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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TNC Gene

protein-coding GIFtS: 70
GCID: GC09M117782

tenascin C

(Previous names: hexabrachion (tenascin C, cytotactin) )
(Previous symbol: HXB)

Explore 136 diseases affiliated with
TNC via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tenascin C¹ ²		150-225²
HXB¹ ² ³ ⁵		GP²
TN¹ ² ³		Cytotactin³
Glioma-Associated-Extracellular Matrix Antigen² ³		Hexabrachion (Tenascin)²
Myotendinous Antigen² ³		Neuronectin³
GMEM² ³		Tenascin¹
JI² ³		Tenascin-C Isoform 14/AD1/16²
TN-C² ³		Cytotactin³
GP 150-225² ³		Hexabrachion³
MGC167029¹		Neuronectin³
Hexabrachion (Tenascin C, Cytotactin)¹		Tenascin-C³

External Ids:	HGNC: 5318¹	Entrez Gene: 3371²	Ensembl: ENSG00000041982⁷	OMIM: 187380⁵	UniProtKB: P24821³

Export aliases for TNC gene to outside databases

Previous GC identifers: GC09M108581 GC09M109514 GC09M111236 GC09M113158 GC09M113135 GC09M114862 GC09M116822 GC09M087387

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNC:

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This

protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III

domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity,

and neuronal regeneration. (provided by RefSeq, Jul 2011)

UniProtKB/Swiss-Prot: TENA_HUMAN, P24821

Function: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development,

synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a

monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6

Gene Wiki entry for TNC (Tenascin C)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNC gene promoter:
Sp1 AP-1 ATF-2 STAT3 c-Jun NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNC promoter sequence

Search SABiosciences Chromatin IP Primers for TNC

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33 Ensembl cytogenetic band: 9q33.1 HGNC cytogenetic band: 9q32-q34

TNC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNC gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M117782: view genomic region (about GC identifiers)

Start:	117,782,805 bp from pter	End:	117,880,536 bp from pter
Size:	97,732 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TENA_HUMAN, P24821 (See protein sequence)

Recommended Name: Tenascin precursor

Size: 2201 amino acids; 240853 Da

Subunit: Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be

stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central

globule. Interacts with CSPG4

Subcellular location: Secreted, extracellular space, extracellular matrix

3 PDB 3D structures from and Proteopedia for TNC:

1TEN (3D)

2RB8 (3D)

2RBL (3D)

Secondary accessions: C9IYT7 C9J575 C9J6D9 C9J848 Q14583 Q15567 Q5T7S3

Alternative splicing: 6 isoforms: P24821-1 P24821-2 P24821-3 P24821-4 P24821-5 P24821-6

Explore the universe of human proteins at neXtProt for TNC: NX_P24821

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P24821

TNC Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002151.2

ENSEMBL proteins:

ENSP00000265131 ENSP00000339553 ENSP00000411406 ENSP00000443478 ENSP00000442242

ENSP00000445380 ENSP00000443469 ENSP00000344400 ENSP00000438152 ENSP00000344555

ENSP00000345861

Reactome Protein details: P24821
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant TNC Protein
	R&D Systems Recombinant & Natural Proteins for TNC (Tenascin C)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: TNC OriGene Protein Over-expression Lysate: TNC OriGene Custom Protein Services for TNC
	GenScript Custom Purified and Recombinant Proteins Services for TNC
	Novus Biologicals TNC Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TNC

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005604	basement membrane	IEA	--
GO:0005614	interstitial matrix	IEA	--
GO:0005615	extracellular space	IDA	--
GO:0031012	colocalizes with extracellular matrix	ISS	--

TNC for ontologies About GeneDecksing

TNC Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TNC
	R&D Systems Antibodies for TNC (Tenascin C)
	Cell Signaling Technology (CST) Antibodies for TNC
	OriGene Antibodies (see all 2): TNC OriGene Custom Antibody Services for TNC
	GenScript Custom Superior Antibodies Services for TNC
	Novus Biologicals TNC Antibodies
	Abcam antibodies for TNC
	Uscn Antibodies for TNC
	ThermoFisher Antibodies for TNC

Assay Products for TNC:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TNC
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TNC

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNC for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR000742 EG-like_dom

