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Aliases for TMUB2 Gene

Aliases for TMUB2 Gene

  • Transmembrane And Ubiquitin-Like Domain Containing 2 2 3
  • Transmembrane And Ubiquitin-Like Domain-Containing Protein 2 3
  • FP2653 3

External Ids for TMUB2 Gene

Previous GeneCards Identifiers for TMUB2 Gene

  • GC17P039620
  • GC17P042264
  • GC17P038028

Summaries for TMUB2 Gene

GeneCards Summary for TMUB2 Gene

TMUB2 is a Protein Coding gene. An important paralog of this gene is TMUB1.

Gene Wiki entry for TMUB2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMUB2 Gene

Genomics for TMUB2 Gene

Regulatory Elements for TMUB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMUB2 Gene

44,186,956 bp from pter
44,191,731 bp from pter
4,776 bases
Plus strand

Genomic View for TMUB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMUB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMUB2 Gene

Proteins for TMUB2 Gene

  • Protein details for TMUB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and ubiquitin-like domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B3KU81
    • Q8NDI2
    • Q9BPZ5
    • Q9HAG3

    Protein attributes for TMUB2 Gene

    321 amino acids
    Molecular mass:
    33788 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMUB2 Gene


neXtProt entry for TMUB2 Gene

Proteomics data for TMUB2 Gene at MOPED

Post-translational modifications for TMUB2 Gene

  • Ubiquitination at Lys145, Lys179, and Lys212
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMUB2 Gene

Domains for TMUB2 Gene

Protein Domains for TMUB2 Gene

Suggested Antigen Peptide Sequences for TMUB2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q71RG4
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with TMUB2: view

No data available for Gene Families for TMUB2 Gene

Function for TMUB2 Gene

Gene Ontology (GO) - Molecular Function for TMUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMUB2: view
genes like me logo Genes that share phenotypes with TMUB2: view

Animal Model Products

CRISPR Products

miRNA for TMUB2 Gene

miRTarBase miRNAs that target TMUB2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMUB2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMUB2 Gene

Localization for TMUB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMUB2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMUB2 Gene COMPARTMENTS Subcellular localization image for TMUB2 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMUB2: view

Pathways for TMUB2 Gene

SuperPathways for TMUB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMUB2 Gene


No data available for Pathways by source for TMUB2 Gene

Transcripts for TMUB2 Gene

Unigene Clusters for TMUB2 Gene

Transmembrane and ubiquitin-like domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMUB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMUB2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: -
SP9: - -
SP10: -
SP12: - - - - - - - - - -
SP13: - - - - - - - - -
SP14: - - - -
SP15: -
SP16: - -
SP17: - - - - -
SP18: - - -

Relevant External Links for TMUB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMUB2 Gene

mRNA expression in normal human tissues for TMUB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMUB2 Gene

SOURCE GeneReport for Unigene cluster for TMUB2 Gene Hs.181391

genes like me logo Genes that share expressions with TMUB2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMUB2 Gene

Orthologs for TMUB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMUB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMUB2 35
  • 99.58 (n)
  • 100 (a)
TMUB2 36
  • 100 (a)
(Bos Taurus)
Mammalia TMUB2 35
  • 91.81 (n)
  • 93.36 (a)
TMUB2 36
  • 93 (a)
(Canis familiaris)
Mammalia TMUB2 35
  • 93.04 (n)
  • 94.7 (a)
TMUB2 36
  • 92 (a)
(Mus musculus)
Mammalia Tmub2 35
  • 86.83 (n)
  • 86.21 (a)
Tmub2 16
Tmub2 36
  • 84 (a)
(Monodelphis domestica)
Mammalia TMUB2 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia TMUB2 36
  • 68 (a)
(Rattus norvegicus)
Mammalia Tmub2 35
  • 87.46 (n)
  • 86.52 (a)
(Anolis carolinensis)
Reptilia TMUB2 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmub2 35
  • 57.67 (n)
  • 55.36 (a)
(Danio rerio)
Actinopterygii tmub2 35
  • 59.13 (n)
  • 53 (a)
tmub2 36
  • 48 (a)
(Caenorhabditis elegans)
Secernentea B0303.4 36
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5389 36
  • 22 (a)
Species with no ortholog for TMUB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMUB2 Gene

Gene Tree for TMUB2 (if available)
Gene Tree for TMUB2 (if available)

Paralogs for TMUB2 Gene

Paralogs for TMUB2 Gene

Selected SIMAP similar genes for TMUB2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMUB2: view

Variants for TMUB2 Gene

Sequence variations from dbSNP and Humsavar for TMUB2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs757430 -- 44,190,906(-) AGGCC(A/G)TAAAG utr-variant-3-prime
rs2240226 -- 44,188,850(-) CTAAA(A/G)ACCTA intron-variant
rs2285952 -- 44,191,227(-) CAGCC(C/T)TGGGT utr-variant-3-prime
rs2285953 -- 44,190,887(-) CCATG(C/G)CTTTC utr-variant-3-prime
rs8073555 -- 44,188,856(+) TTTAG(C/G/T)TTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMUB2 Gene

Variant ID Type Subtype PubMed ID
nsv833455 CNV Loss 17160897
nsv908269 CNV Loss 21882294
nsv908270 CNV Loss 21882294
nsv908271 CNV Loss 21882294
dgv529n67 CNV Gain 20364138

Relevant External Links for TMUB2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMUB2 Gene

Disorders for TMUB2 Gene

No disorders were found for TMUB2 Gene.

No data available for UniProtKB/Swiss-Prot for TMUB2 Gene

Publications for TMUB2 Gene

  1. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  2. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TMUB2 Gene

Sources for TMUB2 Gene

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