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TMX4 Gene

protein-coding   GIFtS: 52
GCID: GC20M007908

Thioredoxin-Related Transmembrane Protein 4

(Previous name: thioredoxin domain containing 13)
(Previous symbol: TXNDC13)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thioredoxin-Related Transmembrane Protein 41 2     Protein Disulfide Isomerase Family A1
TXNDC131 2 3     DJ971N18.22
Thioredoxin Domain Containing 131 2     PDIA142
Thioredoxin Domain-Containing Protein 132 3     Protein Disulfide Isomerase Family A, Member 142
Member 141     KIAA11623

External Ids:    HGNC: 252371   Entrez Gene: 562552   Ensembl: ENSG000001258277   UniProtKB: Q9H1E53   

Export aliases for TMX4 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMX4 Gene:
TMX4 (thioredoxin-related transmembrane protein 4) is a protein-coding gene. Diseases associated with TMX4 include tonsillitis, and thyroiditis. An important paralog of this gene is TMX1.

Gene Wiki entry for TMX4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMX4 gene promoter:
         FOXI1   HFH-3   LHX3b/Lhx3b   HNF-1   Nkx2-2   LHX3a/Lhx3a   ZID   LCR-F1   HNF-1A   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TMX4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12   Ensembl cytogenetic band:  20p12.3   HGNC cytogenetic band: 20p12

TMX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMX4 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M007908:  view genomic region     (about GC identifiers)

Start:
7,957,995 bp from pter      End:
8,000,476 bp from pter
Size:
42,482 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TMX4_HUMAN, Q9H1E5 (See protein sequence)
Recommended Name: Thioredoxin-related transmembrane protein 4 precursor  
Size: 349 amino acids; 38952 Da
Sequence caution: Sequence=CAB56344.1; Type=Erroneous initiation;
Secondary accessions: Q8N4P7 Q8NCC1 Q9UJA1 Q9ULQ8

Explore the universe of human proteins at neXtProt for TMX4: NX_Q9H1E5

Explore proteomics data for TMX4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys115
  • Modification sites at PhosphoSitePlus

  • See TMX4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066979.2  
    ENSEMBL proteins: 
     ENSP00000246024   ENSP00000435735   ENSP00000433878  

    TMX4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Cloud-Clone Corp. Proteins for TMX4

    TMX4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for TMX4
    Novus Biologicals TMX4 Antibodies
    Abcam antibodies for TMX4
    Cloud-Clone Corp. Antibodies for TMX4
    Search ThermoFisher Antibodies for TMX4
    LSBio Antibodies in human, mouse, rat for TMX4

    TMX4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMX4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMX4
    Cloud-Clone Corp. CLIAs for TMX4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PDI: Protein disulfide isomerases

    3 InterPro protein domains:
     IPR013766 Thioredoxin_domain
     IPR017937 Thioredoxin_CS
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9H1E5

    ProtoNet protein and cluster: Q9H1E5

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TMX4_HUMAN, Q9H1E5
    Similarity: Contains 1 thioredoxin domain


    TMX4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003756protein disulfide isomerase activity IBA--
         
    TMX4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TMX4:
     Decreased viability with pacli  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMX4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMX4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMX4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMX4

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMX4:
    hsa-mir-20a-5p (MIRT050532), hsa-mir-324-3p (MIRT042945), hsa-mir-197-3p (MIRT048092), hsa-mir-21-5p (MIRT030889), hsa-mir-26b-5p (MIRT029647)

    Block miRNA regulation of human, mouse, rat TMX4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMX4 (see all 9):
    hsa-miR-31 hsa-miR-100* hsa-miR-520d-5p hsa-miR-509-5p hsa-miR-219-5p hsa-miR-508-3p hsa-miR-1252 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidTMX4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMX4
    Predesigned siRNA for gene silencing in human, mouse, rat TMX4

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TMX4

    Clone
    Products:
         
    OriGene clones in human, mouse for TMX4 (see all 6)
    OriGene ORF clones in mouse, rat for TMX4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMX4 (NM_021156)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMX4

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TMX4
    Browse ESI BIO Cell Lines and PureStem Progenitors for TMX4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMX4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMX4_HUMAN, Q9H1E5: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum3
    extracellular2
    cytosol1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IBA--
    GO:0016021integral component of membrane IEA--

    TMX4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMX4
    Interactions:

        Search GeneGlobe Interaction Network for TMX4

    Selected Interacting proteins for TMX4 (Q9H1E52, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC42P609533I2D: score=2 
    NR2F6P105883I2D: score=1 
    CANXP278242MINT-8374574
    TMX1Q9H3N12MINT-8374574
    TMX2Q9Y3202MINT-8374574
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IBA--
    GO:0034976response to endoplasmic reticulum stress IBA--
    GO:0045454cell redox homeostasis IEA--
    GO:0055114oxidation-reduction process IEA--

    TMX4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMX4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMX4 gene: 
    NM_021156.2  

    Unigene Cluster for TMX4:

    Thioredoxin-related transmembrane protein 4
    Hs.169358  [show with all ESTs]
    Unigene Representative Sequence: BC044777
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246024(uc002wmx.1) ENST00000527925 ENST00000462384 ENST00000530935

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMX4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMX4 (see all 9):
    hsa-miR-31 hsa-miR-100* hsa-miR-520d-5p hsa-miR-509-5p hsa-miR-219-5p hsa-miR-508-3p hsa-miR-1252 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidTMX4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMX4
    Predesigned siRNA for gene silencing in human, mouse, rat TMX4
    Clone
    Products:
         
