Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMX3 Gene

protein-coding   GIFtS: 51
GCID: GC18M066340

thioredoxin-related transmembrane protein 3

(Previous name: thioredoxin domain containing 10 )
(Previous symbol: TXNDC10)
 Explore 5 diseases affiliated with
TMX3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TMX3    

Aliases
for TMX3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Thioredoxin-Related Transmembrane Protein 31 2 3     Thioredoxin Domain-Containing Protein 102 3
TXNDC101 2 3     EC 5.3.4.13 8
PDIA131 2     FLJ207931
Thioredoxin Domain Containing 101 2     Protein Disulfide Isomerase Family A, Member 132
KIAA18301 3     Protein Disulfide-Isomerase TMX32

External Ids:    HGNC: 247181   Entrez Gene: 544952   Ensembl: ENSG000001664797   UniProtKB: Q96JJ73   

Export aliases for TMX3 gene to outside databases

Previous GC identifers: GC18M064493 GC18M063058


Summaries
for TMX3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TMX3_HUMAN, Q96JJ7
Function: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May
act as a dithiol oxidase

Gene Wiki entry for TMX3


Genomic Views
for TMX3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMX3 gene promoter:
         GCNF-1   GCNF   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMX3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22   Ensembl cytogenetic band:  18q22.1   HGNC cytogenetic band: 18q22

TMX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMX3 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M066340:  view genomic region     (about GC identifiers)

Start:
 66,340,925 bp from pter      End:
 66,382,535 bp from pter
Size:
 41,611 bases      Orientation:
 minus strand

Proteins
for TMX3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TMX3_HUMAN, Q96JJ7 (See protein sequence)
Recommended Name: Protein disulfide-isomerase TMX3 precursor  
Size: 454 amino acids; 51872 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein
Sequence caution: Sequence=BAA91381.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB47459.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KV75 Q52LT7 Q8N5J0 Q9NWJ9
Alternative splicing: 2 isoforms:  Q96JJ7-1   Q96JJ7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMX3: NX_Q96JJ7

Post-translational modifications:

  • N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96JJ7

    • 4/7 DME Specific Peptides for TMX3 (Q96JJ7) (see all 7)
     RTKDDII  VVLNTSNQQYFL  YSSIASEFGVRG  LYELGDTGKLVA 

    TMX3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061895.3  
    ENSEMBL proteins: 
     ENSP00000299608   ENSP00000456587   ENSP00000458132   ENSP00000402605   ENSP00000457262  
     ENSP00000456453   ENSP00000455234   ENSP00000457074   ENSP00000444954  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: TMX3
    OriGene Protein Over-expression Lysate: TMX3
    OriGene Custom Protein Services for TMX3 
    GenScript Custom Purified and Recombinant Proteins Services for TMX3
    Novus Biologicals TMX3 Protein
    Novus Biologicals TMX3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TMX3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0009986cell surface IDA19995400
    GO:0016021integral to membrane IEA--


    TMX3 for ontologies           About GeneDecksing



    TMX3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TMX3 
    GenScript Custom Superior Antibodies Services for TMX3
    Novus Biologicals TMX3 Antibody
    Search for Antibodies for TMX3 at Abcam  
    Uscn Antibodies for TMX3
    Search ThermoFisher Antibodies for TMX3

    Assay Products for TMX3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMX3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TMX3

    Protein Domains /
    Families
    for TMX3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TMX3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013766 Thioredoxin_domain
     IPR017937 Thioredoxin_CS
     IPR005746 Thioredoxin
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q96JJ7

    ProtoNet protein and cluster: Q96JJ7

    1 Blocks protein family: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TMX3_HUMAN, Q96JJ7
    Domain: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)
    Similarity: Belongs to the protein disulfide isomerase family
    Similarity: Contains 1 thioredoxin domain


    Function
    for TMX3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TMX3_HUMAN, Q96JJ7
    Function: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May
    act as a dithiol oxidase
    Catalytic activity: Catalyzes the rearrangement of -S-S- bonds in proteins
    Biophysicochemical properties: Redox potential: E(0) is -157 mV;
    Induction: Not up-regulated by unfolded protein response (UPR)

    Enzyme Number (IUBMB): EC 5.3.4.11 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone: TMX3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMX3
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate TMX3 (see all 53):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-607 hsa-miR-3607-3p hsa-miR-3146 hsa-miR-106a hsa-miR-374c hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: TMX3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene 29mer shRNA kits
    OriGene siRNA: TMX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMX3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TMX3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMX3 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMX3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TMX3 (NM_019022)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMX3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TMX3
    Search LifeMap BioReagents cell lines for TMX3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMX3

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003756protein disulfide isomerase activity IEA--
    GO:0009055electron carrier activity IEA--
    GO:0015035protein disulfide oxidoreductase activity IEA--
    GO:0016853isomerase activity ----


