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TMX2 Gene

protein-coding   GIFtS: 47
GCID: GC11P057485

Thioredoxin-Related Transmembrane Protein 2

(Previous name: thioredoxin domain containing 14)
(Previous symbol: TXNDC14)
  Search for TMX2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thioredoxin-Related Transmembrane Protein 21 2     Thioredoxin Domain Containing 141
TXNDC141 2 3     PDIA122
Cell Proliferation-Inducing Gene 26 Protein2 3     PIG262
Thioredoxin Domain-Containing Protein 142 3     Growth-Inhibiting Gene 112
Member 121     Protein Disulfide Isomerase Family A, Member 122
Protein Disulfide Isomerase Family A1     

External Ids:    HGNC: 307391   Entrez Gene: 510752   Ensembl: ENSG000002135937   UniProtKB: Q9Y3203   

Export aliases for TMX2 gene to outside databases

Previous GC identifers: GC11P057255 GC11P057236 GC11P057480 GC11P053828


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMX2 Gene:
TMX2 (thioredoxin-related transmembrane protein 2) is a protein-coding gene. An important paralog of this gene is TMX2-CTNND1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMX2 gene promoter:
         HOXA9B   HOXA9   C/EBPbeta   POU2F1   Brachyury   POU2F1a   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMX2 promoter sequence
   Search Chromatin IP Primers for TMX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11cen-q22.3   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

TMX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMX2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P057485:  view genomic region     (about GC identifiers)

Start:
57,479,995 bp from pter      End:
57,508,445 bp from pter
Size:
28,451 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TMX2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TMX2_HUMAN, Q9Y320 (See protein sequence)
Recommended Name: Thioredoxin-related transmembrane protein 2 precursor  
Size: 296 amino acids; 34038 Da
Sequence caution: Sequence=AAG43122.1; Type=Frameshift; Positions=283; Sequence=BAC11569.1; Type=Frameshift;
Positions=282;
1 PDB 3D structure from and Proteopedia for TMX2:
2DJ0 (3D)    
Secondary accessions: B7Z4R4 Q53G73 Q561W0 Q5J7Q7 Q8NBP9 Q9H3L1
Alternative splicing: 2 isoforms:  Q9Y320-1   Q9Y320-2   

Explore the universe of human proteins at neXtProt for TMX2: NX_Q9Y320

Explore proteomics data for TMX2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys215
  • Modification sites at PhosphoSitePlus

  • See TMX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137484.1  NP_057043.1  

    ENSEMBL proteins: 
     ENSP00000437257   ENSP00000367562   ENSP00000436013   ENSP00000278422   ENSP00000431695  
     ENSP00000434002   ENSP00000431333   ENSP00000437023  

    TMX2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for TMX2
    Cloud-Clone Corp. CLIAs for TMX2
    Search eBioscience for ELISAs for TMX2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PDI: Protein disulfide isomerases

    2 InterPro protein domains:
     IPR013766 Thioredoxin_domain
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9Y320

    ProtoNet protein and cluster: Q9Y320

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TMX2_HUMAN, Q9Y320
    Domain: The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity
    (By similarity)
    Domain: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By
    similarity)
    Similarity: Contains 1 thioredoxin domain


    Find genes that share domains with TMX2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with TMX2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMX2
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    miRNA
    Products:
        
    miRTarBase miRNAs that target TMX2:
    hsa-mir-296-3p (MIRT038472), hsa-let-7a-5p (MIRT052549), hsa-mir-196a-5p (MIRT048152)

    Block miRNA regulation of human, mouse, rat TMX2 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidTMX2 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): TMX2 (NM_001144012)
    Sino Biological Human cDNA Clone for TMX2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMX2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMX2_HUMAN, Q9Y320: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum2
    cytosol1
    extracellular1
    golgi apparatus1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMX2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMX2
    Interactions:

        Search GeneGlobe Interaction Network for TMX2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for TMX2 (Q9Y3202, 3 ENSP000002784224) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COMMD8Q9NX082, 3, ENSP000003709844MINT-8252637 I2D: score=2 STRING: ENSP00000370984
    TMX1Q9H3N12MINT-8374553 MINT-8374574 MINT-8379200
    TMX3Q96JJ72MINT-8374553 MINT-8374574 MINT-8379200
    CANXP278242MINT-8374574 MINT-8379200
    TMX4Q9H1E52MINT-8374574
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0045454cell redox homeostasis IEA--

    Find genes that share ontologies with TMX2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMX2 gene (2 alternative transcripts): 
    NM_001144012.2  NM_015959.3  

    Unigene Cluster for TMX2:

