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Aliases for TNC Gene

Aliases for TNC Gene

  • Tenascin C 2 3
  • HXB 3 4 6
  • Glioma-Associated-Extracellular Matrix Antigen 3 4
  • Deafness, Autosomal Dominant 56 2 3
  • Hexabrachion (Tenascin) 2 3
  • Myotendinous Antigen 3 4
  • Neuronectin 3 4
  • GP 150-225 3 4
  • Cytotactin 3 4
  • DFNA56 3 6
  • TN-C 3 4
  • GMEM 3 4
  • TN 3 4
  • JI 3 4
  • Hexabrachion (Tenascin C, Cytotactin) 2
  • Tenascin-C Additional Domain 1 3
  • Tenascin-C Isoform 14/AD1/16 3
  • Hexabrachion 4
  • Tenascin-C 4
  • Tenascin 3
  • 150-225 3
  • GP 3

External Ids for TNC Gene

Previous Symbols for TNC Gene

  • HXB
  • DFNA56

Summaries for TNC Gene

Entrez Gene Summary for TNC Gene

  • This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

GeneCards Summary for TNC Gene

TNC (Tenascin C) is a Protein Coding gene. Diseases associated with TNC include deafness, autosomal dominant 56 and juvenile pilocytic astrocytoma. Among its related pathways are PI3K-Akt signaling pathway and ERK Signaling. GO annotations related to this gene include syndecan binding. An important paralog of this gene is FGA.

UniProtKB/Swiss-Prot for TNC Gene

  • Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6

Gene Wiki entry for TNC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNC Gene

Genomics for TNC Gene

Genomic Location for TNC Gene

Start:
115,019,575 bp from pter
End:
115,118,257 bp from pter
Size:
98,683 bases
Orientation:
Minus strand

Genomic View for TNC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNC Gene

Regulatory Elements for TNC Gene

Proteins for TNC Gene

  • Protein details for TNC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24821-TENA_HUMAN
    Recommended name:
    Tenascin
    Protein Accession:
    P24821
    Secondary Accessions:
    • C9IYT7
    • C9J575
    • C9J6D9
    • C9J848
    • Q14583
    • Q15567
    • Q5T7S3

    Protein attributes for TNC Gene

    Size:
    2201 amino acids
    Molecular mass:
    240853 Da
    Quaternary structure:
    • Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.

    Three dimensional structures from OCA and Proteopedia for TNC Gene

    Alternative splice isoforms for TNC Gene

neXtProt entry for TNC Gene

Proteomics data for TNC Gene at MOPED

Post-translational modifications for TNC Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn38, Asn166, Asn184, Asn327, Asn788, Asn1018, Asn1034, Asn1079, Asn1093, Asn1119, Asn1184, Asn1210, Asn1261, Asn1275, Asn1301, Asn1366, Asn1392, Asn1445, Asn1455, Asn1485, Asn1534, Asn1809, and Asn2162

Other Protein References for TNC Gene

No data available for DME Specific Peptides for TNC Gene

Domains for TNC Gene

Gene Families for TNC Gene

HGNC:
  • FIBC :Fibrinogen C domain containing
  • FN3 :Fibronectin type III domain containing

UniProtKB/Swiss-Prot:

TENA_HUMAN
Domain:
  • Contains 15 EGF-like domains.:
    • P24821
  • Contains 1 fibrinogen C-terminal domain.:
    • P24821
  • Contains 15 fibronectin type-III domains.:
    • P24821
Family:
  • Belongs to the tenascin family.:
    • P24821
genes like me logo Genes that share domains with TNC: view

Function for TNC Gene

Molecular function for TNC Gene

UniProtKB/Swiss-Prot Function: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6
UniProtKB/Swiss-Prot Induction: By TGFB1

Gene Ontology (GO) - Molecular Function for TNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0045545 syndecan binding IDA 8769660
genes like me logo Genes that share ontologies with TNC: view
genes like me logo Genes that share phenotypes with TNC: view

Animal Models for TNC Gene

MGI Knock Outs for TNC:

miRNA for TNC Gene

miRTarBase miRNAs that target TNC

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TNC Gene

Localization for TNC Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNC Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNC Gene COMPARTMENTS Subcellular localization image for TNC gene
Compartment Confidence
extracellular 5
cytoskeleton 3
plasma membrane 3
cytosol 2
nucleus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for TNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix --
GO:0005604 basement membrane IEA --
GO:0005614 interstitial matrix IEA --
GO:0005615 extracellular space IDA 16502470
genes like me logo Genes that share ontologies with TNC: view

Pathways for TNC Gene

genes like me logo Genes that share pathways with TNC: view

Pathways by source for TNC Gene

Gene Ontology (GO) - Biological Process for TNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0007155 cell adhesion IEA --
GO:0007162 negative regulation of cell adhesion IEA --
GO:0007528 neuromuscular junction development IEA --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with TNC: view

Compounds for TNC Gene

(41) Novoseek inferred chemical compound relationships for TNC Gene

Compound -log(P) Hits PubMed IDs
neurocan 74.7 12
chondroitin sulfate 39.3 5
tgf beta1 36.3 3
vegf 27.8 18
matrigel 23.6 1
genes like me logo Genes that share compounds with TNC: view

