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TMX1 Gene

protein-coding   GIFtS: 53
GCID: GC14P051706

Thioredoxin-Related Transmembrane Protein 1

(Previous names: thioredoxin domain-containing, thioredoxin domain containing,...)
(Previous symbols: TXNDC, TXNDC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thioredoxin-Related Transmembrane Protein 11 2     Member 111
TXNDC11 2 3 5     Protein Disulfide Isomerase Family A1
TXNDC1 2 3     Thioredoxin Domain Containing1
TMX2 3 5     Thioredoxin Domain-Containing1
Thioredoxin Domain Containing 11 2     Thioredoxin-Related Transmembrane Protein1
Thioredoxin Domain-Containing Protein 12 3     PDIA112
Transmembrane Trx-Related Protein2 3     Protein Disulfide Isomerase Family A, Member 112

External Ids:    HGNC: 154871   Entrez Gene: 815422   Ensembl: ENSG000001399217   OMIM: 6105275   UniProtKB: Q9H3N13   

Export aliases for TMX1 gene to outside databases

Previous GC identifers: GC14P050779 GC14P031866


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMX1 Gene:
TXNDC1 is a thioredoxin (TXN; see MIM 187700)-related protein with disulfide reductase activity (Matsuo et al.,
2001 (PubMed 11152479)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TMX1 Gene:
TMX1 (thioredoxin-related transmembrane protein 1) is a protein-coding gene. Diseases associated with TMX1 include hepatocellular carcinoma, and malaria. GO annotations related to this gene include disulfide oxidoreductase activity and arsenate reductase (thioredoxin) activity. An important paralog of this gene is TMX4.

UniProtKB/Swiss-Prot: TMX1_HUMAN, Q9H3N1
Function: May participate in various redox reactions through the reversible oxidation of its active center dithiol
to a disulfide and catalyze dithiol-disulfide exchange reactions

Gene Wiki entry for TMX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMX1 gene promoter:
         E2F-3a   E2F-4   E2F-5   AML1a   E2F-2   C/EBPalpha   MZF-1   S8   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMX1 promoter sequence
   Search Chromatin IP Primers for TMX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q22.1

TMX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMX1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P051706:  view genomic region     (about GC identifiers)

Start:
51,706,880 bp from pter      End:
51,724,373 bp from pter
Size:
17,494 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TMX1_HUMAN, Q9H3N1 (See protein sequence)
Recommended Name: Thioredoxin-related transmembrane protein 1 precursor  
Size: 280 amino acids; 31791 Da
1 PDB 3D structure from and Proteopedia for TMX1:
1X5E (3D)    
Secondary accessions: B2R7A4 Q8N487 Q8NBN5 Q9Y4T6

Explore the universe of human proteins at neXtProt for TMX1: NX_Q9H3N1

Explore proteomics data for TMX1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys107, Lys121, Lys130
  • Modification sites at PhosphoSitePlus

  • See TMX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_110382.3  
    ENSEMBL proteins: 
     ENSP00000393316   ENSP00000451585  

    TMX1 Human Recombinant Protein Products:

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    Novus Biologicals TMX1 Protein
    Novus Biologicals TMX1 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for TMX1

    TMX1 Antibody Products:

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    TMX1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMX1
    Cloud-Clone Corp. CLIAs for TMX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PDI: Protein disulfide isomerases

    3 InterPro protein domains:
     IPR013766 Thioredoxin_domain
     IPR017937 Thioredoxin_CS
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9H3N1

    ProtoNet protein and cluster: Q9H3N1

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TMX1_HUMAN, Q9H3N1
    Similarity: Contains 1 thioredoxin domain


    TMX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMX1_HUMAN, Q9H3N1
    Function: May participate in various redox reactions through the reversible oxidation of its active center dithiol
    to a disulfide and catalyze dithiol-disulfide exchange reactions

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003756protein disulfide isomerase activity IBA--
    GO:0015036disulfide oxidoreductase activity IDA11152479
    GO:0030612arsenate reductase (thioredoxin) activity ----
         
    TMX1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Tmx1 (no phenotypes)