    TMX3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for TMX3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMX3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/10 Interacting proteins for TMX3 (Q96JJ72, 3 ENSP000002996084) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMX1Q9H3N12MINT-8374553 MINT-8374574 MINT-8379200
    TMX2Q9Y3202MINT-8374553 MINT-8374574 MINT-8379200
    BREQ9NXR73, ENSP000003434124I2D: score=2 STRING: ENSP00000343412
    CANXP278242MINT-8374574 MINT-8379200
    ATG10Q9H0Y03I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006662glycerol ether metabolic process IEA--
    GO:0045454cell redox homeostasis IEA--


    TMX3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TMX3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMX3
    Search CenterWatch for drugs/clinical trials and news about TMX3 

    Transcripts
    for TMX3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TMX3 gene: 
    NM_019022.3  

    Unigene Cluster for TMX3:

    Thioredoxin-related transmembrane protein 3
    Hs.440534  [show with all ESTs]
    Unigene Representative Sequence: BX647846
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299608(uc002lkf.3 uc010xez.2) ENST00000578816 ENST00000564631
    ENST00000566135 ENST00000578765 ENST00000566887 ENST00000569053 ENST00000443099(uc010xfa.1)
    ENST00000562706(uc002lkg.4) ENST00000564008 ENST00000565918 ENST00000580785
    ENST00000569982 ENST00000544714

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TMX3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMX3
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate TMX3 (see all 53):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-607 hsa-miR-3607-3p hsa-miR-3146 hsa-miR-106a hsa-miR-374c hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: TMX3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene 29mer shRNA kits
    OriGene siRNA: TMX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMX3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMX3 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMX3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TMX3 (NM_019022)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMX3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMX3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMX3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMX3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMX3

    Additional cDNA sequence: 

    AB058733.1 AK000800.1 AK025025.1 AK122715.1 AK295551.1 AK307269.1 AK310389.1 AL832341.1 
    AL832356.1 BC007690.2 BC018981.2 BC032325.2 BC093792.1 BC093794.1 BC107422.1 BC143400.1 
    BX647846.1 

    15 DOTS entries:

    DT.111940  DT.92428462  DT.100692776  DT.75176531  DT.95265677  DT.100782405  DT.121085015  DT.121085046 
    DT.91653114  DT.121085011  DT.121085058  DT.75120733  DT.92056442  DT.95235894  DT.91853347 

    24/141 AceView cDNA sequences (see all 141):

    AV707938 NM_019022 AL832341 AI061047 BC018981 AA416933 AI091616 N22084 
    AK000800 BE503286 BQ433483 AA393208 AA195326 BI493203 AI373289 AI285767 
    AL832356 AI810971 BM782349 BI819213 AB058733 BI915934 R51954 CA406927 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TMX3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                          -                       -                             -                 -                                             
    SP2:                          -                       -           -                 -                                                               
    SP3:                          -                       -                                                                                             
    SP4:                          -                       -     -                                                                                       
    SP5:                                                  -     -                                                                                       


    ECgene alternative splicing isoforms for TMX3

    Expression
    for TMX3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATATTCTGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TMX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMX3

    SOURCE GeneReport for Unigene cluster: Hs.440534

    UniProtKB/Swiss-Prot: TMX3_HUMAN, Q96JJ7
    Tissue specificity: Widely expressed. Expressed in brain, testis, lung, skin, kidney, uterus, bone, stomach, liver,
    prostate, placenta, eye and muscle

        SABiosciences Custom PCR Arrays for TMX3
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMX3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMX3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMX3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMX3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMX3

    Orthologs
    for TMX3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TMX3 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TMX31 thioredoxin-related transmembrane protein 3 76.16(n)
    79.73(a)    		   421027  XM_419113.3  XP_419113.3 
    lizard
    (Anolis carolinensis)    		 Reptilia TMX36
    		 --
    		 73(a)
    		 1 ↔ 1
    		 4(46424353-46444232)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CD363155.12   -- 73.69(n)    CD363155.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1528081 zgc:152808 63.1(n)
    64.13(a)    		   553250  NM_001045561.1  NP_001039026.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG50271 CG5027 46.68(n)
    30.61(a)    		   39775  NM_140590.3  NP_648847.3 
    worm
    (Caenorhabditis elegans)    		 Secernentea ZK973.111 Protein ZK973.11 46.58(n)
    32.91(a)    		   172039  NM_058960.3  NP_491361.1 


    ENSEMBL Gene Tree for TMX3 (if available)
    TreeFam Gene Tree for TMX3 (if available) 