Transcripts for TNC Gene

Unigene Clusters for TNC Gene

Tenascin C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNC Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ·
SP1: -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: -
SP7:
SP8: -
SP9: - - - - - - - -

ExUns: 18c ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1:
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TNC Gene

GeneLoc Exon Structure for
TNC
ECgene alternative splicing isoforms for
TNC

Expression for TNC Gene

mRNA expression in normal human tissues for TNC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNC Gene

This gene is overexpressed in Artery - Tibial (11.4) and Colon - Sigmoid (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNC Gene

SOURCE GeneReport for Unigene cluster for TNC Gene Hs.143250

genes like me logo Genes that share expressions with TNC: view

Orthologs for TNC Gene

This gene was present in the common ancestor of animals.

Orthologs for TNC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNC 36
  • 99.21 (n)
  • 99.18 (a)
TNC 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNC 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNC 36
  • 87.52 (n)
  • 88.05 (a)
TNC 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnc 36
  • 74.06 (n)
  • 71.98 (a)
Tnc 16
Tnc 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNC 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNC 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnc 36
  • 73.97 (n)
  • 71.65 (a)
chicken
(Gallus gallus)
Aves TNC 36
  • 62.98 (n)
  • 57.8 (a)
TNC 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNC 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24480 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15574 36
tnc 36
  • 58.62 (n)
  • 54.27 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4969 36
zebrafish
(Danio rerio)
Actinopterygii CABZ01048373.1 37
  • 45 (a)
OneToMany
LOC100149028 36
  • 54.7 (n)
  • 47.76 (a)
tenc 36
tnc 37
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30281 38
  • 39 (a)
CG1791 38
  • 40 (a)
BG:DS00180.10 38
  • 31 (a)
CG30280 38
  • 39 (a)
BG:DS00180.14 38
  • 28 (a)
CG5550 38
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToMany
Species with no ortholog for TNC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNC Gene

ENSEMBL:
Gene Tree for TNC (if available)
TreeFam:
Gene Tree for TNC (if available)

Paralogs for TNC Gene

Paralogs for TNC Gene

Pseudogenes.org Pseudogenes for TNC Gene

genes like me logo Genes that share paralogs with TNC: view

Variants for TNC Gene

Sequence variations from dbSNP and Humsavar for TNC Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1511 -- 115,093,835(-) CCAGT(G/T)TACGT intron-variant
rs1513 -- 115,093,851(+) CCAAA(G/T)GTTGC intron-variant
rs13321 - 115,030,304(-) AGGCT(C/G)AGGCG missense, reference
rs769331 -- 115,099,192(+) AAATG(A/G)TTTAT intron-variant
rs881496 -- 115,098,189(-) GAAAT(A/G)ATTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNC Gene

Variant ID Type Subtype PubMed ID
nsv893750 CNV Loss 21882294
nsv7434 OTHER Inversion 18451855
nsv831696 CNV Gain 17160897
nsv519131 CNV Loss 19592680
esv3825 CNV Deletion 18987735
esv2738965 CNV Deletion 23290073
esv21967 CNV Gain 19812545
nsv893768 CNV Gain 21882294
esv2422541 CNV Deletion 19546169
esv2738966 CNV Deletion 23290073
esv2738967 CNV Deletion 23290073
esv1008522 CNV Deletion 20482838
esv1713245 CNV Deletion 17803354
nsv831697 CNV Loss 17160897

Relevant External Links for TNC Gene

HapMap Linkage Disequilibrium report
TNC
Human Gene Mutation Database (HGMD)
TNC

Disorders for TNC Gene

(1) OMIM Diseases for TNC Gene (187380)

UniProtKB/Swiss-Prot

TENA_HUMAN
  • Deafness, autosomal dominant, 56 (DFNA56) [MIM:615629]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with post-lingual onset. {ECO:0000269 PubMed:23936043}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for TNC Gene

(98) Novoseek inferred disease relationships for TNC Gene

Disease -log(P) Hits PubMed IDs
bullous keratopathy 60.4 7
glioblastoma 59 28
distant cancer 58 2
tumors 52 200
glioma 51.1 51

Relevant External Links for TNC

Genetic Association Database (GAD)
TNC
Human Genome Epidemiology (HuGE) Navigator
TNC
genes like me logo Genes that share disorders with TNC: view

Publications for TNC Gene

  1. Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies. (PMID: 1707164) Siri A. … Zardi L. (Nucleic Acids Res. 1991) 2 3 4 23
  2. Human tenascin gene. Structure of the 5'-region, identification, and characterization of the transcription regulatory sequences. (PMID: 7531707) Gherzi R. … Zardi L. (J. Biol. Chem. 1995) 3 4 23
  3. The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats. (PMID: 1704365) Nies D.E. … Stefansson K. (J. Biol. Chem. 1991) 2 3 4
  4. Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss. (PMID: 23936043) Zhao Y. … Wang Q. (PLoS ONE 2013) 2 3 4
  5. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3 49

Products for TNC Gene

  • Addgene plasmids for TNC

Sources for TNC Gene

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