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TNC Gene

protein-coding   GIFtS: 69
GCID: GC09M117782

Tenascin C

(Previous names: hexabrachion (tenascin C, cytotactin), deafness, autosomal...)
(Previous symbols: HXB, DFNA56)
  See TNC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tenascin C1 2     Hexabrachion (Tenascin C, Cytotactin)1
HXB1 2 3 5     150-2252
DFNA561 2 5     GP2
Deafness, Autosomal Dominant 561 2     cytotactin2
Hexabrachion (Tenascin)1 2     neuronectin2
Glioma-Associated-Extracellular Matrix Antigen2 3     tenascin2
Myotendinous Antigen2 3     Tenascin-C Additional Domain 12
GMEM2 3     Tenascin-C Isoform 14/AD1/162
JI2 3     Cytotactin3
TN2 3     Hexabrachion3
TN-C2 3     Neuronectin3
GP 150-2252 3     Tenascin-C3

External Ids:    HGNC: 53181   Entrez Gene: 33712   Ensembl: ENSG000000419827   OMIM: 1873805   UniProtKB: P248213   

Export aliases for TNC gene to outside databases

Previous GC identifers: GC09M108581 GC09M109514 GC09M111236 GC09M113158 GC09M113135 GC09M114862 GC09M116822 GC09M087387


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNC Gene:
This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution.
This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin
type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic
plasticity, and neuronal regeneration. (provided by RefSeq, Jul 2011)

GeneCards Summary for TNC Gene:
TNC (tenascin C) is a protein-coding gene. Diseases associated with TNC include juvenile pilocytic astrocytoma, and deafness, autosomal dominant 56. GO annotations related to this gene include syndecan binding. An important paralog of this gene is TNXB.

UniProtKB/Swiss-Prot: TENA_HUMAN, P24821
Function: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during
development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical
neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3
and alpha-V/beta-6

Gene Wiki entry for TNC (Tenascin C) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNC gene promoter:
         Sp1   AP-1   ATF-2   STAT3   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNC promoter sequence
   Search Chromatin IP Primers for TNC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33   Ensembl cytogenetic band:  9q33.1   HGNC cytogenetic band: 9q33.1

TNC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNC gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M117782:  view genomic region     (about GC identifiers)

Start:
117,782,805 bp from pter      End:
117,880,536 bp from pter
Size:
97,732 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TENA_HUMAN, P24821 (See protein sequence)
Recommended Name: Tenascin precursor  
Size: 2201 amino acids; 240853 Da
Subunit: Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be
stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the
central globule. Interacts with CSPG4
3 PDB 3D structures from and Proteopedia for TNC:
1TEN (3D)        2RB8 (3D)        2RBL (3D)    
Secondary accessions: C9IYT7 C9J575 C9J6D9 C9J848 Q14583 Q15567 Q5T7S3
Alternative splicing: 6 isoforms:  P24821-1   P24821-2   P24821-3   P24821-4   P24821-5   P24821-6   

Explore the universe of human proteins at neXtProt for TNC: NX_P24821

Explore proteomics data for TNC at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn38, Asn166, Asn184, Asn327, Asn788, Asn1018, Asn1034, Asn1079, Asn1093, Asn1119,
                                 Asn1184, Asn1210, Asn1261, Asn1275, Asn1301, Asn1366, Asn1392, Asn1445, Asn1455, Asn1485 (see all 23)
  • Modification sites at PhosphoSitePlus

  • See TNC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002151.2  
    ENSEMBL proteins: 
     ENSP00000265131   ENSP00000339553   ENSP00000411406   ENSP00000443478   ENSP00000442242  
     ENSP00000445380   ENSP00000443469   ENSP00000344400   ENSP00000438152   ENSP00000344555  
     ENSP00000345861  
    Reactome Protein details: P24821

    TNC Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant TNC Protein
    R&D Systems Recombinant & Natural Proteins for TNC (Tenascin C)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TNC
    OriGene Protein Over-expression Lysate for TNC
    OriGene MassSpec for TNC
    OriGene Custom Protein Services for TNC
    GenScript Custom Purified and Recombinant Proteins Services for TNC
    Novus Biologicals TNC Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNC

