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TMTC1 Gene

protein-coding   GIFtS: 50
GCID: GC12M029653

Transmembrane And Tetratricopeptide Repeat Containing 1

  See TMTC1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane And Tetratricopeptide Repeat Containing 11 2
OLF2
TMTC1A2
Transmembrane And Tetratricopeptide Repeat Containing 1A2
Transmembrane And TPR Repeat-Containing Protein 12

External Ids:    HGNC: 240991   Entrez Gene: 838572   Ensembl: ENSG000001336877   UniProtKB: Q8IUR53   

Export aliases for TMTC1 gene to outside databases

Previous GC identifers: GC12M029551 GC12M029547 GC12M029548 GC12M029549 GC12M029422


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMTC1 Gene:
TMTC1 (transmembrane and tetratricopeptide repeat containing 1) is a protein-coding gene. Diseases associated with TMTC1 include diffuse idiopathic skeletal hyperostosis, and spinal cord disease. An important paralog of this gene is TMTC3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMTC1 gene promoter:
         HFH-3   Sp1   CUTL1   Roaz   FOXI1   PPAR-alpha   MEF-2A   Nkx6-1   SEF-1 (1)   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TMTC1 promoter sequence
   Search Chromatin IP Primers for TMTC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMTC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.22   Ensembl cytogenetic band:  12p11.22   HGNC cytogenetic band: 12p11.22

TMTC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMTC1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M029653:  view genomic region     (about GC identifiers)

Start:
29,653,746 bp from pter      End:
29,937,692 bp from pter
Size:
283,947 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TMTC1_HUMAN, Q8IUR5 (See protein sequence)
Recommended Name: Transmembrane and TPR repeat-containing protein 1  
Size: 882 amino acids; 98847 Da
Subunit: May interact with FAM168B
Sequence caution: Sequence=AAK32121.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: D0EP37 F5H8B5 Q6PIU4 Q6ZSM5 Q96N52 Q9BXM2
Alternative splicing: 5 isoforms:  Q8IUR5-5   Q8IUR5-1   Q8IUR5-2   Q8IUR5-3   Q8IUR5-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMTC1: NX_Q8IUR5

Explore proteomics data for TMTC1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn76

  • See TMTC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180380.1  NP_787057.2  

    ENSEMBL proteins: 
     ENSP00000256062   ENSP00000448112   ENSP00000449043   ENSP00000442046   ENSP00000449054  
     ENSP00000370622  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5 InterPro protein domains:
     IPR001440 TPR_1
     IPR011990 TPR-like_helical
     IPR013618 DUF1736
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q8IUR5

    ProtoNet protein and cluster: Q8IUR5

    UniProtKB/Swiss-Prot: TMTC1_HUMAN, Q8IUR5
    Similarity: Belongs to the TMTC family
    Similarity: Contains 10 TPR repeats


    Find genes that share domains with TMTC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TMTC1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TMTC1:
     Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMTC1
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    Selected qRT-PCR Assays for microRNAs that regulate TMTC1 (see all 60):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-136 hsa-miR-520f hsa-miR-607 hsa-miR-106a hsa-miR-548k hsa-miR-200a
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMTC1_HUMAN, Q8IUR5: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMTC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMTC1
    Interactions:

        Search GeneGlobe Interaction Network for TMTC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for TMTC1 (Q8IUR52 ENSP000002560624) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUVBL1ENSP000003182974STRING: ENSP00000318297
    RUVBL2ENSP000002214134STRING: ENSP00000221413
    DNAAF2ENSP000002982924STRING: ENSP00000298292
    PIH1D1ENSP000002622654STRING: ENSP00000262265
    PIH1D2ENSP000002803504STRING: ENSP00000280350
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing ----

    Find genes that share ontologies with TMTC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMTC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMTC1 gene (2 alternative transcripts): 
    NM_001193451.1  NM_175861.3  

    Unigene Cluster for TMTC1:

    Transmembrane and tetratricopeptide repeat containing 1
    Hs.401954  [show with all ESTs]
    Unigene Representative Sequence: NM_175861
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256062(uc001riy.3 uc001riz.3 uc001rja.3 uc021qwi.1 uc001rjb.3)
    ENST00000551659 ENST00000552618 ENST00000552925 ENST00000319685 ENST00000539277
    ENST00000553189(uc001rjc.1) ENST00000550354 ENST00000546582 ENST00000381224

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    Selected qRT-PCR Assays for microRNAs that regulate TMTC1 (see all 60):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-136 hsa-miR-520f hsa-miR-607 hsa-miR-106a hsa-miR-548k hsa-miR-200a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector (see all 2): TMTC1 (NM_175861)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMTC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMTC1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMTC1
      QuantiTect SYBR Green Assays in human, mouse, rat TMTC1
      QuantiFast Probe-based Assays in human, mouse, rat TMTC1

    Additional mRNA sequence: 

    AF319520.1 AF433169.1 AK022989.1 AK055962.1 AK123619.1 AL832328.1 BC007383.2 BC017984.1 
    BC028716.2 BC039460.1 BC042083.1 GQ865601.1 

    12 DOTS entries:

    DT.95364334  DT.100026918  DT.100789829  DT.100665119  DT.115190  DT.103488  DT.99979693  DT.121177362 
    DT.121177367  DT.65286256  DT.121177372  DT.75157276 

