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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMX3 Gene

protein-coding   GIFtS: 56
GCID: GC18M066340

Thioredoxin-Related Transmembrane Protein 3

(Previous name: thioredoxin domain containing 10)
(Previous symbol: TXNDC10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thioredoxin-Related Transmembrane Protein 31 2 3     Protein Disulfide Isomerase Family A1
TXNDC101 2 3     PDIA132
Thioredoxin Domain Containing 101 2     Protein Disulfide Isomerase Family A, Member 132
Thioredoxin Domain-Containing Protein 102 3     Protein Disulfide-Isomerase TMX32
EC 5.3.4.13 8     KIAA18303
Member 131     

External Ids:    HGNC: 247181   Entrez Gene: 544952   Ensembl: ENSG000001664797   UniProtKB: Q96JJ73   

Export aliases for TMX3 gene to outside databases

Previous GC identifers: GC18M064493 GC18M063058


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMX3 Gene: 
TMX3 (thioredoxin-related transmembrane protein 3) is a protein-coding gene. Diseases associated with TMX3 include congenital diaphragmatic hernia, and hernia. GO annotations related to this gene include electron carrier activity and protein disulfide isomerase activity. An important paralog of this gene is PDIA4.

UniProtKB/Swiss-Prot: TMX3_HUMAN, Q96JJ7
Function: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds.
May act as a dithiol oxidase

Gene Wiki entry for TMX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_025028.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMX3 gene promoter:
         GCNF-1   GCNF   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMX3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22   Ensembl cytogenetic band:  18q22.1   HGNC cytogenetic band: 18q22

TMX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMX3 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M066340:  view genomic region     (about GC identifiers)

Start:
66,340,925 bp from pter      End:
66,382,535 bp from pter
Size:
41,611 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMX3_HUMAN, Q96JJ7 (See protein sequence)
Recommended Name: Protein disulfide-isomerase TMX3 precursor  
Size: 454 amino acids; 51872 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein
Sequence caution: Sequence=BAA91381.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB47459.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KV75 Q52LT7 Q8N5J0 Q9NWJ9
Alternative splicing: 2 isoforms:  Q96JJ7-1   Q96JJ7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMX3: NX_Q96JJ7

Explore proteomics data for TMX3 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96JJ7

  • 4/7 DME Specific Peptides for TMX3 (Q96JJ7) (see all 7)
     RTKDDII  VVLNTSNQQYFL  YSSIASEFGVRG  LYELGDTGKLVA 

    TMX3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMX3 Protein Expression
    REFSEQ proteins: NP_061895.3  
    ENSEMBL proteins: 
     ENSP00000299608   ENSP00000456587   ENSP00000458132   ENSP00000402605   ENSP00000457262  
     ENSP00000456453   ENSP00000455234   ENSP00000457074   ENSP00000444954  

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    Novus Biologicals TMX3 Protein
    Novus Biologicals TMX3 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMX3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0009986cell surface IDA19995400
    GO:0016021integral to membrane IEA--

    TMX3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PDI: Protein disulfide isomerases

    4 InterPro protein domains:
     IPR013766 Thioredoxin_domain
     IPR017937 Thioredoxin_CS
     IPR005746 Thioredoxin
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q96JJ7

    ProtoNet protein and cluster: Q96JJ7

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TMX3_HUMAN, Q96JJ7
    Domain: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By
    similarity)
    Similarity: Belongs to the protein disulfide isomerase family
    Similarity: Contains 1 thioredoxin domain


    TMX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMX3_HUMAN, Q96JJ7
    Function: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds.
    May act as a dithiol oxidase
    Catalytic activity: Catalyzes the rearrangement of -S-S- bonds in proteins
    Biophysicochemical properties: Redox potential: E(0) is -157 mV;
    Induction: Not up-regulated by unfolded protein response (UPR)

         Enzyme Number (IUBMB): EC 5.3.4.11 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003756protein disulfide isomerase activity IEA--
    GO:0005509calcium ion binding ----
    GO:0009055electron carrier activity IEA--
    GO:0015035protein disulfide oxidoreductase activity IEA--
    GO:0016853isomerase activity ----
         
