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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMSB4Y Gene

protein-coding   GIFtS: 49
GCID: GC0YP015815

Thymosin Beta 4, Y-Linked

(Previous names: thymosin, beta 4, Y chromosome)
  Search for TMSB4Y
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thymosin Beta 4, Y-Linked1 2
Thymosin, Beta 4, Y Chromosome1 2
TB4Y2 3
Thymosin Beta-4, Y Isoform2
Thymosin Beta-4, Y-Chromosomal2

External Ids:    HGNC: 118821   Entrez Gene: 90872   Ensembl: ENSG000001546207   OMIM: 4000175   UniProtKB: O146043   

Export aliases for TMSB4Y gene to outside databases

Previous GC identifers: GC0YP015133 GC0YP014824 GC0YP014253 GC0YP010461


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMSB4Y Gene:
This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation
and encodes an actin sequestering protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for TMSB4Y Gene: 
TMSB4Y (thymosin beta 4, Y-linked) is a protein-coding gene. Among its related super-pathways are Regulation of Actin Cytoskeleton and MAPK Signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is TMSB15B.

UniProtKB/Swiss-Prot: TYB4Y_HUMAN, O14604
Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers
(G actin) and therefore inhibits actin polymerization (By similarity)

Gene Wiki entry for TMSB4Y (Thymosin beta-4, Y-chromosomal) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000024.9  NT_011875.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMSB4Y gene promoter:
         CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMSB4Y promoter sequence
   Search SABiosciences Chromatin IP Primers for TMSB4Y

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMSB4Y


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yq11.221   Ensembl cytogenetic band:  Yq11.221   HGNC cytogenetic band: Yq11.221

TMSB4Y Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMSB4Y gene location

GeneLoc information about chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YP015815:  view genomic region     (about GC identifiers)

Start:
15,815,447 bp from pter      End:
15,817,904 bp from pter
Size:
2,458 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TYB4Y_HUMAN, O14604 (See protein sequence)
Recommended Name: Thymosin beta-4, Y-chromosomal  
Size: 44 amino acids; 5013 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Secondary accessions: Q0VDA2

Explore the universe of human proteins at neXtProt for TMSB4Y: NX_O14604

Explore proteomics data for TMSB4Y at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14604

  • TMSB4Y Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMSB4Y Protein Expression
    REFSEQ proteins: NP_004193.1  
    ENSEMBL proteins: 
     ENSP00000284856  

    Human Recombinant Protein Products for TMSB4Y: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--
    GO:0005856cytoskeleton IEA--

    TMSB4Y for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001152 Thymosin_b4
     IPR016323 Thymosin_b4_chordata

    Graphical View of Domain Structure for InterPro Entry O14604

    ProtoNet protein and cluster: O14604

    1 Blocks protein domain: IPB001152 Thymosin beta-4

    UniProtKB/Swiss-Prot: TYB4Y_HUMAN, O14604
    Similarity: Belongs to the thymosin beta family


    TMSB4Y for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYB4Y_HUMAN, O14604
    Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers
    (G actin) and therefore inhibits actin polymerization (By similarity)

         Genatlas biochemistry entry for TMSB4Y:
    thymosin-beta 4,identical to the interferon inducible gene 6-26 (4/26),potential actin sequestering
    protein,ubiquitous in a AZF deleted region

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
         
    TMSB4Y for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TMSB4Y About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Actin Cytoskeleton
    Regulation of actin cytoskeleton0.57
    2Rho Family GTPases
    ILK Signaling0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TMSB4Y
        ILK Signaling


    1         Kegg Pathway  (Kegg details for TMSB4Y):
        Regulation of actin cytoskeleton


    TMSB4Y for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMSB4Y

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/10 Interacting proteins for TMSB4Y (O146042, 3 ENSP000002848564) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTA1P681333, ENSP000003556454I2D: score=1 STRING: ENSP00000355645
    ACTG1P632613, ENSP000003315144I2D: score=2 STRING: ENSP00000331514
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    ACTBENSP000003499604STRING: ENSP00000349960
    POT1ENSP000003502494STRING: ENSP00000350249
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization ----
    GO:0008064regulation of actin polymerization or depolymerization TAS8838802
    GO:0030036actin cytoskeleton organization IEA--
    GO:0030334regulation of cell migration IEA--
    GO:0042989sequestering of actin monomers IEA--

    TMSB4Y for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMSB4Y (TYB4Y)

    Search CenterWatch for drugs/clinical trials and news about TMSB4Y / TYB4Y

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMSB4Y gene: 
    NM_004202.2  

    Unigene Cluster for TMSB4Y:

    Thymosin beta 4, Y-linked
    Hs.159201  [show with all ESTs]
    Unigene Representative Sequence: NM_004202
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000284856(uc004ftb.3)
    miRNA
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    hsa-miR-3194-5p hsa-let-7g* hsa-miR-183 hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidTMSB4Y 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF000989.1 BC022482.1 BC119763.1 BC119764.1 

    1 DOTS entry:

    DT.402758 

    17 AceView cDNA sequences:

    NM_004202 BX116941 BF445685 AI365057 BI459652 AF000989 BC022482 N50556 
    N50611 BG772077 BX493896 BG716394 BX493885 AV747044 BE938781 AV750590 
    CD250150 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TMSB4Y    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
    SP1:        -           -               
    SP2:                                    


    ECgene alternative splicing isoforms for TMSB4Y

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMSB4Y expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGTGAGAAG
    TMSB4Y Expression
    About this image


    See TMSB4Y Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMSB4Y

    SOURCE GeneReport for Unigene cluster: Hs.159201

    UniProtKB/Swiss-Prot: TYB4Y_HUMAN, O14604
    Tissue specificity: Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TMSB4Y gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TMSB4X6
    thymosin, beta 4
    93(a)
    possible ortholog
    1(122807092-122808710)
    lizard
    (Anolis carolinensis)
    Reptilia TMSB4Y6
    Uncharacterized protein
    93(a)
    1 ↔ 1
    3(120076414-120077268)
    zebrafish
    (Danio rerio)
    Actinopterygii TMSB15A6
    tmsb6
    (see all 3)
    thymosin, beta
    (see all 3)
    48(a)
    40(a)
    (see all 3)
    1 ↔ many
    possible ortholog
    (see all 3)
    9(56198178-56199762)
    21(25782878-25786220)
            Species with no ortholog for TMSB4Y

    ENSEMBL Gene Tree for TMSB4Y (if available)
    TreeFam Gene Tree for TMSB4Y (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMSB4Y gene
    TMSB15B2  TMSB15A2  TMSB102  TMSB4X2  
    5 SIMAP similar genes for TMSB4Y using alignment to 1 protein entry:     TYB4Y_HUMAN:
    TMSB4X    TMSB15A    TMSB4XP4    TMSB10    TMSB15B

    TMSB4Y for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/44 SNPs in TMSB4Y are shown (see all 44)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr Y posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs15415111,2
    C--15814487(+) GACCCC/TTAAAT 1 -- us2k1 tfbs34Minor allele frequency- T:0.01NA PA 254
    rs97860771,2
    C--15815443(+) GCTGAA/GATGTG 1 -- us2k10--------
    rs133037431,2
    C--15816093(+) GAGGGA/CGAGAA 1 -- ut51 ese30--------
    rs133039671,2
    C--15816094(+) AGGGCA/GAGAAG 1 -- ut51 ese30--------
    rs133059041,2
    C--15816112(+) TCAGGT/CTGCGG 1 -- ut51 ese31Minor allele frequency- C:0.00NA 2
    rs133059051,2
    C--15816113(+) CAGGTG/TGCGGG 1 -- ut51 ese30--------
    rs133038591,2
    C--15816140(+) CAGTTA/CCCAGT 1 -- ut51 ese30--------
    rs133038621,2
    C--15816142(+) GTTCCC/TAGTAC 1 -- ut51 ese30--------
    rs133040891,2
    C--15816157(+) ACCCGA/GACAGG 1 -- ut51 ese30--------
    rs3702768521,2
    ----15815995(+) TCCTCG/TTGGTC 1 -- ut510--------

    HapMap Linkage Disequilibrium report for TMSB4Y (15815447 - 15817904 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMSB4Y: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMSB4Y
    DNA2.0 Custom Variant and Variant Library Synthesis for TMSB4Y

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TMSB4Y for disorders           About MalaCards
    OMIM gene information: 400017    OMIM disorders: --


    TMSB4Y for disorders           About GeneDecksing


    Export disorders for TMSB4Y gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMSB4Y gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with TMSB4Y)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional coherence of the human Y chromosome. (PubMed id 9381176)1, 2, 3 Lahn B.T. and Page D.C. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (2003)
    4. A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene. (PubMed id 15557202)1, 9 Torikai H....Takahashi T. (2004)
    5. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    6. Thymosin beta 4 enhances NK cell cytotoxicity mediate d by ICAM-1. (PubMed id 19369144)1 Lee H.R....Cho D. (2009)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
    10. The mouse thymosin beta 4 gene: structure, promoter identification, and chromosome localization. (PubMed id 8838802)1 Li X....Yin H.L. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9087 HGNC: 11882 AceView: TMSB4Y Ensembl:ENSG00000154620 euGenes: HUgn9087
    ECgene: TMSB4Y Kegg: 9087 H-InvDB: TMSB4Y

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMSB4Y Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMSB4Y gene:
    Search GeneIP for patents involving TMSB4Y

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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