TMX4 Gene
protein-coding GIFtS: 47
GCID: GC20M007908
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|
thioredoxin-related transmembrane protein 4(Previous name: thioredoxin domain containing 13 )
(Previous symbol: TXNDC13)
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Aliases
for TMX4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thioredoxin-Related Transmembrane Protein 41 2 | | Thioredoxin Domain Containing 131 2 | | TXNDC131 2 3 | | KIAA11621 3 | | DJ971N18.21 2 | | Thioredoxin Domain-Containing Protein 132 3 | | PDIA141 2 | | Protein Disulfide Isomerase Family A, Member 142 |
Export aliases for TMX4 gene to outside databases |
Summaries
for TMX4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for TMX4
|
Genomic Views
for TMX4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMX4 gene promoter:
FOXI1 HFH-3 LHX3b/Lhx3b HNF-1 Nkx2-2 LHX3a/Lhx3a ZID LCR-F1 HNF-1A C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMX4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMX4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p12 Ensembl cytogenetic band: 20p12.3 HGNC cytogenetic band: 20p12TMX4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M007908: view genomic region
(about GC identifiers)
Start:
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7,957,995 bp from pter |
End:
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8,000,476 bp from pter |
Size:
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42,482 bases |
Orientation:
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minus strand |
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Proteins
for TMX4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMX4_HUMAN, Q9H1E5 (See
protein sequence)Recommended Name: Thioredoxin-related transmembrane protein 4 precursor Size: 349 amino acids; 38952 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=CAB56344.1; Type=Erroneous initiation;
Secondary accessions: Q8N4P7 Q8NCC1 Q9UJA1 Q9ULQ8Explore the universe of human proteins at neXtProt for TMX4: NX_Q9H1E5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H1E5
TMX4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066979.2
ENSEMBL proteins: ENSP00000246024 ENSP00000435735 ENSP00000433878
Human Recombinant Protein Products for TMX4:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMX4 for ontologies About GeneDecksing
TMX4 Antibody Products:
Assay Products for TMX4: |
Protein
Domains /
Families
for TMX4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMX4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H1E5ProtoNet protein and cluster: Q9H1E5 1 Blocks protein family: IPB006662 Thioredoxin type domain
UniProtKB/Swiss-Prot: TMX4_HUMAN, Q9H1E5Similarity: Contains 1 thioredoxin domain |
Function
for TMX4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
2 GenomeRNAi human phenotypes for TMX4:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMX4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMX4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMX4 (NM_021156) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMX4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMX4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMX4 |
|
Pathways & Interactions
for TMX4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMX4
5/6 Interacting proteins for TMX4 (Q9H1E52, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0022900 | electron transport chain |
IEA | -- | | GO:0045454 | cell redox homeostasis |
IEA | -- |
TMX4 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMX4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMX4
Search CenterWatch for drugs/clinical trials and news about TMX4
|
Transcripts
for TMX4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMX4 gene: NM_021156.2 Unigene Cluster for TMX4: Thioredoxin-related transmembrane protein 4 Hs.169358 [show with all ESTs]Unigene Representative Sequence: BC0447774 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000246024(uc002wmx.1) ENST00000527925 ENST00000462384 ENST00000530935
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMX4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMX4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMX4 (NM_021156) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMX4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMX4 |
Additional cDNA sequence: AB032988.1 AK074838.1 AK075404.1 AK226005.1 AL118494.1 AY359004.1 BC021964.2 BC033787.1 BC044777.1 8 DOTS entries: DT.445273 DT.100786185 DT.95324971 DT.120839319 DT.95198710 DT.100669915 DT.100776612 DT.91695874 24/413 AceView cDNA sequences (see all 413): AA469995 AL118494 BM932125 AA405350 AI687488 AI828027 CA445931 CR622965 BM311846 CR598899 BF971090 AI240447 BQ581462 AI587514 BQ045002 BM930559 BQ893174 CB216977 AW592162 BU158287 CA437042 AI831626 BQ879302 BU185149
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TMX4 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 |
|---|
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| SP1: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMX4
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Expression
for TMX4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMX4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTGTGTTT
About this image
See TMX4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMX4
SOURCE GeneReport for Unigene cluster: Hs.169358
SABiosciences Custom PCR Arrays for TMX4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMX4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMX4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMX4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMX4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMX4 |
Orthologs
for TMX4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMX4 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for TMX4 (if available)
TreeFam Gene Tree for TMX4 (if available) |
Paralogs
for TMX4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMX4 gene
- TMX12
2 SIMAP similar genes for TMX4 using alignment to 3 protein entries: TMX4_HUMAN (see all proteins):TMX1 TXNDC
TMX4 for paralogs About GeneDecksing
|
Genomic Variants
for TMX4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMX4 (7957995 - 8000476 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMX4
1 CNV: 5346 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMX4 |
|
Disorders
/ Diseases
for TMX4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMX4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMX4 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with TMX4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (1999)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A di-arginine motif contributes to the ER localizatio n of the type I transmembrane ER oxidoreductase TMX4. (PubMed id 19811453)1 Roth D....Ellgaard L. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Novel thioredoxin-related transmembrane protein TMX4 has reductase activity. (PubMed id 20056998)1 Sugiura Y....Nagata K. (2010)
|
External Searches for TMX4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMX4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMX4 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TMX4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMX4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMX4 gene:
Search GeneIP for patents involving TMX4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMX4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMX4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMX4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMX4 | | OriGene 3'-UTR Clone for TMX4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMX4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMX4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMX4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMX4 | | OriGene Custom Protein Services for TMX4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMX4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMX4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMX4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMX4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMX4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMX4 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMX4 |
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 | | | TMX4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMX4 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TMX4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMX4 |
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