     
    Search eBioscience for Proteins for TNC 

    TNC Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TNC
    R&D Systems Antibodies for TNC (Tenascin C)
    Cell Signaling Technology (CST) Antibodies for TNC 
    OriGene Antibodies for TNC
    OriGene Custom Antibody Services for TNC
    Novus Biologicals TNC Antibodies
    Abcam antibodies for TNC (Q5T7S3, P24821)
    Cloud-Clone Corp. Antibodies for TNC
    ThermoFisher Antibody for TNC
    LSBio Antibodies in human, mouse, rat for TNC

    TNC Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TNC
    R&D Systems Luminex Assays for TNC (Tenascin C)
    GenScript Custom Assay Services for TNC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TNC
    Cloud-Clone Corp. CLIAs for TNC
    Search eBioscience for ELISAs for TNC 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    FIBC: Fibrinogen C domain containing

    Selected InterPro protein domains (see all 8):
     IPR000742 EG-like_dom
     IPR003961 Fibronectin_type3
     IPR013032 EGF-like_CS
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR002181 Fibrinogen_a/b/g_C_dom

    Graphical View of Domain Structure for InterPro Entry P24821

    ProtoNet protein and cluster: P24821

    3 Blocks protein domains:
    IPB002049 Laminin-type EGF-like domain
    IPB002181 Fibrinogen
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: TENA_HUMAN, P24821
    Similarity: Belongs to the tenascin family
    Similarity: Contains 15 EGF-like domains
    Similarity: Contains 1 fibrinogen C-terminal domain
    Similarity: Contains 15 fibronectin type-III domains


    Find genes that share domains with TNC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TENA_HUMAN, P24821
    Function: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during
    development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical
    neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3
    and alpha-V/beta-6
    Induction: By TGFB1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0045545syndecan binding IPI8769660
         
    Find genes that share ontologies with TNC           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNC:
     Decreased influenza A/WSN/33 r  Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tnc):
     behavior/neurological  hearing/vestibular/ear  homeostasis/metabolism  nervous system  normal 

    Find genes that share phenotypes with TNC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TNC: Tnctm1Msch Tnctm1Ref

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNC

    miRNA
    Products:
        
    miRTarBase miRNAs that target TNC:
    hsa-mir-335-5p (MIRT000666)

    Block miRNA regulation of human, mouse, rat TNC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNC (see all 18):
    hsa-miR-495 hsa-miR-330-5p hsa-miR-548k hsa-miR-218 hsa-miR-29b-1* hsa-miR-511 hsa-miR-9 hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidTNC 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TNC
    Predesigned siRNA for gene silencing in human, mouse, rat TNC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TNC

    Clone
    Products:
         
    OriGene clones in human, mouse for TNC (see all 5)
    OriGene ORF clones in mouse, rat for TNC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNC (NM_002160)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNC
    Addgene plasmids for TNC 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TNC
    ESI BIO PureStem Progenitors for TNC: 
    PureStem 7PEND24, NCr-fac & Meso-prx Progenitor, PureStem 7SMOO32, NCr-fac & Meso Progenitor,
    PureStem MEL2, NCr-fac Progenitor, PureStem SM30, NCr-fac & Meso-latp Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TENA_HUMAN, P24821: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton3
    plasma membrane3
    cytosol2
    nucleus2
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005604basement membrane IEA--
    GO:0005614interstitial matrix IEA--
    GO:0005615extracellular space IDA--

    Find genes that share ontologies with TNC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNC About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    ECM-receptor interaction0.31
    Focal Adhesion0.65
    2Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Phospholipase-C Pathway
    Phospholipase-C Pathway0.56
    PTEN Pathway0.56
    5Non-integrin membrane-ECM interactions
    Non-integrin membrane-ECM interactions0.35
    Syndecan interactions0.00


    Find genes that share SuperPaths with TNC           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNC (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    2 Cell Signaling Technology (CST) Pathways for TNC
        Angiogenesis
    Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for TNC
        Cell adhesion Cell-matrix glycoconjugates