    Selected AceView cDNA sequences (see all 233):

    CA425811 AA446877 AA625277 BQ008488 AA447480 N36601 BE463574 BC039460 
    N41490 AI240733 BM997080 AW338002 BG771401 CB243606 AA902571 BF792441 
    BF109231 C00626 CA388717 AA954340 AI057635 AI417542 CA390305 BE674387 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMTC1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
    SP1:        -     -                             -     -     -                                         -           -                                             
    SP2:                                                        -                                         -           -                                             
    SP3:                                                                                                  -           -                                             
    SP4:                                                        -                                                                                                   
    SP5:                                                                                                                          -                                 


    ECgene alternative splicing isoforms for TMTC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMTC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCCGCCTG
    TMTC1 Expression
    About this image


    TMTC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
    TMTC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMTC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.401954
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMTC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMTC1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmtc11 , 5 transmembrane and tetratricopeptide repeat containing more1, 5 83.56(n)1
    87.39(a)1
      6 (78.49 cM)5
    3873141  NM_198967.51  NP_945318.21 
     1482324305 
    chicken
    (Gallus gallus)
    Aves TMTC11 transmembrane and tetratricopeptide repeat containing more 75.35(n)
    80.08(a)
      418143  XM_004937905.1  XP_004937962.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMTC16
    transmembrane and tetratricopeptide repeat contain...
    73(a)
    1 ↔ 1
    5(10997103-11161131)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmtc11 transmembrane and tetratricopeptide repeat containing more 63.32(n)
    62.39(a)
      100498549  XM_002942252.2  XP_002942298.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5554491 transmembrane and TPR repeat-containing protein 1-like 64.18(n)
    66.04(a)
      555449  XM_001921990.4  XP_001922025.3 


    ENSEMBL Gene Tree for TMTC1 (if available)
    TreeFam Gene Tree for TMTC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMTC1 gene
    TMTC32  TMTC22  OGT2  TMTC42  
    3 SIMAP similar genes for TMTC1 using alignment to 4 protein entries:     TMTC1_HUMAN (see all proteins):
    TMTC3    TMTC4    TMTC2

    Find genes that share paralogs with TMTC1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for TMTC1
    PGOHUM00000258619 PGOHUM00000258669 PGOHUM00000239717


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMTC1 (see all 6492)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452521881,2
    --29653303(+) ACAAAC/TTGACA 2 -- int10--------
    rs8228761,2
    C,F,O,A,H--29653718(-) TGTCCA/GTGTCA 2 -- int128Minor allele frequency- G:0.17NS EA NA CSA WA 2964
    rs110502601,2
    C,F,H--29653741(+) AACCAT/AGAAGT 2 -- int117Minor allele frequency- A:0.09NS EA NA 2128
    rs1476038181,2
    --29653779(+) TATTTA/TAATCA 2 -- ut310--------
    rs1399813151,2
    C--29653813(+) ACATAA/CATTTA 2 -- ut310--------
    rs1454462771,2
    --29653842(+) CAAAGA/TATACA 2 -- ut310--------
    rs93761,2
    C,F,O,H--29653882(-) TTTATC/GTTCCA 2 -- ut317Minor allele frequency- G:0.08MN NS NA EA 668
    rs2020325851,2
    C--29653885(+) AGATA-/AG/GA 
            
    AATTC
    4 -- ut310--------
    rs1464456751,2
    --29653887(+) ATAAA-/ATTTCTA 2 -- ut310--------
    rs1148500711,2
    F--29653895(+) CTAACG/AGGCAC 2 -- ut311Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for TMTC1 (29653746 - 29903746 bp, first 250kb of TMTC1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TMTC1 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745689CNV Deletion23290073
    esv2745688CNV Deletion23290073
    dgv273e199CNV Deletion23128226
    esv1790446CNV Insertion17803354
    nsv507636CNV Insertion20534489
    esv268514CNV Insertion20981092
    esv269343CNV Insertion20981092
    nsv898953CNV Loss21882294
    nsv498785CNV Loss21111241
    nsv826292CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for TMTC1:    
    About MalaCards
    diffuse idiopathic skeletal hyperostosis    spinal cord disease    radiculopathy

    3 diseases from the University of Copenhagen DISEASES database for TMTC1:
    Spinal cord disease     Diffuse idiopathic skeletal hyperostosis     Radiculopathy

    Find genes that share disorders with TMTC1           About GenesLikeMe

    Genetic Association Database (GAD): TMTC1
    Human Genome Epidemiology (HuGE) Navigator: TMTC1 (7 documents)

    Export disorders for TMTC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMTC1 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with TMTC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Genome-wide association study of multiplex schizophrenia pedigrees. (PubMed id 22885689)1 Levinson D.F....Holmans P.A. (Am J Psychiatry 2012)
    7. Characterizing the neurite outgrowth inhibitory effect of Mani. (PubMed id 22771904)2 Mishra M.... Heese K. (FEBS Lett. 2012)
    8. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. (PubMed id 20445134)1 Smith N.L....Vasan R.S. (Circ Cardiovasc Genet 2010)
    9. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 83857 HGNC: 24099 AceView: ARG99 Ensembl:ENSG00000133687 euGenes: HUgn83857
    ECgene: TMTC1 H-InvDB: TMTC1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMTC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TMTC1 gene:
    Search GeneIP for patents involving TMTC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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