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Aliases for TMTC4 Gene

Aliases for TMTC4 Gene

  • Transmembrane And Tetratricopeptide Repeat Containing 4 2 3 5

External Ids for TMTC4 Gene

Previous GeneCards Identifiers for TMTC4 Gene

  • GC13M100055
  • GC13M101256
  • GC13M081852

Summaries for TMTC4 Gene

GeneCards Summary for TMTC4 Gene

TMTC4 (Transmembrane And Tetratricopeptide Repeat Containing 4) is a Protein Coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is TMTC3.

Gene Wiki entry for TMTC4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMTC4 Gene

Genomics for TMTC4 Gene

Regulatory Elements for TMTC4 Gene

Promoters for TMTC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMTC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMTC4 Gene

100,603,836 bp from pter
100,675,093 bp from pter
71,258 bases
Minus strand

Genomic View for TMTC4 Gene

Genes around TMTC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMTC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMTC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMTC4 Gene

Proteins for TMTC4 Gene

  • Protein details for TMTC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and TPR repeat-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • A6NLI7
    • B7Z666
    • Q5T4D4
    • Q5T4D5
    • Q5T4D6
    • Q8WV63
    • Q96SU8

    Protein attributes for TMTC4 Gene

    741 amino acids
    Molecular mass:
    82991 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH18707.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AK056409; Type=Frameshift; Positions=268; Evidence={ECO:0000305}; Sequence=BAB55179.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI11004.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI11005.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI11006.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMTC4 Gene


neXtProt entry for TMTC4 Gene

Proteomics data for TMTC4 Gene at MOPED

Post-translational modifications for TMTC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMTC4 Gene

Domains & Families for TMTC4 Gene

Gene Families for TMTC4 Gene

Protein Domains for TMTC4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMTC family.
  • Contains 8 TPR repeats.
  • Belongs to the TMTC family.
  • Contains 8 TPR repeats.
genes like me logo Genes that share domains with TMTC4: view

Function for TMTC4 Gene

Phenotypes for TMTC4 Gene

GenomeRNAi human phenotypes for TMTC4:
genes like me logo Genes that share phenotypes with TMTC4: view

Animal Model Products

miRNA for TMTC4 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMTC4 Gene

Localization for TMTC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMTC4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMTC4 Gene COMPARTMENTS Subcellular localization image for TMTC4 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TMTC4 Gene

Pathways & Interactions for TMTC4 Gene

SuperPathways for TMTC4 Gene

No Data Available

Interacting Proteins for TMTC4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q5T4D3-TMTC4_HUMAN ENSP00000343871 for TMTC4 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TMTC4 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMTC4 Gene

Drugs & Compounds for TMTC4 Gene

No Compound Related Data Available

Transcripts for TMTC4 Gene

Unigene Clusters for TMTC4 Gene

Transmembrane and tetratricopeptide repeat containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMTC4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ·
SP1: - - - -
SP2: - - - - -
SP3: -
SP5: - - -
SP6: - -
SP7: - - - - - -
SP9: - - -

ExUns: 18d ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23
SP1: - -
SP2: - -

Relevant External Links for TMTC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMTC4 Gene

mRNA expression in normal human tissues for TMTC4 Gene

Protein differential expression in normal tissues from HIPED for TMTC4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (54.8) and Retina (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMTC4 Gene

SOURCE GeneReport for Unigene cluster for TMTC4 Gene Hs.190983

genes like me logo Genes that share expression patterns with TMTC4: view

Protein tissue co-expression partners for TMTC4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMTC4 Gene

Orthologs for TMTC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMTC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TMTC4 35
  • 88.43 (n)
  • 92.22 (a)
TMTC4 36
  • 82 (a)
(Mus musculus)
Mammalia Tmtc4 35
  • 88.02 (n)
  • 90.81 (a)
Tmtc4 16
Tmtc4 36
  • 91 (a)
(Pan troglodytes)
Mammalia TMTC4 35
  • 99.22 (n)
  • 99.56 (a)
TMTC4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmtc4 35
  • 87.79 (n)
  • 90.27 (a)
(Bos Taurus)
Mammalia TMTC4 36
  • 91 (a)
(Monodelphis domestica)
Mammalia TMTC4 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia TMTC4 36
  • 80 (a)
(Gallus gallus)
Aves TMTC4 35
  • 77.55 (n)
  • 84.96 (a)
TMTC4 36
  • 85 (a)
(Anolis carolinensis)
Reptilia TMTC4 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmtc4 35
  • 71.33 (n)
  • 75.82 (a)
(Danio rerio)
Actinopterygii -- 35
tmtc4 35
  • 67.26 (n)
  • 69.6 (a)
tmtc4 36
  • 69 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003363 35
  • 48.68 (n)
  • 41.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5038 35
  • 50.46 (n)
  • 39.6 (a)
CG5038 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea F38B6.6 35
  • 48.34 (n)
  • 40.65 (a)
F38B6.6 36
  • 36 (a)
Species with no ortholog for TMTC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMTC4 Gene

Gene Tree for TMTC4 (if available)
Gene Tree for TMTC4 (if available)

Paralogs for TMTC4 Gene

Paralogs for TMTC4 Gene

(3) SIMAP similar genes for TMTC4 Gene using alignment to 4 proteins: Pseudogenes for TMTC4 Gene

genes like me logo Genes that share paralogs with TMTC4: view

Variants for TMTC4 Gene

Sequence variations from dbSNP and Humsavar for TMTC4 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs3809371 - 100,637,624(+) GCGCA(C/G/T)GTAGA reference, missense
rs946837 - 100,635,086(+) CCCAA(C/T)GCTGG reference, missense
VAR_036455 A breast cancer sample
rs945962 -- 100,665,882(-) GGGGA(A/G)TGGTC intron-variant
rs946838 -- 100,635,111(+) CGCTC(C/T)GCGAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TMTC4 Gene

Variant ID Type Subtype PubMed ID
nsv7247 OTHER Inversion 18451855
nsv522365 CNV Loss 19592680
nsv900959 CNV Gain 21882294

Variation tolerance for TMTC4 Gene

Residual Variation Intolerance Score: 8.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.37; 63.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMTC4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMTC4 Gene

Disorders for TMTC4 Gene

Relevant External Links for TMTC4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMTC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMTC4 Gene

Publications for TMTC4 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TMTC4 Gene

Sources for TMTC4 Gene

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