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TMSB4X Gene

protein-coding   GIFtS: 59
GCID: GC0XP012993

Thymosin Beta 4, X-Linked

(Previous names: thymosin, beta 4, X chromosome)
(Previous symbol: TMSB4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thymosin Beta 4, X-Linked1 2     FX2
TMSB41 2 3 5     Prothymosin Beta-42
TB4X2 3 5     Thymosin Beta-42
Thymosin, Beta 4, X Chromosome1 2     Fx3
T Beta-42 3     THYB43
PTMB42 5     

External Ids:    HGNC: 118811   Entrez Gene: 71142   Ensembl: ENSG000002055427   OMIM: 3001595   UniProtKB: P623283   

Export aliases for TMSB4X gene to outside databases

Previous GC identifers: GC04M091917 GC04M092061 GC0XP012354 GC0XP012752 GC0XP012903 GC0XP010756


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMSB4X Gene:
This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The
protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation
and has a homolog on chromosome Y. (provided by RefSeq, Jul 2008)

GeneCards Summary for TMSB4X Gene:
TMSB4X (thymosin beta 4, X-linked) is a protein-coding gene. Diseases associated with TMSB4X include vernal keratoconjunctivitis, and thymoma. GO annotations related to this gene include actin binding. An important paralog of this gene is TMSB15B.

UniProtKB/Swiss-Prot: TYB4_HUMAN, P62328
Function: Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters
actin monomers (G actin) and therefore inhibits actin polymerization
Function: Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity)

Gene Wiki entry for TMSB4X (Thymosin beta-4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMSB4X gene promoter:
         PPAR-gamma1   AP-1   ATF-2   c-Jun   PPAR-gamma2   NF-kappaB1   NF-kappaB   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TMSB4X

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMSB4X


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.3-q22   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.2

TMSB4X Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMSB4X gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP012993:  view genomic region     (about GC identifiers)

Start:
12,993,226 bp from pter      End:
12,995,346 bp from pter
Size:
2,121 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TYB4_HUMAN, P62328 (See protein sequence)
Recommended Name: Thymosin beta-4  
Size: 44 amino acids; 5053 Da
Subunit: Interacts with SERPINB1 (By similarity). Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X
2 PDB 3D structures from and Proteopedia for TMSB4X:
1UY5 (3D)        3TU5 (3D)    
Secondary accessions: P01253 P01254 Q546P5 Q63576 Q9UE55

Explore the universe of human proteins at neXtProt for TMSB4X: NX_P62328

Explore proteomics data for TMSB4X at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys4, Lys12, Lys26, Lys32, Lys39
  • Modification sites at PhosphoSitePlus

  • See TMSB4X Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066932.1  
    ENSEMBL proteins: 
     ENSP00000414376   ENSP00000370010   ENSP00000370009   ENSP00000370007  
    Reactome Protein details: P62328

    TMSB4X Human Recombinant Protein Products:

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    Novus Biologicals TMSB4X Protein
    Novus Biologicals TMSB4X Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TMSB4X
    Browse Proteins at Cloud-Clone Corp.

    TMSB4X Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TMSB4X
    R&D Systems Antibodies for TMSB4X (Thymosin beta 4)
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    Abcam antibodies for TMSB4X
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    LSBio Antibodies in human, mouse, rat for TMSB4X

    TMSB4X Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001152 Thymosin_b4
     IPR016323 Thymosin_b4_metazoa

    Graphical View of Domain Structure for InterPro Entry P62328

    ProtoNet protein and cluster: P62328

    UniProtKB/Swiss-Prot: TYB4_HUMAN, P62328
    Similarity: Belongs to the thymosin beta family


    TMSB4X for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYB4_HUMAN, P62328
    Function: Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters
    actin monomers (G actin) and therefore inhibits actin polymerization
    Function: Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity)
    Induction: By alpha interferons. Decreased levels in THP-1 cells after treatment with recombinant
    interferon-lambda

         Genatlas biochemistry entry for TMSB4X:
    thymosin beta 4,identical to the interferon inducible gene 6-26 (4/6-26)-like 7,potential actin sequestering
    protein,escaping inactivation,ubiquitous

