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Aliases for TMX4 Gene

Aliases for TMX4 Gene

  • Thioredoxin-Related Transmembrane Protein 4 2 3
  • Thioredoxin Domain-Containing Protein 13 3 4
  • Thioredoxin Domain Containing 13 2 3
  • TXNDC13 3 4
  • Protein Disulfide Isomerase Family A, Member 14 3
  • Protein Disulfide Isomerase Family A 2
  • DJ971N18.2 3
  • Member 14 2
  • KIAA1162 4
  • PDIA14 3

External Ids for TMX4 Gene

Previous Symbols for TMX4 Gene

  • TXNDC13

Summaries for TMX4 Gene

GeneCards Summary for TMX4 Gene

TMX4 is a Protein Coding gene. An important paralog of this gene is TMX1.

Gene Wiki entry for TMX4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMX4 Gene

Genomics for TMX4 Gene

Genomic Location for TMX4 Gene

7,977,348 bp from pter
8,019,829 bp from pter
42,482 bases
Minus strand

Genomic View for TMX4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMX4 Gene

Regulatory Elements for TMX4 Gene

Proteins for TMX4 Gene

  • Protein details for TMX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin-related transmembrane protein 4
    Protein Accession:
    Secondary Accessions:
    • Q8N4P7
    • Q8NCC1
    • Q9UJA1
    • Q9ULQ8

    Protein attributes for TMX4 Gene

    349 amino acids
    Molecular mass:
    38952 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB56344.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMX4 Gene

Proteomics data for TMX4 Gene at MOPED

Post-translational modifications for TMX4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys115

Other Protein References for TMX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMX4 Gene

Domains for TMX4 Gene

Gene Families for TMX4 Gene

  • PDI :Protein disulfide isomerases

Protein Domains for TMX4 Gene

Suggested Antigen Peptide Sequences for TMX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 thioredoxin domain.:
    • Q9H1E5
genes like me logo Genes that share domains with TMX4: view

Function for TMX4 Gene

Gene Ontology (GO) - Molecular Function for TMX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IBA --
genes like me logo Genes that share ontologies with TMX4: view

Phenotypes for TMX4 Gene

genes like me logo Genes that share phenotypes with TMX4: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMX4 Gene

Localization for TMX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMX4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TMX4 Gene COMPARTMENTS Subcellular localization image for TMX4 gene
Compartment Confidence
endoplasmic reticulum 3
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMX4: view

Pathways for TMX4 Gene

SuperPathways for TMX4 Gene

No Data Available

Interacting Proteins for TMX4 Gene

Gene Ontology (GO) - Biological Process for TMX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0034976 response to endoplasmic reticulum stress IBA --
GO:0045454 cell redox homeostasis IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with TMX4: view

No data available for Pathways by source for TMX4 Gene

Transcripts for TMX4 Gene

mRNA/cDNA for TMX4 Gene

Unigene Clusters for TMX4 Gene

Thioredoxin-related transmembrane protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMX4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - -
SP2: -
SP4: - -
SP5: - - - -

Relevant External Links for TMX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMX4 Gene

mRNA expression in normal human tissues for TMX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMX4 Gene

SOURCE GeneReport for Unigene cluster for TMX4 Gene Hs.169358

genes like me logo Genes that share expressions with TMX4: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMX4 Gene

Orthologs for TMX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMX4 35
  • 99.14 (n)
  • 100 (a)
TMX4 36
  • 100 (a)
(Bos Taurus)
Mammalia -- 36
  • 63 (a)
TMX4 35
  • 86.63 (n)
  • 81.98 (a)
TMX4 36
  • 82 (a)
(Canis familiaris)
Mammalia TMX4 35
  • 86.67 (n)
  • 81.05 (a)
TMX4 36
  • 79 (a)
(Mus musculus)
Mammalia Tmx4 35
  • 83.78 (n)
  • 82.58 (a)
Tmx4 16
Tmx4 36
  • 82 (a)
(Monodelphis domestica)
Mammalia TMX4 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia TMX4 36
  • 49 (a)
(Rattus norvegicus)
Mammalia Tmx4 35
  • 84.44 (n)
  • 84.64 (a)
(Gallus gallus)
Aves TMX4 35
  • 65.2 (n)
  • 57.51 (a)
TMX4 36
  • 44 (a)
(Anolis carolinensis)
Reptilia TMX4 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19537 35
tmx4 35
  • 64.64 (n)
  • 54.78 (a)
(Danio rerio)
Actinopterygii tmx4 35
  • 57.47 (n)
  • 48.71 (a)
tmx4 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5554 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea dpy-11 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for TMX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMX4 Gene

Gene Tree for TMX4 (if available)
Gene Tree for TMX4 (if available)

Paralogs for TMX4 Gene

Paralogs for TMX4 Gene

Selected SIMAP similar genes for TMX4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMX4: view

Variants for TMX4 Gene

Sequence variations from dbSNP and Humsavar for TMX4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs8764 -- 7,981,425(-) AAAAT(G/T)GTTTT utr-variant-3-prime
rs719510 -- 7,993,136(+) TCAGT(A/G)AGATA intron-variant
rs932303 -- 8,000,031(-) ACTTA(C/T)AGTAA intron-variant
rs932304 -- 8,000,000(-) TTTAT(C/G)TCTAT intron-variant
rs932305 -- 7,999,643(-) GTTTT(A/T)CTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMX4 Gene

Variant ID Type Subtype PubMed ID
nsv912652 CNV Gain 21882294
esv2422203 CNV Duplication 17116639

Relevant External Links for TMX4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMX4 Gene

Disorders for TMX4 Gene

Relevant External Links for TMX4

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with TMX4: view

No data available for UniProtKB/Swiss-Prot for TMX4 Gene

Publications for TMX4 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4

Products for TMX4 Gene

Sources for TMX4 Gene

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