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Aliases for TMX4 Gene

Aliases for TMX4 Gene

  • Thioredoxin Related Transmembrane Protein 4 2 3
  • Thioredoxin-Related Transmembrane Protein 4 2 5
  • Thioredoxin Domain-Containing Protein 13 3 4
  • Thioredoxin Domain Containing 13 2 3
  • TXNDC13 3 4
  • Protein Disulfide Isomerase Family A, Member 14 3
  • Protein Disulfide Isomerase Family A 2
  • DJ971N18.2 3
  • Member 14 2
  • KIAA1162 4
  • PDIA14 3

External Ids for TMX4 Gene

Previous HGNC Symbols for TMX4 Gene

  • TXNDC13

Summaries for TMX4 Gene

GeneCards Summary for TMX4 Gene

TMX4 (Thioredoxin Related Transmembrane Protein 4) is a Protein Coding gene. GO annotations related to this gene include protein disulfide isomerase activity. An important paralog of this gene is TMX1.

Gene Wiki entry for TMX4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMX4 Gene

Genomics for TMX4 Gene

Regulatory Elements for TMX4 Gene

Enhancers for TMX4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMX4 on UCSC Golden Path with GeneCards custom track

Promoters for TMX4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMX4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMX4 Gene

7,977,348 bp from pter
8,019,829 bp from pter
42,482 bases
Minus strand

Genomic View for TMX4 Gene

Genes around TMX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMX4 Gene

Proteins for TMX4 Gene

  • Protein details for TMX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin-related transmembrane protein 4
    Protein Accession:
    Secondary Accessions:
    • Q8N4P7
    • Q8NCC1
    • Q9UJA1
    • Q9ULQ8

    Protein attributes for TMX4 Gene

    349 amino acids
    Molecular mass:
    38952 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB56344.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMX4 Gene

Proteomics data for TMX4 Gene at MOPED

Post-translational modifications for TMX4 Gene

  • Ubiquitination at Lys 115
  • Modification sites at PhosphoSitePlus

Other Protein References for TMX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMX4 Gene

Domains & Families for TMX4 Gene

Gene Families for TMX4 Gene

Protein Domains for TMX4 Gene

Suggested Antigen Peptide Sequences for TMX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 thioredoxin domain.
  • Contains 1 thioredoxin domain.
genes like me logo Genes that share domains with TMX4: view

Function for TMX4 Gene

genes like me logo Genes that share phenotypes with TMX4: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMX4 Gene

Localization for TMX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMX4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TMX4 Gene COMPARTMENTS Subcellular localization image for TMX4 gene
Compartment Confidence
endoplasmic reticulum 3
extracellular 2
nucleus 2
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TMX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMX4: view

Pathways & Interactions for TMX4 Gene

SuperPathways for TMX4 Gene

No Data Available

Interacting Proteins for TMX4 Gene

Gene Ontology (GO) - Biological Process for TMX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0034976 response to endoplasmic reticulum stress IBA --
genes like me logo Genes that share ontologies with TMX4: view

No data available for Pathways by source and SIGNOR curated interactions for TMX4 Gene

Drugs & Compounds for TMX4 Gene

No Compound Related Data Available

Transcripts for TMX4 Gene

Unigene Clusters for TMX4 Gene

Thioredoxin-related transmembrane protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMX4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - -
SP2: -
SP4: - -
SP5: - - - -

Relevant External Links for TMX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMX4 Gene

mRNA expression in normal human tissues for TMX4 Gene

Protein differential expression in normal tissues from HIPED for TMX4 Gene

This gene is overexpressed in Nasal epithelium (21.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMX4 Gene

SOURCE GeneReport for Unigene cluster for TMX4 Gene Hs.169358

genes like me logo Genes that share expression patterns with TMX4: view

Protein tissue co-expression partners for TMX4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMX4 Gene

Orthologs for TMX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMX4 35
  • 86.63 (n)
  • 81.98 (a)
TMX4 36
  • 82 (a)
-- 36
  • 63 (a)
(Canis familiaris)
Mammalia TMX4 35
  • 86.67 (n)
  • 81.05 (a)
TMX4 36
  • 79 (a)
(Mus musculus)
Mammalia Tmx4 35
  • 83.78 (n)
  • 82.58 (a)
Tmx4 16
Tmx4 36
  • 82 (a)
(Pan troglodytes)
Mammalia TMX4 35
  • 99.14 (n)
  • 100 (a)
TMX4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmx4 35
  • 84.44 (n)
  • 84.64 (a)
(Monodelphis domestica)
Mammalia TMX4 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia TMX4 36
  • 49 (a)
(Gallus gallus)
Aves TMX4 35
  • 65.2 (n)
  • 57.51 (a)
TMX4 36
  • 44 (a)
(Anolis carolinensis)
Reptilia TMX4 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19537 35
tmx4 35
  • 64.64 (n)
  • 54.78 (a)
(Danio rerio)
Actinopterygii tmx4 35
  • 57.47 (n)
  • 48.71 (a)
tmx4 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5554 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea dpy-11 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for TMX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMX4 Gene

Gene Tree for TMX4 (if available)
Gene Tree for TMX4 (if available)

Paralogs for TMX4 Gene

Paralogs for TMX4 Gene

(2) SIMAP similar genes for TMX4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMX4: view

Variants for TMX4 Gene

Sequence variations from dbSNP and Humsavar for TMX4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1135711 - 7,983,829(-) TTTCT(A/G)TGTGC reference, missense
rs2076015 - 7,982,394(-) CCCCA(A/G)GAGAG reference, missense
rs8764 -- 7,981,425(-) AAAAT(G/T)GTTTT utr-variant-3-prime
rs1004042 -- 8,002,509(-) TATTC(C/T)TGGTG intron-variant
rs1012891 -- 7,999,743(-) TCCCC(A/G)GCTTC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TMX4 Gene

Variant ID Type Subtype PubMed ID
nsv912652 CNV Gain 21882294
esv2422203 CNV Duplication 17116639

Variation tolerance for TMX4 Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMX4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMX4 Gene

Disorders for TMX4 Gene

Relevant External Links for TMX4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMX4 Gene

Publications for TMX4 Gene

  1. Novel thioredoxin-related transmembrane protein TMX4 has reductase activity. (PMID: 20056998) Sugiura Y. … Nagata K. (J. Biol. Chem. 2010) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4. (PMID: 19811453) Roth D. … Ellgaard L. (Biochem. J. 2010) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for TMX4 Gene

Sources for TMX4 Gene