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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMX2 Gene

protein-coding   GIFtS: 45
GCID: GC11P057480

Thioredoxin-Related Transmembrane Protein 2

(Previous name: thioredoxin domain containing 14)
(Previous symbol: TXNDC14)
  Search for TMX2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Thioredoxin-Related Transmembrane Protein 21 2     Thioredoxin Domain Containing 141
TXNDC141 2 3     PDIA122
Cell Proliferation-Inducing Gene 26 Protein2 3     PIG262
Thioredoxin Domain-Containing Protein 142 3     Growth-Inhibiting Gene 112
Member 121     Protein Disulfide Isomerase Family A, Member 122
Protein Disulfide Isomerase Family A1     

External Ids:    HGNC: 307391   Entrez Gene: 510752   Ensembl: ENSG000002135937   UniProtKB: Q9Y3203   
ORGUL members:    fRNAdb10:FR039606      
H-InvDB12:HIT000246318    
NCBI13:AJ276249    
NONCODE14:n407174 n410503 n410504      
RNAdb15:HIV1654    

Export aliases for TMX2 gene to outside databases

Previous GC identifers: GC11P057255 GC11P057236 GC11P053828


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMX2 Gene: 
TMX2 (thioredoxin-related transmembrane protein 2) is a protein-coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include molecular_function. An important paralog of this gene is TMX2-CTNND1.

fRNAdb sequence ontology for TMX2:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for TMX2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMX2 gene promoter:
         HOXA9B   HOXA9   C/EBPbeta   POU2F1   Brachyury   POU2F1a   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11cen-q22.3   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

TMX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMX2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P057480:  view genomic region     (about GC identifiers)

Start:
57,479,995 bp from pter      End:
57,508,445 bp from pter
Size:
28,451 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TMX2

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMX2_HUMAN, Q9Y320 (See protein sequence)
Recommended Name: Thioredoxin-related transmembrane protein 2 precursor  
Size: 296 amino acids; 34038 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAG43122.1; Type=Frameshift; Positions=283; Sequence=BAC11569.1; Type=Frameshift;
Positions=282;
1 PDB 3D structure from and Proteopedia for TMX2:
2DJ0 (3D)    
Secondary accessions: B7Z4R4 Q53G73 Q561W0 Q5J7Q7 Q8NBP9 Q9H3L1
Alternative splicing: 2 isoforms:  Q9Y320-1   Q9Y320-2   

Explore the universe of human proteins at neXtProt for TMX2: NX_Q9Y320

Explore proteomics data for TMX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y320

  • TMX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMX2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001137484.1  NP_057043.1  

    ENSEMBL proteins: 
     ENSP00000437257   ENSP00000367562   ENSP00000436013   ENSP00000278422   ENSP00000431695  
     ENSP00000434002   ENSP00000431333   ENSP00000437023  

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    Cloud-Clone Corp. Proteins for TMX2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0016021integral to membrane IEA--

    TMX2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PDI: Protein disulfide isomerases

    2 InterPro protein domains:
     IPR013766 Thioredoxin_domain
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9Y320

    ProtoNet protein and cluster: Q9Y320

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TMX2_HUMAN, Q9Y320
    Domain: The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity
    (By similarity)
    Domain: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By
    similarity)
    Similarity: Contains 1 thioredoxin domain


    TMX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    TMX2 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMX2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/8 Interacting proteins for TMX2 (Q9Y3202, 3 ENSP000002784224) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COMMD8Q9NX082, 3, ENSP000003709844MINT-8252637 I2D: score=2 STRING: ENSP00000370984
    TMX1Q9H3N12MINT-8374553 MINT-8374574 MINT-8379200
    TMX3Q96JJ72MINT-8374553 MINT-8374574 MINT-8379200
    CANXP278242MINT-8374574 MINT-8379200
    TMX4Q9H1E52MINT-8374574
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0045454cell redox homeostasis IEA--

    TMX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMX2

    Search CenterWatch for drugs/clinical trials and news about TMX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for TMX2 gene (2 alternative transcripts): 
    NM_001144012.2  NM_015959.3  

    Unigene Cluster for TMX2:

