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Aliases for TMX1 Gene

Aliases for TMX1 Gene

  • Thioredoxin Related Transmembrane Protein 1 2 3
  • Thioredoxin-Related Transmembrane Protein 1 2 5
  • Thioredoxin Domain-Containing Protein 1 3 4
  • Transmembrane Trx-Related Protein 3 4
  • Thioredoxin Domain Containing 1 2 3
  • TXNDC1 3 4
  • TXNDC 3 4
  • TMX 3 4
  • Protein Disulfide Isomerase Family A, Member 11 3
  • Thioredoxin-Related Transmembrane Protein 2
  • Protein Disulfide Isomerase Family A 2
  • Thioredoxin Domain-Containing 2
  • Thioredoxin Domain Containing 2
  • Member 11 2
  • PDIA11 3

External Ids for TMX1 Gene

Previous HGNC Symbols for TMX1 Gene

  • TXNDC1

Previous GeneCards Identifiers for TMX1 Gene

  • GC14P050779
  • GC14P051706
  • GC14P031866

Summaries for TMX1 Gene

Entrez Gene Summary for TMX1 Gene

  • TXNDC1 is a thioredoxin (TXN; see MIM 187700)-related protein with disulfide reductase activity (Matsuo et al., 2001 [PubMed 11152479]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TMX1 Gene

TMX1 (Thioredoxin Related Transmembrane Protein 1) is a Protein Coding gene. GO annotations related to this gene include protein disulfide isomerase activity and disulfide oxidoreductase activity. An important paralog of this gene is TMX4.

UniProtKB/Swiss-Prot for TMX1 Gene

  • May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.

Gene Wiki entry for TMX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMX1 Gene

Genomics for TMX1 Gene

Regulatory Elements for TMX1 Gene

Promoters for TMX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMX1 Gene

51,240,162 bp from pter
51,257,655 bp from pter
17,494 bases
Plus strand

Genomic View for TMX1 Gene

Genes around TMX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMX1 Gene

Proteins for TMX1 Gene

  • Protein details for TMX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin-related transmembrane protein 1
    Protein Accession:
    Secondary Accessions:
    • B2R7A4
    • Q8N487
    • Q8NBN5
    • Q9Y4T6

    Protein attributes for TMX1 Gene

    280 amino acids
    Molecular mass:
    31791 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TMX1 Gene

neXtProt entry for TMX1 Gene

Proteomics data for TMX1 Gene at MOPED

Post-translational modifications for TMX1 Gene

  • Ubiquitination at Lys 107, Lys 121, and Lys 130
  • Modification sites at PhosphoSitePlus

Other Protein References for TMX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TMX1 Gene

Domains & Families for TMX1 Gene

Gene Families for TMX1 Gene

Protein Domains for TMX1 Gene

Suggested Antigen Peptide Sequences for TMX1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 thioredoxin domain.
  • Contains 1 thioredoxin domain.
genes like me logo Genes that share domains with TMX1: view

Function for TMX1 Gene

Molecular function for TMX1 Gene

UniProtKB/Swiss-Prot Function:
May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.

Phenotypes for TMX1 Gene

genes like me logo Genes that share phenotypes with TMX1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMX1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMX1 Gene

Localization for TMX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMX1 Gene

Membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Predominantly found in the endoplasmic reticulum. {ECO:0000269 PubMed:11152479}.

Subcellular locations from

Jensen Localization Image for TMX1 Gene COMPARTMENTS Subcellular localization image for TMX1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
extracellular 3

No data available for Gene Ontology (GO) - Cellular Components for TMX1 Gene

Pathways & Interactions for TMX1 Gene

SuperPathways for TMX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034976 response to endoplasmic reticulum stress IMP 11152479
genes like me logo Genes that share ontologies with TMX1: view

No data available for Pathways by source and SIGNOR curated interactions for TMX1 Gene

Drugs & Compounds for TMX1 Gene

No Compound Related Data Available

Transcripts for TMX1 Gene

mRNA/cDNA for TMX1 Gene

Unigene Clusters for TMX1 Gene

Thioredoxin-related transmembrane protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMX1 Gene

