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Aliases for TMUB2 Gene

Aliases for TMUB2 Gene

  • Transmembrane And Ubiquitin Like Domain Containing 2 2 3 5
  • Transmembrane And Ubiquitin-Like Domain-Containing Protein 2 3
  • Transmembrane And Ubiquitin-Like Domain Containing 2 2
  • FP2653 3

External Ids for TMUB2 Gene

Previous GeneCards Identifiers for TMUB2 Gene

  • GC17P039620
  • GC17P042264
  • GC17P038028

Summaries for TMUB2 Gene

GeneCards Summary for TMUB2 Gene

TMUB2 (Transmembrane And Ubiquitin Like Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is TMUB1.

Gene Wiki entry for TMUB2 Gene

Additional gene information for TMUB2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMUB2 Gene

Genomics for TMUB2 Gene

Regulatory Elements for TMUB2 Gene

Enhancers for TMUB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H043322 1.7 Ensembl ENCODE dbSUPER 119 -863.8 -863807 1 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 NFYC ENSG00000267340 UBTF ASB16-AS1 ENSG00000267002 DHX8 HMGN1P29 TMUB2 NBR2 PLEKHH3 LINC00910
GH17H045143 1.8 FANTOM5 ENCODE dbSUPER 94.9 +961.0 960978 9 MLX FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ENSG00000262372 UBTF ASB16-AS1 TMUB2 ENSG00000224505 LINC02210 HEXIM1 EFTUD2 MAP3K14-AS1 ENSG00000260793
GH17H043366 1.7 Ensembl ENCODE dbSUPER 69.4 -818.3 -818255 4 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 DHX8 NBR2 HMGN1P29 ASB16-AS1 LINC00910 TMUB2 UBTF ENSG00000267340 PSME3 NBR1
GH17H044818 1.5 Ensembl ENCODE dbSUPER 35.2 +633.4 633426 3 ARNT ZNF493 ZFP64 FEZF1 ZNF2 ZNF121 KLF7 FOS ZNF202 SP3 UBTF ASB16-AS1 TMUB2 GPATCH8 GJC1 MPP2 ENSG00000260793 EFTUD2 HIGD1B ENSG00000224505
GH17H044707 1.1 ENCODE 39.6 +521.7 521699 2 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF143 DBF4B TMUB2 ASB16-AS1 ENSG00000224505 UBTF EFTUD2 C17orf53 HEXIM1 MAP3K14-AS1 ENSG00000260793
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMUB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMUB2 Gene

Chromosome:
17
Start:
44,186,969 bp from pter
End:
44,191,731 bp from pter
Size:
4,763 bases
Orientation:
Plus strand

Genomic View for TMUB2 Gene

Genes around TMUB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMUB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMUB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMUB2 Gene

Proteins for TMUB2 Gene

  • Protein details for TMUB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q71RG4-TMUB2_HUMAN
    Recommended name:
    Transmembrane and ubiquitin-like domain-containing protein 2
    Protein Accession:
    Q71RG4
    Secondary Accessions:
    • B3KU81
    • Q8NDI2
    • Q9BPZ5
    • Q9HAG3

    Protein attributes for TMUB2 Gene

    Size:
    321 amino acids
    Molecular mass:
    33788 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMUB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMUB2 Gene

Post-translational modifications for TMUB2 Gene

  • Ubiquitination at Lys145, posLast=179179, and posLast=212212
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMUB2 Gene

Domains & Families for TMUB2 Gene

Gene Families for TMUB2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMUB2 Gene

Suggested Antigen Peptide Sequences for TMUB2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMUB2: view

No data available for UniProtKB/Swiss-Prot for TMUB2 Gene

Function for TMUB2 Gene

Phenotypes From GWAS Catalog for TMUB2 Gene

Gene Ontology (GO) - Molecular Function for TMUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMUB2: view
genes like me logo Genes that share phenotypes with TMUB2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMUB2

CRISPR Products

miRNA for TMUB2 Gene

miRTarBase miRNAs that target TMUB2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMUB2 Gene

Localization for TMUB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMUB2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMUB2 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMUB2: view

Pathways & Interactions for TMUB2 Gene

SuperPathways for TMUB2 Gene

No Data Available

Interacting Proteins for TMUB2 Gene

Gene Ontology (GO) - Biological Process for TMUB2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMUB2 Gene

Drugs & Compounds for TMUB2 Gene

No Compound Related Data Available

Transcripts for TMUB2 Gene

Unigene Clusters for TMUB2 Gene

Transmembrane and ubiquitin-like domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMUB2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: -
SP8:
SP9: - -
SP10: -
SP11:
SP12: - - - - - - - - - -
SP13: - - - - - - - - -
SP14: - - - -
SP15: -
SP16: - -
SP17: - - - - -
SP18: - - -

Relevant External Links for TMUB2 Gene

GeneLoc Exon Structure for
TMUB2
ECgene alternative splicing isoforms for
TMUB2

Expression for TMUB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMUB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMUB2 Gene

This gene is overexpressed in Breast (41.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMUB2 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMUB2 Gene:

TMUB2

SOURCE GeneReport for Unigene cluster for TMUB2 Gene:

Hs.181391

Evidence on tissue expression from TISSUES for TMUB2 Gene

  • Nervous system(4.6)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with TMUB2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMUB2 Gene

Orthologs for TMUB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMUB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMUB2 33 34
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia TMUB2 33 34
  • 93.04 (n)
cow
(Bos Taurus)
Mammalia TMUB2 33 34
  • 91.81 (n)
rat
(Rattus norvegicus)
Mammalia Tmub2 33
  • 87.46 (n)
mouse
(Mus musculus)
Mammalia Tmub2 33 16 34
  • 86.83 (n)
oppossum
(Monodelphis domestica)
Mammalia TMUB2 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMUB2 34
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMUB2 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmub2 33
  • 57.67 (n)
zebrafish
(Danio rerio)
Actinopterygii tmub2 33 34
  • 59.13 (n)
worm
(Caenorhabditis elegans)
Secernentea B0303.4 34
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5389 34
  • 22 (a)
OneToMany
Species where no ortholog for TMUB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMUB2 Gene

ENSEMBL:
Gene Tree for TMUB2 (if available)
TreeFam:
Gene Tree for TMUB2 (if available)

Paralogs for TMUB2 Gene

Paralogs for TMUB2 Gene

(1) SIMAP similar genes for TMUB2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMUB2: view

Variants for TMUB2 Gene

Sequence variations from dbSNP and Humsavar for TMUB2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000341675 -- 44,187,027(+) GATTG(C/T)CAGCC upstream-variant-2KB, utr-variant-5-prime
rs1000545036 -- 44,186,787(+) CCTAA(G/T)GCCCC upstream-variant-2KB
rs1000945378 -- 44,186,035(+) TTAAT(C/T)GCGGC intron-variant, upstream-variant-2KB
rs1001002248 -- 44,187,043(+) CCCGA(C/T)CCCTA upstream-variant-2KB, utr-variant-5-prime
rs1001481539 -- 44,192,351(+) AACCA(C/G)TTCCC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMUB2 Gene

Variant ID Type Subtype PubMed ID
dgv529n67 CNV gain 20364138
nsv1146669 OTHER inversion 26484159
nsv833455 CNV loss 17160897

Variation tolerance for TMUB2 Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.11; 61.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMUB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMUB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMUB2 Gene

Disorders for TMUB2 Gene

Relevant External Links for TMUB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMUB2

No disorders were found for TMUB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMUB2 Gene

Publications for TMUB2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  5. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 60

Products for TMUB2 Gene

Sources for TMUB2 Gene

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