    TMX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tmx1tm1Lex for TMX1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMX1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMX1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMX1:
    hsa-mir-1 (MIRT005279)

    Block miRNA regulation of human, mouse, rat TMX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMX1 (see all 43):
    hsa-miR-323-3p hsa-miR-520f hsa-miR-875-5p hsa-miR-128 hsa-miR-578 hsa-miR-218 hsa-miR-105 hsa-miR-1273d
    SwitchGear 3'UTR luciferase reporter plasmidTMX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMX1
    Predesigned siRNA for gene silencing in human, mouse, rat TMX1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TMX1

    Clone
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    OriGene clones in human, mouse for TMX1 (see all 6)
    OriGene ORF clones in mouse, rat for TMX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMX1 (NM_030755)
    Sino Biological Human cDNA Clone for TMX1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMX1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TMX1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMX1_HUMAN, Q9H3N1: Membrane; Single-pass type I membrane protein (Potential). Endoplasmic reticulum membrane;
    Single-pass type I membrane protein (Potential). Note=Predominantly found in the endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IDA11152479
    GO:0016021integral component of membrane IEA--

    TMX1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including TMX1: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TMX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TMX1 (Q9H3N12, 3 ENSP000003933164) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CANXP278242MINT-8374764 MINT-8374650 MINT-8374740 MINT-8374574 MINT-8379200
    TMX2Q9Y3202MINT-8374553 MINT-8374574 MINT-8379200
    TMX3Q96JJ72MINT-8374553 MINT-8374574 MINT-8379200
    H2AFXP161043, ENSP000003643104I2D: score=1 STRING: ENSP00000364310
    MCCP235083, ENSP000003862274I2D: score=1 STRING: ENSP00000386227
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    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication ----
    GO:0006457protein folding IBA--
    GO:0006888ER to Golgi vesicle-mediated transport ----
    GO:0006950response to stress ----
    GO:0007165signal transduction ----

    TMX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMX1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMX1 gene: 
    NM_030755.4  

    Unigene Cluster for TMX1:

    Thioredoxin-related transmembrane protein 1
    Hs.125221  [show with all ESTs]
    Unigene Representative Sequence: NM_030755
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555574(uc010tqr.1) ENST00000457354(uc001wza.4 uc010aoa.3)
    ENST00000556683
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMX1 (see all 43):
    hsa-miR-323-3p hsa-miR-520f hsa-miR-875-5p hsa-miR-128 hsa-miR-578 hsa-miR-218 hsa-miR-105 hsa-miR-1273d
    SwitchGear 3'UTR luciferase reporter plasmidTMX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMX1
    Predesigned siRNA for gene silencing in human, mouse, rat TMX1
    Clone
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    OriGene clones in human, mouse for TMX1 (see all 6)
    OriGene ORF clones in mouse, rat for TMX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMX1 (NM_030755)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMX1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMX1
    OriGene qSTAR qPCR primer pairs in human, mouse for TMX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMX1
      QuantiTect SYBR Green Assays in human, mouse, rat TMX1
      QuantiFast Probe-based Assays in human, mouse, rat TMX1

    Additional mRNA sequence: 

    AB048246.1 AK075395.1 AK302416.1 AK303134.1 AK312905.1 AL080080.1 AY358640.1 BC016769.1 
    BC032834.1 BC036460.2 BC050366.1 BC056874.1 

    11 DOTS entries:

    DT.114133  DT.100801339  DT.101983838  DT.204286  DT.95350980  DT.95278192  DT.95278194  DT.100838515 
    DT.120746512  DT.95205556  DT.91955689 

    Selected AceView cDNA sequences (see all 162):

    T25734 AA913737 BM273117 BE122727 BU581211 BM354049 AA732423 AB048246 
    CB128308 AW591101 BG253627 BC056874 BM127467 BX509417 AA620599 BQ897737 
    CK903636 CB152444 BX343708 BE797339 BG702791 BM666099 AI857865 AL080080 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATTCTCTT
    TMX1 Expression
    About this image


    TMX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
    TMX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.125221

