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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMX1 Gene

protein-coding   GIFtS: 49
GCID: GC14P051706

thioredoxin-related transmembrane protein 1

(Previous names: thioredoxin domain-containing, thioredoxin domain containing,...)
(Previous symbols: TXNDC, TXNDC1)
 Explore 2 diseases affiliated with
TMX1 via our new
 Human Malady Compendium 
Biological research products
for TMX1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Thioredoxin-Related Transmembrane Protein 11 2     Thioredoxin Domain-Containing Protein 12 3
TMX1 2 3 5     Transmembrane Trx-Related Protein2 3
TXNDC11 2 3 5     Thioredoxin Domain Containing1
TXNDC1 2 3     Thioredoxin Domain-Containing1
PDIA111 2     Protein Disulfide Isomerase Family A, Member 112
Thioredoxin Domain Containing 11 2     

External Ids:    HGNC: 154871   Entrez Gene: 815422   Ensembl: ENSG000001399217   OMIM: 6105275   UniProtKB: Q9H3N13   

Export aliases for TMX1 gene to outside databases

Previous GC identifers: GC14P050779 GC14P031866


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMX1:
TXNDC1 is a thioredoxin (TXN; see MIM 187700)-related protein with disulfide reductase activity (Matsuo et al., 2001
(PubMed 11152479)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: TMX1_HUMAN, Q9H3N1
Function: May participate in various redox reactions through the reversible oxidation of its active center dithiol to a
disulfide and catalyze dithiol-disulfide exchange reactions

Gene Wiki entry for TMX1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMX1 gene promoter:
         E2F-3a   E2F-4   E2F-5   AML1a   E2F-2   C/EBPalpha   MZF-1   S8   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q22.1

TMX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMX1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P051706:  view genomic region     (about GC identifiers)

Start:
51,706,880 bp from pter      End:
51,724,373 bp from pter
Size:
17,494 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TMX1_HUMAN, Q9H3N1 (See protein sequence)
Recommended Name: Thioredoxin-related transmembrane protein 1 precursor  
Size: 280 amino acids; 31791 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential). Endoplasmic reticulum membrane;
Single-pass type I membrane protein (Potential). Note=Predominantly found in the endoplasmic reticulum
1 PDB 3D structure from and Proteopedia for TMX1:
1X5E (3D)    
Secondary accessions: B2R7A4 Q8N487 Q8NBN5 Q9Y4T6

Explore the universe of human proteins at neXtProt for TMX1: NX_Q9H3N1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H3N1

  • TMX1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_110382.3  
    ENSEMBL proteins: 
     ENSP00000393316   ENSP00000451585  

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    Novus Biologicals TMX1 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TMX1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IDA11152479
    GO:0016021integral to membrane IEA--


    TMX1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TMX1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TMX1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013766 Thioredoxin_domain
     IPR017937 Thioredoxin_CS
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9H3N1

    ProtoNet protein and cluster: Q9H3N1

    1 Blocks protein family: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TMX1_HUMAN, Q9H3N1
    Similarity: Contains 1 thioredoxin domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TMX1_HUMAN, Q9H3N1
    Function: May participate in various redox reactions through the reversible oxidation of its active center dithiol to a
    disulfide and catalyze dithiol-disulfide exchange reactions

    miRNA
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    miRTarBase miRNAs that target TMX1:
    hsa-mir-1 (MIRT005279)

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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMX1
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate TMX1 (see all 43):
    hsa-miR-323-3p hsa-miR-520f hsa-miR-875-5p hsa-miR-128 hsa-miR-578 hsa-miR-218 hsa-miR-105 hsa-miR-1273d
    SwitchGear 3'UTR luciferase reporter plasmidTMX1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMX1 (see all 4)
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    OriGene siRNA: TMX1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMX1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015036disulfide oxidoreductase activity IDA11152479
    GO:0030612arsenate reductase (thioredoxin) activity NAS11152479


    TMX1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Tmx1tm1Lex for TMX1
         1 MGI phenotypic allele for Tmx1 (no phenotypes)

    TMX1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/24 Interacting proteins for TMX1 (Q9H3N12, 3 ENSP000003933164) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CANXP278242MINT-8374764 MINT-8374650 MINT-8374740 MINT-8374574 MINT-8379200
    TMX2Q9Y3202MINT-8374553 MINT-8374574 MINT-8379200
    TMX3Q96JJ72MINT-8374553 MINT-8374574 MINT-8379200
    H2AFXP161043, ENSP000003643104I2D: score=1 STRING: ENSP00000364310
    MCCP235083, ENSP000003862274I2D: score=1 STRING: ENSP00000386227
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication NAS11152479
    GO:0006888ER to Golgi vesicle-mediated transport TAS11152479
    GO:0006950response to stress NAS11152479
    GO:0007165signal transduction NAS11152479
    GO:0008283cell proliferation NAS11152479


    TMX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMX1
    Search CenterWatch for drugs/clinical trials and news about TMX1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMX1 gene: 
    NM_030755.4  

    Unigene Cluster for TMX1:

    Thioredoxin-related transmembrane protein 1
    Hs.125221  [show with all ESTs]
    Unigene Representative Sequence: NM_030755
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555574(uc010tqr.1) ENST00000457354(uc001wza.4 uc010aoa.3)
    ENST00000556683