    2 BioSystems Pathways for TNC
        Focal Adhesion
    Syndecan-4-mediated signaling events

    3 Reactome Pathways for TNC
        ECM proteoglycans
    Integrin cell surface interactions
    Syndecan interactions


    4 Kegg Pathways  (Kegg details for TNC):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNC: 
              Notch Signaling Targets in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Atherosclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNC (P248213 ENSP000002651314) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FN1P027513, ENSP000003468394I2D: score=3 STRING: ENSP00000346839
    CNTN1Q128603, ENSP000003256604I2D: score=2 STRING: ENSP00000325660
    PTPRBP234673, ENSP000003349284I2D: score=1 STRING: ENSP00000334928
    EGFRP005333, ENSP000002754934I2D: score=1 STRING: ENSP00000275493
    ITGA5P086483, ENSP000002933794I2D: score=2 STRING: ENSP00000293379
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007162negative regulation of cell adhesion IEA--
    GO:0007528neuromuscular junction development IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0009611response to wounding IEP16891397

    Find genes that share ontologies with TNC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNC (TENA)

    Selected Novoseek inferred chemical compound relationships for TNC gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurocan 74.7 15 9341124 (4), 9182584 (2), 15316653 (2), 20420122 (1) (see all 7)
    chondroitin sulfate 39.3 7 9804349 (2), 8663515 (1), 15700272 (1), 18696101 (1)
    tgf beta1 36.3 3 19561339 (1), 15033492 (1), 19857272 (1)
    vegf 27.8 21 14618612 (5), 11813879 (3), 16388320 (2), 18504437 (1) (see all 11)
    matrigel 23.6 1 10403553 (1)
    procollagen 20.8 3 15187760 (2), 20010126 (1)
    fibrinogen 19.1 15 9182584 (5), 7531705 (4), 8620517 (1), 1709136 (1) (see all 7)
    glycosaminoglycan 17.7 1 9182584 (1)
    heparan sulfate 13.3 1 17901052 (1)
    phorbol 9.65 2 9735343 (1)



    Find genes that share compounds with TNC           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNC gene: 
    NM_002160.3  

    Unigene Cluster for TNC:

    Tenascin C
    Hs.143250  [show with all ESTs]
    Unigene Representative Sequence: NM_002160
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000350763(uc010mvf.3 uc004bjj.4) ENST00000341037 ENST00000423613
    ENST00000537320 ENST00000542877(uc022bmj.1) ENST00000544972 ENST00000460345
    ENST00000498724 ENST00000476680 ENST00000473855 ENST00000481475 ENST00000534839
    ENST00000340094 ENST00000535648 ENST00000346706 ENST00000345230
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TNC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNC (see all 18):
    hsa-miR-495 hsa-miR-330-5p hsa-miR-548k hsa-miR-218 hsa-miR-29b-1* hsa-miR-511 hsa-miR-9 hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidTNC 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TNC
    Predesigned siRNA for gene silencing in human, mouse, rat TNC
    Clone
    Products:
         
    OriGene clones in human, mouse for TNC (see all 5)
    OriGene ORF clones in mouse, rat for TNC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNC (NM_002160)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNC
    Addgene plasmids for TNC 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TNC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNC
      QuantiTect SYBR Green Assays in human, mouse, rat TNC
      QuantiFast Probe-based Assays in human, mouse, rat TNC

    Additional mRNA sequence: 

    AB210038.1 AK024586.1 AK304015.1 BC151843.1 BX641111.1 EU295718.1 GU473235.1 M24630.1 
    M55618.1 M96686.1 X56160.1 X78565.1 

    20 DOTS entries:

    DT.95353163  DT.451498  DT.95266322  DT.40119585  DT.95266324  DT.437379  DT.121172053  DT.75149020 
    DT.95121426  DT.95155027  DT.95266323  DT.97777013  DT.99996612  DT.121622667  DT.95150024  DT.97768638 
    DT.100786509  DT.121172081  DT.92415687  DT.95289677 

    Selected AceView cDNA sequences (see all 389):