    UniProtKB/Swiss-Prot: TMX1_HUMAN, Q9H3N1
    Tissue specificity: Ubiquitous. Highly expressed in kidney, liver, placenta and lung

        Pathway & Disease-focused RT2 Profiler PCR Array including TMX1: 
              Apoptosis 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for TMX1
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    QuantiFast Probe-based Assays in human, mouse, rat TMX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMX1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmx11 , 5 thioredoxin-related transmembrane protein 11, 5 82.31(n)1
    78.08(a)1
      12 (29.13 cM)5
    727361  NM_028339.11  NP_082615.11 
     704530955 
    chicken
    (Gallus gallus)
    Aves TMX16
    thioredoxin-related transmembrane protein 1
    53(a)
    1 ↔ 1
    5(57914585-57916800)
    lizard
    (Anolis carolinensis)
    Reptilia TMX16
    thioredoxin-related transmembrane protein 1
    62(a)
    1 ↔ 1
    GL343274.1(211059-220431)
    African clawed frog
    (Xenopus laevis)
    Amphibia BM004627.12   -- 77.78(n)    BM004627.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056715.12   -- 72.88(n)    BC056715.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55541 CG5554 50(n)
    46.97(a)
      37775  NM_137994.2  NP_611838.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dpy-111 dpy-11 53.64(n)
    47.72(a)
      179040  NM_072254.4  NP_504655.1 


    ENSEMBL Gene Tree for TMX1 (if available)
    TreeFam Gene Tree for TMX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMX1 gene
    TMX42  
    5 SIMAP similar genes for TMX1 using alignment to 2 protein entries:     TMX1_HUMAN (see all proteins):
    TXNDC    TMX4    TMX3    PDIA6    P4HB

    TMX1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TMX1
    PGOHUM00000232662 PGOHUM00000249705


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMX1 (see all 441)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs128807551,2
    C,F--32687862(+) AGAATT/CATCTT 1 -- us2k13Minor allele frequency- C:0.33NA 6
    rs1147416971,2
    C,F--51704905(+) TTCTGA/CACCCC 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1397222031,2
    --51705005(+) GAGGAC/TATGTG 1 -- us2k10--------
    rs1429167391,2
    --51705108(+) GGCCTA/GGAAAG 1 -- us2k10--------
    rs1813757111,2
    --51705223(+) TTAGCC/GTTCCA 1 -- us2k10--------
    rs1511216291,2
    --51705241(+) CAATCA/GGATAT 1 -- us2k10--------
    rs1142919541,2
    C,F--51705356(+) TTTCCT/ATTCAC 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1856974771,2
    --51705493(+) AGTCTC/GAATGA 1 -- us2k10--------
    rs1892395091,2
    C--51705588(+) CGGGGA/GGCAGT 1 -- us2k10--------
    rs802734221,2
    C--51705654(+) TGAGA-/GGAATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMX1 (51706880 - 51724373 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TMX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv274183CNV Insertion20981092
    esv270239CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TMX1
    DNA2.0 Custom Variant and Variant Library Synthesis for TMX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610527    OMIM disorders: --

    2 diseases for TMX1:    
    About MalaCards
    hepatocellular carcinoma    malaria


    TMX1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMX1

    Export disorders for TMX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMX1 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with TMX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel thioredoxin-related transmembrane protein. (PubMed id 11152479)1, 2, 3, 9 Matsuo Y....Kizaka-Kondoh S. (J. Biol. Chem. 2001)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Physical and functional interaction of transmembrane thioredoxin-related protein with major histocompatibility complex class I heavy chain: redox-based protein quality control and its potential relevance to immune responses. (PubMed id 19741092)1, 9 Matsuo Y....Yodoi J. (Mol. Biol. Cell 2009)
    8. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    9. The protective role of the transmembrane thioredoxin-related protein TMX in inflammatory liver injury. (PubMed id 22924822)1 Matsuo Y....Yodoi J. (amp 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81542 HGNC: 15487 AceView: TXNDC Ensembl:ENSG00000139921 euGenes: HUgn81542
    ECgene: TMX1 H-InvDB: TMX1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMX1 gene:
    Search GeneIP for patents involving TMX1

    GeneCards and IP:
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