    Thioredoxin-related transmembrane protein 2
    Hs.654965  [show with all ESTs]
    Unigene Representative Sequence: NR_026593
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524972 ENST00000378312(uc001nle.2 uc021qji.1) ENST00000530114
    ENST00000278422(uc001nlc.2) ENST00000525035 ENST00000533602 ENST00000528110
    ENST00000529403(uc001nld.2) ENST00000528042
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMX2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TMX2
    SwitchGear 3'UTR luciferase reporter plasmidTMX2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TMX2
    Predesigned siRNA for gene silencing in human, mouse, rat TMX2
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    GenScript: all cDNA clones in your preferred vector (see all 2): TMX2 (NM_001144012)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMX2
    Primer
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    OriGene qPCR primer pairs and template standards for TMX2
    OriGene qSTAR qPCR primer pairs in human, mouse for TMX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMX2
      QuantiTect SYBR Green Assays in human, mouse, rat TMX2
      QuantiFast Probe-based Assays in human, mouse, rat TMX2

    Additional mRNA sequence: 

    AF059753.1 AF132965.1 AK075359.1 AK223058.1 AK297688.1 AK298065.1 AK312990.1 AY358501.1 
    AY451236.1 AY451237.1 BC000666.1 BC093062.1 NR_026593.2 NR_037645.1 

    Selected DOTS entries (see all 30):

    DT.100891177  DT.100891145  DT.101985367  DT.420489  DT.91767737  DT.100891139  DT.100891163  DT.120747298 
    DT.120747269  DT.91767741  DT.120747255  DT.101966061  DT.95174012  DT.100699566  DT.100834355  DT.102843832 
    DT.120747330  DT.121192619  DT.75172358  DT.95174013  DT.95312316  DT.100843726  DT.100891162  DT.120747311 

    Selected AceView cDNA sequences (see all 274):

    BQ883606 BM555220 BQ687916 BE278811 CB105393 AA526924 R84899 CD654713 
    CR595701 BU656647 CR604249 AA663480 BI771847 BF526515 CR602703 BU541569 
    AA812884 BM767335 AW089141 BG675692 AW150597 BM767264 BI518324 AW083205 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTCTGTG
    TMX2 Expression
    About this image


    TMX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Brain (Nervous System)
             Medulla Oblongata
     
     Lung (Respiratory System)
     
     Spinal Cord (Nervous System)
    TMX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654965

    UniProtKB/Swiss-Prot: TMX2_HUMAN, Q9Y320
    Tissue specificity: Widely expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMX2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmx21 , 5 thioredoxin-related transmembrane protein 21, 5 87.8(n)1
    92.88(a)1
      2 (49.45 cM)5
    669581  NM_025868.31  NP_080144.11 
     846713165 
    chicken
    (Gallus gallus)
    Aves TMX21 thioredoxin-related transmembrane protein 2 77.03(n)
    86.15(a)
      428853  XM_426410.4  XP_426410.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    87(a)
    1 → many
    1(91508962-91520161)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.240152 Xenopus laevis transcribed sequence with moderate similarity more 74.95(n)    CA982350.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa09g102 wufa09g10 75.79(n)   334925  BU709995.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG110071 CG11007 51.5(n)
    44.67(a)
      37249  NM_137585.4  NP_611429.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C35D10.101 C35D10.10 47.71(n)
    38.82(a)
      175646  NM_065611.4  NP_498012.1 


    ENSEMBL Gene Tree for TMX2 (if available)
    TreeFam Gene Tree for TMX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMX2 gene
    TMX2-CTNND12  
    1 SIMAP similar gene for TMX2 using alignment to 5 protein entries:     TMX2_HUMAN (see all proteins):
    TMX2-CTNND1

    Find genes that share paralogs with TMX2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TMX2
    PGOHUM00000260500


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TMX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668702CNV Deletion23128226
    nsv326CNV Insertion18451855
    nsv832164CNV Loss17160897
    nsv508633CNV Loss20534489
    nsv832163CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMX2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with TMX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and identification of a novel cDNA coding thioredoxin-related transmembrane protein 2. (PubMed id 12670024)1, 2, 3, 9 Meng X.... Mao Y. (Biochem. Genet. 2003)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    5. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Palmitoylated TMX and calnexin target to the mitochondria-associated membrane. (PubMed id 22045338)1 Lynes E.M....Simmen T. (EMBO J. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51075 HGNC: 30739 AceView: CTNND1andTMX2andC11orf31 Ensembl:ENSG00000213593 euGenes: HUgn51075
    ECgene: TMX2 H-InvDB: TMX2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMX2 gene:
    Search GeneIP for patents involving TMX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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