     Antibodies for TNF
     See all of Abcam's Antibodies, Kits and Proteins for TNF
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TNF
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for TNF
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNF
     SwitchGear 3'UTR luciferase reporter plasmids for TNF
     SwitchGear Promoter luciferase reporter plasmids for TNF
     ThermoFisher Antibody for TNF
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNF
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNF
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNF
     LSBio Antibodies in human, mouse, rat for TNF
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     ApexBio compounds for TNF
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TNF gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4