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI17967441
    GO:0044822poly(A) RNA binding IDA--
         
    TMSB4X for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tmsb4x):
     cardiovascular system  homeostasis/metabolism  mortality/aging  muscle  nervous system 
     normal  vision/eye 

    TMSB4X for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TMSB4X: Tmsb4xtm1Prri Tmsb4xtm1.1Chen

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMSB4X
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMSB4X

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMSB4X
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMSB4X

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMSB4X:
    hsa-mir-1 (MIRT001845)

    Block miRNA regulation of human, mouse, rat TMSB4X using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMSB4X (see all 31):
    hsa-miR-579 hsa-miR-217 hsa-miR-148b* hsa-miR-3673 hsa-miR-448 hsa-miR-199b-3p hsa-miR-520d-5p hsa-miR-148b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TMSB4X
    Predesigned siRNA for gene silencing in human, mouse, rat TMSB4X

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for TMSB4X (see all 6)
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    GenScript: all cDNA clones in your preferred vector: TMSB4X (NM_021109)
    Sino Biological Human cDNA Clone for TMSB4X
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMSB4X
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMSB4X

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TMSB4X 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMSB4X


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TYB4_HUMAN, P62328: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    extracellular4
    cytosol3
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005737cytoplasm ----
    GO:0005856cytoskeleton IEA--
    GO:0031093platelet alpha granule lumen TAS--

    TMSB4X for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TMSB4X About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    3Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    4ERK Signaling
    ILK Signaling0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TMSB4X
        ILK Signaling

    1 BioSystems Pathway for TMSB4X
        Regulation of Actin Cytoskeleton


    1 Reactome Pathway for TMSB4X
        Platelet degranulation


    1 Kegg Pathway  (Kegg details for TMSB4X):
        Regulation of actin cytoskeleton


    TMSB4X for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMSB4X
    Interactions:

        GeneGlobe Interaction Network for TMSB4X

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for TMSB4X (P623281, 2, 3 ENSP000003700074) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271597 I2D: score=2 
    SMN2Q166372, 3MINT-8271597 I2D: score=2 
    MLH1P406921, 3, ENSP000002317904EBI-712598,EBI-744248 I2D: score=1 STRING: ENSP00000231790
    ANXA7P200732, 3MINT-8248805 I2D: score=2 
    CDKN1AP389362, 3MINT-8252318 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0007010cytoskeleton organization ----
    GO:0007596blood coagulation TAS--
    GO:0030036actin cytoskeleton organization IEA--
    GO:0030168platelet activation TAS--

    TMSB4X for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMSB4X (TYB4)

    Selected Novoseek inferred chemical compound relationships for TMSB4X gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tetrapeptide 66.6 3 12916639 (1), 17191900 (1), 2253778 (1)
    matrigel 37.6 3 8719875 (2), 16423999 (1)
    phalloidin 37 2 8055911 (2)
    perchloric acid 23.8 1 2209614 (1)
    lysine 18 1 18327913 (1)
    cytarabine 14.4 1 12962156 (1)
    atp 11.3 9 14623892 (2), 8506348 (1), 8576116 (1), 8055911 (1) (see all 7)
    methionine 6.64 1 9563520 (1)
    adp 4.43 4 8506348 (1), 10940259 (1), 8055911 (1), 7787248 (1)
    fibrinogen 1.27 4 17892513 (2), 8514613 (1)



    TMSB4X for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMSB4X gene: 
    NM_021109.3  

    Unigene Cluster for TMSB4X:

    Thymosin beta 4, X-linked
    Hs.437277  [show with all ESTs]
    Unigene Representative Sequence: BF680512
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451311(uc004cvf.3) ENST00000380636 ENST00000380635 ENST00000380633

    miRNA
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    Block miRNA regulation of human, mouse, rat TMSB4X using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMSB4X (see all 31):
    hsa-miR-579 hsa-miR-217 hsa-miR-148b* hsa-miR-3673 hsa-miR-448 hsa-miR-199b-3p hsa-miR-520d-5p hsa-miR-148b
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      QuantiTect SYBR Green Assays in human, mouse, rat TMSB4X
      QuantiFast Probe-based Assays in human, mouse, rat TMSB4X

