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Aliases for TMSB4Y Gene

Aliases for TMSB4Y Gene

  • Thymosin Beta 4, Y-Linked 2 3 5
  • Thymosin, Beta 4, Y Chromosome 2 3
  • TB4Y 3 4
  • Thymosin Beta-4, Y-Chromosomal 3
  • Thymosin Beta-4, Y Isoform 3

External Ids for TMSB4Y Gene

Previous GeneCards Identifiers for TMSB4Y Gene

  • GC0YP015133
  • GC0YP014824
  • GC0YP014253
  • GC0YP015815
  • GC0YP010461

Summaries for TMSB4Y Gene

Entrez Gene Summary for TMSB4Y Gene

  • This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation and encodes an actin sequestering protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMSB4Y Gene

TMSB4Y (Thymosin Beta 4, Y-Linked) is a Protein Coding gene. Among its related pathways are ERK Signaling and Regulation of actin cytoskeleton. GO annotations related to this gene include actin binding and actin monomer binding. An important paralog of this gene is TMSB4X.

UniProtKB/Swiss-Prot for TMSB4Y Gene

  • Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

Gene Wiki entry for TMSB4Y Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMSB4Y Gene

Genomics for TMSB4Y Gene

Regulatory Elements for TMSB4Y Gene

Enhancers for TMSB4Y Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0YF013435 0.9 FANTOM5 ENCODE 1.5 -267.3 -267344 1.8 CTCF HLF NR2F6 KAT2B TMSB4Y UTY PIR33577
GH0YF013704 0.6 ENCODE 0.8 +0.9 935 2.0 CTCF POLR2A ETV4 GABPB1 TEAD4 ZNF384 TEAD3 KAT8 TMSB4Y PSIP1P2
GH0YF013703 0.2 ENCODE 0.8 -0.5 -492 0.0 TMSB4Y GC0YM013490
GH0YF013663 0.4 ENCODE 0.3 -39.7 -39658 1.0 POU5F1 REST TMSB4Y GC0YM013490
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMSB4Y on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TMSB4Y gene promoter:

Genomic Location for TMSB4Y Gene

Chromosome:
Y
Start:
13,703,567 bp from pter
End:
13,706,024 bp from pter
Size:
2,458 bases
Orientation:
Plus strand

Genomic View for TMSB4Y Gene

Genes around TMSB4Y on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMSB4Y Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMSB4Y Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMSB4Y Gene

Proteins for TMSB4Y Gene

  • Protein details for TMSB4Y Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14604-TYB4Y_HUMAN
    Recommended name:
    Thymosin beta-4, Y-chromosomal
    Protein Accession:
    O14604
    Secondary Accessions:
    • Q0VDA2

    Protein attributes for TMSB4Y Gene

    Size:
    44 amino acids
    Molecular mass:
    5013 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMSB4Y Gene

Post-translational modifications for TMSB4Y Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMSB4Y Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMSB4Y Gene

Domains & Families for TMSB4Y Gene

Gene Families for TMSB4Y Gene

Protein Domains for TMSB4Y Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMSB4Y Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14604

UniProtKB/Swiss-Prot:

TYB4Y_HUMAN :
  • Belongs to the thymosin beta family.
Family:
  • Belongs to the thymosin beta family.
genes like me logo Genes that share domains with TMSB4Y: view

Function for TMSB4Y Gene

Molecular function for TMSB4Y Gene

GENATLAS Biochemistry:
thymosin-beta 4,identical to the interferon inducible gene 6-26 (4/26),potential actin sequestering protein,ubiquitous in a AZF deleted region
UniProtKB/Swiss-Prot Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

Gene Ontology (GO) - Molecular Function for TMSB4Y Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003785 actin monomer binding IEA,IBA --
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with TMSB4Y: view
genes like me logo Genes that share phenotypes with TMSB4Y: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMSB4Y Gene

