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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMUB1 Gene

protein-coding   GIFtS: 47
GCID: GC07M150778

transmembrane and ubiquitin-like domain containing 1

(Previous name: chromosome 7 open reading frame 21 )
(Previous symbol: C7orf21)
  Search for TMUB1
in our new
 Human Malady Compendium 
Biological research products
for TMUB1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Transmembrane And Ubiquitin-Like Domain Containing 11 2     SB1441
C7orf211 2 3     Chromosome 7 Open Reading Frame 211
Dendritic Cell-Derived Ubiquitin-Like Protein2 3     Transmembrane And Ubiquitin-Like Domain-Containing Protein 12
Hepatocyte Odd Protein Shuttling Protein2 3     Ubiquitin-Like Protein DULP2
Ubiquitin-Like Protein SB1442 3     HOPS3
DULP2 3     

External Ids:    HGNC: 217091   Entrez Gene: 835902   Ensembl: ENSG000001648977   OMIM: 6147925   UniProtKB: Q9BVT83   

Export aliases for TMUB1 gene to outside databases

Previous GC identifers: GC07M150409 GC07M144590


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TMUB1_HUMAN, Q9BVT8
Function: May contribute to the regulation of translation during cell-cycle progression. May contribute to the
regulation of cell proliferation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMUB1 gene promoter:
         GR   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMUB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMUB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMUB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

TMUB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMUB1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M150778:  view genomic region     (about GC identifiers)

Start:
150,778,167 bp from pter      End:
150,780,633 bp from pter
Size:
2,467 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 150,107,712-150,110,158     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TMUB1_HUMAN, Q9BVT8 (See protein sequence)
Recommended Name: Transmembrane and ubiquitin-like domain-containing protein 1  
Size: 246 amino acids; 26261 Da
Subunit: Interacts with EEF1A1 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Nucleus. Note=Predominantly nuclear
during growth arrest (By similarity). Actively exported from the nucleus in dividing cells
Secondary accessions: D3DX06 Q53AQ2

Explore the universe of human proteins at neXtProt for TMUB1: NX_Q9BVT8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BVT8

  • TMUB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129516.1  NP_113622.1  

    ENSEMBL proteins: 
     ENSP00000297533   ENSP00000376565   ENSP00000417519   ENSP00000418709   ENSP00000419214  
     ENSP00000420692   ENSP00000420516  

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    Novus Biologicals TMUB1 Protein
    Novus Biologicals TMUB1 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TMUB1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016021integral to membrane IEA--


    TMUB1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TMUB1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TMUB1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000626 Ubiquitin
     IPR019955 Ubiquitin_supergroup

    Graphical View of Domain Structure for InterPro Entry Q9BVT8

    ProtoNet protein and cluster: Q9BVT8

    1 Blocks protein family: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: TMUB1_HUMAN, Q9BVT8
    Similarity: Contains 1 ubiquitin-like domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TMUB1_HUMAN, Q9BVT8
    Function: May contribute to the regulation of translation during cell-cycle progression. May contribute to the
    regulation of cell proliferation (By similarity)

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate TMUB1:
    hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-1285 hsa-miR-646 hsa-miR-612 hsa-miR-661 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidTMUB1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMUB1 (see all 7)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMUB1

    2 GenomeRNAi human phenotypes for TMUB1:
     Decreased number of cells in m  Increased Salmonella enterica  

    Animal Models:
         Mouse knock-out Tmub1tm1Lex for TMUB1
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tmub1):
     adipose tissue  behavior/neurological  hematopoietic system  immune system 

    TMUB1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMUB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for TMUB1 (Q9BVT83 ENSP000002975334) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMFRQ9UKV53, ENSP000002906494I2D: score=1 STRING: ENSP00000290649
    ERLIN2O949053, ENSP000002764614I2D: score=1 STRING: ENSP00000276461
    RNF139Q8WU173, ENSP000003040514I2D: score=1 STRING: ENSP00000304051
    SYVN1Q86TM63, ENSP000003663954I2D: score=1 STRING: ENSP00000366395
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMUB1
    Search CenterWatch for drugs/clinical trials and news about TMUB1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMUB1 gene (2 alternative transcripts): 
    NM_001136044.1  NM_031434.3  

    Unigene Cluster for TMUB1:

    Transmembrane and ubiquitin-like domain containing 1
    Hs.726215  [show with all ESTs]
    Unigene Representative Sequence: NM_031434
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297533(uc003wjd.3) ENST00000392818(uc003wjc.3) ENST00000462940(uc003wjb.3)
    ENST00000482202 ENST00000476627 ENST00000488752 ENST00000492838

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate TMUB1:
    hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-1285 hsa-miR-646 hsa-miR-612 hsa-miR-661 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidTMUB1 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: TMUB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMUB1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): TMUB1 (NM_001136044)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMUB1
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    Additional cDNA sequence: 