No ASD Table

Relevant External Links for TMX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMX1 Gene

mRNA expression in normal human tissues for TMX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMX1 Gene

This gene is overexpressed in Nasal epithelium (14.4) and Bone (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMX1 Gene

SOURCE GeneReport for Unigene cluster for TMX1 Gene Hs.125221

mRNA Expression by UniProt/SwissProt for TMX1 Gene

Tissue specificity: Ubiquitous. Highly expressed in kidney, liver, placenta and lung.
genes like me logo Genes that share expression patterns with TMX1: view

Protein tissue co-expression partners for TMX1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TMX1 Gene

Orthologs for TMX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMX1 35
  • 90.53 (n)
  • 91.73 (a)
TMX1 36
  • 91 (a)
(Canis familiaris)
Mammalia TMX1 35
  • 91.85 (n)
  • 92.81 (a)
TMX1 36
  • 92 (a)
(Mus musculus)
Mammalia Tmx1 35
  • 82.31 (n)
  • 78.08 (a)
Tmx1 16
Tmx1 36
  • 77 (a)
(Pan troglodytes)
Mammalia TMX1 35
  • 99.17 (n)
  • 98.93 (a)
TMX1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmx1 35
  • 82.95 (n)
  • 80.38 (a)
(Monodelphis domestica)
Mammalia TMX1 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia TMX1 36
  • 77 (a)
(Gallus gallus)
Aves TMX1 36
  • 53 (a)
(Anolis carolinensis)
Reptilia TMX1 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmx1 35
  • 66.8 (n)
  • 65.56 (a)
(Danio rerio)
Actinopterygii tmx1 35
  • 64.1 (n)
  • 65.64 (a)
tmx1 36
  • 51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001613 35
  • 49.5 (n)
  • 45.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5554 35
  • 50 (n)
  • 46.97 (a)
CG5554 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea dpy-11 35
  • 53.64 (n)
  • 47.72 (a)
dpy-11 36
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for TMX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMX1 Gene

Gene Tree for TMX1 (if available)
Gene Tree for TMX1 (if available)

Paralogs for TMX1 Gene

Paralogs for TMX1 Gene

(5) SIMAP similar genes for TMX1 Gene using alignment to 2 proteins: Pseudogenes for TMX1 Gene

genes like me logo Genes that share paralogs with TMX1: view

Variants for TMX1 Gene

Sequence variations from dbSNP and Humsavar for TMX1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs9918 -- 51,255,972(-) CATCC(A/G/T)AACTC utr-variant-3-prime
rs13156 -- 51,255,631(-) TAAAA(A/G)TGTTA utr-variant-3-prime
rs1128841 -- 51,255,409(+) TTTTT(C/T)TTTTT utr-variant-3-prime
rs3088089 -- 51,255,964(-) CTCTT(C/T)AATGG utr-variant-3-prime
rs4261445 -- 51,256,822(+) GGTGA(A/G)TCAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMX1 Gene

Variant ID Type Subtype PubMed ID
esv274183 CNV Insertion 20981092
esv270239 CNV Insertion 20981092

Variation tolerance for TMX1 Gene

Residual Variation Intolerance Score: 16.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMX1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMX1 Gene

Disorders for TMX1 Gene

Relevant External Links for TMX1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMX1 Gene

Publications for TMX1 Gene

  1. Identification of a novel thioredoxin-related transmembrane protein. (PMID: 11152479) Matsuo Y. … Kizaka-Kondoh S. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Physical and functional interaction of transmembrane thioredoxin-related protein with major histocompatibility complex class I heavy chain: redox-based protein quality control and its potential relevance to immune responses. (PMID: 19741092) Matsuo Y. … Yodoi J. (Mol. Biol. Cell 2009) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. The protective role of the transmembrane thioredoxin-related protein TMX in inflammatory liver injury. (PMID: 22924822) Matsuo Y. … Yodoi J. (Antioxid. Redox Signal. 2013) 3

Products for TMX1 Gene

Sources for TMX1 Gene

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