Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMSB4X Gene

protein-coding   GIFtS: 58
GCID: GC0XP012993

Thymosin Beta 4, X-Linked

(Previous names: thymosin, beta 4, X chromosome)
(Previous symbol: TMSB4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thymosin Beta 4, X-Linked1 2     FX2
TMSB41 2 3 5     Prothymosin Beta-42
TB4X2 3 5     Thymosin Beta-42
Thymosin, Beta 4, X Chromosome1 2     Fx3
T Beta-42 3     THYB43
PTMB42 5     

External Ids:    HGNC: 118811   Entrez Gene: 71142   Ensembl: ENSG000002055427   OMIM: 3001595   UniProtKB: P623283   

Export aliases for TMSB4X gene to outside databases

Previous GC identifers: GC04M091917 GC04M092061 GC0XP012354 GC0XP012752 GC0XP012903 GC0XP010756


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMSB4X Gene:
This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The
protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation
and has a homolog on chromosome Y. (provided by RefSeq, Jul 2008)

GeneCards Summary for TMSB4X Gene: 
TMSB4X (thymosin beta 4, X-linked) is a protein-coding gene. Diseases associated with TMSB4X include rheumatoid arthritis, association with, and vernal keratoconjunctivitis, and among its related super-pathways are Regulation of actin cytoskeleton and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include protein binding and actin binding. An important paralog of this gene is TMSB15B.

UniProtKB/Swiss-Prot: TYB4_HUMAN, P62328
Function: Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters
actin monomers (G actin) and therefore inhibits actin polymerization
Function: Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity)

Gene Wiki entry for TMSB4X (Thymosin beta-4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMSB4X gene promoter:
         PPAR-gamma1   AP-1   ATF-2   c-Jun   PPAR-gamma2   NF-kappaB1   NF-kappaB   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TMSB4X

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMSB4X


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.3-q22   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.2

TMSB4X Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMSB4X gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP012993:  view genomic region     (about GC identifiers)

Start:
12,993,226 bp from pter      End:
12,995,346 bp from pter
Size:
2,121 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TYB4_HUMAN, P62328 (See protein sequence)
Recommended Name: Thymosin beta-4  
Size: 44 amino acids; 5053 Da
Subunit: Interacts with SERPINB1 (By similarity). Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X
Subcellular location: Cytoplasm, cytoskeleton
2 PDB 3D structures from and Proteopedia for TMSB4X:
1UY5 (3D)        3TU5 (3D)    
Secondary accessions: P01253 P01254 Q546P5 Q63576 Q9UE55

Explore the universe of human proteins at neXtProt for TMSB4X: NX_P62328

Explore proteomics data for TMSB4X at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62328

  • TMSB4X Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMSB4X Protein Expression
    REFSEQ proteins: NP_066932.1  
    ENSEMBL proteins: 
     ENSP00000414376   ENSP00000370010   ENSP00000370009   ENSP00000370007  
    Reactome Protein details: P62328
    Human Recombinant Protein Products for TMSB4X: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TMSB4X
    OriGene Protein Over-expression Lysate for TMSB4X
    OriGene MassSpec for TMSB4X 
    OriGene Custom Protein Services for TMSB4X
    GenScript Custom Purified and Recombinant Proteins Services for TMSB4X
    Novus Biologicals TMSB4X Protein
    Novus Biologicals TMSB4X Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TMSB4X
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005737cytoplasm ----
    GO:0005856cytoskeleton IEA--
    GO:0031093platelet alpha granule lumen TAS--

    TMSB4X for ontologies           About GeneDecksing



    TMSB4X Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TMSB4X
    R&D Systems Antibodies for TMSB4X (Thymosin beta 4)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TMSB4X
    GenScript Custom Superior Antibodies Services for TMSB4X
    Novus Biologicals TMSB4X Antibodies
    Abcam antibodies for TMSB4X
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for TMSB4X
    LSBio Antibodies in human, mouse, rat for TMSB4X 