IPR003961 Fibronectin_type3

IPR013032 EGF-like_CS

IPR014715 Fibrinogen_a/b/g_C_2

IPR002181 Fibrinogen_a/b/g_C_dom

Graphical View of Domain Structure for InterPro Entry P24821

ProtoNet protein and cluster: P24821

3 Blocks protein families:

IPB002049 Laminin-type EGF-like domain

IPB002181 Fibrinogen

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: TENA_HUMAN, P24821

Similarity: Belongs to the tenascin family

Similarity: Contains 15 EGF-like domains

Similarity: Contains 1 fibrinogen C-terminal domain

Similarity: Contains 15 fibronectin type-III domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TENA_HUMAN, P24821

Function: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development,

synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a

monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6

Induction: By TGFB1

miRNA Products:		miRTarBase miRNAs that target TNC: hsa-mir-335 (MIRT000666)

		OriGene 3'-UTR Clone: TNC Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNC
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TNC (see all 18):
		hsa-miR-495 hsa-miR-330-5p hsa-miR-548k hsa-miR-218 hsa-miR-29b-1* hsa-miR-511 hsa-miR-9 hsa-miR-326

		SwitchGear 3'UTR luciferase reporter plasmid: TNC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNC (see all 7) OriGene shRNA RFP: TNC OriGene siRNA: TNC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNC

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TNC

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNC (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNC OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TNC (NM_002160)
		Sino Biological Human cDNA Clone for TNC
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNC

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TNC
		LifeMap BioReagents: cell lines associated with TNC: PureStem 7PEND24, NCr-fac & Meso-prx Progenitor, PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem MEL2, NCr-fac Progenitor, PureStem SM30, NCr-fac & Meso-latp Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNC

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IEA	--
GO:0005488	binding	--	--
GO:0045545	syndecan binding	IPI	8769660

TNC for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for TNC:

Decreased influenza A/WSN/33 r

Increased cell death HMECs cel

Animal Models:
Mouse knock-outs for TNC: Tnc^tm1Msch Tnc^tm1Ref
5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tnc):

behavior/neurological

hearing/vestibular/ear

homeostasis/metabolism

nervous system

normal

TNC for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56	Inhibition of Angiogenesis by TSP1	0.37

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Cell adhesion_Cell-matrix glycoconjugates

Cell adhesion_Cell-matrix glycoconjugates

1.00

Cell adhesion Cell-matrix glycoconjugates

0.97

PTEN Pathway

PTEN Pathway

1.00

Phospholipase-C Pathway

0.56

ECM-receptor interaction

ECM-receptor interaction

1.00

Integrin cell surface interactions

0.32

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for TNC

	Cell adhesion Cell-matrix glycoconjugates
	Selected targets of Oct-3/4
	Metalloproteases in connective tissue degradation

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNC (see all 13)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway

2 Cell Signaling Technology (CST) Pathways for TNC

	Angiogenesis
	Neuroscience

1 GeneGo (Thomson Reuters) Pathway for TNC

Cell adhesion Cell-matrix glycoconjugates

2 BioSystems Pathways for TNC

	Focal Adhesion
	Syndecan-4-mediated signaling events

2 Reactome Pathways for TNC

	Integrin cell surface interactions
	Signal Transduction

2 Kegg Pathways (Kegg details for TNC):

	Focal adhesion
	ECM-receptor interaction

TNC for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TNC

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/34 Interacting proteins for TNC (P24821³ ENSP00000265131⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 34)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FN1	P02751³, ENSP00000346839⁴	I2D: score=3 STRING: ENSP00000346839
CNTN1	Q12860³, ENSP00000325660⁴	I2D: score=2 STRING: ENSP00000325660
PTPRB	P23467³, ENSP00000334928⁴	I2D: score=1 STRING: ENSP00000334928
EGFR	P00533³, ENSP00000275493⁴	I2D: score=1 STRING: ENSP00000275493
ITGA5	P08648³, ENSP00000293379⁴	I2D: score=2 STRING: ENSP00000293379

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007528	neuromuscular junction development	IEA	--
GO:0008284	positive regulation of cell proliferation	IEA	--
GO:0009611	response to wounding	IEP	16891397

TNC for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TNC for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNC
10/41 Novoseek chemical compound relationships for TNC gene (see all 41) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
neurocan	74.7	15	9341124 (4), 9182584 (2), 15316653 (2), 20420122 (1) (see all 7)
chondroitin sulfate	39.3	7	9804349 (2), 8663515 (1), 15700272 (1), 18696101 (1)
tgf beta1	36.3	3	19561339 (1), 15033492 (1), 19857272 (1)
vegf	27.8	21	14618612 (5), 11813879 (3), 16388320 (2), 18504437 (1) (see all 11)
matrigel	23.6	1	10403553 (1)
procollagen	20.8	3	15187760 (2), 20010126 (1)
fibrinogen	19.1	15	9182584 (5), 7531705 (4), 8620517 (1), 1709136 (1) (see all 7)
glycosaminoglycan	17.7	1	9182584 (1)
heparan sulfate	13.3	1	17901052 (1)
phorbol	9.65	2	9735343 (1)