    TMX3 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidTMX3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMX3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/10 Interacting proteins for TMX3 (Q96JJ72, 3 ENSP000002996084) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMX1Q9H3N12MINT-8374553 MINT-8374574 MINT-8379200
    TMX2Q9Y3202MINT-8374553 MINT-8374574 MINT-8379200
    BREQ9NXR73, ENSP000003434124I2D: score=2 STRING: ENSP00000343412
    CANXP278242MINT-8374574 MINT-8379200
    ATG10Q9H0Y03I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006662glycerol ether metabolic process IEA--
    GO:0045454cell redox homeostasis IEA--

    TMX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMX3

    Search CenterWatch for drugs/clinical trials and news about TMX3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMX3 gene: 
    NM_019022.3  

    Unigene Cluster for TMX3:

    Thioredoxin-related transmembrane protein 3
    Hs.440534  [show with all ESTs]
    Unigene Representative Sequence: BX647846
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299608(uc002lkf.3 uc010xez.2) ENST00000578816 ENST00000564631
    ENST00000566135 ENST00000578765 ENST00000566887 ENST00000569053 ENST00000443099(uc010xfa.1)
    ENST00000562706(uc002lkg.4) ENST00000564008 ENST00000565918 ENST00000580785
    ENST00000569982 ENST00000544714
    miRNA
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    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate TMX3 (see all 53):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-607 hsa-miR-3607-3p hsa-miR-3146 hsa-miR-106a hsa-miR-374c hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidTMX3 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMX3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMX3

    Additional mRNA sequence: 

    AB058733.1 AK000800.1 AK025025.1 AK122715.1 AK295551.1 AK307269.1 AK310389.1 AL832341.1 
    AL832356.1 BC007690.2 BC018981.2 BC032325.2 BC093792.1 BC093794.1 BC107422.1 BC143400.1 
    BX647846.1 

    15 DOTS entries:

    DT.111940  DT.92428462  DT.100692776  DT.75176531  DT.95265677  DT.100782405  DT.121085015  DT.121085046 
    DT.91653114  DT.121085011  DT.121085058  DT.75120733  DT.92056442  DT.95235894  DT.91853347 

    24/141 AceView cDNA sequences (see all 141):

    BC018981 AA384267 AA416933 BE503286 NM_019022 BQ027526 BI819213 BI915934 
    N22084 AK000800 AV707938 AA330819 AI373289 AL832356 AA195326 BC007690 
    BX647846 BI493204 AI373582 R51954 BQ445816 BU180648 BQ433483 AI810971 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TMX3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                          -                       -                             -                 -                                             
    SP2:                          -                       -           -                 -                                                               
    SP3:                          -                       -                                                                                             
    SP4:                          -                       -     -                                                                                       
    SP5:                                                  -     -                                                                                       


    ECgene alternative splicing isoforms for TMX3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMX3 expression in normal human tissues (normalized intensities)      TMX3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATTCTGCC
    TMX3 Expression
    About this image


    TMX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Granulocytes Peripheral Blood
             lung ; macrophages   
             cd4+ t cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             bronchus ; respiratory epithelial cells   
             bronchoalveolar lavage cells   

    See TMX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMX3

    SOURCE GeneReport for Unigene cluster: Hs.440534

    UniProtKB/Swiss-Prot: TMX3_HUMAN, Q96JJ7
    Tissue specificity: Widely expressed. Expressed in brain, testis, lung, skin, kidney, uterus, bone, stomach,
    liver, prostate, placenta, eye and muscle