    Assay Products for TMSB4X: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TMSB4X
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMSB4X
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001152 Thymosin_b4
     IPR016323 Thymosin_b4_chordata

    Graphical View of Domain Structure for InterPro Entry P62328

    ProtoNet protein and cluster: P62328

    UniProtKB/Swiss-Prot: TYB4_HUMAN, P62328
    Similarity: Belongs to the thymosin beta family


    TMSB4X for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYB4_HUMAN, P62328
    Function: Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters
    actin monomers (G actin) and therefore inhibits actin polymerization
    Function: Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity)
    Induction: By alpha interferons. Decreased levels in THP-1 cells after treatment with recombinant
    interferon-lambda

         Genatlas biochemistry entry for TMSB4X:
    thymosin beta 4,identical to the interferon inducible gene 6-26 (4/6-26)-like 7,potential actin sequestering
    protein,escaping inactivation,ubiquitous

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI17967441
         
    TMSB4X for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tmsb4x):
     cardiovascular system  homeostasis/metabolism  mortality/aging  muscle  nervous system 
     normal  vision/eye 

    TMSB4X for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TMSB4X: Tmsb4xtm1Prri Tmsb4xtm1.1Chen

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMSB4X 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMSB4X

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMSB4X 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMSB4X 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMSB4X
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate TMSB4X (see all 31):
    hsa-miR-579 hsa-miR-217 hsa-miR-148b* hsa-miR-3673 hsa-miR-448 hsa-miR-199b-3p hsa-miR-520d-5p hsa-miR-148b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TMSB4X
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMSB4X

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMSB4X
    Sirion Biotech Customized adenovirus for overexpression of TMSB4X

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TMSB4X (see all 7)
    OriGene ORF clones in mouse, rat for TMSB4X
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMSB4X (NM_021109)
    Sino Biological Human cDNA Clone for TMSB4X
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMSB4X
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMSB4X
    Sirion Biotech Customized lentivirus for stable overexpression of TMSB4X 
                         Customized lentivirus expression plasmids for stable overexpression of TMSB4X 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TMSB4X
    Search LifeMap BioReagents cell lines for TMSB4X
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMSB4X


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TMSB4X About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    2Platelet degranulation
    Platelet degranulation 0.94
    Response to elevated platelet cytosolic Ca2+0.94
    3Platelet activation, signaling and aggregation
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    4Rho Family GTPases
    ILK Signaling0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TMSB4X
        ILK Signaling

    1 BioSystems Pathway for TMSB4X
        Regulation of Actin Cytoskeleton


    4        Reactome Pathways for TMSB4X
        Hemostasis
    Platelet degranulation
    Platelet activation, signaling and aggregation
    Response to elevated platelet cytosolic Ca2+


    1         Kegg Pathway  (Kegg details for TMSB4X):
        Regulation of actin cytoskeleton


    TMSB4X for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TMSB4X

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/29 Interacting proteins for TMSB4X (P623281, 2, 3 ENSP000003700074) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271597 I2D: score=2 
    SMN2Q166372, 3MINT-8271597 I2D: score=2 
    MLH1P406921, 3, ENSP000002317904EBI-712598,EBI-744248 I2D: score=1 STRING: ENSP00000231790
    ANXA7P200732, 3MINT-8248805 I2D: score=2 
    CDKN1AP389362, 3MINT-8252318 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001649osteoblast differentiation ----
    GO:0002576platelet degranulation TAS--
    GO:0007010cytoskeleton organization ----
    GO:0007596blood coagulation TAS--
    GO:0030036actin cytoskeleton organization IEA--

    TMSB4X for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TMSB4X for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMSB4X (TYB4)