    Additional mRNA sequence: 

    AK055976.1 AK057827.1 AK311747.1 BC001631.1 BC016732.1 BC022857.1 BC061586.1 BC062436.1 
    BC064954.1 BC070248.1 BC070249.1 BC083509.1 BC092437.1 BC101790.1 BC101792.1 BC104464.1 
    BC104465.1 BC104666.1 BC107789.1 BC128102.1 BC128103.1 BC139925.1 BC141975.1 BC141976.1 
    BC151215.1 BT007090.1 M17733.1 X02493.1 

    Selected DOTS entries (see all 102):

    DT.95377392  DT.100741234  DT.100741255  DT.100741219  DT.92471824  DT.92471804  DT.100741263  DT.121313106 
    DT.95377459  DT.100741220  DT.100060434  DT.85101298  DT.100867513  DT.100741218  DT.91910729  DT.95335616 
    DT.100741252  DT.91981905  DT.100741239  DT.91820572  DT.100741227  DT.100741257  DT.121313016  DT.95377808 

    Selected AceView cDNA sequences (see all 4052):

    AA328515 CB107592 F24285 BM560244 BM772901 BP342073 N74325 BP341939 
    AI354514 BM840616 BM817688 BM749675 BQ434237 AW157638 BM752916 AI734959 
    BM757454 AI186065 BC001631 AI126823 BM799425 W94023 AI626111 W94128 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMSB4X expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTGAAGG
    TMSB4X Expression
    About this image


    TMSB4X expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
    TMSB4X Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMSB4X Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437277

    UniProtKB/Swiss-Prot: TYB4_HUMAN, P62328
    Tissue specificity: Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in
    myeloma cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMSB4X

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TMSB4X gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmsb4x5 thymosin, beta 4, X chromosome   --   X (78.28 cM) 167207093 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125592 Transcribed sequence with moderate similarity to protein more 73.83(n)    CF999620.1 
    soybean
    (Glycine max)
    eudicotyledons 445109412   -- 87.29(n)  


    ENSEMBL Gene Tree for TMSB4X (if available)
    TreeFam Gene Tree for TMSB4X (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMSB4X gene
    TMSB15B2  TMSB15A2  TMSB4Y2  TMSB102  
    5 SIMAP similar genes for TMSB4X using alignment to 7 protein entries:     TYB4_HUMAN (see all proteins):
    TMSB15A    TMSB4XP4    TMSB4Y    TMSB10    TMSB15B

    TMSB4X for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TMSB4X
    PGOHUM00000262015


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMSB4X (see all 83)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868945751,2
    --12991258(+) TTTCCA/TTGTAT 1 -- us2k10--------
    rs1903964041,2
    --12991355(+) GCAGTC/TGTCTC 1 -- us2k10--------
    rs1420785071,2
    --12991496(+) TTGCTG/TCAGTG 1 -- us2k10--------
    rs1833404771,2
    --12991868(+) GACCAA/GACGGT 1 -- us2k10--------
    rs1875844561,2
    --12991870(+) CCAGAC/TGGTCA 1 -- us2k10--------
    rs1897356891,2
    C--12991888(+) CTGCTA/CACCCC 1 -- us2k10--------
    rs9366681,2
    C,F,O,A,H--12992007(-) GTCTCT/GCTGGG 1 -- us2k123Minor allele frequency- G:0.48NA EA NS 2652
    rs9366671,2
    C,F--12992022(-) ATGGCA/GCAGGC 1 -- us2k1 tfbs34Minor allele frequency- G:0.02EA NA WA 48
    rs1827218401,2
    --12992276(+) CTACCC/GGAATC 1 -- us2k10--------
    rs96980931,2
    C,F,H--12992690(+) GTCCCA/GCCCAA 1 -- us2k117Minor allele frequency- G:0.04NS EA NA WA 1652

