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TMUB2 Gene

protein-coding   GIFtS: 50
GCID: GC17P042264

Transmembrane And Ubiquitin-Like Domain Containing 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane And Ubiquitin-Like Domain Containing 21 2
Transmembrane And Ubiquitin-Like Domain-Containing Protein 22

External Ids:    HGNC: 284591   Entrez Gene: 790892   Ensembl: ENSG000001685917   UniProtKB: Q71RG43   

Export aliases for TMUB2 gene to outside databases

Previous GC identifers: GC17P039620 GC17P038028


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMUB2 Gene:
TMUB2 (transmembrane and ubiquitin-like domain containing 2) is a protein-coding gene. An important paralog of this gene is TMUB1.

Gene Wiki entry for TMUB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMUB2 gene promoter:
         E2F-1   Pax-5   Sp1   E2F   E2F-2   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TMUB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMUB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21

TMUB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMUB2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P042264:  view genomic region     (about GC identifiers)

Start:
42,264,338 bp from pter      End:
42,269,099 bp from pter
Size:
4,762 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TMUB2_HUMAN, Q71RG4 (See protein sequence)
Recommended Name: Transmembrane and ubiquitin-like domain-containing protein 2  
Size: 321 amino acids; 33788 Da
Secondary accessions: B3KU81 Q8NDI2 Q9BPZ5 Q9HAG3
Alternative splicing: 4 isoforms:  Q71RG4-1   Q71RG4-2   Q71RG4-3   Q71RG4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMUB2: NX_Q71RG4

Explore proteomics data for TMUB2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys145, Lys179, Lys212
  • Modification sites at PhosphoSitePlus

  • See TMUB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001070142.1  NP_077012.2  NP_803190.2  

    ENSEMBL proteins: 
     ENSP00000413127   ENSP00000444565   ENSP00000466971   ENSP00000465015   ENSP00000313214  
     ENSP00000465217   ENSP00000467364   ENSP00000466189   ENSP00000468765   ENSP00000467960  
     ENSP00000465152   ENSP00000467506   ENSP00000465153   ENSP00000465810   ENSP00000350672  

    TMUB2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TMUB2
    OriGene Protein Over-expression Lysate for TMUB2
    OriGene MassSpec for TMUB2
    OriGene Custom Protein Services for TMUB2
    GenScript Custom Purified and Recombinant Proteins Services for TMUB2
    Novus Biologicals TMUB2 Lysates
    Sino Biological Recombinant Protein for TMUB2
    Sino Biological Cell Lysate for TMUB2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMUB2

     
    Search eBioscience for Proteins for TMUB2 

     
    Search antibodies-online for proteins for TMUB2 

     
    antibodies-online peptides for TMUB2

    TMUB2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals TMUB2 Antibody
    Abcam antibodies for TMUB2
    Cloud-Clone Corp. Antibodies for TMUB2
    ThermoFisher Antibodies for TMUB2
    antibodies-online antibodies for TMUB2 (10 products) 

    TMUB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMUB2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMUB2
    Cloud-Clone Corp. CLIAs for TMUB2
    Search eBioscience for ELISAs for TMUB2 
    antibodies-online kits for TMUB2 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000626 Ubiquitin_dom

    Graphical View of Domain Structure for InterPro Entry Q71RG4

    ProtoNet protein and cluster: Q71RG4

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: TMUB2_HUMAN, Q71RG4
    Similarity: Contains 1 ubiquitin-like domain


    Find genes that share domains with TMUB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TMUB2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TMUB2:
     Decreased viability of wild-ty  Increased G1 DNA content  Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Tmub2 (no phenotypes)

    Find genes that share phenotypes with TMUB2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tmub2tm1Lex for TMUB2

       genOway: Develop your customized and physiologically relevant rodent model for TMUB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMUB2:
    hsa-mir-18a-5p (MIRT031324), hsa-mir-7-5p (MIRT025707)

    Block miRNA regulation of human, mouse, rat TMUB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMUB2 (see all 37):
    hsa-miR-219-1-3p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-218 hsa-miR-4267 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTMUB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMUB2
    Predesigned siRNA for gene silencing in human, mouse, rat TMUB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMUB2

    Clone
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    OriGene clones in human, mouse for TMUB2 (see all 17)
    OriGene ORF clones in mouse, rat for TMUB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TMUB2 (NM_177441)
    Sino Biological Human cDNA Clone for TMUB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMUB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMUB2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TMUB2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMUB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMUB2_HUMAN, Q71RG4: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMUB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMUB2
    Interactions:

        Search GeneGlobe Interaction Network for TMUB2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TMUB2 (ENSP000003132144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMUB2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMUB2 gene (3 alternative transcripts): 
    NM_001076674.1  NM_024107.2  NM_177441.2  

    Unigene Cluster for TMUB2:

    Transmembrane and ubiquitin-like domain containing 2
    Hs.181391  [show with all ESTs]
    Unigene Representative Sequence: AL833899
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446571 ENST00000538716(uc002ifo.3 uc010wiu.2) ENST00000587989
    ENST00000590235 ENST00000319511(uc002ift.3 uc002ifx.3) ENST00000588413
    ENST00000589785 ENST00000592825 ENST00000589184 ENST00000589856 ENST00000587775
    ENST00000587326 ENST00000587172 ENST00000587630 ENST00000357984(uc002ifp.3 uc002ifr.3 uc002ify.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMUB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMUB2 (see all 37):
    hsa-miR-219-1-3p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-218 hsa-miR-4267 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTMUB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMUB2
    Predesigned siRNA for gene silencing in human, mouse, rat TMUB2
    Clone
    Products:
         