    10/17 Novoseek inferred chemical compound relationships for TMSB4X gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tetrapeptide 66.6 3 12916639 (1), 17191900 (1), 2253778 (1)
    matrigel 37.6 3 8719875 (2), 16423999 (1)
    phalloidin 37 2 8055911 (2)
    perchloric acid 23.8 1 2209614 (1)
    lysine 18 1 18327913 (1)
    cytarabine 14.4 1 12962156 (1)
    atp 11.3 9 14623892 (2), 8506348 (1), 8576116 (1), 8055911 (1) (see all 7)
    methionine 6.64 1 9563520 (1)
    adp 4.43 4 8506348 (1), 10940259 (1), 8055911 (1), 7787248 (1)
    fibrinogen 1.27 4 17892513 (2), 8514613 (1)

    Search CenterWatch for drugs/clinical trials and news about TMSB4X / TYB4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMSB4X gene: 
    NM_021109.3  

    Unigene Clusters for TMSB4X:

    Thymosin beta 4, X-linked
    Hs.437277  [show with all ESTs], Hs.703237  [show with all ESTs]
    Unigene Representative Sequences: BF680512, BU595201
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451311(uc004cvf.3) ENST00000380636 ENST00000380635 ENST00000380633

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMSB4X
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate TMSB4X (see all 31):
    hsa-miR-579 hsa-miR-217 hsa-miR-148b* hsa-miR-3673 hsa-miR-448 hsa-miR-199b-3p hsa-miR-520d-5p hsa-miR-148b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TMSB4X
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMSB4X
    Clone
    Products:
         
    OriGene clones in human, mouse for TMSB4X (see all 7)
    OriGene ORF clones in mouse, rat for TMSB4X
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMSB4X (NM_021109)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMSB4X
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMSB4X
    Sirion Biotech Customized lentivirus for stable overexpression of TMSB4X 
                         Customized lentivirus expression plasmids for stable overexpression of TMSB4X 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMSB4X
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat TMSB4X
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMSB4X
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMSB4X

    Additional mRNA sequence: M11948.1 

    24/107 DOTS entries (see all 107):

    DT.95377392  DT.100741234  DT.100741263  DT.92471804  DT.100741219  DT.100741255  DT.92471824  DT.121313106 
    DT.95377459  DT.100741220  DT.100060434  DT.85101298  DT.100867513  DT.100741218  DT.91910729  DT.95335616 
    DT.100741252  DT.100741239  DT.91981905  DT.91820572  DT.100741257  DT.100741227  DT.121313016  DT.121313144 

    24/4052 AceView cDNA sequences (see all 4052):

    BQ548698 AV717580 CB137177 AI905297 BM835863 BM843115 BM833914 BQ708138 
    BM757301 AA301222 CB108091 AW575631 BM757426 H38729 AI003788 BM840956 
    AI888328 BM761306 AW162290 AA328515 CB107592 F24285 BM560244 BM772901 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMSB4X expression in normal human tissues (normalized intensities)      TMSB4X embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTGAAGG
    TMSB4X Expression
    About this image


    TMSB4X expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle

    See TMSB4X Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMSB4X

    SOURCE GeneReport for Unigene clusters: Hs.437277 Hs.703237

    UniProtKB/Swiss-Prot: TYB4_HUMAN, P62328
    Tissue specificity: Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in
    myeloma cells

        SABiosciences Custom PCR Arrays for TMSB4X
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMSB4X
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat TMSB4X
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMSB4X
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMSB4X
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMSB4X

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TMSB4X gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmsb4x5 thymosin, beta 4, X chromosome   --   X (78.28 cM) 167207093 
    chicken
    (Gallus gallus)
    Aves TMSB4X6
    thymosin, beta 4
    100(a)
    1 ↔ 1
    1(122807092-122808710)
    lizard
    (Anolis carolinensis)
    Reptilia TMSB4Y6
    Uncharacterized protein
    100(a)
    possible ortholog
    3(120076414-120077268)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125592 Transcribed sequence with moderate similarity to protein more 73.83(n)    CF999620.1 
    soybean
    (Glycine max)
    eudicotyledons 445109412   -- 87.29(n)  