Search CenterWatch for drugs/clinical trials and news about TNC / TENA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNC gene:

NM_002160.3

Unigene Clusters for TNC:

Tenascin C

Hs.143250 [show with all ESTs], Hs.734766 [show with all ESTs]

Unigene Representative Sequences: NM_002160, BQ880861

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000350763(uc010mvf.3 uc004bjj.4) ENST00000341037 ENST00000423613

ENST00000537320 ENST00000542877(uc022bmj.1) ENST00000544972 ENST00000460345

ENST00000498724 ENST00000476680 ENST00000473855 ENST00000481475 ENST00000534839

ENST00000340094 ENST00000535648 ENST00000346706 ENST00000345230

miRNA Products:		OriGene 3'-UTR Clone: TNC Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNC
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TNC (see all 18):
		hsa-miR-495 hsa-miR-330-5p hsa-miR-548k hsa-miR-218 hsa-miR-29b-1* hsa-miR-511 hsa-miR-9 hsa-miR-326

		SwitchGear 3'UTR luciferase reporter plasmid: TNC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNC (see all 7) OriGene shRNA RFP: TNC OriGene siRNA: TNC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNC

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNC (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNC OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TNC (NM_002160)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNC

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNC Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TNC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNC

Additional cDNA sequence: X80280.1

22 DOTS entries:

DT.95353163 DT.451498 DT.95266322 DT.40119585 DT.95266324 DT.437379 DT.121172053 DT.75149020

DT.95121426 DT.95155027 DT.95266323 DT.97777013 DT.99996612 DT.121172015 DT.121622667 DT.91720756

DT.95150024 DT.97768638 DT.100786509 DT.121172081 DT.92415687 DT.95289677

24/389 AceView cDNA sequences (see all 389):

F13432 BX097798 BG984915 BQ893588 BE275952 BF838552 AW849271 BM841731

BP365442 F13016 CD673665 BG676251 BU631048 BX504444 AA375942 BM720487

AA386040 X80280 AA968750 BU683430 AI049690 AU279566 BX420552 F10855

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TNC (see all 9) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^	17	^	18a	·	18b	·
SP1:					-
SP2:																																	-		-		-		-		-		-		-		-		-		-
SP3:																																									-		-		-		-		-		-
SP4:																																	-		-		-		-		-		-		-		-		-		-
SP5:																																	-		-		-		-		-		-		-		-		-		-

ExUns:	18c	^	19a	·	19b	^	20	^	21	^	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29
SP1:
SP2:	-
SP3:	-
SP4:	-
SP5:	-

ECgene alternative splicing isoforms for TNC

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCTGTATA

About this image

TNC expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/52 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 52)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Autopod Epiphyseal End

Prechondrocytes

Selective marker (cell-identifying gene)

Bone, Cartilage

Bone

Caudal Endochondral Bones

Endochondral Preosteoblasts

Bone

Endochondral Facial Bones

Endochondral Preosteoblasts

Bone

Membranous Facial Bones

Intramembranous Osteoblasts

Bone

Membranous Facial Bones

Intramembranous Preosteoblasts

Bone

Rostral Endochondral Facial Bones

Endochondral Preosteoblasts

Bone

Rostral Skull Membranous Bones

Intramembranous Osteoblasts

Bone

Rostral Skull Membranous Bones

Intramembranous Preosteoblasts

Bone

Stylopod Epiphyseal End

Prechondrocytes

Bone, Cartilage

Bone

Zeugopod Epiphyseal End

Prechondrocytes

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/16 LifeMap Cells (see all 16)

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

See TNC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNC

SOURCE GeneReport for Unigene clusters: Hs.143250 Hs.734766

SABiosciences Expression via Pathway-Focused PCR Arrays including TNC:

Notch Signaling Targets in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Atherosclerosis in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TNC gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TNC⁶ TNXB⁶	Uncharacterized protein	72(a) 13(a)	1 ↔ 1 possible ortholog	17(3036348-3102126) 16(19936-27906)
lizard (Anolis carolinensis)	Reptilia	TNC⁶	--	73(a)	1 ↔ 1	GL343494.1(175680-222867)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24480²	Xenopus laevis transcribed sequence with weak similarity more	82(n)		BJ088991.1
zebrafish (Danio rerio)	Actinopterygii	tenc²	tenascin C	73.56(n)		30037 X89203.1

