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Aliases for TMUB1 Gene

Aliases for TMUB1 Gene

  • C7orf21 3 4 6
  • DULP 3 4 6
  • Transmembrane And Ubiquitin-Like Domain Containing 1 2 3
  • Dendritic Cell-Derived Ubiquitin-Like Protein 3 4
  • Hepatocyte Odd Protein Shuttling Protein 3 4
  • Ubiquitin-Like Protein SB144 3 4
  • SB144 3 6
  • Transmembrane And Ubiquitin-Like Domain-Containing Protein 1 3
  • Chromosome 7 Open Reading Frame 21 2
  • Ubiquitin-Like Protein DULP 3
  • HOPS 4

External Ids for TMUB1 Gene

Previous HGNC Symbols for TMUB1 Gene

  • C7orf21

Previous GeneCards Identifiers for TMUB1 Gene

  • GC07M150409
  • GC07M150778
  • GC07M144590

Summaries for TMUB1 Gene

GeneCards Summary for TMUB1 Gene

TMUB1 is a Protein Coding gene. An important paralog of this gene is TMUB2.

UniProtKB/Swiss-Prot for TMUB1 Gene

  • May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMUB1 Gene

Genomics for TMUB1 Gene

Regulatory Elements for TMUB1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMUB1 Gene

151,081,080 bp from pter
151,083,546 bp from pter
2,467 bases
Minus strand

Genomic View for TMUB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMUB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMUB1 Gene

Proteins for TMUB1 Gene

  • Protein details for TMUB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and ubiquitin-like domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • D3DX06
    • Q53AQ2

    Protein attributes for TMUB1 Gene

    246 amino acids
    Molecular mass:
    26261 Da
    Quaternary structure:
    • Interacts with EEF1A1.

neXtProt entry for TMUB1 Gene

Proteomics data for TMUB1 Gene at MOPED

Post-translational modifications for TMUB1 Gene

  • Ubiquitination at Lys108 and Lys129
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TMUB1

No data available for DME Specific Peptides for TMUB1 Gene

Domains for TMUB1 Gene

Protein Domains for TMUB1 Gene

Suggested Antigen Peptide Sequences for TMUB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ubiquitin-like domain.
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with TMUB1: view

No data available for Gene Families for TMUB1 Gene

Function for TMUB1 Gene

Molecular function for TMUB1 Gene

UniProtKB/Swiss-Prot Function:
May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity).

Gene Ontology (GO) - Molecular Function for TMUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TMUB1: view
genes like me logo Genes that share phenotypes with TMUB1: view

Animal Models for TMUB1 Gene

MGI Knock Outs for TMUB1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMUB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TMUB1 Gene

Localization for TMUB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMUB1 Gene

Membrane; Multi-pass membrane protein. Cytoplasm. Nucleus. Note=Predominantly nuclear during growth arrest (By similarity). Actively exported from the nucleus in dividing cells. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TMUB1 Gene COMPARTMENTS Subcellular localization image for TMUB1 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 3
extracellular 2

Gene Ontology (GO) - Cellular Components for TMUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMUB1: view

Pathways for TMUB1 Gene

SuperPathways for TMUB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMUB1 Gene


No data available for Pathways by source for TMUB1 Gene

Transcripts for TMUB1 Gene

Unigene Clusters for TMUB1 Gene

Transmembrane and ubiquitin-like domain containing 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMUB1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMUB1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7: - -

Relevant External Links for TMUB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMUB1 Gene

mRNA expression in normal human tissues for TMUB1 Gene

Protein differential expression in normal tissues for TMUB1 Gene

This gene is overexpressed in Liver (8.4), Bone (8.0), Testis (6.6), and Fetal testis (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMUB1 Gene

SOURCE GeneReport for Unigene cluster for TMUB1 Gene Hs.726215

genes like me logo Genes that share expressions with TMUB1: view

Expression partners for TMUB1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMUB1 Gene

Orthologs for TMUB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMUB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMUB1 35
  • 90.38 (n)
  • 93.09 (a)
TMUB1 36
  • 93 (a)
(Canis familiaris)
Mammalia TMUB1 35
  • 91.46 (n)
  • 93.9 (a)
TMUB1 36
  • 93 (a)
(Mus musculus)
Mammalia Tmub1 35
  • 87.48 (n)
  • 89.8 (a)
Tmub1 16
Tmub1 36
  • 89 (a)
(Pan troglodytes)
Mammalia TMUB1 35
  • 100 (n)
  • 100 (a)
TMUB1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmub1 35
  • 87.35 (n)
  • 90.61 (a)
(Monodelphis domestica)
Mammalia TMUB1 36
  • 71 (a)
(Gallus gallus)
Aves TMUB1 35
  • 69.93 (n)
  • 58.74 (a)
TMUB1 36
  • 47 (a)
(Anolis carolinensis)
Reptilia TMUB1 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11760 35
(Danio rerio)
Actinopterygii tmub1 35
  • 57.41 (n)
  • 52.24 (a)
wufa98b10 35
tmub1 36
  • 40 (a)
(Caenorhabditis elegans)
Secernentea B0303.4 36
  • 8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5389 36
  • 22 (a)
Species with no ortholog for TMUB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMUB1 Gene

Gene Tree for TMUB1 (if available)
Gene Tree for TMUB1 (if available)

Paralogs for TMUB1 Gene

Paralogs for TMUB1 Gene

(1) SIMAP similar genes for TMUB1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMUB1: view

Variants for TMUB1 Gene

Sequence variations from dbSNP and Humsavar for TMUB1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs143982550 -- 151,083,443(+) CGGCT(C/T)CCCCA utr-variant-5-prime, upstream-variant-2KB
rs146470234 -- 151,083,513(+) AAGCA(A/C)CCCTC utr-variant-5-prime, upstream-variant-2KB
rs150985726 -- 151,083,660(+) GGGGC(-/G)GGTTT upstream-variant-2KB
rs182439780 -- 151,083,082(+) CCCCA(C/T)CCGCG intron-variant, utr-variant-5-prime
rs183423886 -- 151,083,681(+) GCTAC(C/T)CCCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMUB1 Gene

Variant ID Type Subtype PubMed ID
nsv889465 CNV Loss 21882294
nsv889476 CNV Loss 21882294
nsv889477 CNV Loss 21882294
dgv7545n71 CNV Loss 21882294
nsv831188 CNV Loss 17160897
dgv7546n71 CNV Loss 21882294
nsv465215 CNV Loss 19166990
nsv6004 CNV Insertion 18451855
dgv7547n71 CNV Loss 21882294
dgv7548n71 CNV Loss 21882294

Relevant External Links for TMUB1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMUB1 Gene

Disorders for TMUB1 Gene

No disorders were found for TMUB1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMUB1 Gene

Publications for TMUB1 Gene

  1. Cloning and characterization of DULP, a novel ubiquitin-like molecule from human dendritic cells. (PMID: 19254477) Liu G.Y. … Yu Y.Z. (Cell. Mol. Immunol. 2009) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. HOPS: a novel cAMP-dependent shuttling protein involved in protein synthesis regulation. (PMID: 16014383) Della Fazia M.A. … Servillo G. (J. Cell Sci. 2005) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TMUB1 Gene

  • Addgene plasmids for TMUB1

Sources for TMUB1 Gene

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