TMSB4Y Gene
protein-coding GIFtS: 51
GCID: GC0YP015815
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thymosin beta 4, Y-linked(Previous names: thymosin, beta 4, Y chromosome )
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Aliases
for TMSB4Y gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thymosin Beta 4, Y-Linked1 2 | | TB4Y1 2 3 | | Thymosin, Beta 4, Y Chromosome1 2 | | Thymosin Beta-4, Y Isoform2 | | Thymosin Beta-4, Y-Chromosomal2 |
Export aliases for TMSB4Y gene to outside databasesPrevious GC identifers: GC0YP015133 GC0YP014824 GC0YP014253 GC0YP010461 |
Summaries
for TMSB4Y gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TMSB4Y:
This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation andencodes an actin sequestering protein. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TYB4Y_HUMAN, O14604Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (Gactin) and therefore inhibits actin polymerization (By similarity)
Gene Wiki entry for TMSB4Y (Thymosin beta-4, Y-chromosomal)
|
Genomic Views
for TMSB4Y gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000024.9 NT_011875.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMSB4Y gene promoter:
CUTL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMSB4Y
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMSB4Y |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Yq11.221 Ensembl cytogenetic band: Yq11.221 HGNC chromosome: YTMSB4Y Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YP015815: view genomic region
(about GC identifiers)
Start:
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15,815,447 bp from pter |
End:
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15,817,904 bp from pter |
Size:
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2,458 bases |
Orientation:
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plus strand |
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Proteins
for TMSB4Y gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TYB4Y_HUMAN, O14604 (See
protein sequence)Recommended Name: Thymosin beta-4, Y-chromosomal Size: 44 amino acids; 5013 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Secondary accessions: Q0VDA2Explore the universe of human proteins at neXtProt for TMSB4Y: NX_O14604
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14604
TMSB4Y Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004193.1
ENSEMBL proteins: ENSP00000284856
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TMSB4Y for ontologies About GeneDecksing
TMSB4Y Antibody Products:
Assay Products for TMSB4Y: |
Protein
Domains /
Families
for TMSB4Y gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMSB4Y for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O14604ProtoNet protein and cluster: O14604 1 Blocks protein family: IPB001152 Thymosin beta-4
UniProtKB/Swiss-Prot: TYB4Y_HUMAN, O14604Similarity: Belongs to the thymosin beta family |
Function
for TMSB4Y gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TYB4Y_HUMAN, O14604Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (Gactin) and therefore inhibits actin polymerization (By similarity) Genatlas biochemistry entry for TMSB4Y:thymosin-beta 4,identical to the interferon inducible gene 6-26 (4/26),potential actin sequestering protein,ubiquitousin a AZF deleted region
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMSB4Y
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMSB4Y
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMSB4Y |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003779 | actin binding |
IEA | -- |
TMSB4Y for ontologies About GeneDecksing
|
Pathways & Interactions
for TMSB4Y gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of Actin Cytoskeleton | | | 2 | Rho Family GTPases | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TMSB4Y
1 
Kegg Pathway (Kegg details for TMSB4Y):
TMSB4Y for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMSB4Y
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/10 Interacting proteins for TMSB4Y (O146042, 3 ENSP000002848564) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008064 | regulation of actin polymerization or depolymerization |
TAS | 8838802 | | GO:0030036 | actin cytoskeleton organization |
IEA | -- | | GO:0030334 | regulation of cell migration |
IEA | -- | | GO:0042989 | sequestering of actin monomers |
IEA | -- |
TMSB4Y for ontologies About GeneDecksing
|
Drugs & Compounds
for TMSB4Y gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMSB4Y
Search CenterWatch for drugs/clinical trials and news about TMSB4Y / TYB4Y
|
Transcripts
for TMSB4Y gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMSB4Y gene: NM_004202.2 Unigene Cluster for TMSB4Y: Thymosin beta 4, Y-linked Hs.159201 [show with all ESTs]Unigene Representative Sequence: NM_0042021 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000284856(uc004ftb.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMSB4Y
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMSB4Y
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMSB4Y (NM_004202) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMSB4Y | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMSB4Y |
Additional cDNA sequence: AF000989.1 BC022482.1 BC119763.1 BC119764.1 1 DOTS entry: DT.402758 17 AceView cDNA sequences: BX116941 BI459652 NM_004202 AI365057 BF445685 AF000989 BC022482 BG716394 N50556 BX493896 N50611 BG772077 BX493885 AV747044 BE938781 AV750590 CD250150
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TMSB4Y About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c |
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| SP1: | | | - | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMSB4Y
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Expression
for TMSB4Y gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMSB4Y expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGTGAGAAG
About this image
See TMSB4Y Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMSB4Y
SOURCE GeneReport for Unigene cluster: Hs.159201
UniProtKB/Swiss-Prot: TYB4Y_HUMAN, O14604Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for TMSB4Y
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TMSB4Y | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMSB4Y | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMSB4Y | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMSB4Y |
Orthologs
for TMSB4Y gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMSB4Y gene from 3/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TMSB106 |
Uncharacterized protein |
76(a) |
1 → many |
13(14578839-14579804) |
lizard
(Anolis carolinensis) |
Reptilia |
TMSL46 |
-- |
93(a) |
1 → many |
3(120076424-120076936) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1951546 |
zgc:195154 |
77(a) |
1 → many |
9(56198178-56199762) |
ENSEMBL Gene Tree for TMSB4Y (if available)
TreeFam Gene Tree for TMSB4Y (if available) |
Paralogs
for TMSB4Y gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMSB4Y gene
- TMSB15B2 TMSB15A2 TMSB4XP42 TMSB4X2 TMSB102
5 SIMAP similar genes for TMSB4Y using alignment to 1 protein entry: TYB4Y_HUMAN:TMSB4X TMSB15A TMSB4XP4 TMSB10 TMSB15B
TMSB4Y for paralogs About GeneDecksing
|
Genomic Variants
for TMSB4Y gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr Y pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMSB4Y (15815447 - 15817904 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMSB4Y: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMSB4Y |
|
Disorders
/ Diseases
for TMSB4Y gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMSB4Y for disorders About GeneDecksing
OMIM gene information: 400017
OMIM disorders: --
1  disease for TMSB4Y: About MalaCardsx inactivation
Export disorders for TMSB4Y gene to outside databases
|
Publications
for TMSB4Y gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMSB4Y gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TMSB4Y) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional coherence of the human Y chromosome. (PubMed id 9381176)1, 2, 3 Lahn B.T. and Page D.C. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (2003)
- A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene. (PubMed id 15557202)1, 9 Torikai H....Takahashi T. (2004)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Thymosin beta 4 enhances NK cell cytotoxicity mediate d by ICAM-1. (PubMed id 19369144)1 Lee H.R....Cho D. (2009)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
- The mouse thymosin beta 4 gene: structure, promoter identification, and chromosome localization. (PubMed id 8838802)1 Li X....Yin H.L. (1996)
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External Searches for TMSB4Y gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMSB4Y gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMSB4Y gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMSB4Y gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMSB4Y | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMSB4Y gene:
Search GeneIP for patents involving TMSB4Y
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMSB4Y gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMSB4Y | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMSB4Y | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMSB4Y | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMSB4Y | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMSB4Y | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMSB4Y |
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 |  |  |  | |
| | | | Search Tocris compounds for TMSB4Y |
| |  |  |  |  | | | | |
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 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMSB4Y |
|  |  |  | | | | Search ThermoFisher Antibodies for TMSB4Y |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMSB4Y |
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