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Aliases for TNF Gene

Aliases for TNF Gene

  • Tumor Necrosis Factor 2 3 5
  • Tumor Necrosis Factor Ligand Superfamily Member 2 3 4
  • Cachectin 3 4
  • TNF-Alpha 3 4
  • TNFSF2 3 4
  • TNF-A 3 4
  • TNFA 3 4
  • Tumor Necrosis Factor (TNF Superfamily, Member 2) 2
  • Tumor Necrosis Factor Ligand 1F 3
  • Tumor Necrosis Factor-Alpha 3
  • TNF Superfamily, Member 2 2
  • TNF, Macrophage-Derived 3
  • TNF, Monocyte-Derived 3
  • APC1 Protein 3
  • TNLG1F 3
  • DIF 3

External Ids for TNF Gene

Previous HGNC Symbols for TNF Gene

  • TNFA

Previous GeneCards Identifiers for TNF Gene

  • GC06P031606
  • GC06P031597
  • GC06P031314
  • GC06P031647
  • GC06P031652
  • GC06P031543
  • GC06P031330
  • GC06P031614
  • GC06P031622
  • GC06P031629
  • GC06P031640
  • GC06P031655

Summaries for TNF Gene

Entrez Gene Summary for TNF Gene

  • This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNF Gene

TNF (Tumor Necrosis Factor) is a Protein Coding gene. Diseases associated with TNF include Migraine With Or Without Aura 1 and Asthma. Among its related pathways are TRAF Pathway and Bacterial infections in CF airways. GO annotations related to this gene include identical protein binding and cytokine activity. An important paralog of this gene is LTA.

UniProtKB/Swiss-Prot for TNF Gene

  • Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key Ser-418 residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918).

  • The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.

Tocris Summary for TNF Gene

  • NF-kappaB (nuclear factor-kappa B) is a rapidly acting primary transcription factor found in all cell types. It is involved in the cellular responses to stimuli such as cytokines and stress and plays a key role in regulating the immunological response to infections.

Gene Wiki entry for TNF Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNF Gene

Genomics for TNF Gene

Regulatory Elements for TNF Gene

Enhancers for TNF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G031567 2.1 FANTOM5 Ensembl ENCODE dbSUPER 87.6 +2.9 2852 22.2 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 DDX39B TNF LY6G5B LSM2 DHX16 ATF6B TCF19 PPP1R10 VARS CSNK2B
GH06G031563 1.6 FANTOM5 Ensembl ENCODE 31.2 -12.1 -12090 1.6 HDGF ATF1 ARNT TCF12 GATA2 FOS PAF1 MEF2D SMARCA4 NBN TNF MICB ATP6V1G2 HLA-C HCG23 HLA-B STK19 CLIC1 LST1 LTA
GH06G031562 0.9 FANTOM5 43 -13.3 -13328 0.4 TBL1XR1 DNMT3B ZNF48 ZNF2 RELB ETV6 IKZF2 CREM EGR2 PAF1 TNF ATP6V1G2 STK19 HLA-B LST1 HSPA1B LTA LOC100287329
GH06G031733 1.9 FANTOM5 ENCODE dbSUPER 3.5 +161.9 161888 8.5 MLX CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 LY6G5C LSM2 LY6G5B VARS ABHD16A MICA EHMT2 PRRC2A C4A CLIC1
GH06G031817 1.8 FANTOM5 ENCODE dbSUPER 2.3 +247.2 247213 10.7 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ATF6B SKIV2L LSM2 DDX39B VARS LY6G5B BAG6 STK19B C4A CSNK2B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNF on UCSC Golden Path with GeneCards custom track

Promoters for TNF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195562 433 801 HDGF PKNOX1 FOXA2 TBL1XR1 SIN3A RARA GATA2 ZNF366 RELB IKZF2

Genomic Location for TNF Gene

Chromosome:
6
Start:
31,575,567 bp from pter
End:
31,578,336 bp from pter
Size:
2,770 bases
Orientation:
Plus strand

Genomic View for TNF Gene

Genes around TNF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TNF Gene

  • Protein details for TNF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01375-TNFA_HUMAN
    Recommended name:
    Tumor necrosis factor
    Protein Accession:
    P01375
    Secondary Accessions:
    • O43647
    • Q9P1Q2
    • Q9UIV3

    Protein attributes for TNF Gene

    Size:
    233 amino acids
    Molecular mass:
    25644 Da
    Quaternary structure:
    • Homotrimer. Interacts with SPPL2B.
    SequenceCaution:
    • Sequence=AAF71992.1; Type=Frameshift; Positions=91, 157; Evidence={ECO:0000305}; Sequence=CAA75070.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNF Gene

neXtProt entry for TNF Gene

Post-translational modifications for TNF Gene

  • O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
  • The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
  • The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
  • Glycosylation at posLast=8080
  • Modification sites at PhosphoSitePlus