    BU631048 F13432 CA412575 BM973568 BM841731 BP365442 BX420552 BQ893588 
    BU683430 BX097798 AI359378 BX504444 BM979442 F10855 AI049690 F13016 
    T77030 F10613 AA328705 CD673665 AA386040 BM720487 X80280 AA375942 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TNC (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ·
    SP1:              -                                                                                                                                             
    SP2:                                                                                                  -     -     -     -     -     -     -     -     -     -   
    SP3:                                                                                                                          -     -     -     -     -     -   
    SP4:                                                                                                  -     -     -     -     -     -     -     -     -     -   
    SP5:                                                                                                  -     -     -     -     -     -     -     -     -     -   

    ExUns: 18c ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
    SP1:                                                                              
    SP2:  -                                                                           
    SP3:  -                                                                           
    SP4:  -                                                                           
    SP5:  -                                                                           


    ECgene alternative splicing isoforms for TNC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCTGTATA
    TNC Expression
    About this image


    TNC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 34) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 21 entries
             Endochondral Preosteoblasts Caudal Endochondral Bones
             Endochondral Facial Bones
             Notch-transfected mesenchymal stromal cells (SB623)
     
     Cartilage (Muscoskeletal System)    fully expand to see all 15 entries
             Articular Cartilage Cells Zeugopod Articular Cartilage
     
     Tendon & Ligament (Muscoskeletal System)    fully expand to see all 4 entries
             Early Tenocyte Cells Limb Tendon Primordia
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
             Autopod
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
             Detroit 551
    TNC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.143250
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNC: 
              Notch Signaling Targets in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Atherosclerosis in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for TNC gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnc1 , 5 tenascin C1, 5 74.06(n)1
    71.98(a)1
      4 (34.06 cM)5
    219231  NM_011607.31  NP_035737.21 
     639597855 
    chicken
    (Gallus gallus)
    Aves TNC1 tenascin C 62.98(n)
    57.8(a)
      396440  NM_205456.2  NP_990787.2 
    lizard
    (Anolis carolinensis)
    Reptilia TNC6
    tenascin C
    73(a)
    1 ↔ 1
    GL343494.1(173381-222979)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.244802 Xenopus laevis transcribed sequence with weak similarity more 82(n)    BJ088991.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tenc2 tenascin C 73.56(n)   30037  X89203.1 


    ENSEMBL Gene Tree for TNC (if available)
    TreeFam Gene Tree for TNC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNC gene
    TNXB2  ANGPTL32  TNR2  FGA2  TNN2  ANGPTL42  ANGPTL52  FN12  
    17 SIMAP similar genes for TNC using alignment to 8 protein entries:     TENA_HUMAN (see all proteins):
    TNC variant protein    FCN3    FCN2    FIBCD1    FCN1    MFAP4
    ANGPT1    ANGPTL2    ANGPTL7    FGL1    LFIRE1    XB
    TNXA    ANGPTL4    HMGA2/WIF1 fusion    TNXB    TENM4

    Find genes that share paralogs with TNC           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TNC
    PGOHUM00000260485


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNC (see all 2473)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1431588371,2
    Cuntested1117858730(+) ACACGA/G/TATAAA 2 I syn11NA 4552
    rs3768220381,2
    C--87416037(+) TTTTT-/T/TT  
            
    GTGTC
    1 -- int11NA 2
    rs1404121081,2
    C--87434299(+) CTGTT-/TTTG  
            
    TTTCT
    1 -- int10--------
    rs341930281,2
    C--87444186(+) ATTCG-/CCCGCC 1 -- int10--------
    rs761943931,2
    C--87454413(+) TAGGGG/ATGTGT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1117641671,2
    C--87454419(+) TAGGG-/GTGTGTGTGTG
    TGTGTGTGTGTGT
    GTGTG
    1 -- int11Minor allele frequency- GTGTGTGTGTGTGTGTGTGTGTGT:0.50CSA 2
    rs573277151,2
    C--87454427(+) TGTGT-/GTGTGTGTGTG
    TGTGTGTGTGTGT
    ATTTC
    1 -- int10--------
    rs1115939221,2
    C--87454442(+) GTGTGG/TGTGTG 1 -- int10--------
    rs1490727351,2
    C--87473762(+) GATGA-/TTTTTT 1 -- int10--------
    rs615774681,2
    C--117782492(+) TTTTTT/-CTGTA 1 -- ut311Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for TNC (117782805 - 117880536 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TNC (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738967CNV Deletion23290073
    esv1008522CNV Deletion20482838
    esv1713245CNV Deletion17803354
    esv3825CNV Deletion18987735
    esv2738965CNV Deletion23290073
    esv2422541CNV Deletion19546169
    esv2738966CNV Deletion23290073
    nsv831697CNV Loss17160897
    nsv893750CNV Loss21882294
    nsv519131CNV Loss19592680

