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Aliases for TNC Gene

Aliases for TNC Gene

  • Tenascin C 2 3 5
  • Glioma-Associated-Extracellular Matrix Antigen 3 4
  • Deafness, Autosomal Dominant 56 2 3
  • Hexabrachion (Tenascin) 2 3
  • Myotendinous Antigen 3 4
  • Neuronectin 3 4
  • GP 150-225 3 4
  • Cytotactin 3 4
  • GMEM 3 4
  • TN-C 3 4
  • HXB 3 4
  • TN 3 4
  • JI 3 4
  • Hexabrachion (Tenascin C, Cytotactin) 2
  • Tenascin-C Additional Domain 1 3
  • Tenascin-C Isoform 14/AD1/16 3
  • Hexabrachion 4
  • Tenascin-C 4
  • Tenascin 3
  • 150-225 3
  • DFNA56 3
  • GP 3

External Ids for TNC Gene

Previous HGNC Symbols for TNC Gene

  • HXB
  • DFNA56

Previous GeneCards Identifiers for TNC Gene

  • GC09M108581
  • GC09M109514
  • GC09M111236
  • GC09M113158
  • GC09M113135
  • GC09M114862
  • GC09M116822
  • GC09M117782
  • GC09M087387

Summaries for TNC Gene

Entrez Gene Summary for TNC Gene

  • This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

GeneCards Summary for TNC Gene

TNC (Tenascin C) is a Protein Coding gene. Diseases associated with TNC include Deafness, Autosomal Dominant 56 and Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna. Among its related pathways are ECM proteoglycans and Cell adhesion_Cell-matrix glycoconjugates. GO annotations related to this gene include syndecan binding. An important paralog of this gene is TNR.

UniProtKB/Swiss-Prot for TNC Gene

  • Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).

Gene Wiki entry for TNC Gene

Additional gene information for TNC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNC Gene

Genomics for TNC Gene

Regulatory Elements for TNC Gene

Enhancers for TNC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H115114 1.1 ENCODE dbSUPER 14 +1.2 1218 5 KLF17 FEZF1 RAD21 ZEB1 GLIS2 ZNF366 FOS EGR2 CEBPB REST TNC DEC1
GH09H115261 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -144.6 -144563 3 SCRT1 RFX1 NFIB SIN3A FEZF1 NR3C1 ZNF843 FOXA1 JUND GATA3 TNC DEC1 LOC105376233 LOC105376232
GH09H115105 1 ENCODE dbSUPER 15 +11.6 11554 1 FOXA2 MAX CEBPG ZBTB40 RAD21 YY1 ZNF316 POLR2A MAFK GATAD2A TNC DEC1 GC09M115052
GH09H115202 1.3 FANTOM5 Ensembl ENCODE 11.4 -86.9 -86878 5 CTCF PKNOX1 JUN EBF1 BATF RAD21 POLR2A EED FOS ZNF600 DEC1 TNC TNFSF15 LOC105376233 LOC101928748
GH09H115034 1.4 Ensembl ENCODE dbSUPER 10 +82.3 82310 3 TBL1XR1 RB1 BMI1 BATF ZNF766 ETV6 ATF7 RUNX3 CREM IKZF2 TNC GC09M115052 TNFSF8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNC on UCSC Golden Path with GeneCards custom track

Promoters for TNC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000240389 -143 401 FEZF1 ZEB1 GLIS2 FOS EGR2 TSHZ1 ZNF398 ZNF843 ZFP69B ZNF341
ENSR00000337502 357 201 ZFHX2 POLR2A ZNF341 ZBTB26 EGR2

Genomic Location for TNC Gene

Chromosome:
9
Start:
115,019,575 bp from pter
End:
115,118,257 bp from pter
Size:
98,683 bases
Orientation:
Minus strand

Genomic View for TNC Gene

Genes around TNC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNC Gene

Proteins for TNC Gene

  • Protein details for TNC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24821-TENA_HUMAN
    Recommended name:
    Tenascin
    Protein Accession:
    P24821
    Secondary Accessions:
    • C9IYT7
    • C9J575
    • C9J6D9
    • C9J848
    • Q14583
    • Q15567
    • Q5T7S3

    Protein attributes for TNC Gene

    Size:
    2201 amino acids
    Molecular mass:
    240853 Da
    Quaternary structure:
    • Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.

