Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TMUB1 Gene

protein-coding   GIFtS: 46
GCID: GC07M150778

Transmembrane And Ubiquitin-Like Domain Containing 1

(Previous name: chromosome 7 open reading frame 21)
(Previous symbol: C7orf21)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Transmembrane And Ubiquitin-Like Domain Containing 11 2     Chromosome 7 Open Reading Frame 211
C7orf211 2 3 5     Transmembrane And Ubiquitin-Like Domain-Containing Protein 12
DULP2 3 5     Ubiquitin-Like Protein DULP2
Dendritic Cell-Derived Ubiquitin-Like Protein2 3     HOPS3
Hepatocyte Odd Protein Shuttling Protein2 3     SB1445
Ubiquitin-Like Protein SB1442 3     

External Ids:    HGNC: 217091   Entrez Gene: 835902   Ensembl: ENSG000001648977   OMIM: 6147925   UniProtKB: Q9BVT83   

Export aliases for TMUB1 gene to outside databases

Previous GC identifers: GC07M150409 GC07M144590


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TMUB1 Gene:
TMUB1 (transmembrane and ubiquitin-like domain containing 1) is a protein-coding gene. An important paralog of this gene is TMUB2.

UniProtKB/Swiss-Prot: TMUB1_HUMAN, Q9BVT8
Function: May contribute to the regulation of translation during cell-cycle progression. May contribute to the
regulation of cell proliferation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the TMUB1 gene promoter:
         GR   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMUB1 promoter sequence
   Search Chromatin IP Primers for TMUB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMUB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

TMUB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMUB1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M150778:  view genomic region     (about GC identifiers)

Start:
150,778,167 bp from pter      End:
150,780,633 bp from pter
Size:
2,467 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 150,107,712-150,110,158     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TMUB1_HUMAN, Q9BVT8 (See protein sequence)
Recommended Name: Transmembrane and ubiquitin-like domain-containing protein 1  
Size: 246 amino acids; 26261 Da
Subunit: Interacts with EEF1A1 (By similarity)
Secondary accessions: D3DX06 Q53AQ2

Explore the universe of human proteins at neXtProt for TMUB1: NX_Q9BVT8

Explore proteomics data for TMUB1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys108, Lys129
  • Modification sites at PhosphoSitePlus

  • See TMUB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129516.1  NP_113622.1  

    ENSEMBL proteins: 
     ENSP00000297533   ENSP00000376565   ENSP00000417519   ENSP00000418709   ENSP00000419214  
     ENSP00000420692   ENSP00000420516  

    TMUB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for TMUB1
    OriGene Protein Over-expression Lysate for TMUB1
    OriGene MassSpec for TMUB1
    OriGene Custom Protein Services for TMUB1
    GenScript Custom Purified and Recombinant Proteins Services for TMUB1
    Novus Biologicals TMUB1 Protein
    Novus Biologicals TMUB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMUB1

     
    Search eBioscience for Proteins for TMUB1 

    TMUB1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TMUB1
    Novus Biologicals TMUB1 Antibodies
    Abcam antibodies for TMUB1
    Cloud-Clone Corp. Antibodies for TMUB1
    ThermoFisher Antibodies for TMUB1
    LSBio Antibodies in human, mouse, rat for TMUB1

    TMUB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TMUB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMUB1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMUB1
    Cloud-Clone Corp. CLIAs for TMUB1
    Search eBioscience for ELISAs for TMUB1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR000626 Ubiquitin_dom

    Graphical View of Domain Structure for InterPro Entry Q9BVT8

    ProtoNet protein and cluster: Q9BVT8

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: TMUB1_HUMAN, Q9BVT8
    Similarity: Contains 1 ubiquitin-like domain


    Find genes that share domains with TMUB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMUB1_HUMAN, Q9BVT8
    Function: May contribute to the regulation of translation during cell-cycle progression. May contribute to the
    regulation of cell proliferation (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TMUB1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TMUB1:
     Decreased number of cells in m  Increased Salmonella enterica  

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tmub1):
     adipose tissue  behavior/neurological  growth/size/body  hematopoietic system  immune system 

    Find genes that share phenotypes with TMUB1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tmub1tm1Lex for TMUB1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMUB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMUB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMUB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMUB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMUB1:
    hsa-mir-25-3p (MIRT050340), hsa-mir-92a-3p (MIRT049837), hsa-mir-615-3p (MIRT039677), hsa-mir-222-3p (MIRT046628), hsa-mir-1250-5p (MIRT035865), hsa-mir-423-5p (MIRT038072)

    Block miRNA regulation of human, mouse, rat TMUB1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate TMUB1:
    hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-1285 hsa-miR-646 hsa-miR-612 hsa-miR-661 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidTMUB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMUB1
    Predesigned siRNA for gene silencing in human, mouse, rat TMUB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMUB1

    Clone
    Products:
         
    OriGene clones in human, mouse for TMUB1 (see all 11)
    OriGene ORF clones in mouse, rat for TMUB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMUB1 (NM_001136044)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMUB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMUB1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TMUB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TMUB1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMUB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TMUB1_HUMAN, Q9BVT8: Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Nucleus. Note=Predominantly
    nuclear during growth arrest (By similarity). Actively exported from the nucleus in dividing cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    plasma membrane3
    extracellular2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMUB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMUB1
    Interactions:

        Search GeneGlobe Interaction Network for TMUB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for TMUB1 (Q9BVT83 ENSP000002975334) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMFRQ9UKV53, ENSP000002906494I2D: score=1 STRING: ENSP00000290649
    ERLIN2O949053, ENSP000002764614I2D: score=1 STRING: ENSP00000276461
    RNF139Q8WU173, ENSP000003040514I2D: score=1 STRING: ENSP00000304051
    SYVN1Q86TM63, ENSP000003663954I2D: score=1 STRING: ENSP00000366395
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMUB1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TMUB1 gene (2 alternative transcripts): 
    NM_001136044.1  NM_031434.3  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297533(uc003wjd.3) ENST00000392818(uc003wjc.3) ENST00000462940(uc003wjb.3)
    ENST00000482202 ENST00000476627 ENST00000488752 ENST00000492838
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMUB1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate TMUB1:
    hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-1285 hsa-miR-646 hsa-miR-612 hsa-miR-661 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidTMUB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMUB1
    Predesigned siRNA for gene silencing in human, mouse, rat TMUB1
    Clone
    Products:
         
    OriGene clones in human, mouse for TMUB1 (see all 11)
    OriGene ORF clones in mouse, rat for TMUB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMUB1 (NM_001136044)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMUB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMUB1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMUB1
    OriGene qSTAR qPCR primer pairs in human, mouse for TMUB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMUB1
      QuantiTect SYBR Green Assays in human, mouse, rat TMUB1
      QuantiFast Probe-based Assays in human, mouse, rat TMUB1

    Selected AceView cDNA sequences (see all 631):

    BX375350 BM559407 BG751796 BM799420 CR596093 BM552664 BQ217247 BU190561 
    BM843404 AA877731 BU194241 BM705064 BM763728 BM926927 BX422323 BQ438215 
    BM693823 BM709099 CA489469 CF134787 BQ067976 BM850581 BG753967 CD673714 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMUB1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:        -     -     -     -     -     -     -     -                                 
    SP2:              -     -     -     -     -     -     -                                 
    SP3:                    -     -     -     -     -     -                                 
    SP4:                          -     -     -     -     -                                 
    SP5:                                                  -     -                           


    ECgene alternative splicing isoforms for TMUB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TMUB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCGCCCGT
    TMUB1 Expression
    About this image

    TMUB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMUB1 Protein Expression
        Custom PCR Arrays for TMUB1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMUB1
    OriGene qSTAR qPCR primer pairs in human, mouse for TMUB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMUB1
    QuantiTect SYBR Green Assays in human, mouse, rat TMUB1
    QuantiFast Probe-based Assays in human, mouse, rat TMUB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMUB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TMUB1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmub11 , 5 transmembrane and ubiquitin-like domain containing more1, 5 87.48(n)1
    89.8(a)1
      5 (11.79 cM)5
    642951  NM_022418.31  NP_071863.11 
     244454585 
    chicken
    (Gallus gallus)
    Aves TMUB11 transmembrane and ubiquitin-like domain containing more 69.93(n)
    58.74(a)
      431107  XM_428658.3  XP_428658.3 
    lizard
    (Anolis carolinensis)
    Reptilia TMUB16
    transmembrane and ubiquitin-like domain containing...
    47(a)
    1 ↔ 1
    AAWZ02040777(21-6444)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.117602 Transcribed sequence with weak similarity to protein more 71.72(n)    BX699569.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa98b102 Transcribed sequence with weak similarity to protein more 71.57(n)    CK027052.1 
    worm
    (Caenorhabditis elegans)
    Secernentea B0303.46
    Protein B0303.4 (B0303.4) mRNA, complete cds
    8(a)
    1 → many
    III(8689850-8693473) WBGene00015126


    ENSEMBL Gene Tree for TMUB1 (if available)
    TreeFam Gene Tree for TMUB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TMUB1 gene
    TMUB22  
    1 SIMAP similar gene for TMUB1 using alignment to 3 protein entries:     TMUB1_HUMAN (see all proteins):
    TMUB2

    Find genes that share paralogs with TMUB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TMUB1 (see all 29)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1897954291,2
    --150779989(+) TTCACC/TCCAAC 2 -- int1 ut510--------
    rs1824397801,2
    --150780169(+) CCCCAC/TCCGCG 2 -- int1 ut510--------
    rs1879630731,2
    --150780245(+) GCCACC/TGAGCG 2 -- int1 ut510--------
    rs1910093191,2
    --150780436(+) GCCCCC/TCGAAG 2 -- int1 us2k10--------
    rs1439825501,2
    C--150780530(+) CGGCTC/TCCCCA 2 -- ut51 us2k10--------
    rs1464702341,2
    --150780600(+) AAGCAA/CCCCTC 2 -- ut51 us2k10--------
    rs1509857261,2
    C--150780747(+) GGGGC-/GGGTTT 2 -- us2k10--------
    rs1834238861,2
    --150780768(+) GCTACC/TCCCTA 2 -- us2k10--------
    rs69621001,2
    C,H--150780933(+) TGTCAG/CAGTGG 2 -- us2k115Minor allele frequency- C:0.00NS EA NA WA CSA 669
    rs1873478581,2
    --150780978(+) CTTCAA/GCCCAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMUB1 (150778167 - 150780633 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for TMUB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6004CNV Insertion18451855
    dgv7547n71CNV Loss21882294
    dgv7546n71CNV Loss21882294
    dgv7548n71CNV Loss21882294
    nsv889477CNV Loss21882294
    nsv465215CNV Loss19166990
    nsv889465CNV Loss21882294
    dgv7545n71CNV Loss21882294
    nsv831188CNV Loss17160897
    nsv889476CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TMUB1
    DNA2.0 Custom Variant and Variant Library Synthesis for TMUB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614792    OMIM disorders: --


    Find genes that share disorders with TMUB1           About GenesLikeMe


    Export disorders for TMUB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TMUB1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with TMUB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of DULP, a novel ubiquitin-like molecule from human dendritic cells. (PubMed id 19254477)1, 2 Liu G.Y.... Yu Y.Z. (Cell. Mol. Immunol. 2009)
    2. HOPS: a novel cAMP-dependent shuttling protein involved in protein synthesis regulation. (PubMed id 16014383)1, 2 Della Fazia M.A.... Servillo G. (J. Cell Sci. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (Mol. Endocrinol. 2013)
    6. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. (PubMed id 21343306)1 Jo Y....DeBose-Boyd R.A. (J. Biol. Chem. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 83590 HGNC: 21709 AceView: FASTKandC7orf21 Ensembl:ENSG00000164897 euGenes: HUgn83590
    ECgene: TMUB1 H-InvDB: TMUB1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TMUB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TMUB1 gene:
    Search GeneIP for patents involving TMUB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TMUB1  
     OriGene qPCR primer pairs and template standards for TMUB1   OriGene Protein Over-expression Lysate for TMUB1  
     OriGene MassSpec something-or-other for TMUB1   OriGene clones in human, mouse for TMUB1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TMUB1   OriGene Purified Protein for TMUB1  
     OriGene ORF clones in mouse, rat for TMUB1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TMUB1   OriGene Custom Protein Services for TMUB1  

     
     
     Block miRNA regulation of human, mouse, rat TMUB1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TMUB1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMUB1 Predesigned siRNA for gene silencing in human, mouse, rat TMUB1
     QuantiFast Probe-based Assays in human, mouse, rat TMUB1 QuantiTect SYBR Green Assays in human, mouse, rat TMUB1
     Custom PCR Arrays for TMUB1 Search Chromatin IP Primers for TMUB1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMUB1  Search GeneGlobe Interaction Network for TMUB1
     Regulatory tfbs in TMUB1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TMUB1 GenScript cDNA clones with any tag delivered in your preferred vector for TMUB1
     GenScript Custom Assay Services for TMUB1 GenScript Custom overexpressing Cell Line Services for TMUB1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TMUB1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TMUB1 antibodies
     TMUB1 proteins
     TMUB1 lysates
     Antibodies for TMUB1
     See all of Abcam's Antibodies, Kits and Proteins for TMUB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TMUB1
     Antibodies for TMUB1
     ELISAs for TMUB1
     CLIAs for TMUB1



     Browse ESI BIO Cell Lines and PureStem Progenitors for TMUB1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMUB1
     SwitchGear 3'UTR luciferase reporter plasmids for TMUB1
     SwitchGear Promoter luciferase reporter plasmids for TMUB1
     ThermoFisher Antibodies for TMUB1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMUB1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMUB1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMUB1
     LSBio Antibodies in human, mouse, rat for TMUB1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for TMUB1
      Search eBioscience for proteins for TMUB1
      Search eBioscience for elisas for TMUB1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TMUB1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4