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Aliases for TMX2 Gene

Aliases for TMX2 Gene

  • Thioredoxin-Related Transmembrane Protein 2 2 3
  • Cell Proliferation-Inducing Gene 26 Protein 3 4
  • Thioredoxin Domain-Containing Protein 14 3 4
  • TXNDC14 3 4
  • Protein Disulfide Isomerase Family A, Member 12 3
  • Protein Disulfide Isomerase Family A 2
  • Thioredoxin Domain Containing 14 2
  • Growth-Inhibiting Gene 11 3
  • Member 12 2
  • CGI-31 3
  • PDIA12 3
  • PIG26 3

External Ids for TMX2 Gene

Previous HGNC Symbols for TMX2 Gene

  • TXNDC14

Previous GeneCards Identifiers for TMX2 Gene

  • GC11P057255
  • GC11P057236
  • GC11P057480
  • GC11P053828
  • GC11P057485

Summaries for TMX2 Gene

GeneCards Summary for TMX2 Gene

TMX2 (Thioredoxin-Related Transmembrane Protein 2) is a Protein Coding gene. An important paralog of this gene is TMX2-CTNND1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMX2 Gene

Genomics for TMX2 Gene

Regulatory Elements for TMX2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMX2 Gene

Chromosome:
11
Start:
57,712,523 bp from pter
End:
57,740,973 bp from pter
Size:
28,451 bases
Orientation:
Plus strand

Genomic View for TMX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMX2 Gene

Proteins for TMX2 Gene

  • Protein details for TMX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y320-TMX2_HUMAN
    Recommended name:
    Thioredoxin-related transmembrane protein 2
    Protein Accession:
    Q9Y320
    Secondary Accessions:
    • B7Z4R4
    • Q53G73
    • Q561W0
    • Q5J7Q7
    • Q8NBP9
    • Q9H3L1

    Protein attributes for TMX2 Gene

    Size:
    296 amino acids
    Molecular mass:
    34038 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG43122.1; Type=Frameshift; Positions=283; Evidence={ECO:0000305}; Sequence=BAC11569.1; Type=Frameshift; Positions=282; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TMX2 Gene

    Alternative splice isoforms for TMX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMX2 Gene

Proteomics data for TMX2 Gene at MOPED

Post-translational modifications for TMX2 Gene

  • Ubiquitination at Lys 215
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMX2 Gene

Domains & Families for TMX2 Gene

Gene Families for TMX2 Gene

Protein Domains for TMX2 Gene

Suggested Antigen Peptide Sequences for TMX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y320

UniProtKB/Swiss-Prot:

TMX2_HUMAN :
  • The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity.
Domain:
  • The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity.
  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
  • Contains 1 thioredoxin domain.
genes like me logo Genes that share domains with TMX2: view

Function for TMX2 Gene

Gene Ontology (GO) - Molecular Function for TMX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMX2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMX2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for TMX2 Gene

Localization for TMX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMX2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMX2 Gene COMPARTMENTS Subcellular localization image for TMX2 gene
Compartment Confidence
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005623 cell IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMX2: view

Pathways & Interactions for TMX2 Gene

SuperPathways for TMX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with TMX2: view

No data available for Pathways by source and SIGNOR curated interactions for TMX2 Gene

Drugs & Compounds for TMX2 Gene

No Compound Related Data Available

Transcripts for TMX2 Gene

Unigene Clusters for TMX2 Gene

Thioredoxin-related transmembrane protein 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMX2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMX2 Gene

No ASD Table

Relevant External Links for TMX2 Gene

GeneLoc Exon Structure for
TMX2
ECgene alternative splicing isoforms for
TMX2

Expression for TMX2 Gene

mRNA expression in normal human tissues for TMX2 Gene

Protein differential expression in normal tissues from HIPED for TMX2 Gene

This gene is overexpressed in Bone (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMX2 Gene



SOURCE GeneReport for Unigene cluster for TMX2 Gene Hs.654965

mRNA Expression by UniProt/SwissProt for TMX2 Gene

Q9Y320-TMX2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with TMX2: view

Protein tissue co-expression partners for TMX2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TMX2 Gene

Orthologs for TMX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMX2 35
  • 88.63 (n)
  • 93.33 (a)
TMX2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMX2 35
  • 90.54 (n)
  • 96.28 (a)
TMX2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmx2 35
  • 87.8 (n)
  • 92.88 (a)
Tmx2 16
Gm5499 36
  • 93 (a)
OneToMany
Tmx2 36
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmx2 35
  • 88.25 (n)
  • 93.56 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TMX2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMX2 35
  • 77.03 (n)
  • 86.15 (a)
-- 36
  • 86 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17694 35
tmx2 35
  • 69.55 (n)
  • 80.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24015 35
zebrafish
(Danio rerio)
Actinopterygii tmx2b 35
  • 68.81 (n)
  • 72.64 (a)
wufa09g10 35
tmx2a 36
  • 63 (a)
ManyToMany
tmx2b 36
  • 70 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009997 35
  • 51.03 (n)
  • 43.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11007 35
  • 51.5 (n)
  • 44.67 (a)
CG11007 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C35D10.10 35
  • 47.71 (n)
  • 38.82 (a)
C35D10.10 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5859 36
  • 43 (a)
OneToMany
Species with no ortholog for TMX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMX2 Gene

ENSEMBL:
Gene Tree for TMX2 (if available)
TreeFam:
Gene Tree for TMX2 (if available)

Paralogs for TMX2 Gene

Paralogs for TMX2 Gene

(1) SIMAP similar genes for TMX2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for TMX2 Gene

genes like me logo Genes that share paralogs with TMX2: view

Variants for TMX2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMX2 Gene

Variant ID Type Subtype PubMed ID
nsv832163 CNV Gain 17160897
nsv832164 CNV Loss 17160897
nsv508633 CNV Loss 20534489
nsv326 CNV Insertion 18451855
esv2668702 CNV Deletion 23128226

Variation tolerance for TMX2 Gene

Residual Variation Intolerance Score: 63.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMX2 Gene

HapMap Linkage Disequilibrium report
TMX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TMX2 Gene

Disorders for TMX2 Gene

Relevant External Links for TMX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMX2
genes like me logo Genes that share disorders with TMX2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMX2 Gene

Publications for TMX2 Gene

  1. Cloning and identification of a novel cDNA coding thioredoxin-related transmembrane protein 2. (PMID: 12670024) Meng X. … Mao Y. (Biochem. Genet. 2003) 2 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 67

Products for TMX2 Gene

Sources for TMX2 Gene

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