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Aliases for TMX3 Gene

Aliases for TMX3 Gene

  • Thioredoxin-Related Transmembrane Protein 3 2 3 4
  • Thioredoxin Domain-Containing Protein 10 3 4
  • Thioredoxin Domain Containing 10 2 3
  • EC 4 64
  • TXNDC10 3 4
  • Protein Disulfide Isomerase Family A, Member 13 3
  • Protein Disulfide Isomerase Family A 2
  • Protein Disulfide-Isomerase TMX3 3
  • Member 13 2
  • KIAA1830 4
  • PDIA13 3

External Ids for TMX3 Gene

Previous Symbols for TMX3 Gene

  • TXNDC10

Summaries for TMX3 Gene

GeneCards Summary for TMX3 Gene

TMX3 is a Protein Coding gene. GO annotations related to this gene include electron carrier activity and protein disulfide isomerase activity. An important paralog of this gene is PDIA3.

UniProtKB/Swiss-Prot for TMX3 Gene

  • Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase.

Gene Wiki entry for TMX3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMX3 Gene

Genomics for TMX3 Gene

Genomic Location for TMX3 Gene

68,673,688 bp from pter
68,715,298 bp from pter
41,611 bases
Minus strand

Genomic View for TMX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMX3 Gene

Regulatory Elements for TMX3 Gene

Proteins for TMX3 Gene

  • Protein details for TMX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein disulfide-isomerase TMX3
    Protein Accession:
    Secondary Accessions:
    • B3KV75
    • Q52LT7
    • Q8N5J0
    • Q9NWJ9

    Protein attributes for TMX3 Gene

    454 amino acids
    Molecular mass:
    51872 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91381.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB47459.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMX3 Gene


neXtProt entry for TMX3 Gene

Proteomics data for TMX3 Gene at MOPED

Post-translational modifications for TMX3 Gene

Domains for TMX3 Gene

Gene Families for TMX3 Gene

  • PDI :Protein disulfide isomerases

Protein Domains for TMX3 Gene


  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.:
    • Q96JJ7
  • Contains 1 thioredoxin domain.:
    • Q96JJ7
  • Belongs to the protein disulfide isomerase family.:
    • Q96JJ7
genes like me logo Genes that share domains with TMX3: view

Function for TMX3 Gene

Molecular function for TMX3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Redox potential: E(0) is -157 mV. {ECO:0000269 PubMed:15623505};
UniProtKB/Swiss-Prot CatalyticActivity: Catalyzes the rearrangement of -S-S- bonds in proteins.
UniProtKB/Swiss-Prot Function: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase.
UniProtKB/Swiss-Prot Induction: Not up-regulated by unfolded protein response (UPR).

Enzyme Numbers (IUBMB) for TMX3 Gene

Gene Ontology (GO) - Molecular Function for TMX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IBA --
GO:0005509 calcium ion binding --
GO:0005515 protein binding IPI 25416956
GO:0016853 isomerase activity --
genes like me logo Genes that share ontologies with TMX3: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMX3 Gene

Localization for TMX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMX3 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMX3 Gene COMPARTMENTS Subcellular localization image for TMX3 gene
Compartment Confidence
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for TMX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0009986 cell surface IDA 19995400
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMX3: view

Pathways for TMX3 Gene

SuperPathways for TMX3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0008152 metabolic process --
GO:0034976 response to endoplasmic reticulum stress IBA --
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with TMX3: view

No data available for Pathways by source for TMX3 Gene

Transcripts for TMX3 Gene

Unigene Clusters for TMX3 Gene

Thioredoxin-related transmembrane protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMX3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for TMX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMX3 Gene

mRNA expression in normal human tissues for TMX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMX3 Gene

SOURCE GeneReport for Unigene cluster for TMX3 Gene Hs.440534

mRNA Expression by UniProt/SwissProt for TMX3 Gene

Tissue specificity: Widely expressed. Expressed in brain, testis, lung, skin, kidney, uterus, bone, stomach, liver, prostate, placenta, eye and muscle.
genes like me logo Genes that share expressions with TMX3: view

Orthologs for TMX3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMX3 36
  • 99.49 (n)
  • 99.56 (a)
TMX3 37
  • 100 (a)
(Bos Taurus)
Mammalia TMX3 36
  • 87.37 (n)
  • 88.77 (a)
TMX3 37
  • 89 (a)
(Canis familiaris)
Mammalia TMX3 36
  • 90.8 (n)
  • 92.27 (a)
TMX3 37
  • 92 (a)
(Mus musculus)
Mammalia Tmx3 36
  • 90.5 (n)
  • 92.43 (a)
Tmx3 16
Tmx3 37
  • 91 (a)
(Monodelphis domestica)
Mammalia TMX3 37
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia TMX3 37
  • 85 (a)
(Rattus norvegicus)
Mammalia Tmx3 36
  • 88.51 (n)
  • 89.04 (a)
(Gallus gallus)
Aves TMX3 36
  • 75.79 (n)
  • 78.37 (a)
TMX3 37
  • 77 (a)
(Anolis carolinensis)
Reptilia TMX3 37
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmx3 36
  • 71.03 (n)
  • 72.28 (a)
(Danio rerio)
Actinopterygii tmx3 37
  • 49 (a)
zgc:152808 36
  • 64.55 (n)
  • 67.01 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005431 36
  • 43.54 (n)
  • 30.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5027 36
  • 46.48 (n)
  • 30.4 (a)
CG5027 37
  • 29 (a)
(Caenorhabditis elegans)
Secernentea ZK973.11 36
  • 47.25 (n)
  • 33.24 (a)
ZK973.11 37
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EUG1 37
  • 13 (a)
PDI1 37
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10269 37
  • 32 (a)
Species with no ortholog for TMX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMX3 Gene

Gene Tree for TMX3 (if available)
Gene Tree for TMX3 (if available)

Paralogs for TMX3 Gene

Paralogs for TMX3 Gene

genes like me logo Genes that share paralogs with TMX3: view

Variants for TMX3 Gene

Sequence variations from dbSNP and Humsavar for TMX3 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs167443 -- 68,684,944(+) TGGCC(A/G)TTGAC intron-variant
rs167444 -- 68,694,608(-) cttgc(A/G)cccac intron-variant
rs172630 -- 68,691,887(-) TCAAA(A/G)TAAGT intron-variant
rs177919 -- 68,686,139(+) GCGTC(A/G)GGAGG intron-variant
rs177920 -- 68,704,445(-) TCCTG(A/T)TTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMX3 Gene

Variant ID Type Subtype PubMed ID
nsv458117 CNV Gain 19166990
esv847 CNV CNV 17122850
dgv1044e1 CNV Complex 17122850
dgv3446n71 CNV Gain 21882294

Relevant External Links for TMX3 Gene

HapMap Linkage Disequilibrium report

Disorders for TMX3 Gene

(1) University of Copenhagen DISEASES for TMX3 Gene

Relevant External Links for TMX3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TMX3: view

No data available for UniProtKB/Swiss-Prot for TMX3 Gene

Publications for TMX3 Gene

  1. Identification and characterization of a novel thioredoxin-related transmembrane protein of the endoplasmic reticulum. (PMID: 15623505) Haugstetter J. … Ellgaard L. (J. Biol. Chem. 2005) 2 3 4 23
  2. A male with unilateral microphthalmia reveals a role for TMX3 in eye development. (PMID: 20485507) Chao R. … Slavotinek A. (PLoS ONE 2010) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 49

Products for TMX3 Gene

Sources for TMX3 Gene

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