    OriGene clones in human, mouse for TMX4 (see all 6)
    OriGene ORF clones in mouse, rat for TMX4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMX4 (NM_021156)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMX4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMX4
    OriGene qSTAR qPCR primer pairs in human, mouse for TMX4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMX4
      QuantiTect SYBR Green Assays in human, mouse, rat TMX4
      QuantiFast Probe-based Assays in human, mouse, rat TMX4

    Additional mRNA sequence: 

    AB032988.1 AK074838.1 AK075404.1 AK226005.1 AL118494.1 AY359004.1 BC021964.2 BC033787.1 
    BC044777.1 

    8 DOTS entries:

    DT.445273  DT.100786185  DT.95324971  DT.120839319  DT.95198710  DT.100669915  DT.100776612  DT.91695874 

    Selected AceView cDNA sequences (see all 413):

    AI005473 AA568896 BQ893174 BE677509 AW592162 N51756 AA579902 AI828027 
    AI127993 BU158287 AA923377 AW161788 BU185149 AI587514 AA412068 CA437042 
    BQ679131 CD677286 BF971090 BQ879302 CB240805 BU168271 BE221664 N47004 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TMX4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
    SP1:        -     -                                                               
    SP2:              -                                                               
    SP3:                                                                              
    SP4:                          -     -                                             
    SP5:        -     -           -     -                                             


    ECgene alternative splicing isoforms for TMX4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMX4 expression in normal human tissues (normalized intensities)      TMX4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTGTGTTT
    TMX4 Expression
    About this image


    TMX4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    TMX4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMX4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.169358
        Custom PCR Arrays for TMX4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMX4
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    QuantiFast Probe-based Assays in human, mouse, rat TMX4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMX4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMX4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmx41 , 5 thioredoxin-related transmembrane protein 41, 5 83.78(n)1
    82.58(a)1
      2 (65.66 cM)5
    528371  NM_029148.11  NP_083424.11 
     1345941855 
    chicken
    (Gallus gallus)
    Aves TMX41 thioredoxin-related transmembrane protein 4 65.2(n)
    57.51(a)
      416729  NM_001199408.1  NP_001186337.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMX46
    thioredoxin-related transmembrane protein 4
    52(a)
    1 ↔ 1
    1(135860852-135874646)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.195372 Transcribed sequence with weak similarity to protein more 75.28(n)    CF378122.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmx41 thioredoxin-related transmembrane protein 4 57.47(n)
    48.71(a)
      792311  NM_001030159.1  NP_001025330.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55546
    --
    29(a)
    1 → many
    2R(19732415-19734547)
    worm
    (Caenorhabditis elegans)
    Secernentea dpy-116
    Protein DPY-11 (dpy-11) mRNA, complete cds
    33(a)
    1 → many
    V(6511547-6515240) WBGene00001073


    ENSEMBL Gene Tree for TMX4 (if available)
    TreeFam Gene Tree for TMX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMX4 gene
    TMX12  
    2 SIMAP similar genes for TMX4 using alignment to 3 protein entries:     TMX4_HUMAN (see all proteins):
    TMX1    TXNDC

    TMX4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMX4 (see all 857)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs60863031,2
    C,F,H--7908349(+) CCCACC/AAGTGA 1 -- ds5001 ese313Minor allele frequency- A:0.03NS EA NA 1648
    rs1511557991,2
    --7908409(+) TAGAAA/GTATAC 1 -- ds50010--------
    rs1180438391,2
    C,F--7908450(+) TTTTAG/CAATTT 1 -- ds50011Minor allele frequency- C:0.04EA 120
    rs60554341,2
    H--7908491(+) TCTAAG/AGAGCA 1 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs60554361,2
    H--7908568(+) AATCAG/AGTAAG 1 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs114833441,2
    C--7908592(+) TTTTT-/TAAGGA 1 -- ds5001 trp30--------
    rs10580291,2
    C,F,O,A,H--7908607(-) ATTTCT/CTTAAA 1 -- ut3127Minor allele frequency- C:0.25MN NS EA NA WA CSA 2384
    rs1997208301,2
    --7908607(+) TTTAA-/GGAAAT 1 -- ut310--------
    rs2004794341,2
    --7908927(+) AACTT-/AAAAAA 1 -- ut310--------
    rs87641,2
    C,F,O,A,H--7908964(-) AAAATT/GGTTTT 1 -- ut3115Minor allele frequency- G:0.12MN NS EA NA 1526

    HapMap Linkage Disequilibrium report for TMX4 (7957995 - 8000476 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TMX4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422203CNV Duplication17116639
    nsv912652CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMX4
    DNA2.0 Custom Variant and Variant Library Synthesis for TMX4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for TMX4:    About MalaCards
    tonsillitis    thyroiditis    cerebritis    endotheliitis
    prostatitis


    TMX4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMX4

    Export disorders for TMX4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMX4 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with TMX4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    6. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (DNA Res. 1999)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4. (PubMed id 19811453)1 Roth D....Ellgaard L. (Biochem. J. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56255 HGNC: 25237 AceView: DJ971N18.2 Ensembl:ENSG00000125827 euGenes: HUgn56255
    ECgene: TMX4 H-InvDB: TMX4

    (According to HUGE)
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    HUGE: KIAA1162

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMX4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMX4 gene:
    Search GeneIP for patents involving TMX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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