    Three dimensional structures from OCA and Proteopedia for TNC Gene

    Alternative splice isoforms for TNC Gene

neXtProt entry for TNC Gene

Post-translational modifications for TNC Gene

  • Glycosylation at posLast=3838, Asn166, posLast=184184, Asn327, posLast=788788, posLast=10181018, posLast=10341034, posLast=10791079, posLast=10931093, posLast=11191119, Asn1184, Asn1210, Asn1261, Asn1275, posLast=13011301, posLast=13661366, Asn1392, posLast=14451445, Asn1455, Asn1485, Asn1534, posLast=18091809, and posLast=21622162
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TNC (TNC)

No data available for DME Specific Peptides for TNC Gene

Domains & Families for TNC Gene

Gene Families for TNC Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for TNC Gene

Graphical View of Domain Structure for InterPro Entry

P24821

UniProtKB/Swiss-Prot:

TENA_HUMAN :
  • Belongs to the tenascin family.
Family:
  • Belongs to the tenascin family.
genes like me logo Genes that share domains with TNC: view

Function for TNC Gene

Molecular function for TNC Gene

UniProtKB/Swiss-Prot Function:
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).
UniProtKB/Swiss-Prot Induction:
By TGFB1.

Phenotypes From GWAS Catalog for TNC Gene

Gene Ontology (GO) - Molecular Function for TNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045545 syndecan binding IDA 8769660
genes like me logo Genes that share ontologies with TNC: view
genes like me logo Genes that share phenotypes with TNC: view

Human Phenotype Ontology for TNC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TNC Gene

MGI Knock Outs for TNC:

Animal Model Products

CRISPR Products

miRNA for TNC Gene

miRTarBase miRNAs that target TNC

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TNC
  • Applied Biological Materials Clones for TNC
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNC Gene

Localization for TNC Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNC Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNC gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 3
nucleus 2
cytosol 2
lysosome 1

Gene Ontology (GO) - Cellular Components for TNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005604 basement membrane IEA --
GO:0005614 interstitial matrix IEA --
GO:0005615 extracellular space IDA 16502470
genes like me logo Genes that share ontologies with TNC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNC Gene

Pathways & Interactions for TNC Gene

genes like me logo Genes that share pathways with TNC: view

Gene Ontology (GO) - Biological Process for TNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0007155 cell adhesion IEA --
GO:0007162 negative regulation of cell adhesion IEA --
GO:0007528 neuromuscular junction development IEA --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with TNC: view

No data available for SIGNOR curated interactions for TNC Gene

Drugs & Compounds for TNC Gene

(19) Drugs for TNC Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NEURADIAB Pharma 0

(23) Additional Compounds for TNC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNC: view

Transcripts for TNC Gene

Unigene Clusters for TNC Gene

Tenascin C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TNC
  • Applied Biological Materials Clones for TNC
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TNC Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ·
SP1: -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: -
SP7:
SP8: -
SP9: - - - - - - - -

ExUns: 18c ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1:
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TNC Gene

GeneLoc Exon Structure for
TNC
ECgene alternative splicing isoforms for
TNC

Expression for TNC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNC Gene

This gene is overexpressed in Artery - Tibial (x11.4) and Colon - Sigmoid (x5.9).

Protein differential expression in normal tissues from HIPED for TNC Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (43.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNC Gene



NURSA nuclear receptor signaling pathways regulating expression of TNC Gene:

TNC

SOURCE GeneReport for Unigene cluster for TNC Gene:

Hs.143250

Evidence on tissue expression from TISSUES for TNC Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Bone marrow(4)
  • Intestine(3.7)
  • Lung(3.7)
  • Gall bladder(3.2)
  • Bone(2.9)
  • Kidney(2.7)
  • Heart(2.3)
  • Skin(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TNC Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
Organs:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • head
  • inner ear
  • middle ear
  • outer ear
Thorax:
  • heart
  • heart valve
Limb:
  • forearm
General:
  • peripheral nerve
  • peripheral nervous system
genes like me logo Genes that share expression patterns with TNC: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TNC Gene

Orthologs for TNC Gene

This gene was present in the common ancestor of animals.