ENSEMBL Gene Tree for TNC (if available)
TreeFam Gene Tree for TNC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TNC gene

TNR² FIBCD1² FCN3² FCN1² FCN2² TNXB² TNN² MFAP4²

FN1² ANGPTL5²

18/19 SIMAP similar genes for TNC using alignment to 8 protein entries: TENA_HUMAN (see all proteins) (see all similar genes):

TNC variant protein FCN3 FCN2 FIBCD1 FCN1 MFAP4

ANGPT1 ANGPTL2 ANGPTL7 FGL1 LFIRE1 XB

TNXA TNR ANGPTL4 HMGA2/WIF1 fusion TENM4 FGB

TNC for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for TNC
PGOHUM00000260485

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143158837^1,2	C	other	91308325(+)	`ACACGA/G/TATAAA`	3	I	syn¹		1		NA	4552
rs200779563^1,2	C	--	87386074(+)	`AGGCCA/TATCAG`	1	--	ds500¹		0	--	--	--	--
rs73551051^1,2	C,	--	87386387(+)	`GGATTG/ATAGAA`	1	--	ds500¹		2		WA	120
rs80085239^1,2	C,F,	--	87386460(+)	`CACAGC/TACACA`	1	--	ds500¹		3		WA NA EA	358
rs58326480^1,2	F,	--	87386470(+)	`ATTTCC/TCCAAA`	1	--	ds500¹		1		WA	118
rs1055758^1,2	C	--	87386605(-)	`GACTGG/TGGTTC`	1	--	ut3¹		2		MN NA	186
rs77310659^1,2		--	87387742(+)	`AATAAC/TGACAA`	1	--	ut3¹		0	--	--	--	--
rs1061531^1,2	C	--	87388007(-)	`TGAGAA/GTCAAA`	1	--	ut3¹		0	--	--	--	--
rs1061512^1,2	C	--	87388118(-)	`AAATTC/GCAGGG`	1	--	ut3¹ ese³		3		MN NA	188
rs80168712^1,2	C,F,	--	87389270(+)	`TATGGT/CAGTCC`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for TNC (117782805 - 117880536 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for TNC
3 CNVs: 100764 43432 70784
3 Indels: 41202 70785 29043
Human Gene Mutation Database (HGMD): TNC

SABiosciences Cancer Mutation PCR Assays

2 SABiosciences qBiomarker Copy Number PCR Arrays containing TNC:

Glioma

Oncogenes & Tumor Suppressor Genes 384HC

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNC

DNA2.0 Custom Variant and Variant Library Synthesis for TNC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TNC for disorders           About GeneDecksing

OMIM gene information: 187380    OMIM disorders: --

20/136 diseases for TNC (see all 136):    About MalaCards

desquamative interstitial pneumonia juvenile pilocytic astrocytoma pilocytic astrocytoma ehlers-danlos syndrome

primitive neuroectodermal tumor cleft lip/palate bullous keratopathy usual interstitial pneumonia

carpal tunnel syndrome aortic valve stenosis dentinogenesis imperfecta myocardial infarction

abdominal aortic aneurysm osteogenesis imperfecta acute myocardial infarction cleft lip

malignant pleural mesothelioma clear cell renal cell carcinoma actinic keratosis proliferative diabetic retinopathy

3 diseases from the University of Copenhagen DISEASES database for TNC:

Malignant glioma Bullous keratopathy Carcinoma

10/98 Novoseek disease relationships for TNC gene (see all 98) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bullous keratopathy	60.4	9	9620072 (2), 9850274 (2), 11668187 (1), 14550395 (1) (see all 5)
glioblastoma	59	36	19459858 (6), 7684178 (4), 10658911 (2), 11313993 (1) (see all 19)
distant cancer	58	2	9836485 (1), 11948127 (1)
tumors	52	321	11118570 (8), 14635078 (8), 11590140 (5), 15603851 (5) (see all 99)
glioma	51.1	61	11920587 (7), 11980665 (6), 9512505 (4), 16292494 (4) (see all 21)
anaplastic astrocytoma	47.8	10	7684178 (4), 12437133 (2), 11118570 (1), 14635078 (1) (see all 6)
carcinoma	47.2	74	7559800 (4), 1726610 (4), 9219848 (3), 14598568 (2) (see all 37)
astrocytoma	47	45	17983425 (5), 8548761 (5), 9144580 (5), 10936787 (4) (see all 13)
glioblastoma multiforme	45.7	11	7531617 (2), 11980665 (1), 10933231 (1), 16388320 (1) (see all 6)
juvenile pilocytic astrocytoma	44.4	2	7531617 (2)