    ENSEMBL Gene Tree for TMSB4X (if available)
    TreeFam Gene Tree for TMSB4X (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMSB4X gene
    TMSB15B2  TMSB15A2  TMSB4Y2  TMSB102  
    5 SIMAP similar genes for TMSB4X using alignment to 7 protein entries:     TYB4_HUMAN (see all proteins):
    TMSB15A    TMSB4XP4    TMSB4Y    TMSB10    TMSB15B

    TMSB4X for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TMSB4X
    PGOHUM00000262015


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/83 SNPs in TMSB4X are shown (see all 83)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868945751,2
    --12991258(+) TTTCCA/TTGTAT 1 -- us2k10--------
    rs1903964041,2
    --12991355(+) GCAGTC/TGTCTC 1 -- us2k10--------
    rs1420785071,2
    --12991496(+) TTGCTG/TCAGTG 1 -- us2k10--------
    rs1833404771,2
    --12991868(+) GACCAA/GACGGT 1 -- us2k10--------
    rs1875844561,2
    --12991870(+) CCAGAC/TGGTCA 1 -- us2k10--------
    rs1897356891,2
    C--12991888(+) CTGCTA/CACCCC 1 -- us2k10--------
    rs9366681,2
    C,F,O,A,H--12992007(-) GTCTCT/GCTGGG 1 -- us2k123Minor allele frequency- G:0.48NA EA NS 2652
    rs9366671,2
    C,F--12992022(-) ATGGCA/GCAGGC 1 -- us2k1 tfbs34Minor allele frequency- G:0.02EA NA WA 48
    rs1827218401,2
    --12992276(+) CTACCC/GGAATC 1 -- us2k10--------
    rs96980931,2
    C,F,H--12992690(+) GTCCCA/GCCCAA 1 -- us2k117Minor allele frequency- G:0.04NS EA NA WA 1652

    HapMap Linkage Disequilibrium report for TMSB4X (12993226 - 12995346 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMSB4X:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1002384CNV Gain20482838

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMSB4X
    DNA2.0 Custom Variant and Variant Library Synthesis for TMSB4X

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300159    OMIM disorders: --

    20/38 diseases for TMSB4X (see all 38):    About MalaCards
    rheumatoid arthritis, association with    vernal keratoconjunctivitis    thymoma    keratoconjunctivitis
    fibrosarcoma    interstitial lung disease    keloids    ischemic heart disease
    gigantism    epidermolysis bullosa    hiv type 1    scleroderma
    diabetic retinopathy    gingivitis    cystic fibrosis    colon cancer
    rheumatoid arthritis    hypoxia    arthritis    myocardial infarction


    TMSB4X for disorders           About GeneDecksing

    10/20 Novoseek inferred disease relationships for TMSB4X gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    b-all 36.5 1 9477130 (1)
    colorectal carcinoma 28.8 1 17072345 (1)
    fibrosarcoma 25.8 1 19405119 (1)
    thymoma 22.3 1 2333664 (1)
    scar 14.6 3 15698487 (1)
    tumors 14.4 36 16949646 (4), 20353910 (3), 17495241 (3), 2043590 (2) (see all 21)
    colon carcinoma 11.6 1 16364925 (1)
    metastasis 11 9 12970751 (2), 16956606 (1), 17923415 (1), 17916567 (1) (see all 8)
    inflammation 3.07 4 16630613 (1), 17200658 (1), 17083265 (1), 12358412 (1)
    colon cancer 1.12 3 16501890 (1), 17072345 (1), 16364925 (1)