    AK314035.1 AY037155.1 AY358481.1 AY603380.1 BC000936.1 BC033182.1 

    13 DOTS entries:

    DT.111352  DT.92437033  DT.92437031  DT.95188413  DT.100818438  DT.100818435  DT.100818443  DT.99926386 
    DT.95188388  DT.97847803  DT.100818436  DT.100818440  DT.100844948 

    24/631 AceView cDNA sequences (see all 631):

    BU634380 CA489469 CR624473 CR593124 CR596093 CF134787 BM552664 BM693823 
    BG751796 BM850581 BM843404 BC006386 BU194241 BM705064 BE311994 BM470020 
    BQ438215 BC000377 BQ673845 BQ948849 CB852168 BQ067976 CR595036 BM709099 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TMUB1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:        -     -     -     -     -     -     -     -                                 
    SP2:              -     -     -     -     -     -     -                                 
    SP3:                    -     -     -     -     -     -                                 
    SP4:                          -     -     -     -     -                                 
    SP5:                                                  -     -                           


    ECgene alternative splicing isoforms for TMUB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMUB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACCGCCCGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TMUB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMUB1

    SOURCE GeneReport for Unigene cluster: Hs.726215
        SABiosciences Custom PCR Arrays for TMUB1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMUB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMUB1 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TMUB11 transmembrane and ubiquitin-like domain containing more 70.86(n)
    60.84(a)
      431107  XM_428658.3  XP_428658.3 
    lizard
    (Anolis carolinensis)
    Reptilia TMUB16
    --
    43(a)
    1 ↔ 1
    AAWZ02040777(574-6216)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.117602 Transcribed sequence with weak similarity to protein more 71.72(n)    BX699569.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa98b102 Transcribed sequence with weak similarity to protein more 71.57(n)    CK027052.1 
    worm
    (Caenorhabditis elegans)
    Secernentea B0303.46
    Uncharacterized protein B0303.4
    10(a)
    1 → many
    III(8689769-8693392)


    ENSEMBL Gene Tree for TMUB1 (if available)
    TreeFam Gene Tree for TMUB1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMUB1 gene
    TMUB22  
    1 SIMAP similar gene for TMUB1 using alignment to 3 protein entries:     TMUB1_HUMAN (see all proteins):
    TMUB2

    TMUB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/30 NCBI SNPs in TMUB1 are shown (see all 30    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1897954291,2
    --150779989(+) TTCACC/TCCAAC 2 -- int1 ut510--------
    rs1824397801,2
    --150780169(+) CCCCAC/TCCGCG 2 -- int1 ut510--------
    rs1879630731,2
    --150780245(+) GCCACC/TGAGCG 2 -- int1 ut510--------
    rs1910093191,2
    --150780436(+) GCCCCC/TCGAAG 2 -- us2k1 int10--------
    rs1439825501,2
    --150780530(+) CGGCTC/TCCCCA 2 -- us2k1 ut510--------
    rs1464702341,2
    --150780600(+) AAGCAA/CCCCTC 2 -- us2k1 ut510--------
    rs1509857261,2
    --150780742(+) GGGGC-/GGGTTT 2 -- us2k10--------
    rs1834238861,2
    --150780768(+) GCTACC/TCCCTA 2 -- us2k10--------
    rs69621001,2
    C,H,--150780933(+) TGTCAG/CAGTGG 2 -- us2k115Minor allele frequency- C:0.00NS EA NA WA CSA 669
    rs1873478581,2
    --150780978(+) CTTCAA/GCCCAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMUB1 (150778167 - 150780633 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TMUB1
         1 CNV: 4574

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TMUB1 for disorders           About MalaCards

    TMUB1 for disorders           About GeneDecksing

    OMIM gene information: 614792    OMIM disorders: --


    Export disorders for TMUB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMUB1 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with TMUB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of DULP, a novel ubiquitin-like molecule from human dendritic cells. (PubMed id 19254477)1, 2 Liu G.Y.... Yu Y.Z. (2009)
    2. HOPS: a novel cAMP-dependent shuttling protein involved in protein synthesis regulation. (PubMed id 16014383)1, 2 Della Fazia M.A.... Servillo G. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    8. Membrane-associated ubiquitin ligase complex containi ng gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-c oenzyme A reductase. (PubMed id 21343306)1 Jo Y....DeBose-Boyd R.A. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83590 HGNC: 21709 AceView: FASTKandC7orf21 Ensembl:ENSG00000164897 euGenes: HUgn83590
    ECgene: TMUB1 H-InvDB: TMUB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMUB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMUB1 gene:
    Search GeneIP for patents involving TMUB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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