Localization for TMSB4Y Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMSB4Y Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMSB4Y gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TMSB4Y Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
GO:0031941 filamentous actin IBA --
genes like me logo Genes that share ontologies with TMSB4Y: view

Pathways & Interactions for TMSB4Y Gene

genes like me logo Genes that share pathways with TMSB4Y: view

Pathways by source for TMSB4Y Gene

1 KEGG pathway for TMSB4Y Gene
1 Qiagen pathway for TMSB4Y Gene

Gene Ontology (GO) - Biological Process for TMSB4Y Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IEA --
GO:0008064 regulation of actin polymerization or depolymerization TAS 8838802
GO:0030334 regulation of cell migration IEA --
GO:0042989 sequestering of actin monomers TAS 8838802
genes like me logo Genes that share ontologies with TMSB4Y: view

No data available for SIGNOR curated interactions for TMSB4Y Gene

Transcripts for TMSB4Y Gene

mRNA/cDNA for TMSB4Y Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMSB4Y Gene

Thymosin beta 4, Y-linked:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMSB4Y Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
SP1: - -
SP2:

Relevant External Links for TMSB4Y Gene

GeneLoc Exon Structure for
TMSB4Y
ECgene alternative splicing isoforms for
TMSB4Y

Expression for TMSB4Y Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMSB4Y Gene

NURSA nuclear receptor signaling pathways regulating expression of TMSB4Y Gene:

TMSB4Y

SOURCE GeneReport for Unigene cluster for TMSB4Y Gene:

Hs.159201

mRNA Expression by UniProt/SwissProt for TMSB4Y Gene:

O14604-TYB4Y_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TMSB4Y: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TMSB4Y Gene

Orthologs for TMSB4Y Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMSB4Y Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMSB4Y 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tmsb4x 35
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TMSB4Y 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 86 (a)
OneToMany
TMSB4X 35
  • 80 (a)
OneToMany
TMSB4 35
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves TMSB4X 35
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMSB4Y 35
  • 93 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmsb4x 35
  • 77 (a)
ManyToMany
tmsb 35
  • 69 (a)
ManyToMany
si:ch211-11c15.3 35
  • 67 (a)
ManyToMany
Species where no ortholog for TMSB4Y was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMSB4Y Gene

ENSEMBL:
Gene Tree for TMSB4Y (if available)
TreeFam:
Gene Tree for TMSB4Y (if available)

Paralogs for TMSB4Y Gene

Paralogs for TMSB4Y Gene

(5) SIMAP similar genes for TMSB4Y Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMSB4Y: view

Variants for TMSB4Y Gene

Sequence variations from dbSNP and Humsavar for TMSB4Y Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs113175306 -- 13,705,628(+) TTTTT(A/T)TTTAA utr-variant-3-prime
rs13303743 -- 13,704,213(+) GAGGG(A/C)GAGAA utr-variant-5-prime
rs13303859 -- 13,704,260(+) CAGTT(A/C)CCAGT utr-variant-5-prime
rs13303862 -- 13,704,262(+) GTTCC(C/T)AGTAC utr-variant-5-prime
rs13303967 -- 13,704,214(+) AGGGC(A/G)AGAAG utr-variant-5-prime

Relevant External Links for TMSB4Y Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMSB4Y

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TMSB4Y Gene

Disorders for TMSB4Y Gene

Relevant External Links for TMSB4Y

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMSB4Y

No disorders were found for TMSB4Y Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMSB4Y Gene

Publications for TMSB4Y Gene

  1. Functional coherence of the human Y chromosome. (PMID: 9381176) Lahn B.T. … Page D.C. (Science 1997) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene. (PMID: 15557202) Torikai H. … Takahashi T. (J. Immunol. 2004) 3 22 64
  4. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 3 4 64
  5. TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer. (PMID: 26702755) Wong H.Y. … Park B.H. (Oncotarget 2015) 3 64

Products for TMSB4Y Gene

Sources for TMSB4Y Gene

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