    HapMap Linkage Disequilibrium report for TMSB4X (12993226 - 12995346 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMSB4X:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1002384CNV Gain20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMSB4X
    DNA2.0 Custom Variant and Variant Library Synthesis for TMSB4X

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300159    OMIM disorders: --

    Selected diseases for TMSB4X (see all 38):    
    About MalaCards
    vernal keratoconjunctivitis    thymoma    keratoconjunctivitis    fibrosarcoma
    keloids    interstitial lung disease    ischemic heart disease    gigantism
    epidermolysis bullosa    lynch syndrome    proliferative diabetic retinopathy    scleroderma
    diabetic retinopathy    gingivitis    cystic fibrosis    myocardial infarction
    ischemia    rheumatoid arthritis    hypoxia    arthritis


    TMSB4X for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TMSB4X gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    b-all 36.5 1 9477130 (1)
    colorectal carcinoma 28.8 1 17072345 (1)
    fibrosarcoma 25.8 1 19405119 (1)
    thymoma 22.3 1 2333664 (1)
    scar 14.6 3 15698487 (1)
    tumors 14.4 36 16949646 (4), 20353910 (3), 17495241 (3), 2043590 (2) (see all 21)
    colon carcinoma 11.6 1 16364925 (1)
    metastasis 11 9 12970751 (2), 16956606 (1), 17923415 (1), 17916567 (1) (see all 8)
    inflammation 3.07 4 16630613 (1), 17200658 (1), 17083265 (1), 12358412 (1)
    colon cancer 1.12 3 16501890 (1), 17072345 (1), 16364925 (1)

    Genetic Association Database (GAD): TMSB4X

    Export disorders for TMSB4X gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMSB4X gene, integrated from 10 sources (see all 213):
    (articles sorted by number of sources associating them with TMSB4X)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. (PubMed id 1999398)1, 2, 9 Safer D.... Nachmias V.T. (J. Biol. Chem. 1991)
    2. Structural requirements for thymosin beta4 in its contact with actin. An NMR-analysis of thymosin beta4 mutants in solution and correlation with their biological activity. (PubMed id 10848969)1, 2, 9 Simenel C.... Delepierre M. (Eur. J. Biochem. 2000)
    3. Molecular cloning and structural characterization of the functional human thymosin beta4 gene. (PubMed id 16010977)1, 2 Yang S.P.... Su Y. (Mol. Cell. Biochem. 2005)
    4. Functional coherence of the human Y chromosome. (PubMed id 9381176)1, 3 Lahn B.T. and Page D.C. (Science 1997)
    5. Thymosin-beta 4 gene. Preliminary characterization and expression in tissues, thymic cells, and lymphocytes. (PubMed id 2677145)1, 3 GA^mez-MA!rquez J....Freire M. (J. Immunol. 1989)
    6. Differential expression of the human thymosin-beta 4 gene in lymphocytes, macrophages, and granulocytes. (PubMed id 3500230)1, 2 Gondo H....Saunders G.F. (J. Immunol. 1987)
    7. Transcriptional and posttranscriptional regulation of interferon- induced gene expression in human cells. (PubMed id 6548414)1, 2 Friedman R.L.... Stark G.R. (Cell 1984)
    8. Thymosin beta 4 binds actin in an extended conformation and contacts both the barbed and pointed ends. (PubMed id 9153421)1, 9 Safer D....Elzinga M. (Biochemistry 1997)
    9. Occurrence of thymosin beta4 in human breast cancer cells and in other cell types of the tumor microenvironment. (PubMed id 16949646)1, 9 Larsson L.I. and Holck S. (Hum. Pathol. 2007)
    10. Reduction of thymosin beta4 and actin in HL60 cells during apoptosis is preceded by a decrease of their mRNAs. (PubMed id 12962156)1, 9 MA1ller C.S....Hannappel E. (Mol. Cell. Biochem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7114 HGNC: 11881 AceView: TMSB4X Ensembl:ENSG00000205542 euGenes: HUgn7114
    ECgene: TMSB4X Kegg: 7114 H-InvDB: TMSB4X

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMSB4X Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TMSB4X Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TMSB4X gene:
    Search GeneIP for patents involving TMSB4X

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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