    Paralogs
    for TMX3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMX3 gene
    PDIA62  PDIA22  PDIA52  PDIA42  ERP272  DNAJC102  P4HB2  TXNDC52  
    PDIA32  PDILT2  
    18/58 SIMAP similar genes for TMX3 using alignment to 8 protein entries:     TMX3_HUMAN (see all proteins) (see all similar genes):
    TGM4    ARL6IP5    C1orf143    ATL2    IK    NLN
    C14orf105    KIAA1651    TUBA1C    CALCOCO2    FLJ00047    SH2B3
    EEF1E1    UBXN4    RFXANK    RRM2B    TBCB    ACTR10

    TMX3 for paralogs           About GeneDecksing



    Genomic Variants
    for TMX3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/861 NCBI SNPs in TMX3 are shown (see all 861)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1811115531,2
    		--66340426(+) TTGTGC/GGTCCA 1 -- ds50010--------
    rs3091981,2
    		C,F,A,H,--66340434(+) CCATGT/CTTTGG 1 -- ds500115Minor allele frequency- C:0.22NS EA NA WA CSA 868
    rs3091991,2
    		C,F,O,A,H,--66340458(+) TGCCTA/GTCACT 1 -- ds500114Minor allele frequency- G:0.20NA NS EA WA CSA 806
    rs1384465091,2
    		--66340478(+) AGATAC/TGTCCT 1 -- ds50010--------
    rs1457921101,2
    		C,--66340648(+) TTAAG-/GATT  
                GATTC     		1 -- ds50010--------
    rs3092001,2
    		C,--66340663(+) TCTCAG/AAATAA 1 -- ds50012Minor allele frequency- A:0.47WA 120
    rs1386197421,2
    		C,--66340749(+) TTATT-/TATAA 
                TATAG     		1 -- ds50010--------
    rs2006489671,2
    		C--66340754(+) TTATAA/GTAGAA 1 -- ds50010--------
    rs1439235151,2
    		--66340798(+) ATTCTA/GTATTT 1 -- ds50010--------
    rs3092011,2
    		C,F,A,H,--66340828(+) AAAAGC/TAACAC 1 -- ds500121Minor allele frequency- T:0.33NS EA NA WA CSA 2339

    HapMap Linkage Disequilibrium report for TMX3 (66340925 - 66382535 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TMX3
         1 CNV: 4061

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMX3
    DNA2.0 Custom Variant and Variant Library Synthesis for TMX3

    Disorders / Diseases
    for TMX3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TMX3 for disorders           About GeneDecksing

    5 diseases for TMX3:    About MalaCards
    congenital diaphragmatic hernia    hernia    coloboma    microphthalmia
    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: TMX3 (1 document)

    Export disorders for TMX3 gene to outside databases

    Publications
    for TMX3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMX3 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with TMX3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel thioredoxin-related transmembrane protein of the endoplasmic reticulum. (PubMed id 15623505)1, 2, 3, 9 Haugstetter J.... Ellgaard L. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
    5. A male with unilateral microphthalmia reveals a role for TMX3 in eye development. (PubMed id 20485507)1, 9 Chao R....Slavotinek A. (2010)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. (PubMed id 19995400)1 Holbrook L.M....Gibbins J.M. (2010)
    10. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)

    External Searches for TMX3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TMX3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54495 HGNC: 24718 AceView: FLJ20793 Ensembl:ENSG00000166479 euGenes: HUgn54495
    ECgene: TMX3 H-InvDB: TMX3

    Other Databases showing TMX3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1830

    Specialized Databases showing TMX3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMX3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TMX3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TMX3 gene:
    Search GeneIP for patents involving TMX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TMX3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   Browse OriGene shRNA RFPs  
     Browse OriGene 29mer shRNA kits in GFP-retroviral vector   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMX3  
     OriGene Protein Over-expression Lysate for TMX3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TMX3   OriGene 3'-UTR Clone for TMX3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMX3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMX3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for TMX3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TMX3   OriGene Custom Protein Services for TMX3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMX3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMX3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMX3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMX3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMX3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMX3
     GenScript Custom Purified and Recombinant Proteins Services for TMX3 GenScript cDNA clones with any tag delivered in your preferred vector for TMX3
     GenScript Custom Assay Services for TMX3 GenScript Custom Superior Antibodies Services for TMX3
     GenScript Custom overexpressing Cell Line Services for TMX3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TMX3 promoter
     Search Chromatin IP Primers for TMX3
     RT2 qPCR Primer Assay in human, mouse, rat TMX3
     Search GNC Networks for TMX3
     SABiosciences Custom PCR Arrays for TMX3
     Search Tocris compounds for TMX3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TMX3 antibodies
     TMX3 proteins
     TMX3 lysates
     Search for Antibodies for TMX3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TMX3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TMX3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TMX3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMX3
     SwitchGear 3'UTR luciferase reporter plasmids for TMX3
     SwitchGear Promoter luciferase reporter plasmids for TMX3
     Search ThermoFisher Antibodies for TMX3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMX3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TMX3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4