Orthologs for TNC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNC 33 34
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia TNC 33 34
  • 87.52 (n)
cow
(Bos Taurus)
Mammalia TNC 34
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnc 33 16 34
  • 74.06 (n)
rat
(Rattus norvegicus)
Mammalia Tnc 33
  • 73.97 (n)
oppossum
(Monodelphis domestica)
Mammalia TNC 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNC 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNC 33 34
  • 62.98 (n)
lizard
(Anolis carolinensis)
Reptilia TNC 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnc 33
  • 58.62 (n)
Str.15574 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24480 33
zebrafish
(Danio rerio)
Actinopterygii tnc 34
  • 55 (a)
OneToMany
LOC100149028 33
  • 54.7 (n)
CABZ01048373.1 34
  • 45 (a)
OneToMany
tenc 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4969 33
fruit fly
(Drosophila melanogaster)
Insecta CG5550 35
  • 43 (a)
CG1791 35
  • 40 (a)
CG30280 35
  • 39 (a)
CG30281 35
  • 39 (a)
BG:DS00180.10 35
  • 31 (a)
BG:DS00180.14 35
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToMany
Species where no ortholog for TNC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNC Gene

ENSEMBL:
Gene Tree for TNC (if available)
TreeFam:
Gene Tree for TNC (if available)

Paralogs for TNC Gene

Paralogs for TNC Gene

Pseudogenes.org Pseudogenes for TNC Gene

genes like me logo Genes that share paralogs with TNC: view

Variants for TNC Gene

Sequence variations from dbSNP and Humsavar for TNC Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs137933052 Pathogenic, Deafness, autosomal dominant, 56 (DFNA56) [MIM:615629] 115,041,016(+) CTCCA(C/T)GCCAG reference, missense
rs431905513 Pathogenic, Deafness, autosomal dominant, 56 (DFNA56) [MIM:615629] 115,040,947(-) CATTC(A/T)CCACA reference, missense
rs1057519148 Likely pathogenic 115,059,864(-) AGCCC(A/G)GAACC intron-variant, reference, missense
rs145086096 Benign 115,086,389(+) ACAGC(A/C/G)GCCCC reference, missense
rs1000037085 -- 115,116,928(+) AAGAC(A/T)GGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNC Gene

Variant ID Type Subtype PubMed ID
dgv4130n106 CNV deletion 24896259
esv1008522 CNV deletion 20482838
esv1713245 CNV deletion 17803354
esv21967 CNV gain 19812545
esv2422541 CNV deletion 19546169
esv2738965 CNV deletion 23290073
esv2738966 CNV deletion 23290073
esv2738967 CNV deletion 23290073
esv3545358 CNV deletion 23714750
esv3825 CNV loss 18987735
nsv1076200 CNV deletion 25765185
nsv1121699 CNV deletion 24896259
nsv1144289 CNV deletion 24896259
nsv1152680 CNV deletion 26484159
nsv519131 CNV loss 19592680
nsv615250 CNV loss 21841781
nsv7434 OTHER inversion 18451855
nsv831696 CNV gain 17160897
nsv831697 CNV loss 17160897
nsv957714 CNV deletion 24416366

Variation tolerance for TNC Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.84; 98.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNC Gene

Human Gene Mutation Database (HGMD)
TNC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNC Gene

Disorders for TNC Gene

MalaCards: The human disease database

(19) MalaCards diseases for TNC Gene - From: HGMD, OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal dominant 56
  • autosomal dominant nonsyndromic deafness 56
autosomal dominant non-syndromic sensorineural deafness type dfna
  • autosomal dominant isolated neurosensory deafness type dfna
bullous keratopathy
interstitial pneumonitis, desquamative, familial
  • desquamative interstitial pneumonia
tetanus neonatorum
  • neonatal tetanus
- elite association - COSMIC cancer census association via MalaCards
Search TNC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TENA_HUMAN
  • Deafness, autosomal dominant, 56 (DFNA56) [MIM:615629]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with post-lingual onset. {ECO:0000269 PubMed:23936043}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TNC

Genetic Association Database (GAD)
TNC
Human Genome Epidemiology (HuGE) Navigator
TNC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNC
genes like me logo Genes that share disorders with TNC: view

No data available for Genatlas for TNC Gene

Publications for TNC Gene

  1. Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies. (PMID: 1707164) Siri A … Zardi L (Nucleic acids research 1991) 2 3 4 22 60
  2. Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss. (PMID: 23936043) Zhao Y … Wang Q (PloS one 2013) 2 3 4 60
  3. Human tenascin gene. Structure of the 5'-region, identification, and characterization of the transcription regulatory sequences. (PMID: 7531707) Gherzi R … Zardi L (The Journal of biological chemistry 1995) 3 4 22 60
  4. The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats. (PMID: 1704365) Nies DE … Stefansson K (The Journal of biological chemistry 1991) 2 3 4 60
  5. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S … Sun J (Carcinogenesis 2012) 3 45 60

Products for TNC Gene

  • Addgene plasmids for TNC

Sources for TNC Gene

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