Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMTC1 Gene

protein-coding GIFtS: 47
GCID: GC12M029653

transmembrane and tetratricopeptide repeat containing 1

Explore 5 diseases affiliated with
TMTC1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane And Tetratricopeptide Repeat Containing 1¹ ²		FLJ41625¹
OLF¹ ²		TMTC1A²
ARG99¹		Transmembrane And Tetratricopeptide Repeat Containing 1A²
FLJ31400¹		Transmembrane And TPR Repeat-Containing Protein 1²

External Ids:	HGNC: 24099¹	Entrez Gene: 83857²	Ensembl: ENSG00000133687⁷	UniProtKB: Q8IUR5³

Export aliases for TMTC1 gene to outside databases

Previous GC identifers: GC12M029551 GC12M029547 GC12M029548 GC12M029549 GC12M029422

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMTC1 gene promoter:
HFH-3 Sp1 CUTL1 Roaz FOXI1 PPAR-alpha MEF-2A Nkx6-1 SEF-1 (1) aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TMTC1 promoter sequence

Search SABiosciences Chromatin IP Primers for TMTC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMTC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.22 Ensembl cytogenetic band: 12p11.22 HGNC cytogenetic band: 12p11.22

TMTC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMTC1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M029653: view genomic region (about GC identifiers)

Start:	29,653,746 bp from pter	End:	29,937,692 bp from pter
Size:	283,947 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TMTC1_HUMAN, Q8IUR5 (See protein sequence)

Recommended Name: Transmembrane and TPR repeat-containing protein 1

Size: 882 amino acids; 98847 Da

Subunit: May interact with FAM168B

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Sequence caution: Sequence=AAK32121.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: D0EP37 F5H8B5 Q6PIU4 Q6ZSM5 Q96N52 Q9BXM2

Alternative splicing: 5 isoforms: Q8IUR5-5 Q8IUR5-1 Q8IUR5-2 Q8IUR5-3 Q8IUR5-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMTC1: NX_Q8IUR5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IUR5

TMTC1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001180380.1 NP_787057.2

ENSEMBL proteins:

ENSP00000256062 ENSP00000448112 ENSP00000449043 ENSP00000442046 ENSP00000449054

ENSP00000370622

Human Recombinant Protein Products for TMTC1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TMTC1 OriGene Custom Protein Services for TMTC1
	GenScript Custom Purified and Recombinant Proteins Services for TMTC1
	Novus Biologicals TMTC1 Protein Novus Biologicals TMTC1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TMTC1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0016021	integral to membrane	IEA	--

TMTC1 for ontologies About GeneDecksing

TMTC1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for TMTC1
	GenScript Custom Superior Antibodies Services for TMTC1
	Novus Biologicals TMTC1 Antibodies
	Abcam antibodies for TMTC1
	Uscn Antibodies for TMTC1
	Search ThermoFisher Antibodies for TMTC1

Assay Products for TMTC1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TMTC1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TMTC1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMTC1 for domains About GeneDecksing

5 InterPro domains/families:

IPR001440 TPR-1

IPR011990 TPR-like_helical

IPR013618 DUF1736

IPR013026 TPR-contain_dom

IPR019734 TPR_repeat

Graphical View of Domain Structure for InterPro Entry Q8IUR5

ProtoNet protein and cluster: Q8IUR5

UniProtKB/Swiss-Prot: TMTC1_HUMAN, Q8IUR5

Similarity: Belongs to the TMTC family

Similarity: Contains 10 TPR repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
1 GenomeRNAi human phenotype for TMTC1:

Decreased p24 protein expressi

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TMTC1

miRNA Products:		OriGene 3'-UTR Clone: TMTC1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMTC1
		8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate TMTC1 (see all 60):
		hsa-miR-142-5p hsa-miR-548j hsa-miR-136 hsa-miR-520f hsa-miR-607 hsa-miR-106a hsa-miR-548k hsa-miR-200a