    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate TMX1 (see all 43):
    hsa-miR-323-3p hsa-miR-520f hsa-miR-875-5p hsa-miR-128 hsa-miR-578 hsa-miR-218 hsa-miR-105 hsa-miR-1273d
    SwitchGear 3'UTR luciferase reporter plasmidTMX1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: TMX1
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMX1

    Additional cDNA sequence: 

    AB048246.1 AK075395.1 AK302416.1 AK303134.1 AK312905.1 AL080080.1 AY358640.1 BC016769.1 
    BC032834.1 BC036460.2 BC050366.1 BC056874.1 

    11 DOTS entries:

    DT.114133  DT.100801339  DT.101983838  DT.204286  DT.95350980  DT.95278192  DT.95278194  DT.100838515 
    DT.120746512  DT.95205556  DT.91955689 

    24/162 AceView cDNA sequences (see all 162):

    T25734 AA913737 BM354049 BU581211 BE122727 BM127467 BC056874 AB048246 
    AA732423 AA620599 BX509417 AW591101 BG253627 BM273117 CB128308 BP432600 
    BM666099 CK903636 BX343707 BC050366 BG778073 BE797339 BM127185 BM557972 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTATTCTCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TMX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMX1

    SOURCE GeneReport for Unigene cluster: Hs.125221

    UniProtKB/Swiss-Prot: TMX1_HUMAN, Q9H3N1
    Tissue specificity: Ubiquitous. Highly expressed in kidney, liver, placenta and lung

        SABiosciences Expression via Pathway-Focused PCR Array including TMX1: 
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMX1 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TMX16
    Uncharacterized protein
    50(a)
    1 ↔ 1
    5(60605530-60621615)
    lizard
    (Anolis carolinensis)
    Reptilia TMX16
    --
    65(a)
    1 ↔ 1
    GL343274.1(211209-220425)
    African clawed frog
    (Xenopus laevis)
    Amphibia BM004627.12   -- 77.78(n)    BM004627.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056715.12   -- 72.88(n)    BC056715.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55541 CG5554 48.75(n)
    43.08(a)
      37775  NM_137994.2  NP_611838.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dpy-111 Protein DPY-11 52.74(n)
    46.95(a)
      179040  NM_072254.3  NP_504655.1 


    ENSEMBL Gene Tree for TMX1 (if available)
    TreeFam Gene Tree for TMX1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMX1 gene
    TMX42  
    5 SIMAP similar genes for TMX1 using alignment to 2 protein entries:     TMX1_HUMAN (see all proteins):
    TXNDC    TMX4    TMX3    PDIA6    P4HB

    TMX1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TMX1
    PGOHUM00000232662 PGOHUM00000249705


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/342 NCBI SNPs in TMX1 are shown (see all 342    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1147416971,2
    C,F,--51704905(+) TTCTGA/CACCCC 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1397222031,2
    --51705005(+) GAGGAC/TATGTG 1 -- us2k10--------
    rs1429167391,2
    --51705108(+) GGCCTA/GGAAAG 1 -- us2k10--------
    rs1813757111,2
    --51705223(+) TTAGCC/GTTCCA 1 -- us2k10--------
    rs1511216291,2
    --51705241(+) CAATCA/GGATAT 1 -- us2k10--------
    rs1142919541,2
    C,F,--51705356(+) TTTCCT/ATTCAC 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1856974771,2
    --51705493(+) AGTCTC/GAATGA 1 -- us2k10--------
    rs1892395091,2
    --51705588(+) CGGGGA/GGCAGT 1 -- us2k10--------
    rs802734221,2
    C,--51705654(+) TGAGA-/GGAATC 1 -- us2k10--------
    rs571344231,2
    C,--51705655(+) GAGAA-/GAATCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMX1 (51706880 - 51724373 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TMX1: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TMX1 for disorders           About GeneDecksing

    OMIM gene information: 610527    OMIM disorders: --

    2 diseases for TMX1:    About MalaCards
    hepatocellular carcinoma    carcinoma


    Export disorders for TMX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMX1 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with TMX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel thioredoxin-related transmembrane protein. (PubMed id 11152479)1, 2, 3, 9 Matsuo Y....Kizaka-Kondoh S. (2001)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Physical and functional interaction of transmembrane thioredoxin-related protein with major histocompatibility complex class I heavy chain: redox-based protein quality control and its potential relevance to immu ne responses. (PubMed id 19741092)1, 9 Matsuo Y....Yodoi J. (2009)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Palmitoylated TMX and calnexin target to the mitochond ria-associated membrane. (PubMed id 22045338)1 Lynes E.M....Simmen T. (2012)
    10. Reductive activation of type 2 ribosome-inactivating p roteins is promoted by transmembrane thioredoxin-related protein. (PubMed id 22228764)1 Pasetto M....Colombatti M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81542 HGNC: 15487 AceView: TXNDC Ensembl:ENSG00000139921 euGenes: HUgn81542
    ECgene: TMX1 H-InvDB: TMX1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMX1 gene:
    Search GeneIP for patents involving TMX1

    GeneCards and IP:
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