Other Protein References for TNF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TNF Gene

Domains & Families for TNF Gene

Gene Families for TNF Gene

Graphical View of Domain Structure for InterPro Entry

P01375

UniProtKB/Swiss-Prot:

TNFA_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNF: view

Function for TNF Gene

Molecular function for TNF Gene

GENATLAS Biochemistry:
tumor necrosis factor,alpha (cachectin),potent proinflammatory cytokine,involved in inflammatory and immune responses,stimulating the sphingomyelinase (SMPD1),enhancing insulin resistance in peripheral tissues of cancer patients,susceptibility factor for narcolepsy and myasthenia gravis and cardiac sarcoidosis,with a common polymorphism in the promoter region (C->A) associated with reduced circulating levels of TNF,mediating neuronal death in injured brain (by inducing resistance to the protective effect of IGF1)
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key Ser-418 residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918).
UniProtKB/Swiss-Prot Function:
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.

LifeMap Function Summary for TNF Gene

It affects the following cells:
TNF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for TNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 12777399
GO:0005125 cytokine activity IDA 10748004
GO:0005164 tumor necrosis factor receptor binding IDA 14512626
GO:0005515 protein binding IPI 2848815
GO:0042802 identical protein binding IDA 14512626
genes like me logo Genes that share ontologies with TNF: view
genes like me logo Genes that share phenotypes with TNF: view

Animal Models for TNF Gene

MGI Knock Outs for TNF:

Animal Model Products

  • Taconic Biosciences Mouse Models for TNF

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TNF
  • Applied Biological Materials Clones for TNF

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNF Gene

Localization for TNF Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNF Gene

Cell membrane; Single-pass type II membrane protein.
Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein.
Tumor necrosis factor, soluble form: Secreted.
C-domain 1: Secreted.
C-domain 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNF gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 4
cytoskeleton 3
mitochondrion 3
peroxisome 3
nucleus 3
cytosol 3
endoplasmic reticulum 2
lysosome 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001891 phagocytic cup ISS,IEA --
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 3932069
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with TNF: view

Pathways & Interactions for TNF Gene

genes like me logo Genes that share pathways with TNF: view

Pathways by source for TNF Gene

SIGNOR curated interactions for TNF Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for TNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IDA 16280327
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 1618860
GO:0000165 MAPK cascade IMP 21147091
GO:0000185 activation of MAPKKK activity IDA 15310755
GO:0000187 activation of MAPK activity IDA 10748004
genes like me logo Genes that share ontologies with TNF: view

Drugs & Compounds for TNF Gene

(189) Drugs for TNF Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adalimumab Approved Pharma antibody, Target 494
Etanercept Approved, Investigational Pharma antibody, Target 403
Infliximab Approved Pharma antibody, Target, inhibitor 392
Thalidomide Approved, Investigational, Withdrawn Pharma inhibitor, Target Immunomodulatory agent,sedative drug,angiogenesis inhibitor, Immunomodulatory agents, TNF-alpha synthesis inhibitor 1142
Certolizumab pegol Approved Pharma antibody, Target, neutralizer 127

(71) Additional Compounds for TNF Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cis,trans-5'-Hydroxythalidomide
Ethyl pyruvate
  • Ethyl 2-oxopropanoate
  • Ethyl 2-oxopropionate
  • Ethyl acetylformate
  • Ethyl alpha-ketopropionate
  • Ethyl pyroracemate
617-35-6
IKK 16
1186195-62-9

(5) Tocris Compounds for TNF Gene

Compound Action Cas Number
Bay 11-7085 Irreversible inhibitor of TNF-alpha-induced IkappaBalpha phosphorylation 196309-76-9
Celastrol Inhibits TNF-alpha-induced NF-kappaB activation 34157-83-0
IKK 16 Selective inhibitor of IKK 1186195-62-9
Ro 106-9920 Inhibitor of NF-kappaB activation 62645-28-7
TPCA-1 Potent, selective inhibitor of IKKbeta 507475-17-4