    Human Gene Mutation Database (HGMD): TNC
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing TNC:
    Glioma
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing TNC
    DNA2.0 Custom Variant and Variant Library Synthesis for TNC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 187380   
    OMIM disorders: 615629  
    Selected diseases for TNC (see all 21):    
    About MalaCards
    juvenile pilocytic astrocytoma    deafness, autosomal dominant 56    acute myocarditis    bullous keratopathy
    cryptogenic organizing pneumonia    keratopathy    desquamative interstitial pneumonia    myocarditis
    tendinitis    sialadenitis    astrocytoma    aortic valve disease
    pilocytic astrocytoma    usual interstitial pneumonia    retinoschisis    leukoplakia
    hypertrophic scars    pneumonia    dentinogenesis imperfecta    pheochromocytoma

    3 diseases from the University of Copenhagen DISEASES database for TNC:
    Malignant glioma     Bullous keratopathy     Carcinoma

    Find genes that share disorders with TNC           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TNC gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bullous keratopathy 60.4 9 9620072 (2), 9850274 (2), 11668187 (1), 14550395 (1) (see all 5)
    glioblastoma 59 36 19459858 (6), 7684178 (4), 10658911 (2), 11313993 (1) (see all 19)
    distant cancer 58 2 9836485 (1), 11948127 (1)
    tumors 52 321 11118570 (8), 14635078 (8), 11590140 (5), 15603851 (5) (see all 99)
    glioma 51.1 61 11920587 (7), 11980665 (6), 9512505 (4), 16292494 (4) (see all 21)
    anaplastic astrocytoma 47.8 10 7684178 (4), 12437133 (2), 11118570 (1), 14635078 (1) (see all 6)
    carcinoma 47.2 74 7559800 (4), 1726610 (4), 9219848 (3), 14598568 (2) (see all 37)
    astrocytoma 47 45 17983425 (5), 8548761 (5), 9144580 (5), 10936787 (4) (see all 13)
    glioblastoma multiforme 45.7 11 7531617 (2), 11980665 (1), 10933231 (1), 16388320 (1) (see all 6)
    juvenile pilocytic astrocytoma 44.4 2 7531617 (2)

    Genetic Association Database (GAD): TNC
    Human Genome Epidemiology (HuGE) Navigator: TNC (23 documents)

    Export disorders for TNC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNC gene, integrated from 10 sources (see all 609):
    (articles sorted by number of sources associating them with TNC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies. (PubMed id 1707164)1, 2, 3, 9 Siri A.... Zardi L. (Nucleic Acids Res. 1991)
    2. The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats. (PubMed id 1704365)1, 2, 3 Nies D.E.... Stefansson K. (J. Biol. Chem. 1991)
    3. Investigation of the Sp1-binding site polymorphism within the COL1A1 gene in participants with Achilles tendon injuries and controls. (PubMed id 18353721)1, 4, 9 Posthumus M....Collins M. (J Sci Med Sport 2009)
    4. Human tenascin gene. Structure of the 5'-region, identification, and characterization of the transcription regulatory sequences. (PubMed id 7531707)1, 2, 9 Gherzi R.... Zardi L. (J. Biol. Chem. 1995)
    5. Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss. (PubMed id 23936043)1, 3 Zhao Y....Wang Q. (PLoS ONE 2013)
    6. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (Carcinogenesis 2012)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    9. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (Gastroenterology 2010)
    10. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PubMed id 20583170)1, 4 Letra A....Vieira A.R. (Am. J. Med. Genet. A 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3371 HGNC: 5318 AceView: TNC Ensembl:ENSG00000041982 euGenes: HUgn3371
    ECgene: TNC Kegg: 3371 H-InvDB: TNC

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNC gene:
    Search GeneIP for patents involving TNC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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