    Genetic Association Database (GAD): TMSB4X

    Export disorders for TMSB4X gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMSB4X gene, integrated from 9 sources (see all 205):
    (articles sorted by number of sources associating them with TMSB4X)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. (PubMed id 1999398)1, 2, 9 Safer D.... Nachmias V.T. (1991)
    2. Structural requirements for thymosin beta4 in its contact with actin. An NMR-analysis of thymosin beta4 mutants in solution and correlation with their biological activity. (PubMed id 10848969)1, 2, 9 Simenel C.... Delepierre M. (2000)
    3. Molecular cloning and structural characterization of the functional human thymosin beta4 gene. (PubMed id 16010977)1, 2 Yang S.P.... Su Y. (2005)
    4. Functional coherence of the human Y chromosome. (PubMed id 9381176)1, 3 Lahn B.T. and Page D.C. (1997)
    5. Thymosin-beta 4 gene. Preliminary characterization and expression in tissues, thymic cells, and lymphocytes. (PubMed id 2677145)1, 3 Gomez-Marquez J....Freire M. (1989)
    6. Differential expression of the human thymosin-beta 4 gene in lymphocytes, macrophages, and granulocytes. (PubMed id 3500230)1, 2 Gondo H....Saunders G.F. (1987)
    7. Transcriptional and posttranscriptional regulation of interferon- induced gene expression in human cells. (PubMed id 6548414)1, 2 Friedman R.L.... Stark G.R. (1984)
    8. Thymosin beta 4 binds actin in an extended conformation and contacts both the barbed and pointed ends. (PubMed id 9153421)1, 9 Safer D....Elzinga M. (1997)
    9. Occurrence of thymosin beta4 in human breast cancer cells and in other cell types of the tumor microenvironment. (PubMed id 16949646)1, 9 Larsson L.I. and Holck S. (2007)
    10. Reduction of thymosin beta4 and actin in HL60 cells during apoptosis is preceded by a decrease of their mRNAs. (PubMed id 12962156)1, 9 Muller C.S....Hannappel E. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7114 HGNC: 11881 AceView: TMSB4X Ensembl:ENSG00000205542 euGenes: HUgn7114
    ECgene: TMSB4X Kegg: 7114 H-InvDB: TMSB4X

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMSB4X Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TMSB4X Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMSB4X gene:
    Search GeneIP for patents involving TMSB4X

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TMSB4X
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for TMSB4X (Thymosin beta 4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TMSB4X  
     OriGene qPCR primer pairs and template standards for TMSB4X   OriGene Protein Over-expression Lysate for TMSB4X  
     OriGene MassSpec something-or-other for TMSB4X   OriGene clones in human, mouse for TMSB4X  
     Browse OriGene qSTAR qPCR primer pairs   OriGene Purified Protein for TMSB4X  
     OriGene ORF clones in mouse, rat for TMSB4X   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TMSB4X   OriGene Custom Protein Services for TMSB4X  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMSB4X
     QIAGEN SeqTarget long-range PCR primers for resequencing TMSB4X
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMSB4X
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMSB4X
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMSB4X
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMSB4X
     GenScript Custom Purified and Recombinant Proteins Services for TMSB4X GenScript cDNA clones with any tag delivered in your preferred vector for TMSB4X
     GenScript Custom Assay Services for TMSB4X GenScript Custom Superior Antibodies Services for TMSB4X
     GenScript Custom overexpressing Cell Line Services for TMSB4X CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TMSB4X promoter
     Search Chromatin IP Primers for TMSB4X
     RT2 qPCR Primer Assay in human, mouse / rat TMSB4X
     GNC Network for TMSB4X
     SABiosciences PCR Arrays including human, mouse, rat TMSB4X
     Search Tocris compounds for TMSB4X (TYB4)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for TMSB4X
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TMSB4X antibodies
     TMSB4X proteins
     TMSB4X lysates
     Antibodies for TMSB4X
     See all of Abcam's Antibodies, Kits and Proteins for TMSB4X
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TMSB4X




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for TMSB4X
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMSB4X
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TMSB4X
     Browse SwitchGear Promoter luciferase reporter plasmids for TMSB4X
     Search ThermoFisher Antibodies for TMSB4X
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMSB4X
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TMSB4X
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMSB4X
    Customized:
     lentivirus for stable overexpression of TMSB4X
     lentivirus expression plasmids for stable overexpression of TMSB4X
     adenovirus for overexpression of TMSB4X
     LSBio Antibodies in human, mouse, rat for TMSB4X
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TMSB4X gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4