Genetic Association Database (GAD): TNC
Human Genome Epidemiology (HuGE) Navigator: TNC (23 documents)

Export disorders for TNC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TNC gene, integrated from 9 sources (see all 591):
(articles sorted by number of sources associating them with TNC)

Utopia: connect your pdf to the dynamic
world of online information

Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies. (PubMed id 1707164)^{1, 2, 3, 9} Siri A....Zardi L. (1991)
The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats. (PubMed id 1704365)^{1, 2, 3} Nies D.E.... Stefansson K. (1991)
Human tenascin gene. Structure of the 5'-region, identification, and characterization of the transcription regulatory sequences. (PubMed id 7531707)^{1, 2, 9} Gherzi R.... Zardi L. (1995)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
The guanine-thymine dinucleotide repeat polymorphism within the tenascin-C gene is associated with achilles tendon injuries. (PubMed id 15983124)^{1, 4} Mokone G.G....Collins M. (2005)
Coding SNP in tenascin-C Fn-III-D domain associates w ith adult asthma. (PubMed id 16115819)^{1, 4} Matsuda A....Shirakawa T. (2005)
Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules. (PubMed id 8824254)^{1, 2} Burg M.A.... Stallcup W.B. (1996)
Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes. (PubMed id 7524681)^{1, 2} Glumoff V.... Vuorio E. (1994)
Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein. (PubMed id 1279805)^{1, 2} Leahy D.J.... Erickson H.P. (1992)
Structure of the human hexabrachion (tenascin) gene. (PubMed id 1719530)^{1, 2} Gulcher J.R.... Stefansson K. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3371	HGNC: 5318	AceView: TNC	Ensembl:ENSG00000041982	euGenes: HUgn3371
ECgene: TNC	Kegg: 3371	H-InvDB: TNC

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TNC	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNC	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TNC gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TNC gene:
Search GeneIP for patents involving TNC

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Cell Lines associated with TNC: PureStem 7PEND24, NCr-fac & Meso-prx Progenitor,
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TNC Gene

tenascin C

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TNC (Gene Symbol)
Tenascin C
HXB
TN
Glioma-Associated-Extracellular Matrix Antigen
Myotendinous Antigen
GMEM
JI
TN-C
GP 150-225
MGC167029
Hexabrachion (Tenascin C, Cytotactin)
150-225
GP
Cytotactin
Hexabrachion (Tenascin)
Neuronectin
Tenascin
Tenascin-C Isoform 14/AD1/16
Cytotactin
Hexabrachion
Neuronectin
Tenascin-C

Scars Hypertrophic
TONGUE CARCINOMA
Acute myocardial infarction
Sclerosis
dysplasia
Anaplastic Astrocytoma
Vitreoretinopathy Proliferative
Skin Diseases
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Breast Cancer
Neovascularization
Edema
NSCLC
Keratoconus
Asthma
Adenocarcinoma
THYROID CARCINOMA MEDULLARY
Cancer
Hypertension Pulmonary
premalignant
Colorectal Carcinoma
Lymphoma
mammary tumor
Heart Defects Congenital
Leukoplakia
Pathological Processes
RENAL DISEASE
Nasal Polyps
Fibroma
Multiple Sclerosis
Inflammation
Oral Cancer
primitive neuroectodermal tumor PNET
Hypertrophy
ENDOMETRIAL CARCINOMA
Desquamative interstitial pneumonia
Tumors
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Pheochromocytoma
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Glioblastoma
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FIBROSIS IDIOPATHIC PULMONARY
distant cancer
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BREAST CARCINOMA
Brain Tumors
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bladder cancer
Pulmonary Fibrosis
Hyperplasia
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atherosclerotic plaque
Tendinitis
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INFARCT
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PROSTATE CARCINOMA
Neurofibroma
Adenoma Pleomorphic
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Carcinoma Renal Cell
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Cancer Lung
Acute myocarditis
Myocardial Infarction
Meningioma
Scar
Adenoma
benign prostatic hyperplasia
Keloid
Bleeding
Prostatic Intraepithelial Neoplasia
mesothelioma
solid tumor
Lung diseases
Carcinoma Squamous Cell
Colorectal Tumors
SKIN LESION
Bullous keratopathy
Juvenile Pilocytic Astrocytoma
neoplastic disease
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stromal tumors
Carcinoma Merkel Cell
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Neoplastic Processes
Pilocytic Astrocytoma

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TNC Gene

tenascin C

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