    Thioredoxin-related transmembrane protein 2
    Hs.654965  [show with all ESTs]
    Unigene Representative Sequence: NR_026593
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524972 ENST00000378312(uc001nle.2 uc021qji.1) ENST00000530114
    ENST00000278422(uc001nlc.2) ENST00000525035 ENST00000533602 ENST00000528110
    ENST00000529403(uc001nld.2) ENST00000528042
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF059753.1 AF132965.1 AK075359.1 AK223058.1 AK297688.1 AK298065.1 AK312990.1 AY358501.1 
    AY451236.1 AY451237.1 BC000666.1 BC093062.1 NR_026593.2 NR_037645.1 

    24/30 DOTS entries (see all 30):

    DT.100891177  DT.100891145  DT.101985367  DT.420489  DT.91767737  DT.100891139  DT.100891163  DT.120747298 
    DT.120747269  DT.91767741  DT.120747255  DT.101966061  DT.95174012  DT.100699566  DT.100834355  DT.102843832 
    DT.120747330  DT.121192619  DT.75172358  DT.95174013  DT.95312316  DT.100843726  DT.100891162  DT.120747311 

    24/274 AceView cDNA sequences (see all 274):

    AA479983 BF526515 CR625628 BM747066 BI771847 CN482544 AA526924 BU146627 
    CR595161 BX951058 BQ899100 BI223383 BU543593 BM829431 BQ687961 AA774150 
    AA468649 BE142538 BF942189 CR594873 T58545 AI862987 BG754025 AI659292 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMX2 expression in normal human tissues (normalized intensities)      TMX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTCTGTG
    TMX2 Expression
    About this image


    TMX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Medulla Oblongata
             ganglion/cranial/facial VII   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Lung (Respiratory System)

    See TMX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMX2

    SOURCE GeneReport for Unigene cluster: Hs.654965

    UniProtKB/Swiss-Prot: TMX2_HUMAN, Q9Y320
    Tissue specificity: Widely expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMX2 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmx21 , 5 thioredoxin-related transmembrane protein 21, 5 87.8(n)1
    92.88(a)1
      2 (49.45 cM)5
    669581  NM_025868.31  NP_080144.11 
     846713165 
    chicken
    (Gallus gallus)
    Aves TMX21 thioredoxin-related transmembrane protein 2 77.03(n)
    86.15(a)
      428853  XM_426410.3  XP_426410.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    87(a)
    1 → many
    1(91508962-91520161)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.240152 Xenopus laevis transcribed sequence with moderate similarity more 74.95(n)    CA982350.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa09g102 wufa09g10 75.79(n)   334925  BU709995.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG110071 CG11007 51.5(n)
    44.67(a)
      37249  NM_137585.3  NP_611429.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C35D10.101 Protein C35D10.10 47.58(n)
    38.82(a)
      175646  NM_065611.3  NP_498012.1 


    ENSEMBL Gene Tree for TMX2 (if available)
    TreeFam Gene Tree for TMX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMX2 gene
    TMX2-CTNND12  
    1 SIMAP similar gene for TMX2 using alignment to 5 protein entries:     TMX2_HUMAN (see all proteins):
    TMX2-CTNND1

    TMX2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TMX2
    PGOHUM00000260500


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TMX2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2668702CNV Deletion23128226
    nsv326CNV Insertion18451855
    nsv832164CNV Loss17160897
    nsv508633CNV Loss20534489
    nsv832163CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TMX2 for disorders           About MalaCards
    OMIM information: 194071 604499 607967 609270 609470 607914    

    TMX2 for disorders           About GeneDecksing


    Export disorders for TMX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMX2 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with TMX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and identification of a novel cDNA coding thioredoxin-related transmembrane protein 2. (PubMed id 12670024)1, 2, 3, 9 Meng X....Mao Y. (2003)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    5. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Palmitoylated TMX and calnexin target to the mitochond ria-associated membrane. (PubMed id 22045338)1 Lynes E.M....Simmen T. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51075 HGNC: 30739 AceView: CTNND1andTMX2andC11orf31 Ensembl:ENSG00000213593 euGenes: HUgn51075
    ECgene: TMX2 H-InvDB: TMX2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMX2 gene:
    Search GeneIP for patents involving TMX2

    GeneCards and IP:
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