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMTC1 (see all 4) OriGene shRNA RFP: TMTC1 OriGene siRNA: TMTC1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMTC1
		Sirion Biotech Custom design and validation of potent shRNA sequences against TMTC1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TMTC1
			Sirion Biotech Customized adenovirus for overexpression of TMTC1 Sirion Biotech Customized adenovirus for potent knockdown of TMTC1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMTC1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMTC1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TMTC1 (NM_175861)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMTC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMTC1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TMTC1
		Search LifeMap BioReagents cell lines for TMTC1
		Sirion Biotech Customized stable knockdown cell line services for TMTC1 Sirion Biotech Customized inducible knockdown cell line services for TMTC1 Sirion Biotech Customized stable overexpressing cell line services for TMTC1 Sirion Biotech Customized inducible overexpressing cell line services for TMTC1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMTC1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMTC1

1 Interacting protein for TMTC1 (Q8IUR5²) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
--	D4AEP3²	MINT-8383606

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMTC1
Search CenterWatch for drugs/clinical trials and news about TMTC1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMTC1 gene (2 alternative transcripts):

NM_001193451.1 NM_175861.3

Unigene Cluster for TMTC1:

Transmembrane and tetratricopeptide repeat containing 1

Hs.401954 [show with all ESTs]

Unigene Representative Sequence: NM_175861

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000256062(uc001riy.3 uc001riz.3 uc001rja.3 uc021qwi.1 uc001rjb.3)

ENST00000551659 ENST00000552618 ENST00000552925 ENST00000319685 ENST00000539277

ENST00000553189(uc001rjc.1) ENST00000550354 ENST00000546582 ENST00000381224

miRNA Products:		OriGene 3'-UTR Clone: TMTC1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMTC1
		8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate TMTC1 (see all 60):
		hsa-miR-142-5p hsa-miR-548j hsa-miR-136 hsa-miR-520f hsa-miR-607 hsa-miR-106a hsa-miR-548k hsa-miR-200a

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMTC1 (see all 4) OriGene shRNA RFP: TMTC1 OriGene siRNA: TMTC1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMTC1
		Sirion Biotech Custom design and validation of potent shRNA sequences against TMTC1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMTC1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMTC1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TMTC1 (NM_175861)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMTC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMTC1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMTC1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMTC1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMTC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMTC1

Additional cDNA sequence:

AF319520.1 AF433169.1 AK022989.1 AK055962.1 AK123619.1 AL832328.1 BC007383.2 BC017984.1

BC028716.2 BC039460.1 BC042083.1 GQ865601.1

12 DOTS entries:

DT.95364334 DT.100026918 DT.100789829 DT.100665119 DT.115190 DT.103488 DT.99979693 DT.121177362

DT.121177367 DT.65286256 DT.121177372 DT.75157276

24/233 AceView cDNA sequences (see all 233):

BU623454 BE221202 BQ008488 C00626 AI468551 AI262824 AI290567 BC039460

AA447480 AA954340 BM919954 AI417542 AI084511 BE674387 AW410262 BG779904

BM997080 AI240733 BC017984 AI202991 NM_175861 AI057635 BG771401 BE669613

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TMTC1 (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19a	·	19b	^	20	^	21	^	22	^	23	^	24
SP1:			-		-										-		-		-														-				-
SP2:																			-														-				-
SP3:																																	-				-
SP4:																			-
SP5:																																									-

ECgene alternative splicing isoforms for TMTC1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMTC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCCGCCTG

About this image

TMTC1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Medulla Oblongata

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

See TMTC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMTC1

SOURCE GeneReport for Unigene cluster: Hs.401954

SABiosciences Custom PCR Arrays for TMTC1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMTC1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMTC1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMTC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMTC1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMTC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TMTC1 gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TMTC1¹	transmembrane and tetratricopeptide repeat containing more	75.6(n) 80.67(a)		418143 XM_416374.3 XP_416374.3
lizard (Anolis carolinensis)	Reptilia	TMTC1⁶	--	71(a)	1 ↔ 1	5(10997103-11161129)
zebrafish (Danio rerio)	Actinopterygii	LOC555449¹	similar to ARG99 protein	64.94(n) 66.94(a)		555449 XM_001921990.3 XP_001922025.3
honey bee (Apis mellifera)	Insecta	--	--	28(a)	1 ↔ 1	Group6.8(78757-275431)