    OriGene clones in human, mouse for TMUB2 (see all 17)
    OriGene ORF clones in mouse, rat for TMUB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TMUB2 (NM_177441)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMUB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMUB2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMUB2
    OriGene qSTAR qPCR primer pairs in human, mouse for TMUB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMUB2
      QuantiTect SYBR Green Assays in human, mouse, rat TMUB2
      QuantiFast Probe-based Assays in human, mouse, rat TMUB2

    Additional mRNA sequence: 

    AF289564.1 AF370373.1 AK294198.1 AL833899.1 AY358780.1 BC001792.1 BC004306.1 BC063489.1 

    Selected DOTS entries (see all 26):

    DT.100786720  DT.40284512  DT.91761517  DT.100786723  DT.446888  DT.80102041  DT.99930302  DT.91761520 
    DT.100789998  DT.120990581  DT.100786721  DT.40109524  DT.91761526  DT.120990537  DT.444946  DT.91761522 
    DT.100786732  DT.95276200  DT.120990610  DT.120990636  DT.40109525  DT.91761519  DT.91761521  DT.91761527 

    Selected AceView cDNA sequences (see all 270):

    CA418877 CR601571 BM714765 BQ003218 CR611525 AU119098 BM987826 BM354200 
    AK021759 Z42306 BC004306 CR594332 CR611823 CR623781 BM678684 AL560355 
    CR591425 AY007092 AL538440 BQ721737 BG489915 AI188886 AL541078 AL526545 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMUB2 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
    SP1:                                -     -     -     -     -     -     -                                                                                       
    SP2:                                -     -     -     -     -     -     -                 -                                                                     
    SP3:                                                                    -                                                                                       
    SP4:                                -     -     -     -     -     -     -           -     -                                                                     
    SP5:                                -     -     -     -     -     -     -     -           -                                                                     


    ECgene alternative splicing isoforms for TMUB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMUB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCAGCAC
    TMUB2 Expression
    About this image


    TMUB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Thyroid (Endocrine System)
    TMUB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMUB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.181391
        Custom PCR Arrays for TMUB2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMUB2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMUB2
    QuantiTect SYBR Green Assays in human, mouse, rat TMUB2
    QuantiFast Probe-based Assays in human, mouse, rat TMUB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMUB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMUB2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmub21 , 5 transmembrane and ubiquitin-like domain containing more1, 5 86.83(n)1
    86.21(a)1
      11 (66.29 cM)5
    720531  NM_028076.21  NP_082352.11 
     1022849315 
    lizard
    (Anolis carolinensis)
    Reptilia TMUB26
    transmembrane and ubiquitin-like domain containing...
    59(a)
    1 ↔ 1
    6(66660004-66675693)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmub21 transmembrane and ubiquitin-like domain containing more 57.67(n)
    55.36(a)
      613061  XM_002935538.2  XP_002935584.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tmub21 transmembrane and ubiquitin-like domain containing more 59.13(n)
    53(a)
      368511  NM_001005573.1  NP_001005573.1 
    worm
    (Caenorhabditis elegans)
    Secernentea B0303.46
    Protein B0303.4 (B0303.4) mRNA, complete cds
    11(a)
    1 → many
    III(8689850-8693473) WBGene00015126


    ENSEMBL Gene Tree for TMUB2 (if available)
    TreeFam Gene Tree for TMUB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMUB2 gene
    TMUB12  
    1 SIMAP similar gene for TMUB2 using alignment to 6 protein entries:     TMUB2_HUMAN (see all proteins):
    TMUB1

    Find genes that share paralogs with TMUB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMUB2 (see all 96)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1856261191,2
    --42266143(+) GGGAAG/TTTGGA 3 -- int10--------
    rs593773931,2
    C,F--42266162(+) GAGGAA/GGGTCA 3 -- int12Minor allele frequency- G:0.11WA 120
    rs1428710711,2
    --42266180(+) TGAAAA/GCAAGA 3 -- int10--------
    rs22402261,2
    C,F,A,H--42266218(-) CTAAAA/GACCTA 3 -- int122Minor allele frequency- G:0.45EA NS NA WA CSA 4022
    rs80735551,2
    C,H--42266224(+) TTTAGC/GTTTAG 3 -- int113Minor allele frequency- G:0.04NA WA CSA EA 378
    rs1505706031,2
    C--42266525(+) ACCTAC/TGTAGC 6 Y syn10--------
    rs1999278281,2
    --42266585(+) ACATCC/TGTCCT 6 S syn10--------
    rs1907766721,2
    C--42266676(+) ATGATG/TAGAAG 6 E * stg10--------
    rs2019050151,2
    --42266800(+) AGCAGA/GTGCAG 6 D G mis10--------
    rs2004119371,2
    C--42266807(+) GCAGGC/GAGCAG 6 G syn11Minor allele frequency- G:0.00EU 1309

    HapMap Linkage Disequilibrium report for TMUB2 (42264338 - 42269099 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TMUB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908269CNV Loss21882294
    nsv833455CNV Loss17160897
    nsv908270CNV Loss21882294
    nsv908271CNV Loss21882294
    dgv529n67CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMUB2
    DNA2.0 Custom Variant and Variant Library Synthesis for TMUB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMUB2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with TMUB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
    6. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79089 HGNC: 28459 AceView: MGC3123 Ensembl:ENSG00000168591 euGenes: HUgn79089
    ECgene: TMUB2 H-InvDB: TMUB2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMUB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMUB2 gene:
    Search GeneIP for patents involving TMUB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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