Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMTC3 Gene

Aliases for TMTC3 Gene

  • Transmembrane And Tetratricopeptide Repeat Containing 3 2 3
  • Transmembrane And TPR Repeat-Containing Protein 3 3
  • Protein SMILE 4
  • SMILE 3

External Ids for TMTC3 Gene

Summaries for TMTC3 Gene

Entrez Gene Summary for TMTC3 Gene

  • This gene encodes a protein that belongs to the transmembrane and tetratricopeptide repeat-containing protein family. [provided by RefSeq, May 2010]

GeneCards Summary for TMTC3 Gene

TMTC3 is a Protein Coding gene. An important paralog of this gene is TMTC2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMTC3 Gene

Genomics for TMTC3 Gene

Genomic Location for TMTC3 Gene

88,142,296 bp from pter
88,199,887 bp from pter
57,592 bases
Plus strand

Genomic View for TMTC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMTC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMTC3 Gene

Regulatory Elements for TMTC3 Gene

Proteins for TMTC3 Gene

  • Protein details for TMTC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and TPR repeat-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • Q5CZ86
    • Q5H9T6
    • Q68DQ6
    • Q68DX0
    • Q7Z332
    • Q8NC50

    Protein attributes for TMTC3 Gene

    915 amino acids
    Molecular mass:
    104009 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11325.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMTC3 Gene


neXtProt entry for TMTC3 Gene

Proteomics data for TMTC3 Gene at MOPED

Post-translational modifications for TMTC3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys460 and Lys738
  • Glycosylation at Asn117, Asn494, Asn541, and Thr844

Other Protein References for TMTC3 Gene

No data available for DME Specific Peptides for TMTC3 Gene

Domains for TMTC3 Gene

Gene Families for TMTC3 Gene

  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for TMTC3 Gene


  • Belongs to the TMTC family.:
    • Q6ZXV5
  • Contains 10 TPR repeats.:
    • Q6ZXV5
genes like me logo Genes that share domains with TMTC3: view

Function for TMTC3 Gene

Gene Ontology (GO) - Molecular Function for TMTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMTC3: view
genes like me logo Genes that share phenotypes with TMTC3: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMTC3 Gene

Localization for TMTC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMTC3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMTC3 Gene COMPARTMENTS Subcellular localization image for TMTC3 gene
Compartment Confidence
cytoskeleton 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMTC3: view

Pathways for TMTC3 Gene

SuperPathways for TMTC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009791 post-embryonic development IEA --
GO:0010468 regulation of gene expression IEA --
GO:0030154 cell differentiation --
GO:0030324 lung development --
GO:0048286 lung alveolus development IEA --
genes like me logo Genes that share ontologies with TMTC3: view

No data available for Pathways by source for TMTC3 Gene

Transcripts for TMTC3 Gene

Unigene Clusters for TMTC3 Gene

Transmembrane and tetratricopeptide repeat containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMTC3 Gene

No ASD Table

Relevant External Links for TMTC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMTC3 Gene

mRNA expression in normal human tissues for TMTC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMTC3 Gene

SOURCE GeneReport for Unigene cluster for TMTC3 Gene Hs.331268

genes like me logo Genes that share expressions with TMTC3: view

Orthologs for TMTC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMTC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMTC3 36
  • 99.78 (n)
  • 99.89 (a)
TMTC3 37
  • 100 (a)
(Bos Taurus)
Mammalia TMTC3 36
  • 92.38 (n)
  • 93.33 (a)
TMTC3 37
  • 93 (a)
(Canis familiaris)
Mammalia TMTC3 36
  • 93.29 (n)
  • 93.98 (a)
TMTC3 37
  • 94 (a)
(Mus musculus)
Mammalia Tmtc3 36
  • 85.54 (n)
  • 90.58 (a)
Tmtc3 16
Tmtc3 37
  • 90 (a)
(Monodelphis domestica)
Mammalia TMTC3 37
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia TMTC3 37
  • 83 (a)
(Rattus norvegicus)
Mammalia Tmtc3 36
  • 86.67 (n)
  • 90.91 (a)
(Gallus gallus)
Aves TMTC3 36
  • 78.44 (n)
  • 84.43 (a)
TMTC3 37
  • 82 (a)
(Anolis carolinensis)
Reptilia TMTC3 37
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10499 36
(Danio rerio)
Actinopterygii tmtc3 36
  • 66.45 (n)
  • 73.71 (a)
tmtc3 37
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010599 36
  • 56.36 (n)
  • 57.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4050 36
  • 53.84 (n)
  • 54.28 (a)
CG4050 37
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
Species with no ortholog for TMTC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMTC3 Gene

Gene Tree for TMTC3 (if available)
Gene Tree for TMTC3 (if available)

Paralogs for TMTC3 Gene

Paralogs for TMTC3 Gene

Selected SIMAP similar genes for TMTC3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMTC3: view

Variants for TMTC3 Gene

Sequence variations from dbSNP and Humsavar for TMTC3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1129136 -- 88,198,616(+) TTTAC(C/T)TTTAT utr-variant-3-prime
rs1129137 -- 88,198,910(+) CGCCA(A/G)CCATT utr-variant-3-prime
rs2468223 -- 88,144,858(+) ATATT(C/T)TTGAG intron-variant
rs2468224 -- 88,145,661(+) ATCTA(C/T)GTGTT intron-variant
rs2468225 -- 88,146,422(+) AAGCC(C/T)AAGAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMTC3 Gene

Variant ID Type Subtype PubMed ID
nsv899418 CNV Gain 21882294
nsv807 CNV Loss 18451855
esv272210 CNV Insertion 20981092
nsv826471 CNV Loss 20364138
nsv826472 CNV Gain 20364138

Relevant External Links for TMTC3 Gene

HapMap Linkage Disequilibrium report

Disorders for TMTC3 Gene

No disorders were found for TMTC3 Gene.

No data available for UniProtKB/Swiss-Prot for TMTC3 Gene

Publications for TMTC3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  4. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TMTC3 Gene

Sources for TMTC3 Gene

Back to Top