ENSEMBL Gene Tree for TMTC1 (if available)
TreeFam Gene Tree for TMTC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMTC1 gene

TMTC3² TMTC2² OGT² TMTC4²

3 SIMAP similar genes for TMTC1 using alignment to 4 protein entries: TMTC1_HUMAN (see all proteins):

TMTC3 TMTC2 TMTC4

TMTC1 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for TMTC1
PGOHUM00000258619 PGOHUM00000258669 PGOHUM00000239717

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145252188^1,2		--	29653303(+)	`ACAAAC/TTGACA`	2	--	int¹		0	--	--	--	--
rs822876^1,2	C,F,O,A,H	--	29653718(-)	`TGTCCA/GTGTCA`	2	--	int¹		28		NS EA NA CSA WA	2964
rs11050260^1,2	C,F,H	--	29653741(+)	`AACCAT/AGAAGT`	2	--	int¹		17		NS EA NA	2128
rs147603818^1,2		--	29653779(+)	`TATTTA/TAATCA`	2	--	ut3¹		0	--	--	--	--
rs139981315^1,2		--	29653813(+)	`ACATAA/CATTTA`	2	--	ut3¹		0	--	--	--	--
rs145446277^1,2		--	29653842(+)	`CAAAGA/TATACA`	2	--	ut3¹		0	--	--	--	--
rs9376^1,2	C,F,O,H	--	29653882(-)	`TTTATC/GTTCCA`	2	--	ut3¹		7		MN NS NA EA	668
rs146445675^1,2		--	29653887(+)	`ATAAA-/ATTTCTA`	2	--	ut3¹		0	--	--	--	--
rs114850071^1,2	F	--	29653895(+)	`CTAACG/AGGCAC`	2	--	ut3¹		1		WA	118
rs68017043^1,2	C	--	29653900(+)	`NNNNAC/AAGCCA`	2	--	ut3¹		3		WA NA	240

HapMap Linkage Disequilibrium report for TMTC1 (29653746 - 29903746 bp, first 250kb of TMTC1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TMTC1
3 CNVs: 86288 61220 66171

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMTC1

DNA2.0 Custom Variant and Variant Library Synthesis for TMTC1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMTC1 for disorders About GeneDecksing

5 diseases for TMTC1: About MalaCards

diffuse idiopathic skeletal hyperostosis spinal cord disease femoral neuropathy hyperostosis

neuropathy

3 diseases from the University of Copenhagen DISEASES database for TMTC1:

Spinal cord disease Diffuse idiopathic skeletal hyperostosis Radiculopathy

Human Genome Epidemiology (HuGE) Navigator: TMTC1 (7 documents)

Export disorders for TMTC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMTC1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TMTC1)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Genome-wide association study of multiplex schizophren ia pedigrees. (PubMed id 22885689)¹ Levinson D.F....Holmans P.A. (2012)
Characterizing the neurite outgrowth inhibitory effect of Mani. (PubMed id 22771904)² Mishra M.... Heese K. (2012)
Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospecti ve meta-analysis from the cohorts for heart and aging research in genomic epide miology (CHARGE) consortium. (PubMed id 20445134)¹ Smith N.L....Vasan R.S. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PubMed id 17903295)¹ Lunetta K.L....Murabito J.M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83857	HGNC: 24099	AceView: ARG99	Ensembl:ENSG00000133687	euGenes: HUgn83857
ECgene: TMTC1	H-InvDB: TMTC1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMTC1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMTC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMTC1 gene:
Search GeneIP for patents involving TMTC1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for TMTC1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMTC1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMTC1
	OriGene Protein Over-expression Lysate for TMTC1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TMTC1		OriGene 3'-UTR Clone for TMTC1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMTC1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMTC1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TMTC1		OriGene Custom Protein Services for TMTC1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMTC1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMTC1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMTC1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMTC1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMTC1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMTC1

