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Aliases for TMX2 Gene

Aliases for TMX2 Gene

  • Thioredoxin-Related Transmembrane Protein 2 2 3
  • Cell Proliferation-Inducing Gene 26 Protein 3 4
  • Thioredoxin Domain-Containing Protein 14 3 4
  • TXNDC14 3 4
  • Protein Disulfide Isomerase Family A, Member 12 3
  • Protein Disulfide Isomerase Family A 2
  • Thioredoxin Domain Containing 14 2
  • Growth-Inhibiting Gene 11 3
  • Member 12 2
  • CGI-31 3
  • PDIA12 3
  • PIG26 3

External Ids for TMX2 Gene

Previous Symbols for TMX2 Gene

  • TXNDC14

Summaries for TMX2 Gene

GeneCards Summary for TMX2 Gene

TMX2 is a Protein Coding gene. An important paralog of this gene is TMX2-CTNND1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMX2 Gene

Genomics for TMX2 Gene

Genomic Location for TMX2 Gene

Start:
57,712,523 bp from pter
End:
57,740,973 bp from pter
Size:
28,451 bases
Orientation:
Plus strand

Genomic View for TMX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMX2 Gene

Regulatory Elements for TMX2 Gene

Proteins for TMX2 Gene

  • Protein details for TMX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y320-TMX2_HUMAN
    Recommended name:
    Thioredoxin-related transmembrane protein 2
    Protein Accession:
    Q9Y320
    Secondary Accessions:
    • B7Z4R4
    • Q53G73
    • Q561W0
    • Q5J7Q7
    • Q8NBP9
    • Q9H3L1

    Protein attributes for TMX2 Gene

    Size:
    296 amino acids
    Molecular mass:
    34038 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG43122.1; Type=Frameshift; Positions=283; Evidence={ECO:0000305}; Sequence=BAC11569.1; Type=Frameshift; Positions=282; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TMX2 Gene

    Alternative splice isoforms for TMX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMX2 Gene

Proteomics data for TMX2 Gene at MOPED

Post-translational modifications for TMX2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys215

No data available for DME Specific Peptides for TMX2 Gene

Domains for TMX2 Gene

Gene Families for TMX2 Gene

HGNC:
  • PDI :Protein disulfide isomerases

Protein Domains for TMX2 Gene

Suggested Antigen Peptide Sequences for TMX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y320

UniProtKB/Swiss-Prot:

TMX2_HUMAN
Domain:
  • The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity.:
    • Q9Y320
  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.:
    • Q9Y320
  • Contains 1 thioredoxin domain.:
    • Q9Y320
genes like me logo Genes that share domains with TMX2: view

Function for TMX2 Gene

Gene Ontology (GO) - Molecular Function for TMX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMX2: view

miRNA for TMX2 Gene

miRTarBase miRNAs that target TMX2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMX2 Gene

Localization for TMX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMX2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMX2 Gene COMPARTMENTS Subcellular localization image for TMX2 gene
Compartment Confidence
endoplasmic reticulum 2
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMX2: view

Pathways for TMX2 Gene

SuperPathways for TMX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with TMX2: view

No data available for Pathways by source for TMX2 Gene

Transcripts for TMX2 Gene

Unigene Clusters for TMX2 Gene

Thioredoxin-related transmembrane protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMX2 Gene

No ASD Table

Relevant External Links for TMX2 Gene

GeneLoc Exon Structure for
TMX2
ECgene alternative splicing isoforms for
TMX2

Expression for TMX2 Gene

mRNA expression in normal human tissues for TMX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMX2 Gene

SOURCE GeneReport for Unigene cluster for TMX2 Gene Hs.654965

mRNA Expression by UniProt/SwissProt for TMX2 Gene

Q9Y320-TMX2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with TMX2: view

No data available for mRNA differential expression in normal tissues for TMX2 Gene

Orthologs for TMX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMX2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMX2 35
  • 88.63 (n)
  • 93.33 (a)
TMX2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMX2 35
  • 90.54 (n)
  • 96.28 (a)
TMX2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5499 36
  • 93 (a)
OneToMany
Tmx2 35
  • 87.8 (n)
  • 92.88 (a)
Tmx2 16
Tmx2 36
  • 93 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmx2 35
  • 88.25 (n)
  • 93.56 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 86 (a)
OneToMany
TMX2 35
  • 77.03 (n)
  • 86.15 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.24015 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17694 35
tmx2 35
  • 69.55 (n)
  • 80.14 (a)
zebrafish
(Danio rerio)
Actinopterygii tmx2a 36
  • 63 (a)
ManyToMany
tmx2b 35
  • 68.81 (n)
  • 72.64 (a)
tmx2b 36
  • 70 (a)
ManyToMany
wufa09g10 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009997 35
  • 51.03 (n)
  • 43.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11007 35
  • 51.5 (n)
  • 44.67 (a)
CG11007 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C35D10.10 35
  • 47.71 (n)
  • 38.82 (a)
C35D10.10 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5859 36
  • 43 (a)
OneToMany
Species with no ortholog for TMX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMX2 Gene

ENSEMBL:
Gene Tree for TMX2 (if available)
TreeFam:
Gene Tree for TMX2 (if available)

Paralogs for TMX2 Gene

Paralogs for TMX2 Gene

Selected SIMAP similar genes for TMX2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for TMX2 Gene

genes like me logo Genes that share paralogs with TMX2: view

Variants for TMX2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMX2 Gene

Variant ID Type Subtype PubMed ID
nsv832163 CNV Gain 17160897
nsv832164 CNV Loss 17160897
nsv508633 CNV Loss 20534489
nsv326 CNV Insertion 18451855
esv2668702 CNV Deletion 23128226

Relevant External Links for TMX2 Gene

HapMap Linkage Disequilibrium report
TMX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TMX2 Gene

Disorders for TMX2 Gene

No disorders were found for TMX2 Gene.

No data available for UniProtKB/Swiss-Prot for TMX2 Gene

Publications for TMX2 Gene

  1. Cloning and identification of a novel cDNA coding thioredoxin-related transmembrane protein 2. (PMID: 12670024) Meng X. … Mao Y. (Biochem. Genet. 2003) 2 3 4 23
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TMX2 Gene

Sources for TMX2 Gene

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