        SABiosciences Custom PCR Arrays for TMX3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMX3 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmx31 , 5 thioredoxin-related transmembrane protein 31, 5 90.5(n)1
    92.43(a)1
      18 (59.37 cM)5
    679881  NM_198295.21  NP_938037.21 
     905101545 
    chicken
    (Gallus gallus)
    Aves TMX31 thioredoxin-related transmembrane protein 3 76.16(n)
    79.73(a)
      421027  XM_419113.3  XP_419113.3 
    lizard
    (Anolis carolinensis)
    Reptilia TMX36
    thioredoxin-related transmembrane protein 3
    71(a)
    1 ↔ 1
    4(46418469-46448796)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD363155.12   -- 73.69(n)    CD363155.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1528081 zgc:152808 63.1(n)
    64.13(a)
      553250  NM_001045561.1  NP_001039026.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50271 CG5027 46.68(n)
    30.61(a)
      39775  NM_140590.3  NP_648847.3 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK973.111 Protein ZK973.11 46.58(n)
    32.91(a)
      172039  NM_058960.3  NP_491361.1 


    ENSEMBL Gene Tree for TMX3 (if available)
    TreeFam Gene Tree for TMX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMX3 gene
    PDIA42  ERP272  P4HB2  PDIA22  PDIA32  PDILT2  
    18/67 SIMAP similar genes for TMX3 using alignment to 8 protein entries:     TMX3_HUMAN (see all proteins) (see all similar genes):
    TGM4    ARL6IP5    C1orf143    RBP7    ATL2    IK
    NLN    C14orf105    KIAA1651    LOC100996577    TNNT1    TUBA1C
    CALCOCO2    FLJ00047    SH2B3    ZNF257    AARSD1    EEF1E1

    TMX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/967 SNPs in TMX3 are shown (see all 967)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1811115531,2
    --66340426(+) TTGTGC/GGTCCA 1 -- ds50010--------
    rs3091981,2
    C,F,A,H--66340434(+) CCATGT/CTTTGG 1 -- ds500115Minor allele frequency- C:0.22NS EA NA WA CSA 868
    rs3091991,2
    C,F,O,A,H--66340458(+) TGCCTA/GTCACT 1 -- ds500114Minor allele frequency- G:0.20NA NS EA WA CSA 806
    rs1384465091,2
    --66340478(+) AGATAC/TGTCCT 1 -- ds50010--------
    rs1457921101,2
    C--66340648(+) TTAAG-/GATT  
            
    GATTC
    1 -- ds50010--------
    rs3092001,2
    C,F--66340663(+) TCTCAG/AAATAA 1 -- ds50012Minor allele frequency- A:0.47WA 120
    rs1386197421,2
    C--66340749(+) TTATT-/TATAA 
            
    TATAG
    1 -- ds50010--------
    rs2006489671,2
    C--66340754(+) TTATAA/GTAGAA 1 -- ds50010--------
    rs1439235151,2
    C--66340798(+) ATTCTA/GTATTT 1 -- ds50010--------
    rs3092011,2
    C,F,A,H--66340828(+) AAAAGC/TAACAC 1 -- ds500121Minor allele frequency- T:0.33NS EA NA WA CSA 2339

    HapMap Linkage Disequilibrium report for TMX3 (66340925 - 66382535 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TMX3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv458117CNV Gain19166990
    dgv3446n71CNV Gain21882294
    esv847CNV CNV17122850
    dgv1044e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for TMX3:    About MalaCards
    congenital diaphragmatic hernia    hernia    coloboma    microphthalmia
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for TMX3:
    Congenital diaphragmatic hernia

    TMX3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMX3
    Human Genome Epidemiology (HuGE) Navigator: TMX3 (1 document)

    Export disorders for TMX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMX3 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with TMX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel thioredoxin-related transmembrane protein of the endoplasmic reticulum. (PubMed id 15623505)1, 2, 3, 9 Haugstetter J.... Ellgaard L. (2005)
    2. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
    6. A male with unilateral microphthalmia reveals a role for TMX3 in eye development. (PubMed id 20485507)1, 9 Chao R....Slavotinek A. (2010)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54495 HGNC: 24718 AceView: FLJ20793 Ensembl:ENSG00000166479 euGenes: HUgn54495
    ECgene: TMX3 H-InvDB: TMX3

    (According to HUGE)
    About This Section
    HUGE: KIAA1830

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMX3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMX3 gene:
    Search GeneIP for patents involving TMX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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