	GenScript Custom Purified and Recombinant Proteins Services for TMTC1		GenScript cDNA clones with any tag delivered in your preferred vector for TMTC1
	GenScript Custom Assay Services for TMTC1		GenScript Custom Superior Antibodies Services for TMTC1
	GenScript Custom overexpressing Cell Line Services for TMTC1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TMTC1 promoter
	Search Chromatin IP Primers for TMTC1
	RT² qPCR Primer Assay in human, mouse, rat TMTC1
	Search GNC Networks for TMTC1
	SABiosciences Custom PCR Arrays for TMTC1

Search Tocris compounds for TMTC1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TMTC1 antibodies
	TMTC1 proteins
	TMTC1 lysates

	Antibodies for TMTC1
	See all of Abcam's Antibodies, Kits and Proteins for TMTC1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TMTC1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TMTC1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMTC1

	Browse SwitchGear 3'UTR luciferase reporter plasmids for TMTC1
	SwitchGear Promoter luciferase reporter plasmids for TMTC1

Search ThermoFisher Antibodies for TMTC1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMTC1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TMTC1

Sirion Biotech Customized:

	stable knockdown cell line services for TMTC1
	inducible knockdown cell line services for TMTC1
	design and validation of potent shRNA sequences against TMTC1
	adenovirus for potent knockdown of TMTC1
	adenovirus for overexpression of TMTC1
	stable overexpressing cell line services for TMTC1
	inducible overexpressing cell line services for TMTC1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TMTC1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

TMTC1 Gene

transmembrane and tetratricopeptide repeat containing 1

Aliases
for TMTC1 gene

Summaries
for TMTC1 gene

Genomic Views
for TMTC1 gene

Proteins
for TMTC1 gene

Protein Domains /
Families
for TMTC1 gene

Function
for TMTC1 gene

Pathways & Interactions
for TMTC1 gene

Drugs & Compounds
for TMTC1 gene

Transcripts
for TMTC1 gene

Expression
for TMTC1 gene

Orthologs
for TMTC1 gene

Paralogs
for TMTC1 gene

Genomic Variants
for TMTC1 gene

Disorders / Diseases
for TMTC1 gene

Publications
for TMTC1 gene

External Searches for TMTC1 gene

Genome Databases showing TMTC1 gene

Other Databases showing TMTC1 gene

Specialized Databases showing TMTC1 gene

Intellectual Property
for TMTC1 gene

Products
for TMTC1 gene

View Random Gene

Advanced Search

Export list of displayed genes

TMTC1 Gene

transmembrane and tetratricopeptide repeat containing 1

Aliasesfor TMTC1 gene

Summariesfor TMTC1 gene

Genomic Viewsfor TMTC1 gene

Proteinsfor TMTC1 gene

Protein Domains /Familiesfor TMTC1 gene

Functionfor TMTC1 gene

Pathways & Interactionsfor TMTC1 gene

Drugs & Compoundsfor TMTC1 gene

Transcriptsfor TMTC1 gene

Expression for TMTC1 gene

Orthologsfor TMTC1 gene

Paralogsfor TMTC1 gene

Genomic Variantsfor TMTC1 gene

Disorders / Diseasesfor TMTC1 gene

Publicationsfor TMTC1 gene

External Searches for TMTC1 gene

Genome Databases showing TMTC1 gene

Other Databases showing TMTC1 gene

Specialized Databases showing TMTC1 gene

Intellectual Propertyfor TMTC1 gene

Productsfor TMTC1 gene

View Random Gene

Aliases
for TMTC1 gene

Summaries
for TMTC1 gene

Genomic Views
for TMTC1 gene

Proteins
for TMTC1 gene

Protein Domains /
Families
for TMTC1 gene

Function
for TMTC1 gene

Pathways & Interactions
for TMTC1 gene

Drugs & Compounds
for TMTC1 gene

Transcripts
for TMTC1 gene

Expression
for TMTC1 gene

Orthologs
for TMTC1 gene

Paralogs
for TMTC1 gene

Genomic Variants
for TMTC1 gene

Disorders / Diseases
for TMTC1 gene

Publications
for TMTC1 gene

Intellectual Property
for TMTC1 gene

Products
for TMTC1 gene