(14) ApexBio Compounds for TNF Gene

Compound Action Cas Number
Bay 11-7821(BAY 11-7082) IKK/NF-κB/TNFα inhibitor 19542-67-7
Bioymifi
Calcitriol TNF-α and IL-1β production inhibitor 32222-06-3
Cepharanthine 481-49-2
Lenalidomide (CC-5013) Antineoplastic agent,inhibits angiogenesis 191732-72-6
Lenalidomide hemihydrate 847871-99-2
Lenalidomide hydrochloride TNF-α secretion inhibitor 1243329-97-6
Magnolol Inhibitor of NO/TNF-α production;antifungal agent 528-43-8
Necrostatin 2 In vitro necroptosis inhibitor 852391-19-6
Necrostatin-1 RIP1 inhibitor 4311-88-0
Pomalidomide (CC-4047) Immunomodulator,antumor/anti-angiogenic 19171-19-8
Roquinimex 84088-42-6
Tempol 2226-96-2
Thalidomide Immunomodulatory agent,sedative drug,angiogenesis inhibitor 50-35-1
genes like me logo Genes that share compounds with TNF: view

Drug Products

Transcripts for TNF Gene

mRNA/cDNA for TNF Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(68) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNF Gene

Tumor necrosis factor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TNF
  • Applied Biological Materials Clones for TNF

Alternative Splicing Database (ASD) splice patterns (SP) for TNF Gene

No ASD Table

Relevant External Links for TNF Gene

GeneLoc Exon Structure for
TNF
ECgene alternative splicing isoforms for
TNF

Expression for TNF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNF Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for TNF Gene

This gene is overexpressed in CD8 Tcells (41.7) and Bone marrow mesenchymal stem cell (27.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNF Gene



Protein tissue co-expression partners for TNF Gene

NURSA nuclear receptor signaling pathways regulating expression of TNF Gene:

TNF

SOURCE GeneReport for Unigene cluster for TNF Gene:

Hs.241570

Evidence on tissue expression from TISSUES for TNF Gene

  • Blood(4.8)
  • Lung(4)
  • Spleen(3.7)
  • Liver(3.5)
  • Heart(3.4)
  • Intestine(3.3)
  • Lymph node(3.3)
  • Nervous system(3.3)
  • Skin(3.2)
  • Muscle(3.1)
  • Bone marrow(2.9)
  • Kidney(2.9)
  • Bone(2.8)
  • Eye(2.4)
  • Pancreas(2.4)
  • Stomach(2.2)
  • Urine(2.1)
  • Adrenal gland(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TNF Gene

Germ Layers:
  • ectoderm
  • endoderm
Systems:
  • digestive
  • nervous
Organs:
Head and neck:
  • brain
  • head
Thorax:
  • esophagus
Abdomen:
  • stomach
genes like me logo Genes that share expression patterns with TNF: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TNF Gene

Orthologs for TNF Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNF 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia TNF 34 35
  • 91.13 (n)
cow
(Bos Taurus)
Mammalia TNF 34 35
  • 84.55 (n)
mouse
(Mus musculus)
Mammalia Tnf 34 16 35
  • 82.9 (n)
rat
(Rattus norvegicus)
Mammalia Tnf 34
  • 82.76 (n)
oppossum
(Monodelphis domestica)
Mammalia TNF 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tnf 34
  • 50.43 (n)
zebrafish
(Danio rerio)
Actinopterygii tnfa 35
  • 26 (a)
ManyToMany
tnfb 35
  • 24 (a)
ManyToMany
Species where no ortholog for TNF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNF Gene

ENSEMBL:
Gene Tree for TNF (if available)
TreeFam:
Gene Tree for TNF (if available)

Paralogs for TNF Gene

Paralogs for TNF Gene

(2) SIMAP similar genes for TNF Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TNF: view

Variants for TNF Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TNF Gene

TNFA_HUMAN-P01375
Genetic variations in TNF are involved in susceptibility to malaria [MIM:611162].
TNFA_HUMAN-P01375
Genetic variations in TNF influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].

Sequence variations from dbSNP and Humsavar for TNF Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs281865419 Pathogenic 31,577,157(+) ACCGC(C/T)GGGCC reference, missense
rs1800629 drug-response 31,575,254(+) GCATG(A/G)GGACG upstream-variant-2KB
rs1000202700 -- 31,574,929(+) CAGTG(A/G)GGTCT upstream-variant-2KB
rs1000808024 -- 31,576,897(+) ACTTG(C/G)AGACA intron-variant
rs1003548402 -- 31,578,312(+) GCGAG(-/A)AATAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TNF Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv462870 CNV loss 19166990
nsv470809 CNV loss 18288195
nsv601941 CNV loss 21841781
nsv830627 CNV loss 17160897

Variation tolerance for TNF Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNF Gene

Human Gene Mutation Database (HGMD)
TNF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNF

Disorders for TNF Gene

MalaCards: The human disease database

(440) MalaCards diseases for TNF Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards