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Aliases for TMTC4 Gene

Aliases for TMTC4 Gene

  • Transmembrane And Tetratricopeptide Repeat Containing 4 2 3

External Ids for TMTC4 Gene

Previous GeneCards Identifiers for TMTC4 Gene

  • GC13M100055
  • GC13M101256
  • GC13M081852

Summaries for TMTC4 Gene

GeneCards Summary for TMTC4 Gene

TMTC4 is a Protein Coding gene. An important paralog of this gene is TMTC3.

Gene Wiki entry for TMTC4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMTC4 Gene

Genomics for TMTC4 Gene

Regulatory Elements for TMTC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMTC4 Gene

Start:
100,603,836 bp from pter
End:
100,675,093 bp from pter
Size:
71,258 bases
Orientation:
Minus strand

Genomic View for TMTC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMTC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMTC4 Gene

Proteins for TMTC4 Gene

  • Protein details for TMTC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4D3-TMTC4_HUMAN
    Recommended name:
    Transmembrane and TPR repeat-containing protein 4
    Protein Accession:
    Q5T4D3
    Secondary Accessions:
    • A6NLI7
    • B7Z666
    • Q5T4D4
    • Q5T4D5
    • Q5T4D6
    • Q8WV63
    • Q96SU8

    Protein attributes for TMTC4 Gene

    Size:
    741 amino acids
    Molecular mass:
    82991 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH18707.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AK056409; Type=Frameshift; Positions=268; Evidence={ECO:0000305}; Sequence=BAB55179.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI11004.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI11005.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI11006.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMTC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMTC4 Gene

Proteomics data for TMTC4 Gene at MOPED

Post-translational modifications for TMTC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMTC4 Gene

Domains for TMTC4 Gene

Gene Families for TMTC4 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for TMTC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T4D3

UniProtKB/Swiss-Prot:

TMTC4_HUMAN :
  • Q5T4D3
Family:
  • Belongs to the TMTC family.
Similarity:
  • Contains 8 TPR repeats.
genes like me logo Genes that share domains with TMTC4: view

Function for TMTC4 Gene

Gene Ontology (GO) - Molecular Function for TMTC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042802 identical protein binding --
genes like me logo Genes that share ontologies with TMTC4: view

Animal Model Products

miRNA for TMTC4 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMTC4 Gene

Localization for TMTC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMTC4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMTC4 Gene COMPARTMENTS Subcellular localization image for TMTC4 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMTC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMTC4: view

Pathways for TMTC4 Gene

SuperPathways for TMTC4 Gene

No Data Available

Interacting Proteins for TMTC4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343871%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000343871 Q5T4D3-TMTC4_HUMAN for TMTC4 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMTC4 Gene

None

No data available for Pathways by source for TMTC4 Gene

Transcripts for TMTC4 Gene

Unigene Clusters for TMTC4 Gene

Transmembrane and tetratricopeptide repeat containing 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMTC4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMTC4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ·
SP1: - - - -
SP2: - - - - -
SP3: -
SP4:
SP5: - - -
SP6: - -
SP7: - - - - - -
SP8:
SP9: - - -
SP10:
SP11:

ExUns: 18d ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TMTC4 Gene

GeneLoc Exon Structure for
TMTC4
ECgene alternative splicing isoforms for
TMTC4

Expression for TMTC4 Gene

mRNA expression in normal human tissues for TMTC4 Gene

Protein differential expression in normal tissues for TMTC4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (54.8) and Retina (14.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMTC4 Gene

SOURCE GeneReport for Unigene cluster for TMTC4 Gene Hs.190983

genes like me logo Genes that share expressions with TMTC4: view

Expression partners for TMTC4 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMTC4 Gene

Orthologs for TMTC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMTC4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TMTC4 35
  • 88.43 (n)
  • 92.22 (a)
TMTC4 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmtc4 35
  • 88.02 (n)
  • 90.81 (a)
Tmtc4 16
Tmtc4 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMTC4 35
  • 99.22 (n)
  • 99.56 (a)
TMTC4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmtc4 35
  • 87.79 (n)
  • 90.27 (a)
cow
(Bos Taurus)
Mammalia TMTC4 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMTC4 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMTC4 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMTC4 35
  • 77.55 (n)
  • 84.96 (a)
TMTC4 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMTC4 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmtc4 35
  • 71.33 (n)
  • 75.82 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
tmtc4 35
  • 67.26 (n)
  • 69.6 (a)
tmtc4 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003363 35
  • 48.68 (n)
  • 41.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5038 35
  • 50.46 (n)
  • 39.6 (a)
CG5038 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F38B6.6 35
  • 48.34 (n)
  • 40.65 (a)
F38B6.6 36
  • 36 (a)
OneToOne
Species with no ortholog for TMTC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMTC4 Gene

ENSEMBL:
Gene Tree for TMTC4 (if available)
TreeFam:
Gene Tree for TMTC4 (if available)

Paralogs for TMTC4 Gene

Paralogs for TMTC4 Gene

Selected SIMAP similar genes for TMTC4 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TMTC4 Gene

genes like me logo Genes that share paralogs with TMTC4: view

Variants for TMTC4 Gene

Sequence variations from dbSNP and Humsavar for TMTC4 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs945962 -- 100,665,882(-) GGGGA(A/G)TGGTC intron-variant
rs946133 -- 100,611,235(+) AAGAA(A/G)CGACT intron-variant
rs946837 - 100,635,086(+) CCCAA(C/T)GCTGG missense, reference
rs946838 -- 100,635,111(+) CGCTC(C/T)GCGAC reference, synonymous-codon
rs946839 -- 100,635,397(+) TCCTC(C/T)GGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMTC4 Gene

Variant ID Type Subtype PubMed ID
nsv7247 OTHER Inversion 18451855
nsv522365 CNV Loss 19592680
nsv900959 CNV Gain 21882294

Relevant External Links for TMTC4 Gene

HapMap Linkage Disequilibrium report
TMTC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMTC4 Gene

Disorders for TMTC4 Gene

Relevant External Links for TMTC4

Genetic Association Database (GAD)
TMTC4

No disorders were found for TMTC4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TMTC4 Gene

Publications for TMTC4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Human ORFeome version 1.1: a platform for reverse proteomics. (PMID: 15489335) Rual J.F. … Vidal M. (Genome Res. 2004) 3
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3

Products for TMTC4 Gene

Sources for TMTC4 Gene

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